WO2020258310A1 - Système d'analyse d'échantillon - Google Patents

Système d'analyse d'échantillon Download PDF

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Publication number
WO2020258310A1
WO2020258310A1 PCT/CN2019/093884 CN2019093884W WO2020258310A1 WO 2020258310 A1 WO2020258310 A1 WO 2020258310A1 CN 2019093884 W CN2019093884 W CN 2019093884W WO 2020258310 A1 WO2020258310 A1 WO 2020258310A1
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WO
WIPO (PCT)
Prior art keywords
sample
analyzer
detection
crp
sample rack
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PCT/CN2019/093884
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English (en)
Chinese (zh)
Inventor
张军伟
李学荣
郁琦
叶燚
Original Assignee
深圳迈瑞生物医疗电子股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 深圳迈瑞生物医疗电子股份有限公司 filed Critical 深圳迈瑞生物医疗电子股份有限公司
Priority to CN201980095463.1A priority Critical patent/CN113692536B/zh
Priority to PCT/CN2019/093884 priority patent/WO2020258310A1/fr
Publication of WO2020258310A1 publication Critical patent/WO2020258310A1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

Definitions

  • This application relates to the field of medical diagnostic equipment, and in particular to a sample analysis system.
  • CRP C-reactive protein, C-reactive protein
  • CRP C-reactive protein
  • C-reactive protein is an acute phase reactive protein, which is normally present in a small amount in human body fluids, and has varying degrees of elevation in infectious diseases. It has important clinical application value. Especially in recent years, with the rapid development of bedside rapid detection technology, the application of CRP in clinical infectious diseases has become more extensive, and it has once again become the focus of clinical research.
  • Blood routine is one of the three routine examinations, and it is also one of the commonly used auxiliary examination methods for doctors to diagnose the condition; doctors judge the disease by observing the changes in the number and morphological distribution of blood cells.
  • CRP CRP is often used by doctors in conjunction with blood routine tests to distinguish bacterial infections from viral infections due to its simple operation, fast detection speed, and small amount of specimens required.
  • the present application provides a sample analysis system, which adopts a pipeline method, which can greatly improve the efficiency of blood routine and CRP detection.
  • this application provides a sample analysis system, including: a CRP analyzer, a blood cell analyzer, a sample transfer device, and a control device, wherein:
  • the sample transfer device includes: a transfer mechanism with a transfer channel and at least two feed mechanisms with a detection channel, the transfer mechanism is used to transfer a sample rack with a sample container in the transfer channel, each feeding The mechanism is arranged at intervals along the transmission direction of the transmission channel, and the feeding mechanism can transfer the sample rack from the transmission channel to the detection channel and can transfer the sample rack from the detection channel to the transmission channel ;
  • the CRP analyzer and the blood cell analyzer respectively correspond to one feeding mechanism, and the detection area of the CRP analyzer and the blood cell analyzer corresponds to the detection channel of the corresponding feeding mechanism;
  • the CRP analyzer is used to detect the C-reactive protein transferred from the sample transfer device to the sample container on the sample rack in the corresponding detection channel
  • the blood cell analyzer is used to detect the sample transferred from the sample transfer device to the sample container.
  • the blood cell analyzer is located in front of the CRP analyzer;
  • the control device is respectively electrically connected to the CRP analyzer, the blood cell analyzer, and the sample transfer device, and is used to control the sample transfer device to transfer the sample container on the sample rack to the CRP analyzer and/ Or the blood cell analyzer performs detection.
  • this application provides a sample analysis system, including: a CRP analyzer, a blood cell analyzer, a sample transfer device, and a control device, where:
  • the sample transfer device includes: a transfer mechanism with a transfer channel and at least two feed mechanisms with a detection channel, the transfer mechanism is used to transfer the sample rack with the sample container in the transfer channel, each feeding The mechanism is arranged at intervals along the transmission direction of the transmission channel, and the feeding mechanism can transfer the sample rack from the transmission channel to the detection channel and can transfer the sample rack from the detection channel to the transmission channel ;
  • the CRP analyzer and the blood cell analyzer respectively correspond to one feeding mechanism, and the detection area of the CRP analyzer and the blood cell analyzer corresponds to the detection channel of the corresponding feeding mechanism;
  • the CRP analyzer is used to detect the C-reactive protein in the sample in the sample container on the sample rack corresponding to the detection channel by the sample transfer device, and the blood cell analyzer is used to detect the sample transferred to the sample by the sample transfer device.
  • the control device is respectively electrically connected to the CRP analyzer, the blood cell analyzer, and the sample transfer device, and is used to control the sample transfer device to transfer the sample container on the sample rack to the CRP analyzer and/ Or the blood cell analyzer performs detection.
