WO2020175894A2 - 다중 코팅된 연질 캡슐 - Google Patents

다중 코팅된 연질 캡슐 Download PDF

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Publication number
WO2020175894A2
WO2020175894A2 PCT/KR2020/002703 KR2020002703W WO2020175894A2 WO 2020175894 A2 WO2020175894 A2 WO 2020175894A2 KR 2020002703 W KR2020002703 W KR 2020002703W WO 2020175894 A2 WO2020175894 A2 WO 2020175894A2
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WIPO (PCT)
Prior art keywords
coating
soft capsule
coated
red ginseng
weight
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PCT/KR2020/002703
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English (en)
French (fr)
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WO2020175894A3 (ko
Inventor
유병일
홍순기
정한주
장동필
Original Assignee
주식회사 한국인삼공사
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Publication of WO2020175894A2 publication Critical patent/WO2020175894A2/ko
Publication of WO2020175894A3 publication Critical patent/WO2020175894A3/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • A23P10/35—Encapsulation of particles, e.g. foodstuff additives with oils, lipids, monoglycerides or diglycerides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P20/00—Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
    • A23P20/10—Coating with edible coatings, e.g. with oils or fats
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P20/00—Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
    • A23P20/10—Coating with edible coatings, e.g. with oils or fats
    • A23P20/15—Apparatus or processes for coating with liquid or semi-liquid products
    • A23P20/18—Apparatus or processes for coating with liquid or semi-liquid products by spray-coating, fluidised-bed coating or coating by casting
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/20—Natural extracts
    • A23V2250/21—Plant extracts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/20—Natural extracts
    • A23V2250/21—Plant extracts
    • A23V2250/2124—Ginseng

Definitions

  • the present invention relates to a multi-coated soft capsule.
  • Encapsulation refers to wrapping or coating the inner material with a polymer film.
  • the outer membrane of the capsule blocks the exposure of the inner material contained in the capsule to oxygen and protects the inner material to keep the inner material stable, and release control
  • Internal substances can be applied to liquids and solids, and gases can also be applied. If the internal substances are liquid, other active ingredients can be dissolved or dispersed.
  • Internal substances include cosmetics, drugs, vaccines, enzymes and microorganisms. , Cells, fragrances, oils, insecticides, pigments, etc. may be applied, and additives such as diluents or stabilizers may be added.
  • the ingredients that make up the outer film of the capsule are mainly used as stable substances when the internal substances are embedded in the desired thickness.
  • the outer film ingredients mainly include inactive polymers, softeners, moisturizers, pigments, and release rate regulators.
  • inactive polymers for example ,Alginate, gelatin, carrageenan, cellulose sulfate, and chitosan are used.
  • the capsule is accurate, timely, safe, convenient, functional, and visual.
  • Types of capsules include seamless capsules and seam type capsules. Seamless capsules are manufactured by dropping method, and as a solution containing the components constituting the inner material and the outer membrane is released through the nozzle. A spherical capsule is formed, and gelatin, agar, and natural gelling substances are used as components that make up the outer film, and the outer film is resistant to heat, acid, and low temperatures. In the case of a core type capsule, water phase and oil phase repulsion are used. Manufactured in a pumping method, specifically internal
  • the gelling film material is manufactured by wrapping the oil phase in a spherical shape by the repulsive force of the oil phase.
  • components constituting the outer film gelatin, glycerin, etc. are produced. It is used, and the outer membrane is known to have no function.
  • the color can be varied to enhance the appearance of the capsule.
  • the diameter can be freely adjusted within the range of 1111111 to 8111111, so that the diameter can be adjusted to suit the usage of the capsule. can do.
  • the capsule manufacturing apparatus disclosed in 1) can be used.
  • the above manufacturing apparatus has a dual discharge path in which the fragrance liquid (internal substance) is discharged and the film material (a solution containing the components constituting the outer film) is discharged.
  • it has a nozzle that forms the initial shape of the fragrance capsule by discharging the membrane material in a form that wraps the fragrance, and the coolant is injected into the lower end of the nozzle, and the shape where the membrane material wraps the fragrance cools and makes the capsule.
  • Patent Literature 1 discloses only the manufacture of capsules for loading cigarette flavor, but not about the manufacture of capsules applicable to the food field.
  • Fluidized bed coating technology is a spray drying method that simply mixes and combines dried solid raw materials.
  • the fluidized bed coating technology produces fine granule, granule, and bead-type formulations (15 1). Since the coating technology was targeted at solid raw materials, it was difficult to use liquid raw materials while maintaining the unique characteristics of oils or flavorings, so there was a limit to the development of various products such as tea and health food, and it was difficult to meet consumer demand. In the production of large bead types, the operation of the fluid bed equipment for a long period of time increases the labor cost, resulting in a decrease in productivity and an increase in product prices.
  • the object of the present invention is to improve the inherent properties of liquid raw materials such as oils or flavorings.
  • the present invention is a soft capsule containing a liquid raw material; A first coating composed of red ginseng extract coated on the surface of the soft capsule; And a second coating composed of red ginseng powder coated on the surface of the first coating; Provides a coated soft capsule.
  • the multi-coated small soft capsule of the present invention maintains the inherent characteristics of liquid raw materials such as oils and flavors filled in the soft capsule, while maintaining the unique characteristics of the multi-coated small soft capsules.
  • 2020/175894 1 (:1 ⁇ 1 ⁇ 2020/002703
  • red ginseng It is easy to consume because there is no adhesion between the liver.
  • physiological activity of red ginseng can be obtained with the red ginseng ingredient used during coating.
  • Figure 1 shows a small soft capsule.
  • FIG. 2 shows the mesh body passage ratio according to the exposure time of the small soft capsule (control group) performed only with the first coating and the small soft capsule (test group) performed both the first and the second coating.
  • Fig. 3 shows the degree of inter-capsule adhesion according to the exposure time of the small soft capsules (control group) with only the first coating and the small soft capsules (test group) with both the first and second coatings.
  • the present invention consists of a soft capsule containing a liquid raw material; a primary coating consisting of red ginseng extract coated on the surface of the soft capsule; and a secondary coating consisting of red ginseng powder coated on the surface of the primary coating; It provides a medium coated soft capsule.
  • the liquid raw material may contain oil, and if it is an oil-based liquid raw material,
  • the oil may be an oil component used in food. It may be natural vegetable oil or processed oil obtained from vegetable sources. Or it may be a natural animal oil or a processed oil obtained from an animal source. For example, the oil may be a flavoring or edible oil used as a food and health supplement.
  • coconut oil vegetable oil, peanut oil, olive oil, Camellia oil, castor oil, palm kernel oil, soybean oil, rapeseed oil, sunflower oil, high-oleic sunflower oil, corn oil, palm olein oil, palm oil, safflower oil, It may be any one selected from the group consisting of oil, evening primrose oil, perilla oil, sesame oil, linseed oil, rice bran oil, squalene, refined oil, mineral oil, red ginseng oil, and combinations thereof.
  • the liquid raw material may additionally contain at least one of flavoring and fat-soluble vitamins, and any raw material that is easily soluble in oils and has functional properties may be included without limitation.
  • the flavoring agent above plays a role of revitalizing the flavor of food.
  • the flavoring agent that can be applied to the present invention can be used without limitation as long as it is included in the food composition.
  • Natural or synthetic flavors can be used, for example, strawberry flavor, banana flavor, peppermint flavor, cinnamon flavor, lemon flavor, raspberry flavor, blueberry flavor, coffee flavor, apple mint flavor, plum flavor, mixed fruit flavor, It may be one selected from the group consisting of apple flavor, menthol flavor and vanilla flavor.
  • This fat-soluble vitamin is a vitamin that is soluble in fat or an organic solvent that dissolves fat, and is not particularly limited in the present invention, specifically, vitamin-in-vitamin I), vitamin E 2020/175894 1»(:1 ⁇ 1 ⁇ 2020/002703
  • It may be one selected from the group consisting of vitamin M, vitamin X, vitamin II, and combinations thereof.
