WO2020173172A1 - 减肥片的组成及其制备方法 - Google Patents

减肥片的组成及其制备方法 Download PDF

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WO2020173172A1
WO2020173172A1 PCT/CN2019/124246 CN2019124246W WO2020173172A1 WO 2020173172 A1 WO2020173172 A1 WO 2020173172A1 CN 2019124246 W CN2019124246 W CN 2019124246W WO 2020173172 A1 WO2020173172 A1 WO 2020173172A1
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extract
slimming
tablet
take
powder
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高美雯
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高美雯
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Definitions

  • the invention relates to the field of weight loss. More specifically, the present invention relates to slimming tablets and preparation methods thereof.
  • Obesity has become a global health problem. Obesity not only affects the body's beauty, but also may cause diseases such as hypertension, diabetes, dyslipidemia, and coronary heart disease.
  • the methods to solve the obesity problem include diet therapy, exercise therapy, western medicine therapy, etc. Although these methods have certain effects, western medicine therapy has obvious side effects, and dieting and exercise require higher willpower. Therefore, it is urgent to design a weight-loss product that can overcome the above-mentioned shortcomings to a certain extent.
  • An object of the present invention is to provide a slimming tablet and a preparation method thereof.
  • the slimming tablet is made of a first pellet and a second pellet. After taking, the second pellet produces an effect quickly, and the first pellet slowly exerts its effect. The two coordinate effects to improve the weight loss effect.
  • the weight loss tablets do not contain western medicines with side effects.
  • a slimming tablet which includes the following ingredients by weight:
  • the weight loss tablet contains 0.2 grams of selenium per 100 grams of selenium-enriched yeast.
  • the slimming tablet further includes:
  • the invention also provides a preparation method of the slimming tablet, which includes:
  • Step 1 Crush the mulberries, pass a 20-mesh sieve, and extract 3 times with 50°C water, combine the extracts, concentrate the filtrate into a paste at 60°C, and dry the paste at 60°C under vacuum to obtain mulberries Extract;
  • Step 2 The extraction residue obtained in step 1 is beaten, mixed with corn, steamed, and fermented with yeast, and the fermentation broth is distilled to obtain mulberry wine;
  • Step 3 Take the corn silk, soak it in water for 5 minutes, then put it in an oven at 300°C for 2 seconds, take it out, soak the mulberry wine obtained in step 2 for 8 hours, filter, take the filtrate, and spray dry to obtain the corn silk extract ;
  • Step 4 Take the fragrant tea vegetable with narrow line pattern, chop it, extract with the mulberry wine obtained in step 2, take the filtrate, and spray dry to obtain the extract of fragrant tea vegetable with narrow line pattern;
  • Step 5 Take the clam meat, freeze-dry it, soak it in mulberry wine for 2 hours, take it out, freeze-dry it again, and crush to obtain the primary powder. Put the primary powder into the filter bag and soak it with citric acid solution and mulberry wine for 2 hours and Disperse the primary powder in water for 1 hour, add papain for enzymatic hydrolysis for 4 hours, add 0.1 times the volume of mulberry wine to the enzymatic hydrolysate, and spray dry to obtain mussel meat powder;
  • Step 6 Take a part of konjac flour, white kidney bean extract, narrow-line-grained tea vegetable extract and mussel meat powder, mix it with a binder, and place it in an extrusion spheronization granulator to obtain the first pellets.
  • the first pellet is externally coated with a slow-release coating;
  • Step 7 mixing the first pellet and the second pellet obtained in step 6, and compressing the tablet to obtain a slimming tablet.
  • the quality of the corn is 0.2 times the quality of the mulberry in step 1, and the alcohol content of the obtained mulberry wine is 30 degrees.
  • the preparation method of the slimming tablet in the preparation method of the slimming tablet, in the process of soaking with citric acid solution and mulberry wine, irradiating with ultrasonic for 10 minutes every 10 minutes.
  • the mass ratio of the konjac flour used to manufacture the first pellet and the second pellet is 1:2.
  • the preparation method of the slimming tablet and the preparation method of the grapefruit peel powder include: cutting the grapefruit peel into flakes, drying to constant weight at 90°C, and crushing.
  • the invention does not contain western medicine, has no or little side effects, and is suitable for long-term administration.
  • the second pellets act quickly.
