WO2020203143A1 - Puce d'échantillonnage de liquide - Google Patents

Puce d'échantillonnage de liquide Download PDF

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Publication number
WO2020203143A1
WO2020203143A1 PCT/JP2020/010829 JP2020010829W WO2020203143A1 WO 2020203143 A1 WO2020203143 A1 WO 2020203143A1 JP 2020010829 W JP2020010829 W JP 2020010829W WO 2020203143 A1 WO2020203143 A1 WO 2020203143A1
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WO
WIPO (PCT)
Prior art keywords
tip
liquid collection
liquid
male member
syringe
Prior art date
Application number
PCT/JP2020/010829
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English (en)
Japanese (ja)
Inventor
浮田純次
上原康賢
井藤尚継
中島知昭
瀧本和彦
Original Assignee
株式会社ジェイ・エム・エス
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社ジェイ・エム・エス filed Critical 株式会社ジェイ・エム・エス
Priority to JP2021511349A priority Critical patent/JP7484894B2/ja
Publication of WO2020203143A1 publication Critical patent/WO2020203143A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J15/00—Feeding-tubes for therapeutic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02—Access sites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub

Definitions

  • the present invention relates to a liquid collection tip that can be attached to and detached from the tip of a syringe (injector).
  • Enteral nutrition is known as a method of administering a liquid substance containing nutritional supplements and drugs to a patient who cannot eat food by mouth.
  • a catheter is placed in a patient with a catheter inserted from outside the body into the gastrointestinal tract (for example, stomach).
  • Known catheters include a nasal catheter inserted through the nose of a patient and a PEG (Percutaneous Endoscopic Gastrostomy) catheter inserted into a gastrostomy formed in the abdomen of a patient.
  • PEG Percutaneous Endoscopic Gastrostomy
  • a syringe injection method using a syringe as an injector is known as a method of administering a liquid substance to a patient.
  • the liquid material prepared in the wide-mouthed container is aspirated into the syringe, then the syringe is connected to the catheter and the liquid material in the syringe is injected into the patient via the catheter.
  • Patent Document 1 (particularly, see FIGS. 5A, 5B, and 6 of Patent Document 1) describes a male connector provided at the upstream end of the catheter and a syringe used in the syringe injection method.
  • the male connector has a male member and an outer cylinder that surrounds the male member.
  • the outer peripheral surface of the male member includes a tapered surface (so-called male tapered surface) whose outer diameter decreases as it approaches the tip.
  • a female screw is provided on the inner peripheral surface of the outer cylinder.
  • the tip of the syringe is a female connector that can be connected to this male connector.
  • the female connector (cylinder tip) has a hollow cylindrical portion.
  • the inner peripheral surface of the tubular portion is a tapered surface (so-called female tapered surface) whose inner diameter increases as it approaches the tip.
  • Male screws are provided on the outer peripheral surface of the tubular portion. The tapered surface of the male connector and the tapered surface of the female connector are fitted, and the female screw of the male connector and the male screw of the female connector are screwed together.
  • the syringe injection method has the following problems.
  • the tip of the cylinder provided on the syringe is very short. Therefore, it is difficult to immerse only the tip of the cylinder in the liquid material in the container and suck the liquid material. It can often happen that not only the tip of the cylinder but also the barrel is immersed in the liquid material.
  • the tip of the cylinder when the tip of the cylinder is immersed in a liquid material, the liquid material adheres to the outer peripheral surface of the cylinder tip and the male screws provided on the outer peripheral surface. It is troublesome to wipe off the liquid matter adhering to the male screw (particularly the valley), and it is difficult to completely wipe off the liquid matter.
  • the tip of the cylinder with the liquid material attached to the outer peripheral surface (or male screw) is connected to the male connector of the catheter, the liquid material is transferred to the female screw provided on the male connector.
  • the liquid material adhering to the male connector causes the male connector to become unsanitary.
  • the solidified liquid that has dried on the male connector firmly adheres to the male connector and prevents the male connector from being reconnected to the cylinder tip.
  • Patent Document 2 describes a syringe in which a tubular wetted portion is provided at the barrel tip of the barrel via a broken portion.
  • the cylinder tip is the same female connector as the female connector of Patent Document 1.
  • the liquid substance can be easily sucked, and the liquid substance does not adhere to the outer peripheral surface of the cylinder tip.
  • the first object of the present invention is to facilitate the work of sucking a liquid substance into a syringe.
  • a second object of the present invention is to prevent liquid matter from adhering to the outer peripheral surface of the cylinder tip of the syringe.
  • a third object of the present invention is to prevent liquid matter from overflowing from the cylinder tip when the male connector is connected to the cylinder tip of the syringe.
  • a fourth object of the present invention is to make it possible to perform a syringe injection method at low cost using an existing syringe.
  • the liquid collection tip of the present invention can be attached to and detached from the barrel tip of the syringe.
  • the liquid collection tip is such that the male member provided at one end of the liquid collection chip, the nozzle provided at the other end of the liquid collection chip, and the male member and the nozzle communicate with each other.
  • a flow path that penetrates the liquid collection tip along the longitudinal direction of the tip and a grip portion for gripping the liquid collection tip are provided.