  • 1 ⁇ to 6 ⁇ may be, but is not limited thereto. If the diameter of the soft capsule is less than the limit value, the size of the capsule is too small and the amount lost when multi-coating or ingestion increases. If the diameter exceeds the abnormal value, it may be difficult to coat with a fluid bed device.
  • the film of the soft capsule is glycerin, agar, pectin, steviol glycoside and
  • the coating agent containing sodium alginate may be cured.
  • the coating agent refers to a mixture of ingredients that form the coating before the coating is hardened, and may contain purified water in addition to the gastric components.
  • Glycerin is 1 part by weight to 1 part by weight based on 0 parts by weight of the coating agent.
  • Agar may be contained in an amount of 1 to 5 parts by weight
  • pectin may be contained in an amount of 1 to 5 parts by weight
  • steviol glycosides may be contained in an amount of 0.1 to 5 parts by weight, but is not limited thereto.
  • the glycerin may be included in an amount of 2 parts by weight to 9 parts by weight, 3 parts by weight to 8 parts by weight, 4 parts by weight to 7 parts by weight, and 4 parts by weight to 6 parts by weight.
  • Agar based on parts by weight is 2 parts by weight to 9 parts by weight, 2 parts by weight to 8 parts by weight, 2 parts by weight to 7 parts by weight, 2 parts by weight to 6 parts by weight, 2 parts by weight to 5 parts by weight, 2 parts by weight or less
  • pectin is 1 part by weight to 8 parts by weight, 1 part by weight to 7 parts by weight, 1 part by weight to 5 parts by weight,
  • the steviol glycoside is 0.5 to 5 parts by weight, 0.5 to 4 parts by weight, 0.5 to 3 parts by weight. It may be included in parts by weight, 0.7 parts by weight to 2 parts by weight, and 0.7 parts by weight to 1 part by weight.
  • sodium alginate is 0.1 parts by weight to 4 parts by weight, 0.1 parts by weight to 3 parts by weight, 0.1 parts by weight 2 to 2 parts by weight and 0.1 to 1 part by weight may be included, but are not limited thereto.
  • water may be added to the coating agent in addition to the above components.
  • the content of the component included in the coating agent does not satisfy the above range, The viscosity of the coating agent is not suitable for forming the coating, and thus the coating is not completely hardened even when the soft capsule is manufactured. If the coating is not hardened, the liquid raw material in the coating may leak, and the primary and secondary coating cannot be performed.
  • the viscosity of the coating agent is 300cps to 850cps, 350cps to 800cps, 400cps to
  • the viscosity is less than the lower limit, it is difficult to form the capsule. If the viscosity exceeds the upper limit, it is difficult to dispose of the coating agent from the nozzle through which the coating agent is discharged in the capsule manufacturing apparatus, making it difficult to manufacture the capsule.
  • the film is hardened, 2020/175894 1»(:1 ⁇ 1 ⁇ 2020/002703
  • the film may be deteriorated.
  • Ginseng (/ 3 ⁇ 4 «Yu ⁇ « ⁇ ) is a plant taxonomy
  • Ginseng As a perennial dark herbaceous plant belonging to the genus Ginseng & 1, it has been used as an important medicinal material in oriental medicine for a long time.
  • Ginseng is generally divided into white ginseng and red ginseng according to the processing method, and white ginseng is unprocessed ginseng mined from the field.
  • Red ginseng refers to dried fresh ginseng as it is, and red ginseng is dried by steaming fresh ginseng.
  • various chemical changes such as saponin modification and amino acid change are involved.
  • Red ginseng produces saponin components such as ginsenosides 1 2, 1 3 3, 1, 1 3 2, which do not exist in ginseng due to the heat applied during the manufacturing process, and the unique active ingredients of red ginseng are cancer prevention, cancer cell growth inhibition, blood pressure reduction. It is excellent in function, brain nerve cell protection and learning ability improvement, antithrombosis, and antioxidant activity.
  • the extract is ginseng leaves, young sprouts, body, body shells, stems, stem shells, roots, root shells, root stems, seeds, fruits, immature fruits, ripe fruits, flesh, peel, flowers , Surgery group ⁇ 11 0 11111), pistil group (silver), 110 11111), calyx, surgery, petals, calyx fragments, carpels and combinations thereof.
  • the root stem can be obtained from any one selected from the group consisting of. It is also referred to as a rhizome, and indicates that the stem grows down and acts like a root.
  • the above group represents the entire stamen in one flower, and the above group represents the entire pistil in one flower.
  • As a constituent for making pistils it shows a modified form of leaves, generally referred to as flower leaves.
  • the ginseng may be a root, but is not limited thereto, and extracts obtained from other parts of ginseng may be mixed and used.
  • extract means a substance extracted from raw materials by any method, and is used in the sense of including, without limitation, all of the extract extracted, the concentrate obtained therefrom, the dried product and powder of the concentrate. do.
  • the extract can be obtained by extracting from a raw material or a dried product thereof, and the raw material of the extract can be used without limitation, such as cultivated or commercially available.
  • the above extraction process can be repeated several times, and thereafter, additional steps such as concentration or freeze drying can be performed.
  • the obtained extract is concentrated under reduced pressure to obtain a concentrate, and the concentrate is freeze-dried.
  • a high-concentration extract powder can be prepared using a grinder.
  • the extract includes the fraction obtained by further fractionating the extract.
  • This extract can be extracted by using water, an organic solvent or a mixture thereof as an extraction solvent.
  • the organic solvent is alcohol, preferably a lower alcohol of 00, nucleic acid-nucleic acid), ether, glycerol, propylene glycol, Butylene glycol, ethyl acetate,
  • the mixture of water and organic solvents may preferably be a mixture of water and a lower alcohol of -, and more
  • It may preferably be water.
  • the red ginseng extract can be 20 3 ⁇ 4 urine to 70 3 ⁇ 4 urine, 25 3 ⁇ 4 urine to 65 3 ⁇ 4 urine, 30 3 ⁇ 4 urine to 60 3 ⁇ 4 urine, 35 3 ⁇ 4 urine to 55 3 ⁇ 4 urine, 40 3 ⁇ 4 urine to 50 3 ⁇ 4 urine, but this If the sugar content of the red ginseng extract is less than the lower limit, the red ginseng powder will not be coated on the surface of the soft capsules after the first coating with red ginseng extract and then the second coating with red ginseng powder. If the sugar content of the red ginseng extract exceeds the upper limit, the viscosity of the red ginseng extract increases, so spraying with a fluidized bed apparatus may be difficult.
  • physiological activity may be lowered.
  • the particle size of the red ginseng powder may be 60% or more, 65% or more, 70% or more, 75% or more, 80% or more, 85% or more, 90% or more, 95% or more of the powder passing through 120 mesh, If the particle size of the red ginseng powder is less than the lower limit, red ginseng powder with a large particle size may be included, and the red ginseng powder may not be uniformly coated on the capsule surface during the secondary coating.
  • the coating can be carried out using a fluid bed device.
  • the injection amount for the 1st and 2nd coatings is 1 ⁇ 1 ⁇ /minute to 20 ⁇ 1 ⁇ /minute, 1 ⁇ 1 ⁇ /minute to 15 ⁇ 1 ⁇ /minute, 1 ⁇ 1 ⁇ /minute to 10 ⁇ 1 ⁇ /minute, It can be from 1 ⁇ 1 ⁇ /min to 8/min, and from 1/min to 6/min. If the amount of injection is less than the lower limit, the coating time may take longer. If the amount of injection exceeds the upper limit, the sprayed coating liquid will be sprayed. There is a problem in that the capsules are not dried but are in a wet state, so that the adhesion between the capsules increases and the weight of the capsule itself increases due to the solidification in the bonded state.
  • the red ginseng extract may be included in an amount of 20 parts by weight to 60 parts by weight, and 1 to 20 parts by weight of red ginseng powder, but is not limited thereto.
  • the red ginseng extract Silver may be included in 25 parts by weight to 55 parts by weight, 30 parts by weight to 50 parts by weight, 35 parts by weight to 45 parts by weight.
