WO2020020169A1 - 样本分析装置及其清洗方法 - Google Patents

样本分析装置及其清洗方法 Download PDF

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Publication number
WO2020020169A1
WO2020020169A1 PCT/CN2019/097319 CN2019097319W WO2020020169A1 WO 2020020169 A1 WO2020020169 A1 WO 2020020169A1 CN 2019097319 W CN2019097319 W CN 2019097319W WO 2020020169 A1 WO2020020169 A1 WO 2020020169A1
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WIPO (PCT)
Prior art keywords
cleaning
sub
sample
instruction
controller
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PCT/CN2019/097319
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English (en)
French (fr)
Inventor
习武佳
许焕樟
翟留伟
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深圳市帝迈生物技术有限公司
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Publication of WO2020020169A1 publication Critical patent/WO2020020169A1/zh

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers

Definitions

  • the present application relates to the technical field of immunoassay, and in particular to a sample analysis device and a cleaning method thereof.
  • the immune analysis device uses a latex immune response reagent to perform a latex immune reaction with a sample to be detected, and uses a laser scattering or transmission detection method to complete a latex immune analysis.
  • the immunoassay device In order to facilitate the maintenance and reuse of the immunoassay device, to extend the use period of the immunoassay device and to ensure the reliability of the sample analysis results, the immunoassay device usually needs to be cleaned.
  • a conventional blood hemolysing agent or a test solution after a routine blood reaction is used to clean the immune analysis device, that is, the immune analysis device is cleaned after each latex immune analysis reaction and analysis.
  • the inventors of the present application found in the long-term research and development process that the above-mentioned cleaning method has the following defects: first, the consumption of conventional blood hemolysing agents will increase, and the cost will greatly increase; second, the conventional blood hemolysing agents generally compare with immune hemolysis The reagent has stronger hemolysis ability, and each time the routine blood hemolysing reagent or the test solution after the routine blood reaction is used for rinsing, the risk of contamination of the latex immune reagent is increased, resulting in unreliable results.
  • the technical problem mainly solved by this application is to provide a sample analysis device and a cleaning method thereof, which can save specific cleaning liquids and reduce pollution of specific cleaning liquids on the basis of ensuring the cleaning effect, the precision of the device detection and the accuracy of the sample detection results.
  • a technical solution adopted in the present application is to provide a sample analysis device, the sample analysis device includes an immune analysis sub-device, and the device further includes: a controller connected to the immune analysis sub-device For controlling the immune analysis sub-device to detect its own first background voltage value when there is no sample to be detected, and to determine the immunity according to a comparison between the first background voltage value and a preset background voltage threshold value Analyze the cleaning mode of the sub-device and send the corresponding cleaning instruction; a cleaning subsystem, connected to the controller, is used to receive the cleaning instruction sent by the controller, and respond to the cleaning instruction to the immune analysis sub-device Perform the corresponding cleaning.
  • Another technical solution adopted in the present application is to provide a method for cleaning a sample analysis device.
  • the method is suitable for the sample analysis device as described above, and the method includes: controlling the immune analyzer
  • the device detects its own first background voltage value when there is no sample to be detected; according to a comparison between the first background voltage value and a preset background voltage threshold, a cleaning mode of the immune analysis sub-device is determined and a corresponding response is sent.
  • sample analysis device includes:
  • Immunoassay sub-device which comprises a colorimetric cell, and a laser and a photoelectric receiver respectively disposed on both sides of the colorimetric cell.
  • the colorimetric cell is used for installing an immersion liquid when no detection is performed.
  • the colorimetric cell is used for discharging the soaking solution and sequentially installing a bottom liquid and a sample to be tested during the detection, and the laser is configured to emit a laser toward the colorimetric cell so that the photoelectric receiver obtains an optical signal and Converted into electrical signals, wherein the electrical signal obtained when the photoelectric receiver discharges the soaking solution and only contains the bottom liquid is the first background electrical signal;
  • the controller is configured to receive the first background electrical signal, compare the first background electrical signal with a preset background electrical signal, and issue a corresponding cleaning instruction.
