WO2020062946A1 - 磁珠清洗装置以及化学发光免疫分析仪 - Google Patents

磁珠清洗装置以及化学发光免疫分析仪 Download PDF

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Publication number
WO2020062946A1
WO2020062946A1 PCT/CN2019/091424 CN2019091424W WO2020062946A1 WO 2020062946 A1 WO2020062946 A1 WO 2020062946A1 CN 2019091424 W CN2019091424 W CN 2019091424W WO 2020062946 A1 WO2020062946 A1 WO 2020062946A1
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WIPO (PCT)
Prior art keywords
cleaning
plate
reaction cup
group
liquid
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PCT/CN2019/091424
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English (en)
French (fr)
Inventor
房瑜
张猛
吴承云
许德晨
景宏维
孙家振
张国秀
Original Assignee
基蛋生物科技股份有限公司
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Publication of WO2020062946A1 publication Critical patent/WO2020062946A1/zh

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
    • B08B3/02—Cleaning by the force of jets or sprays
    • B08B3/022—Cleaning travelling work
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B13/00—Accessories or details of general applicability for machines or apparatus for cleaning
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto 
    • B08B9/08—Cleaning containers, e.g. tanks
    • B08B9/20—Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought
    • B08B9/28—Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought the apparatus cleaning by splash, spray, or jet application, with or without soaking
    • B08B9/30—Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought the apparatus cleaning by splash, spray, or jet application, with or without soaking and having conveyors
    • B08B9/32—Rotating conveyors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor

Definitions

  • the present application relates to the field of immunological analysis and testing, and in particular, to a magnetic bead cleaning device and a chemiluminescence immune analyzer.
  • Chemiluminescence immunoassay technology is a kind of ultra-micro analysis technology that combines chemiluminescence and immune response.
  • This technology uses a chemical or bioluminescent system as an indicator of the antigen-antibody reaction, and can quantitatively detect the concentration of the antigen or antibody based on the luminous intensity of the luminescent substance.
  • This method takes into account the high sensitivity of chemiluminescence analysis and the specificity of antibody-antigen reaction.
  • the purpose of magnetic bead cleaning is to wash away the substances that are not bound to the magnetic beads (non-target antibody antigen in the test sample, luminescent substance-labeled antibody antigen that does not participate in the reaction, etc.), so as to ensure that the test results are not interfered by other substances. .
  • the object of the present application is to provide a magnetic bead cleaning device, which solves the problems of tedious processes and complicated processes in magnetic bead cleaning and waste liquid suction in the prior art.
  • Another object of the present application is to provide a chemiluminescence immunoassay analyzer, which can realize the flowing cleaning of magnetic beads.
  • a magnetic bead cleaning device includes: a reaction cup plate, which is provided with a plurality of holes for placing reaction cups; the reaction cup plate rotates intermittently according to a cycle; a cleaning component, which includes a suction needle group and Cleaning plate group; the cleaning plate group is set on the reaction cup plate, the liquid suction needle group can penetrate through the cleaning plate group into the reaction cup to suck the waste liquid, and the cleaning plate group is provided with a cleaning tube group; and a magnetic adsorption component, magnetic adsorption
  • the assembly includes a magnetic adsorption part and a driving part for adsorbing magnetic beads; the magnetic adsorption part is connected to the reaction cup plate; the driving part is drivingly connected to the magnetic adsorption part; wherein the driving part is configured to suck the reaction cup when the liquid aspiration needle group When the waste liquid is inside, the magnetic adsorption part is driven to move closer to the reaction cup, so as to adsorb the magnetic beads on the side wall of the reaction cup.
  • the magnetic attraction part includes a magnet attraction plate, a magnet group, and a magnet base; the magnet group is connected to the magnet attraction plate, the magnet attraction plate is connected to the magnet seat, and the driving part is drivingly connected to the magnet seat; It is arranged under the cleaning plate group and connected to the reaction cup plate.
  • the driving part drives the magnet holder close to the reaction cup, the magnetic beads in the reaction cup are adsorbed on the wall of the cup.
  • the driving part is a lead screw motor, and the lead screw motor is drivingly connected to the magnet base.
  • the cleaning plate group includes a cleaning plate and a cleaning block; the cleaning block is disposed on the cleaning plate, and the liquid suction needle group passes through the cleaning block; the cleaning tube group includes a first cleaning tube and a second cleaning tube The first cleaning tube is disposed on the cleaning plate, the second cleaning tube is disposed on the cleaning block, the first cleaning tube is configured to clean the reaction cup, and the second cleaning tube is configured to clean the liquid suction needle group.
  • the cleaning block includes a first cleaning block and a second cleaning block, and a second cleaning tube is disposed on the first cleaning block.
  • the second cleaning tube includes a liquid suction tube and a liquid discharge tube, and both the liquid suction tube and the liquid discharge tube communicate with the cleaning block.
  • the liquid aspiration needle group includes a liquid aspiration needle body, a driving mechanism, and a linear guide; the driving mechanism is drivingly connected to the liquid aspiration needle body; the linear guide is connected to the reaction cup tray; The liquid suction needle body is driven to move up and down along the linear guide to extend into the reaction cup to suck the waste liquid.
  • the liquid aspiration needle group includes a first liquid aspiration needle group and a second liquid aspiration needle group.
  • the first liquid aspiration needle group and the second liquid aspiration needle group are sequentially arranged on different reaction cup plates.
  • the first liquid suction needle group is matched with the first cleaning block
  • the second liquid suction needle group is matched with the second cleaning block.
  • the reaction cup plate includes a turntable body and a driving device.
  • the driving device is drivingly connected to the turntable body to drive the turntable body to rotate intermittently in a cycle.
  • a groove is provided along the circumferential direction of the turntable body. The hole positions are sequentially arranged in the groove.
