WO2021085591A1 - 香料組成物 - Google Patents
香料組成物 Download PDFInfo
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- WO2021085591A1 WO2021085591A1 PCT/JP2020/040782 JP2020040782W WO2021085591A1 WO 2021085591 A1 WO2021085591 A1 WO 2021085591A1 JP 2020040782 W JP2020040782 W JP 2020040782W WO 2021085591 A1 WO2021085591 A1 WO 2021085591A1
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- Prior art keywords
- odor
- group
- octen
- octadien
- olfactory receptor
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Classifications
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- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/20—Synthetic spices, flavouring agents or condiments
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
- G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
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- G—PHYSICS
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- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Definitions
- Composition. [2] The olfactory receptor polypeptide comprises an amino acid sequence having at least 80% identity with (a) OR2C1 and (b) OR2C1 and an amino acid sequence, trans-2-nonenal, trans-2-octenal, 1 -At least one malodor-causing substance selected from the group consisting of octene-3-one, 1,5-octadien-3-one, 1-octen-3-ol, and 1,5-octadien-3-ol.
- a fragrance composition containing a seed fragrance component containing a seed fragrance component.
- Group A 2-methyl-4- (2,2,3-trimethylcyclopent-3-enyl) but-2-en-1-ol, 1- (2,2,6-trimethylcyclohexyl) hexane-3- All, 1,4-dioxacycloheptadecane-5,17-dione, eucalyptus oil, patchouli oil, vetiver oil [9]
- the fragrance component further contains at least one selected from the group consisting of the following group B.
- fragrance composition the product, and the method for suppressing malodor of the present invention will be specifically described together with the screening method for the malodor suppressing material used in the present invention.
- olfactory receptor polypeptide selected from the group consisting of responsive polypeptides To at least one olfactory receptor polypeptide selected from the group consisting of responsive polypeptides, the test substance and 1,5-octadien-3-one are added; To measure the response of the olfactory receptor polypeptide to the 1,5-octadien-3-one; Identifying a test substance that suppresses the response of the olfactory receptor polypeptide based on the measured response, that is, a test substance that suppresses the response of the olfactory receptor polypeptide based on the measured response is 1 , 5-Octadien-3-one Identification as a candidate substance for olfactory inhibitory material, It is characterized by including.
- the N-terminal 20 amino acid residue of bovine rhodopsin may be incorporated together with the olfactory receptor polypeptide.
- the N-terminal 20 amino acid residue of bovine rhodopsin By incorporating the N-terminal 20 amino acid residue of bovine rhodopsin, cell membrane expression of the olfactory receptor polypeptide can be promoted.
- Usyrhodopsin is registered with GenBank as NM_001014890.
- Usyrhodopsin is a polypeptide consisting of an amino acid sequence (SEQ ID NO: 6) encoded by the DNAs of positions 1 to 1047 of the nucleotide sequence shown in SEQ ID NO: 5.
- the time for contacting the olfactory receptor polypeptide with 1-octen-3-ol cannot be unequivocally determined because it depends on the concentration of 1-octen-3-ol and the measurement method. It may be measured, usually 0 to 4 hours, preferably 2 to 4 hours. The same applies when the test substance is mixed with 1-octen-3-ol and brought into contact with the olfactory receptor polypeptide.
- a candidate substance for a 1-octen-3-ol odor suppressing material can be screened from the test substances.
- a candidate substance for a 1-octen-3-ol odor suppressing material is selected from a large number of test substances without causing problems such as olfactory fatigue due to sensory evaluation performed by human olfaction and individual differences. be able to.
- the selected substance can be used as a candidate substance for the 1-octen-3-ol odor suppressing material. It is also possible to develop a new compound having an optimum odor by modifying the selected substance as necessary based on the selected substance.
- the amino acid sequence comprises 80% or more identity with the amino acid sequence of OR2C1, OR4Q3, and any of these polypeptides, and is responsive to 1,5-octadien-3-ol.
- the olfactory receptor polypeptide selected from the group consisting of the polypeptides showing the above is brought into contact with 1,5-octadien-3-ol, and the response of the olfactory receptor polypeptide to 1,5-octadien-3-ol is measured. ..