  • a sample analysis device including:
  • the photoelectric detection component is configured to obtain a first background electrical signal by performing detection when the container only contains the bottom liquid, and performing detection to obtain a sample detection when the container holds the bottom liquid and a sample to be detected. electric signal;
  • the sample analysis device of the present application includes an immune analysis sub-device, and further includes a controller connected to the immune analysis sub-device for controlling the immune analysis sub-device When there is no sample to be detected, the first background voltage value of itself is detected, and the cleaning mode of the immunoassay sub-device is determined according to a comparison between the first background voltage value and a preset background voltage threshold, and a corresponding A cleaning instruction; a cleaning subsystem, connected to the controller, configured to receive a cleaning instruction sent by the controller, and perform corresponding cleaning on the immune analysis sub-device in response to the cleaning instruction.
  • the cleaning mode of the immune analysis sub-device is determined and sent according to the comparison between the first background voltage value and the preset background voltage threshold.
  • Corresponding cleaning instructions to perform corresponding cleaning on the immune analysis sub-device and determine the cleaning mode of the immune analysis sub-device according to the first background voltage value and the preset background voltage threshold, that is, according to the actual cleaning status of the immune analysis sub-device And the actual testing needs determine the cleaning mode, instead of just using a certain cleaning mode. In this way, on the basis of ensuring the cleaning effect, the precision of the device detection and the accuracy of the sample test results, in order to save specific cleaning liquids, Provide technical support to reduce the risk of contamination of specific cleaning fluids.
  • FIG. 1 is a schematic structural diagram of an embodiment of a sample analysis device of the present application.
  • FIG. 2 is a schematic structural diagram of another embodiment of a sample analysis device of the present application.
  • FIG. 3 is a schematic structural diagram of another embodiment of a sample analysis device of the present application.
  • FIG. 4 is a schematic flowchart of an embodiment of a cleaning method for a sample analysis device of the present application
  • FIG. 5 is a schematic flowchart of another embodiment of a cleaning method for a sample analysis device of the present application.
  • FIG. 6 is a schematic structural diagram of another embodiment of a sample analysis device of the present application.
  • FIG. 7 is a schematic structural diagram of another embodiment of a sample analysis device of the present application.
  • FIG. 1 is a schematic structural diagram of an embodiment of a sample analysis device of the present application.
  • the device includes: an immunoassay sub-device 1, a controller 2, and a cleaning subsystem 3.
  • the controller 2 is connected to the immune analysis sub-device 1 and is used to control the immune analysis sub-device 1 when there is no sample to be tested (where the sample to be tested can be whole blood, plasma, serum, diluted whole blood, plasma, serum, etc.)
  • the immunoassay sub-device 1 has three types of liquids to be added, including the soaking solution when it is not tested, the bottom solution and the sample to be tested in order, the soaking solution can be a conventional cleaning solution known to those skilled in the art, such as chloride Sodium, the first background voltage value refers to the voltage value obtained when only the bottom solution is added.
  • the bottom solution can be one, two, or three or more, such as latex reagents, which are mainly used for immune binding reactions with samples.) Detect its own first background voltage value (or current value), determine the cleaning mode of the immune analysis sub-device 1 according to the comparison between the first background voltage value and the preset background voltage threshold, and send a corresponding cleaning instruction.
  • the cleaning subsystem 3 is connected to the controller 2 and is configured to receive a cleaning instruction sent by the controller 2 and perform a corresponding cleaning on the immune analysis sub-device 1 in response to the cleaning instruction.
  • the immunoassay sub-device 1 is used for performing immunological analysis on a sample to be detected, for example, performing latex immunoassay and the like.
  • the first background voltage value is the background voltage value when the immune analysis sub-device 1 has no samples to be detected, and can represent the current cleaning state of the immune analysis sub-device 1.
  • the preset background voltage threshold may represent the actual testing requirements of the sample and / or the instrument, such as: the accuracy of the test result of the sample, the precision of the test of the instrument, and so on.
  • the preset background voltage threshold can be saved locally in advance, or input by the user, or imported locally from other places, and so on.
  • the cleaning subsystem 3 is connected to the controller 2. On the one hand, it receives a cleaning instruction sent by the controller 2, and on the other hand, responds to the cleaning instruction to perform corresponding cleaning on the immune analysis sub-device 1. If the original sample analysis device itself includes a part of the cleaning component, the composition of the cleaning subsystem 3 may include the part of the cleaning component, and the cleaning subsystem 3 may also include a new cleaning component. The specific composition needs to be determined according to the actual situation, which is not limited here. .
  • the sample analysis device includes an immune analysis sub-device, and further includes a controller connected to the immune analysis sub-device for controlling the first background of the immune analysis sub-device to detect itself when there is no sample to be detected.