  • Konjac powder makes people feel full, reduces appetite, and promotes fat metabolism.
  • the first pellets are released slowly so that people can maintain satiety for a long time.
  • the absorption of carbohydrates is continuously reduced.
  • the coordination effect of the first pellet and the second pellet effectively improves the weight loss effect.
  • the grapefruit peel powder is made by drying and pulverizing, as an adsorbent, so that the raw materials can be adsorbed more uniformly Around the grapefruit peel powder, it is evenly dispersed in the slimming tablet, so that the effect of the present invention is more even, and the slimming effect is further improved.
  • mulberry wine is used to extract corn silk extract and narrow-line pattern coriander extract, and to assist in preparing mussel meat powder, which improves the utilization of raw materials, and compared with conventional water extraction, corn silk extract is more conducive to weight loss.
  • corn silk extract is more conducive to weight loss.
  • the fishy taste of the mussel meat is lower, and the beneficial substances in the mulberries also penetrate into the corn silk extract and the mussel meat powder.
  • the weight loss tablet contains 0.2 grams of selenium per 100 grams of selenium-enriched yeast.
  • the corn silk extract, the mulberry extract, and the narrow-line pattern coriander extract are prepared by the water extraction method.
  • Mussel meat powder is prepared by freeze-drying and crushing.
  • the preparation method of the slimming tablet includes: taking the above-mentioned raw materials, mixing in microcrystalline cellulose, sodium starch glycolate and magnesium stearate, and compressing into the slimming tablet.
  • the preparation method of slimming tablets includes:
  • Step 1 Crush the mulberries, pass a 20-mesh sieve, and extract 3 times with 50°C water, combine the extracts, concentrate the filtrate into a paste at 60°C, and dry the paste at 60°C under vacuum to obtain mulberries Extract;
  • Step 2 The extraction residue obtained in step 1 is beaten, that is, the filter residue produced in the process of extracting mulberries is mixed with corn, steamed, connected to yeast for fermentation, and the fermentation broth is distilled to obtain mulberry wine;
  • Step 3 Take the corn silk, soak it in water for 5 minutes, then put it in an oven at 300°C for 2 seconds, take it out, soak the mulberry wine obtained in step 2 for 8 hours, filter, take the filtrate, and spray dry to obtain the corn silk extract ;
  • Step 4 Take the narrow-line pattern fragrant tea vegetable, chop it, extract with the mulberry wine obtained in step 2, take the filtrate, and spray dry to obtain the narrow-line pattern fragrant tea vegetable extract;
  • Step 5 Take the clam meat, freeze-dry it, soak it in mulberry wine for 2 hours, take it out, freeze-dry it again, and crush to obtain the primary powder. Put the primary powder into the filter bag and soak it with citric acid solution and mulberry wine for 2 hours and Disperse the primary powder in water for 1 hour, add papain for enzymatic hydrolysis for 4 hours, add 0.1 times the volume of mulberry wine to the enzymatic hydrolysate, and spray dry to obtain mussel meat powder;
  • Step 6 Take a part of the konjac flour, white kidney bean extract, narrow-line scented tea vegetable extract and mussel meat powder, mix it with the binder, and place it in the extrusion spheronization granulator to obtain the first pellet, and take the shell Glycan, selenium-enriched yeast, tea polyphenols, mulberry extract, corn silk extract, grapefruit peel powder and another part of konjac powder, mixed with the binder, and the second pellet is obtained by the extrusion spheronization granulation mechanism, with ethyl
  • the cellulose dispersion is coated with a sustained-release coating on the outside of the first pellet;
  • Step 7 mixing the first pellet and the second pellet obtained in step 6, and compressing the tablet to obtain a slimming tablet.
  • the quality of the corn is 0.2 times the quality of the mulberry in step 1, and the alcohol content of the obtained mulberry wine is 30 degrees.
  • the mass ratio of the konjac powder used for manufacturing the first pellet and the second pellet is 1:2.
  • the preparation method of the slimming tablet and the preparation method of the grapefruit peel powder include: cutting the grapefruit peel into flakes, drying to constant weight at 90°C, and crushing.
  • the rats were fed with high-fat diet, weighed once a week, and fed continuously for 6 weeks. From the rats fed with high-fat diet, 60 rats with a weight difference within 5% were selected and randomly divided into three groups with 20 rats in each group. Among them, the two groups of rats were intragastrically administered respectively.
