WO2020164511A1 - Machine d'unité de dissolution et d'administration de médicament - Google Patents

Machine d'unité de dissolution et d'administration de médicament Download PDF

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Publication number
WO2020164511A1
WO2020164511A1 PCT/CN2020/074858 CN2020074858W WO2020164511A1 WO 2020164511 A1 WO2020164511 A1 WO 2020164511A1 CN 2020074858 W CN2020074858 W CN 2020074858W WO 2020164511 A1 WO2020164511 A1 WO 2020164511A1
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WO
WIPO (PCT)
Prior art keywords
dissolving
dispensing
drive
medicine
movement mechanism
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Application number
PCT/CN2020/074858
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English (en)
Chinese (zh)
Inventor
刘伟强
陈煊
赵罗瑞斯
Original Assignee
上海螭宿医药科技有限公司
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Application filed by 上海螭宿医药科技有限公司 filed Critical 上海螭宿医药科技有限公司
Publication of WO2020164511A1 publication Critical patent/WO2020164511A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe

Definitions

  • the embodiments of the present application relate to, but are not limited to, the field of dissolving and dispensing devices, and in particular to a dissolving and dispensing unit machine for automatic dissolution and dispensing.
  • Puncture the rubber stopper of the vial and infusion container for many times which is easy to cause the drug to splash and volatilize, causing trace long-term damage to the dispensing personnel, and may bring irreversible consequences; multiple piercing of the rubber stopper of the vial and infusion container is due to the needle When exposed to a non-sterile environment, microbes can contaminate the needle, and the contaminated microbes may cause secondary contamination with multiple punctures; in addition, some drugs are more difficult to dissolve, and conventional dissolution methods take longer to dissolve, and some drugs require special solvents. Dissolve, and then perform dissolving and dispensing operations. Moreover, manual operation is susceptible to the mental state of the operator and the speed of dispensing. Therefore, medical institutions need to innovate the dispensing method, which has been automated, efficient, and pollution-free.
  • a dissolving and dispensing unit machine includes:
  • the dissolving and dispensing device is installed on the main substrate and includes a dissolving and dispensing device and a peristaltic pump.
  • the dissolving and dispensing device includes at least one dissolving and dispensing channel, and each of the dissolving and dispensing channels includes two punctures and connecting the two The elastic infusion hose of the trocar, the peristaltic pump is arranged to squeeze the elastic infusion hose;
  • Two fixing modules are installed on the main substrate and configured to fix the medicine container, the dissolving and dispensing device is located above, and the two fixing modules are located below; or, the two fixing modules are located above, the The dissolving and dispensing device is located below;
  • the horizontal movement mechanism is configured to drive the medicine dissolving and dispensing device to move in a horizontal plane, so that the two piercers of the medicine dissolving and dispensing device correspond longitudinally with the two medicine containers fixed on at least one of the fixing modules;
  • the longitudinal movement mechanism is configured to drive one of the two fixing modules and the medicine dissolving device to move longitudinally, so that the piercing device pierces the medicine container or is separated from the medicine container.
  • the dissolving and dispensing device further includes a sub-substrate, the dissolving and dispensing device and the peristaltic pump are both mounted on the sub-substrate, the sub-substrate is movably connected to the main substrate, and the The horizontal movement mechanism is arranged to drive the auxiliary substrate to move.
  • the horizontal movement mechanism is a linear movement mechanism configured to drive the auxiliary substrate to move linearly.
  • the horizontal movement mechanism includes a transverse rail, a transverse slider, and a transverse drive module.
  • the transverse drive module and the transverse rail are mounted on the main substrate, and the transverse slider is connected to the The horizontal rail is matched, the horizontal slider is connected with the auxiliary substrate, and the horizontal driving module is configured to drive the horizontal slider to move along the horizontal rail.
  • the horizontal movement mechanism is a horizontal rotation mechanism configured to drive the auxiliary substrate to perform a horizontal rotation movement in a horizontal plane.
  • one fixing module includes a plurality of fixing units, each fixing unit is configured to fix one medicine container, and the horizontal movement mechanism is configured to drive the medicine dissolving and dispensing device to move horizontally until The two piercers of the dissolving and dispensing channel are longitudinally corresponding to the two fixing units one by one.
  • the fixing module further includes a fixing frame and a linear drive device, a plurality of the fixing units are fixed on the fixing frame and arranged linearly, and the linear drive device is configured to drive the fixing frame Linear movement.
  • the fixing module further includes a fixing frame and a rotation driving device, a plurality of the fixing units are fixed on the fixing frame and arranged in a circle, and the rotation driving device is configured to drive the fixing frame Rotational movement.
  • the linear drive device or the rotary drive device of the fixed module is wrapped by a sealing cover.
  • the longitudinal motion mechanism is configured to drive the two fixed modules to move longitudinally, the two fixed modules are located on the front side of the main substrate, and the longitudinal motion mechanism is located on the main substrate.
  • the longitudinal movement mechanism is connected to the two fixed modules through a supporting frame, a longitudinal sliding groove is provided on the main base plate, and the supporting frame passes through the longitudinal sliding groove;
  • a first hood is fixed on the rear side of the main substrate, and the first hood covers the longitudinal movement mechanism.
  • the longitudinal motion mechanism includes a first longitudinal motion mechanism and a second longitudinal motion mechanism
  • the support frame includes a first support frame and a second support frame
  • the longitudinal slide groove includes a first longitudinal motion mechanism. Groove and a second longitudinal sliding groove
  • the first longitudinal motion mechanism is connected to the first of the two fixed modules through the first supporting frame, and the first supporting frame passes through the first longitudinal direction A sliding groove
  • the second longitudinal movement mechanism is connected to a second fixed module of the two fixed modules through the second supporting frame, and the second supporting frame passes through the second longitudinal sliding groove.
  • the dissolving and dispensing device is located above the two fixed modules, and the horizontal movement mechanism is located on the rear side of the main substrate and above the longitudinal movement mechanism;
  • the first hood covers the horizontal movement mechanism, an upper part of the first hood is provided with a mounting groove, and the auxiliary base plate is connected to the horizontal movement mechanism after passing through the mounting groove.
  • a second hood is fixed on the secondary substrate, and the second hood covers the dissolving and dispensing device.
  • the dissolving and dispensing unit machine further includes a base and a rotating motor, the main substrate is rotatably connected to the base, and the rotating motor is configured to drive the main substrate to rotate relative to the base .
  • Fig. 1 is a three-dimensional schematic diagram of the front structure of a medicine dissolving and dispensing unit machine according to an embodiment of the present application;
  • FIG. 2 is a perspective schematic diagram of the rear view structure of the dissolving and dispensing unit machine according to an embodiment of the present application without the first cover and the second cover;
  • FIG. 3 is a schematic front view of the dissolving and dispensing unit machine according to an embodiment of the present application with the first cover and the second cover omitted;
  • FIG. 4 is a schematic structural diagram of a medicine dissolving and dispensing device in a medicine dissolving and dispensing unit machine according to an embodiment of the present application;
  • Fig. 5 is a schematic diagram of a three-dimensional structure of a medicine dissolving and dispensing unit machine according to an embodiment of the present application.
  • an embodiment of the present application provides a medicine dissolving and dispensing unit machine, which includes a main substrate 5, a medicine dissolving and dispensing device, two fixed modules, a horizontal movement mechanism and a longitudinal movement mechanism.
  • the dissolving and dispensing device is installed on the main substrate 5 and includes a dissolving and dispensing device 10 and a peristaltic pump.
  • the dissolving and dispensing device 10 includes at least one dissolving and dispensing channel, and each dissolving and dispensing channel includes two punctures and an elastic infusion hose connecting the two punctures.
  • the peristaltic pump is configured to squeeze the elastic infusion hose.
  • Two fixed modules are installed on the main base plate 5 and configured to fix the medicine container.
  • One of the dissolving and dispensing device and the two fixed modules is located above and the other is located below, that is, the dissolving and dispensing device is located above and the two fixed modules are located below; or, the two fixing modules are located above and the dissolving and dispensing device is located below.