  • the outer peripheral surface of the male member includes a tapered surface whose outer diameter decreases as it approaches the tip so as to fit into the cylinder tip of the syringe.
  • the grip portion includes an arm portion that protrudes in the same direction as the nozzle while being separated from the nozzle in the radial direction.
  • the present invention has the following effects. First, the work of sucking the liquid material into the syringe can be facilitated. Secondly, it is possible to prevent the liquid substance from adhering to the outer peripheral surface of the cylinder tip of the syringe. Thirdly, when the male connector is connected to the cylinder tip of the syringe, it is possible to prevent the liquid material from overflowing from the cylinder tip. Fourth, the syringe injection method can be performed at low cost using an existing syringe. Fifth, the liquid collection tip can be attached to and detached from the syringe without touching the male member or the nozzle. Sixth, the liquid collection tip can be left in a state where the grip portion is hooked on the edge of the wide-mouthed container with the nozzle facing downward.
  • FIG. 1A is a perspective view of the liquid sampling tip according to the first embodiment of the present invention as viewed from the male member side.
  • FIG. 1B is a perspective view of the liquid sampling tip according to the first embodiment of the present invention as viewed from the nozzle side.
  • FIG. 2 is a cross-sectional view of the liquid sampling tip according to the first embodiment of the present invention.
  • FIG. 3A is a perspective view of an example of a syringe used in the syringe injection method.
  • FIG. 3B is a cross-sectional view of the syringe of FIG. 3A.
  • FIG. 4A is a perspective view of the liquid collection tip of the first embodiment mounted on the syringe.
  • FIG. 4B is a cross-sectional view of FIG. 4A.
  • FIG. 5A is a perspective view of a male connector provided at the upstream end of a catheter placed in a patient.
  • FIG. 5B is a cross-sectional view taken along the line including the 5B-5B line of the male connector of FIG. 5A.
  • FIG. 6A is a perspective view showing a state in which the syringe is connected to the male connector.
  • FIG. 6B is a cross-sectional view of FIG. 6A.
  • FIG. 7A is an enlarged cross-sectional view of a portion 7A of FIG. 4B.
  • FIG. 7B is an enlarged cross-sectional view of the tip of the syringe and its vicinity.
  • FIG. 8A is a perspective view showing a state in which the liquid sampling tip of the first embodiment of the present invention is hooked on the edge of the wide-mouthed container.
  • FIG. 8B is a cross-sectional view of FIG. 8A.
  • FIG. 9A is a perspective view of the liquid sampling tip according to the second embodiment of the present invention as viewed from the male member side.
  • FIG. 9B is a perspective view of the liquid sampling tip according to the second embodiment of the present invention as viewed from the nozzle side.
  • FIG. 10 is a cross-sectional view of the liquid sampling tip according to the second embodiment of the present invention.
  • FIG. 11 is a cross-sectional view of the liquid sampling tip according to the third embodiment of the present invention.
  • the grip portion may further include an extension portion extending outward in the radial direction.
  • the arm portion may be provided in the expansion portion. According to such an embodiment, the liquid collection tip can be stably gripped by the gripping portion.
  • the liquid collection tip may be twice symmetrical with respect to the axis of the liquid collection tip. According to such an embodiment, the liquid collection tip can be easily and stably gripped by the gripping portion.
  • the liquid sampling tip of the present invention may further include an outer cylinder that is separated from the male member and surrounds the male member. Such an embodiment is advantageous for keeping the male member clean.
  • the liquid sampling tip of the present invention does not have to be provided with a female screw to be screwed into the male screw provided at the tip of the cylinder.
  • Such an embodiment allows the liquid collection tip to be slip-connected to the syringe. This is advantageous for easily and quickly attaching and detaching the liquid collection tip to and from the syringe.
  • the arm portion may be the first arm portion.
  • the grip portion may further include a second arm portion that protrudes in the same direction as the male member while being separated from the male member in the radial direction.
  • the first arm portion and the second arm portion may be continuous along the longitudinal direction of the liquid collection tip. According to such an embodiment, the liquid collection tip can be gripped more stably by the gripping portion.
  • a flare shape may be provided on the inner surface of the male member that defines the flow path so that the inner diameter of the flow path increases toward the tip of the male member.
  • FIG. 1A is a perspective view of the liquid sampling tip 1 according to the first embodiment of the present invention as viewed from the male member 10 side.
  • FIG. 1B is a perspective view of the liquid collection tip 1 as viewed from the nozzle 20 side.
  • FIG. 2 is a cross-sectional view of the liquid sampling tip 1.
  • the liquid collection tip 1 is provided with a male member 10 at one end and a nozzle 20 at the other end.
  • the male member 10 and the nozzle 20 are arranged coaxially.
  • the side of the male member 10 is referred to as the "upper" side of the liquid sampling tip 1
  • the side of the nozzle 20 is referred to as the "lower" side of the liquid sampling tip 1.
  • the direction along the axis that is, the axis of the liquid collection tip 1) 1a (see FIG. 2) common to the male member 10 and the nozzle 20 is referred to as the "longitudinal direction" of the liquid collection tip 1.