  • the control group was given intragastric sodium chloride solution.
  • the rats were anesthetized, and the rats were killed by carbon dioxide inhalation, and the epididymis, perirenal and mesenteric adipose tissues were excised and weighed. See Table 3.
  • Example 1 and Example 2 slow down the weight gain of rats, and because Example 2 uses a new preparation compared with Example 1. The technology makes the rat's weight gain lower.
  • Example 1 Sixty subjects over the standard body weight were randomly selected and randomly divided into three groups. During the period, the two groups took the weight-loss tablets obtained in Example 1 and Example 2 respectively, and the other group served as a control group and took a placebo. Take 12 grams a day for two consecutive months to test the weight, body fat, and body fat percentage of the subjects. The results are shown in Table 4, Table 5 and Table 6.
  • Example 1 and Example 2 both show significant weight loss effects on the subjects, while Example 2 corresponds to Example 1 due to the adoption of a new preparation process, and the weight loss effect is certain. The degree is improved.
  • the blood routine, blood biochemical indexes, uric acid, and heart rate of 60 subjects were tested before and after the experiment. The results showed that all the indexes were within the normal range. The subject stated that there was no abnormal reaction after taking the slimming tablet of the present invention.

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Abstract

一种中药片剂及其制备方法。所述片剂由包括以下的原料制成：魔芋粉、壳聚糖、白芸豆提取物、富硒酵母、茶多酚、玉米须提取物、桑葚提取物、蚌肉粉、狭基线纹香茶菜提取物、柚子皮粉。所述中药片剂用于减肥。

Description

减肥片的组成及其制备方法 技术领域
本发明涉及减肥相关领域。更具体地说，本发明涉及减肥片及其制备方法。
背景技术