  • the horizontal movement mechanism is arranged to drive the dissolving and dispensing device to move in the horizontal plane, so that the two piercers of the dissolving and dispensing device are longitudinally corresponding to the two medicine containers fixed on at least one fixed module, so that the dissolving and dispensing device or the fixed module moves longitudinally.
  • One piercing device can pierce two medicine containers respectively.
  • the longitudinal movement mechanism is arranged to drive one of the two fixed modules and the medicine dissolving device to move longitudinally, so that the piercer can pierce the medicine container or be separated from the medicine container.
  • the dissolving and dispensing device is set to puncture two medicinal containers that need to be dissolved and dispensed, and connect the two medicinal containers so that the contents of the two medicinal containers flow and mix with each other ,
  • the pump head of the peristaltic pump is set to squeeze the elastic infusion hose of the dissolving and dispensing device to drive the fluid flow in the elastic infusion hose to provide continuous power for the process of dissolving and dispensing
  • two fixed modules are installed on the main substrate The upper part is set to fix the medicine container;
  • the horizontal movement mechanism drives the dissolving and dispensing device to perform horizontal displacement, so that the vertical position of the puncture of the dissolving and dispensing device corresponds to the longitudinal direction of the fixed module;
  • the longitudinal movement mechanism drives the fixed module or drives the longitudinal movement of the dissolving and dispensing device, Move the fixed module and the puncture base toward each other so that the medicine container on the fixed module is punctured by the
  • the dissolving and dispensing unit machine provided in this embodiment does not need to repeatedly insert and extract the puncture during the dissolving and dispensing process, and can realize a fully enclosed dissolving and dispensing process, which not only reduces the labor intensity of dispensing, but also realizes automatic dispensing and improves efficiency. In addition, leakage and damage to dispensing personnel caused by leakage are avoided, and particulate pollution and secondary pollution by microorganisms are reduced or avoided.
  • the dissolving and dispensing unit machine of this embodiment is convenient to realize automatic, high-efficiency, and pollution-free dispensing.
  • the main substrate 5 may be connected to the base 1 and can be rotated relative to the base 1 under the driving of the rotating motor 31.
  • the dissolving and dispensing device may be installed on the main substrate 5 and may include the dissolving and dispensing device 10 and a peristaltic pump.
  • the dissolving and dispensing device 10 may include at least one dissolving and dispensing channel and two puncture bases 41, 42, each of the dissolving and dispensing channels may include two punctures 41, 42 and connecting two punctures.
  • the two punctures of each dissolving and dispensing channel can be installed on the two puncture bases 41, 42 respectively. In the example shown in FIG.
  • the dissolving and dispensing device 10 may include two dissolving and dispensing channels, and the two dissolving and dispensing channels may include two trocars mounted on the trocar base 41 (only shown in the figure One puncture 45), two punctures mounted on the puncture base 42 (only one of the punctures 46 is shown in the figure), and two elastic infusion hoses 43, 44 (the elastic infusion hose 43 can be Connect the piercers 45 and 46).
  • dissolving and dispensing device 10 The structure and working principle of the dissolving and dispensing device 10 are not described in detail in this application, and can refer to the Chinese patent application filed by the applicant named "Dissolving and Dispensing Device" and the application number is CN201820906668.6.
  • the peristaltic pump may include a peristaltic pump pump head and a pump head driving device.
  • the pump head driving device is configured to drive the pump head of the peristaltic pump to move to squeeze the elastic infusion hose.
  • the peristaltic pump may include two peristaltic pump heads 35, 36, and the pump head driving device may include an inner shaft 47, an outer shaft 48, an outer shaft rotation drive motor 33, and an inner shaft rotation Drive motor 34.
  • the two peristaltic pump heads 35, 36 can be arranged side by side, coaxial; the inner shaft 47 can be connected with a peristaltic pump head 36, the rotation of the inner shaft 47 can drive the connected peristaltic pump head 36 to rotate, and the outer shaft 48 can be connected to another peristaltic pump head 35.
  • the rotation of the outer shaft 48 can drive the connected peristaltic pump head 35 to rotate;
  • the inner shaft rotation drive motor 34 can be connected to the inner shaft 47, and the inner shaft rotation drive motor 34 can drive the inner shaft.
  • the shaft 47 rotates to drive the peristaltic pump head 36 connected to the inner shaft 47 to rotate;
  • the outer shaft rotation drive motor 33 can be connected to the outer shaft 48, and the outer shaft rotation drive motor 33 can drive the outer shaft 48 to rotate, thereby driving the outer shaft 48
  • the connected peristaltic pump head 35 rotates.
  • the types of the outer shaft rotation driving motor 33 and the inner shaft rotation driving motor 34 are not limited.
  • the outer shaft rotation driving motor 33 may be a hollow shaft motor, and the inner shaft 47 may pass through the outer shaft rotation driving motor 33 and the inner shaft rotation driving motor 34 When connected, the inner shaft rotation drives the motor 34 to rotate, thereby driving the peristaltic pump head 36 connected to the inner shaft 47 to rotate.
  • the inner shaft 47 and the outer shaft 48 can be arranged coaxially, and a bearing set or a roller set can be arranged between the inner shaft 47 and the outer shaft 48, so that the rotation of the inner shaft 47 and the outer shaft 48 does not affect each other.
  • the inner shaft rotation driving motor 34 and the outer shaft rotation driving motor 33 can be selected as stepping motors, so that when dissolving and dispensing liquid medicine, the medicine can be accurately sucked to realize quantitative dispensing.
  • At least one pump head of the peristaltic pump may be provided, which is configured to squeeze the elastic infusion hose of the dissolving and dispensing device 10 to drive the fluid flow in the elastic infusion hose to provide continuous power for the dissolution and dispensing process.
  • the peristaltic pump may include two peristaltic pump heads 35, 36, and the two peristaltic pump heads 35, 36 can squeeze two elastic infusion hoses 43, 44, respectively.
  • the dissolving and dispensing device may include other numbers of dissolving and dispensing channels, such as one or more than three (including three). The number of pump heads of the peristaltic pump can be set to one or more according to the number of dissolving and dispensing channels of the dissolving and dispensing device. More than three (including three).
  • the peristaltic pump setting may be a single-drive peristaltic pump, that is, the peristaltic pump may include a pump head driving device that can drive one pump head of the peristaltic pump to move or drive multiple pump heads of the peristaltic pump to move synchronously.
  • the peristaltic pump can be set as a multi-drive peristaltic pump according to the number of peristaltic pump pump heads, that is, each peristaltic pump pump head can correspond to a pump head drive device. In the example shown in FIG.
  • the peristaltic pump may include two pump head driving devices, and the two pump head driving devices respectively drive the two peristaltic pump pump heads 35 and 36 to move in a one-to-one correspondence.
  • the two peristaltic pump heads 35, 36 are driven by one pump head drive device, the number of pump head drive devices is reduced, the structure of the peristaltic pump is simplified, and the two peristaltic pump heads 35, 36 can be synchronized Action to simultaneously squeeze the two elastic infusion hoses 43, 44.
  • a linear peristaltic pump may be used as the power drive of the dissolving and dispensing device 10.
  • one pump head drive device or multiple pump head drive devices can be set to drive multiple peristaltic pump pump heads to move linearly synchronously or independently.
  • two fixing modules can be mounted on the main substrate 5 and configured to fix the medicine container, one of the dissolving and dispensing device and the two fixing modules is located above, and the other is located below .
  • the dissolving and dispensing device is located above two fixed modules, one of the fixed modules (the second fixed module) can be the clamping module 7, which is arranged to fix the second medicine container.
  • the type of the second medicine container is not limited, for example, it may be the infusion container 9; the other fixing module (the first fixing module) may be the bottle holding module 6, which is configured to fix the first medicine container.
  • the type of the first medicine container is not limited. Limit, for example, vial 8 and/or ampoule 54.
  • Two fixing modules can be installed on the front side of the main base plate 5 (that is, the side facing the operator's operation), so that the medicine container can be fixed to or removed from the fixed module.