  • a voltage value according to a comparison between the first background voltage value and a preset background voltage threshold to determine a cleaning mode of the immune analysis sub-device and send a corresponding cleaning instruction;
  • a cleaning subsystem connected to the controller Is configured to receive a cleaning instruction sent by the controller, and perform corresponding cleaning on the immune analysis sub-device in response to the cleaning instruction.
  • the cleaning mode of the immune analysis sub-device is determined and sent according to the comparison between the first background voltage value and the preset background voltage threshold.
  • Corresponding cleaning instructions to perform corresponding cleaning on the immune analysis sub-device and determine the cleaning mode of the immune analysis sub-device according to the first background voltage value and the preset background voltage threshold, that is, according to the actual cleaning status of the immune analysis sub-device And the actual testing needs determine the cleaning mode, instead of just using a certain cleaning mode. In this way, on the basis of ensuring the cleaning effect, the precision of the device detection and the accuracy of the sample test results, in order to save specific cleaning liquids, Provide technical support to reduce the risk of contamination of specific cleaning fluids.
  • the cleaning mode includes a first cleaning mode and a second cleaning mode.
  • the first cleaning mode refers to using the first cleaning solution to clean the immunoassay sub-device
  • the second cleaning mode refers to using the second cleaning solution to clean the immunological sub-device. Perform cleaning.
  • the first cleaning liquid is a conventional cleaning liquid
  • the second cleaning liquid is a dedicated cleaning liquid
  • the preset background voltage threshold can ensure the precision of the detection result of the immunoassay sub-device and the accuracy of the detection result of the sample to be detected. In this way, the cleaning cost can be saved on the basis of ensuring the accuracy of the detection result of the immunoassay sub-device and the accuracy of the detection result of the sample to be detected.
  • the preset background voltage threshold M is 90 millivolts, 95 millivolts, 100 millivolts, 105 millivolts, or 110 millivolts, and the specific values do not limit the present invention.
  • the rationality of limiting the preset background voltage threshold value M reduces the consumption of the special cleaning solution of the immunoassay sub-device, saves the reagent cost, reduces the risk of reagent contamination, the reliable cleaning effect, guarantees the accuracy of the results and the precision of the instrument .
  • the dedicated cleaning solution is a cleaning solution containing a hemolytic agent.
  • the controller 2 is specifically configured to control the immune analysis sub-device 1 to detect its first background voltage value when there is no sample to be detected later, and when the first background voltage value is less than a preset background voltage threshold value At this time, the controller controls the immune analysis sub-device 1 to detect the next sample to be detected, and determines that the cleaning mode of the immune analysis sub-device 1 after detecting the next sample to be detected is the first cleaning mode, and sends a corresponding first cleaning instruction
  • the cleaning subsystem 3 receives the first cleaning instruction sent by the controller 2 and responds to the first cleaning instruction to perform corresponding cleaning on the immune analysis sub-device 1 after the immune analysis sub-device 1 detects the next sample to be detected.
  • the controller 2 is further configured to determine that the cleaning mode of the immune analysis sub-device 1 is the second cleaning mode when the first background voltage value is greater than or equal to a preset background voltage threshold, and send a corresponding second cleaning instruction;
  • the system 3 receives the second cleaning instruction sent by the controller 2 and responds to the second cleaning instruction to perform corresponding cleaning on the immune analysis sub-device 1.
  • the device further includes a sample providing sub-device 4, an immunological reagent supplying device 5, a first cleaning liquid storage sub-device 6 and a second cleaning liquid storage sub-device 7.
  • the sample supply sub-device 4 is connected to the controller 2, the immune reagent supply device 5 is connected to the controller 2 and the immunoassay sub-device 1, respectively, and the first cleaning liquid storage sub-device 6 and the second cleaning liquid storage sub-device 7 are both connected to the sample supply.
  • the sub-device 4 is connected; the sample providing sub-device 4 provides the sample to be analyzed to the immuno-analytical sub-device 1 under the control of the controller 2, or supplies the first cleaning solution in the first cleaning solution storage sub-device 6 to the immuno-analytical component.
  • the apparatus 1 is used for cleaning, or the second cleaning solution in the second cleaning solution storage sub-device 7 (for storing the second cleaning solution required for cleaning the immunoassay sub-device 1) is provided to the immunoassay sub-device 1 for Cleaning; the immunological reagent supply sub-device 5 provides the immunological analysis sub-device 1 with the required immunological reagents (eg, hemolytic agent, latex reagent, etc.) under the control of the controller 2.
