WO2021143951A3 - 秋水仙碱可溶性微针贴片及其制备方法 - Google Patents
秋水仙碱可溶性微针贴片及其制备方法 Download PDFInfo
- Publication number
- WO2021143951A3 WO2021143951A3 PCT/CN2021/080770 CN2021080770W WO2021143951A3 WO 2021143951 A3 WO2021143951 A3 WO 2021143951A3 CN 2021080770 W CN2021080770 W CN 2021080770W WO 2021143951 A3 WO2021143951 A3 WO 2021143951A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- colchicine
- microneedle patch
- preparation
- method therefor
- microneedle
- Prior art date
Links
- IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 title abstract 6
- 229960001338 colchicine Drugs 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 1
- 239000002390 adhesive tape Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 229920002674 hyaluronan Polymers 0.000 abstract 1
- 229960003160 hyaluronic acid Drugs 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Inorganic Chemistry (AREA)
- Rheumatology (AREA)
- Organic Chemistry (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
一种秋水仙碱可溶性微针贴片及其制备方法。该微针贴片包括含药物秋水仙碱的透明质酸微针阵列、基底和医用胶带，微针呈圆锥形或棱锥形结构。药物仅添加于微针针体，减少成本；微针贴片可以指部按压于皮肤，实现快速释药，避免了胃肠道毒副作用，且提高了生物利用度。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010061254.X | 2020-01-19 | ||
| CN202010061254.XA CN113133991B (zh) | 2020-01-19 | 2020-01-19 | 秋水仙碱可溶性微针贴片及其制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2021143951A2 WO2021143951A2 (zh) | 2021-07-22 |
| WO2021143951A3 true WO2021143951A3 (zh) | 2021-09-02 |
Family
ID=76808993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/CN2021/080770 WO2021143951A2 (zh) | 2020-01-19 | 2021-03-15 | 秋水仙碱可溶性微针贴片及其制备方法 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN113133991B (zh) |
| WO (1) | WO2021143951A2 (zh) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113908425A (zh) * | 2021-10-31 | 2022-01-11 | 江苏熙美生物科技有限公司 | 一种快速制备微针贴的方法 |
| CN114732787A (zh) * | 2021-12-30 | 2022-07-12 | 上海中医药大学 | 一种交联环糊精金属有机骨架载槲皮素的纳米药物颗粒及其应用 |
| CN114288277B (zh) * | 2021-12-31 | 2024-05-14 | 广州新济生物医药研究院有限公司 | 一种机械性能和渗透增强的微针贴片及其制备方法 |
| CN114699361B (zh) * | 2022-03-02 | 2023-11-17 | 上海臻上医药科技有限公司 | 一种微针、微针贴片及其制备方法和应用 |
| CN114557954A (zh) * | 2022-03-03 | 2022-05-31 | 澳门大学 | 含有活性微藻的可溶解微针、微针贴片、制备方法和应用 |
| CN114917179A (zh) * | 2022-03-23 | 2022-08-19 | 深圳大学 | 一种具有多级结构的微针载药贴片及其制备方法 |
| CN114917182B (zh) * | 2022-06-13 | 2023-06-13 | 南京大学 | 一种可即时分离的缓释微针贴片及其制备方法 |
| CN115337530B (zh) * | 2022-09-05 | 2024-09-20 | 安徽中医药大学 | 一种秋水仙碱水凝胶微针及其制备方法 |
| CN115737526A (zh) * | 2022-11-10 | 2023-03-07 | 浙江理工大学 | 血尿酸调控用微针贴片及其制备方法 |
| CN116059520A (zh) * | 2023-01-07 | 2023-05-05 | 兰州大学 | 一种具有pH响应的双层可溶性微针贴片及其制备方法与应用 |
| CN116650477B (zh) * | 2023-06-14 | 2023-11-10 | 黑龙江迪龙制药有限公司 | 用于抗血小板聚集的含奥扎格雷钠的药物组合物及其制备方法 |