  • the horizontal movement mechanism which can be installed on the main substrate 5 and connected to the dissolving and dispensing device, drives the dissolving and dispensing device to move in the horizontal plane, thereby causing the puncture on the two puncture bases 41, 42
  • the vertical positions of the devices 45 and 46 can be displaced horizontally, so that the dissolving and dispensing device corresponds to the at least one fixed module longitudinally.
  • the longitudinal movement mechanism can drive one of the two fixed modules and the dissolving and dispensing device to move longitudinally, so that the piercers 45, 46 on the two piercer bases 41, 42 pierce the medicine.
  • the container may be separated from the medicine container.
  • the longitudinal movement mechanism may include a first longitudinal movement mechanism and a second longitudinal movement mechanism.
  • the first longitudinal movement mechanism may be connected to the bottle holding module (the first fixed module) through the first receiving frame 12 ) 6 is connected, and drives the bottle holding module 6 to move up and down;
  • the second longitudinal movement mechanism can be connected to the clamping module (second fixed module) 7 through the second receiving frame 15, and drives the clamping module 7 to move up and down, so that The first medicine container on the bottle holding module 6 and the second medicine container on the clamping module 7 are respectively pierced by the piercers 45, 46 on the two piercer bases 41, 42 of the dissolving dispenser 10, or, The first medicine container on the bottle holding module 6 and the second medicine container on the clamping module 7 are separated from the piercers 45 and 46 on the two piercer bases 41 and 42 respectively.
  • the first longitudinal movement mechanism and the second longitudinal movement mechanism may be installed on the rear side of the main base plate 5, and the main base plate 5 may be provided with a first longitudinal chute through which the first supporting frame 12 can pass.
  • the first longitudinal chute, and the front end of the first receiving frame 12 can be connected with the bottle holding module 6, and the rear end can be connected with the first longitudinal movement mechanism;
  • the main substrate 5 can be provided with a second longitudinal chute, the second receiving frame
  • the frame 15 can pass through the second longitudinal chute, and the front end of the second receiving frame 15 can be connected with the clamping module 7 and the back end can be connected with the second longitudinal movement mechanism.
  • clamping module 7 The structure and working principle of the clamping module 7 are not described in detail in this application. You can refer to the Chinese patent application filed by the applicant named "Clamping Device and Dispensing Unit Machine” with application number CN201820517501.0.
  • the longitudinal movement mechanism is arranged on the rear side of the main base plate 5, and two fixed modules are arranged on the front side of the main base plate 5.
  • the dissolving and dispensing device may further include a sub-substrate 30.
  • Both the dissolving and dispensing device 10 and the peristaltic pump can be mounted on the sub-substrate 30, and the sub-substrate 30 may be combined with the main substrate.
  • the horizontal movement mechanism can drive the sub-base plate 30 to move. When the horizontal movement mechanism drives the sub-substrate 30 to move in the horizontal plane, it will drive the dissolving and dispensing device 10 and the peristaltic pump on the sub-substrate 30 to move.
  • the type of horizontal movement mechanism is not limited.
  • the horizontal movement mechanism can be a linear movement mechanism, and drives the sub-substrate 30 to move linearly, so that the horizontal movement mechanism drives the dissolving and dispensing device for horizontal displacement, so that the two puncture bases 41, 42 are
  • the vertical position of the piercers 45, 46 corresponds to the longitudinal position of the medicine container on one or two fixed modules, so that the corresponding longitudinally corresponding medicine container is pierced by the piercers 45, 46 to facilitate the dissolving and dispensing operation.
  • the horizontal movement mechanism is a linear movement mechanism.
  • the horizontal movement mechanism may include a first lateral guide rail 28, a first lateral slider 29, and a first lateral drive motor 27.
  • the first lateral drive The motor 27 and the first transverse guide rail 28 can be installed on the main substrate 5, and the first transverse guide rail 28 can be arranged parallel to the surface of the main substrate 5, and the first transverse slider 29 can cooperate with the first transverse guide rail 28.
  • the horizontal sliding block 29 may be connected to the sub-base 30, and the first horizontal driving motor 27 may drive the first horizontal sliding block 29 to move along the first horizontal guide rail 28.
  • the horizontal movement mechanism drives the dissolving and dispensing device to move horizontally.
  • the first lateral drive motor 27 of the horizontal movement mechanism drives the first lateral slider 29 to move along the first lateral guide rail 28, and then drives the dissolving and dispensing device 10 on the secondary substrate 30 to move laterally, so that the two piercings of the dissolving and dispensing device 10
  • the vertical positions of the piercers 45 and 46 on the bases 41 and 42 correspond to the two medicine containers on one or two fixed modules longitudinally.
  • the horizontal movement mechanism drives the dissolving and dispensing device 10 to move so that the piercing devices 45 and 46 on the two piercing device bases 41 and 42 of the dissolving and dispensing device 10 are vertical.
  • the position corresponds to the two first medicine containers placed on the bottle holding module 6 longitudinally, so that the first medicine container corresponding to the longitudinal direction is pierced by the piercers 45 and 46; or when the dissolving and dispensing unit machine dissolves and disperses other medicines,
  • the horizontal movement mechanism drives the dissolving and dispensing device 10 on the sub-base plate 30 to move, so that the vertical positions of the piercing devices 45 and 46 on the two piercing device bases 41 and 42 of the dissolving and dispensing device 10 are respectively aligned with the first fixed inside the bottle module 6
  • a medicine container is longitudinally corresponding to the second medicine container fixed in the clamping module 7, so that the first medicine container and the second medicine container corresponding to the longitudinal direction are pierced by the piercers 45 and 46, respectively.
  • the horizontal movement mechanism may be a horizontal rotation mechanism. Because the main substrate 5 and the auxiliary substrate 30 are movably connected, the horizontal rotation mechanism can drive the auxiliary substrate 30 to rotate horizontally, thereby driving the dissolving and dispensing device to rotate horizontally. During the dissolving and dispensing, the horizontal movement mechanism can rotate the dissolving and dispensing device 10 to an appropriate position, so that the vertical positions of the piercing devices 45 and 46 on the two piercing device bases 41 and 42 of the dissolving and dispensing device are respectively aligned with the bottle holding module 6
  • the two internally fixed first medicine containers correspond longitudinally, or respectively correspond to the first medicine container fixed in the bottle container 6 and the second medicine container fixed in the clamping module 7.
  • one of the two fixing modules may include a plurality of fixing units, and each fixing unit is configured to fix a medicine container.
  • the bottle holding module 6 may include a plurality of fixing units, and each fixing unit may be fixed with a first medicine container.
  • the first medicine container includes, but is not limited to, a medicine containing Vial 8 and Ampoule 54.
  • the dissolving and dispensing unit function can realize the dissolving and dispensing operations on the plurality of first medicine containers, which further improves the efficiency of dissolving and dispensing medicine.
  • the bottle holding module 6 may further include a fixing frame 55 and a rotation driving device.
  • a plurality of fixing units of the bottle holding module 6 may be fixed on the fixing frame 55 and present Circumferential arrangement, correspondingly, a plurality of first medicine containers can be placed on the fixed unit and arranged along the circumference.
  • the fixing frame 55 of the bottle holding module 6 can be designed in a disc shape, and 4 fixing units arranged along the circumferential direction of the disc are arranged on it.
  • the fixing unit may include a clamping and releasing mechanism to fix the vial 8 and/or ampoule.
  • Bottle 54 totals 4 bottles.
  • the clamping fixation or release of the vial 8 and/or ampoule 54 in the bottle holding module 6 can be realized by the clamping and releasing motor driving the clamping and releasing mechanism. Its structure and working mode are not described in detail in this application, please refer to the applicant The submitted Chinese patent application named "Medicine Bottle Holding Device and Method of Use", application number is CN201810603873.X. With the design of this patent application, the first medicine container clamped in the bottle holding module 6 can be rotated during the dissolution and dispensing process, thereby accelerating the dissolution of the medicine.
  • clamp release mechanisms and clamp release motors can be increased or decreased according to clinical use.