  • the second cleaning liquid storage sub-device 7 is disposed on the walking path of the sample providing sub-device 4.
  • the sample providing sub-device 4 and the first cleaning liquid storage sub-device 6 can be regarded as the structure of the original sample analysis device itself.
  • the second cleaning liquid storage sub-device 7 is added to the original structure, but still The second cleaning liquid in the second cleaning liquid storage sub-device 7 is provided to the immunoassay sub-device 1 for cleaning by using the sample providing sub-device 4. That is, the cleaning subsystem actually includes the sample providing sub-device 4, the first cleaning liquid storage sub-device 6, and the second cleaning liquid storage sub-device 7.
  • Structural components on the other hand, can make the structure of the sample analysis device as compact as possible.
  • the device further includes a sample providing sub-device 4, an immunoreagent supplying sub-device 5, a second cleaning liquid supplying sub-device 8, a first cleaning liquid storage sub-device 6, and a second cleaning liquid.
  • the sample supply sub-device 4 is connected to the controller 2, the immune reagent supply sub-device 5 is connected to the controller 2 and the immunoassay sub-device 1, respectively, and the second cleaning solution supply sub-device 8 (including a pipeline, a valve, a syringe, or a quantitative pump, etc.)
  • the fluid path components (familiar to those skilled in the art) are connected to the controller 2 and the immunoassay sub-device 1, respectively, the first cleaning liquid storage sub-device 6 is connected to the sample providing sub-device 4, and the second cleaning liquid storage sub-device 7 is connected to the second The cleaning liquid supply sub-device 8 is connected; under the control of the controller 2, the sample supply sub-device 4 provides the sample to be detected to the immunoassay sub-device 1 or the first cleaning liquid in the first cleaning liquid storage sub-device 6 is provided to The immunoassay sub-device 1 is used for cleaning; the second washing liquid supply sub-device 8 provides the second washing solution in the second washing liquid
  • the sample providing sub-device 4 and the first cleaning liquid storage sub-device 6 can be regarded as the structure of the original sample analysis device itself.
  • the second cleaning liquid supply sub-device 8 and the second are added to the structure.
  • the cleaning liquid storage sub-device 7 does not use the sample providing sub-device 4 but uses a newly added second cleaning liquid supply sub-device 8 to supply the second cleaning liquid in the second cleaning liquid storage sub-device 7 to the immunoassay sub-device. 1 for cleaning. That is, the cleaning subsystem actually includes a sample supply sub-device 4, a first cleaning liquid storage sub-device 6, a second cleaning liquid supply sub-device 8, and a second cleaning liquid storage sub-device 7. In this way, sample analysis can be performed The modification of the device is as small as possible, and the original sample analysis device is easily and conveniently modified.
  • sample providing sub-device 4 includes a sampling needle, a driving assembly, and a pipeline.
  • FIG. 4 is a schematic flowchart of an embodiment of a method for cleaning a sample analysis device of the present application. This method is applicable to the sample analysis device of any one of the above. For a detailed description of the related content, please refer to the above device section, To repeat.
  • the method includes:
  • Step S101 Control the immune analysis sub-device to detect its first background voltage value when there is no sample to be detected.
  • Step S102 According to the first background voltage value and the preset background voltage threshold, a cleaning mode of the immune analysis sub-device is determined and a corresponding cleaning instruction is sent.
  • Step S103 Perform corresponding cleaning on the immunoassay sub-device in response to the cleaning instruction.
  • the embodiment of the present application controls the immunoassay sub-device to detect its own first background voltage value when there is no sample to be detected; the cleaning of the immunoassay sub-device is determined according to the comparison between the first background voltage value and the preset background voltage threshold. Mode and send corresponding cleaning instructions; respond to the cleaning instructions and perform corresponding cleaning on the immunoassay sub-device.
  • the cleaning mode of the immune analysis sub-device is determined according to the comparison between the first background voltage value and the preset background voltage threshold, and a corresponding A cleaning instruction to perform corresponding cleaning on the immune analysis sub-device, and determine the cleaning mode of the immune analysis sub-device according to the first background voltage value and a preset background voltage threshold, that is, according to the actual cleaning status of the immune analysis sub-device and the actual
  • the detection needs determine the cleaning mode, instead of only using a certain cleaning mode. In this way, on the basis of ensuring the cleaning effect, the precision of the device detection and the accuracy of the sample test results, in order to save specific cleaning liquids and reduce specific Provide technical support for the risk of cleaning fluid contamination.