  • the direction along the straight line orthogonal to the axis 1a of the liquid collection tip 1 is referred to as the "radial direction”.
  • the side closer to the axis 1a is called the “inner” side
  • the side far from the axis 1a is called the “outer” side.
  • the liquid collection tip 1 is twice symmetrical with respect to its axis 1a (that is, when the liquid collection tip 1 is rotated 180 degrees around the axis 1a, it overlaps with the original shape).
  • the male member 10 has a hollow tubular shape.
  • the outer peripheral surface 12 of the male member 10 is a tapered surface (so-called male tapered surface) whose outer diameter decreases as it approaches the tip of the male member 10.
  • the outer cylinder 15 surrounds the male member 10.
  • the outer cylinder 15 has a hollow substantially cylindrical shape coaxial with the male member 10.
  • the outer cylinder 15 faces the tapered surface 12 of the male member 10 and is separated from the male member 10 (particularly the tapered surface 12) in the radial direction.
  • the male member 10 and the outer cylinder 15 are connected via a bottom plate 14 that projects in a flange shape along the radial direction from the base end of the male member 10.
  • the male member 10 (particularly the tapered surface 12) may have the same configuration as the male member of the male connector of Patent Document 1 described above used in enteral nutrition.
  • the tapered surface 12 has the same outer diameter and taper angle as the tapered surface 912 provided on the male member 910 of the male connector 900 (see FIGS. 5A and 5B) described later.
  • the inner peripheral surface 15a of the outer cylinder 15 is a cylindrical surface coaxial with the male member 10, and its inner diameter is the same as or the valley diameter of the female screw 916 formed on the inner peripheral surface of the outer cylinder 915 of the male connector 900. Greater.
  • the male member 10 and the outer cylinder 15 may be the same as the outer cylinder 915 in which the male member 910 and the female screw 916 of the male connector 900 are omitted.
  • the nozzle 20 has an elongated hollow tubular shape.
  • the outer peripheral surface 22 of the nozzle 20 is a tapered surface (male tapered surface) whose outer diameter decreases as it approaches the tip of the nozzle 20.
  • the shape of the outer peripheral surface 22 is not limited to this, and may be, for example, a cylindrical surface having a constant outer diameter in the longitudinal direction thereof.
  • the flow path 17 penetrates the liquid collection tip 1 along the axis 1a of the liquid collection tip 1 (that is, the longitudinal direction of the liquid collection tip 1), and the tip of the male member 10 and the tip of the male member 10 Each is opened at the tip of the nozzle 20.
  • the male member 10 and the nozzle 20 communicate with each other via the flow path 17.
  • a pair of grips 30 project outward from the outer cylinder 15 in the radial direction.
  • the grip portion 30 includes an expansion portion 33 extending outward in the radial direction and an arm portion 31 extending from the tip end (outer end) of the expansion portion 33 toward the same side as the nozzle 20 (that is, downward).
  • the expansion portion 33 extends substantially along the radial direction, and the arm portion 31 extends substantially parallel to the longitudinal direction of the liquid collection tip 1.
  • the expansion portion 33 and the arm portion 31 are connected at a substantially right angle, and when viewed along the direction perpendicular to the longitudinal direction of the liquid collection tip 1, the grip portion 30 as a whole has a substantially “L” shape (or hook shape). have.
  • the arm portion 31 is separated from the nozzle 20 in the radial direction and projects downward.
  • the outer surface of the arm portion 31 (the surface facing the side opposite to the male member 10 and the nozzle 20) is a flat surface substantially perpendicular to the radial direction, and constitutes the grip surface 30a of the grip portion 30.
  • the material of the liquid sampling tip 1 is not limited, but is preferably a material having shape retention, and further, a hard material (hard material) having mechanical strength (rigidity) that is not substantially deformed by an external force. It is preferable to have.
  • resin materials such as polypropylene (PP), polycarbonate (PC), polyacetal (POM), polystyrene, polyamide, polyethylene, hard polyvinyl chloride, and acrylonitrile-butadiene-styrene copolymer (ABS) can be used, among others.
  • Polypropylene (PP), polyethylene, polycarbonate (PC) and acrylonitrile-butadiene-styrene copolymer (ABS) are preferred.
  • the liquid sampling chip 1 can be integrally manufactured as a single component by an injection molding method or the like using the above resin material.
  • the liquid collection tip 1 is used when enteral nutrition is performed by the syringe injection method.
  • An example of a syringe used in the syringe injection method is shown in FIGS. 3A and 3B.
  • the syringe 60 includes a barrel (outer cylinder) 61 and a plunger 68.
  • the barrel 61 has a hollow cylindrical shape, one end (upper end) is open, and the other end (lower end) is provided with a cylinder tip (nozzle) 63.
  • a plunger 68 is inserted into the opening at the upper end of the barrel 61 so that it can be inserted and removed.
  • the cylinder tip 63 has the same configuration as the female connector of Patent Document 1 described above used in the syringe injection method.
  • the tubular tip 63 has a cylindrical tubular portion (messuler) 70.
  • the inner peripheral surface 72 of the tubular portion 70 is a tapered surface (female tapered surface) whose inner diameter increases as it approaches the tip of the tubular portion 70.