  • the first receiving frame 12 may be provided with a first receiving rod 40, and the first receiving rod 40 may be provided with a first locking mechanism 32, and a bottle
  • the module 6 can be installed on the first receiving rod 40 and can be fixed by the first locking mechanism 32, and the bottle holding module 6 can be removed from the first receiving rod 40 to facilitate cleaning and disinfection.
  • the bottle holding module 6 may further include a rotary driving device, which may be a rotary motor 39, or other driving methods such as pneumatic or hydraulic transmission to drive
  • a rotary driving device which may be a rotary motor 39, or other driving methods such as pneumatic or hydraulic transmission to drive
  • the rotation of the first receiving rod 40 drives the rotation of the bottle holding module 6 so that each first medicine holding container on the bottle holding module 6 can be longitudinally corresponding to the piercing device 45.
  • the rotating motor 39 can directly or indirectly drive the first receiving rod 40 to rotate through the transmission mechanism.
  • the first receiving rod 40 can drive the bottle holding module 6 to rotate, so that a first medicine holding container can be longitudinally connected to the piercing device 45.
  • the first longitudinal drive motor 23 of the first longitudinal movement mechanism can drive the first longitudinal slider 14 to move longitudinally along the first longitudinal guide rail 13, and the first longitudinal slider 14 can be driven and fixed in The first receiving rod 40 on the first receiving frame 12 and the bottle holding module 6 move longitudinally as a whole, so that the first medicine holding container longitudinally corresponding to the piercing device 45 is pierced by the piercing device 45; after the dissolution and dispensing is completed, the first longitudinal drive motor 23 can drive the first longitudinal sliding block 14 to move in the reverse direction along the first longitudinal guide rail 13, and drive the first receiving frame 12, the first receiving rod 40 and the bottle holding module 6 to move in reverse as a whole, so that the first medicine holding container and the puncture The device 45 is separated.
  • the bottle holding module 6 and the rotating drive device ie, the rotating motor 39
  • the rotating drive device can be wrapped in a sealed cover 2 to prevent liquid from splashing in and facilitate cleaning and disinfection.
  • the bottle holding module 6 may further include a vibration mechanism, which is configured to drive the first medicine container in the bottle holding module 6 to vibrate.
  • a vibration mechanism which is configured to drive the first medicine container in the bottle holding module 6 to vibrate.
  • the vibration mechanism drives the first medicine container to vibrate to promote the powder medicine The dissolution.
  • the setting of the vibration mechanism reduces the time required for the dissolution of the contents and improves the efficiency of dissolving and dispensing medicines.
  • a plurality of fixing units are fixed on the fixing frame 55 and arranged in a circle, a plurality of corresponding first medicine containers can be placed on the fixing unit on the fixing frame 55, and the first medicine containers are arranged in a circle.
  • the connection between the first medicine container on the fixing frame 55 and the rotating motor 39 is realized.
  • the rotating motor 39 drives the fixing frame 55 to rotate
  • the first medicine container on the fixing frame 55 is driven by the rotating motor 39 to make a corresponding rotation movement to adjust the first medicine container placed on the fixing frame 55
  • the position of the container allows the piercer to pierce the first medicine container one by one, thereby improving the efficiency of dispensing.
  • the bottle holding module 49 may include a fixing frame 56 and a linear drive device.
  • the fixing frame 56 may be installed on the first supporting frame 12 and may be perpendicular to the first supporting frame 12. With displacement in the direction of the board surface of the main substrate 5, a plurality of fixing units can be fixed on the fixing frame 56 and arranged linearly; correspondingly, a plurality of first medicine containers can be fixed on the fixing unit and arranged linearly.
  • the bottle holding module 49 can be designed to be linear, and the fixing frame 56 of the bottle holding module 49 can be provided with four fixing units arranged linearly, and the fixing unit can include a clamping release mechanism.
  • the clamping fixation or release of the vial 8 and/or ampoule 54 in the bottle holding module 49 can be realized by the clamping and releasing motor driving the clamping and releasing mechanism.
  • the structure and working principle are not described in detail in this application, please refer to the applicant The submitted Chinese patent application named "Medicine Bottle Holding Device and Method of Use", application number is CN201810603873.X.
  • the first medicine container clamped in the bottle holding module 49 can be rotated during the dissolution and dispensing process, thereby accelerating the dissolution of the medicine.
  • the number of clamping and releasing mechanisms can be increased or decreased according to clinical use.
  • the linear driving device of the bottle holding module 49 may include a second transverse rail 52, a second transverse sliding block 53, and a second transverse driving motor 50 that are matched with each other.
  • the two transverse slide blocks 53 and the second transverse drive motor 50 can be fixed on the first supporting frame 12, the second transverse guide rail 52 can be fixed on the fixing frame 56, and the second lateral drive motor 50 drives the transmission fixed on the fixing frame 56
  • the mechanism 51 laterally shifts or directly drives the second lateral sliding block 52 to displace, so that the second lateral sliding block 53 can move relative to each other along the second lateral guide rail 52, so that each first medicine container on the bottle holding module 49 can be realized
  • the piercer 45 of the dissolving and dispensing device 10 corresponds longitudinally.
  • the second transverse drive motor 50 can drive the transmission mechanism 51 fixed on the fixing frame 56 to move laterally, so that the second transverse sliding block 53 can move relatively along the second transverse guide rail 52 to make a first medicine holder
  • the container is longitudinally corresponding to the piercer 45; then, the first longitudinal drive mechanism drives the entire bottle holding module 49 to move longitudinally, so that the first medicinal container corresponding to the piercer 45 longitudinally is pierced by the piercer 45.
  • the first longitudinal drive drives the bottle-containing module 49 to move in reverse as a whole, so that the first medicine-containing container is separated from the piercing device 45.
  • the linear driving device can drive the fixing frame 56 to move linearly.
  • the linear driving device can be used to adjust the first medicine container on the fixing frame 56 to a proper position, so that the puncture device 45 pierces the first medicine container one by one, which facilitates the dissolution and dispensing operation, thereby improving Dispensing efficiency.
  • the fixing frame 56 of the bottle holding module 49 can be designed to move in a direction parallel to the surface of the main substrate 5 or at any angle to the surface of the main substrate 5 as required.
  • the second lateral drive motor 50 of the linear drive device may include a rotating motor and a transmission mechanism 51 (such as a gear-gear transmission mechanism, etc.) capable of converting rotary motion into linear movement, Or a linear motor can be included.
  • the linear motor can directly convert electrical energy into linear motion mechanical energy without any intermediate motion conversion mechanism. Therefore, the linear motor can directly drive the second horizontal slider 53 to move, and the linear motor has a simple structure and is suitable for dissolving and dispensing unit machines. Overall weight reduction.
  • the linear drive device can use other power structures such as pneumatic and hydraulic power structures to output linear or rotary motion.
  • the first longitudinal movement mechanism may include a first longitudinal guide rail 13, a first longitudinal slider 14 and a first longitudinal drive motor 23; wherein, the first longitudinal slider 14 It can be installed on the first supporting frame 12, the first longitudinal guide rail 13 is fixed on the main substrate 5, and the first longitudinal drive motor 23 is configured to drive the first longitudinal slider 14 to move along the first longitudinal guide rail 13.
  • the first longitudinal drive motor 23 can drive the first longitudinal slider 14 to move upward along the first longitudinal guide rail 13, and the first longitudinal slider 14 can pass and the first longitudinal slide
  • the first receiving frame 12 connected to the block 14 drives the bottle holding module 6 and the first medicine container to move upward, so that the first medicine container is pierced by the piercing device 45 for the dissolution and dispensing operation; when the dissolution and dispensing is completed, the first longitudinal direction
  • the driving motor 23 can drive the first longitudinal slider 14 to move downward along the first longitudinal guide rail 13, and the first longitudinal slider 14 can drive the bottle holding module 6 and the first medicine container to move downward through the first receiving frame 12, so that The first medicine container is separated from the piercing device 45.
  • the second longitudinal motion mechanism may include a second longitudinal guide rail 16, a second longitudinal slider 17, and a second longitudinal drive motor 24; wherein, the second longitudinal slider 17 may Fixed on the second supporting frame 15, the second longitudinal guide rail 16 can be fixed on the main substrate 5, and the second longitudinal drive motor 24 is arranged to drive the second longitudinal slider 17 to move along the second longitudinal guide rail 16.