  • the cleaning mode includes a first cleaning mode and a second cleaning mode.
  • the first cleaning mode refers to using the first cleaning solution to clean the immunoassay sub-device
  • the second cleaning mode refers to using the second cleaning solution to clean the immunological sub-device. Perform cleaning.
  • the first cleaning liquid is a conventional cleaning liquid
  • the second cleaning liquid is a special cleaning liquid
  • the preset background voltage threshold M is 90 millivolts, 95 millivolts, 100 millivolts, 105 millivolts, or 110 millivolts, and the specific values do not limit the present invention.
  • the special cleaning solution is a cleaning solution containing a hemolytic agent.
  • the hemolysing agent may contain a quaternary ammonium salt cationic surfactant to dissolve red blood cells, and the liquid containing the hemolysing agent component may be directly used to wash the reaction residue of the immunoassay sub-device; in addition, the liquid containing the hemolyzing agent component is a common method in sample analysis. Liquid, so there is no need to prepare other special cleaning liquid, which can simplify the process and further save reagent costs.
  • the step S101 controls the immune analysis sub-device to detect its own first background voltage value when there is no sample to be detected, which specifically includes: controlling the immune analysis sub-device to detect its own first value after the sample has been cleaned and measured, and there is no sample to be detected Background voltage value; step S102 determines the cleaning mode of the immunoassay sub-device and sends a corresponding cleaning instruction according to the comparison between the first background voltage value and a preset background voltage threshold value stored locally, and specifically includes: when the first When the background voltage value is less than the preset background voltage threshold, the cleaning mode of the immunoassay sub-device is determined to be the first cleaning mode, and a corresponding first cleaning instruction is sent.
  • step S103 responds to the cleaning instruction and performs corresponding cleaning on the immune analysis sub-device, which may specifically include: A corresponding cleaning instruction is performed on the immunoassay sub-device, or in response to a second cleaning instruction Analyzing means corresponding to the sub-cleaning.
  • the step S101 controls the immune analysis sub-device to detect its own background voltage value when there is no sample to be detected, which specifically includes: controlling the immune analysis sub-device to detect its second background voltage before the sample is detected and when there is no sample to be detected
  • Step S102 determines the cleaning mode of the immunoassay sub-device and sends a corresponding cleaning instruction according to the comparison between the background voltage value and the preset background voltage threshold, which may specifically include: when the second background voltage value is less than the preset background voltage When the threshold voltage is set, the cleaning mode of the immune analysis sub-device is determined to be the first cleaning mode, and a corresponding first cleaning command is sent.
  • the second background voltage value is greater than or equal to a preset background voltage threshold, the immune analysis is determined.
  • the cleaning mode of the sub-device is the second cleaning mode, and a corresponding second cleaning instruction is sent; step S103 responds to the cleaning instruction and performs corresponding cleaning on the immune analysis sub-device, which may specifically include: responding to the first cleaning instruction, the immune analysis sub-device Corresponding cleaning of the device, or corresponding immunoassay sub-device in response to the second cleaning instruction Cleaning.
  • the corresponding cleaning of the immune analysis sub-device in response to the first cleaning instruction or the corresponding cleaning of the immune analysis sub-device in response to the second cleaning instruction may specifically include:
  • the sample supply sub-device is controlled in response to the first cleaning instruction to supply the first cleaning solution in the first cleaning liquid storage sub-device to the immunoassay sub-device for cleaning, or the control sample supply sub-device is controlled to respond to the second cleaning instruction.
  • the second cleaning solution in the two cleaning solution storage sub-devices is provided to the immunoassay sub-device for cleaning.
  • the corresponding cleaning of the immune analysis sub-device in response to the first cleaning instruction or the corresponding cleaning of the immune analysis sub-device in response to the second cleaning instruction may specifically include:
  • the apparatus supplies the second cleaning solution in the second cleaning solution storage sub-device to the immunoassay sub-device for cleaning.