肥胖已成为全球性的健康问题，肥胖不仅影响形体美感，而且可能带来高血压病、糖尿病、血脂紊乱、冠心病等疾病。目前，解决肥胖问题的方法包括节食疗法、锻炼疗法、西药疗法等。这些方法虽然均有一定的效果，但是西药疗法具有明显的副作用，而节食和锻炼对人的意志力要求较高。因此，亟需设计一种能够一定程度克服上述缺陷的减肥产品。
发明内容
本发明的一个目的是提供一种减肥片及其制备方法，该减肥片由第一微丸和第二微丸制成，服用后，第二微丸迅速产生效果，第一微丸缓慢发挥作用，两者协调作用，提高了减肥效果，减肥片中不包含有副作用的西药。
为了实现根据本发明的这些目的和其它优点，提供了减肥片，包括以下重量份的原料：
魔芋粉2份、壳聚糖1.5份、白芸豆提取物1.2份、富硒酵母0.035份、茶多酚0.3份。
优选的是，所述的减肥片，每100克富硒酵母中硒含量为0.2克。
优选的是，所述的减肥片，还包括：
玉米须提取物0.5份、桑葚提取物0.1份、蚌肉粉0.2份、狭基线纹香茶菜提取物0.1份、柚子皮粉0.2份。
本发明还提供了减肥片的制备方法，包括：
步骤一、将桑葚粉碎，过20目筛，用50℃的水提取3次，合并提取液，将滤液在60℃下浓缩为膏状物，将膏状物在60℃下真空干燥，得到桑葚提取物；
步骤二、将步骤一得到的提取残渣打浆，混入玉米，蒸熟，接入酵母菌进行发酵，蒸馏发酵液，得到桑葚酒；
步骤三、取玉米须，用水浸泡5分钟，然后放入300℃的烘箱中停留2秒，取出，用步骤二得到的桑葚酒浸泡8小时，过滤，取滤液，喷雾干燥，得玉米须提取物；
步骤四、取狭基线纹香茶菜，切碎，用步骤二得到的桑葚酒提取，取滤液，喷雾干燥， 得狭基线纹香茶菜提取物；
步骤五、取蚌肉，冻干，用桑葚酒浸泡2小时，取出并再次冻干，粉碎，得到初级粉末，将初级粉末装入滤袋中，分别用柠檬酸溶液和桑葚酒浸泡2小时和1小时，将初级粉末分散在水中，加入木瓜蛋白酶，酶解4小时，向酶解液中加入0.1倍体积的桑葚酒，喷雾干燥，得到蚌肉粉；
步骤六、取一部分魔芋粉、白芸豆提取物、狭基线纹香茶菜提取物和蚌肉粉，混入粘合剂，置入挤出滚圆造粒机中，制得第一微丸，取壳聚糖、富硒酵母、茶多酚、桑葚提取物、玉米须提取物、柚子皮粉及另一部分魔芋粉，混合均匀，加入粘合剂，用挤出滚圆造粒机制得第二微丸，在第一微丸外部包缓释包衣；
步骤七、将步骤六得到的第一微丸和第二微丸混合，压片，得到减肥片。
优选的是，所述的减肥片的制备方法，玉米的质量为步骤一中桑葚质量的0.2倍，得到的桑葚酒的酒精度为30度。
优选的是，所述的减肥片的制备方法，在用柠檬酸溶液和桑葚酒浸泡过程中，每隔10分钟，用超声波辐照10分钟。
优选的是，所述的减肥片的制备方法，用于制造第一微丸和第二微丸的魔芋粉的质量比为1:2。
优选的是，所述的减肥片的制备方法，柚子皮粉的制备方法包括：将柚子皮切成片状，在90℃条件下干燥至恒重，粉碎。
本发明至少包括以下有益效果：
本发明不含西药，副作用无或小，适合长期服用。本发明在被服用后，第二微丸迅速作用，魔芋粉使得人快速产生饱腹感，降低食欲，并促进脂肪的代谢，第一微丸缓慢释放，使得人较长时间维持饱腹感，并且持续减少人对碳水化合物的吸收，第一微丸和第二微丸的协调作用，有效提高了减肥效果，柚子皮粉通过干燥、粉碎制得，作为吸附剂，使得各原料可以较均匀地吸附在柚子皮粉周围，进而均匀分散在减肥片中，使得本发明的作用更加均匀，进一步提高减肥效果。本发明利用桑葚酒提取玉米须提取物和狭基线纹香茶菜提取物，并辅助制备蚌肉粉，提高了原料利用率，并且相比于常规水提，玉米须提取物更有利于减肥，相比于常规蚌肉粉的制备方法，蚌肉的腥味低，并且桑葚中的有益物质也渗入玉米须提取物和蚌肉粉中。
本发明的其它优点、目标和特征将部分通过下面的说明体现，部分还将通过对本发明的研究和实践而为本领域的技术人员所理解。
具体实施方式
下面结合实施例对本发明做进一步的详细说明，以令本领域技术人员参照说明书文字能够据以实施。
实施例1：
减肥片，包括以下重量份的原料：
魔芋粉2份、壳聚糖1.5份、白芸豆提取物1.2份、富硒酵母0.035份、茶多酚0.3份、玉米须提取物0.5份、桑葚提取物0.1份、蚌肉粉0.2份、狭基线纹香茶菜提取物0.1份、柚子皮粉0.2份。
所述的减肥片，每100克富硒酵母中硒含量为0.2克。