| CN116440062B (zh) * | 2023-06-15 | 2023-09-26 | 北京市心肺血管疾病研究所 | 一种搭载左西孟旦用于治疗心力衰竭的可溶性微针贴片及其制备方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101062022A (zh) * | 2007-05-31 | 2007-10-31 | 天津市中宝制药有限公司 | 治疗急性痛风的秋水仙碱透皮吸收贴剂及其制备方法 |
| EP2005990A2 (en) * | 2006-04-07 | 2008-12-24 | Hisamitsu Pharmaceutical Co., Inc. | Microneedle device and transdermal administration device provided with microneedles |
| CN103251550A (zh) * | 2012-02-20 | 2013-08-21 | 上海市计划生育科学研究所 | 含有秋水仙碱的透皮给药膏剂及其制备方法 |
| CN108057018A (zh) * | 2016-11-08 | 2018-05-22 | 北京人福军威医药技术开发有限公司 | 秋水仙碱外用组合物及其制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107349175A (zh) * | 2017-06-06 | 2017-11-17 | 浙江理工大学 | 一种负载脂肪褐变剂的微针贴片及其制备方法 |
| CN109528695B (zh) * | 2019-01-12 | 2022-04-19 | 蚌埠医学院 | 一种治疗类风湿性关节炎的微针透皮给药贴片及其制备方法 |
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2020
- 2020-01-19 CN CN202010061254.XA patent/CN113133991B/zh active Active
-
2021
- 2021-03-15 WO PCT/CN2021/080770 patent/WO2021143951A2/zh active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2005990A2 (en) * | 2006-04-07 | 2008-12-24 | Hisamitsu Pharmaceutical Co., Inc. | Microneedle device and transdermal administration device provided with microneedles |
| CN101062022A (zh) * | 2007-05-31 | 2007-10-31 | 天津市中宝制药有限公司 | 治疗急性痛风的秋水仙碱透皮吸收贴剂及其制备方法 |
| CN103251550A (zh) * | 2012-02-20 | 2013-08-21 | 上海市计划生育科学研究所 | 含有秋水仙碱的透皮给药膏剂及其制备方法 |
| CN108057018A (zh) * | 2016-11-08 | 2018-05-22 | 北京人福军威医药技术开发有限公司 | 秋水仙碱外用组合物及其制备方法 |
Non-Patent Citations (3)
| Title |
|---|
| CHEN ZHIWEI, HAN BIN, LIAO LANGKUN, HU XUGUANG, HU QIAOHONG, GAO YUNHUA, QIU YUQIN: "Enhanced transdermal delivery of polydatin via a combination of inclusion complexes and dissolving microneedles for treatment of acute gout arthritis", JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, vol. 55, 1 February 2020 (2020-02-01), FR, pages 101487, XP055840880, ISSN: 1773-2247, DOI: 10.1016/j.jddst.2019.101487 * |
| QIU-HONG CHEN, SHI-XIANG HOU, WEST: "Influence of gel vehicle and penetration enhancer on transdermal resorption of colchicine", HUAXI YAOXUE ZAZHI - WEST CHINA JOURNAL OF PHARMACEUTICALSCIENCES, ZHONGGUO YAOXUEHUI, SICHUAN FENHUI, CHENGDU, CN, vol. 20, no. 6, 31 December 2005 (2005-12-31), CN, pages 521 - 523, XP055840865, ISSN: 1006-0103 * |
| ZHANG YUJIA, ZHANG NAN, SONG HUI, LI HE, WEN JIN, TAN XIAOCHUAN, ZHENG WENSHENG: "Design, characterization and comparison of transdermal delivery of colchicine via borneol-chemically-modified and borneol-physically-modified ethosome", DRUG DELIVERY, vol. 26, no. 1, 1 January 2019 (2019-01-01), US, pages 70 - 77, XP055840888, ISSN: 1071-7544, DOI: 10.1080/10717544.2018.1559258 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN113133991B (zh) | 2023-06-13 |
| WO2021143951A2 (zh) | 2021-07-22 |
| CN113133991A (zh) | 2021-07-20 |
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