  • the blood cell analyzer In the transmission direction along the transmission channel, the blood cell analyzer is located in front of the CRP analyzer, and the blood cell
  • the analyzer and the CRP analyzer each correspond to a feeding mechanism, and the detection area of the blood cell analyzer and the CRP analyzer corresponds to the detection channel of the respective feeding mechanism, so that for the samples that require routine blood analysis and CRP detection, Driven by the transmission mechanism, the sample rack with the sample container is placed on the transmission channel, first moves to the position of the blood cell analyzer, and is transferred to the detection channel corresponding to the blood cell analyzer by the feeding mechanism corresponding to the blood cell analyzer , Perform blood routine analysis, and then transfer to the transmission channel, and under the drive of the transmission mechanism, to the position of the CRP analyzer, and then transfer to the corresponding CRP analyzer by the feeding mechanism corresponding to the CRP analyzer In the detection channel, CRP analysis is performed. Therefore, the efficiency of blood routine and C
  • Figure 1 is a schematic diagram of a first embodiment provided by the sample analysis system of this application.
  • Figure 2 is a schematic diagram of a second embodiment provided by the sample analysis system of the application.
  • FIG. 3 is a schematic diagram of a third embodiment provided by the sample analysis system of this application.
  • FIG. 4 is a schematic diagram of a fourth embodiment provided by the sample analysis system of the application.
  • FIG. 5 is a schematic diagram of a fifth embodiment provided by the sample analysis system of this application.
  • FIG. 6 is a schematic diagram of a sixth embodiment provided by the sample analysis system of this application.
  • FIG. 7 is a schematic diagram of a seventh embodiment provided by the sample analysis system of this application.
  • FIG. 8 is a schematic diagram of an eighth embodiment provided by the sample analysis system of this application.
  • FIG. 9 is a schematic diagram of a ninth embodiment provided by the sample analysis system of this application.
  • FIG. 10 is a schematic diagram of a tenth embodiment provided by the sample analysis system of this application.
  • FIG. 11 is a schematic diagram of an eleventh embodiment provided by the sample analysis system of this application.
  • FIG. 12 is a schematic diagram of a twelfth embodiment provided by the sample analysis system of this application.
  • Figure 13 is a schematic structural diagram of the loading platform provided by the sample analysis system of the application.
  • FIG. 14 is a schematic diagram of the structure of the loading buffer area provided by the sample analysis system of the application.
  • FIG. 15 is a schematic diagram of the structure of the sample rack provided by the sample analysis system of this application.
  • FIG. 1 is a schematic diagram of a first embodiment provided by the sample analysis system of this application.
  • the sample analysis system includes: a blood cell analyzer 10, a CRP analyzer 20, a sample transfer device and a control device 30.
  • the function of the sample transfer equipment is to transfer the sample rack in which the sample container is placed.
  • the sample transfer equipment includes: a transmission mechanism 41 and at least two feeding mechanisms 42 with detection channels.
  • a transmission channel is formed in the transmission mechanism 41, and the sample rack can be driven by the transmission mechanism to move in the transmission channel.
  • the feeding mechanism 42 is arranged on the side of the conveying channel, and the feeding mechanism 42 is arranged at intervals along the conveying direction X of the conveying channel, and there is an interval between adjacent feeding mechanisms 42.
  • the feeding mechanism 42 is used to transfer the sample
  • the rack is transferred from the transmission channel to the detection channel and the sample rack is transferred from the detection channel to the transmission channel.
  • the transmission mechanism 41 can adopt any one or multiple combinations of chain mechanism, crawler mechanism, belt mechanism, roller mechanism, and track mechanism. If multiple combinations are used, the transmission mechanism 41 can be According to the arrangement of multiple sections of different styles of mechanisms along the transmission channel.
  • the transmission mechanism 41 only needs to be able to complete the transfer of the sample rack, and the shape of the transmission channel is not limited.
  • the transmission channel can be a straight line or a polyline with a certain angle, or It is an arc with a certain radian, or even an irregular shape.
  • the transmission channel may be a flat channel, for example, the upper surface of the belt of the belt mechanism is directly used as the transmission channel; in addition, considering that the sample rack may fall or be twisted during transfer, the transmission channel may also It is a semi-enclosed channel.
  • baffles are provided on both sides of the belt of the belt mechanism, and the top of the baffle is not closed, so that the area enclosed by the baffle forms a semi-enclosed transmission channel, and the sample rack is blocked The restraint of the board will not fall or twist in position.
  • the transmission channel can also be a fully enclosed channel, for example, baffles are provided on both sides and top of the belt of the belt mechanism. In this way, when the sample rack is transferred in the transmission channel, the operator cannot take the sample rack, thereby avoiding the problem of manual intervention.
  • the transmission channel is used as the main channel, and each detection channel is used as the sub-channel.
  • the transmission mechanism 41 can transfer the sample rack to the position of each feeding mechanism 42 on the transmission channel, and then enter The feeding mechanism 42 then transfers the sample rack from the transmission channel to the corresponding detection channel, and the feeding structure 42 can also transfer the sample rack from the detection channel back to the transmission channel.
  • Each analyzer can be provided with a feeding mechanism 42 correspondingly, and the detection channel of each feeding mechanism 42 corresponds to the position of the detection area of the corresponding analyzer, for example, the position of the detection channel and the detection area coincide. This can ensure that when the sample rack is moving in the detection channel, the sample rack can move to the detection area of the analyzer, and then the sample in the sample container on the sample rack can be collected by the analyzer, and the sample can be used for detection and analysis.