  • a male screw (screw protrusion) 76 is provided on the outer peripheral surface of the tubular portion 70.
  • a small diameter portion 65 having an inner diameter smaller than these is formed between the liquid storage portion 62 of the barrel 61 and the cylinder tip 63.
  • the liquid storage unit 62 is a portion of the barrel 61 into which the plunger 68 is inserted and removed, and is a portion capable of storing a liquid substance.
  • the small diameter portion 65 prevents the plunger 68 inserted in the liquid storage portion 62 from entering the cylinder tip 63.
  • a gasket 69 is attached to the tip of the plunger 68. The gasket 69 slides on the inner peripheral surface of the barrel 61 along the longitudinal direction of the barrel 61 while forming a liquid-tight seal with the inner peripheral surface of the barrel 61.
  • the syringe injection method using the liquid collection tip 1 and the syringe 60 is roughly performed as follows.
  • the liquid may contain an enteric nutrient and a thickener.
  • the liquid may contain an enteric nutrient and a thickener.
  • the liquid collection tip 1 is attached to the tip 63 of the syringe 60.
  • the operator can grasp the liquid collection tip 1 with one hand with his / her finger on the grip portion 30 (grip surface 30a), grasp the barrel 61 with the other hand, and attach the liquid collection tip 1 to the syringe 60. ..
  • FIG. 7A shows an enlarged portion 7A of FIG. 4B.
  • the male member 10 of the liquid collection tip 1 is inserted into the cylinder tip 63 (tubular portion 70) of the syringe 60.
  • the cylinder tip 63 is inserted into the gap between the male member 10 of the liquid collection tip 1 and the outer cylinder 15.
  • the tapered surface 12 of the male member 10 see FIGS. 1A and 2) and the tapered surface 72 of the cylinder tip 63 (see FIGS. 3A and 3B) have the same diameter and taper angle. Therefore, the tapered surface 12 and the tapered surface 72 are in close contact with each other, and the male member 10 and the cylinder tip 63 are liquid-tightly connected.
  • the flow path 17 of the liquid collection tip 1 and the liquid storage portion 62 of the syringe 60 communicate with each other.
  • the tip of the nozzle 20 is immersed in the liquid material in the wide-mouthed container.
  • the plunger 68 is operated to suck the liquid material into the barrel 61.
  • the liquid collection tip 1 is removed from the syringe 60.
  • the operator can remove the liquid collection tip 1 from the syringe 60 by pinching the liquid collection tip 1 with a finger on the grip portion 30 (grip surface 30a) with one hand and grasping the barrel 61 with the other hand.
  • the liquid collection tip 1 is connected to another empty syringe 60, and the liquid material is sucked into the syringe 60 via the liquid collection tip 1 in the same manner as described above.
  • the liquid collection tip 1 is sequentially replaced with a new syringe 60, and all the syringes 60 are filled with the liquid material.
  • FIG. 5A is a perspective view of a male connector 900 provided at the upstream end of a catheter (nasal catheter in this example) 950.
  • FIG. 5B is a cross-sectional view taken along the plane including the 5B-5B line of the male connector 900 of FIG. 5A.
  • the male connector 900 includes a connector main body 901 to which the syringe 60 is connected on one side, and a proximal end 902 to which the upstream end of the catheter 950 is connected on the other side.
  • the connector main body 901 has a male member 910 and an outer cylinder 915.
  • the male member 910 has a hollow tubular shape in which the flow path 917 is formed.
  • the outer peripheral surface 912 of the male member 910 is a tapered surface (so-called male tapered surface) whose outer diameter decreases as it approaches the tip of the male member 910.
  • the outer cylinder 915 has a hollow cylindrical shape and surrounds the male member 910 coaxially with the male member 910.
  • a female screw 916 is formed on the inner peripheral surface of the outer cylinder 915 (the surface facing the male member 910).
  • the connector main body 901 is the same as the male connector of Patent Document 1 described above used for enteral nutrition.
  • the base end portion 902 has a hollow tubular shape and is arranged coaxially with the male member 910.
  • the upstream end of the flexible catheter 950 is inserted and fixed in the proximal end 902.
  • the male member 910 and the catheter 950 are communicated with each other via the flow path 917.
  • the catheter 950 is inserted into the patient through the patient's nose and its downstream end (not shown) reaches the patient's stomach.
  • the material of the male connector 900 is not limited, but is preferably a hard material (hard material) having mechanical strength (rigidity) that is not substantially deformed by an external force.
  • hard material hard material
  • resin materials such as polypropylene (PP), acrylonitrile-butadiene-styrene copolymer (ABS), polycarbonate (PC), polyacetal (POM), polystyrene, polyamide, polyethylene, and hard polyvinyl chloride can be used.
  • PP polypropylene
  • ABS acrylonitrile-butadiene-styrene copolymer
  • PC polycarbonate
  • POM polyacetal
  • polystyrene polyamide
  • polyethylene polyethylene
  • hard polyvinyl chloride hard polyvinyl chloride
  • the tube tip 63 of the syringe 60 is connected to the connector main body 901 of the male connector 900.