玉米须提取物、桑葚提取物和狭基线纹香茶菜提取物通过水提方法制取。蚌肉粉通过冻干、粉碎制得。
减肥片的制备方法，包括：取上述原料，混入微晶纤维素、羧甲淀粉钠和硬脂酸镁，压制为减肥片。
实施例2：
减肥片，包括以下重量份的原料：
魔芋粉2份、壳聚糖1.5份、白芸豆提取物1.2份、富硒酵母0.035份、茶多酚0.3份、玉米须提取物0.5份、桑葚提取物0.1份、蚌肉粉0.2份、狭基线纹香茶菜提取物0.1份、柚子皮粉0.2份。
减肥片的制备方法，包括：
步骤一、将桑葚粉碎，过20目筛，用50℃的水提取3次，合并提取液，将滤液在60℃下浓缩为膏状物，将膏状物在60℃下真空干燥，得到桑葚提取物；
步骤二、将步骤一得到的提取残渣打浆，即对桑葚进行提取过程中产生的滤渣，混入玉米，蒸熟，接入酵母菌进行发酵，蒸馏发酵液，得到桑葚酒；
步骤三、取玉米须，用水浸泡5分钟，然后放入300℃的烘箱中停留2秒，取出，用 步骤二得到的桑葚酒浸泡8小时，过滤，取滤液，喷雾干燥，得玉米须提取物；
步骤四、取狭基线纹香茶菜，切碎，用步骤二得到的桑葚酒提取，取滤液，喷雾干燥，得狭基线纹香茶菜提取物；
步骤五、取蚌肉，冻干，用桑葚酒浸泡2小时，取出并再次冻干，粉碎，得到初级粉末，将初级粉末装入滤袋中，分别用柠檬酸溶液和桑葚酒浸泡2小时和1小时，将初级粉末分散在水中，加入木瓜蛋白酶，酶解4小时，向酶解液中加入0.1倍体积的桑葚酒，喷雾干燥，得到蚌肉粉；
步骤六、取一部分的魔芋粉、白芸豆提取物、狭基线纹香茶菜提取物和蚌肉粉，混入粘合剂，置入挤出滚圆造粒机中，制得第一微丸，取壳聚糖、富硒酵母、茶多酚、桑葚提取物、玉米须提取物、柚子皮粉及另一部分魔芋粉，混入粘合剂，用挤出滚圆造粒机制得第二微丸，用乙基纤维素分散体在第一微丸外部包缓释包衣；
步骤七、将步骤六得到的第一微丸和第二微丸混合，压片，得到减肥片。
所述的减肥片的制备方法，玉米的质量为步骤一中桑葚质量的0.2倍，得到的桑葚酒的酒精度为30度。
所述的减肥片的制备方法，在用柠檬酸溶液和桑葚酒浸泡过程中，每隔10分钟，用超声波辐照10分钟。
所述的减肥片的制备方法，用于制造第一微丸和第二微丸的魔芋粉的质量比为1:2。
所述的减肥片的制备方法，柚子皮粉的制备方法包括：将柚子皮切成片状，在90℃条件下干燥至恒重，粉碎。
试验1：
将大鼠分用高脂饲料喂养，每周称重1次，连续喂养6周。从使用高脂饲料喂养的大鼠中选取体重相差在5％以内的60只大鼠，随机分为三组，每组20只，其中，两组大鼠分别灌胃实施例1、实施例2的减肥片(100毫克/kg)，另外一组作为对照组灌胃氯化钠溶液，每组大鼠均每天灌胃一次，三组大鼠继续用高脂饲料喂养，记录大鼠每天的体重和摄食量，计算各组大鼠在0天、7天、14天和21天的体重均值和摄食量均值(g)，进行t检验，结果见表1和表2，单位克。对照组灌胃氯化钠溶液。在试验结尾，将大鼠麻醉，用二氧化碳吸入法杀死大鼠，切除附睾、肾周和肠系膜脂肪组织并称重，见表3。
表1
平均体重(g) 第0天 第7天 第14天 第21天
实施例1 420.3±11.5 429.1±11.3* 437.8±9.2* 444.5±10.1*
实施例2 420.3±10.7 427.1±8.3* 432.5±11.1* 438.3±8.7*
对照组 419.8±11.4 430.9±9.9 439.5±10.2 450.4±9.4
与对照组相比，差异性显著，*P小于0.05。
表2
平均摄食量(g) 第一个7天 第二个7天 第三个7天
实施例1 25.1±2.3* 24.8±1.5* 25.5±2.0*
实施例2 23.1±1.3* 23.5±2.1* 23.3±1.7*
对照组 26.9±1.9 26.1±2.2 26.6±1.8
与对照组相比，差异性显著，*P小于0.05。
表3
Figure PCTCN2019124246-appb-000001
与对照组相比，差异性显著，*P小于0.05。
由表1、表2和表3可知，与对照组相比，实施例1、实施例2使得大鼠的体重增长速度放缓，而由于实施例2相比于实施例1采用了新的制备工艺，使得大鼠的体重增长速度更低。