  • the feed mechanism 42 may also adopt any one or more combinations of chain mechanism, crawler mechanism, belt mechanism, roller mechanism, and track mechanism. If multiple combinations are used, The feeding mechanism 42 can be provided with a plurality of different types of mechanisms to cooperate.
  • the description of the feeding mechanism please refer to the foregoing description of the transmission mechanism 41 for details. I will not repeat them here.
  • the CRP analyzer 20 and the blood cell analyzer 10 respectively correspond to a feeding mechanism, and the detection area of the CRP analyzer 20 and the blood cell analyzer 10 corresponds to the detection channel of the corresponding feeding mechanism 42. Therefore, the sample in the sample container on the sample rack can be subjected to CRP analysis in the CRP analyzer 20, or, in the blood cell analyzer 10, to perform routine blood analysis.
  • the CRP analyzer 20 is used to detect the C-reactive protein in the sample transferred by the sample transfer device to the sample container on the sample rack in the corresponding detection channel.
  • the blood cell analyzer 10 is used to detect blood cells transferred by the sample transfer device to the sample container on the sample rack in the corresponding detection channel.
  • the blood cell analyzer 10 is located in front of the CRP analyzer 20.
  • front and “rear” are relative concepts, where “front” refers to a position that passes first along the transport direction X, and “rear” refers to a position that passes backward along the transport direction X, and then the blood cell
  • the analyzer 10 is located in front of the CRP analyzer 20, that is, the sample rack on the transmission channel passes through the blood cell analyzer 10 first, and then passes through the CRP analyzer 20.
  • the transmission direction X is from right to left
  • front refers to a position relatively to the right in the figure
  • “rear” refers to a position relatively to the left in the figure. Therefore, in this application, “Front” and “rear” describe the relative positional relationship between the blood cell analyzer 10 and the CRP analyzer 20, rather than a simple understanding of the literal meaning, which should not constitute a limitation to this application.
  • the control device 30 is electrically connected to the CRP analyzer 20, the blood cell analyzer 10, and the sample transfer device.
  • the control device 30 can be a desktop computer, a notebook computer, a single-chip computer, a PDA or other devices with computing capabilities.
  • the control device 30 is used to control the sample transfer device to transfer the sample container on the sample rack to one of the CRP analyzer 20 and the blood cell analyzer 10 for testing, or to transfer to the blood cell analyzer 10 and the CRP analyzer 20 in turn, Both the CRP analyzer 20 and the blood cell analyzer 10 perform corresponding detection on the sample in the sample container. That is, when the sample rack includes samples for blood routine and CRP testing, the control device 30 is used to control the sample transfer device to sequentially transport the sample rack to the blood cell analyzer 10 and the CRP analyzer 20 along the transport direction X.
  • the blood cell analyzer 10 is located in front of the CRP analyzer 20, and the blood cell analyzer 10 and CRP analyzer 20 each correspond to a feeding mechanism 42, and the detection area of the blood cell analyzer 10 and CRP analyzer 20 corresponds to the detection channel of the respective feeding mechanism 42, so that routine blood analysis and CRP are required
  • the sample to be tested, driven by the transmission mechanism 41, the sample rack with the sample container is placed on the transmission channel, first moves to the position where the blood cell analyzer 10 is located, and is transferred by the feeding mechanism 42 corresponding to the blood cell analyzer 10 to and In the detection channel corresponding to the blood cell analyzer 10, routine blood analysis is performed, and then transferred to the transmission channel, and driven by the transmission mechanism 41, to the position of the CRP analyzer 20, and then corresponding to the CRP analyzer 20
  • the feed mechanism 42 of ⁇ is transferred to the detection channel corresponding to the CRP analyze
  • FIG. 2 is a schematic diagram of a second embodiment provided by the sample analysis system of this application.
  • the difference between the second embodiment and the first embodiment is that the sample analysis system further includes a pusher dyeing machine 50.
  • the pusher dyeing machine 50 also corresponds to a feeding mechanism 42, and the detection area of the pusher dyeing machine 50 corresponds to the detection channel of its corresponding feeding mechanism.
  • the sample rack transported on the transport channel can also be moved by the feeding mechanism 42 to the detection area of the slide staining machine 50, so that the slide staining machine 50 performs slide staining processing on the samples in the sample container on the sample rack.
  • the pusher dyeing machine 50 in the transmission direction X along the transmission channel, is located behind the CRP analyzer 20, so that after the CRP detection is completed You can carry out the push-piece dyeing process, as shown in Figure 2.
  • the pusher dyeing machine 50 may also be located between the blood cell analyzer 10 and the CRP analyzer 20, as shown in FIG. 3.
  • the position of the slide dyeing machine 50 can be set freely, as long as the existing detection rules are met.
  • FIG. 4 is a schematic diagram of a fourth embodiment provided by the sample analysis system of this application.
  • the difference between the fourth embodiment and the first embodiment is that the sample analysis system further includes a saccharification meter 60.
  • the saccharification meter 60 Similar to the blood cell analyzer 10 and the CRP analyzer 20, the saccharification meter 60 also corresponds to a feeding mechanism, and the detection area of the saccharification meter 60 corresponds to the detection channel of its corresponding feeding mechanism. In this way, the sample rack transported on the transmission channel can also be moved to the detection area of the saccharification instrument 60 by the feeding mechanism, so that the saccharification instrument 60 performs saccharification detection on the sample in the sample container on the sample rack.