  • the male member 910 of the male connector 900 is inserted into the tubular tip 63 (tubular portion 70) of the syringe 60, and the male screw 76 of the syringe 60 is screwed into the female screw 916 of the male connector 900.
  • the tapered surface 912 of the male member 910 (see FIGS. 5A and 5B) and the tapered surface 72 of the cylinder tip 63 (see FIGS. 3A and 3B) have the same diameter and taper angle.
  • the tapered surface 912 and the tapered surface 72 are in close contact with each other, and the male member 910 and the cylinder tip 63 are liquid-tightly connected.
  • the female screw 916 and the male screw 76 that are screwed together form a locking mechanism for locking the connection state between the male connector 900 and the syringe 60.
  • the connection method using screws is generally called "screw lock connection”.
  • the liquid storage portion 62 of the syringe 60, the flow path 917 of the male connector 900, and the catheter 950 communicate in this order.
  • the plunger 68 is operated to administer the liquid substance in the syringe 60 to the patient via the male connector 900 and the catheter 950. ..
  • the syringe 60 is separated from the male connector 900, another syringe 60 filled with a liquid substance is connected to the male connector 900, and the liquid substance in the syringe 60 is administered to the patient in the same manner as described above.
  • the syringes 60 are sequentially replaced, and the liquid matter in all the syringes 60 is administered to the patient.
  • the liquid collection tip 1 of the first embodiment is connected to the cylinder tip 63 of the syringe 60 when the liquid material is sucked into the syringe 60 (see FIGS. 4A and 4B).
  • the liquid collection tip 1 includes an elongated nozzle 20.
  • the liquid material in the wide-mouthed container is sucked into the syringe 60, only the tip of the nozzle 20 and its vicinity are immersed in the liquid material.
  • the cylinder tip 63 see FIG. 3A
  • the barrel 61 will also be immersed in the liquid material. It is extremely difficult to immerse only the short tube tip 63 in the liquid material and suck the liquid material into the syringe 60.
  • the nozzle 20 since the nozzle 20 is long, even if the liquid sampling tip 1 is displaced up and down when the plunger 68 is operated to suck the liquid material, the grip portion 30 and the barrel 61 are erroneously misplaced. It will not be immersed in liquid matter. By using the liquid collection tip 1, even an unskilled person can easily suck the liquid material into the syringe 60.
  • the liquid collection tip 1 includes a male member 10 that can be fitted into the cylinder tip 63 (tubular portion 70) of the syringe 60.
  • the male member 10 includes a tapered surface 12.
  • the tapered surface 12 is preferably the same as the tapered surface 912 provided on the male member 910 of the male connector 900 used in enteral nutrition. Therefore, the tapered surface 12 of the male member 10 is liquidtightly connected to the tapered surface 72 of the cylinder tip 63 of the syringe 60 (see FIG. 7A).
  • the liquid material flowing through the flow path 17 does not leak to the outside world through between the male member 10 and the cylinder tip 63.
  • the liquid material does not adhere to the outer peripheral surface (including the male screw 76) of the cylinder tip 63.
  • the outer peripheral surface of the cylinder tip 63 or A liquid substance adheres to the male screw 76. Therefore, after that, before connecting the cylinder tip 63 to the male connector 900, it is necessary to wipe off the liquid matter adhering to the outer peripheral surface (including the male screw 76) of the cylinder tip 63.
  • the liquid material is transferred to the female screw 916 of the male connector 900.
  • the cylinder tip 63 when the cylinder tip 63 is immersed in the liquid material and the liquid material is sucked into the syringe 60 without using the liquid collection tip 1, the cylinder tip 63 (tubular) is as shown in FIG. 7B. A liquid substance (a large number of dots are attached in FIG. 7B) is filled in the portion 70) up to the tip thereof.
  • the male connector 900 When the male connector 900 is connected to the cylinder tip 63 in this state (see FIG. 6B), the male member 910 pushes the liquid material in the cylinder tip 63 out of the cylinder tip 63. The liquid material overflows from the cylinder tip 63 and adheres to the female screw 916 of the male connector 900.
  • the liquid collection tip 1 of the first embodiment can be repeatedly connected to and separated from the syringe 60 having a female connector provided on the cylinder tip 63.
  • the syringe 60 is a general-purpose product generally used for performing the syringe injection method. In order to carry out the first embodiment, it is not necessary to make any design change to the existing syringe 60. Even when the syringe injection method is performed using a plurality of syringes 60, one liquid collection tip 1 may be sequentially replaced with the plurality of syringes 60. Unlike the syringe of Patent Document 2, the syringe 60 can be reused in the first embodiment. Therefore, in the first embodiment, the syringe injection method can be performed at low cost using the existing syringe 60.
  • the liquid collection tip 1 does not have the female screw 916 (see FIGS. 5A and 5B) provided in the male connector 900.
  • the liquid collection tip 1 and the syringe 60 are connected by taper fitting of the male member 10 and the cylinder tip 63 (see FIG. 7A). This connection method is generally called "slip connection".
  • the liquid collection tip 1 can be attached to and detached from the syringe 60 more easily and quickly than the male connector 900 can be attached to and detached from the syringe 60.