  • red ginseng powder is 1 to 15 parts by weight, 2 parts by weight. It can be included in parts by weight of 13 parts by weight, 3 parts by weight to 11 parts by weight, and 4 parts by weight to 9 parts by weight.
  • the amount of red ginseng extract and red ginseng powder added does not satisfy the above range, the physiological activity of the multi-coated soft capsule may decrease, and the hardness of the multi-coated soft capsule may be low, so that the liquid raw material may leak due to external impact.
  • the primary coating may additionally contain plant extracts.
  • the liquid may additionally contain plant extracts.
  • the liquid may additionally contain plant extracts.
  • the liquid may additionally contain plant extracts.
  • plant extracts in powder form are added to the first coating of the formulation.
  • 2020/175894 1 (:1 ⁇ 1 ⁇ 2020/002703
  • the plant extract is 1 to 20 parts by weight, for example, 1 to 15 parts by weight, 2 to 13 parts by weight, 3 parts by weight. It may be included in parts by weight of 11 parts by weight and 4 parts by weight of 9 parts by weight.
  • the above plant extracts are Licorice, Angelicae, Hwanggi, Earl of Peony, Baekchul, Sukjihwang, Cheongung, Dermis, Galgeun, Maekmundong, Headworm, Sanyak, Useul, Cassia tora, Wonji, Ginger, Jujube, Goji, Bokbunja, Cheonma, Schisandra, Cornus And one or more selected from the group consisting of a combination thereof
  • the plant extract may be in the form of a powder obtained by freeze-drying the plant extract.
  • the hardness of the multi-coated soft capsule is 0.51 ⁇ 51 ⁇ for example, 0.71 ⁇
  • a soft capsule was prepared by using a filler and a coating agent containing glycerin, agar, pectin, steviol glycoside, sodium alginate, and purified water.
  • 45 ginseng extract was placed on the surface of the prepared soft capsule using a fluid bed device, and the injection amount was adjusted.
  • the first coating was produced by spraying at 2/min. After that, red ginseng powder having a particle size of 85% or more of the powder passing through the 120 mesh sieve in the first coated soft capsule was used in a fluidized bed apparatus to make the injection amount 5/min.
  • the coated soft capsule had no grooves, wrinkles, patterns, or cracks, had a unique color and flavor, and had a hardness of 21 ⁇ or more, and leakage of liquid raw materials inside the capsule. There was no adhesion between capsules even after long-term storage.
  • a soft capsule was prepared using a filler and a coating agent containing glycerin, agar, pectin, steviol glycoside, sodium alginate and purified water.
  • a coating solution prepared by adding plant extract powder to the red ginseng extract was sprayed with a fluidized bed device at 2111 hair/min to produce a primary coating.
  • 85% of the powder passing through the 120 mesh sieve in the primary coated soft capsule Red ginseng powder having an ideal penetration size was sprayed with a fluid bed device at an injection amount of 5111 ⁇ to create a secondary coating.
  • the medium coated soft capsule produced has no grooves, wrinkles, patterns, cracks, and has its own color and flavor. It had a hardness of 21 ⁇ or more, and there was no leakage of liquid raw materials inside the capsule, and there was no adhesion between capsules even when stored for a long time.
  • the heavy-coated soft capsule uses the liquid raw material contained in the soft capsule. It can be applied in various ways by changing it according to the purpose. For example, you can prevent bad breath after eating or smoking by adding peppermint and lemon scent as a liquid raw material, and menthol scent as a liquid raw material to prevent drowsiness while driving. can do.
  • the present invention is a step of manufacturing a soft capsule containing a liquid raw material; A first coating step of coating a primary coating composed of red ginseng liquor on the surface of the soft capsule; And a second coating step of coating a secondary coating made of red ginseng powder on the surface of the primary coating material.
  • the first and second coatings can be carried out using a fluid bed device, respectively.
  • the content is not limited by the following manufacturing examples and experimental examples.
  • Moist heat was performed at 121 ⁇ 1 O C for 1 minute.
  • the finished material was put in a hot air drying room and dried under the following conditions for each ingredient: Red ginseng root was dried at 60 ⁇ 3 O C for 72 hours, and red rice ginseng was 60 ⁇ 3. Dried for 48 hours at O C. The dried raw materials were allowed to cool for at least 12 hours. After the dried raw materials were taken over, the red ginseng grinder was set to 120 mesh and operated, red ginseng roots and red rice ginseng were added to the red ginseng grinder and crushed. I did.
  • the red ginseng powder prepared in 5 has a flavor of red ginseng in the form of a light yellow powder, and has no off-flavor.
  • the red ginseng component (total saponin) content was 35 mg/g or more, and the red ginseng powder particle size passes through 120 mesh.
  • the powder was 85% or more, and the moisture was 4.3 ⁇ 1.0%, and no foreign matter was detected.
  • Red ginseng concentrate was prepared by concentrating at 50 60 O C to TL O Brix. The solid content of the concentrate was 64%.
  • the content of red ginseng components contained in the prepared red ginseng concentrate was 70.0 mg/g or more when converted to a 40% moisture content, and the sum of ginsenosides Rgl, Rbl, and Rg3 was converted to a 40% moisture content. It was more than 5.5 mg/g.
  • the red ginseng concentrate was dark brown and had no off-flavor.
  • Licorice (Glycyrrhiza uralensis Fischer, Glycyrrhiza glabra Linne, roots and roots) was added 13 times the weight of water to 1.0 kg, and extracted twice for 8 hours at 80 O C. The filtrate was filtered using a filter. The filtrate was concentrated to 70 O Brix at 50 60 O C using a rotary pressure condenser (BUCHI, R-220) to prepare a licorice concentrate. Licorice concentrate was freeze-dried (0PER0N, FDT- 12012) to obtain licorice extract powder.
  • the filling material and the film were mixed by dissolving the following raw materials.
  • the film blended at the blending ratio of Table 1 had a viscosity of 60 -8, and was stored at 60 o (:.
  • the capsule manufacturing apparatus disclosed in Korean Patent Publication No. 2016-0116827 was used for the manufacture of the capsule.
  • perfume is disclosed as a core included in the capsule
  • makjae is disclosed as a capsule film, but in the present invention, in Table 1 and Table 2 above.
  • a capsule point equipped with a nozzle a capsule was manufactured with a manufacturing device, dried, and further cured to produce a hard capsule, but in the present invention, a drying step or an additional curing step was excluded.
  • the manufactured soft capsule was suitable for edible because the outer membrane was soft compared to the hard capsule for edible use.
  • the manufactured capsule was a seamless (8681111688) type capsule.
  • the size of the manufactured capsule was under a microscope (0 ⁇ 1 ⁇ 118 and
  • the blending ratio of the raw materials used when coating the small soft capsule is as follows.
  • the first coating was performed using a coating solution and a fluidized layer coating method.
  • the red ginseng concentrate and licorice extract powder prepared in Preparation Examples 2 and 3 were used. Licorice extract powder was dissolved in the red ginseng concentrate. As a seed, 49358
  • the small soft capsule prepared in Preparation Example 4 was used.
  • the ratio of the dried small soft capsule, red ginseng concentrate, and licorice extract powder was 5:4:0.5.
  • the red ginseng concentrate of Preparation Example 2 was added with purified water to give a sugar content of 45.
  • the coating solution was prepared by stirring with a stirrer at a speed of 55+5 RPM and a temperature of 40 ⁇ 5° (:).
  • the capsules were placed in a fluidized bed unit ⁇ (31 1 5-1, £01(3 ⁇ 4. ,! ⁇ 1) After injection into the acid, the temperature of the coating machine was adjusted to 40°0 or less.
  • the coating solution was sprayed in 2/spray. After spraying was completed, it was dried at 40°0 or less for more than 20 minutes.
  • the secondary coating was used as a coating and was carried out by the fluidized layer coating method.
  • the red ginseng powder prepared in Preparation Example 1 was used, and as the seed, the first coated small soft capsules prepared in Preparation Example 5 were used.
  • the weight-to-weight ratio of the first coated small soft capsules and red ginseng powder was 95:5.