  • Step S201 switch the immune analysis mode to detect the first background voltage value in the immune analysis sub-device
  • Step S202 determine whether the first background voltage value of the immune analysis sub-device is less than a defined preset background voltage threshold M;
  • Step S203 If the first background voltage value is less than the preset background voltage threshold M, the sample providing sub-device 1 is allowed to perform collection of the sample to be detected and provide the sample to be detected to the immune analysis sub-device, and the immune analysis sub-device performs sample analysis Drain the sample solution and wash it with conventional diluent (ie, the first cleaning solution);
  • Step S204 After detecting the sample, continue to detect the first background voltage value in the immune analysis sub-device, and return to step S202;
  • Step S205 if the first background voltage value of step S202 is greater than or equal to the preset background voltage threshold M, the sample providing sub-device sucks the special cleaning from the special cleaning liquid storage sub-device (ie, the second cleaning liquid storage sub-device) The liquid is transferred to the immunoassay sub-device for cleaning;
  • Step S206 After the cleaning is finished, continue to detect the first background voltage value and return to step S202.
  • the rationality of limiting the preset background voltage threshold M reduces the consumption of the special cleaning solution for the immunoassay sub-device, saves the cost of reagents, reduces the risk of reagent contamination, the reliable cleaning effect, and ensures the accuracy of the test results and the instrument of the sample Requirements for precision of test results.
  • an embodiment of the present invention further provides a sample analysis device.
  • the sample analysis device includes an immune analysis sub-device 11, a controller 21, and a cleaning subsystem 31.
  • the immunoassay sub-device 11 includes a colorimetric cell 12 and lasers 14 and photoelectric receivers 13 respectively disposed on both sides of the colorimetric cell 12.
  • the colorimetric cell 12 is used for installing immersion when not detecting. Liquid, the colorimetric cell 12 is used for discharging the soaking liquid and sequentially installing a bottom liquid and a sample to be tested during the detection, and the laser 14 is configured to emit a laser toward the colorimetric cell 12 to make the photoelectric
  • the receiver 13 obtains an optical signal and converts it into an electrical signal, wherein the electrical signal obtained when the photoelectric receiver 13 discharges the soaking solution and only contains the bottom liquid is the first background electrical signal
  • the controller 21 is configured to receive the first background electrical signal, compare the first background electrical signal with a preset background electrical signal, and issue a corresponding cleaning instruction; the cleaning subsystem 31 is configured to: The corresponding colorimetric cell is cleaned in response to the cleaning instruction, wherein:
  • the controller 21 issues a first cleaning instruction to cause the cleaning subsystem 11 to perform a first cleaning solution on the colorimetric cell.
  • the controller 21 issues a second cleaning instruction so that the cleaning subsystem 11 uses a second cleaning liquid to compare the colorimetric
  • the cleaning is performed in a pool, wherein the cleaning strength of the second cleaning liquid to the specific substance is greater than that of the first cleaning liquid to the specific substance.
  • the specific substance may be a conjugate or a reaction residue of an immune response.
  • the sample analysis device provided in this embodiment can perform sample detection when a bottom liquid and a sample to be tested are sequentially installed in the cuvette 12, and use the state when only the bottom liquid is installed in the cuvette 12 to determine whether a special cleaning is required.
  • Liquid cleaning is different from the conventional method of cleaning or quantifying (such as every 100 samples) with a special cleaning solution at regular intervals (for example, every one hour).
  • This embodiment provides The device can more accurately determine whether it is necessary to use a special cleaning liquid for cleaning, thereby achieving the purpose of intelligently triggering the special cleaning liquid for cleaning and saving the special cleaning liquid.
  • an embodiment of the present invention further provides a sample analysis device.
  • the sample analysis device includes a container 25, a photoelectric detection component 23, and a controller 22.
  • the container 25 is used to hold at least the bottom liquid and the sample to be tested; the photoelectric detection component 23 is used to perform detection when the container 25 only holds the bottom liquid to obtain a first background electrical signal, and 25 A sample detection electrical signal is obtained when the base liquid and the sample to be tested are contained; the controller 22 is configured to issue a first instruction to the first background electrical signal when the first background electrical signal is less than a preset background electrical signal threshold.
  • the container is cleaned or not cleaned in the first cleaning mode, otherwise a second instruction is issued to the container to perform the cleaning in the second cleaning mode, and the cleaning intensity of the specific substance in the second cleaning mode is greater than that of the container.
  • the first cleaning mode is the cleaning strength of specific substances.
