WO2020256287A3 - 베타-사이클로덱스트린을 통한 호스트-게스트 상호작용에 의해 온도감응성 폴리포스파젠에 결합된 생리활성 물질을 포함하는 하이드로젤 포접 복합체 및 이의 용도 - Google Patents

베타-사이클로덱스트린을 통한 호스트-게스트 상호작용에 의해 온도감응성 폴리포스파젠에 결합된 생리활성 물질을 포함하는 하이드로젤 포접 복합체 및 이의 용도 Download PDF

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Publication number
WO2020256287A3
WO2020256287A3 PCT/KR2020/006548 KR2020006548W WO2020256287A3 WO 2020256287 A3 WO2020256287 A3 WO 2020256287A3 KR 2020006548 W KR2020006548 W KR 2020006548W WO 2020256287 A3 WO2020256287 A3 WO 2020256287A3
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WIPO (PCT)
Prior art keywords
bioactive substance
host
temperature
polyphosphazene
cyclodextrin
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PCT/KR2020/006548
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English (en)
French (fr)
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WO2020256287A2 (ko
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송수창
홍기현
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한국과학기술연구원
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Priority to JP2021576096A priority Critical patent/JP7373702B2/ja
Priority to CN202080059215.4A priority patent/CN114269391A/zh
Priority to EP20826379.8A priority patent/EP3988580A4/en
Publication of WO2020256287A2 publication Critical patent/WO2020256287A2/ko
Publication of WO2020256287A3 publication Critical patent/WO2020256287A3/ko

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Abstract

본원은 복수의 소수성 아미노산, 친수성 고분자, 및 호스트 분자가 치환된 온도감응성 폴리포스파젠; 및 게스트 분자가 연결된 생리활성 물질을 포함하는, 하이드로젤 조성물로서, 상기 호스트 분자에 상기 게스트 분자가 호스트-게스트 상호작용(host-guest interaction)에 의하여 포접(inclusion)되어 상기 폴리포스파젠과 상기 생리활성 물질이 컨쥬게이트를 형성하는 것인, 하이드로젤 조성물에 관한 것이다. 본원의 하이드로젤 조성물이 생체 내에 투입될 경우 생리활성 물질을 서서히 방출하며 줄기세포 분화에 유리한 조건을 제공한다. 뿐만 아니라, 줄기세포의 특정 분화에 적합하도록 생리활성 물질의 종류, 비율 및 배열이 제어된 본원의 하이드로젤 조성물을 높은 재현성으로 제조될 수 있다.
PCT/KR2020/006548 2019-06-19 2020-05-19 베타-사이클로덱스트린을 통한 호스트-게스트 상호작용에 의해 온도감응성 폴리포스파젠에 결합된 생리활성 물질을 포함하는 하이드로젤 포접 복합체 및 이의 용도 WO2020256287A2 (ko)

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JP2021576096A JP7373702B2 (ja) 2019-06-19 2020-05-19 ベータ－シクロデキストリンを通じたホスト－ゲスト相互作用により感温性ポリホスファゼンに結合した生理活性物質を含むヒドロゲル包接複合体及びその使用
CN202080059215.4A CN114269391A (zh) 2019-06-19 2020-05-19 包含通过使用β-环糊精的主体-客体相互作用与热敏性聚(磷腈)结合的生理活性物质的水凝胶包合复合物及其用途
EP20826379.8A EP3988580A4 (en) 2019-06-19 2020-05-19 HYDROGEL INCLUSION COMPLEX CONTAINING A BIOACTIVE SUBSTANCE BOUND TO TEMPERATURE-SENSITIVE POLYPHOSPHAZENE BY HOST-GUEST INTERACTION USING BETA-CYCLODEXTRIN, AND USE THEREOF

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KR1020190073071A KR102286453B1 (ko) 2019-06-19 2019-06-19 베타-사이클로덱스트린을 통한 호스트-게스트 상호작용에 의해 온도감응성 폴리포스파젠에 결합된 생리활성 물질을 포함하는 하이드로젤 포접 복합체 및 이의 용도
KR10-2019-0073071 2019-06-19

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CN114773629B (zh) * 2022-05-20 2024-04-12 昆明理工大学 用于创伤性脑损伤的可注射光固化止血水凝胶的制备方法

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EP3988580A4 (en) 2023-12-06
US20210009763A1 (en) 2021-01-14
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WO2020256287A2 (ko) 2020-12-24
CN114269391A (zh) 2022-04-01

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