  • a chemiluminescence immune analyzer includes the above-mentioned magnetic bead cleaning device.
  • a magnetic bead cleaning device provided in this application includes a reaction cup plate, a cleaning component, and a magnetic adsorption component.
  • the reaction cup plate is provided with a plurality of holes for placing the reaction cups, and the reaction cup plate rotates intermittently according to a cycle.
  • the cleaning assembly includes a liquid suction needle group and a cleaning plate group.
  • the cleaning plate group is arranged on the reaction cup plate.
  • the liquid suction needle group can extend through the cleaning plate group and enter the reaction cup to suck waste liquid.
  • the cleaning plate group is provided with a cleaning tube group.
  • the magnetic adsorption component includes a magnetic adsorption part and a driving part for adsorbing magnetic beads.
  • the magnetic adsorption part is connected to the reaction cup plate, and the driving part is drivingly connected to the magnetic adsorption part.
  • the driving part is configured to drive the magnetic adsorption part to move closer to the reaction cup before the liquid suction needle group sucks the waste liquid in the reaction cup, so as to adsorb the magnetic beads on the side wall of the reaction cup.
  • the magnetic bead cleaning device absorbs the magnetic beads during the process of cleaning the component to suck the waste liquid, which is convenient for the cleaning component to suck the waste liquid.
  • the magnetic bead cleaning device integrates the three functions of magnetic bead adsorption, waste liquid suction, and cleaning liquid replenishment in structure, and realizes the fluidized cleaning of magnetic beads. Its simple structure and convenient control improve the cleaning quality and ensure the accuracy of subsequent measurement results.
  • the present invention provides a chemiluminescence immunoassay analyzer.
  • the chemiluminescence immunoanalyzer includes the aforementioned magnetic bead cleaning device. By providing such a magnetic bead cleaning device, the chemiluminescence immunoassay analyzer can realize the fluidized cleaning of magnetic beads.
  • FIG. 1 is a schematic structural diagram of a magnetic bead cleaning device according to a first embodiment of the present application from a first perspective;
  • FIG. 1 is a schematic structural diagram of a magnetic bead cleaning device according to a first embodiment of the present application from a first perspective;
  • FIG. 2 is a schematic structural diagram of a magnetic bead cleaning device according to a first embodiment of the present application from a second perspective;
  • FIG. 3 is a schematic structural view of a third perspective of a magnetic bead cleaning device provided by the first embodiment of the present application.
  • FIG. 4 is a schematic structural view of a fourth perspective of a magnetic bead cleaning device provided by the first embodiment of the present application.
  • Icons 100-magnetic bead cleaning device; 110-reaction cup plate; 111-turntable body; 112-drive device; 113-hole position; 114-cover plate; 120-cleaning assembly; 121- aspiration needle group; 122-cleaning Plate group; 1221-cleaning plate; 1223-first cleaning block; 1224-second cleaning block; 123-cleaning tube group; 124-first cleaning tube; 125-second cleaning tube; 130-magnetic adsorption assembly; 131- Driving part; 133-magnet adsorption plate; 134-magnet group; 135-magnet holder; 140-aspiration needle group; 141-first aspiration needle group; 142-second aspiration needle group; 143-aspiration needle body 144-drive mechanism; 145-linear guide; 146-limiting mechanism; 150-reaction cup.
  • orientations or positional relationships indicated by the terms “up” and “inner” are based on the orientations or positional relationships shown in the accompanying drawings, or the products used in this application are often used.
  • the orientation or position relationship of the placement is only for the convenience of describing the application and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, structure and operation in a specific orientation, so it cannot be understood as limit.
  • This embodiment provides a magnetic bead cleaning device 100, which includes a reaction cup tray 110, a cleaning component 120, and a magnetic adsorption component 130.
  • the cleaning component 120 is disposed in the cleaning area of the cuvette tray 110 and is used to sequentially suck the waste liquid of each cuvette 150 passing through the cleaning area and add a cleaning liquid to clean the magnetic beads.
  • the magnetic adsorption component 130 is connected to the reaction cup tray 110. When the cleaning component 120 needs to suck the waste liquid, the magnetic beads are adsorbed, which is convenient for the cleaning component 120 to suck the waste liquid.
  • the two functions of magnetic bead absorption and absorption of waste liquid and cleaning liquid addition are integrated on the structure to realize the fluidized cleaning of magnetic beads.
  • reaction cup plate 110 includes a turntable body 111 and a driving device 112.
  • the driving device 112 is drivingly connected to the turntable body 111 to drive the turntable body 111 to rotate intermittently in a cycle.
  • the above-mentioned driving device 112 includes a motor and a gear transmission assembly.
  • the motor transmission is connected to the gear transmission component, and the gear transmission component is connected to the turntable body 111, so when the motor rotates, the turntable body 111 is driven by the gear transmission component to rotate a pitch of the hole position 113 every other fixed period to make the reaction
  • the cup 150 keeps entering the washing area.
  • a slot is provided along the circumferential direction of the turntable body 111, and a plurality of hole positions 113 are sequentially arranged in the slot.
  • the plurality of holes 113 are used for placing the reaction cup 150.
  • the reaction cup 150 contains a reaction solution containing waste liquid and magnetic beads.
  • Multiple cuvettes 150 are sequentially placed in each hole position 113, and the cuvette plate 110 rotates intermittently according to the cycle.
  • the cuvette plate 110 stops for a certain time, and the magnetic adsorption component 130 adsorbs The magnetic beads in the reaction cup 150, the cleaning assembly 120 sucks the waste liquid in the reaction cup 150, and cleans the reaction cup 150 and the suction needle.
  • the cuvette tray 110 continues to rotate, and the cuvette 150 in the next hole position 113 reaches the cleaning assembly 120 to achieve fluidized cleaning.