  • the first cleaning mode and the second cleaning mode may be performed by the cleaning subsystem 32. For the specific configuration of the cleaning subsystem 32, reference may be made to the foregoing embodiment, and details are not described in this embodiment.
  • the container 25 may be the colorimetric cell 12 or other reaction cells in the foregoing embodiment.
  • the components of the bottom liquid and the sample to be tested include, but are not limited to those described in the above embodiments, as long as the detection is performed by sequentially adding liquids. , You can judge whether you need to enable the second type of cleaning by comparing the size of the first background electrical signal with the preset background electrical signal in the intermediate state (that is, the state with one, two, or three or more base liquids added). mode.
  • the first background electrical signal is obtained by detecting when the container 25 only contains the bottom liquid, and this is used as a trigger condition for determining whether a special cleaning liquid is needed for cleaning, which can improve the cleaning efficiency and ensure that Requirements for accuracy of sample test results and precision of instrument test results.

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Abstract

一种样本分析装置及其清洗方法，装置包括：免疫分析子装置(1)，还包括控制器(2)，与免疫分析子装置(1)连接，用于控制免疫分析子装置(1)在没有待检测样本时检测自身的第一本底电压值，根据第一本底电压值和预设本底电压阈值的大小比较来确定免疫分析子装置(1)的清洗模式并发送对应的清洗指令；清洗子系统(3)，与控制器(2)连接，用于接收控制器(2)发送的清洗指令，并响应清洗指令而对免疫分析子装置(1)进行对应的清洗。上述方式能够在保证清洁效果、装置检测精密度以及样本检测结果准确性的基础上，为节约特定清洗液、降低特定清洗液污染的风险提供技术支持。

Description

样本分析装置及其清洗方法 【技术领域】
本申请涉及免疫分析技术领域，特别是涉及一种样本分析装置及其清洗方法。
【背景技术】
免疫分析装置是利用乳胶免疫反应试剂与待检测样本进行乳胶免疫反应，利用激光散射或者透射的检测方法，从而完成乳胶免疫分析。为了利于免疫分析装置的维护和再使用，延长免疫分析装置的使用周期及保证样本分析结果的可靠性，通常需要对免疫分析装置进行清洗。
在现有技术中，使用血常规溶血剂或者血常规反应后的试液对免疫分析装置进行清洗，即每一次乳胶免疫分析反应及分析后，都对免疫分析装置进行清洗。但是，本申请的发明人在长期的研发过程中发现，上述清洗方法有以下缺陷：一是血常规溶血剂的耗量将增加，成本将大大增加，二是血常规溶血剂一般相比免疫溶血试剂的溶血能力更强，且每次使用血常规溶血剂或者血常规反应后的试液进行冲洗，增加了对乳胶免疫试剂污染的风险，从而造成结果的不可靠。
【发明内容】
本申请主要解决的技术问题是提供一种样本分析装置及其清洗方法，能够在保证清洁效果、装置检测精密度以及样本检测结果准确性的基础上，为节约特定清洗液、降低特定清洗液污染的风险提供技术支持。
为解决上述技术问题，本申请采用的一个技术方案是：提供一种样本分析装置，所述样本分析装置包括免疫分析子装置，所述装置还包括：控制器，与所述免疫分析子装置连接，用于控制所述免疫分析子装置在没有待检测样本时检测自身的第一本底电压值，根据所述第一本底电压值和预设本底电压阈值的大小比较来确定所述免疫分析子装置的清洗模式并发送对应的清洗指令；清洗子系统，与所述控制器连接，用于接收所述控制器发送的清洗指令，并响应所述清洗指令而对所述免疫分析子装置进行对应的清洗。