试验2：
随机选择60名超过标准体重的受试者，随机分为三组，期中，两组分别服用实施例1、实施例2得到的减肥片，另一组作为对照组，服用安慰剂。每天服用12克，连续服用两个月，检测受试者的体重、体脂以及体脂百分率，结果见表4、表5和表6。
表4
  初始平均体重(kg) 两个月后平均体重(kg)
实施例1 75.3 73.8
实施例2 77.2 72.3
对照组 77.1 78.2
表5
  初始体脂(kg) 两个月后体脂(kg)
实施例1 24.6 21.8
实施例2 25.5 20.2
对照组 25.3 25.7
表6
  初始体脂百分率(％) 两个月后体脂百分率(％)
实施例1 31.9 31.3
实施例2 32.2 30.1
对照组 32.2 32.3
可以看出，相比于对照组，实施例1、实施例2均显示出了对受试者明显的减肥效果，而实施例2相对应实施例1由于采用了新的制备工艺，减肥效果一定程度提高。
安全性测试：
实验前后对60名受试者的血常规、血液生化各项指标、尿酸、心率进行检测，结果显示各项指标均在正常值范围内。受试者自述食用本发明的减肥片无异常反应。
尽管本发明的实施方案已公开如上，但其并不仅仅限于说明书和实施方式中所列运用，它完全可以被适用于各种适合本发明的领域，对于熟悉本领域的人员而言，可容易地实现另外的修改，因此在不背离权利要求及等同范围所限定的一般概念下，本发明并不限于特定的细节和这里示出与描述的实施例。

Claims (8)

  1. 减肥片，其特征在于，包括以下重量份的原料：
    魔芋粉2份、壳聚糖1.5份、白芸豆提取物1.2份、富硒酵母0.035份、茶多酚0.3份。
  2. 如权利要求1所述的减肥片，其特征在于，每100克富硒酵母中硒含量为0.2克。
  3. 如权利要求1所述的减肥片，其特征在于，还包括：
    玉米须提取物0.5份、桑葚提取物0.1份、蚌肉粉0.2份、狭基线纹香茶菜提取物0.1份、柚子皮粉0.2份。
  4. 减肥片的制备方法，其特征在于，包括：
    步骤一、将桑葚粉碎，过20目筛，用50℃的水提取3次，合并提取液，将滤液在60℃下浓缩为膏状物，将膏状物在60℃下真空干燥，得到桑葚提取物；
    步骤二、将步骤一得到的提取残渣打浆，混入玉米，蒸熟，接入酵母菌进行发酵，蒸馏发酵液，得到桑葚酒；
    步骤三、取玉米须，用水浸泡5分钟，然后放入300℃的烘箱中停留2秒，取出，用步骤二得到的桑葚酒浸泡8小时，过滤，取滤液，喷雾干燥，得玉米须提取物；
    步骤四、取狭基线纹香茶菜，切碎，用步骤二得到的桑葚酒提取，取滤液，喷雾干燥，得狭基线纹香茶菜提取物；
    步骤五、取蚌肉，冻干，用桑葚酒浸泡2小时，取出并再次冻干，粉碎，得到初级粉末，将初级粉末装入滤袋中，分别用柠檬酸溶液和桑葚酒浸泡2小时和1小时，将初级粉末分散在水中，加入木瓜蛋白酶，酶解4小时，向酶解液中加入0.1倍体积的桑葚酒，喷雾干燥，得到蚌肉粉；
    步骤六、取一部分魔芋粉、白芸豆提取物、狭基线纹香茶菜提取物和蚌肉粉，混入粘合剂，置入挤出滚圆造粒机中，制得第一微丸，取壳聚糖、富硒酵母、茶多酚、桑葚提取物、玉米须提取物、柚子皮粉及另一部分魔芋粉，混合均匀，加入粘合剂，用挤出滚圆造粒机制得第二微丸，在第一微丸外部包缓释包衣；
    步骤七、将步骤六得到的第一微丸和第二微丸混合，压片，得到减肥片。
  5. 如权利要求1所述的减肥片的制备方法，其特征在于，玉米的质量为步骤一中桑 葚质量的0.2倍，得到的桑葚酒的酒精度为30度。
  6. 如权利要求1所述的减肥片的制备方法，其特征在于，在用柠檬酸溶液和桑葚酒浸泡过程中，每隔10分钟，用超声波辐照10分钟。
  7. 如权利要求1所述的减肥片的制备方法，其特征在于，用于制造第一微丸和第二微丸的魔芋粉的质量比为1:2。
  8. 如权利要求1所述的减肥片的制备方法，其特征在于，柚子皮粉的制备方法包括：将柚子皮切成片状，在90℃条件下干燥至恒重，粉碎。
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