  • the red ginseng powder process dihydrate weight was melted at a ratio of 2:8, homogenized with an upper-driving mixer, and then a fluidized bed coating machine using a micro-continuous pump. The nozzle was sprayed inside. 2020/175894 1»(:1 ⁇ 1 ⁇ 2020/002703
  • the coating solution was sprayed by pre-sale. After spraying was completed, it was dried at 40°0 or less for 20 minutes or more.
  • the medium-coated small soft capsule is a brown pill type, has no grooves, wrinkles, patterns, cracks, has a unique color and flavor, and has no off-flavor.
  • multiple coatings The hardness of the small soft capsules was 21 ⁇ or more, and the colon bacillus group was confirmed as negative. Visual confirmation The coated small soft capsules were sealed by stick packaging. The weight deviation (%) of each stick was confirmed. There were 2 or less deviations of 5-10%.
  • the durability of the primary and secondary coated capsules was confirmed by measuring the hardness. Measured. Table 4 shows the hardness measurement results of the primary coated capsules, and Table 5 shows the hardness measurement results of the secondary coated capsules (multi-coated capsules).
  • the primary coated capsule was confirmed to be 2.41 ⁇ , which is the result value within 11 to 51 units, which is a general hardness that can be made by humans at the corresponding diameter, and the multi-coated capsule is a small soft capsule without coating or a first coated capsule. Compared to this, the ratio of capsules that were broken even by external impact was lower due to higher hardness, and accordingly, the form of liquid raw materials such as oils and flavors was maintained.
  • the granules are dried by forced hot air, and moisture is easily adsorbed when exposed to the atmosphere, and there is a phenomenon in which the quality of granules decreases rapidly due to the formation of viscous and sticking lumps.
  • test group small soft capsules coated with red ginseng concentrate in Preparation Example 5 and second coated with red ginseng powder were used.
  • the control group and the test group were used for 3 hours under normal indoor conditions of 25 o (:, 50- It was exposed to 60% 1111, and the degree of adhesion between the coated capsules by exposure time and lumping was evaluated by passing through the mesh body as a pass rate. If the capsule is lumped, it cannot pass through the sieve and the rate of passage is lowered.
  • the mesh passing ratio (%) of the control group and the test group is shown in Table 6 below.

Abstract

본 발명은 다중 코팅된 연질 캡슐에 관한 것으로, 액상 원료를 포함하는 연질 캡슐을 홍삼 추출물로 1차 코팅하고, 홍삼 분말로 2차 코팅함으로써, 연질 캡슐 내에 오일류, 착향류 등의 액상 원료의 고유 특성을 유지하면서도 다중 코팅된 소형 연질 캡슐끼리 간에 접착이 없어서 섭취가 용이하다.

Description

명세서
발명의명칭:다중코팅된연질캡슐 기술분야
[1] 본발명은다중코팅된연질캡슐에관한것이다.
배경기술
[2] 캡슐화란내부물질을고분자막으로감싸거나코팅하는것을말한다.캡슐의 외막은캡슐내에포함된내부물질이산소에노출되는것을차단하여내부 물질을보호함으로써내부물질을안정하게유지시키고,방출제어하는역할을 한다.내부물질은액체,고체가적용될수있고,기체도적용가능하다.내부 물질이 액상일경우에는다른활성성분이용해또는분산될수있다.내부 물질로는화장품,약품,백신,효소,미생물,세포,향,오일,살충제,색소등이 적용될수있고,희석제와같은첨가제또는안정제가추가로첨가될수있다.
[3] 캡슐의외막을구성하는성분은원하는두께로내부물질을포매하였을때에 안정적인물질이주로사용되고있다.외막성분에는주로비활성고분자, 유연제,보습제,색소,방출속도조절제가포함된다.예를들면,알지네이트, 젤라틴,카라기난,셀룰로오스설페이트,키토산이이용되고있다.
[4] 캡슐은사용처에따라서정확성，적시성 ,안전성，편리성 ,기능성 ,시각적
효과의기능을갖는다.특히식품분야에서캡슐제형이이용될때에는기능성, 편리성효과가중요하다.식품의경우에는캡슐내에포함되는유효성분의생리 활성이유지되어야하며,캡슐끼리접착하여덩어리지지않으면서섭취가 편하고,이에따라상품성도높아지므로,기능성과,섭취편의성을충족시킬수 있는캡슐제형에대한연구가필요한실정이다.
[5] 캡슐의종류로서는심리스캡슐 (seamless capsule)과심타입캡슐 (seam type capsule)이있다.심리스캡슐은적하방식으로제조되며,내부물질과외막을 구성하는성분을포함하는용액이노즐을통해방출되면서구형의캡슐이 형성되며,외막을구성하는성분으로는젤라틴,아가,천연겔화물질등이 사용되고,외막은열,산,저온에내성이 있다.심타입캡슐의경우에는수상과 유상의반발력을이용하여펌핑방식으로제조된다.구체적으로내부
물질 (유상)을밀어내고,내부물질이노즐을통해나오는순간수상물질에 노출되면서유상의반발력에의해겔화피막물질이유상을구형으로감싸면서 제조된다.외막을구성하는성분으로젤라틴,글리세린등이사용되며 ,외막은 기능이없는것으로알려져있다.
[6] 심리스캡슐은심타입캡슐에비해서,투명하고광택이 있는구형의캡슐이 제조되고,지용성성분을직접적으로캡슐화할수있으며 ,캡슐자체의크기를 감소/증가시켜서내부물질의용량을조절할수있다.또한,내부물질의산화를 막기때문에방습벽 (vapor barrier)기능도한다.외막을구성하는성분을 2020/175894 1»（：1^1{2020/002703
2 포함하는용액에다양한색소를첨가함으로써색상을다양하게하여캡슐의 외관을미려하게할수있다.또한,직경을 1111111내지 8111111사이의범위내에서 자유롭게조절이가능하여캡슐의쓰임에맞도록직경을조절할수있다.
[7] 심리스캡슐제조시에는한국공개특허공보제2016-0116827호（이하,특허문헌
1이라함）에개시된캡슐제조장치를사용할수있다.상기제조장치는 향액（내부물질）이배출되는경로와,막재（외막을구성하는성분이포함된 용액）가배출되는경로가각각있는이중배출구조를갖는다.또한막재가 향액을감싸는형태로배출되어향캡슐의초기형태를형성하는노즐을가지며, 노즐의하단에냉각재가투입되면서 ,막재가향액을감싼형태가냉각되어 캡슐이제조된다.그러나,특허문헌 1에서는담배의향을적재하기위한캡슐 제조에대해서만개시되어 있을뿐,식품분야에적용가능한캡슐의제조에 대해서는개시되어있지않다.또한,캡슐의사용처에따라각각의기능성 요소들을충족해야하므로,특허문헌 1에개시된캡슐제조장치를이용하여 화장품에적용가능한캡슐을제조하고자할때에는외막에포함되는성분,또는 내부물질에대한검토가추가적으로필요하다.또한,특허문헌 1에서사용되는 캡슐은건조공정과추가경화과정을포함하고있어외막이단단한하드 캡슐이므로식품에적용하기에는어려움이있었다.
[8] 유동층코팅기술은건조된고형원료를단순히혼합하고결합하는분무건조 방식으로,유동층코팅기술로미세한과립,과립,구슬모양의비드（15  1）타입의 제형이제조된다.이와같이종래의유동층코팅기술은고형원료를대상으로 하였기때문에오일류또는착향료고유의특징을유지한상태로액상원료의 사용이어려워서차나,건강식품등의다양한제품개발에한계가있었고, 소비자요구에부응하기어려웠다.또한,입자크기가큰비드타입제조시에는 유동층기기를장시간운용함으로써임가공비가증가되어생산성이떨어지고 제품가격이상승되는요인이되어왔다.
발명의상세한설명
기술적과제
[9] 본발명의목적은오일류또는착향료와같은액상원료의고유특성을
유지하면서도,최종제조된가공물간에접착이없는캡슐을제공하는것이다. 과제해결수단
[1이 상기과제를해결하기위하여,본발명은액상원료를포함하는연질캡슐; 연질캡슐의표면에코팅되는홍삼추출물로이루어진 1차코팅물;및 1차 코팅물의표면에코팅되는홍삼분말로이루어진 2차코팅물;로이루어진다중 코팅된연질캡슐을제공한다.