  • the second longitudinal drive motor 24 can drive the second longitudinal slider 17 to move upward along the second longitudinal guide rail 16, and the second longitudinal slider 17 can pass through the second bearing connected to it.
  • the frame 15 drives the clamping module 7 and the second medicine container fixed therein to move upward, so that the second medicine container fixed on the clamping module 7 is pierced by the piercing device 46 for the dissolving and dispensing operation; when the dissolving and dispensing is completed After that, the second longitudinal drive motor 24 can drive the second longitudinal slider 17 to move downward along the second longitudinal guide rail 16, and the second longitudinal slider 17 can drive the clamping module 7 and the second medicine container through the second receiving frame 15 Move downward to separate the second medicine container from the piercer 46.
  • the longitudinal movement mechanism may be located on the rear side of the main base plate 5, the rear side of the main base plate 5 may be fixed with the first hood 3, and the first hood 3 may be Covering the longitudinal movement mechanism, on the one hand, is beneficial to prevent its parts from being exposed and prevent chemical liquid or dust pollution; on the other hand, when the longitudinal movement mechanism needs to be repaired, the first hood 3 can be removed to make the longitudinal movement mechanism effective The structure is exposed and then easy to repair.
  • the dissolving and dispensing device may be located above the two fixed modules, that is, the dissolving and dispensing device 10 may be above and the fixed module may be below.
  • the dissolving and dispensing device 10 is above, the clamping module 7 and the bottle holding module 6 are below, so the second medicine container (for example, the infusion container 9) and the first medicine container (for example, vials 8, ampoules 54, etc.) can be installed upright on the clamping module 7 and the bottle holding module 6, which on the one hand makes the installation of the infusion container 9 and the vials 8, and ampoules 54 easy, and on the other hand can avoid infusion The problem that the contents of the container 9, the vial 8, and the ampoule 54 are inverted when they leak.
  • the horizontal movement mechanism may be located on the rear side of the main base plate 5, and when the dissolving and dispensing device is located above the two fixed modules, the horizontal movement of the dissolving and dispensing device is driven.
  • the horizontal movement mechanism can be located above the longitudinal movement mechanism that drives the fixed module to move longitudinally. This arrangement is beneficial to simplify the structure of the dissolving and dispensing unit machine, and make the setting of the dissolving and dispensing unit machine reasonable.
  • the horizontal movement mechanism is located on the rear side of the main substrate 5.
  • the first hood 3 can cover the horizontal movement mechanism to prevent its parts from being exposed and prevent chemical liquid or dust pollution.
  • the upper part of the first hood 3 may be provided with a mounting groove, the sub-base 30 may pass through the mounting groove of the first hood 3 and then be connected to the horizontal movement mechanism, and the horizontal movement mechanism may be installed on the main base 5 so that the main base 5 Connect with the sub-substrate 30.
  • a second hood 4 may be fixed on the secondary substrate 30, and the second hood 4 may cover the components of the dissolving and dispensing device.
  • the second hood 4 it is beneficial to avoid dissolving and dispensing.
  • the components of the device are exposed to prevent liquid from splashing into the internal components; on the other hand, when the dissolving and dispensing device needs to be repaired, the second hood 4 can be removed to expose the dissolving and dispensing device, and then maintenance can be conveniently performed.
  • the dissolving and dispensing device may further include a dissolving and dispensing device fixing control mechanism installed on the sub-base 30.
  • the dissolving and dispensing device fixed control mechanism may include a third longitudinal movement mechanism, fixed clamp blocks 37, 38, and a moving clamp block 11.
  • the dissolving and dispensing device 10 may be mounted on the moving clamp block 11.
  • the third longitudinal movement mechanism can drive the moving clamp block 11 to reciprocate up and down, and drive the dissolving dispenser 10 to reciprocate up and down, so that the dissolving dispenser 10 can be clamped and fixed by the fixed clamp blocks 37, 38 and the moving clamp block 11.
  • the position of the puncture device 45, 46 is fixed, and the elastic infusion hose 43, 44 can be squeezed by the pump head 35, 36 of the peristaltic pump.
  • the third longitudinal movement mechanism may be located on the rear side of the secondary base plate 30, the dissolving and dispensing device 10 and the movement clamp 11 may be located on the front side of the secondary base plate 30, and the third longitudinal movement mechanism may be provided by the third receiving plate.
  • the frame 18 is connected to the movable clamp 11 of the fixed dissolving and dispensing device 10, and a third longitudinal chute can be provided on the secondary base plate 30, and the third supporting frame 18 can pass through the third longitudinal chute.
  • the front end can be connected with the movement clamping block 11, and the rear end can be connected with the third longitudinal movement mechanism.
  • the third longitudinal movement mechanism may include third longitudinal guide rails 19, 20, third longitudinal sliders 21, 22 and third longitudinal drive motors 25, 26.
  • the third longitudinal sliders 21, 22 can be fixed on the third supporting frame 18 and located at both ends of the third supporting frame 18, the third longitudinal guide rails 19, 20 can be fixed on the auxiliary base plate 30, and the third longitudinal drive motor 25 and 26 are arranged to drive the third longitudinal sliders 21 and 22 to move along the third longitudinal guide rails 19 and 20 respectively.
  • the moving clamp 11 of the fixing control mechanism of the dissolving and dispensing device may be located on the underside of the pump heads 35 and 36 of the peristaltic pump; the fixing clamping blocks 37 and 38 of the fixing and controlling mechanism of the dissolving and dispensing device may be arranged in the peristaltic respectively.
  • the two sides of the pump heads 35 and 36 correspond to each other.
  • the structure of the fixed clamp blocks 37, 38 and the moving clamp block 11 matches the structure of the dissolving and dispensing device 10 and the peristaltic pump heads 35, 36.
  • the third longitudinal drive motor 25, 26 can respectively drive the third longitudinal sliders 21, 22 to move upward along the third longitudinal guide rails 19, 20, and the third longitudinal sliders 21, 22 can drive the moving clamp block 11 toward the fixed clamp block through the third supporting frame 18 connected to it. 37 and 38 move.
  • the dissolving and dispensing device 10 touches the fixed clamping blocks 37 and 38 the dissolving and dispensing device 10 can be clamped and fixed by the fixed clamping blocks 37, 38 and the movable clamping block 11, so that the position of the piercing device 45, 46 Fixed, the peristaltic pump heads 35, 36 and the elastic infusion hoses 43, 44 can be squeezed and ready to be driven.
  • the dissolving and dispensing device 10 can be installed on the moving clamp 11 of the fixing and controlling mechanism of the dissolving and dispensing device; then, the third longitudinal drive device can drive the moving clamp 11 to move to the fixed clamping blocks 37, 38 to the dissolving and dispensing device 10. In contact with the fixed clamp blocks 37 and 38, the dissolving and dispensing device 10 is clamped and fixed by the fixed clamp blocks 37, 38 and the moving clamp block 11. The positions of the punctures 45 and 46 are fixed. At this time, the pump heads 35, 36 of the peristaltic pump and The elastic infusion hoses 43 and 44 are squeezed and to be driven.
  • the ampoule 54 is placed in the bottle holding module 6, and the opening of the ampoule 54 is upward, driving the clamping release motor of the bottle holding module 6 to clamp and position the ampoule 54 placed in the bottle holding module 6.
  • the placement and installation sequence of the dissolving and dispensing device 10, the infusion container 9 and the ampoule 54 can be interchanged.
  • the horizontal movement mechanism can drive the dissolving and dispensing device to move horizontally, so that the vertical axes of the piercers 45 and 46 at both ends of the dissolving and dispensing device 10 are respectively aligned with the axis of the ampoule 54 to be coordinated and the infusion container on the bottle module 6
  • the axis of the insertion port of 9 is on the same axis.
