WO2017162120A1 - Appareil de dissolution et de distribution de médicament - Google Patents

Appareil de dissolution et de distribution de médicament Download PDF

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Publication number
WO2017162120A1
WO2017162120A1 PCT/CN2017/077311 CN2017077311W WO2017162120A1 WO 2017162120 A1 WO2017162120 A1 WO 2017162120A1 CN 2017077311 W CN2017077311 W CN 2017077311W WO 2017162120 A1 WO2017162120 A1 WO 2017162120A1
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WO
WIPO (PCT)
Prior art keywords
puncturing
base
frame
solvent
bases
Prior art date
Application number
PCT/CN2017/077311
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English (en)
Chinese (zh)
Inventor
刘伟强
陈煊
赵罗瑞斯
Original Assignee
上海螭宿医药科技有限公司
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Application filed by 上海螭宿医药科技有限公司 filed Critical 上海螭宿医药科技有限公司
Publication of WO2017162120A1 publication Critical patent/WO2017162120A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2017—Piercing means having three or more piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents

Definitions

  • the embodiments of the present application relate to, but are not limited to, the field of infusion dispensing devices, and in particular to a solvent dispenser for automatically dissolving drugs.
  • the existing infusion-dissolving drugs are basically dispensed by using syringes and other simple forms. In the process of dispensing, they cannot be continuously prepared, and the efficiency is low, the speed is slow, and the labor intensity is large; when the packaging of the vials is packaged, due to multiple punctures of Xilin
  • the rubber stopper of the bottle and the infusion container is easy to cause leakage and particulate contamination; in the preparation of cytotoxic drugs, chemotherapeutic drugs, sensitizing drugs, high activity and other drugs, the rubber plugs of the vials and infusion containers are easily punctured, which is easy to produce.
  • Drug spillage and volatilization may bring irreversible consequences; multiple puncture of the stopper of the vial and infusion container, due to the exposure of the needle to a non-sterile environment, microorganisms may contaminate the needle, contaminated microorganisms may It will cause secondary contamination of infusion microbes with multiple punctures; manual operation is easily affected by the operator's mental state and dispensing speed requirements.
  • the state requires the establishment of a medical institution's dispensing center, which requires innovation in dispensing methods, to the point of automation, high efficiency, A non-polluting dispensing method appears.
  • the existing disposable infusion equipment and the disposable solvent dispensing device are exposed to the puncture device, and are easily stabbed when the medicine is manually dispensed, and the dispensing speed is slow, which is not suitable for automatic preparation, multiple punctures during the operation, and non-fully closed preparation.
  • Freeze-dried powder injection Xilin bottle
  • Xilin bottle can produce micro-vacuum in the production process.
  • the operator needs to repeat the puncture.
  • the internal pressure is balanced to extract the liquid.
  • the embodiments of the present application provide a solvent dispenser.
  • the solvent dispenser provided by the embodiment of the present application is used for automatically dissolving a drug, comprising:
  • each of the first puncturing devices is provided with a through inner passage, and the top end has a sharp puncturing portion, and the two first puncturing devices are mounted on the puncturing base The other two of the first puncturing devices are mounted on the other puncturing base;
  • Two first elastic infusion hoses two ends of one of the first elastic infusion hoses respectively and a bottom end of an inner passage of two of the first piercers mounted on the bases of the two piercers Connected to each other, the two ends of the other first elastic infusion hose are respectively connected to the bottom ends of the inner passages of the other two first punctors mounted on the two puncturing bases;
  • two of the first piercers on the base of the piercer are configured to pierce a drug container and communicate with the drug container;
  • Two of the first piercers on the base of the device are configured to pierce another drug container in communication with the other drug container;
  • two of the first elastic infusion hoses are configured to be in each of the Each of the first elastic infusion hoses is provided with a peristaltic pump, and the two peristaltic pumps work to squeeze two of the first elastic infusion hoses, so that the contents of the two containers are flowed and mixed with each other. Dissolving the drug.
