WO2020059997A8 - 전이금속 복합체를 포함하는 산화-환원 고분자 및 이를 이용한 전기화학적 바이오센서 - Google Patents

전이금속 복합체를 포함하는 산화-환원 고분자 및 이를 이용한 전기화학적 바이오센서 Download PDF

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WO2020059997A8
WO2020059997A8 PCT/KR2019/006000 KR2019006000W WO2020059997A8 WO 2020059997 A8 WO2020059997 A8 WO 2020059997A8 KR 2019006000 W KR2019006000 W KR 2019006000W WO 2020059997 A8 WO2020059997 A8 WO 2020059997A8
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WIPO (PCT)
Prior art keywords
oxidation
transition metal
metal complex
electrochemical biosensor
same
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PCT/KR2019/006000
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English (en)
French (fr)
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WO2020059997A1 (ko
Inventor
강영재
신현서
양보나
정인석
이진선
곽수민
양현희
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주식회사 아이센스
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Priority to US17/276,760 priority Critical patent/US20210347926A1/en
Priority to EP19862947.9A priority patent/EP3854827B1/en
Priority to AU2019341169A priority patent/AU2019341169B2/en
Priority to JP2021514521A priority patent/JP7083069B2/ja
Publication of WO2020059997A1 publication Critical patent/WO2020059997A1/ko
Publication of WO2020059997A8 publication Critical patent/WO2020059997A8/ko

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F226/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C08F226/06—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a heterocyclic ring containing nitrogen
    • C—CHEMISTRY; METALLURGY
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    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/42—Introducing metal atoms or metal-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/334—Polymers modified by chemical after-treatment with organic compounds containing sulfur
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/334—Polymers modified by chemical after-treatment with organic compounds containing sulfur
    • C08G65/3344—Polymers modified by chemical after-treatment with organic compounds containing sulfur containing oxygen in addition to sulfur
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/338—Polymers modified by chemical after-treatment with inorganic and organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/004—Enzyme electrodes mediator-assisted
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3277—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a redox reaction, e.g. detection by cyclic voltammetry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01B—CABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
    • H01B13/00—Apparatus or processes specially adapted for manufacturing conductors or cables
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System compounds of the platinum group
    • C07F15/002—Osmium compounds
    • C07F15/0026—Osmium compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2810/00—Chemical modification of a polymer

Abstract

본 발명은 특유의 구조를 가짐으로 인해 기존에 대비하여 간이한 단계로 제조가 가능하며, 전이금속 복합체의 고정화율이 증가되고 작용기 또는 링커의 도입이 용이한, 전이금속 복합체를 포함하는 산화-환원 중합체, 이의 제조방법 및 상기 산화-환원중합체를 포함하는 전기화학적 바이오센서에 관한 것이다.
PCT/KR2019/006000 2018-09-18 2019-05-09 전이금속 복합체를 포함하는 산화-환원 고분자 및 이를 이용한 전기화학적 바이오센서 WO2020059997A1 (ko)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US17/276,760 US20210347926A1 (en) 2018-09-18 2019-05-09 Oxidation-reduction polymer including transition metal complex, and electrochemical biosensor using same
EP19862947.9A EP3854827B1 (en) 2018-09-18 2019-05-09 Oxidation-reduction polymer including transition metal complex, and electrochemical biosensor using same
AU2019341169A AU2019341169B2 (en) 2018-09-18 2019-05-09 Oxidation-reduction polymer including transition metal complex, and electrochemical biosensor using same
JP2021514521A JP7083069B2 (ja) 2018-09-18 2019-05-09 遷移金属複合体を含む酸化－還元高分子およびこれを利用した電気化学的バイオセンサ

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20180111633 2018-09-18
KR10-2018-0111633 2018-09-18

Publications (2)

Publication Number Publication Date
WO2020059997A1 WO2020059997A1 (ko) 2020-03-26
WO2020059997A8 true WO2020059997A8 (ko) 2021-04-08

Family

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PCT/KR2019/006000 WO2020059997A1 (ko) 2018-09-18 2019-05-09 전이금속 복합체를 포함하는 산화-환원 고분자 및 이를 이용한 전기화학적 바이오센서