  • the above-mentioned hole positions 113 include 45 holes. In other optional embodiments, the number of the hole positions 113 may be selected and set according to actual needs.
  • the cleaning assembly 120 includes a liquid suction needle group 121 and a cleaning plate group 122.
  • the cleaning plate group 122 is disposed on the reaction cup tray 110.
  • the liquid suction needle group 121 can extend through the cleaning plate group 122 into the reaction cup 150 to suck waste liquid.
  • the cleaning plate group 122 is provided with a cleaning tube group 123.
  • a cover plate 114 is provided on the reaction cup plate 110.
  • the cleaning plate group 122 is connected to the cover plate 114 and is located at the edge of the cuvette tray 110.
  • the area where the cleaning plate group 122 is located is the cleaning area of the cuvette tray 110.
  • the cleaning plate group 122 includes a cleaning plate 1221 and a cleaning block.
  • the cleaning block is disposed on the cleaning plate 1221, and the liquid suction needle group 121 passes through the cleaning block.
  • the cleaning plate 1221 includes two. Two cleaning plates 1221 are sequentially disposed in a cleaning area.
  • the cleaning block includes a first cleaning block 1223 and a second cleaning block 1224. On the first cleaning plate 1221, two first cleaning blocks 1223 are provided; on the second cleaning plate 1221, two second cleaning blocks 1224 are provided.
  • the cleaning tube group 123 includes a first cleaning tube 124 and a second cleaning tube 125.
  • the first cleaning tube 124 is disposed on the cleaning plate 1221.
  • the second cleaning tube 125 is disposed on the first cleaning block 1223.
  • the first cleaning tube 124 is configured to clean the cuvette 150; the second cleaning tube 125 is configured to clean the aspiration needle group 121.
  • the first cleaning pipe 124 is a steel pipe, and the steel pipe is connected to the cleaning plate 1221.
  • the cleaning liquid is sprayed into the reaction cup 150 below the cleaning plate 1221 through the steel pipe to clean the magnetic beads in the reaction cup 150.
  • two first cleaning tubes 124 are provided on the first cleaning plate 1221, and one first cleaning tube 124 is provided on the second cleaning plate 1221.
  • the number of the first cleaning tubes 124 may be selected according to actual needs.
  • a second cleaning pipe 125 is provided on each of the two first cleaning blocks 1223 on the first cleaning plate 1221.
  • the two second cleaning blocks 1224 on the second cleaning plate 1221 are not provided with a second cleaning tube 125.
  • the second cleaning pipe 125 includes a liquid suction pipe and a liquid discharge pipe, and the liquid suction pipe and the liquid discharge pipe are both connected to the first cleaning block 1223.
  • the liquid suction pipe and the liquid discharge pipe are bent steel pipes. One liquid suction and one liquid discharge are used for cleaning the liquid suction needle body 143.
  • the number of the suction pipe and the discharge pipe is selected according to actual needs.
  • the liquid aspiration needle group 140 includes a first liquid aspiration needle group 141 and a second liquid aspiration needle group 142, and the first liquid aspiration needle group 141 and the second liquid aspiration needle group 142 are sequentially disposed in the reaction
  • the holes 113 of the cup plate 110 are located at different positions.
  • the first liquid suction needle group 141 is matched with the first cleaning block 1223; the second liquid suction needle group 142 is matched with the second cleaning block 1224.
  • each of the first aspiration needle group 141 and the second aspiration needle group 142 includes two aspiration needle bodies 143.
  • a suction needle body 143 cooperates with a cleaning block.
  • each of the liquid suction needle bodies 143 can move up and down relative to the cuvette tray 110, thereby sucking the waste liquid placed in the cuvette 150 placed in the cleaning area of the cuvette tray 110.
  • liquid suction needle body 143 is driven by the driving mechanism 144 to move up and down along the linear guide 145.
  • the driving mechanism 144 is a screw motor.
  • a limiting mechanism 146 is also provided. The reliability of the liquid suction needle group 140 for sucking waste liquid is further ensured.
  • the magnetic adsorption component 130 includes a magnetic adsorption portion and a driving portion 131 for adsorbing magnetic beads.
  • the magnetic adsorption part is connected to the cuvette tray 110, and the driving part 131 is drivingly connected to the magnetic adsorption part.
  • the driving portion 131 is configured to drive the magnetic adsorption portion to move closer to the magnetic beads when the liquid suction needle group 140 sucks the waste liquid in the reaction cup 150 to adsorb the magnetic beads on the magnetic adsorption portion.
  • the magnetic attraction portion includes a magnet attraction plate 133, a magnet group 134, and a magnet holder 135. Further, the magnet group 134 is connected to the magnet attraction plate 133, the magnet attraction plate 133 is connected to the magnet base 135, and the driving portion 131 is drivingly connected to the magnet base 135.
  • the magnet group 134 is disposed below the cleaning plate group 122 and is connected to the reaction cup plate 110.
  • the driving part 131 drives the magnet holder 135 close to the reaction cup plate 110, the magnet group 134 is attracted to the reaction cup 150 to The magnetic beads in the cuvette 150 are attracted.
  • the magnet group 134 includes three pairs of magnet groups 134 and a total of six arc-shaped magnets.
  • the six arc-shaped magnets are all adsorbed on the magnet adsorption plate 133, and the magnet adsorption plate 133 is mounted on the magnet base 135.
  • the driving portion 131 is a screw motor.
  • the magnet base 135 can be driven by a screw motor, and moves back and forth along a linear slide rail provided on the magnet base 135 toward or away from the reaction cup tray 110. Specifically, before the aspiration needle reaches the reaction cup 150 for aspiration, the magnet holder 135 moves forward to adsorb the magnetic beads on the arm of the reaction cup 150; after the aspiration needle completes the aspiration, the magnet holder 135 leaves the reaction cup 150 The cleaning steel pipe sprays a cleaning liquid to clean the magnetic beads.
