Classifications

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Definitions

• the present invention relates to Japanese patent applications: Japanese Patent Application No. 2020-146939 (filed on September 1, 2020), Japanese Patent Application No. 2021-283 (filed on January 12, 2021), and Japanese Patent Application No. 2021-121685 (2021). It is based on the priority claim of (filed on July 26, 2014), and all the contents of the application shall be incorporated and described in this document by citation.
• the present disclosure relates to a composition containing adenosine.
• the present disclosure relates to a method of suppressing the precipitation of adenosine in an aqueous solvent.
• Adenosine is known to have a blood circulation promoting effect when applied to the skin. It is also known that adenosine also has an effect of producing a hair growth promoting factor in dermal papilla cells. Therefore, adenosine is applied to external skin preparations such as hair growth agents (see, for example, Patent Document 1).
• the external composition described in Patent Document 1 contains 1.0 to 2.0% by mass of adenosine and 10.0 to 20.0% by mass of a moisturizer as a whole of the composition, and the moisturizing agent is contained.
• the content of the sugar-based moisturizer in the agent is 20.0 to 100% by mass of the whole moisturizer, and the lower alcohol is contained in 35.0 to 65.0% by mass of the whole composition.
• adenosine-containing composition as described in Patent Document 1 In order for the adenosine-containing composition as described in Patent Document 1 to act effectively on the skin, adenosine needs to be dissolved in a solvent. However, adenosine has low solubility in water. Therefore, in the composition described in Patent Document 1, in order to dissolve adenosine in an aqueous solvent, ethanol (generally referred to as "alcohol”) in an amount of 30% by mass or more based on the mass of the composition is used. However, when ethanol is applied to the skin, some people may develop abnormalities on the skin or cause an allergic reaction to ethanol. Adenosine-containing products with a low ethanol content are also desired for such people who cannot apply ethanol to their skin. In recent years, there has been an increasing demand for alcohol-free external skin preparations.
• adenosine may be dissolved in the aqueous solvent.
• the ethanol concentration in the composition described in Patent Document 1 is lowered, even if the adenosine can be once dissolved in a room temperature environment (for example, 25 ° C. or higher), the adenosine solution is temporarily stored in a low temperature environment (for example, 0 ° C. or higher). ), Adenosine cannot maintain its dissolved state and precipitates.
• an adenosine-containing composition capable of suppressing the precipitation of adenosine at a low temperature or ensuring a dissolved state of adenosine at room temperature is desired even if the ethanol content is low. Further, a method for suppressing the precipitation of dissolved adenosine and / or a method for facilitating the redissolution of the precipitated adenosine is desired even in an aqueous solvent having a low ethanol content.
• Adenosine (B) at least one selected from the group consisting of glycyrrhizic acid and its salt, salicylic acid and its salt, and a vegetable extract, and (C) water.
• Adenosine-containing compositions comprising, are provided. Ethanol is less than 20% by weight based on the mass of the adenosine-containing composition.
• a method for suppressing the precipitation of adenosine which comprises a step of dissolving adenosine and the first component in an aqueous solvent containing less than 20% by mass of ethanol.
• the first component is at least one selected from the group consisting of glycyrrhizic acid and its salts, salicylic acid and its salts, and vegetable extracts.
• adenosine is dissolved in an aqueous solvent in an environment of 25 ° C. or higher even if the ethanol content is low. Further, in the adenosine-containing composition of the present disclosure, adenosine is unlikely to precipitate even when the ambient temperature becomes low, and even if adenosine precipitates at a low temperature, adenosine can be naturally dissolved by an increase in the temperature of the ambient environment.
• the adenosine can be dissolved in an aqueous solvent having a low ethanol content, and the precipitation of the dissolved adenosine can be suppressed. Further, even if adenosine is precipitated due to a decrease in the temperature of the surrounding environment, the adenosine can be naturally dissolved by the increase in the temperature of the surrounding environment.
• the vegetable extracts include asitaba leaf / stem extract, apricot juice, ginkgo biloba extract, unshu mikan peel extract, ginger root extract, tanen carrot root extract, canina rose fruit extract, ononis extract, and elephant root.
• Extract Kihada bark extract, Clara root extract, Sakura leaf extract, Otogirisou flower / leaf / stem extract, Seiyosanzashi flower extract, Seiyotochinoki seed extract, Seiyounokogirisou extract, Sentifolia rose flower extract, Someiyoshino leaf extract, Tsubaki seed extract , Tsubaki flower extract, Tencha extract, Hass germ extract, Futomomo leaf extract, Mishima psycho root extract, Merilot extract, Yagurumagiku flower extract, Lemon extract, Rosemary extract, Rosemary leaf extract, Wild thyme extract, and Waremoko extract. At least one selected.
• the content of the component (A) is 5 ⁇ 10 -4 % by mass to 8% by mass with respect to the mass of the adenosine-containing composition.
• the component (B) is a component that suppresses the precipitation of the dissolved component (A).
• the component (B) further contains caffeine.
• the content of the component (B) is 1 ⁇ 10 -4 % by mass or more with respect to the mass of the adenosine-containing composition.
• the content of the component (C) is 60% by mass or more with respect to the mass of the adenosine-containing composition.
• the adenosine-containing composition further contains 5% by mass to 40% by mass of a polyhydric alcohol with respect to the mass of the adenosine-containing composition.
• the adenosine-containing composition is a one-phase liquid composition.
• the component (A) and the component (B) are dissolved in the adenosine-containing composition at 25 ° C. under atmospheric pressure.
• the adenosine-containing composition does not substantially contain ethanol.
• the adenosine-containing composition is applied to a skin external preparation applied to the skin.
• the adenosine-containing composition is a skin external preparation for application to the scalp.
• water in the aqueous solvent, water is 60% by mass or more with respect to the mass of the aqueous solvent.
• the vegetable extracts include asitaba leaf / stem extract, apricot juice, ginkgo biloba extract, unshu mikan peel extract, ginger root extract, tanen carrot root extract, canina rose fruit extract, ononis extract, and elephant root.
• Extract Kihada bark extract, Clara root extract, Sakura leaf extract, Otogirisou flower / leaf / stem extract, Seiyosanzashi flower extract, Seiyotochinoki seed extract, Seiyounokogirisou extract, Sentifolia rose flower extract, Someiyoshino leaf extract, Tsubaki seed extract , Tsubaki flower extract, Tencha extract, Hass germ extract, Futomomo leaf extract, Mishima psycho root extract, Merilot extract, Yagurumagiku flower extract, Lemon extract, Rosemary extract, Rosemary leaf extract, Wild thyme extract, and Waremoko extract. At least one selected.