  • At least one of the two piercing bases is movably mounted within the frame, each of the first flexible infusion hoses having a length greater than between the two piercing bases The distance does not limit the movement of the frame;
  • the first puncturing device on the movable trocar base is stored in the frame before use of the solvent dispenser; the puncturing movable when the solvent dispenser is in use The base is moved such that the first piercer thereon extends out of the frame.
  • two of the piercer bases are movably mounted within the frame.
  • the frame is provided with a needle guide corresponding to the movable trocar base a hole, the pin guide hole is a through hole penetrating a wall of the frame;
  • the solvent dispenser When the solvent dispenser is in use, it moves through the needle guide hole and along the needle guide hole to move the piercer base.
  • the length of the dial guide hole is set such that the movable piercer base is movable to a movable upper surface of the piercer base that is flush with the upper surface of the frame.
  • a movable needle piercing base is provided with a pin punching hole.
  • the movable piercer base is moved along the needle guide hole by the needle punching.
  • one of the inner side wall of the frame and the outer side wall of the moving puncturing device base is provided with a guide rail, and the other is provided with a sliding slot, and the guiding rail cooperates with the sliding slot and can be opposite Moving in the chute.
  • a pedestal guide well is disposed on both sides of the frame, and a guide rail is disposed on an inner sidewall of each pedestal guide well;
  • Two of the puncturing bases are respectively located in the pedestal guide wells on both sides, and are provided with a sliding groove that cooperates with the guide rail.
  • At least one of the two piercing bases is fixedly mounted within the frame
  • the medicated container corresponding to the fixed puncturing pedestal is moved to be pierced by the first puncturing device on which the fixed puncturing pedestal is moved.
  • the lengths of the two first puncturing devices on at least one of the two puncturing device bases are the same or different.
  • the lengths of the two first puncturing devices on each of the puncturing device bases are different;
  • the length of the portion of the trocar base is 8-10 mm, and the length of the portion of the puncturing device that exposes the puncturing base is not longer than 28 mm.
  • the middle portion of the lower end of the frame is provided with an arc-shaped recessed portion, and the two sides of the recessed portion are respectively provided with two through holes for the two first elastic infusion hoses to pass through. ;
  • the shape of the recess is configured to match the curvature of the rotation of the rollers of the two peristaltic pumps.
  • a buckle is disposed on an outer wall surface of the frame, and the buckle is configured to be engaged with the card seat.
  • the solvent dispenser further comprises:
  • At least one second elastic infusion hose At least one second elastic infusion hose
  • each pair of second puncturing devices comprising two second puncturing devices, and the structure of the second puncturing device is the same as that of the first puncturing device;
  • one of said second puncturing devices is mounted on a base of said trocar, and the other of said second puncturing devices is mounted on a base of said other puncturing device, and Two of the second puncturing devices are respectively connected to two ends of one of the second elastic infusion hoses;
  • At least one of the second elastic infusion hoses is configured to be provided with a peristaltic pump at each of the second elastic infusion hoses.
  • the embodiment of the present application further provides a disposable vial solvent dispenser for an automatic solvent dispensing system, comprising four puncture devices, two elastic infusion hoses, two puncture bases and a frame.
  • the puncturing device is hollow and forms an inner passage, and the top end of the puncturing device is open to communicate with the inner passage and is made sharp, and the bottom end is also open to communicate with the inner passage.
  • each elastic infusion hose Two ends of each elastic infusion hose are respectively connected with the bottom end of one puncturing device to form one channel, and two of the channels are parallel; two puncturing devices at each end of the two channels are fixed on a puncturing base ;
  • the frame is arched and has pedestal guide wells at both ends.
  • the two puncturing bases are respectively placed in the pedestal guide wells at both ends of the frame;
  • the middle and lower parts of the frame have arc-shaped areas, called arches, and the shape of the arches.