  • the aforementioned three pairs of arc-shaped magnets constitute a circular arc that can simultaneously complete the magnetic bead adsorption work in the seven reaction cups 150, and the seven hole positions 113 are counterclockwise. Numbered one to seven.
  • the four aspiration needles are located on two, four, six, seven, and four hole positions 113, respectively.
  • the cuvette tray 110 rotates one hole position 113 at a time according to the cycle time T and driven by the driving device 112.
  • the arc-shaped magnet is driven by the driving portion 131 to move forward along the linear slide rail and close to the outer wall of the cuvette 150.
  • the magnetic beads in the reaction cup 150 are subjected to a magnetic field and are adsorbed on the inner wall of the reaction cup 150.
  • the arc magnet returns to its initial position.
  • the cleaning process of the magnetic bead cleaning device 100 is as follows:
  • Step1 The cuvette plate 110 rotates in a cycle.
  • the cuvette 150 to be cleaned first enters the first position under the rotation of the cuvette plate 110.
  • the magnet holder 135 is driven by the driving portion 131 and moves forward along the linear slide rail, so that the arc-shaped magnet approaches the reaction cup 150.
  • the magnetic beads in the reaction cup 150 are adsorbed on the wall of the reaction cup 150.
  • the driving part 131 rotates in the reverse direction, so that the arc-shaped magnet leaves the reaction cup 150 and returns to the original position.
  • Step2 The reaction cup plate 110 rotates in a cycle, and the reaction cup 150 is sent to the second position.
  • the driving unit 131 repeats the action in step 1.
  • the liquid suction needle body 143 located above the second position is lowered into the reaction cup 150 along the linear guide 145 under the action of the driving mechanism 144.
  • Aspirate the liquid in the cuvette 150 and then exit the cuvette 150.
  • the aspiration needle body 143 passes through the first cleaning block 1223, the second cleaning tube 125 on the first cleaning block 1223, one spit and one aspiration, and the aspiration needle body 143 The residual waste liquid on the outer wall is cleaned.
  • the magnet base 135 is driven away from the reaction cup 150 along the linear sliding track under the action of the driving portion 131, and the magnetic beads in the reaction cup 150 are no longer affected by the magnetic field.
  • the first cleaning tube 124 sprays a cleaning solution on the side wall of the reaction cup 150 to break up the magnetic beads adsorbed on the wall of the reaction cup 150 for cleaning.
  • Step3 After the cleaning is finished, the reaction cup plate 110 rotates in a cycle, and the reaction cup 150 is sent to the third position.
  • the arc magnet repeats the action in step 1.
  • Step4 The cuvette plate 110 continues to rotate according to the cycle to the fourth position.
  • the action of each component on the fourth position is the same as that of the second position in step 2.
  • Step5 The reaction cup plate 110 rotates in a cycle, and the reaction cup 150 is sent to the fifth position.
  • the arc magnet repeats the action in step 1.
  • Step6 The cuvette tray 110 rotates in a cycle to send the cuvette 150 to the sixth position (the second cleaning block 1224 provided at the sixth position does not have a second cleaning tube 125, so the aspiration needle body 143 will not be carried out. Cleaning).
  • the liquid suction needle body 143 on the sixth position descends into the reaction cup 150 along the linear guide 145, sucks the liquid in the reaction cup 150, and then exits the reaction cup 150.
  • the magnet base 135 is driven away from the reaction cup 150 along the linear sliding track under the action of the driving portion 131, and the magnetic beads in the reaction cup 150 are no longer affected by the magnetic field.
  • the first cleaning tube 124 sprays a cleaning solution on the side wall of the reaction cup 150 to break up the magnetic beads adsorbed on the wall of the reaction cup 150 for cleaning.
  • Step7 The reaction cup plate 110 rotates in a cycle, and the reaction cup 150 is sent to the seventh position. Under the action of the driving part 131, the arc-shaped magnet is close to the wall of the reaction cup 150 again. The magnetic beads scattered by the first cleaning tube 124 are collected on the wall of the reaction cup 150 again under the action of the magnetic field. After the reaction cup 150 stays in the seventh position for a period of time, the liquid suction needle body 143 located above the seventh position is lowered into the reaction cup 150 along the linear guide 145 under the action of the driving mechanism 144, and the liquid in the reaction cup 150 is sucked away. Then exit the reaction cup 150 to complete the cleaning of the magnetic beads.
  • This embodiment provides a chemiluminescence immunoassay analyzer.
  • the chemiluminescence immunoanalyzer includes the magnetic bead cleaning device provided in the first embodiment. By providing such a magnetic bead cleaning device, the chemiluminescence immunoassay analyzer can realize the fluidized cleaning of magnetic beads.