• adenosine is added in an amount of 5 ⁇ 10 -4 % by mass to 8% by mass based on the total mass of the composition.
• the first component is a component that suppresses the precipitation of dissolved adenosine.
• the first component further contains caffeine.
• the first component is added in an amount of 1 ⁇ 10 -4 % by mass or more based on the total mass of the composition.
• the method for suppressing the precipitation of adenosine is further a step of adding 5% by mass to 40% by mass of a polyhydric alcohol to the aqueous solvent with respect to the total mass of the composition.
• a one-phase liquid composition in which the component (A) and the component (B) are dissolved is produced.
• the step of adding ethanol is not included.
• the "substantial amount” means an amount in which the action and effect of the addition of the compound can occur.
• POE is an abbreviation for polyoxyethylene and POP is an abbreviation for polyoxypropylene, and the number in parentheses after POE or POP represents the average number of moles of POE group or POP group added in the compound.
• the adenosine-containing composition according to the first embodiment of the present disclosure will be described.
• the adenosine-containing composition of the present disclosure comprises at least one selected from the group consisting of (A) adenosine, (B) caffeine, glycyrrhizinic acid and its salt, salicylic acid and its salt, and a vegetable extract (extract). , (C) Water and.
• the adenosine-containing composition is a liquid composition.
• the adenosine-containing composition is preferably a one-phase aqueous composition.
• the adenosine-containing composition can also be an emulsion containing an oily component.
• the adenosine is dissolved in the adenosine-containing composition at 25 ° C. under atmospheric pressure (preferably at 25 ° C. for 4 weeks or more after the adenosine is precipitated in a low temperature environment). Whether or not adenosine is dissolved can be determined by visually observing the appearance.
• the content of adenosine is preferably 5 ⁇ 10 -4 % by mass or more with respect to the mass of the adenosine-containing composition.
• the content of adenosine is 8 ⁇ 10 -4 % by mass or more, 1 ⁇ 10 -3 % by mass or more, 5 ⁇ 10 -3 % by mass or more, and 1 ⁇ 10 ⁇ 2 mass% with respect to the mass of the adenosine-containing composition.
• the content of adenosine is preferably 8% by mass or less with respect to the mass of the adenosine-containing composition.
• the content of adenosine is 5% by mass or less, 4% by mass or less, 3.5% by mass or less, 3% by mass or less, 2.5% by mass or less, 2% by mass or less, based on the mass of the adenosine-containing composition. It can be 1.5% by mass or less, or 1% by mass or less. If the content of adenosine exceeds 8% by mass, adenosine is likely to precipitate.
• the adenosine-containing composition of the present disclosure contains at least one component selected from the group consisting of caffeine, glycyrrhizic acid and salts thereof, salicylic acid and salts thereof, and vegetable extracts.
• these components are referred to as precipitation-suppressing components.
• the precipitation-suppressing component suppresses the precipitation of adenosine dissolved in the solvent, or even if adenosine is temporarily precipitated in the composition in a low temperature environment (for example, 0 ° C.), the composition is returned to 25 ° C. or higher.
• the precipitation-suppressing component is dissolved in the adenosine-containing composition at 25 ° C. under atmospheric pressure.
• a component that solubilizes the precipitation-inhibiting component such as a surfactant, can be added.
• Vegetable extracts include Ashitaba leaf / stem extract, Anzu juice, Ginkgo biloba extract, Unshu mikan peel extract, Ogon root extract, Otanen carrot root extract, Canina rose fruit extract, Ononis extract, Kanzo root extract, Kihada bark extract, Clara root extract, Sakura.
• Leaf extract Otogirisou flower / leaf / stem extract, Seiyosanzashi flower extract, Seiyotochinoki seed extract, Seiyounokogirisou extract, Sentifolia rose flower extract, Someiyoshino leaf extract, camellia seed extract, camellia flower extract, tencha extract, lotus germ extract , Futomomo leaf extract, Mishima psycho root extract, Merilot extract, Yagurumagiku flower extract, Lemon extract, Rosemary extract, Rosemary leaf extract, Wild thyme extract, and Waremoko extract.
• the above botanical extract is described by the name of the cosmetic ingredient. Even a plant extract having a quasi-drug ingredient name different from the cosmetic ingredient name may be included in the vegetable extract if the INCI name is the same.
• the adenosine-containing composition can contain a plurality of precipitation-suppressing components in any combination.
• the precipitation-suppressing component consists of caffeine, glycyrrhizic acid and its salt, salicylic acid and its salt, apricot juice, ginkgo biloba extract, citrus root extract, clara root extract, camellia flower extract, lemon extract, wild thyme extract, and crackle extract. It is more preferable to include at least one component selected from the group.
• the plant extract can be obtained by immersing the whole plant such as the leaves of the plant, stems including underground stems, fruits, roots, etc. together with an extraction solvent, heating and refluxing the plant, filtering the plants, and concentrating the plants.
• the extraction solvent may be any solvent as long as it is usually used for extraction, and in particular, alcohols such as methanol and ethanol, hydrous alcohols, organic solvents such as acetone and ethyl acetate ester can be used alone or in combination, and water can be used. You can also extract with.
• the content of the precipitation-suppressing component is preferably 1 ⁇ 10 -4 % by mass or more with respect to the mass of the adenosine-containing composition.
• the content of the precipitation inhibitor is 2 ⁇ 10 -4 % by mass or more, 5 ⁇ 10 -4 % by mass or more, 8 ⁇ 10 -4 % by mass or more, and 1 ⁇ 10 -3 with respect to the mass of the adenosine-containing composition.
• Mass% or more 2 ⁇ 10 -3 mass% or more, 3 ⁇ 10 -3 mass% or more, 5 ⁇ 10 -3 mass% or more, 8 ⁇ 10 -3 mass% or more, 0.01 mass% or more, 0.02 It can be mass% or more, 0.05 mass% or more, or 0.07 mass% or more. If the content of the precipitation-suppressing component is less than 1 ⁇ 10 -4 % by mass, the effect of suppressing the precipitation of adenosine cannot be obtained.