  • the saccharification meter 60 is located behind the CRP analyzer 20. After CRP detection, glycation detection can be performed sequentially, as shown in Figure 4. In addition, in other embodiments of the present application, the saccharification meter 60 may also be located between the blood cell analyzer 10 and the CRP analyzer 20, as shown in FIG. 5.
  • the position of the saccharification meter 60 can be set freely, as long as the existing detection rules are met.
  • FIG. 9 is a schematic diagram of a ninth embodiment provided by the sample analysis system of this application. As shown in FIG. 9, the sample analysis system further includes: a first sample rack identification collector 101.
  • the first sample rack identification collector 101 is used to identify the first sample rack identification collector on the sample rack on the transmission channel.
  • each detection position has a set detection mode.
  • a sample rack that can hold 10 sample containers has 8 detection positions fixed as a detection position with blood routine detection mode , The remaining two detection bits are fixed as detection bits with CRP detection mode.
  • each sample rack can be provided with a sample rack identification mark.
  • the sample rack identification mark can be an image, such as a two-dimensional code, a barcode, a number, etc., or a chip with wireless transmission function, such as an RFID radio frequency. chip. Either way, the role of the sample rack identification is to be identified by other equipment through the collection sample rack identification.
  • the first sample rack identification collector 101 can be an image acquisition device, such as a QR code scanner, etc., or a wireless signal recognizer. , Such as: RFID card reader, etc.
  • the first sample rack identification collector 101 can be set on the transmission channel, and in order to facilitate the identification of the sample rack identification, subsequent analyzers can use the sample rack identification, so the first sample rack
  • the identification collector 101 is located at the front end of the transmission direction X on the transmission channel.
  • control device 30 is electrically connected to the first sample rack identification collector 101. Specifically, the control device 30 may be connected to the first sample rack identification collector 101 through a data cable.
  • the control device 30 stores a first corresponding relationship between the sample rack identifier, the position of the detection position in the sample rack, and the set detection mode of the detection position.
  • the first corresponding relationship is specifically: the sample rack identification a1 of a sample rack, the number of detection positions on a sample rack is 10, and the position numbers of the 10 detection positions are from 1 to 10, where the numbers are
  • the setting detection mode of the detection positions 1 to 8 is the blood routine detection mode
  • the setting detection mode of the detection positions numbered 9 and 10 is the CRP detection mode.
  • the control device 30 is configured to send scheduling instructions to the transmission mechanism 41 and the feeding mechanism 42 according to the first correspondence and the sample rack identifier sent by the first sample rack identifier collector 101, so that the sample rack is transferred to the sample rack. Set the detection position in the analyzer corresponding to the detection mode.
  • the sample analysis system When the sample analysis system provided in the embodiment of the present application works, it is specifically: after the first sample rack identifier collector 101 collects the sample rack identifier, it sends the sample rack identifier to the control device 30, and the control device 30 according to the received
  • the sample rack identification can determine the position of the detection position contained on the sample rack and the set detection mode corresponding to each position, and then the control device 30 can generate scheduling instructions according to the determined content, so that different detection modes
  • the sample rack is transported to the corresponding analyzer, for example: the sample rack with the detection position of the routine blood detection mode is transported to the blood cell analyzer 10 through the transmission mechanism 41 and the feeding mechanism 42, the sample rack with the detection position of the CRP detection mode It is transported to the CRP analyzer 20 through the transmission mechanism 41 and the feeding mechanism 42.
  • the sample rack with the detection position of the blood routine detection mode and the detection position of the CRP detection mode is sequentially transported to the blood cell analysis through the transmission mechanism 41 and the feeding mechanism 42 In the instrument 10 and the CRP analyzer
  • the embodiment of the present application provides the method.
  • the detection position on the sample rack and the detection mode of the detection position can be obtained in advance, and then the sample can be collected according to the information of the sample rack.
  • the rack is accurately transported to the analyzer in the corresponding detection mode, so that the sample rack is pipelined in multiple analyzers corresponding to each detection mode, and the detection efficiency of samples in multiple detection modes that require multiple analyzers to participate is improved.
  • the set detection mode of each detection position on the sample rack can be preset in each analyzer.
  • the analyzer when the sample rack identification is monitored, it can be based on the preset sample
  • the detection mode of each detection position on the rack can be detected in a targeted manner. For example, taking the aforementioned sample rack a as an example, when a sample rack enters the blood cell analyzer 10, the blood cell analyzer 10 will only The samples in the sample containers at the detection positions numbered 1 to 8 are subjected to routine blood testing. While the sample rack a enters the CRP analyzer 20, the CRP analyzer 20 will only perform CRP detection on the samples of the sample containers at the detection positions numbered 9 and 10 on the sample rack.
  • the position of the detection position in the sample rack is preset.