  • the first longitudinal drive motor 23 can drive the first receiving frame 12 to move longitudinally upwards, and drive the bottle holding module 6 to move longitudinally upwards, so that the piercer 45 of the dissolving and dispensing device 10 can be inserted into the ampoule 54 to be coordinated, and The puncture device 45 is inserted into the bottom of the ampoule 54 as much as possible; subsequently or in parallel, the second longitudinal drive motor 24 can drive the second receiving frame 15 to move longitudinally upward, and then drive the infusion container 9 to move longitudinally, so that the dissolving and dispensing device The piercer 46 of 10 pierces the rubber stopper of the infusion container 9.
  • the peristaltic pump works to pump the liquid medicine in the ampoule 54 into the infusion container 9 or pump all the medicine liquid in the ampoule 54 into the infusion container 9 according to the doctor's order;
  • the first longitudinal drive motor 23 is used to drive the first receiving frame 12 to reverse longitudinal displacement (downward displacement).
  • the two longitudinal drive motors 24 drive the second receiving frame 15 to reverse longitudinal displacement (downward displacement), so that the piercers 45 and 46 of the dissolving and dispensing device 10 are separated from the ampoule 54 and the infusion container 9 respectively, and the preparation operation is completed;
  • the rotating motor 39 can drive the first receiving rod 40 and the bottle holding module 6 to rotate, so that the The next ampoule 54 is rotated to the position to be coordinated, and then the first longitudinal drive motor 23 is used to drive the first receiving frame 12 to move vertically upwards, so that the piercer 45 is inserted into the next ampoule 54 and the piercer 45 is inserted as far as possible The bottom of the next ampoule 54.
  • the peristaltic pump is started, and the medicine required in the next ampoule 54 is pumped into the infusion container 9 according to the doctor's order.
  • step (ii) Repeat the above step (ii) and follow the doctor's order until all the required medicines in the ampoules 54 are pumped into the infusion container 9, at which time the dissolving and dispensing process is completed.
  • the first longitudinal drive motor 23 is used to drive the first receiving frame 12 to move downward
  • the second longitudinal drive motor 24 is used to drive the second receiving frame 15 to move downward, so that the piercing device 45, 46 is separated from the ampoule 54 and the infusion container 9 respectively, and the preparation operation is completed.
  • Step (ii) when the dissolving and dispensing unit machine shown in Figure 5 is used for this configuration operation is:
  • the first longitudinal drive motor drives the bottle holding module 49 to move downward to separate the piercer 45 from the ampoule 54; then, the second horizontal drive motor 50 drives the bottle holding module 49 Move laterally to make the bottle holding module 49 move laterally to the position of the next ampoule 54 corresponding to the longitudinal direction of the puncture; and then use the first longitudinal drive motor to drive the first receiving frame to move vertically upward, so that the puncture 45 is inserted into the next ampoule.
  • step (ii) If more than three ampoules 54 are placed in the bottle holding module 49, repeat the above step (ii) and follow the doctor's instructions until the required medicine in some ampoules 54 is pumped into the infusion container 9, and the dissolving and dispensing process is completed. .
  • the dissolving dispenser 10 can be installed on the moving clamp 11 of the fixing control mechanism of the dissolving dispenser; then, the third longitudinal drive motor 25, 26 can drive the moving clamp 11 to move to the fixed clamps 37, 38 until the dissolving The dispenser 10 is in contact with the fixed clamp blocks 37, 38, so that the dissolving dispenser 10 is clamped and fixed by the fixed clamp blocks 37, 38 and the moving clamp block 11.
  • the positions of the piercers 45, 46 are fixed, and then the peristaltic pump head 35 , 36 and the elastic infusion hose 43, 44 are squeezed and ready to be driven.
  • the placing and installation sequence of the dissolving and dispensing device 10, the infusion container 9 and the vial 8 can be interchanged.
  • the horizontal movement mechanism can drive the dissolving and dispensing device to move horizontally, so that the vertical axes of the piercers 45 and 46 at both ends of the dissolving and dispensing device 10 are respectively aligned with the axis of the vial 8 on the bottle module 6 and the insertion port of the infusion container 9
  • the shaft centers are on the same axis.
  • the first longitudinal drive motor 23 can drive the first receiving frame 12 to move vertically upwards, and drive the bottle holding module 6 to move upwards longitudinally, so that the piercer 45 of the dissolving and dispensing device 10 can be inserted into the vial 8 and the piercing device 45 Insert into the bottom of the vial 8 as much as possible, or it can be set as the piercing device 45 to just pierce the rubber stopper of the vial 8; subsequently or at the same time, the second longitudinal drive motor 24 can drive the second receiving frame 15 to move vertically upward, In turn, the infusion container 9 is driven to move longitudinally upward, so that the piercer 46 of the dissolving and dispensing device 10 pierces the rubber plug of the infusion container 9.
  • the rotating motor 31 can drive the main substrate 5 to rotate, so that the rubber stopper of the vial 8 faces downward, and at the same time the outlet of the infusion container 9 faces downward, so that the liquid inside the infusion container 9 floods the needle hole of the piercer 46.
  • the peristaltic pump works to quickly pump the liquid medicine in the infusion container 10 into the vial 8 through a dissolving and dispensing channel, and then or at the same time, pump out the liquid medicine in the vial 8 through another dissolving and dispensing channel, thereby A circulating backflow state is formed between the vial 8 and the infusion container 9, and intense turbulence is formed in the vial 8, which continuously and violently disturbs the liquid and undissolved drugs in the vial 8, and is continuously and dynamically pumped through a large amount of infusion.
  • the concentration of the limited volume of the solution in the vial 8 is continuously and rapidly diluted, so that the drug dissolves faster.
  • the vial 8 can be driven to rotate, and the first longitudinal drive motor 23 can drive the first receiving frame 12 to move back and forth longitudinally, while ensuring that the needle hole of the trocar 45 is in the vial 8, so that The solution sprayed from the piercer 45 inserted into the vial 8 can cover the inner surface of the vial 8.
  • the main substrate 5 can be rotated and/or the vibration mechanism can be driven to promote the dissolution of the medicine and balance the air pressure in the vial 8 and the infusion container 9, which greatly promotes the dissolution of the insoluble medicine.
  • the main substrate 5 is rotated to the rubber stopper of the vial 5, and the liquid medicine in the vial 8 is completely pumped into the infusion container 9; If the piercing device 45 has just pierced the rubber stopper of the vial 8, the main substrate 5 is rotated until the rubber stopper of the vial 8 is down, and the liquid medicine in the vial 8 is completely pumped into the infusion container 9.
  • the first longitudinal drive motor 23 drives the bottle holding module 6 to move in the reverse longitudinal direction, and after the piercer 45 is separated from the vial 8, the rotating motor 39 can drive the first receiving rod 40 and the bottle holding module 6 to rotate, so that the bottle holding module 6 is Next, the next vial 8 rotates to the position to be coordinated; then the first longitudinal drive motor 23 drives the first receiving frame 12 to move longitudinally upward, so that the piercer 45 pierces the rubber stopper of the next vial 8; then, follow the above
  • the medicine dissolution procedure dissolves and transfers the medicine in the next vial 8 to the infusion container 9.
  • step (ii) until all the medicine in the vial 8 is dissolved and transferred to the infusion container 9, at which time the dissolving and dispensing process is completed.
  • the first longitudinal drive motor 23 is used to drive the first supporting frame 12 to move downward
  • the second longitudinal drive motor 24 is used to drive the second supporting frame 15 to move downwards, so that the piercers 45, 45, 46 is separated from the vial 8 and the infusion container 9 to complete the preparation operation. Rotate the main substrate 5 back to the original position.
  • Step (ii) when the dissolving and dispensing unit machine shown in Figure 5 is used for this configuration operation is:
  • the first longitudinal drive motor can drive the bottle holding module 49 to move downwards to separate the piercer 45 from the vial 8; then, the second lateral drive motor 50 can drive the bottle holding module 49 to move laterally, so that the bottle holding module 49 can move laterally
  • the next vial 8 corresponds to the piercing device 45 longitudinally; then the first longitudinal drive motor is used to drive the first receiving frame to move vertically upward, so that the piercing device 45 pierces the rubber stopper of the next vial 8;
  • the dispensing procedure dissolves the medicine in the next vial 8 and transfers it to the infusion container 9.