발명의효과
[11] 본발명의다중코팅된소형연질캡슐은연질캡슐내에충전된오일류,착향류 등의 액상원료의고유특성을유지하면서도다중코팅된소형연질캡슐끼리 2020/175894 1»（：1^1{2020/002703
3 간에접착이없어서섭취가용이하다.또한,코팅시사용된홍삼성분으로 홍삼의생리활성효과도얻을수있다.
도면의간단한설명
[12] 도 1은소형연질캡슐을나타낸다.
[13] 도 2는 1차코팅만수행한소형연질캡슐（대조군）,및 1차및 2차코팅모두 수행한소형연질캡슐（시험군）의노출시간에따른 메쉬체통과비율을 나타낸다.
[14] 도 3은 1차코팅만수행한소형연질캡슐（대조군）,및 1차및 2차코팅모두 수행한소형연질캡슐（시험군）의노출시간에따른캡슐간접착정도를 나타낸다.
발명의실시를위한최선의형태
[15] 이하,본발명을상세하게설명한다.
[16] 본발명은액상원료를포함하는연질캡슐;연질캡슐의표면에코팅되는홍삼 추출물로이루어진 1차코팅물;및 1차코팅물의표면에코팅되는홍삼분말로 이루어진 2차코팅물;로이루어진다중코팅된연질캡슐을제공한다.
[17] 상기액상원료는오일을포함할수있고,오일베이스의 액상원료라면
제한없이적용할수있다.상기오일은식품에사용되는오일성분일수있다. 천연식물성오일또는식물성공급원으로부터얻어지는가공오일일수있다. 또는천연동물성오일또는동물성공급원으로부터얻어지는가공오일일수 있다.예를들면,상기오일은식품및건강기능식품으로사용되는착향료또는 식용오일류일수있다.예를들면,코코넛유,채종유,땅콩유,올리브유,동백유, 피마자유,팜핵유,대두유,평지씨유,해바라기유,고-올레산해바라기유, 옥수수유,팜올레인유,팜유,홍화유,
Figure imgf000005_0001
오일,달맞이꽃 종자유,들기름,참기름,아마인유,미강유,스쿠알렌,정제어유,미네랄오일, 홍삼오일및이의조합으로이루어진군으로부터선택되는어느하나일수 있다.
[18] 상기액상원료는착향료및지용성비타민중적어도하나를추가로포함할수 있으며,오일류에쉽게용해되고,기능성이 있는원료라면제한없이포함될수 있다.
[19] 상기착향료는식품의향을살려주는역할을한다.본발명에적용될수있는 착향료는식품조성물에포함되는것이라면제한없이사용할수있다.
천연착향료또는합성착향료가사용될수있다.예를들면,딸기향,바나나향, 페퍼민트향,계피향,레몬향,라즈베리향,블루베리향,커피향,애플민트향, 매실향,믹스후르츠향,애플향,멘톨향및바닐라향으로이루어진군으로부터 선택되는하나일수있다.
[2이 상기지용성비타민은지방또는지방을녹이는유기용매에녹는비타민으로서 본발명에서특별히제한되지않으며,구체적으로비타민人비타민 I）,비타민 E 2020/175894 1»（：1^1{2020/002703
4 비타민므,비타민 X,비타민 II및 이의조합으로이루어지는군으로부터 선택되는하나일수있다.
[21] 상기 연질캡슐의직경은
Figure imgf000006_0001
내지 7 1®, 1■내지 6■일수있으나,이에 한정하지 않는다.연질캡슐의 직경이하한값미만일경우에는캡슐의크기가너무작아서다중코팅시 , 섭취시에손실되는양이 많아진다.연질캡슐의 직경이상한값을초과할 경우에는유동층기기로코팅이 어려울수있다.
[22] 상기 연질캡슐의피막은글리세린,한천,펙틴,스테비올배당체 및
알긴산나트륨을포함하는피막제가경화된것일수있다.피막제는피막이굳기 전에 피막을이루는성분의혼합물을나타내며,위성분외에정제수가포함될 수있다.피막제 0중량부기준으로글리세린은 1중량부내지 중량부, 한천은 1중량부내지 중량부,펙틴은 1중량부내지 중량부,스테비올 배당체는 0.1중량부내지 5중량부,알긴산나트륨은 0.1중량부내지 5중량부로 포함될수있으나,이에 한정하지 않는다.
[23] 피막제 ^0중량부기준으로상기글리세린은 2중량부내지 9중량부, 3중량부 내지 8중량부, 4중량부내지 7중량부, 4중량부내지 6중량부로포함될수 있다.피막제 100중량부기준으로한천은 2중량부내지 9중량부, 2중량부내지 8중량부, 2중량부내지 7중량부, 2중량부내지 6중량부, 2중량부내지 5 중량부, 2중량부내지 4중량부로포함될수있다.피막제 100중량부기준으로 펙틴은 1중량부내지 8중량부, 1중량부내지 7중량부, 1중량부내지 5중량부,
1중량부내지 4중량부, 1중량부내지 3중량부로포함될수있다.피막제 100 중량부기준으로스테비올배당체는 0.5중량부내지 5중량부, 0.5중량부내지 4 중량부, 0.5중량부내지 3중량부, 0.7중량부내지 2중량부, 0.7중량부내지 1 중량부로포함될수있다.피막제 100중량부기준으로알긴산나트륨은 0.1 중량부내지 4중량부, 0.1중량부내지 3중량부, 0.1중량부내지 2중량부, 0.1 중량부내지 1중량부로포함될수있으나,이에 한정하지 않는다.아울러, 피막제에는상기성분외에물을첨가할수있다.상기피막제에포함되는 성분의 함량이상기 범위를만족하지 않는경우에는피막제의 점도가피막을 형성하기에 적합하지 않고,이에 따라연질캡슐을제조하여도피막이완전히 굳지 않게된다.피막이굳지 않으면피막내의 액상원료가누출될수있고, 1차, 2차코팅을할수없다.
[24] 상기피막제의 점도는 300cps내지 850cps, 350cps내지 800cps, 400cps내지
750cps, 450cps내지 700cps, 500cps내지 650cps일수있고,이에 한정하지 않는다. 점도가하한값미만일경우에는캡슐성형이 어렵다.점도가상한값을초과할 경우에는캡슐제조시 ,캡슐제조장치 내의피막제가배출되는노즐에서 피막제의 배출이용이하지 않아캡슐의 제조가어려워진다.또한,피막제는 45 내지 80ᄋ（:,예컨대 50°0내지 75ᄋ（:, 55°0내지 70ᄋ（:, 60°0내지 65ᄋ（：에서보관될수 있다.피막제보관온도가상기범위를벗어나는경우에는피막제가굳거나, 2020/175894 1»（：1^1{2020/002703
5 피막제가변질될수있다.
[25] 인삼（/ ¾ «유切«^）은식물분류학상으로오갈피나무과
Figure imgf000007_0001
인삼속 &1 幻에속하는다년생음지성초본식물로서오래 전부터 한방에서 중요한약재로사용되었다.인삼은일반적으로가공방법에따라백삼과 홍삼으로구분되며,백삼은밭에서 채굴한가공되지 아니한인삼즉,수삼을 그대로건조한것을지칭하며홍삼은수삼을증숙하여 건조가공한것으로제조 과정에서사포닌변형과아미노산변화등여러 화학적인변화가수반된다. 홍삼은제조과정에서 가해지는열에 의해 인삼에존재하지 않는진세노사이드 1 2, 1¾3, 1, 1¾2등의사포닌성분이 생성되며,홍삼특유의유효성분은암 예방작용,암세포성장억제작용,혈압강하작용,뇌신경세포보호및학습 능력 개선작용,항혈전작용,항산화작용등이우수하다.