Abstract

一种磁珠清洗装置包括反应杯盘（110）、清洗组件（120）以及磁性吸附组件（130），清洗组件（120）设置在反应杯盘（110）的清洗区域，用于依次吸取经过该清洗区域的各个反应杯（150）的废液以及添加清洗液清洗磁珠，磁性吸附组件（130）连接于反应杯盘（110），在清洗组件（120）需要吸取废液的过程中，将磁珠吸附住，方便清洗组件（120）吸取废液，该磁珠清洗装置（100）实现了磁珠的流水化清洗。

Description

磁珠清洗装置以及化学发光免疫分析仪 技术领域
本申请涉及免疫分析检验领域，具体而言，涉及一种磁珠清洗装置以及化学发光免疫分析仪。
背景技术
化学发光免疫分析技术是将化学发光与免疫反应相结合，建立起来的一种超微量分析技术。该技术利用化学或者生物发光系统作为抗原抗体反应的指示剂，根据发光物的发光强度，可以定量检测抗原或抗体的浓度。该方法兼顾了化学发光分析的高灵敏性和抗体抗原反应的特异性。在实际应用中，一般是利用技术手段将抗原或抗体包被于磁珠上，与待检测样本反应，同时发光物标记的另一种抗原或抗体也与待测样本反应，就完成了待测样本的标记。磁珠清洗的目的就是将未结合到磁珠上的物质(待测样本中的非目标抗体抗原，未参与反应的发光物标记的抗体抗原等)洗去，从而保证检测结果不受其他物质干扰。
目前现有的全自动化学发光免疫分析仪中，磁珠吸附吸取废液与添加清洗液两个功能在结构上分离，因此多需要辅助装置将反应杯在两个位置之间来回移动，过程繁琐，流程复杂，不适于自动化清洗。
发明内容
本申请的目的在于提供一种磁珠清洗装置，解决现有技术中磁珠清洗和废液吸取时过程繁琐，流程复杂的问题。
本申请的另一目的在于提供一种化学发光免疫分析仪，该化学发光免疫分析仪能够实现磁珠的流水化清洗。
为了实现上述目的，本申请实施例采用的技术方案如下：
一种磁珠清洗装置，包括：反应杯盘，反应杯盘上设置有多个用于放置反应杯的孔位；反应杯盘按周期间歇式旋转；清洗组件，清洗组件包括吸液针组和清洗板组；清洗板组设置在反应杯盘上，吸液针组能够穿过清洗板组伸入反应杯内吸取废液，清洗板组上设置有清洗管组；以及磁性吸附组件，磁性吸附组件包括用于吸附磁珠的磁 性吸附部和驱动部；磁性吸附部连接于反应杯盘；驱动部传动连接于磁性吸附部；其中，驱动部被配置为用于当吸液针组吸取反应杯内的废液时，驱动磁性吸附部向靠近反应杯方向运动，以将磁珠吸附在反应杯的侧壁上。
在本申请较佳的实施例中，磁性吸附部包括磁铁吸附板、磁铁组以及磁铁座；磁铁组连接于磁铁吸附板，磁铁吸附板连接于磁铁座，驱动部传动连接于磁铁座；磁铁组设置在清洗板组之下，且连接于反应杯盘，当驱动部驱动磁铁座贴近反应杯时，反应杯内的磁珠被吸附在杯壁上。
在本申请较佳的实施例中，驱动部为丝杠电机，丝杠电机传动连接于磁铁座。
在本申请较佳的实施例中，清洗板组包括清洗板和清洗块；清洗块设置在清洗板上，吸液针组穿过清洗块；清洗管组包括第一清洗管和第二清洗管，第一清洗管设置在清洗板上，第二清洗管设置在清洗块上，第一清洗管被配置为用于清洗反应杯；第二清洗管被配置为用于清洗吸液针组。
在本申请较佳的实施例中，清洗块包括第一清洗块和第二清洗块，第一清洗块上设置有第二清洗管。
在本申请较佳的实施例中，第二清洗管包括吸液管和吐液管，吸液管和吐液管均连通于清洗块内。
在本申请较佳的实施例中，吸液针组包括吸液针本体、驱动机构以及直线导轨；驱动机构传动连接于吸液针本体；直线导轨连接于反应杯盘；驱动机构被配置为用于驱动吸液针本体沿直线导轨上下运动，以伸入反应杯内吸取废液。
在本申请较佳的实施例中，吸液针组包括第一吸液针组和第二吸液针组，第一吸液针组和第二吸液针组依次设置在反应杯盘的不同孔位处；第一吸液针组与第一清洗块配合；第二吸液针组与第二清洗块配合。
在本申请较佳的实施例中，反应杯盘包括转盘本体和驱动装置，驱动装置传动连接于转盘本体，以驱动转盘本体按周期间歇式旋转；沿转盘本体的周向设置有槽，多个孔位依次设置在槽内。
一种化学发光免疫分析仪，化学发光免疫分析仪包括上述的磁珠清洗装置。
本申请的有益效果是：
本申请提供的一种磁珠清洗装置，包括反应杯盘、清洗组件以及磁性吸附组件。 其中，反应杯盘上设置有多个用于放置反应杯的孔位，反应杯盘按周期间歇式旋转。清洗组件包括吸液针组和清洗板组，清洗板组设置在反应杯盘上，吸液针组能够穿过清洗板组伸入反应杯内吸取废液，清洗板组上设置有清洗管组。磁性吸附组件包括用于吸附磁珠的磁性吸附部和驱动部，磁性吸附部连接于反应杯盘，驱动部传动连接于磁性吸附部。其中，驱动部被配置为用于当吸液针组吸取反应杯内的废液之前，驱动磁性吸附部向靠近反应杯的方向运动，以将磁珠吸附在反应杯的侧壁上。该磁珠清洗装置，在清洗组件需要吸取废液的过程中，将磁珠吸附住，方便清洗组件吸取废液。该磁珠清洗装置把磁珠吸附、废液吸取、清洗液加注三个功能在结构上一体化设置，实现了磁珠的流水化清洗。其结构简单，控制便利，提高了清洗质量，保证后续测量结果的准确性。
本申请提供的一种化学发光免疫分析仪，化学发光免疫分析仪包括上述的磁珠清洗装置。通过设置这种磁珠清洗装置，该化学发光免疫分析仪能够实现磁珠的流水化清洗。
附图说明
为了更清楚地说明本申请实施例的技术方案，下面将对实施例中所需要使用的附图作简单地介绍，应当理解，以下附图仅示出了本申请的某些实施例，因此不应被看作是对范围的限定，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他相关的附图。