• the precipitation suppressing component can be added up to the solubility.
• the content of the precipitation suppressing component is, for example, 1.5% by mass or less, 1% by mass or less, 0.8% by mass or less, 0 with respect to the mass of the adenosine-containing composition with respect to the mass of the adenosine-containing composition. .5% by mass or less, 0.2% by mass or less, 0.1% by mass or less, 0.05% by mass or less, 0.02% by mass or less, 0.01% by mass or less, or 5 ⁇ 10 -3 % by mass or less Can be.
• caffeine, glycyrrhizic acid and its salt, salicylic acid and its salt can be 0.01% by mass or more, preferably 0.05% by mass or more, respectively, with respect to the mass of the adenosine-containing composition.
• the vegetable extract is 5 ⁇ 10 -4 % by mass or more, preferably 1 ⁇ 10 -3 % by mass or more, and more preferably 2 ⁇ 10 -3 % by mass or more, respectively, with respect to the mass of the adenosine-containing composition. be able to.
• the content of the plant extract is a numerical value based on the pure content.
• the precipitation suppressing component is preferably 0.001 part by mass or more with respect to 1 part by mass of adenosine.
• the precipitation inhibitor is 0.002 parts by mass or more, 0.005 parts by mass or more, 0.008 parts by mass or more, 0.01 parts by mass or more, 0.05 parts by mass or more, or 0 with respect to 1 part by mass of adenosine. . It can be 1 part by mass or more. If the precipitation suppressing component is less than 0.001 part by mass, the precipitation suppressing effect is lowered.
• the precipitation suppressing component is 2000 parts by mass or less, 1000 parts by mass or less, 500 parts by mass or less, 200 parts by mass or less, 100 parts by mass or less, 50 parts by mass or less, 20 parts by mass or less, 10 parts by mass with respect to 1 part by mass of adenosine.
• the number may be 5 parts or less, or 1 part by mass or less.
• water used for cosmetics, quasi-drugs and the like can be used, and for example, purified water, ion-exchanged water, tap water and the like can be used.
• the water content is, for example, 30% by mass or more, 40% by mass or more, 50% by mass or more, 60% by mass or more, 65% by mass or more, 70% by mass or more, 75% by mass with respect to the mass of the adenosine-containing composition. % Or more, or 80% by mass or more.
• the water content can be, for example, 95% by mass or less, 90% by mass or less, 85% by mass or less, or 80% by mass or less with respect to the mass of the adenosine-containing composition.
• the adenosine-containing composition of the present disclosure can further contain a polyhydric alcohol.
• the compounds listed below can be used as the polyhydric alcohol.
• propylene glycol, dipropylene glycol, 1,3-butylene glycol and the like are preferable.
• these polyhydric alcohols are added, the solubility of adenosine and the effect of suppressing precipitation can be enhanced.
• the content of the polyhydric alcohol is, for example, 5% by mass or more, 10% by mass or more, 15% by mass or more, 20% by mass or more, 25% by mass or more, 30% by mass or more, based on the mass of the adenosine-containing composition. Alternatively, it can be 40% by mass or more.
• the content of the polyhydric alcohol is, for example, 50% by mass or less, 40% by mass or less, 35% by mass or less, 30% by mass or less, 25% by mass or less, or 20% by mass or less with respect to the mass of the adenosine-containing composition. Can be.
• polyhydric alcohol examples include divalent alcohols (eg, ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, tetramethylene glycol, 2,3-butylene glycol, and the like.
• divalent alcohols eg, ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, tetramethylene glycol, 2,3-butylene glycol, and the like.
• Divalent alcohol alkyl ethers eg, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, diethylene glycol butyl ether, diethylene glycol methyl ethyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl).
• Ether propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monobutyl ether, propylene glycol isopropyl ether, dipropylene glycol methyl ether, dipropylene glycol ethyl ether, dipropylene glycol Cole butyl ether, etc.); Dihydric alcohol ether esters (eg, ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether acetate, ethylene glycol monobutyl ether acetate, ethylene glycol monophenyl ether acetate, ethylene glycol diazibate, ethylene glycol dissuccinate) , Diethylene glycol monoethyl ether acetate, diethylene glycol monobutyl ether acetate, propylene glycol monomethyl ether acetate, propylene glycol monoethyl ether acetate, propylene glycol monopropyl ether acetate, propy
• Sugar alcohols eg, sorbitol, martitol, maltotriose, mannitol,
• ethanol is less than 20% by mass, preferably 15% by mass or less, more preferably 10% by mass or less, and 5% by mass, based on the mass of the adenosine-containing composition.
• the following is more preferable, 3% by mass or less is more preferable, 2% by mass or less is more preferable, and 1% by mass or less is more preferable, and it is substantially not contained in the adenosine-containing composition (0). Mass%) is more preferable.
• mass% is more preferable.
• irritation to the skin can be reduced.
• the adenosine-containing composition can be applied to a person who is hypersensitive to ethanol and / or a person who has an allergic reaction.
• the adenosine-containing compositions of the present disclosure include other components, such as water-soluble alcohols, oily components, powders, anionic surfactants, cationic surfactants, amphoteric surfactants, to the extent that they do not interfere with the effects of the present disclosure.
• Hydrophilic nonionic surfactant, lipophilic nonionic surfactant, thickener, moisturizer, film agent, oil-soluble UV absorber, water-soluble UV absorber, metal ion sequestering agent, amino acid, organic amine , Polymer emulsion, pH adjuster, skin nutrient, vitamin, antioxidant, antioxidant aid, fragrance and the like can be appropriately contained as needed.
• water-soluble alcohol examples include lower alcohols, polyhydric alcohols, polyhydric alcohol polymers, dihydric alcohol alkyl ethers, dihydric alcohol alkyl ethers, dihydric alcohol ether esters, glycerin monoalkyl ethers, and sugar alcohols. At least one selected from simple sugars, oligo sugars, polysaccharides and derivatives thereof and the like can be mentioned.
• Examples of the lower alcohol include propanol, isopropanol, isobutyl alcohol, t-butyl alcohol and the like.
• Examples of the monosaccharide include trisaccharides (eg, D-glycerylaldehyde, dihydroxyacetone, etc.), tetrasaccharides (eg, D-erythroth, D-elittlerose, D-treose, erythritol, etc.), and the like.