[26] 본발명에 있어서,추출물은인삼의 잎,어린새싹,본체,본체 껍질,줄기,줄기 껍질,뿌리,뿌리 껍질,뿌리줄기,종자,열매,미숙과,완숙과,과육,과피,꽃, 수술군知11 0 11111）,암술군（은），110 11111）,꽃받침 ,수술,꽃잎,꽃받침조각,심피 및 이들의조합으로이루어진군으로부터선택되는어느하나로부터수득될수 있다.상기뿌리줄기는근경이라고도하며 ,줄기가지하로자라나뿌리와같은 역할을하는것을나타낸다.상기수술군은하나의꽃에 있는수술전체를 나타내며,상기 암술군은하나의꽃에 있는암술전체를나타낸다.상기심피는 꽃의 암술을만드는구성요소로일반적으로화엽이라고총칭되는잎의 변형 형태를나타낸다.상기 인삼은뿌리일수있으나,이에 한정되지 아니하며, 인삼의다른부위에서 얻어진추출물을혼합하여사용할수있다.
[27] 본발명에서 일컫는 "추출물”은원료로부터 임의의 방법으로추출된물질을 의미하며，이렇게추출된추출액 ,이로부터 얻을수있는농축액,상기농축액의 건조물및분말을제한없이모두포함하는의미로사용된다.
[28] 상기추출물은원료또는이의건조물로부터추출하여 얻을수있으며,상기 추출물의 원료는재배한것또는시판되는것등제한없이사용할수있다.
[29] 상기추출물을원료로부터추출하여수득할때,추출방법으로는용매추출법, 초음파추출법,여과법 및환류추출법등종래 알려진통상적인추출방법을 모두사용할수있으며,바람직하게는용매추출법이나환류추출법을
이용함으로써 제조할수있다.상기추출과정은수회 반복할수있으며 ,이후에 농축또는동결건조등의단계를추가적으로거칠수있다.구체적으로,수득한 추출물을감압농축하여농축액을얻고,상기농축액을동결건조시킨후 분쇄기를이용하여고농도의추출분말을제조할수있다.추출물은추출물을 추가적으로분획하여 얻은분획물도포함한다.
[3이 상기추출물은물,유기용매또는이들의혼합물을추출용매로하여추출될수 있다.상기유기용매는알코올,바람직하게는 00의 저급알코올,핵산知-핵산）, 에테르,글리세롤,프로필렌글리콜,부틸렌글리콜,에틸아세테이트,
메틸아세테이트,디클로로메탄,클로로포름,에틸아세테이트,벤젠및이들의 2020/175894 1»（：1^1{2020/002703
6 혼합용매로이루어지는군으로부터선택되는어느하나일수있다.물및 유기용매의혼합물을추출용매로사용하는경우,물및유기용매의혼합물은 바람직하게는물및 - 의 저급알코올의혼합물일수있고,더욱
바람직하게는물일수있다.
[31] 상기홍삼추출물은 20 ¾뇨내지 70 ¾뇨, 25 ¾뇨내지 65 ¾뇨, 30 ¾뇨내지 60 ¾뇨, 35 ¾뇨내지 55 ¾뇨, 40 ¾뇨내지 50 ¾뇨일수있으나,이에 한정하지 않는다.홍삼추출물의 당도가하한값미만이면홍삼추출물로 1차코팅후,홍삼 분말로 2차코팅할때에홍삼분말이 연질캡슐표면에코팅되지 않게되어다중 코팅된연질캡슐이라하더라도캡슐간의 접착이 여전히남아있게된다.홍삼 추출물의 당도가상한값을초과하면홍삼추출물의 점도가높아지기 때문에 유동층기기로분무시에분무가어려울수있다.
[32]
Figure imgf000008_0001
미만일경우에는생리활성이낮아질수있다.
[33] 상기홍삼분말의 입도는 120메쉬를통과하는분말이 60%이상, 65%이상, 70%이상, 75%이상, 80%이상, 85%이상, 90%이상, 95%이상일수있으나, 이에 한정하지 않는다.상기홍삼분말의 입도가하한값미만일경우에는입도가 큰홍삼분말이포함될수있고, 2차코팅시에 캡슐표면에홍삼분말이균일하게 코팅되지 않을수있다.
[34] 상기코팅은유동층기기를이용하여수행될수있다. 1, 2차코팅시분사량은 1 ^1公/분내지 20^1公/분, 1 ^1公/분내지 15^1公/분, 1 ^1公/분내지 10^1公/분, 1 ^1公/분내지 8 /분, 1 /분내지 6 /분일수있다.상기분사량이하한값미만일경우에는 코팅에 걸리는시간이 길어질수있다.상기분사량이상한값을초과할경우에는 분사된코팅액이건조되지 않고젖은상태로존재하여 캡슐간접착이 많아지고 접착된상태로고결되어 캡슐자체의무게가증가하게되므로부양되지 않아 작은구슬타입으로제형화되지 않는문제점이 있다.
[35] 상기 연질캡슐 50중량부에 대해서,홍삼추출물은 20중량부내지 60중량부, 홍삼분말 1내지 20중량부로포함될수있으나,이에 한정하지 않는다.상기 연질캡슐 50중량부에 대해서,홍삼추출물은 25중량부내지 55중량부, 30 중량부내지 50중량부, 35중량부내지 45중량부로포함될수있다.상기 연질 캡슐 50중량부에 대해서,홍삼분말은 1중량부내지 15중량부, 2중량부내지 13중량부, 3중량부내지 11중량부, 4중량부내지 9중량부로포함될수있다. 홍삼추출물,홍삼분말의 첨가량이상기 범위를만족하지 않으면다중코팅된 연질캡슐의 생리활성이감소할수있고,다중코팅된연질캡슐의 경도가낮아 외부충격에의해 액상원료가누출될수있다.
[36] 1차코팅물은식물추출물을추가로포함할수있다.예를들어,상기 액체
제형의 1차코팅물에분말제형의식물추출물을부분적으로또는완전히 2020/175894 1»（：1^1{2020/002703
7 용해시켜 1차코팅에사용할수있다.이경우연질캡슐 50중량부에대해서, 식물추출물은 1중량부내지 20중량부,예컨대 1중량부내지 15중량부, 2 중량부내지 13중량부, 3중량부내지 11중량부, 4중량부내지 9중량부로 포함될수있다.
[37] 상기식물추출물은감초,당귀,황기,백작약,백출,숙지황,천궁,진피,갈근, 맥문동,두충,산약,우슬,결명자,원지,생강,대추,구기자,복분자,천마,오미자, 산수유및이의조합으로이루어진군으로부터선택되는하나이상의
원료로부터추출된것일수있다.상기의식물추출물은예시한것일뿐이며, 식품조성물에사용되는식물주줄물이라면본발명에제한없이적용할수있다. 추출시사용되는원료의부위,추출물의정의,추출방법,추출용매는상기에 기재한바와같으므로설명을생략한다.
[38] 상기식물추출물은식물추출물을동결건조하여수득한분말형태일수있다.
[39] 상기다중코팅된연질캡슐의경도는 0.51 ^내지 51江\예컨대 0.71 ^내지
라 !5, 0.9 모내지 41 5, 1.2 모내지 !5, 1.5 모내지 !5일수있으나,이에 한정되지않는다.상기경도가하한값미만일경우에는연질캡슐내의 액상 원료가누출될수있다.상기경도가상한값을초과할경우에는저작하기에 어려워식품으로섭취하기어려울수있다.
[4이 본발명의한실시예에서는 MCT오일,페퍼민트향,비타민 £를포함하는
충전물과,글리세린,한천,펙틴,스테비올배당체,알긴산나트륨및정제수를 포함하는피막제를이용하여연질캡슐을제조하였다.제조된연질캡슐의 표면에 45 인홍삼추출물을유동층기기를사용하여,분사량을 2 /분으로 분사하여 1차코팅물을생성하였다.그후, 1차코팅된연질캡슐에 120메쉬체를 통과하는분말이 85%이상인입도를가지는홍삼분말을유동층기기를 사용하여분사량 5 /분으로분사하여 2차코팅물을생성하였다.제조된다중 코팅된연질캡슐은홈,주름,무늬,갈라짐이없고,고유의색택과향미를 가지며,경도가 21 ^이상이었고,캡슐내부의액상원료의누출이없었으며, 장시간보관하여도캡슐간접착이없었다.