图1为本申请第一实施例提供的磁珠清洗装置的第一视角的结构示意图；
图2为本申请第一实施例提供的磁珠清洗装置的第二视角的结构示意图；
图3为本申请第一实施例提供的磁珠清洗装置的第三视角的结构示意图；
图4为本申请第一实施例提供的磁珠清洗装置的第四视角的结构示意图。
图标：100-磁珠清洗装置；110-反应杯盘；111-转盘本体；112-驱动装置；113-孔位；114-盖板；120-清洗组件；121-吸液针组；122-清洗板组；1221-清洗板；1223-第一清洗块；1224-第二清洗块；123-清洗管组；124-第一清洗管；125-第二清洗管；130-磁性吸附组件；131-驱动部；133-磁铁吸附板；134-磁铁组；135-磁铁座；140-吸液针组；141-第一吸液针组；142-第二吸液针组；143-吸液针本体；144-驱动机构；145-直线导轨；146-限位机构；150-反应杯。
具体实施方式
为使本申请实施例的目的、技术方案和优点更加清楚，下面将结合本申请实施例中的附图，对本申请实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例是本申请一部分实施例，而不是全部的实施例。通常在此处附图中描述和示出的本申请实施例的组件可以以各种不同的配置来布置和设计。
因此，以下对在附图中提供的本申请的实施例的详细描述并非旨在限制要求保护的本申请的范围，而是仅仅表示本申请的选定实施例。基于本申请中的实施例，本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例，都属于本申请保护的范围。
应注意到：相似的标号和字母在下面的附图中表示类似项，因此，一旦某一项在一个附图中被定义，则在随后的附图中不需要对其进行进一步定义和解释。
在本申请实施例的描述中，需要说明的是，术语“上”、“内”等指示的方位或位置关系为基于附图所示的方位或位置关系，或者是该申请产品使用时惯常摆放的方位或位置关系，仅是为了便于描述本申请和简化描述，而不是指示或暗示所指的装置或元件必须具有特定的方位、以特定的方位构造和操作，因此不能理解为对本申请的限制。
在本申请的描述中，还需要说明的是，除非另有明确的规定和限定，术语“设置”、“安装”、“相连”、“连接”应做广义理解，例如，可以是固定连接，也可以是可拆卸连接，或一体地连接；可以是直接相连，也可以通过中间媒介间接相连，可以是两个元件内部的连通。对于本领域的普通技术人员而言，可以具体情况理解上述术语在本申请中的具体含义。
第一实施例
请参照图1-图4，本实施例提供一种磁珠清洗装置100，其包括反应杯盘110、清洗组件120以及磁性吸附组件130。清洗组件120设置在反应杯盘110的清洗区域，用于依次吸取经过该清洗区域的各个反应杯150的废液以及添加清洗液清洗磁珠。磁性吸附组件130连接于反应杯盘110，在清洗组件120需要吸取废液的过程中，将磁珠吸附住，方便清洗组件120吸取废液。该磁珠清洗装置100磁珠吸附吸取废液与添加清洗液清洗两个功能在结构上一体化设置，实现了磁珠的流水化清洗。
进一步地，反应杯盘110包括转盘本体111和驱动装置112，驱动装置112传动连接于转盘本体111，以驱动转盘本体111按周期间歇式旋转。
进一步地，在本实施例中，上述的驱动装置112包括电机和齿轮传动组件。电机传动连接于齿轮传动组件，齿轮传动组件传动连接于转盘本体111，从而当电机转动时，转盘本体111在齿轮传动组件的带动下，每隔一个固定周期旋转一个孔位113的间距，使反应杯150不断进入清洗区。
应理解，上述的转盘本体111转动的固定周期，根据实际的需要进行设置。
进一步地，沿转盘本体111的周向设置有槽，多个孔位113依次设置在槽内。多个孔位113用于放置反应杯150。
进一步地，反应杯150内盛放有包含废液和磁珠的反应液。多个反应杯150依次放置在各个孔位113中，反应杯盘110按照周期间歇式旋转，每一个孔位113经过清洗组件120时，反应杯盘110停止一定的时间，磁性吸附组件130吸附住反应杯150内的磁珠，清洗组件120吸取反应杯150内的废液，清洗反应杯150和吸取针头。然后反应杯盘110继续转动，下一个孔位113内反应杯150到达清洗组件120处，实现流水化清洗。
在本实施例中，上述的孔位113包括45个。在其他可选的实施例中，孔位113的个数可以根据实际的需要选择设置。
进一步地，清洗组件120包括吸液针组121和清洗板组122。清洗板组122设置在反应杯盘110上，吸液针组121能够穿过清洗板组122伸入反应杯150内吸取废液，清洗板组122上设置有清洗管组123。
进一步地，在反应杯盘110上设置有盖板114。清洗板组122连接于盖板114，且位于反应杯盘110的边缘处。清洗板组122所在的区域即为反应杯盘110的清洗区域。
进一步地，清洗板组122包括清洗板1221和清洗块。清洗块设置在清洗板1221上，吸液针组121穿过清洗块。
具体地，在本实施例中，清洗板1221包括两个。两个清洗板1221依次设置在清洗区域。清洗块包括第一清洗块1223和第二清洗块1224。在第一个清洗板1221上，设置有两个第一清洗块1223；在第二个清洗板1221上设置有两个第二清洗块1224。
进一步地，清洗管组123包括第一清洗管124和第二清洗管125，第一清洗管124设置在清洗板1221上，第二清洗管125设置在第一清洗块1223上，第一清洗管124被配置为用于清洗反应杯150；第二清洗管125被配置为用于清洗吸液针组121。