• trisaccharides eg, D-glycerylaldehyde, dihydroxyacetone, etc.
• tetrasaccharides eg, D-erythroth, D-elittlerose, D-treose, erythritol, etc.
• oligosaccharide for example, at least one selected from sucrose, guntianose, umbelliferose, lactose, planteose, isolikunoses, ⁇ , ⁇ -trehalose, raffinose, lycnoses, umbilicin, stachyose, velvascours and the like. Can be mentioned.
• polysaccharides examples include cellulose, quince seed, chondroitin sulfate, starch, galactan, dermatan sulfate, glycogen, Arabic gum, heparan sulfate, hyaluronic acid, tragant gum, keratan sulfate, chondroitin, xanthan gum, mucoitin sulfate, guagam, dextran, and keratosulfate.
• Locust bean gum, succinoglucan, caronic acid and the like can be mentioned at least one.
• the other polyol for example, at least one selected from polyoxyethylene methylglucoside (Glucam E-10), polyoxypropylene methylglucoside (Glucam P-10) and the like can be mentioned.
• oily component for example, liquid fats and oils, solid fats and oils, waxes, hydrocarbons, higher fatty acids, higher alcohols, synthetic ester oils, silicone oils and the like can be used.
• Liquid fats and oils include, for example, avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, southern ka oil, castor oil, and flaxseed oil. , Saflower oil, cottonseed oil, eno oil, soybean oil, peanut oil, teaseed oil, kaya oil, rice bran oil, cinnamon oil, Japanese millet oil, jojoba oil, germ oil, triglycerin and the like.
• solid fats and oils include coconut oil, palm oil, horse fat, hardened palm oil, palm oil, beef fat, sheep fat, hardened beef fat, palm kernel oil, pork fat, beef bone fat, mokurou kernel oil, hardened oil, and beef.
• Examples include leg fat, mokurou, and hydrogenated castor oil.
• waxes examples include honey wax, candelilla wax, cotton wax, carnauba wax, bayberry wax, ibotarou, whale wax, montan wax, lanolin, lanolin, capoc wax, lanolin acetate, liquid lanolin, sugar cane, lanolin fatty acid isopropyl, hexyl laurate, and reduced lanolin.
• Jojobaro hard lanolin, serrac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, POE hydrogenated lanolin alcohol ether and the like.
• hydrocarbon oil examples include liquid paraffin, zokerite, squalane, pristane, paraffin, selecin, squalene, petrolatum, microcrystalline wax and the like.
• Higher alcohols include, for example, linear alcohols (eg, lauryl alcohols, cetyl alcohols, stearyl alcohols, behenyl alcohols, myristyl alcohols, oleyl alcohols, cetostearyl alcohols, etc.); branched chain alcohols (eg, monostearyl glycerin ethers (batyl alcohols)). ), 2-Deciltetradecinol, lanolin alcohol, cholesterol, phytosterol, hexyldodecanol, isostearyl alcohol, octyldodecanol, etc.) can be used.
• linear alcohols eg, lauryl alcohols, cetyl alcohols, stearyl alcohols, behenyl alcohols, myristyl alcohols, oleyl alcohols, cetostearyl alcohols, etc.
• branched chain alcohols eg, monostearyl glycerin ethers (batyl alcohols)
• Synthetic ester oils include isopropyl myristate, cetyl octanate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate.
• silicone oil examples include dimethylpolysiloxane, methylhydrogenpolysiloxane, methylphenylpolysiloxane, stearoxymethylpolysiloxane, polyether-modified organopolysiloxane, fluoroalkyl-polyoxyalkylene co-modified organopolysiloxane, and alkyl-modified organopolysiloxane. , End-modified organopolysiloxane, fluorine-modified organopolysiloxane, amino-modified organopolysiloxane, silicone gel, acrylic silicone, trimethylsiloxysilicate, silicone compounds such as silicone RTV rubber and the like.
• the powder examples include inorganic powders (eg, talc, kaolin, mica, silk mica (serisite), white mica, gold mica, synthetic mica, red mica, black mica, lithia mica, fired mica, fired talc, vermiculite, etc.
• inorganic powders eg, talc, kaolin, mica, silk mica (serisite), white mica, gold mica, synthetic mica, red mica, black mica, lithia mica, fired mica, fired talc, vermiculite, etc.
• Natural pigments eg, chlorophyll, ⁇ -carotene, etc.
• Wax powder eg, carnauba wax powder, etc.
• Starch powder eg, corn starch powder, rice starch powder, etc.
• a surfactant can be added to dissolve such components.
• the surfactant an amount necessary for dissolving the component insoluble in the aqueous solvent in the solvent may be added. It is preferable that the content of the surfactant is low in order to reduce irritation to the skin and to suppress stickiness due to application.
• the content of the surfactant is preferably 1% by mass or less with respect to the mass of the adenosine-containing composition.
• anionic surfactant examples include fatty acid sequent (eg, sodium laurate, sodium palmitate, etc.); higher alkyl sulfate ester salts (eg, sodium lauryl sulfate, potassium lauryl sulfate, etc.); alkyl ether sulfate (eg, sodium lauryl sulfate, etc.).
• POE-sodium lauryl sulfate triethanolamine POE-sodium lauryl sulfate, etc.
• N-acylsarcosic acid eg, sodium lauroyl sulcosin, etc.
• higher fatty acid amide sulfonate eg, N-stearoyl-N-methyltaurine sodium, etc.
• Phosphate ester salts POE-oleyl ether phosphate sodium, POE-stearyl ether phosphoric acid, etc.
• Triethanolamine sulfonate Triethanolamine
• cationic surfactant examples include alkyltrimethylammonium salts (eg, stearyltrimethylammonium chloride, lauryltrimethylammonium chloride, etc.); alkylpyridinium salts (eg, cetylpyridinium chloride, etc.); dialkyldimethylammonium salts (eg, disstearyl chloride, etc.).
• alkyltrimethylammonium salts eg, stearyltrimethylammonium chloride, lauryltrimethylammonium chloride, etc.
• alkylpyridinium salts eg, cetylpyridinium chloride, etc.
• dialkyldimethylammonium salts eg, disstearyl chloride, etc.
• amphoteric surfactant examples include imidazoline-based amphoteric surfactants (eg, 2-undesyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroki. Side-1-carboxyethyroxy 2-sodium salt, etc.); Betaine-based surfactants (eg, 2-heptadecyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, lauryldimethylaminoacetic acid betaine, alkylbetaine, amide betaine) , Sulfobetaine, etc.) and the like.