[41] 본발명의한실시예에서는 MCT오일,페퍼민트향,비타민 £를포함하는
충전물과,글리세린,한천,펙틴,스테비올배당체,알긴산나트륨및정제수를 포함하는피막제를이용하여연질캡슐을제조하였다.제조된연질캡슐의 표면에
Figure imgf000009_0001
홍삼추출물에식물추출물분말을첨가하여제조한코팅액을 유동층기기로 2111모/분으로분사하여 1차코팅물을생성하였다.그후, 1차코팅된 연질캡슐에 120메쉬체를통과하는분말이 85%이상인입도를가지는홍삼 분말을유동층기기를사용하여분사량 5111ᄊ분으로분사하여 2차코팅물을 생성하였다.제조된다중코팅된연질캡슐은홈,주름,무늬,갈라짐이없고, 고유의색택과향미를가지며,경도가 21 ^이상이었고,캡슐내부의 액상원료의 누출이없었으며,장시간보관하여도캡슐간접착이없었다.
[42] 본발명에따른다중코팅된연질캡슐은연질캡슐내에포함되는액상원료를 목적에따라변경함으로써다양하게응용할수있다.예를들면,액상원료로서 페퍼민트향,레몬향을넣음으로써식사또는흡연후에구취를방지할수있고, 액상원료로멘톨향을넣음으로써운전시에졸음을방지할수있다.
[43] 또한,본발명은액상원료를포함하는연질캡슐을제조하는단계 ;상기연질 캡슐의표면에홍삼주줄물로이루어진 1차코팅물을코팅하는제 1코팅단계; 및상기 1차코팅물의표면에홍삼분말로이루어진 2차코팅물을코팅하는제 2 코팅단계;를포함하는다중코팅된연질캡슐의제조방법을제공한다.
[44] 상기제 1및제 2코팅은각각유동층기기를이용하여수행될수있다.
[45] 상기액상원료, 1차코팅물, 2차코팅물및다중코팅된연질캡슐에대한
내용은상술한바와같으므로구체적인설명을생략한다.
발명의실시를위한형태
[46] 이하,본발명을제조예및실험예에의해상세히설명한다.
[47] 단,하기제조예및실험예는본발명을예시하기위한것일뿐,본발명의
내용이하기제조예및실험예에의해한정되는것은아니다.
[48] 제조예 1.흥삼분말의제조
[49] 건조된홍삼（P. ginseng C.A. Meyer,뿌리 70%,잔미 30%）의상태및이물오염 여부를점검하고,세척수를분사하여세척하였다.세척이완료된원료는전용 선반에적재하였다.세척완료된원료를습열기에투입하고다음의원료별 조건으로습열하였다.홍삼근은 121±2OC에서 5분간습열하고,홍미삼은
121±1OC에서 1분간습열하였다.습열이완료된원료를열풍건조실에투입하고, 다음의원료별조건으로건조하였다.홍삼근은 60±3OC에서 72시간동안 건조하고,홍미삼은 60±3OC에서 48시간동안건조하였다.건조완료된원료는 12시간이상방냉하였다.건조완료된원료를인수하고,홍삼분쇄기를체망 120메쉬로설정하여가동시킨후홍삼근및홍미삼을적량씩홍삼분쇄기에 투입하여분쇄하였다.
[5이 제조된홍삼분말은연황색의분말상으로홍삼의향미를가지며 ,이미 ,이취가 없었다.홍삼성분（총사포닌）함량은 35 mg/g이상이었고,홍삼분말의입도는 120메쉬를통과하는분말이 85%이상인분말이었다.수분은 4.3±1.0%였으며 이물은불검출되었다.
[51] 제조예 2.흥삼추출물의제조
[52] 건조된홍삼（P. ginseng C.A. Meyer,뿌리 75%,잔미 25%） 500g에 6배의
증류수를가해 85OC에서 W시간추출하고추출액을여과하여 0- L0OC로 냉각하였다.잔사에대해서는 6배의증류수를가해 W시간추출을 1~4회추가로 실시하여추출액을여과후모두합하여 0- L0OC로냉각하였다.냉각이완료된 추출액을 4OC에서 10~20분동안 6,000rpm으로원심분리（（주）한일사이메드, Supra 22K）하여침전물을제거하고회전감압농축기（BUCHI, R-220）를이용하여
50 60OC에서 TLOBrix가되도록농축하여홍삼농축액을제조하였다.홍삼 농축액의고형분함량은 64%였다.
[53] 제조된홍삼농축액에포함된홍삼성분의함량은수분함량 40%기준으로 환산시에 70.0 mg/g이상이었고,진세노사이드 Rgl, Rbl, Rg3의합은수분함량 40%기준으로환산시에 5.5 mg/g이상이었다.홍삼농축액은암갈색이었으며 , 이미,이취가없었다.
[54] 제조예 3.감초추출물및,이의분말의제조
[55] 감초 (Glycyrrhiza uralensis Fischer, Glycyrrhiza glabra Linne,뿌리와뿌리줄기 ) 1.0 kg에중량대비 13배수의물을가하고, 80OC에서 8시간 2회추출하고
Figure imgf000011_0001
필터를이용하여여과하였다.여액은회전감압농축기 (BUCHI, R-220)를이용하여 50 60OC에서 70OBrix가되도록농축하여감초농축액을 제조하였다.감초농축액을동결건조 (0PER0N, FDT-12012)하여감초추출물 분말을수득하였다.
[56] 제조된감초추출물분말의성상은밝은노란색이었다.
[57] 제조예 4.소형연질캡슐의제조
[58] 건강기능식품공전,식품공전,식품첨가물공전에정하는적합한원료를
구입하여서기준및규격을검사한후적합품만사용하였다.충전물과피막은 하기원료를용해하여배합하였다.
[59] [표 1]
Figure imgf000011_0002
[60] [표 2]
Figure imgf000011_0003
[61] 표 1의배합비로배합된피막은점도가 60 ?8이었으며 , 60ᄋ(：에서보관하였다. 캡슐의제조는한국공개특허제 2016-0116827호에개시된캡슐제조장치를 이용하였다.위특허출원에는캡슐에포함되는코어로서향액이개시되어 있고, 캡슐막으로는막재가개시되어 있으나,본발명에서는상기표 1및표 2의 2020/175894 1»（：1^1{2020/002703
10 성분을이용하였다.또한,위특허줄원에는노즐을구비한캡점:제조장치로 캡슐을제조하여건조하고,추가로경화함으로써하드캡슐을제조하였으나,본 발명에서는건조단계나,추가경화단계를제외함으로써소프트캡슐로 제조하였다.제조된소프트캡슐은하드캡슐을식용으로하기에는외막이 단단했던것에비해서외막이부드럽기때문에식용하기에적절하였다.
62] 제조된캡슐은이음새가없는심리스（8681111688）형태의캡슐이었으며,
투명하였다（도 1참조）.제조된캡슐의크기는현미경（0切1^118 및
1'011]3\¾\¥ 81011 86）프로그램을이용하여즉정하였으며,캡슐의크기는 4 였다.
제조예 5.다중코팅된소형연질캡슐제조
소형연질캡슐코팅시사용된원료의배합비는하기와같다.
[표 3]
Figure imgf000012_0001
[66] 5-1.소형연질캡슐 1차코팅
[67] 1차코팅은코팅액을사용하고,유동층코팅방법으로수행하였다.
코팅액으로는제조예 2, 3에서제조한홍삼농축액,감초추출물분말을 사용하였다.홍삼농축액에감초추출물분말을녹여서사용하였다.씨드로는 49358
66666 제조예 4에서제조한소형연질캡슐을사용하였다.건조된소형연질캡슐,홍삼 농축액,감초추출물분말의비율은 5:4:0.5로하였다.제조예 2의홍삼농축액은 정제수를넣어당도를 45 로조정하였고,교반기로속도 55+5 RPM,온도 40±5ᄋ（:조건으로교반하여코팅액을준비하였다.코팅액이준비되면,캡슐을 유동층기기田（31 1 5-1, £01（¾.,!止1）에시드로투입후코팅기온도를 40°0 이하로조절하였다.코팅액을 2 /분양으로분사하였다.분사완료한후 40°0 이하에서 20분이상건조하였다.