具体地，第一清洗管124为钢管，钢管连接于清洗板1221内，使用时，清洗液通过钢管喷入到清洗板1221下方的反应杯150内，对反应杯150内的磁珠进行清洗。在本实施例中，第一个清洗板1221上设置有两个第一清洗管124，第二个清洗板1221上设置有一个第一清洗管124。
在其他实施例中，也可以根据实际的需要选择设置第一清洗管124的个数。
进一步地，在本实施例中，在第一个清洗板1221上的两个第一清洗块1223上均设置有第二清洗管125。在第二个清洗板1221上的两个第二清洗块1224上均没有设置有第二清洗管125。第二清洗管125包括吸液管和吐液管，吸液管和吐液管均连通于第一清洗块1223内。吸液管和吐液管均为折弯钢管，一根吸液，一根吐液，用于对吸液针本体143进行清洗。
在其他实施例中，根据实际的需要选择设置吸液管和吐液管的数量。
进一步地，在本实施例中，吸液针组140包括第一吸液针组141和第二吸液针组142，第一吸液针组141和第二吸液针组142依次设置在反应杯盘110的不同孔位113处。第一吸液针组141与第一清洗块1223配合；第二吸液针组142与第二清洗块1224配合。
进一步地，第一吸液针组141和第二吸液针组142均包括两个吸液针本体143。一个吸液针本体143与一个清洗块配合。
进一步地，每一个吸液针本体143均能够相对反应杯盘110上下运动，从而吸取放置在反应杯盘110清洗区域的反应杯150内的废液。
进一步地，上述的吸液针本体143是在驱动机构144的驱动下，沿直线导轨145上下运动。
具体地，在本实施例中，上述的驱动机构144为丝杆电机。
进一步地，为防止直线导轨145的滑块脱离直线导轨145，还带有限位机构146。进一步地保证了吸液针组140吸取废液的可靠性。
进一步地，磁性吸附组件130包括用于吸附磁珠的磁性吸附部和驱动部131。磁性吸附部连接于反应杯盘110，驱动部131传动连接于磁性吸附部。驱动部131被配置为用于当吸液针组140吸取反应杯150内的废液时，驱动磁性吸附部向靠近磁珠的方向运动，以将磁珠吸附在磁性吸附部上。
具体地，在本实施例中，磁性吸附部包括磁铁吸附板133、磁铁组134以及磁铁座135。进一步地，磁铁组134连接于磁铁吸附板133，磁铁吸附板133连接于磁铁座135，驱动部131传动连接于磁铁座135。
进一步地，磁铁组134设置在清洗板组122之下，且连接于反应杯盘110，当驱动部131驱动磁铁座135靠近反应杯盘110时，磁铁组134吸附在反应杯150上，以将反应杯150内的磁珠吸引住。
具体地，在本实施例中，磁铁组134包括三对磁铁组134，共计六根弧形磁铁。六根弧形磁铁均吸附在磁铁吸附板133上，磁铁吸附板133安装在磁铁座135上。
进一步地，在本实施例中，驱动部131为丝杆电机。磁铁座135能够由丝杆电机带动，沿设置在磁铁座135上的直线滑轨向靠近或者远离反应杯盘110的方向前后移动。具体地，在吸液针伸入反应杯150吸液之前，磁铁座135向前移动，将磁珠吸附在反应杯150臂上；吸液针完成吸液返回后，磁铁座135离开反应杯150，清洗钢管喷出清洗液对磁珠进行清洗。
参照图1，在本实施例中，前述的三对弧形磁铁，其构成的圆弧，可同时完成七个反应杯150内的磁珠吸附工作，将这七个孔位113按逆时针方向依次编号为一至七。四根吸液针分别位于二、四、六、七，四个孔位113之上。反应杯盘110按照周期时间T，在驱动装置112驱动下，每次旋转一个孔位113。在一至七号孔位113存在待清洗的反应杯150时，在每个周期时间T内，弧形磁铁在驱动部131驱动下，沿直线滑轨向前移动，贴近反应杯150外壁。反应杯150内的磁珠受到磁场作用，被吸附在反应杯150内壁上。在周期时间T快要结束时，弧形磁铁退回初始位置。
该磁珠清洗装置100进行清洗的过程如下：
Step1：反应杯盘110按周期旋转，待清洗的反应杯150在反应杯盘110的旋转下，首先进入一号位。此时磁铁座135被驱动部131驱动，沿着直线滑轨向前移动，使弧形磁铁靠近反应杯150。反应杯150内的磁珠在磁场影响下，吸附于反应杯150壁上，吸附一段时间后，驱动部131反向转动，使弧形磁铁离开反应杯150，回到原位。
Step2：反应杯盘110按周期旋转，将反应杯150送到二号位。驱动部131重复step1中动作，反应杯150在二号位停留一段时间后，位于二号位上方的吸液针本体143，在驱动机构144作用下，沿直线导轨145下降至反应杯150内，吸走反应杯150 内液体，而后退出反应杯150。在退出反应杯150的过程中，吸液针本体143会经过第一清洗块1223，第一清洗块1223上的第二清洗管125，一根吐液，一根吸液，将吸液针本体143外壁残留的废液清洗干净。吸液针本体143恢复原位后，磁铁座135在驱动部131作用下，沿直线滑轨远离反应杯150，反应杯150内的磁珠不再受磁场影响。此时，第一清洗管124向反应杯150侧壁上喷出清洗液，打散吸附在反应杯150壁上的磁珠，进行清洗。
Step3：清洗结束后，反应杯盘110按周期旋转，将反应杯150送至三号位，弧形磁铁重复step1中动作
Step4：反应杯盘110继续按周期旋转，来到四号位。四号位上的各部件动作与step2中二号位动作相同。
Step5：反应杯盘110按周期旋转，将反应杯150送至五号位，弧形磁铁重复step1中动作。