  • the rotations of the rollers of the two peristaltic pumps are matched, and the two inner side walls of the arches respectively penetrate two parallel holes communicating with the adjacent pedestal guide wells, and two elastic infusion hoses pass through the holes and Connected to the puncturing device on the trocar base of the pedestal guide well at both ends, and the elastic infusion hose is fixed in the tunnel;
  • the two trocar bases are located at the bottom of the pedestal guide well, and the four puncturing devices are housed in the pedestal guide well;
  • the trocar base is configured to be outwardly slid along the pedestal well through the needle device in the automatic solvent dispensing system, and the elastic infusion hose is dragged to follow the puncturing base motion, puncture The device is then removed from the pedestal guide well.
  • two puncturing devices at one end are configured to be inserted into the infusion container, and two puncturing devices at the other end are configured to be inserted into the vial; and two elastic infusion hoses are configured.
  • two elastic infusion hoses are respectively clamped and fixed between the inner top wall of the arch and the corresponding peristaltic pump roller to be crushed by the roller.
  • the flow of fluid in the flexible infusion hose is driven by the power of the peristaltic pump to perform the corresponding dissolving operation.
  • the four puncturing devices are made of medical stainless steel or medical plastic.
  • the two elastic infusion hoses are made of medical plastic material.
  • the two trocars on each puncturing base comprise a short puncturing device and a long puncturing device, and the short puncturing device exposes the pedestal base portion to a length of 8-10 mm, and the long puncturing device exposes the puncturing device base
  • the length of the part is not longer than 28 mm; or the two puncturing devices on the base of each puncturing device are equal length puncturing devices;
  • the piercing device base has a pin perforation, the pin perforation is configured to be inserted by the dialing device of the automatic solvent dispensing system to dial the piercer base; and the piercer base is provided with one or more slides The slot is intended to be guided when it is toggled.
  • one or more guide rails are provided in the pedestal guide well for the puncturing base
  • the chute fits to guide the movement of the puncturing base
  • Two pedestal guide wells are provided with equal length guide holes on both sides, and the length of the directional guide holes is set such that the upper surface of the puncturing base and the upper surface of the frame are removed after the puncturing device base is removed Reach the same plane;
  • the openings of the four holes on the inner side walls of the arch are all at the same level, and the axis line of one hole on one inner side wall of the arch is in line with the axis line of the corresponding hole on the other inner side wall of the arch.
  • the axis line of the other hole on one inner side wall of the arch is on the same straight line as the axis line of the corresponding hole on the other inner side wall of the arch, and the two straight lines are parallel to each other.
  • the disposable vial solvent dispenser is locked on the card holder of the automatic solvent dispensing system, and the elastic infusion hose can be clamped and fixed between the top wall of the frame arch and the roller of the peristaltic pump, and then the needle is inserted.
  • the device passes through the guide hole of the needle, and then penetrates into the through hole of the needle, and the two piercer bases are moved outward along the base guide well, and the puncturing device on the base of the two puncturing devices simultaneously or separately penetrates the infusion
  • the container and the vial are formed to form a two-channel internal communication closure system.
  • the two-way two-way fluid delivery is provided during the solvent dispensing process by the controllable two-way driving of the two peristaltic pumps, and the fluid is formed between the infusion container, the vial and the two channels as needed during the dissolution of the drug.
  • Different flow modes form intense turbulence in the vial, so that the drug in the vial can be quickly dissolved, and the pressure in the vial and the infusion container can be balanced to quickly dissolve the drug solution into the infusion container; the drug in the vial After completely dissolving and transferring to the infusion container, the two puncture pedestals are simultaneously or separately dialed back to the bottom of the pedestal guide well through the needle setting device, and the puncturing devices on the two pedestals are from the infusion container and the vial Pull out and complete the drug dissolution operation.