• imidazoline-based amphoteric surfactants eg, 2-undesyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroki. Side-1-carboxyethyroxy
• hydrophilic non-ionic surfactant examples include POE-sorbitan fatty acid esters (eg, POE-sorbitan monooleate, POE-sorbitan monostearate, POE-sorbitan monooleate, POE-sorbitan tetraoleate, etc.); POE-Solbit fatty acid ester (eg, POE-Sorbit monolaurate, POE-Sorbit monooleate, POE-Sorbit pentaoleate, POE-Sorbit monostearate, etc.); POE-glycerin fatty acid ester (eg, POE-glycerin mono) POE-monooleates such as stearate, POE-glycerin monoisostearate, POE-glycerin triisostearate, etc.); POE-fatty acid esters (eg, POE-distearate, POE-monodiolate, ethylene glycol distearate, etc.); POE-
• lipophilic nonionic surfactant examples include sorbitan fatty acid esters (eg, sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan.
• sorbitan fatty acid esters eg, sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan.
• Trioleate penta-2-ethylhexylate diglycerol sorbitan, tetra-2-ethylhexylate diglycerol sorbitan, etc.; , ⁇ , ⁇ '-Glycerin pyroglutamate oleate, Glycerin monostearate, malic acid, etc.); Propropylene glycol fatty acid ester (eg, propylene glycol monostearate, etc.); Hardened castor oil derivative; Glycerin alkyl ether and the like.
• Natural water-soluble polymers include, for example, plant-based polymers (eg, arabic gum, tragacanto gum, galactan, guar gum, carob gum, karaya gum, carrageenan, pectin, canten, quince seed (malmero), algae colloid (cassow extract), starch (eg, Rice, corn, potato, wheat), glycyrrhizinic acid); Micromolecular polymers (eg, xanthan gum, dextran, succinoglucan, pullulan, etc.); Animal polymers (eg, collagen, casein, albumin, gelatin, etc.) Can be mentioned.
• plant-based polymers eg, arabic gum, tragacanto gum, galactan, guar gum, carob gum, karaya gum, carrageenan, pectin, canten, quince seed (malmero), algae colloid (cassow extract), starch (eg, Rice, corn, potato, wheat), glycyr
• Examples of the semi-synthetic water-soluble polymer include a starch-based polymer (for example, carboxymethyl starch, methyl hydroxypropyl starch, etc.); a cellulose-based polymer (methyl cellulose, ethyl cellulose, methyl hydroxypropyl cellulose, hydroxyethyl cellulose, sodium cellulose sulfate, etc.). Hydroxypropyl cellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose, crystalline cellulose, cellulose powder, etc.); Examples thereof include alginic acid-based polymers (for example, sodium alginate, propylene glycol alginate, etc.).
• a starch-based polymer for example, carboxymethyl starch, methyl hydroxypropyl starch, etc.
• a cellulose-based polymer methyl cellulose, ethyl cellulose, methyl hydroxypropyl cellulose, hydroxyethyl cellulose, sodium cellulose sulfate, etc.
• thickener examples include Arabic gum, carrageenan, carrageenan, tragacanto gum, carob gum, quince seed (malmero), casein, dextrin, gelatin, sodium pectinate, sodium alginate, methyl cellulose, ethyl cellulose, carboxymethyl cellulose (CMC), hydroxyethyl cellulose.
• Hydroxypropyl cellulose polyvinyl alcohol (PVA), polyvinyl methyl ether (PVM), PVP (polyvinylpyrrolidone), sodium polyacrylate, carboxyvinyl polymer, locust bean gum, guagam, tamarint gum, dialkyldimethylammonium sulfate cellulose, xanthan gum, kay
• PVA polyvinyl alcohol
• PVM polyvinyl methyl ether
• PVP polyvinylpyrrolidone
• sodium polyacrylate sodium polyacrylate
• carboxyvinyl polymer locust bean gum, guagam, tamarint gum, dialkyldimethylammonium sulfate cellulose, xanthan gum, kay
• examples thereof include aluminum magnesium acid acid, bentonite, hectrite, aluminum magnesium silicate (beagum), laponite, silicic anhydride, taurate-based synthetic polymer, acrylate-based synthetic polymer and the
• moisturizing agent examples include polyethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol, xylitol, sorbitol, martitol, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronic acid, atelocollagen, and cholesteryl-12-hydroxystearate. , Sodium lactate, bile acid salt, dl-pyrrolidone carboxylate, alkylene oxide derivative, short chain soluble collagen, diglycerin (EO) PO adduct, Izayoi rose extract, sardine extract, melilot extract and the like.
• EO diglycerin
• the film agent examples include an anionic film agent (for example, (meth) acrylic acid / (meth) acrylic acid ester copolymer, methyl vinyl ether / anhydrous maleic acid high polymer, etc.), and a cationic film agent (for example, cation).
• an anionic film agent for example, (meth) acrylic acid / (meth) acrylic acid ester copolymer, methyl vinyl ether / anhydrous maleic acid high polymer, etc.
• a cationic film agent for example, cation.
• nonionic film agent for example, polyvinyl alcohol, polyvinylpyrrolidone, polyvinylacetate, polyacrylic acid ester copolymer, (meth) Acrylamide, polymer silicone, silicone resin, trimethylsiloxysilic acid, etc.
• oil-soluble ultraviolet absorber examples include a benzoic acid-based ultraviolet absorber (for example, paraaminobenzoic acid (hereinafter abbreviated as PABA), PABA monoglycerin ester, N, N-dipropoxy PABA ethyl ester, N, N-diethoxyPABA).
• PABA paraaminobenzoic acid
• Ethyl ester N, N-dimethyl PABA ethyl ester, N, N-dimethyl PABA butyl ester, N, N-dimethyl PABA ethyl ester, diethylaminohydroxybenzoyl benzoate hexyl, etc.); Anthranyl acid-based ultraviolet absorbers (eg, homomentyl- N-Acetylanthranilate, etc.); Salicylic acid-based ultraviolet absorbers (eg, ethylhexyl salicylate, amylsalicylate, menthylsalicylate, homomentylsalicylate, octylsalicylate, phenylsalicylate, benzylsalicylate, p-isopropanolphenylsalicylate, homosalate, etc.); Acid-based UV absorbers (eg, octylmethoxysinamate, ethyl-4-isopropyls
• water-soluble ultraviolet absorber examples include a benzophenone-based ultraviolet absorber (for example, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, etc.) and a benzilidenshonou-based ultraviolet absorber (benzilidenshonousulfonic acid, terephthalili). Denjisho-no-sulphonic acid, etc.), phenylbenzoimidazole-based ultraviolet absorbers (phenylbenzimidazole sulfonic acid, etc.) and the like can be mentioned.