5-2.소형연질캡슐 2차코팅
2차코팅은코팅물로사용하고유동층코팅방법으로수행하였다.코팅물로는 제조예 1에서제조한홍삼분말을사용하였고,씨드로는제조예 5에서제조한 1차코팅된소형연질캡슐을사용하였다. 1차코팅된소형연질캡슐과홍삼 분말의중량대비비율은 95:5로하였다.홍삼분말과정제수중량을 2:8의 비율로녹여서상부구동방식혼합기로균질화한뒤미량연속펌프를이용하여 유동층코팅기내부로노즐분사하였다. 2020/175894 1»（：1^1{2020/002703
11 이 1차코팅된소형연질캡슐을유동층기기에시드로투입후코팅기온도를
40°0이하로조절하였다.코팅액을細ᄊ분양으로분사하였다.분사완료한후 40°0이하에서 20분이상건조하였다.
1] 1차, 2차코팅하여제조된다중코팅된소형연질캡슐은갈색의환제형으로 홈,주름,무늬,갈라짐이없었고,고유의색택과향미를가지며,이미,이취가 없었다.또한다중코팅된소형연질캡슐의경도는 21 ^이상이었고,대장균군은 음성으로확인되었다.육안으로확인된다중코팅된소형연질캡슐을스틱 포장하여밀봉하였다.각스틱의중량편차（%）를확인하였다.중량편차가 5- 10%인것이 2개이하였다.
2] 실험예 1.다중코팅된소형연질캡슐의물성평가
3] 1-1.다중코팅된소형연질캡슐내액상원료의형태유지여부확인
4] 소형연질캡슐은하드캡슐에비해서외막이외부충격에의해서쉽게파괴될 수있어대기중에노출시보관이나,유통에어려움이 있었다.따라서,소형연질 캡슐내에포함된오일류,착향료와같은액상원료의형태를유지하면서도, 외부충격을상쇄할수있는코팅이필요하였다.따라서,본발명에서는 1차, 2차 코팅하여소형연질캡슐내부의원료의형태를유지할수있는지확인하였다.
1차코팅, 2차코팅된캡슐의내구성은경도를측정하여확인하였다.경도는
Figure imgf000013_0001
측정하였다. 1차코팅된캡슐의경도 측정결과를표 4에나타내고 , 2차코팅된캡슐（다중코팅된캡슐）의경도측정 결과를표 5에나타낸다.
5] [표 4]
Figure imgf000013_0002
[76] [표 5]
Figure imgf000013_0003
2020/175894 1»（：1^1{2020/002703
12
7] 1차코팅된캡슐은해당직경에서사람이저작할수있는일반적인경도인 11대 내지 51대의이내결과값인 2.41 ^로확인되었고,다중코팅된캡슐은코팅하지 않은소형연질캡슐또는 1차코팅된캡슐에비해서,경도가높아져외부 충격에도깨지는캡슐의비율이낮았고,이에따라오일류,착향료와같은액상 원료의형태가유지되었다.
8] 1-2.다중코팅된소형연질캡슐간접착정도평가
9] 1차, 2차코팅시에는유동층코팅방법을이용하였다.일반적으로유동층
과립품은강제열풍건조한상태로대기노출시수분이쉽게흡착되며과립간에 점성이생기고붙어덩어리가형성되어품질이급감하는현상이있다.
[8이 대조군은제조예 5에서홍삼농축액으로 1차코팅한소형연질캡슐을
사용하고,시험군은제조예 5에서홍삼농축액으로 1차코팅하고,홍삼분말로 2차코팅한소형연질캡슐을사용하였다.대조군와시험군을 3시간동안일반 실내조건인 25ᄋ（:, 50-60% 1111에노출시키고,노출시간별로코팅된캡슐간 접착하여덩어리지는정도를 ^메쉬체에통과시켜통과비율로평가하였다. 캡슐이덩어리질경우체를통과하지못하여통과비율이낮아지게된다.
대조군와시험군의 메쉬통과비율（%）을하기표 6에나타낸다.
[81] [표 6]
Figure imgf000014_0001
[82] 표 6에나타낸바와같이,시험군의경우캡슐간접착이적고 3시간후에도 메쉬체를통과하는캡슐이 100%였다（도 2및도 3참조）.반면에,대조군의 경우시간에비례하여코팅된캡슐간접착정도가심해져서 3시간째에는 ^메쉬 체를통과하는캡슐이없었다.
[83] 위결과를통해서 1차코팅된캡슐에홍삼분말코팅시비코팅캡슐보다대기 중수분흡착을효과적으로억제하여캡슐고유의형태를유지시켜품질이 우수해지는것을알수있었다.
[84]

Claims

2020/175894 1»（：1/10公020/002703
13
청구범위
［청구항 1］ 액상원료를포함하는연질캡슐;연질캡슐의표면에코팅되는홍삼
추출물로이루어진 1차코팅물;및 1차코팅물의표면에코팅되는홍삼 분말로이루어진 2차코팅물;로이루어진다중코팅된연질캡슐.
［청구항 2］ 청구항 1에있어서,
상기 액상원료는오일을포함하는다중코팅된연질캡슐.
［청구항 3］ 청구항 2에있어서,
상기 액상원료는착향료및지용성비타민중적어도하나를추가로 포함하는다중코팅된연질캡슐.
［청구항 4］ 청구항 1에있어서,
상기연질캡슐의직경은 1■내지 111111인다중코팅된연질캡슐.
［청구항 5］ 청구항 1에있어서,
상기연질캡슐의피막은글리세린,한천,펙틴,스테비올배당체및 알긴산나트륨을포함하는피막제가경화된것인다중코팅된연질캡슐. ［청구항 6］ 청구항 5에있어서,
상기피막제의점도는 3000?8내지 85吹?8인다중코팅된연질캡슐.
［청구항 7］ 청구항 1에있어서,
상기홍삼추출물은
Figure imgf000015_0001
캡슐.
［청구항 8］ 청구항 1에있어서,
상기홍삼추출물의진세노사이드 1 1, 111)1, 1¾3의합은 1 1¾ 내지 15 11¾ 인다중코팅된연질캡슐.
［청구항 9］ 청구항 1에있어서,
상기홍삼분말의입도는 120메쉬를통과하는분말이 60%이상인다중 코팅된연질캡슐.
［청구항 1이 청구항 1에있어서,
상기코팅은유동증기기를이용하여수행되는다중코팅된연질캡슐. ［청구항 11］ 청구항 1에있어서,
상기연질캡슐 50중량부에대해서,홍삼추출물은 20중량부내지 60 중량부,홍삼분말은 1내지 20중량부로포함되는다중코팅된연질캡슐. ［청구항 12］ 청구항 1에있어서,
상기 1차코팅물은식물주줄물을주가로포함하는다중코팅된연질 캡슐.
［청구항 13］ 청구항 1에있어서,
상기다중코팅된연질캡슐의경도는 0.51 ^내지 51대인다중코팅된 연질캡슐.
［청구항 14］ 액상원료를포함하는연질캡슐을제조하는단계 ;
상기연질캡슐의표면에홍삼주줄물로이루어진 1차코팅물을코팅하는 2020/175894 1»（：1^1{2020/002703
14 제 1코팅단계;및
상기 1차코팅물의표면에홍삼분말로이루어진 2차코팅물을코팅하는 제 2코팅단계;를포함하는다중코팅된연질캡슐의제조방법.
[청구항 15] 청구항 14에 있어서,
상기 제 1및제 2코팅은각각유동층기기를이용하여수행되는방법 .
PCT/KR2020/002703 2019-02-27 2020-02-25 다중 코팅된 연질 캡슐 WO2020175894A2 (ko)

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