  • the solvent-dispensing device provided by the embodiment of the present invention does not need to repeatedly insert and withdraw the puncturing device in the process of dissolving the drug, and can realize the fully-closed solvent-dissolving process, which not only reduces the labor intensity of the dispensing, but also realizes continuous preparation and improves efficiency; In addition, it avoids the damage caused by liquid leakage and leakage to the dispensing personnel; at the same time, it reduces or avoids the pollution of particles and the secondary pollution of microorganisms.
  • Embodiments of the present application enable automated, highly efficient, non-polluting dispensing.
  • FIG. 1 is a schematic structural view of a solvent dispenser in an unused state according to an embodiment of the present application
  • FIG. 2 is a schematic structural view showing a state of use of a solvent dispenser according to an embodiment of the present application
  • FIG. 3 is a schematic perspective structural view showing the unused state of the solvent dispenser of the embodiment of the present application.
  • FIG. 4 is a schematic structural view showing the unused state of the solvent dispenser of the embodiment of the present application after the frame is omitted;
  • FIG. 5 is a schematic structural view showing a state in which the solvent-dissolving device of the embodiment of the present application is used after the frame is omitted;
  • FIG. 6 is a schematic structural view of a frame of a solvent dispenser according to an embodiment of the present application.
  • Fig. 7 is a schematic view showing the structure of a solvent dispenser of the embodiment of the present application for an automatic solvent dispensing system.
  • Embodiment 1 is a diagrammatic representation of Embodiment 1:
  • the sirrel bottle dissolving device is composed of four puncturing devices 28-31, two elastic infusion hoses 2-3, two puncturing device bases 14-15 and a frame 1.
  • the puncturing device 28-31 is hollow, forming an inner channel, and the apex 28-31 has a top end opening, and can be made sharp and communicates with the inner channel, and the bottom end also has an opening and an inner channel. Connected.
  • the two ends of the elastic infusion hose 2 are respectively connected with the bottom ends of the puncturing devices 29, 30, and the composition can be defined as a channel, and the elastic infusion hose 2 of the channel can be fixed to an external peristaltic pump of the automatic solvent dispensing system. 39, powered by the peristaltic pump 39, driving the fluid (such as liquid, gas, liquid-solid mixture) in the elastic infusion hose 2; the two ends of the elastic infusion hose 3 and the bottom of the piercers 28, 31, respectively The end phase is connected, and the component structure can be defined as a channel.
  • the fluid such as liquid, gas, liquid-solid mixture
  • the elastic infusion hose 3 of the channel can be fixed on an external peristaltic pump 38 of the automatic solvent dispensing system, and powered by the peristaltic pump 38 to drive the elastic infusion hose 3
  • the fluid eg, liquid, gas, liquid-solid mixture
  • reference numerals 24-27 are the junctions of the flexible infusion hoses 2, 3 and the trocars 28-31.
  • the two channels of the solvent dispenser are parallel, and the two puncturing devices 28, 29 and 30, 31 at each end are respectively fixed to a puncturing device base 14, 15 and in a parallel state.
  • the frame 1 is in the shape of an arch bridge, and the two ends are the base guide wells 22, 23.
  • the two piercer bases 14, 15 are respectively placed in the base guide wells 22, 23 at the two ends of the frame 1, And it is slidable relative to the base channel wells 22, 23.
  • the piercer bases 14, 15 are located at the bottom of the base channel wells 22, 23, at which point the piercers 28-31 are housed in the base channel wells. 22, 23; when the drug dispensing device is used, the needle device (not shown) in the automatic solvent dispensing system pushes the piercer bases 14, 15 outward along the base channel wells 22, 23, respectively, and dials
  • the flexible infusion hoses 2, 3 connected to the trocar bases 14, 15 can be dragged to follow the trocar bases 14, 15, the puncturing devices 28-31 are then withdrawn from the pedestal guide wells 22, 23 The top end of the puncturing device 28-31 is extended (as shown in FIGS.