  • step (ii) until all the drugs in the vial 8 are pumped into the infusion container 9, at which time the dissolution and dispensing process is completed.
  • the dissolving dispenser 10 can be installed on the moving clamp 11 of the fixing control mechanism of the dissolving dispenser; then, the third longitudinal drive motor 25, 26 can drive the moving clamp 11 to move to the fixed clamps 37, 38 until the dissolving The dispenser 10 is in contact with the fixed clamp blocks 37, 38, so that the dissolving dispenser 10 is clamped and fixed by the fixed clamp blocks 37, 38 and the moving clamp block 11.
  • the positions of the piercers 45, 46 are fixed, and then the peristaltic pump head 35 , 36 and the elastic infusion hose 43, 44 are squeezed and ready to be driven.
  • the placing and installation sequence of the dissolving and dispensing device 10, the infusion container 9 and the vial 8 can be interchanged.
  • the horizontal movement mechanism can drive the dissolving and dispensing device to move horizontally, so that the vertical axes of the piercers 45 and 46 at both ends of the dissolving and dispensing device 10 are respectively aligned with the axis of the vial 8 to be coordinated on the bottle module 6 and the infusion container
  • the axis of the insertion port of 9 is on the same axis.
  • the first longitudinal drive motor 23 can drive the first receiving frame 12 to move vertically upwards, and drive the bottle holding module 6 to move upwards longitudinally, so that the piercer 45 of the dissolving and dispensing device 10 is inserted into the vial 8, and the piercing device 45 is exhausted. Possibly inserted into the bottom of the vial 8, or it can be set as the piercing device 45 just pierced the rubber stopper of the vial 8; subsequently or at the same time, the second longitudinal drive motor 24 can drive the second receiving frame 15 to move upward in the longitudinal direction to drive The infusion container 9 moves longitudinally, so that the piercer 46 of the dissolving and dispensing device 10 pierces the rubber stopper of the infusion container 9.
  • the peristaltic pump works to pump the liquid medicine in the vial 8 into the infusion container 9 or pump all the liquid medicine in the vial 8 into the infusion container 9 according to the doctor's order.
  • the rotating motor 31 can also drive the main substrate 5 to rotate to make the rubber stopper of the vial 8 downward; then the peristaltic pump works and quantifies the medicine in the vial 8 according to the doctor’s instructions.
  • the liquid is pumped into the infusion container 9 or all the liquid medicine in the vial 8 is pumped into the infusion container 9.
  • the first longitudinal drive motor 23 is used to drive the first receiving frame 12 to reverse longitudinal displacement (downward displacement), and the second The longitudinal drive motor 24 drives the reverse longitudinal displacement (downward displacement) of the second receiving frame 15 so that the piercers 45 and 46 of the dissolving and dispensing device 10 are separated from the vial 8 and the infusion container 9 respectively, and the preparation operation is completed;
  • the rotating motor 39 can drive the first receiving rod 40 and the bottle holding module 6 to rotate, so that the bottle holding module 6
  • the next vial 8 of the next vial 8 is rotated to be coordinated; then the first longitudinal drive motor 23 is used to drive the first receiving frame 12 to move longitudinally upwards, so that the piercing device 45 pierces the rubber stopper of the next vial 8; according to the above dispensing procedure, Then start the peristaltic pump, and pump the medicine needed in the next vial 8 into the infusion container 9 according to the doctor's order.
  • step (ii) Repeat the above step (ii) and follow the doctor's instructions until all the required drugs in the vial 8 are transferred to the infusion container 9, at which time the dispensing process is completed.
  • the first longitudinal drive motor 23 is used to drive the first receiving frame 12 to move downward, and the second longitudinal drive motor 24 drives the second receiving frame 15 to move downwards, so that the piercers 45 and 46 of the dissolving and dispensing device 10 are respectively Separate from the vial 8 and the infusion container 9 to complete the preparation operation.
  • Step (ii) when the dissolving and dispensing unit machine shown in Figure 5 is used for this configuration operation is:
  • the first longitudinal drive motor drives the bottle holding module 49 to move downwards to separate the piercer 45 from the vial 8; then, the second lateral drive motor 50 can drive the bottle holding module 49 to move laterally, so that the bottle holding module 49 moves laterally to The position of the next vial 8 corresponding to the longitudinal direction of the puncture 45; then the first longitudinal drive motor drives the first supporting frame to move vertically upwards, so that the puncture 45 punctures the rubber stopper of the next vial 8; then, the peristaltic pump is started , Pump the required medicinal solution in the vial 8 into the infusion container 9 according to the doctor's order.
  • step (ii) Repeat the above step (ii) and follow the doctor's instructions until all the required medicines in the vials 8 are pumped into the infusion container 9, at which time the dispensing process is completed.
  • the dissolving dispenser 10 can be installed on the moving clamp 11 of the fixing control mechanism of the dissolving dispenser; then, the third longitudinal drive motor 25, 26 can drive the moving clamp 11 to move to the fixed clamps 37, 38 until the dissolving The dispenser 10 is in contact with the fixed clamp blocks 37, 38 and clamped. At this time, the pump heads 35, 36 of the peristaltic pump and the elastic infusion hoses 43, 44 are in a squeezed and ready-to-drive state.
  • the clamping release motor of the bottle holding module 6 is driven to clamp and position the ampoule 54 and the vial 8 placed in the bottle holding module 6.
  • the dissolving and dispensing device 10 the transfusion container 9, and the ampule 54 and the vial 8 are placed and installed in an interchangeable order.
  • the horizontal movement mechanism can drive the dissolving and dispensing device to move horizontally, so that the vertical axes of the piercers 45 and 46 at both ends of the dissolving and dispensing device 10 are on the bottle holding module 6 and the axis of the ampoule 54 to be coordinated and the infusion container 9 respectively.
  • the axis of the insertion port is on the same axis.
  • the first longitudinal drive motor 23 is used to drive the first supporting frame 12 to move downward
  • the second longitudinal drive motor 24 is used to drive the second supporting frame 15 to move downwards, so that the piercers 45, 45, 46 is separated from the vial 8 and the infusion container 9 to complete the preparation operation.
  • the dissolving and dispensing operation of the vial 8 can be performed first, and then the dissolving and dispensing operation of the ampoule 54; or, the vial 8 and the ampoule When 54 has multiple bottles, the dissolving and dispensing operations of the vial 8 and the ampoule 54 are alternately performed.
  • the dissolving and dispensing device 10 can be installed on the moving clamp 11; then, the third drive motor 25, 26 can drive the movable clamping block 11 to move to the fixed clamping blocks 37, 38 to the dissolving and dispensing device 10 and the fixed clamping block 37 , 38 contact, so that the dissolving and dispensing device 10 is clamped and fixed by the fixed clamp block 37, 38, and the moving clamp block 11, the position of the puncture device 45, 46 is fixed, then the peristaltic pump head 35, 36 and the elastic infusion hose 43 , 44 into squeezed and to be driven state.
  • the infusion container 10 is positioned and fixed in the clamping module 7.
  • the dissolving and dispensing device 10, the infusion container 9, and the vial 8 and the special solvent medicine bottle are placed and installed in an interchangeable order.
  • the horizontal movement mechanism can drive the dissolving and dispensing device to move horizontally, so that the vertical axes of the piercers 45 and 46 at the two ends of the dissolving and dispensing device 10 are respectively aligned with the axis of the vial 8 to be coordinated and the special solvent on the bottle module 6
  • the axis of the bottle is on the same axis.
  • the first longitudinal drive motor 23 drives the first receiving frame 12 to move upwards longitudinally, and drives the bottle holding module 6 to move upwards longitudinally, so that the piercer 45 of the dissolving and dispensing device 10 is inserted into the vial 8, and the other part of the dispensing device 10 is simultaneously melted.
  • a puncture device 46 is inserted into the special solvent medicine bottle, and the puncture device 46 is inserted into the bottom of the special solvent medicine bottle as much as possible.