Country Status (6)

Country Link
US (2) US20210347926A1 (ko)
EP (2) EP3854827B1 (ko)
JP (2) JP7083069B2 (ko)
KR (1) KR102244655B1 (ko)
AU (2) AU2019341169B2 (ko)
WO (1) WO2020059997A1 (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220096570A (ko) * 2020-12-31 2022-07-07 주식회사 아이센스 펜타플루오로페닐 에스터를 포함하는 고분자 및 이를 포함하는 전기화학적 바이오센서
KR102589294B1 (ko) * 2021-08-03 2023-10-13 단국대학교 천안캠퍼스 산학협력단 작동전극, 이의 제조방법 및 이를 포함하는 바이오센서 및 생체연료전지
WO2023062931A1 (ja) * 2021-10-15 2023-04-20 デンカ株式会社 化合物及び当該化合物の製造方法
CN115215953B (zh) * 2022-07-15 2023-10-24 江西司托迈医疗科技有限公司 自组装氧化还原聚合物、传感器及其制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62241924A (ja) * 1986-04-14 1987-10-22 Nippon Shokubai Kagaku Kogyo Co Ltd ポリエン−ポリチオ−ル系硬化性組成物
US5264104A (en) * 1989-08-02 1993-11-23 Gregg Brian A Enzyme electrodes
JP3083307B2 (ja) * 1990-01-12 2000-09-04 旭電化工業株式会社 光学的造形用樹脂組成物
JP3181284B2 (ja) * 1990-01-12 2001-07-03 旭電化工業株式会社 エネルギー線反応性粘着剤組成物
JP5308609B2 (ja) 1999-11-15 2013-10-09 アボット ダイアベティス ケア インコーポレイテッド ポリマー遷移金属錯体及びその用途
US6676816B2 (en) 2001-05-11 2004-01-13 Therasense, Inc. Transition metal complexes with (pyridyl)imidazole ligands and sensors using said complexes
US6932894B2 (en) * 2001-05-15 2005-08-23 Therasense, Inc. Biosensor membranes composed of polymers containing heterocyclic nitrogens
GB0711849D0 (en) 2007-06-19 2007-07-25 Oxford Biosensors Ltd Redox Mediators
US20090294307A1 (en) 2008-06-02 2009-12-03 Zenghe Liu Redox polymer based reference electrodes having an extended lifetime for use in long term amperometric sensors
KR20140132869A (ko) * 2013-05-08 2014-11-19 동국대학교 산학협력단 혈당, 당화 단백질 및 총 단백질을 측정할 수 있는 바이오 센서 어레이
AU2015302326A1 (en) 2014-08-15 2017-03-02 Abbott Diabetes Care Inc. Temperature insensitive in vivo analyte devices, methods and systems
KR101694982B1 (ko) * 2014-12-31 2017-01-10 주식회사 아이센스 전기화학적 바이오센서
KR102430818B1 (ko) * 2015-10-02 2022-08-11 삼성디스플레이 주식회사 하이브리드 수지 제조용 조성물, 이로부터 제조된 하이브리드 수지 및 하이브리드 수지 필름
CA3065339A1 (en) 2017-06-30 2019-01-03 Abbott Diabetes Care Inc. Method and apparatus for analyte detection using an electrochemical biosensor

Also Published As

Publication number Publication date
AU2019341169A1 (en) 2021-04-15
JP7083069B2 (ja) 2022-06-09
WO2020059997A1 (ko) 2020-03-26
US20220025114A1 (en) 2022-01-27
EP3854833A1 (en) 2021-07-28
US20210347926A1 (en) 2021-11-11
JP7237141B2 (ja) 2023-03-10
EP3854827A1 (en) 2021-07-28
AU2019343627A1 (en) 2021-04-01
KR102244655B1 (ko) 2021-04-26
AU2019343627B2 (en) 2023-02-16
KR20200032653A (ko) 2020-03-26
JP2021532899A (ja) 2021-12-02
EP3854833A4 (en) 2022-09-07
JP2022501588A (ja) 2022-01-06
EP3854827A4 (en) 2022-07-06
EP3854827B1 (en) 2023-11-08
AU2019341169B2 (en) 2022-07-28

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