  • the puncturing devices 28, 29 having one end connected in parallel can be inserted into the infusion container 36, and the other end is connected in parallel.
  • the puncturing device 30, 31 can be inserted Inside the vial 37. Thus, a passage through which fluid flows is formed between the infusion container 36 and the vial 37.
  • the lengths of the two elastic infusion hoses 2, 3 are greater than the distance between the two puncture bases 14, 15. Therefore, when not in use, the two elastic infusion hoses 2, 3 are in an untensioned state, such as two elastic infusion hoses 2, 3 can be coiled to save space.
  • the arcuate region of the lower portion of the frame 1 is referred to as an arch 44, and its arched design is primarily designed to match the curvature of the rollers of the two peristaltic pumps 38, 39 in the automelt dispensing system.
  • the two inner sidewalls of the arch 44 extend through two parallel bores 40-43, respectively, and the parallel bores 40, 41 communicate with adjacent pedestal guide wells 23, and the parallel bores 42, 43 communicate with adjacent pedestal guide wells 22. .
  • the two ends of the two elastic infusion hoses 2, 3 are respectively passed through the holes 40-43 on the inner side walls of the arch 44 and are fixed to the puncturing bases 14 and 15 in the pedestal guide wells 22, 23 on both sides.
  • the upper puncturing device 28-31 is connected, and the elastic infusion hoses 2, 3 can be fixed in the tunnels 40-43.
  • the four parallel holes 40-43 on the inner side walls of the arch 44 are at the same level, and the axis line of one of the holes 42 on the inner side wall of the arch 44 and the corresponding hole 40 on the other inner side wall of the arch 44
  • the axis lines are on the same straight line, and the axis line of the other hole 42 on one inner side wall of the arch 44 is on the same straight line as the axis line of the corresponding hole 41 on the other inner side wall of the arch 44, as described above.
  • the two lines are parallel to each other.
  • the two elastic infusion hoses 2, 3 located in the arch 44 are parallel to each other.
  • the frame 1 has a buckle on both sides, the buckle on one side has a buckle guide surface 8 and a buckle plane 10 , and the buckle on the other side has a buckle guide surface 9 and a buckle plane 11 .
  • the two snaps can be attached to and locked with a card holder (not shown) of the automelt dispensing system.
  • the frame 1 is fixed on the deck, the two elastic infusion hoses 2, 3 of the solvent dispenser are respectively aligned with the two peristaltic pumps 39, 38.
  • the two elastic infusion hoses 2, 3 are respectively clamped and fixed between the inner top wall of the arch 44 and the rollers of the corresponding peristaltic pumps 39, 38 for roller rolling, relying on the power of the peristaltic pumps 38, 39. Corresponding solvent operation.
  • the elastic infusion hoses 2, 3 are flexible so that they can be returned to the roller after it has been crushed
  • the original shape is such that the roller is pressed for the next time to drive the fluid flow in the elastic infusion hoses 2, 3, thereby enabling the drug in the infusion container 36 and the vial 37 to be dissolved.
  • the four puncturing devices 28-31 of the solvent dispensing device are made of medical plastics such as medical stainless steel or medical PVC to meet medical standards.
  • the two elastic infusion hoses 2 and 3 of the solvent dispenser are made of medical plastic materials (such as medical PVC, TPE, TPU, medical silica gel, etc.).
  • the two trocars on each trocar base can be designed to have different lengths or equivalent lengths.
  • the trocar base 14 has a short puncturing device 29 and a long puncturing device 28 thereon.
  • the puncturing device base 15 has a short puncturing device 31 and a long puncturing device 30, wherein the short puncturing device 29 and the long puncturing device 30 are provided.
  • Connected to both ends of the elastic infusion hose 2, the short piercer 31 and the long piercer 28 are connected to both ends of the elastic infusion hose 3.
  • the design of the long and short puncturing device on each puncturing base is mainly to produce more turbulent turbulence in the vial under the dual-channel dynamic cooperation and promote drug dissolution.