• a benzophenone-based ultraviolet absorber for example, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, etc.
• benzilidenshonou-based ultraviolet absorber benzilidenshonousulfonic acid, terephthalili.
• Denjisho-no-sulphonic acid, etc. phenylbenzoimidazole-based ultraviolet absorbers (phenylbenzimidazole sulfonic acid, etc.)
• metal ion sequestering agent examples include 1-hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, disodium edetate, trisodium edetate, and tetrasodium edetate.
• Sodium citrate sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, edetic acid, ethylenediamine hydroxyethyl triacetate trisodium and the like.
• amino acids examples include neutral amino acids (eg, threonine, cysteine, etc.); basic amino acids (eg, hydroxylysine, etc.) and the like.
• amino acid derivative examples include acyl sarcosine sodium (lauroyl sarcosine sodium), acyl glutamate, acyl ⁇ -alanine sodium, glutathione, pyrrolidone carboxylic acid and the like.
• organic amine examples include monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-methyl-1-propanol and the like. Can be mentioned.
• polymer emulsion examples include acrylic resin emulsion, ethylpolyacrylic acid emulsion, acrylic resin liquid, polyacrylic alkyl ester emulsion, polyvinyl acetate resin emulsion, natural rubber latex and the like.
• pH adjuster examples include buffers such as lactic acid-sodium lactate, citric acid-sodium citrate, and succinate-sodium succinate.
• vitamins examples include vitamins A, B1, B2, B6, C, E and their derivatives, pantothenic acid and its derivatives, biotin and the like.
• antioxidants examples include tocopherols, dibutylhydroxytoluene, butylhydroxyanisole, gallic acid esters and the like.
• antioxidant aid examples include phosphoric acid, citric acid, ascorbic acid, maleic acid, malonic acid, succinic acid, fumaric acid, kephalin, hexametaphosphate, phytic acid, ethylenediamine tetraacetic acid and the like.
• compoundable components include, for example, preservatives (ethylparaben, butylparaben, chlorphenesin, phenoxyethanol, etc.); anti-inflammatory agents (eg, glycyrrhizinic acid derivative, glycyrrhetinic acid derivative, salicylic acid derivative, hinokithiol, zinc oxide, allantin, etc.) ); Whitening agents (eg, placenta extract, yukinoshita extract, albutin, etc.); Various extracts (eg, Oubaku, Ouren, Shikon, Shakuyaku, Senburi, Birch, Sage, Biwa, Carrot, Aloe, Zeniaoi, Iris, Grape , Yokuinin, Hechima, Yuri, Saffron, Senkyu, Shokyo, Otogirisou, Ononis, Garlic, Togarashi, Chimpi, Touki, Seaweed, etc.), Activator (eg, Royal Je
• compositions of the present disclosure include caffeine, tannin, verapamil, tranexamic acid and its derivatives, various crude drug extracts such as licorice, carin, ichiyakuso, tocopherol acetate, glycyrrhenic acid, glycyrrhizinic acid and its derivatives or salts thereof.
• a drug, a whitening agent such as vitamin C, magnesium ascorbic acid phosphate, ascorbic acid glucoside, arbutin, and kodiic acid, amino acids such as arginine and lysine, and derivatives thereof can also be appropriately contained.
• adenosine-containing composition of the present disclosure precipitation of adenosine is suppressed. For example, even if the environment is changed from an environment of 25 ° C. or higher to a low temperature environment, the precipitation of adenosine dissolved in the solvent is suppressed. Further, even if adenosine is precipitated in a low temperature environment, the adenosine can be naturally dissolved by allowing the adenosine-containing composition to stand in an environment of 25 ° C. or higher again. This makes it possible to prepare a composition in which adenosine is easily applied to the skin. In addition, treatment such as heating for redissolving the precipitated adenosine becomes unnecessary (change in environmental temperature is not included in the heating referred to here).
• the adenosine-containing composition of the present disclosure does not require ethanol to promote the dissolution of adenosine. Therefore, the content of ethanol can be lowered, and ethanol can not be contained. This makes it possible to apply the adenosine-containing composition to a person whose skin is hypersensitive to ethanol or a person who is allergic to ethanol.
• the adenosine-containing composition of the present disclosure can be applied to a skin external preparation, particularly a skin external preparation applied to the scalp.
• the adenosine-containing composition of the present disclosure can be applied to, for example, a hair restorer, a hair restorer, a hair thickener, a hair growth agent, a hair loss preventive agent, a shampoo, a rinse, a conditioner and the like.
• the precipitation inhibitor is dissolved in an aqueous solvent containing water.
• adenosine is added to an aqueous solvent to dissolve it.
• the adenosine-containing composition of the present disclosure can be prepared.
• the order of addition may be any as long as each component can be dissolved.
• Dissolution of adenosine is preferably carried out in an aqueous solvent at 25 ° C. or higher.
• the adenosine-containing composition of the present disclosure may be difficult to directly identify due to its composition, structure, etc., or may not be practical. In such cases, the adenosine-containing composition of the present disclosure should be allowed to be specified by its production method.
• the method for suppressing the precipitation of adenosine according to the second embodiment of the present disclosure comprises a dissolution step of dissolving adenosine and the first component in an aqueous solvent.
• the first component is at least one selected from the group consisting of caffeine, glycyrrhizic acid and its salts, salicylic acid and its salts, and vegetable extracts.
• the first component corresponds to the precipitation suppressing component referred to in the first embodiment.
• the order of addition of each component may be any.
• the dissolution step it is preferable to dissolve adenosine in an aqueous solvent at 25 ° C or higher.
• the method for suppressing the precipitation of adenosine is to add a second component that solubilizes the first component in the aqueous solvent, such as a surfactant, when the first component is not dissolved in the aqueous solvent in the dissolution step. Further steps can be included.