  • the CRP analyzer 20 and the blood cell analyzer 10 may be respectively provided for identifying the target Transfer to the container identification collector with the container identification of the sample container in the sample rack in the corresponding detection channel, and then when the sample container passes through the blood cell analyzer 10 or CRP analyzer 20, the blood cell analyzer 10 or CRP analyzer 20 can use the container
  • the identification collector recognizes the container identification of the sample container.
  • the container identification contains the detection mode information, there is no need to preset the detection position of the sample rack, but the detection mode is obtained through the container identification, and the user can randomly Place the sample container on the sample rack to reduce the difficulty of user operation.
  • the detection mode of each detection position on the sample rack needs to be preset, and the operator is also required to place the sample container according to a predetermined rule, which is prone to errors. Therefore, in the sixth embodiment, the sample rack identifier and the sample container identifier are identified by setting the identifier collector in the analyzer to establish the corresponding relationship between the sample rack and the sample container on the sample rack, so as to achieve more reliable implementation.
  • the blood cell analyzer 10 is provided with a second sample rack identifier collector for identifying the sample rack identifiers in the sample racks that are transferred to the corresponding detection channel, and is also provided for identifying The container identification collector of the container identification of the sample container in the sample rack.
  • the container identification includes detection mode information, that is, the corresponding detection mode can be obtained through the container identification. Based on this, in this application, the identification of each sample container in the sample rack includes its own detection mode, so the detection mode of the detection position on the sample rack can no longer be pre-appointed.
  • the control device 30 is electrically connected to the second sample rack identification collector and the sample container identification collector. Specifically, the control device 30 may be connected to the second sample rack identification collector and the sample container identification collector through a cable.
  • the control device 30 is configured to determine the container identifier, the sample rack identifier, and the position of the sample container corresponding to each container identifier on the sample rack according to the sample rack identifier collected by the second sample rack identifier collector and the container identifier collected by the container identifier collector. Two correspondences, and send scheduling instructions to the transmission mechanism and the feeding mechanism according to the second correspondence, so that the sample rack is transferred to the analyzer corresponding to the detection mode contained in the container identification on the sample container in the sample rack.
  • the sample analysis system when the sample analysis system is working, it is specifically: when the sample rack enters the blood cell analyzer 10, the blood cell analyzer 10 uses its second sample rack to identify the collector and the sample container to identify the collector , Collect the sample rack identification on the sample rack and the sample container identification of the sample container, and send them to the control device 30.
  • the control device 30 performs a comparison between the sample rack and the sample container on the sample rack according to the received sample rack identification and sample container identification.
  • the second correspondence relationship is determined, and the second correspondence relationship is distributed to the transmission mechanism and the feeding mechanism, so that the transmission mechanism and the feeding mechanism can carry out targeted transportation of the sample rack.
  • the recognizer in the blood cell analyzer 10 can be used for recognition without pre-setting the detection position of the sample rack. This method can assist the transportation of the sample rack between the transmission channel and the detection channel. .
  • the second corresponding relationship of the sample rack can be used. Furthermore, in this embodiment of the present application, the control device 30 sends the second corresponding relationship to the CRP analyzer 20.
  • the CRP analyzer 20 is provided with a third sample rack identification collector for identifying the sample rack identification on the sample rack that is transferred to the corresponding detection channel, and the CRP analyzer 20 identifies the collector according to the second correspondence relationship and the third sample rack
  • the collected sample rack identification performs corresponding detection on the sample in the sample container located on the sample rack in the detection area and the detection mode is CRP mode.
  • Embodiment 4 since the detection position on the sample rack has a specific detection mode, once the operator places an error, a detection error may occur. For this reason, in this embodiment of the application, the detection position on the sample rack is no longer fixed The detection mode is set in the sample container identification. In this way, the analyzer only needs to identify the sample container identification to know whether the detection mode of the sample container corresponds to that of the analyzer, and if it corresponds directly Check, if it does not correspond, skip it. Therefore, the operator can freely place the sample container on the sample rack without paying attention to the placement position. Accordingly, the detection efficiency is also improved.
  • the CRP analyzer 20 in the sample analysis system provided in the embodiment of the present application may further include a closed sampling device and an open sampling device.
  • the closed sampling device is used to suck the sample transferred by the sample transfer device to the sample container on the sample rack in the corresponding detection channel.
  • the open sampling device is used to suck the sample manually transferred to the sample container in the detection area of the CRP analyzer.
  • the open sampling device is provided with an open space, so that the operator can manually transfer the sample container to the detection area of the CRP or remove the sample container from the detection area.
  • the sample rack containing the blood sample container is placed on the sample transfer device, and the sample transfer device drives the sample rack to the CRP analyzer 20, thereby automatically testing the blood.
  • the sample size is small, and the operator only needs to detect the C-reactive protein parameters in the sample separately. If the sample rack can only be placed on the sample transfer device at this time, and the sample rack is driven by the sample transfer device to move and transmit the sample rack to the CRP analyzer 20 for testing, it will be time-consuming and inefficient, especially the clinical emergency needs cannot be met.
  • the operator can manually transfer a single sample container, especially an emergency sample container, to the open sampling device for aspiration, so that the sample can be detected and analyzed quickly without waiting for the sample transfer device to transfer the sample.