  • the slip connection has a lower connection strength than the screw lock connection, but the liquid collection tip 1 is connected to the syringe 60 only when the liquid material is sucked into the syringe 60.
  • the connection between the liquid collection tip 1 and the syringe 60 is a slip connection having a relatively low connection strength. There is virtually no inconvenience.
  • the liquid collection tip 1 includes a pair of grip portions 30.
  • the liquid collection tip 1 is twice symmetrical with respect to the axis 1a. Therefore, the pair of grips 30 are arranged symmetrically with respect to the shaft 1a.
  • the grip portion 30 (grip surface 30a) can be easily and stably gripped in the direction orthogonal to the axis 1a with two fingers (for example, the thumb and the index finger) of one hand. In this way, the liquid collection tip 1 can be gripped by the grip portion 30 to attach / detach the liquid collection tip 1 to / from the syringe 60. It is unlikely that a finger touches the male member 10 or the nozzle 20 when the liquid sampling tip 1 is attached or detached.
  • the male member 10 and the nozzle 20 are less likely to be contaminated. Secondly, when the liquid collection tip 1 is removed from the syringe 60, it is unlikely that the finger touches the liquid matter adhering to the liquid collection tip 1 and the finger becomes dirty.
  • the expansion portion 33 constituting the grip portion 30 extends along the radial direction.
  • the direction of the force applied by the finger to the grip surface 30a substantially coincides with the direction of the grip portion 30. Therefore, it is unlikely that the gripping surface 30a is tilted due to the bending moment applied to the expansion portion 33. This is advantageous for stably gripping the liquid collection tip 1.
  • the grip portion 30 includes an arm portion 31 that protrudes downward while being separated from the nozzle 20 in the radial direction (see FIGS. 1A, 1B, and 2). Therefore, as shown in FIGS. 8A and 8B, the liquid collection tip 1 can be left in a state where the nozzle 20 is directed downward and the grip portion 30 is hooked on the edge 81 of the wide-mouth container 80. For example, the liquid collection tip 1 before being connected to the syringe 60 may be hooked on the wide-mouthed container 80 as shown in FIGS. 8A and 8B. This is advantageous for ensuring the cleanliness of the liquid collection chip 1 as compared with the case where the liquid collection chip 1 is placed on an unsanitary table or the like.
  • the used liquid collection tip 1 after filling the syringe 60 with the liquid material may be hooked on the wide-mouthed container 80 in which the liquid material is prepared as shown in FIGS. 8A and 8B. Unlike FIGS. 8A and 8B, if the used liquid collection chip 1 is left on the table, the liquid material remaining on the liquid collection chip 1 flows out and stains the table. In FIGS. 8A and 8B, this can be prevented.
  • the liquid collection tip 1 is arranged inside the wide-mouthed container 80, and the tip of the nozzle 20 is in contact with the inner surface 82 of the wide-mouthed container 80.
  • the outer cylinder 15 surrounds the male member 10. Therefore, it is unlikely that the operator's finger or the like touches the male member 10 (for example, its tapered surface 12) when handling the liquid collecting tip 1.
  • the male connector 900 may be contaminated via the tube tip 63 of the syringe 60, and eventually the patient may cause an infectious disease.
  • the outer cylinder 15 is advantageous for keeping the male member 10 clean and preventing such a situation from occurring.
  • outer cylinder 15 may be omitted as in the second embodiment described later.
  • FIG. 9A is a perspective view of the liquid sampling tip 2 according to the second embodiment of the present invention as viewed from the male member 10 side.
  • FIG. 9B is a perspective view of the liquid sampling tip 2 as viewed from the nozzle 20 side.
  • FIG. 10 is a cross-sectional view of the liquid sampling tip 2.
  • the grip portion 230 of the liquid collection tip 2 has an expansion portion 233 extending outward in the radial direction and a first extending portion 233 extending outward from the tip (outer end) of the expansion portion 233 toward the same side as the nozzle 20 (that is, downward).
  • An arm portion 231 and a second arm portion 232 extending from the tip end (outer end) of the expansion portion 233 toward the same side as the male member 10 (that is, upward) are provided.
  • the expansion portion 233 extends substantially along the radial direction, and the arm portions 231 and 232 extend substantially parallel to the longitudinal direction of the liquid collection tip 2.
  • the first arm portion 231 and the second arm portion 232 are smoothly continuous along the longitudinal direction of the liquid collection tip 2.
  • the grip portion 230 can also be said to have a second arm portion 232 added to the grip portion 30 of the first embodiment.
  • the expansion portion 233 and the arm portions 231 and 232 are connected at substantially right angles, and when viewed along the direction perpendicular to the longitudinal direction of the liquid collection tip 2, the grip portion 230 has a substantially "T" shape as a whole. ing.
  • the first arm portion 231 is separated from the nozzle 20 in the radial direction and projects downward.
  • the second arm portion 232 is separated from the male member 10 in the radial direction and projects upward.
  • the outer surface of the first arm portion 231 and the outer surface of the second arm portion 232 are flat surfaces substantially perpendicular to each other in the radial direction, and these continuously form the grip surface 230a of the grip portion 230.