  • the length of the portion of the short puncture device 31 exposing the puncture base 15 is 8-10 mm to ensure that the liquid medicine in the vial 37 can be aspirated as much as possible; the length of the portion of the puncture device 15 that exposes the puncture base 15 Not longer than 28mm, no more than 2ml of the height of the vial 37 (usually 28mm) to prevent the cracking of the vial 37.
  • Both sides of the two pedestal wells 22 are provided with equal length guide holes 4-7, and the puncturing bases 14, 15 are provided with pin piercings 12, 13.
  • the needle setting device of the automatic solvent dispensing system passes through the needle guide holes 4-7 and penetrates the needle insertion holes 12, 13 of the piercer bases 14, 15 to dial the piercer bases 14, 15.
  • the length of the needle guiding hole 4-7 enables the puncturing device bases 14, 15 to be disengaged, and the upper plane of the puncturing device bases 14, 15 and the upper surface of the frame 1 reach the same plane, the puncturing device 28-31 It is then withdrawn from the pedestal channel wells 22, 23 and reaches the apex of its movable range.
  • One or more chutes are provided on the base of the puncture device, and one or more guide rails are arranged in the well guide well to cooperate with the chute on the base of the puncture device for the movement of the puncture base guide.
  • the puncturing device base 14 is provided with sliding grooves 32 and 33.
  • the pedestal guiding well 22 is provided with guide rails 16-18, wherein the guiding rails 16 and 17 are respectively guided with the sliding grooves 32 and 33, and the guiding rail 18 is located.
  • the two flexible infusion hoses 2, 3 can also be guided.
  • the trocar base 15 is provided with chutes 34, 35, and the pedestal guide well 23 is provided with guide rails 19-21, wherein the guide rails 19, 20 are respectively engaged with the chutes 34, 35, and the guide rails 19 are located at two Between the flexible infusion hoses 2, 3.
  • Example 1 Dissolving drug solution for powdered needle and freeze-dried powder Xilin bottled medicine
  • the frame 1 When dissolving the drug, the frame 1 can be connected to the card holder and locked by the buckles on both sides of the frame 1.
  • the two elastic infusion hoses 2, 3 are respectively fixed in position on the two peristaltic pumps 39, 38, and the two peristaltic pumps 39, 38 are respectively associated with the two elastic infusion hoses 2, 3 located at the arch 44.
  • the two elastic infusion hoses 2, 3 are respectively clamped and fixed between the inner top wall of the arch 44 and the rollers of the corresponding peristaltic pumps 39, 38 for roller rolling.
  • the needle setting device in the automatic solvent dispensing system passes through the needle guide holes 4-7, and then penetrates into the perforations 12, 13 of the trocar bases 14, 15, and the puncturing device bases 14, 15 along the pedestal guide wells 22, 23 outwardly, and the elastic infusion hoses 2, 3 connected to the trocar bases 14, 15 during the toggle can be dragged and followed by the puncturing bases 14, 15 in the pedestal wells 22, 23. Movement, the puncturing device 28-31 then pulls out the pedestal guide wells 22, 23, as shown in FIG.
  • the puncturing devices 28, 29, which are connected in parallel at one end, can be inserted into the infusion container 36 of the port downward, and the puncturing devices 30, 31 connected in parallel at the other end can be inserted into the vial 37 of the port downward.
  • the two peristaltic pumps 39, 38 simultaneously drive the two flexible infusion hoses 2, 3, and the solution in the infusion container 36 is quickly pumped into the vial 37, the duration of which is controlled by an intelligent software program.
  • one of the peristaltic pumps 38 (or 39) is reversed, the drive solution is pumped from the vial 37 into the infusion container 36, and the other peristaltic pump 39 (or 38) continues from the infusion container 36 to the Xilin.
  • the solution is pumped into the bottle 37 to form a circulating reflux state between the vial 37 and the infusion container 36, and intense turbulence is formed in the vial 37.