• the method for suppressing the precipitation of adenosine can further include a step of placing (preserving) the composition prepared in the dissolution step in an environment of room temperature of 25 ° C. or higher. This makes it possible to suppress the precipitation of adenosine. Even if adenosine is precipitated due to a decrease in solubility due to low temperature, natural dissolution of adenosine can be promoted.
• the amount of adenosine added can be the same as in the first embodiment. Regarding the amount of adenosine added, the description of the first embodiment is referred to, and the description thereof is omitted here. It is preferable to dissolve adenosine in an aqueous solvent at 25 ° C. or higher.
• the type of the precipitation suppressing component and the amount thereof added can be the same as in the first embodiment.
• the description of the first embodiment is referred to, and the description thereof is omitted here.
• the aqueous solvent contains water.
• Water can be 60% by mass or more with respect to the mass of the aqueous solvent.
• the amount of water added can be the same as in the first embodiment. Regarding the amount of water added, the description of the first embodiment is referred to, and the description thereof is omitted here.
• Ethanol is less than 20% by mass, preferably 15% by mass or less, more preferably 10% by mass or less, and more preferably 5% by mass or less, based on the total mass of the aqueous solvent or each component. It is more preferably 3% by mass or less, more preferably 2% by mass or less, further preferably 1% by mass or less, and further preferably not substantially contained (0% by mass).
• the method of suppressing the precipitation of adenosine is preferable not to include the step of adding ethanol.
• the method for suppressing the precipitation of adenosine can further include a step of adding a polyhydric alcohol to the aqueous solvent and / or to the composition prepared in the dissolution step.
• the type of the polyhydric alcohol and the amount thereof added can be the same as in the first embodiment.
• the description of the first embodiment is referred to, and the description thereof is omitted here.
• composition prepared by the method for suppressing the precipitation of adenosine is preferably a one-phase liquid composition in which the component (A) and the component (B) are dissolved.
• At least the amount of ethanol used can suppress the precipitation of adenosine dissolved in an aqueous solvent.
• the precipitate can be naturally dissolved and the dissolved state of adenosine at room temperature can be maintained by returning the precipitate to an environment of 25 ° C. or higher.
• treatment such as heating for redissolving the precipitated adenosine becomes unnecessary.
• the adenosine-containing composition and the method for suppressing adenosine precipitation of the present disclosure will be described below with examples. However, the adenosine-containing composition and the adenosine precipitation suppressing method of the present disclosure are not limited to the following examples.
• the unit of the content of each component shown in each table is mass%.
• adenosine-containing composition was made at 25 ° C.
• the adenosine-containing composition immediately after preparation was a one-phase aqueous composition, and the adenosine and the precipitation-suppressing component were dissolved in the composition.
• the prepared adenosine-containing composition was allowed to stand in an environment of 0 ° C. for 4 weeks, and it was visually confirmed whether precipitation occurred in the composition.
• the adenosine-containing composition that had been allowed to stand in the environment of 0 ° C. for 4 weeks was allowed to stand in the environment of 25 ° C. for 7 days, and whether or not the precipitate remained in the composition (the precipitate was redissolved). Was it visually confirmed?
• the test results were evaluated according to the following criteria. A commercially available product was used as the vegetable extract.
• Test Example 36 which did not contain ethanol and a precipitation inhibitory component, adenosine precipitated at 0 ° C. did not redissolve even when the temperature was returned to 25 ° C.
• Test Examples 1 to 35 to which the precipitation inhibitory component was added adenosine did not precipitate even at 0 ° C., or even if it did precipitate, adenosine spontaneously redissolved when the temperature was returned to 25 ° C.
• the precipitation-suppressing component has an action of suppressing the precipitation of adenosine and facilitating the redissolution of the precipitated adenosine (or an action of precipitating adenosine that is easily redissolved).
• Test Examples 37 to 72 Using some of the precipitation-inhibiting components used in Test Examples 1 to 35, a composition in which the content of the precipitation-inhibiting component was changed and a composition in which a plurality of precipitation-inhibiting components were combined were prepared. In some test examples, the amount of adenosine was increased as compared with test examples 1-36. When the precipitation inhibitor and the fragrance were not dissolved in the solvent, a surfactant was added. Immediately after preparation, each of the compositions of Test Examples 37 to 72 was a one-phase aqueous composition, and adenosine and the precipitation-suppressing component were dissolved in the solvent. Tables 3 to 8 show the composition and test results.
• the precipitation suppressing effect could be confirmed in any of Test Examples 37 to 49 in which the content of the precipitation suppressing component was changed. It is considered that the precipitation suppressing component can be 1 ⁇ 10 -4 % by mass or more. Considering the results of Test Examples 1 to 35 together, it was observed that the precipitation suppressing effect tends to be higher when the precipitation suppressing component is increased with respect to adenosine.
• Test Examples 73 to 78 compositions containing ethanol but not a precipitation-suppressing component were prepared. However, after cooling, it was allowed to stand at room temperature for 4 weeks to confirm the presence or absence of precipitation.
• Test Example 79 a composition containing a polyhydric alcohol but not ethanol and a precipitation-suppressing component was prepared.
• Test Example 80 a composition containing a precipitation-suppressing component but not ethanol and a polyhydric alcohol was prepared.
• Test Example 81 a composition containing a precipitation-suppressing component, ethanol and a polyhydric alcohol was prepared.
• Test Examples 76 to 78 having a high ethanol content the effect of suppressing the precipitation of adenosine was high.
• Test Examples 73 to 75 having a low ethanol content the effect of suppressing the precipitation of adenosine was not obtained. Therefore, in a composition that does not contain a precipitation inhibitory component, it is considered that sufficient precipitation inhibition cannot be achieved if ethanol is less than 20% by mass.
• Test Example 79 Even in Test Example 79 using only a polyhydric alcohol, a sufficient effect of suppressing adenosine precipitation was not obtained. According to Test Example 80, it was found that the precipitation suppressing effect by the precipitation suppressing component can be obtained even without ethanol and polyhydric alcohol. According to Test Example 81, it was found that the precipitation suppressing effect by the precipitation suppressing component can be obtained even in the presence of ethanol.
• Test Examples 82 to 85 A composition in which the content of adenosine was changed was prepared. When the precipitation inhibitor was not dissolved in the solvent, a surfactant was added. Immediately after preparation, each of the compositions of Test Examples 82 to 85 was a one-phase aqueous composition, and adenosine and the precipitation-suppressing component were dissolved in the solvent. Table 11 shows the composition and test results.