  • the liquid collection tip 2 is also used when the enteral nutrition method is performed by the syringe injection method.
  • the liquid collection tip 2 can be gripped by the grip portion 230 (grip surface 230a) with a finger to attach and detach the liquid collection tip 2 to and from the syringe 60.
  • the downward protrusion length of the first arm 231 and the upward protrusion length of the second arm portion 232 are substantially the same.
  • the point of action of the force applied by the finger to the gripping surface 230a substantially coincides with the position of the expansion portion 233 in the vertical direction. Therefore, it is unlikely that the gripping surface 230a is tilted due to the bending moment applied to the expansion portion 233.
  • the grip portion 230 of the second embodiment is advantageous for stably gripping the liquid collection tip 2.
  • the outer cylinder 15 (see FIGS. 1A, 1B, and 2) provided in the liquid sampling tip 1 of the first embodiment is not provided.
  • the expansion portion 233 protrudes outward in the radial direction from a position between the male member 10 and the nozzle 20 (or the base end of the male member 10 or the base end of the nozzle 20).
  • the second arm portion 232 faces the male member 10 in the radial direction, even if the outer cylinder 15 is not provided, the operator's finger or the like is male when handling the liquid sampling tip 2.
  • the possibility of touching the member 10 (for example, its tapered surface 12) is low. Therefore, it is possible to ensure the cleanliness of the male member 10.
  • the liquid sampling tip 2 may be provided with an outer cylinder that surrounds the male member 10, similar to the outer cylinder 15 of the first embodiment.
  • the outer cylinder may be provided, for example, on the upper surface of the expansion portion 233 (the surface facing the same side as the male member 10) so as to project upward.
  • the outer cylinder 15 may be provided as in the first embodiment, and the expansion portion 233 may be provided in the outer cylinder 15.
  • the second embodiment is the same as the first embodiment except for the above.
  • the description of the first embodiment applies to the second embodiment.
  • FIG. 11 is a cross-sectional view of the liquid sampling tip 3 according to the third embodiment of the present invention.
  • a flare shape (or female tapered surface or conical surface) 18 is provided on the inner surface defining the flow path 17 in the male member 10 so that the inner diameter of the flow path 17 increases toward the tip of the male member 10.
  • the flare shape 18 extends from the tip of the male member 10 to a region having a predetermined length (preferably a region equal to or less than the length of the male member 10) in the longitudinal direction of the liquid collection tip 3.
  • the flare shape 18 has the following advantages.
  • the moldability is improved. That is, since the flare shape 18 reduces the thickness of the male member 10 in the radial direction, the molding accuracy of the tapered surface 12 of the male member 10 is improved. Further, the flare shape 18 improves the mold removal property of the liquid sampling tip 3 from the mold.
  • the connectivity to a syringe having a double-cylinder-structured cylinder tip is improved. It is known to perform the syringe injection method using a syringe having a cylinder tip having a double cylinder structure (see, for example, Patent Document 3). Although not shown, the tip of the double-cylinder structure is arranged so as to be surrounded by the tubular portion 70 coaxially with the tubular portion 70, in addition to the tubular portion 70 as an outer cylinder (see FIG. 3B). Further provided with a tubular portion as a cylinder. The tip of the double-cylinder structure is removable from the male connector 900. The liquid collection tip 3 can also be attached to and detached from the tip of the double cylinder structure.
  • the male member 10 When the liquid collection tip 3 is connected to this tubular tip, the male member 10 is inserted between the tubular portion (outer cylinder) and the tubular portion (inner cylinder) of the tubular tip, and the tubular portion (inner cylinder) is the male member 10. Will be inserted into.
  • the flare shape 18 guides the tubular portion into the male member 10. Therefore, the liquid collection tip 3 can be easily connected to the tip of the cylinder having a double cylinder structure.
  • the flare shape 18 may be configured so that a liquid-tight seal is formed between the flare shape 18 and the outer peripheral surface of the tubular portion.
  • the inner diameter (opening diameter) D of the flow path 17 (or flare shape 18) at the tip of the male member 10 is 2.45 mm or more, and further 2.85 mm or more. Is preferable.
  • the upper limit of the inner diameter D is not limited, but is preferably 4.027 mm or less from the viewpoint of preventing unintended erroneous connection with the female connector.
  • the third embodiment is the same as the first embodiment except for the above.
  • the description of the first embodiment applies to the third embodiment.
  • the liquid collection tip 3 of the third embodiment can also be attached to and detached from the cylinder tip 63 (see FIGS. 3A and 3B) of the syringe 60.
  • the tapered surface 12 and the tapered surface 72 are in close contact with each other, and the male member 910 and the cylinder tip 63 are liquid-tightly connected.
  • the flare shape 18 of the third embodiment may be provided on the liquid collection tip 2 of the second embodiment.
  • the shape of the grip portion is not limited to the first to third embodiments, and can be changed as appropriate.
  • the extension portion does not have to extend along the radial direction, and may be inclined toward the lower side (nozzle 20 side) or the upper side (male member 10 side) as the distance from the axis 1a of the liquid collection tip increases. ..
  • the arm portion does not have to extend parallel to the longitudinal direction of the liquid collection tip, and may be inclined outward in the radial direction or inward in the radial direction as the distance from the expansion portion increases.