  • the CRP analyzer 20 for the CRP analyzer 20, either a stand-alone CRP unit used only for detecting C-reactive protein in a sample, or a CRP unit that can be used for detecting C-reactive protein and blood cells in a sample at the same time CRP blood cell machine.
  • This application is not limited, and those skilled in the art can freely select the type of CRP analyzer 20 according to needs.
  • control device 30 may further include: at least one display (the control device in the figure is a calculator with a display) for receiving the CRP analyzer 20 and/or blood cell analysis The test result sent by the meter 10 is displayed.
  • control device 30 can obtain the test results and display them on the display after each test is done in the sample rack, and then after all the tests are completed, all test results are combined and then displayed on the display. On display.
  • the synthesis of multiple test results can be a simple combination, or the data display can be arranged and combined from different test results as needed.
  • control device 30 further includes: at least one data storage device for receiving and storing the detection result sent by the CRP analyzer 20 and/or the blood cell analyzer 10.
  • the stored test results are convenient for subsequent recall or reading of data.
  • the sample analysis system may further include: a loading platform 70 and a platform loading mechanism 71, wherein,
  • the loading platform 70 is located at one end of the transmission channel, and the loading platform 70 is used for placing the sample rack.
  • the loading platform 70 is located at the front end of the transmission direction X of the transmission channel, that is, the sample rack is first moved from the loading platform 70 to the transmission channel, and then is transported to each analyzer through the transmission channel.
  • the platform loading mechanism 71 is used to transfer the sample rack on the loading platform 70 to the transmission channel.
  • the sample analysis system further includes: a sample rack detector (not shown in the figure), wherein:
  • the sample rack detector is arranged on the loading platform 70 and is used to detect the sample rack on the loading platform 70. When the sample rack detector detects the sample rack on the loading platform 70, it sends a transfer signal.
  • the platform loading mechanism 71 is electrically connected to the sample rack detector. When the platform loading mechanism 71 receives the transfer signal, the platform loading mechanism 71 transfers the sample rack from the loading platform 70 to the transmission channel.
  • the sample analysis system further includes: an unloading platform 80 and a platform unloading mechanism 81, where:
  • the unloading platform 80 is arranged at the other end of the transmission channel, and the unloading platform 80 is used to place the unloading platform of the sample rack of the sample rack. Referring to the description in Embodiment 9 and FIG. 10, the unloading platform 80 is set at the end of the transmission direction X of the transmission channel. After the samples in the sample containers on the sample racks on the transmission channel are all tested, the sample racks are all transferred to the unloading platform 80 for storage.
  • the platform unloading mechanism 81 is used to transfer the sample rack in the transmission channel to the unloading platform 80.
  • the feeding mechanism in the sample analysis system further includes: a transmission mechanism 421, a loading buffer area 422, and a loading mechanism 423, wherein:
  • the transmission mechanism 421 can adopt any one or a combination of chain type mechanism, crawler type mechanism, belt type mechanism, roller type mechanism, and track type mechanism. If multiple combinations are used, the transmission mechanism 421 can be provided with multiple different styles. mechanism.
  • a detection channel is formed in the transmission mechanism 421. And the position of the detection channel corresponds to the position of the detection area of the analyzer corresponding to the feeding mechanism, so that the sample container transferred in the detection channel can be successfully detected.
  • the loading buffer area 422 is located between the detection channel and the transmission channel.
  • the loading buffer area 422 is mainly for consideration. If the transmission channel transfers a large number of sample racks to the analyzer, the analyzer completes each sample. The racks need to consume a certain amount of time. If all the sample racks on the transmission channel are transmitted to the analyzer, it will affect the normal analysis and detection. Setting the loading buffer area 422 can make the sample racks transferred on the transmission channel be buffered in this area first. Then, according to the detection speed of the analyzer, the sample racks buffered in the area are sequentially transferred to the detection channel.
  • the loading mechanism 423 is located below the loading buffer area 422, and is used to transfer the sample racks passing through the transmission channel to the loading buffer area 422, and to transfer the sample racks in the loading buffer area 422 to the detection channel.
  • the loading mechanism 423 may include: a bracket 131, a pushing claw 132, and a pushing claw driving device 133.
  • the bracket 131 is disposed between the transmission channel and the detection channel to support the loading mechanism 423.
  • the push claw 132 is arranged on the support 131, and is used to drive the sample rack stored in the loading buffer area to slide toward the detection channel or the transmission channel, thereby realizing the transmission of the sample rack between the transmission channel and the detection channel; the push claw driving device 133 is installed
  • the bracket 131 is used to drive the push claw 132 to perform the above-mentioned movement process.
  • the loading buffer area 422 in the sample analysis system of the embodiment of the present application includes: a panel 141, where the panel 141 is used to carry a sample rack, and a transmission is provided on the panel 141.
  • the channel extends to the long hole 142 of the detection channel.
  • the push claw driving device includes: a horizontal push assembly 1331, a push claw mounting seat 1332, and a lifting assembly 1333.