  • the solution of the vial solution and the undissolved drug are disturbed, and the concentration of the solution in the limited volume of the vial 37 is continuously and rapidly diluted by the continuous infusion and pumping of the infusion, thereby accelerating the dissolution of the drug.
  • the two peristaltic pumps 38, 39 completely pump the drug solution in the vial 37 into the infusion container 36. After the pumping is completed, the drug dissolving operation in the vial 37 is completed.
  • the two trocar bases 14, 15 are dialed back to the bottom of the pedestal wells 22, 23 by a needle setting device, followed by the puncturing device 28 on the two trocar bases 14, 15.
  • the -31 is pulled out from the pierced infusion container 36 and the vial 37, respectively, to complete the drug dissolution process.
  • the buckles on both sides of the frame are connected to the card holder and locked, and the two elastic infusion hoses are respectively aligned and fixed on the two peristaltic pumps.
  • the puncturing device base in the pedestal guiding well placed at both ends of the frame is dialed out, and then the puncturing device on the two puncturing device bases are simultaneously inserted into the insertion port fixed in the automatic solvent dispensing system. Down into the infusion container and vial.
  • the peristaltic pump is used to drive the elastic infusion hose connected with the short puncture of the vial end, and the liquid in the vial is directly pumped into the infusion container; the other channel provides the air pressure balance during the operation. So that the liquid is easily and quickly extracted. After the pumping is completed, the drug preparation operation in the vial is over.
  • the puncturing device base is turned back by the needle setting device, and the puncturing devices on the two puncturing device bases are respectively pulled out from the infusion container and the vial bottle, and retracted into the pedestal guide groove well to complete the dispensing operation process.
  • the dissolving process can perform the operation of rapidly dissolving the medicine and can realize automation, greatly improve the efficiency of dissolving the medicine, and greatly reduce the labor intensity of the medical staff;
  • the medical staff does not need to contact, no need to repeatedly puncture, minimize the spillage and volatilization of the drug during the dispensing process, effectively reduce the harm of the drug to the medical staff during the process of dissolving the drug, and effectively reduce the rubber plug particles in the process of dissolving the drug.
  • the pollution of foreign particles and microbes minimizes the exposure of drugs and secondary pollution of drugs, improves the safety of infusion, and helps protect the health of medical personnel and patients.
  • the solvent dispenser is designed to be easily installed in an automatic solvent dispensing system for rapid dissolution of formulated drugs for improved efficiency;
  • the puncturing device on the base of the two puncturing devices is inserted into the infusion container and the vial at the same time or separately, thereby forming a closed system of two-channel internal communication, which does not need to repeatedly puncture during the process of dissolving the formulated medicine, thereby greatly reducing the medical personnel's Labor intensity; and medical personnel do not need to contact, no need to repeatedly puncture, effectively reduce the harm of drugs to medical staff during the process of dissolving drugs, reduce drug exposure and secondary pollution of drugs, improve the safety of infusion, and help protect medical staff and Patient's health;
  • the controllable two-way driving of two peristaltic pumps provides dual-dynamic two-way fluid (such as liquid, gas, liquid-solid mixture) during the dissolution of the drug.
  • the fluid In the process of dissolving the drug, the fluid is in the infusion container, the vial and Different flow modes can be formed between the two channels (such as double-directional, double reverse, inner circulation), which can form intense turbulence in the vial, so that the drug in the vial can be quickly dissolved and can pass through the inner circulation.
  • the flow mode balances the air pressure in the vial and the infusion container, avoiding the difficulty of the injection of the liquid medicine due to the imbalance of the air pressure during the manual operation and the single-channel operation, thereby rapidly dissolving and transferring the liquid to the infusion container, so that the dissolution efficiency is high.
  • the effect of dissolving the drug is good.