  • the extension portion and the arm portion do not need to be connected at a substantially right angle, and may be smoothly connected in an arc shape so that they cannot be clearly distinguished, for example. Ribs extending from the extension to the arm may be provided to reinforce the grip.
  • the expansion portion constituting the grip portion may be separated downward from the outer cylinder 15.
  • a plurality of arms may share an extension.
  • a plurality of arm portions may protrude from a single grip portion that is a disk or a cylinder (or a cylinder) coaxial with the shaft 1a.
  • the grip portion is used for gripping the liquid collection tip in the radial direction, it is preferable to provide at least a pair of grip portions.
  • the liquid collection tip of the present invention may have two pairs of grips in a substantially cross shape when viewed along the longitudinal direction of the liquid collection tip.
  • the liquid collection tip of the present invention may include a female screw that is screwed into a male screw (screw protrusion) 76 provided on the cylinder tip 63 of the syringe 60.
  • a female screw that is screwed into a male screw (screw protrusion) 76 provided on the cylinder tip 63 of the syringe 60.
  • the same female screw as the female screw 916 (see FIGS. 5A and 5B) provided in the male connector 900 may be provided on the inner peripheral surface of the outer cylinder 15. In this case, the liquid collection tip is screw-locked to the syringe.
  • liquid collection tip 3 can be attached to and detached from the tip of the double cylinder structure.
  • the liquid sampling tip of the present invention may be detachably configured on the tip of a double-cylinder structure regardless of whether or not the flare shape 18 is provided.
  • the syringe injection method using the liquid collection tip of the present invention is not limited to the above embodiment. Using only one syringe 60, the liquid collection tip and the male connector 900 may be alternately connected to the syringe 60, and the suction of the liquid substance into the syringe 60 and the injection of the liquid substance into the patient may be repeated. Since the liquid collection tip can be repeatedly attached to and detached from the syringe 60, unlike the syringe of Patent Document 2 described above, the same syringe 60 can be used to repeatedly suck and inject the liquid material.
  • the present invention is not limited, but can be widely used in the medical field, and can be particularly preferably used when enteral nutrition is performed by a syringe injection method.
  • the catheter to which the syringe is connected may be either a nasal catheter, a PEG catheter, or the like.

Abstract

L'invention concerne une puce d'échantillonnage de liquide (1) qui comprend un élément mâle (10) disposé à une extrémité de la puce d'échantillonnage de liquide, une buse (20) disposée à l'autre extrémité de la puce d'échantillonnage, un canal d'écoulement (17) pénétrant à travers la puce d'échantillonnage de liquide le long de la direction longitudinale de la puce d'échantillonnage de liquide de telle sorte que l'élément mâle et la buse sont en communication, et des parties de maintien (30) pour maintenir la puce d'échantillonnage de liquide. La surface circonférentielle externe de l'élément mâle comprend une surface conique (12) dont le diamètre externe diminue progressivement vers l'extrémité distale de celui-ci. Les parties de maintien comprennent chacune une partie bras (31) qui fait saillie dans la même direction que la buse tout en se séparant de la buse dans la direction radiale.
PCT/JP2020/010829 2019-04-01 2020-03-12 Puce d'échantillonnage de liquide WO2020203143A1 (fr)

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Application Number Priority Date Filing Date Title
JP2021511349A JP7484894B2 (ja) 2019-04-01 2020-03-12 採液チップ

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JP2019-069829 2019-04-01
JP2019069829 2019-04-01

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013212135A (ja) * 2012-03-30 2013-10-17 Jms Co Ltd 経腸栄養療法用カテーテルと、当該経腸栄養療法用カテーテルと医療用回路との接続構造
US20160158110A1 (en) * 2014-12-02 2016-06-09 Covidien Lp Adapter Assembly for Enteral Feeding and Method of Making
US20160206845A1 (en) * 2015-01-20 2016-07-21 Oridion Medical 1987 Ltd. Adapter
WO2016117545A1 (fr) * 2015-01-19 2016-07-28 株式会社ジェイ・エム・エス Collecteur/injecteur de liquide à usage médical
WO2018022631A1 (fr) * 2016-07-25 2018-02-01 Neomed, Inc. Couplage de commande de dosage pour transfert de liquide entéral et raccords et seringues entéraux

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013212135A (ja) * 2012-03-30 2013-10-17 Jms Co Ltd 経腸栄養療法用カテーテルと、当該経腸栄養療法用カテーテルと医療用回路との接続構造
US20160158110A1 (en) * 2014-12-02 2016-06-09 Covidien Lp Adapter Assembly for Enteral Feeding and Method of Making
WO2016117545A1 (fr) * 2015-01-19 2016-07-28 株式会社ジェイ・エム・エス Collecteur/injecteur de liquide à usage médical
US20160206845A1 (en) * 2015-01-20 2016-07-21 Oridion Medical 1987 Ltd. Adapter
WO2018022631A1 (fr) * 2016-07-25 2018-02-01 Neomed, Inc. Couplage de commande de dosage pour transfert de liquide entéral et raccords et seringues entéraux

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