• adenosine can be 5 ⁇ 10 -4 % by mass or more, preferably 8 ⁇ 10 -4 % by mass or more, based on the mass of the composition. It was also found that adenosine can be 8% by mass or less, preferably 6% by mass or less, based on the mass of the composition.
• compositions with different combinations and contents of plant extracts were prepared. When the precipitation inhibitor was not dissolved in the solvent, a surfactant was added. Immediately after preparation, each of the compositions of Test Examples 86 to 89 was a one-phase aqueous composition, and adenosine and the precipitation-suppressing component were dissolved in the solvent. Table 12 shows the composition and test results.
• the precipitation suppressing effect could be confirmed in any of Test Examples 86 to 89. It is considered that the precipitation inhibitory effect can be obtained even if the plant extract whose adenosine precipitation inhibitory effect is confirmed alone in the above test example is combined. It was also found that the plant extract can be 0.5% by mass or more with respect to the mass of the composition.
• Test Examples 90 to 98 A composition in which a plurality of precipitation-suppressing components were combined was prepared. When the precipitation inhibitor was not dissolved in the solvent, a surfactant was added. Immediately after preparation, each of the compositions of Test Examples 90 to 98 was a one-phase aqueous composition, and adenosine and the precipitation-suppressing component were dissolved in the solvent. Table 13 shows the composition and test results.
• the precipitation suppressing effect could be confirmed even in Test Examples 90 to 98 in which a plurality of precipitation suppressing components were combined. It was found that the precipitation inhibitory effect can be obtained even if the components alone have the adenosine precipitation inhibitory effect, even if they are combined.
• adenosine-containing composition and the adenosine precipitation suppressing method of the present invention are described based on the above-mentioned embodiments and examples, but are not limited to the above-mentioned embodiments and examples, and are within the scope of the present invention. Based on the basic technical idea of the present invention, various modifications, modifications and improvements may be included for each disclosed element (including the elements described in the claims, the specification and the drawings). Further, within the scope of the claims of the present invention, various combinations, substitutions or selections of each disclosed element are possible.
• the vegetable extracts include Ashitaba leaf / stem extract, Anzu juice, Ginkgo biloba extract, Unshu mikan peel extract, Ogon root extract, Otanen carrot root extract, Canina rose fruit extract, Ononis extract, Kanzo root extract, Kihada bark extract, Clara root extract, Sakura leaf extract, pearl oyster flower / leaf / stem extract, pearl oyster flower extract, pearl oyster seed extract, pearl oyster extract, centifolia rose flower extract, someiyoshino leaf extract, camellia seed extract, camellia flower extract, tencha extract, lotus germ Addendum, which is at least one selected from the group consisting of extract, Futomomo leaf extract, Mishima psycho root extract, Merilot extract, Yagurumagiku flower extract, lemon extract, rosemary extract, rosemary leaf extract, wild thyme extract, and crackle extract.
• [Appendix 6] The adenosine-containing composition according to the appendix, wherein the content of the component (C) is 60% by mass or more with respect to the mass of the adenosine-containing composition.
• Appendix 7] The adenosine-containing composition according to the appendix, further comprising a polyhydric alcohol in an amount of 5% by mass to 40% by mass based on the mass of the adenosine-containing composition.
• Appendix 8] It is a one-phase liquid composition and The adenosine-containing composition according to the appendix, wherein the component (A) and the component (B) are dissolved in the adenosine-containing composition at 25 ° C. under atmospheric pressure.
• [Appendix 9] The adenosine-containing composition according to the appendix, which is substantially free of ethanol.
• Appendix 10 The adenosine-containing composition according to the appendix, which is applied to a skin external preparation applied to the skin.
• Appendix 11 The adenosine-containing composition according to the appendix, which is an external skin preparation for application to the scalp.
• Appendix 12 Including a step of dissolving adenosine and the first component in an aqueous solvent containing less than 20% by mass of ethanol.
• the first component is at least one selected from the group consisting of caffeine, glycyrrhizic acid and its salt, salicylic acid and its salt, and a vegetable extract, a method for suppressing the precipitation of adenosine.
• Appendix 13 The method according to the appendix, wherein in the aqueous solvent, water is 60% by mass or more with respect to the mass of the aqueous solvent.
• the vegetable extracts include Ashitaba leaf / stem extract, Anzu juice, Ginkgo biloba extract, Unshu mikan peel extract, Ogon root extract, Otanen carrot root extract, Canina rose fruit extract, Ononis extract, Kanzo root extract, Kihada bark extract, Clara root extract, Sakura leaf extract, pearl oyster flower / leaf / stem extract, pearl oyster flower extract, pearl oyster seed extract, pearl oyster extract, centifolia rose flower extract, someiyoshino leaf extract, camellia seed extract, camellia flower extract, tencha extract, lotus germ Addendum, which is at least one selected from the group consisting of extract, Futomomo leaf extract, Mishima psycho root extract, Merilot extract, Yagurumagiku flower extract, lemon extract, rosemary extract, rosemary leaf extract, wild thyme extract, and crackle extract.
• [Appendix 18] The method according to the appendix, further comprising a step of adding 5% by mass to 40% by mass of a polyhydric alcohol to the aqueous solvent with respect to the total mass of the composition.
• [Appendix 19] The method according to the appendix, wherein a one-phase liquid composition in which the component (A) and the component (B) are dissolved is prepared.
• [Appendix 20] The method according to the appendix, which does not include the step of adding ethanol.
• Appendix 21] A method for using an adenosine-containing composition, wherein the adenosine-containing composition of the present disclosure is used as a skin external preparation.
• [Appendix 22] A method for using an adenosine-containing composition, which applies the adenosine-containing composition of the present disclosure to the scalp.
• the adenosine-containing composition and the adenosine precipitation suppressing method of the present disclosure can be applied to external skin preparations, cleansing agents and the like.
• the adenosine-containing composition and the adenosine precipitation suppressing method can be applied to, for example, an external skin preparation and a cleansing agent applied to the scalp and hair.
• the external skin agent and cleansing agent for example, it can be applied to a hair restorer, a hair restorer, a hair thickener, a hair growth agent, a hair loss preventive agent, a shampoo, a rinse, a conditioner and the like.

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