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
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- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Emergency Medicine (AREA)
- Nutrition Science (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20880569.7A EP4052761A4 (de) | 2019-11-01 | 2020-10-30 | Duftstoffzusammensetzung |
| US17/772,336 US20220378689A1 (en) | 2019-11-01 | 2020-10-30 | Fragrance or flavor composition |
| JP2021553716A JPWO2021085591A1 (de) | 2019-11-01 | 2020-10-30 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019200173 | 2019-11-01 | ||
| JP2019200172 | 2019-11-01 | ||
| JP2019-200173 | 2019-11-01 | ||
| JP2019-200172 | 2019-11-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2021085591A1 true WO2021085591A1 (ja) | 2021-05-06 |
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ID=75715217
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|---|---|---|---|
| PCT/JP2020/040782 WO2021085591A1 (ja) | 2019-11-01 | 2020-10-30 | 香料組成物 |
| PCT/JP2020/040781 WO2021085590A1 (ja) | 2019-11-01 | 2020-10-30 | 悪臭抑制素材のスクリーニング方法 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/JP2020/040781 WO2021085590A1 (ja) | 2019-11-01 | 2020-10-30 | 悪臭抑制素材のスクリーニング方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20220411884A1 (de) |
| EP (2) | EP4052761A4 (de) |
| JP (2) | JPWO2021085591A1 (de) |
| WO (2) | WO2021085591A1 (de) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022224708A1 (ja) * | 2021-04-23 | 2022-10-27 | 高砂香料工業株式会社 | 香料組成物および飲食品 |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004203839A (ja) * | 2002-12-26 | 2004-07-22 | Takasago Internatl Corp | 鉄錆臭抑制香料組成物 |
| JP2012050411A (ja) | 2010-09-03 | 2012-03-15 | Kao Corp | 悪臭抑制剤の探索方法 |
| JP2014240441A (ja) * | 2014-09-29 | 2014-12-25 | 富士化学工業株式会社 | アスタキサンチン含有加齢臭抑制組成物 |
| JP6168999B2 (ja) | 2012-01-31 | 2017-07-26 | 株式会社明治 | 透明容器入り飲食品及びオフフレーバー抑制方法 |
| JP2017153371A (ja) | 2016-02-29 | 2017-09-07 | 小川香料株式会社 | ビール劣化臭抑制剤組成物 |
| JP2017528120A (ja) * | 2014-08-26 | 2017-09-28 | ユニベルシテ ドゥ ジュネーブ | リガンドに対する受容体を同定するための方法およびその使用 |
| WO2019101812A2 (en) * | 2017-11-22 | 2019-05-31 | Firmenich Sa | Method of identifying laundry malodor, moldy malodor and/or sweat malodor modulating compounds |
| WO2019131789A1 (ja) * | 2017-12-27 | 2019-07-04 | 高砂香料工業株式会社 | 加齢臭抑制素材のスクリーニング方法 |
| CN111432851A (zh) * | 2017-11-22 | 2020-07-17 | 弗门尼舍有限公司 | 挥发性成分限制或消除对恶臭的感知的用途 |
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2020
- 2020-10-30 US US17/772,344 patent/US20220411884A1/en active Pending
- 2020-10-30 JP JP2021553716A patent/JPWO2021085591A1/ja active Pending
- 2020-10-30 EP EP20880569.7A patent/EP4052761A4/de active Pending
- 2020-10-30 JP JP2021553715A patent/JPWO2021085590A1/ja active Pending
- 2020-10-30 EP EP20881316.2A patent/EP4052762A4/de active Pending
- 2020-10-30 WO PCT/JP2020/040782 patent/WO2021085591A1/ja unknown
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- 2020-10-30 US US17/772,336 patent/US20220378689A1/en active Pending
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| WO2022224708A1 (ja) * | 2021-04-23 | 2022-10-27 | 高砂香料工業株式会社 | 香料組成物および飲食品 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPWO2021085590A1 (de) | 2021-05-06 |
| US20220411884A1 (en) | 2022-12-29 |
| EP4052762A1 (de) | 2022-09-07 |
| JPWO2021085591A1 (de) | 2021-05-06 |
| EP4052761A4 (de) | 2024-02-21 |
| EP4052761A1 (de) | 2022-09-07 |
| US20220378689A1 (en) | 2022-12-01 |
| WO2021085590A1 (ja) | 2021-05-06 |
| EP4052762A4 (de) | 2024-02-21 |
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