  • the horizontal push assembly 1331 is arranged on the bracket 131 and can move horizontally relative to the bracket 131; the push claw mounting seat 1332 is compatible with the horizontal push
  • the components 1331 are linked together, and the horizontal pushing component 1331 drives the push claw mounting seat 1332 to move horizontally between the detection channel and the transmission channel;
  • the lifting component 1333 is arranged on the pushing claw mounting seat 1332, and the pushing claw 132 is arranged on the lifting component 1333 to lift
  • the component 1333 drives the push pawl 132 to rise so that the push pawl 132 at least partially penetrates the elongated hole 142 on the panel 141 and is matched with the bottom of the sample holder.
  • the horizontal pushing component 1331 can drive the push pawl mounting seat 1332 to move horizontally, thereby causing The push claw 132 drives the sample holder to slide on the panel 141 toward the detection channel or the transmission channel.
  • a position sensor 135 is respectively provided at the two ends of the bracket 131 near the detection channel and the transmission channel.
  • the position sensor 135 can be connected to the push pawl mounting seat 1332 or the push pawl 132.
  • the cooperation enables the system controller to obtain the movement position of the push claw 132.
  • the position sensor 135 is preferably an optocoupler, and an optocoupler is provided on the push claw mounting seat 1332. When the push claw mounting seat 1332 moves close to the detection channel or the transmission channel, the optocoupler interacts with the optocoupler to cause the optocoupler to emit The sensing signal enables the system controller to determine the position of the push pawl 132.
  • the horizontal pushing component 1331 may be a motor timing belt drive structure, and the motor drives the timing belt to rotate, thereby driving the push claw mounting seat 1332 to perform horizontal movement.
  • the horizontal pushing component 1331 may also be a linear motor, and the primary driving push claw mounting seat 1332 of the linear motor performs horizontal linear motion.
  • a linear guide 134 can also be installed on the bracket 131, and the push claw mounting seat 1332 can be slidably mounted on the linear guide 134.
  • Lifting assembly 1333 can use lifting cylinders to fix the cylinder body of the lifting cylinder on the push claw mounting seat 1332, and fix the push claw 132 to the piston rod of the lifting cylinder, and control the piston rod of the lifting cylinder to drive the push claw 132 to move up and down. .
  • the bottom of the sample rack 15 is provided with bottom grooves 151 at intervals.
  • the push claw 132 extends upward from the elongated hole 142 on the panel 141, it can be inserted into the bottom groove 151 at the bottom of the sample rack 15 to drive the sample.
  • the frame 15 moves synchronously. It can be seen from the figure that there are multiple detection positions on the sample rack 15.
  • the analyzer Before the sample rack 15 shown in Figure 15 enters the analyzer for sampling and analysis, the analyzer needs to scan the barcode of the sample container on the sample rack 15 to obtain the detection mode of the corresponding sample. Therefore, the sample rack 15 corresponds to the side of each detection position.
  • the wall is provided with a scanning hole 153 to facilitate the identification collector to scan the container identification pasted on the sample container.
  • the feeding mechanism further includes: an unloading buffer area 424 and an unloading mechanism 425, wherein the unloading buffer area 424 is located between the detection channel and the transmission channel, and the unloading buffer area 424 and the loading buffer area 422 It is arranged at intervals along the transmission direction of the detection channel. As shown in FIG. 11, the loading buffer area 422 and the unloading buffer area 424 are respectively located at both ends of the detection channel; the unloading mechanism 425 is located in the unloading buffer area and is used to transfer the The sample rack is transferred to the unloading buffer area 424, and the sample rack in the unloading buffer area 424 is transferred to the transmission channel.
  • FIG. 12 is a schematic diagram of a twelfth embodiment provided by the sample analysis system of this application.
  • the sample analysis system includes: a blood cell analyzer 10, a CRP analyzer 20, a sample transfer device and a control device 30.
  • the function of the sample transfer device is to transfer the sample rack in which the sample container is placed.
  • the sample transfer device includes: a transmission mechanism 41 and at least two feeding mechanisms 42.
  • the CRP analyzer 20 and the blood cell analyzer 10 respectively correspond to a feeding mechanism, and the detection area of the CRP analyzer 20 and the blood cell analyzer 10 corresponds to the detection channel of the corresponding feeding mechanism 42. Therefore, the sample in the sample container on the sample rack can be subjected to CRP analysis in the CRP analyzer 20, or, in the blood cell analyzer 10, to perform routine blood analysis.
  • the CRP analyzer 20 is used to detect the C-reactive protein in the sample transferred by the sample transfer device to the sample container on the sample rack in the corresponding detection channel.
  • the blood cell analyzer 10 is used to detect blood cells transferred by the sample transfer device to the sample container on the sample rack in the corresponding detection channel.
  • the CRP analyzer 20 is located in front of the blood cell analyzer 10 in the transmission direction X along the transmission channel.
  • front and “rear” are relative concepts, where “front” refers to a position that passes first along the transmission direction, and “rear” refers to a position that passes backward along the transmission direction, and then the CRP analyzer 20 is located in front of the blood cell analyzer 10, that is, the sample rack on the transmission channel passes through the CRP analyzer 20 first, and then passes through the blood cell analyzer 10.