  • Embodiment 2 is a diagrammatic representation of Embodiment 1:
  • the present embodiment provides a solvent dispenser which differs from the first embodiment in that it further includes at least one second elastic infusion hose (not shown) and at least one pair of second puncturing devices (not shown) And, each pair of second puncturing devices includes two second puncturing devices, and the structure of the second puncturing device is the same as that of the puncturing device 28-31.
  • one second puncturing device is mounted on the trocar base 14 and the other second puncturing device is mounted on the other puncturing device base 15 and the two second puncturing devices Minute Do not connect to both ends of a second flexible infusion hose, thus forming yet another channel.
  • a peristaltic pump is provided at each of the second flexible infusion hoses to drive the flow of liquid within the second flexible infusion hose.
  • the solvent dispenser of this embodiment forms three or more channels, making the dissolution of the drug more efficient.
  • Embodiment 3 is a diagrammatic representation of Embodiment 3
  • the trocar base in this embodiment is fixedly disposed to move within the pedestal guide well and is not movable within the pedestal guide well. In the process of dissolving the drug, the infusion container and the vial can be moved to be pierced by the puncturing device.
  • the puncturing device base does not need to be provided with a chute and a needle through hole, and the guide rail and the needle guiding hole are not required on the frame, and the length of the elastic infusion hose need not be set to be stretchable, and can be set to two
  • the distance between the bases of the piercers is adapted to simplify the structure of the drug dispenser.
  • the solvent dispenser of the present application can be used not only for the dissolution of the vials, but also for other, such as two infusion containers.
  • the embodiments of the present application improve the efficiency of dissolving the medicine, and greatly reduce the labor intensity of the medical staff; the medical staff does not need to contact, and does not need to repeatedly puncture, effectively reducing the harm of the medicine to the medical staff during the dissolution of the medicine, and reducing the exposure of the medicine. And secondary pollution of drugs, improve the safety of infusion, and help protect the health of medical staff and patients.

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

La présente invention concerne un appareil de dissolution et de distribution de médicament pour dissoudre et distribuer automatiquement des médicaments, comprenant deux bases de dispositif de perforation (14, 15) ; quatre premiers dispositifs de perforation (28-31), avec deux premiers dispositifs de perforation (28, 29) étant montés sur une base de dispositif de perforation (14), et les deux autres (30, 31) étant montés sur l'autre base de dispositif de perforation (15) ; deux premiers tuyaux de perfusion flexibles (2, 3), avec deux extrémités d'un premier tuyau de perfusion flexible (2) étant respectivement en communication avec les extrémités inférieures de passages internes des deux premiers dispositifs de perforation (29, 30) montés sur les deux bases de dispositif de perforation (14, 15), deux extrémités de l'autre premier tuyau de perfusion flexible (3) étant respectivement en communication avec les extrémités inférieures de passages internes des deux autres premiers dispositifs de perforation (28, 31) montés sur les deux bases de dispositif de perforation (14, 15). Lorsque l'appareil de dissolution et de distribution de médicament est en utilisation, les deux premiers dispositifs de perforation (28, 29) sur une base de dispositif de perforation (14) perforent un récipient de médicament (36), et les deux premiers dispositifs de perforation (30, 31) sur l'autre base de dispositif de perforation (15) perforent un autre récipient de médicament (37). De plus, une pompe péristaltique est disposée au niveau de chacun des premiers tuyaux de perfusion flexibles (2, 3), et les pompes péristaltiques fonctionnent de façon à presser les deux premiers tuyaux de perfusion flexibles (2, 3) de telle sorte que les contenus dans les deux récipients de médicament (36, 37) s'écoulent et soient mélangés mutuellement pour dissoudre et distribuer les médicaments.
PCT/CN2017/077311 2016-03-21 2017-03-20 Appareil de dissolution et de distribution de médicament WO2017162120A1 (fr)

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CN201610160676.6A CN107213016B (zh) 2016-03-21 2016-03-21 一种用于自动溶配药系统的一次性西林瓶溶配药器

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