  • the peristaltic pump works and quickly pumps the solution in the special solvent medicine bottle into the vial 8 through a dissolving and dispensing channel; subsequently/at the same time, the liquid in the vial 8 can be pumped out to the dedicated via another dissolving and dispensing channel
  • the solvent medicine bottle forms a circulating backflow state between the vial 8 and the special solvent medicine bottle, and intense turbulence is formed in the vial 8, which continuously violently disturbs the liquid medicine and undissolved medicine in the vial, and continues through the solution
  • the concentration of the limited volume solution in the vial 8 is continuously and rapidly diluted, so that the drug dissolves faster.
  • the vial 8 can be driven to rotate, and the first longitudinal drive motor 23 can drive the first supporting frame 12 to move back and forth longitudinally, while ensuring that the needle hole of the trocar 45 is in the vial 8.
  • the needle hole of 46 is in the special solvent medicine bottle, so that the solution sprayed from the puncture device 45 inserted into the vial 8 can cover the inner surface of the vial 8.
  • the main substrate 5 can be rotated and/or the vibration mechanism can be driven, which greatly promotes the dissolution of insoluble drugs. After the medicine is completely dissolved, all the liquid medicine in the special solvent is pumped into the vial 8.
  • the first longitudinal drive motor 23 can drive the bottle holding module 6 to move downward, so that the piercers 45 and 46 are separated from the vial 8 and the special solvent medicine bottle respectively.
  • the horizontal movement mechanism can drive the dissolving and dispensing device to move horizontally, so that the vertical axes of the piercers 45 and 46 at both ends of the dissolving and dispensing device 10 are respectively aligned with the axis of the vial 8 to be coordinated on the bottle module 6 and the infusion container 9
  • the axis of the insertion port is on the same axis.
  • the first longitudinal drive motor 23 can drive the first receiving frame 12 to move vertically upwards, and drive the bottle holding module 6 to move vertically upwards, so that the puncture 45 of the dissolving and dispensing device 10 is inserted into the vial 8, and the puncture 45 is exhausted.
  • the second longitudinal drive motor 24 can drive the second receiving frame 15 to move upward in the longitudinal direction to drive
  • the infusion container 9 moves longitudinally, so that the piercer 46 of the dissolving and dispensing device 10 pierces the rubber stopper of the infusion container 9.
  • the peristaltic pump works to pump the liquid medicine in the vial 8 into the infusion container 9 according to the doctor's order, or pump all the liquid medicine in the vial 8 into the infusion container 9.
  • the puncture device 45 has just pierced the rubber stopper of the vial 8
  • the main substrate 5 can also be rotated to make the rubber stopper of the vial 8 downward, and then the peristaltic pump will work to quantitatively pump the liquid medicine in the vial 8 according to the doctor’s instructions Into the infusion container 9 or pump all the liquid medicine in the vial 8 into the infusion container 9.
  • the first longitudinal drive motor 24 drives the first receiving frame 12 to reverse longitudinal displacement (downward displacement), and the second longitudinal drive motor 24 drives the second longitudinal displacement (downward) of the second receiving frame 15 Displacement), the piercers 45 and 46 of the dissolving and dispensing device 10 are separated from the vial 8 and the infusion container 9 respectively, and the compounding operation of the medicine containing the special solvent is completed.
  • the steps when the dissolving and dispensing unit machine shown in FIG. 5 is used for this configuration operation are basically the same as the steps when the dissolving and dispensing unit machine shown in FIGS. 1 to 4 is used for the preparation operation.
  • the movement of the components in the embodiments of the present application can be automatically controlled by the automatic dissolving and dispensing system.
  • the above-mentioned embodiment of the dissolving and dispensing unit machine and five examples of dissolving and dispensing medicine show that the dissolving and dispensing unit machine can quickly dissolve and dispense medicines and realize automatic dispensing, and has the function of independently dissolving medicines for each doctor's order. It can greatly improve the dissolution and preparation speed of insoluble drugs, and has the function of preparing drugs containing special solvents.
  • medical staff do not need to touch the drugs, and do not need to repeatedly puncture the rubber stopper of the infusion container and the rubber stopper of the vial, effectively reducing the separation of rubber stopper particles, external particles, and microbial contamination during the dispensing process.
  • the man-machine interface of the dissolving and dispensing unit machine of the embodiment of the application is friendly.
  • the installation operation of the dissolving and dispensing device, the installation operation of the first medicine container and the installation operation of the second medicine container are all operation-oriented For personnel, the operation is very convenient; in the dissolving and dispensing unit machine of the embodiment of the application, the main movement mechanisms that are not easy to clean and sterilize are separated from the dissolving and dispensing device, the first medicine container and the second medicine container on the main substrate and Both sides of the sub-base plate are installed, and the movement mechanism is closed, so that the dissolving and dispensing unit machine of the embodiment of the present application is easy to clean and disinfect.
  • the dissolving and dispensing unit machine of the embodiment of the application realizes automatic, high-efficiency, and pollution-free dispensing. While protecting the health of medical staff and patients, it greatly reduces the labor intensity of medical staff and can bring greater impact to society and patients benefit.
  • the terms “upper”, “lower”, “front”, “rear”, etc. indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for ease of description
  • the embodiments and simplified descriptions of the present application do not indicate or imply that the structure referred to has a specific orientation, is constructed and operated in a specific orientation, and therefore cannot be understood as a limitation to the embodiments of the present application.
  • connection can be a fixed connection, a detachable connection, or an integral connection; Connect directly or indirectly through an intermediary.
  • connection can be a fixed connection, a detachable connection, or an integral connection; Connect directly or indirectly through an intermediary.

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  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

L'invention concerne une machine d'unité de dissolution et d'administration de médicament utilisée pour dissoudre et administrer automatiquement un médicament, la machine comprenant : une plaque de base principale (5), un appareil de dissolution et d'administration de médicament, deux modules de fixation, un mécanisme de déplacement horizontal et un mécanisme de déplacement longitudinal, l'appareil de dissolution et d'administration de médicament étant monté sur la plaque de base principale (5), et comprenant un dispositif de dissolution et d'administration de médicament (10) et une pompe péristaltique ; le dispositif de dissolution et d'administration de médicament (10) comprend au moins un canal de dissolution et d'administration de médicament ; chaque canal de dissolution et d'administration de médicament comprend deux dispositifs de perforation (41, 42) et des tuyaux de transfusion élastiques (43, 44), qui relient les deux dispositifs de perforation (41, 42) ; et la pompe péristaltique est configurée pour presser les tuyaux de transfusion élastiques (43, 44). Les deux modules de fixation sont montés sur la plaque de base principale (5), et sont configurés pour avoir des récipients contenant des médicaments fixés dessus ; le mécanisme de déplacement horizontal est configuré pour entraîner l'appareil de dissolution et d'administration de médicament à se déplacer dans un plan horizontal de telle sorte que les deux dispositifs de perforation (41, 42) de l'appareil de dissolution et d'administration de médicament correspondent longitudinalement aux deux récipients contenant des médicaments fixés sur au moins l'un des modules de fixation ; et le mécanisme de déplacement longitudinal est configuré pour entraîner soit les deux modules de fixation, soit l'appareil de dissolution et d'administration de médicament à se déplacer longitudinalement de telle sorte que les dispositifs de perforation (41, 42) perforent les récipients contenant des médicaments ou sont séparés des récipients contenant des médicaments.
PCT/CN2020/074858 2019-02-15 2020-02-12 Machine d'unité de dissolution et d'administration de médicament WO2020164511A1 (fr)

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CN112206152B (zh) * 2020-10-22 2023-05-12 西南医科大学 一种多功能用临床药学输液自动配药装置
CN113509869A (zh) * 2021-08-06 2021-10-19 四川省医学科学院·四川省人民医院 用于配药机器人的西宁瓶承托组件

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CN103028161A (zh) * 2012-01-17 2013-04-10 深圳市卫邦科技有限公司 自动配药方法及自动配药系统
JP2013184027A (ja) * 2012-03-12 2013-09-19 Hitachi Aloka Medical Ltd 水薬調剤装置
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