  • the transmission direction is from right to left
  • front refers to a position relatively to the right in the figure
  • “rear” refers to a position relatively to the left in the figure. Therefore, in this application, “ “Front” and “rear” describe the relative positional relationship between the blood cell analyzer 10 and the CRP analyzer 20, rather than a simple understanding of the literal meaning, and the literal meaning should not constitute a limitation to this application.
  • the control device 30 is electrically connected to the CRP analyzer 20, the blood cell analyzer 10, and the sample transfer device.
  • the control device 30 can be a desktop computer, a notebook computer, a single-chip computer, a PDA or other devices with computing capabilities.
  • the control device 30 is used to control the sample transfer device to transfer the sample container on the sample rack to any one of the CRP analyzer 20 and the blood cell analyzer 10 for testing, or to transfer to the CRP analyzer 20 and the blood cell analyzer 10 in turn for CRP Both the analyzer 20 and the blood cell analyzer 10 perform corresponding detection on the sample in the sample container.
  • the CRP analyzer 20 is located in front of the blood cell analyzer 10, and the blood cell analyzer 10 and CRP analyzer 20 each correspond to a feeding mechanism, and the detection area of the blood cell analyzer 10 and CRP analyzer 20 corresponds to the detection channel of the respective feeding mechanism, so that it is suitable for routine blood analysis and CRP detection.
  • the sample driven by the transmission mechanism, the sample rack with the sample container is placed on the transmission channel, first moves to the position of the CRP analyzer 20, and is transferred to the CRP analyzer 20 by the feeding mechanism corresponding to the CRP analyzer 20 Perform CRP analysis in the corresponding detection channel.
  • the sample analysis system may also include: one or two of a pusher staining machine and a saccharification instrument.
  • a pusher staining machine and a saccharification instrument For personnel, on the basis that the blood cell analyzer 10 is located in front of the CRP analyzer, how to set the position of the pusher dyeing machine and the saccharification apparatus is within the protection scope of this application, and is not limited to this application.
  • the pusher dyeing machine and the saccharification apparatus please refer to the relevant description in the above-mentioned embodiment 2 and embodiment 3.

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

L'invention concerne un système d'analyse d'échantillon comprenant un analyseur de CRP (20), un analyseur de cellules sanguines (10), un dispositif de transfert d'échantillon et un dispositif de commande (30). Le dispositif de transfert d'échantillon comprend un mécanisme de transmission (41) doté d'un canal de transmission et d'au moins deux mécanismes d'alimentation (42) comprenant des canaux d'analyse, les mécanismes d'alimentation (42) étant agencés à des intervalles le long de la direction de transmission du canal de transmission, l'analyseur de CRP (20) et l'analyseur de cellules sanguines (10) correspondant chacun à un mécanisme d'alimentation (42), et le long de la direction de transmission (X) du canal de transmission, l'analyseur de cellules sanguines (10) étant situé devant l'analyseur de CRP (20) ; le dispositif de commande (30) est électroniquement connecté à l'analyseur de CRP (20), à l'analyseur de cellules sanguines (10) et au dispositif de transfert d'échantillon, respectivement. Le système d'analyse d'échantillon peut commander au dispositif de transfert d'échantillon de transférer un récipient d'échantillon sur un cadre à échantillon à l'analyseur de CRP (20) et/ou à l'analyseur de cellules sanguines (10) en vue d'analyses, et peut améliorer considérablement l'efficacité d'analyses de sang courantes et d'analyse de la CRP.
PCT/CN2019/093884 2019-06-28 2019-06-28 Système d'analyse d'échantillon WO2020258310A1 (fr)

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CN113959992A (zh) * 2021-10-20 2022-01-21 深圳市科曼医疗设备有限公司 一种全血检测分析系统及全血样本检测方法
CN114755434A (zh) * 2022-06-13 2022-07-15 深圳市帝迈生物技术有限公司 样本分析系统及样本检测控制方法、装置、控制器和介质
CN114755433A (zh) * 2022-06-13 2022-07-15 深圳市帝迈生物技术有限公司 样本检测控制方法、系统及控制设备
CN114755436A (zh) * 2022-06-13 2022-07-15 深圳市帝迈生物技术有限公司 样本检测控制方法、系统及控制设备
CN117129689A (zh) * 2023-09-04 2023-11-28 中元汇吉生物技术股份有限公司 特定蛋白检测方法

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CN113959992A (zh) * 2021-10-20 2022-01-21 深圳市科曼医疗设备有限公司 一种全血检测分析系统及全血样本检测方法
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CN114755434A (zh) * 2022-06-13 2022-07-15 深圳市帝迈生物技术有限公司 样本分析系统及样本检测控制方法、装置、控制器和介质
CN114755433A (zh) * 2022-06-13 2022-07-15 深圳市帝迈生物技术有限公司 样本检测控制方法、系统及控制设备
CN114755436A (zh) * 2022-06-13 2022-07-15 深圳市帝迈生物技术有限公司 样本检测控制方法、系统及控制设备
CN114755434B (zh) * 2022-06-13 2022-10-21 深圳市帝迈生物技术有限公司 样本分析系统及样本检测控制方法、装置、控制器和介质
CN117129689A (zh) * 2023-09-04 2023-11-28 中元汇吉生物技术股份有限公司 特定蛋白检测方法

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