Step6：反应杯盘110按周期旋转，将反应杯150送至六号位(六号位处设置的第二清洗块1224上没有设置第二清洗管125，因此不会对吸液针本体143进行清洗)。六号位上的吸液针本体143在驱动机构144作用下，沿直线导轨145下降至反应杯150内，吸走反应杯150内液体，而后退出反应杯150。吸液针本体143恢复原位后，磁铁座135在驱动部131作用下，沿直线滑轨远离反应杯150，反应杯150内的磁珠不再受磁场影响。此时，第一清洗管124向反应杯150侧壁上喷出清洗液，打散吸附在反应杯150壁上的磁珠，进行清洗。
Step7：反应杯盘110按周期旋转，将反应杯150送至七号位。弧形磁铁在驱动部131作用下，又靠近反应杯150壁，被第一清洗管124喷散的磁珠在磁场作用下再次聚集到反应杯150壁上。反应杯150在七号位停留一段时间后，位于七号位上方的吸液针本体143，在驱动机构144作用下，沿直线导轨145下降至反应杯150内，吸走反应杯150内液体，而后退出反应杯150，完成磁珠的清洗工作。
第二实施例
本实施例提供一种化学发光免疫分析仪，该化学发光免疫分析仪包括第一实施例提供的磁珠清洗装置。通过设置这种磁珠清洗装置，该化学发光免疫分析仪能够实现磁珠的流水化清洗。
以上所述仅为本申请的优选实施例而已，并不用于限制本申请，对于本领域的技 术人员来说，本申请可以有各种更改和变化。凡在本申请的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本申请的保护范围之内。应注意到：相似的标号和字母在下面的附图中表示类似项，因此，一旦某一项在一个附图中被定义，则在随后的附图中不需要对其进行进一步定义和解释。

Claims (10)

  1. 一种磁珠清洗装置，其特征在于，包括：
    反应杯盘，所述反应杯盘上设置有多个用于放置反应杯的孔位；所述反应杯盘按周期间歇式旋转；
    清洗组件，所述清洗组件包括吸液针组和清洗板组；所述清洗板组设置在所述反应杯盘上，所述吸液针组能够穿过所述清洗板组伸入所述反应杯内吸取废液，所述清洗板组上设置有清洗管组；以及
    磁性吸附组件，所述磁性吸附组件包括用于吸附磁珠的磁性吸附部和驱动部；所述磁性吸附部连接于所述反应杯盘；所述驱动部传动连接于所述磁性吸附部；
    其中，所述驱动部被配置为用于当所述吸液针组吸取所述反应杯内的废液之前，驱动所述磁性吸附部向靠近所述反应杯的方向运动，以将所述磁珠吸附在所述反应杯的侧壁上。
  2. 如权利要求1所述的磁珠清洗装置，其特征在于，
    所述磁性吸附部包括磁铁吸附板、磁铁组以及磁铁座；
    所述磁铁组连接于所述磁铁吸附板，所述磁铁吸附板连接于所述磁铁座，所述驱动部传动连接于所述磁铁座；
    所述磁铁组设置在所述清洗板组之下，且连接于所述反应杯盘，当所述驱动部驱动所述磁铁座贴近所述反应杯时，所述反应杯内的所述磁珠被吸附在杯壁上。
  3. 如权利要求2所述的磁珠清洗装置，其特征在于，
    所述驱动部为丝杠电机，所述丝杠电机传动连接于所述磁铁座。
  4. 如权利要求1所述的磁珠清洗装置，其特征在于，
    所述清洗板组包括清洗板和清洗块；
    所述清洗块设置在所述清洗板上，所述吸液针组穿过所述清洗块；
    所述清洗管组包括第一清洗管和第二清洗管，所述第一清洗管设置在所述清洗板上，所述第二清洗管设置在所述清洗块上，所述第一清洗管被配置为用于清洗所述反应杯；所述第二清洗管被配置为用于清洗所述吸液针组。
  5. 如权利要求4所述的磁珠清洗装置，其特征在于，
    所述清洗块包括第一清洗块和第二清洗块，
    所述第一清洗块上设置有所述第二清洗管。
  6. 如权利要求5所述的磁珠清洗装置，其特征在于，
    所述第二清洗管包括吸液管和吐液管，所述吸液管和所述吐液管均连通于所述清洗块内。
  7. 如权利要求1所述的磁珠清洗装置，其特征在于，
    所述吸液针组包括吸液针本体、驱动机构以及直线导轨；
    所述驱动机构传动连接于所述吸液针本体；所述直线导轨连接于所述反应杯盘；
    所述驱动机构被配置为用于驱动所述吸液针本体沿所述直线导轨上下运动，以伸入所述反应杯内吸取废液。
  8. 如权利要求5所述的磁珠清洗装置，其特征在于，
    所述吸液针组包括第一吸液针组和第二吸液针组，所述第一吸液针组和所述第二吸液针组依次设置在所述反应杯盘的不同孔位处；
    所述第一吸液针组与所述第一清洗块配合；所述第二吸液针组与所述第二清洗块配合。
  9. 如权利要求1-8任一项所述的磁珠清洗装置，其特征在于，
    所述反应杯盘包括转盘本体和驱动装置，所述驱动装置传动连接于所述转盘本体，以驱动所述转盘本体按周期间歇式旋转；沿所述转盘本体的周向设置有槽，多个所述孔位依次设置在所述槽内。
  10. 一种化学发光免疫分析仪，其特征在于，所述化学发光免疫分析仪包括如权利要求1-9任一项所述的磁珠清洗装置。
PCT/CN2019/091424 2018-09-28 2019-06-14 磁珠清洗装置以及化学发光免疫分析仪 WO2020062946A1 (zh)

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CN110508548A (zh) * 2019-09-19 2019-11-29 南京迪格诺斯生物技术有限公司 一种化学发光分析仪的冲洗室吸附系统
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