为解决上述技术问题，本申请采用的另一个技术方案是：提供一种样本分析装置的清洗方法，所述方法适用于如上所述的样本分析装置，所述方法包括：控制所述免疫分析子装置在没有待检测样本时检测自身的第一本底电压值；根据所述第一本底电压值和预设本底电压阈值的大小比较来确定所述免疫分析子装置的清洗模式并发送对应的清洗指令；响应所述清洗指令而对所述免疫分析子装置进行对应的清洗。
为解决上述技术问题，本申请采用的另一个技术方案是：提供一种样本分析装置，所述样本分析装置包括：
免疫分析子装置，所述免疫分析子装置包括比色池及分别设于所述比色池两侧的激光器和光电接收器，所述比色池在不作检测时用于装设浸泡液，所述比色池在进行检测时用于排出所述浸泡液并依次装设底液和待检测样本，所述激光器用于朝向所述比色池发出激光以使得所述光电接收器获得光信号并转化为电信号，其中所述光电接收器在所述比色池排出所述浸泡液并仅装有所述底液时获得的电信号为第一本底电信号；
控制器，用于接收所述第一本底电信号，并将所述第一本底电信号与预设本底电信号作比较并发出对应的清洗指令。
为解决上述技术问题，本申请采用的另一个技术方案是：提供一种样本分析装置，包括：
容器，至少用于盛放底液和待检测样本；
光电检测组件，用于在所述容器仅盛放所述底液时进行检测而得到第一本底电信号，在所述容器盛放所述底液和待检测样本时进行检测而得到样本检测电信号；
控制器，用于在所述第一本底电信号小于预设本底电信号阈值时发出第一指令以对所述容器进行第一种清洗模式的清洗或不清洗，否则发出第二指令对所述容器以进行第二种清洗模式的清洗，所述第二种清洗模式对特定物质的清洁强度大于所述第一种清洗模式对特定物质的清洁强度。
本申请的有益效果是：区别于现有技术的情况，本申请样本分析装置包括免疫分析子装置，还包括：控制器，与所述免疫分析子装置连接，用于控制所述免疫分析子装置在没有待检测样本时检测自身的第一本底电压值，根据所述第一本底电压值和预设本底电压阈值的大小比较来确定所述免疫分析子装置的 清洗模式并发送对应的清洗指令；清洗子系统，与所述控制器连接，用于接收所述控制器发送的清洗指令，并响应所述清洗指令而对所述免疫分析子装置进行对应的清洗。由于该装置在没有待检测样本时检测免疫分析子装置的第一本底电压值，根据第一本底电压值和预设本底电压阈值的大小比较来确定免疫分析子装置的清洗模式并发送对应的清洗指令，以对免疫分析子装置进行对应的清洗，根据第一本底电压值和预设本底电压阈值，确定免疫分析子装置的清洗模式，即根据免疫分析子装置的实际清洁状态以及实际检测需求确定清洗模式，而不是只固定采用某一清洗模式清洗，通过这种方式，能够在保证清洁效果、装置检测精密度以及样本检测结果准确性的基础上，为节约特定清洗液、降低特定清洗液污染的风险提供技术支持。
【附图说明】
为了更清楚地说明本申请实施例中的技术方案，下面将对实施例描述中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图仅仅是本申请的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他的附图。其中：
图1是本申请样本分析装置一实施方式的结构示意图；
图2是本申请样本分析装置另一实施方式的结构示意图；
图3是本申请样本分析装置又一实施方式的结构示意图；
图4是本申请样本分析装置的清洗方法一实施方式的流程示意图；
图5是本申请样本分析装置的清洗方法另一实施方式的流程示意图；
图6是本申请样本分析装置另一实施方式的结构示意图；
图7是本申请样本分析装置另一实施方式的结构示意图。
【具体实施方式】
下面将结合本申请实施例中的附图，对本申请实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本申请一部分实施例，而不是全部实施例。基于本申请中的实施例，本领域普通技术人员在没有做出创造性的劳动前提下所获得的所有其他实施例，都属于本申请保护的范围。
参阅图1，图1是本申请样本分析装置一实施方式的结构示意图，该装置包括：免疫分析子装置1、控制器2以及清洗子系统3。
控制器2与免疫分析子装置1连接，用于控制免疫分析子装置1在没有待检测样本(其中待检测样本可以是全血、血浆、血清、稀释后的全血、血浆、血清等)时(其中免疫分析子装置1会有三类液体加入，包括不检测时的浸泡液，检测时依次加入的底液和待检测样本，浸泡液可以采用本领域技术人员熟知的常规清洗液，如氯化钠，第一本底电压值特指仅有底液加入时获得的电压值，底液可以是一种、两种或三种及以上，例如乳胶试剂，主要用于与样本发生免疫结合反应)检测自身的第一本底电压值(或电流值)，根据第一本底电压值和预设本底电压阈值的大小比较来确定免疫分析子装置1的清洗模式并发送对应的清洗指令。
清洗子系统3与控制器2连接，用于接收控制器2发送的清洗指令，并响应清洗指令而对免疫分析子装置1进行对应的清洗。
免疫分析子装置1用于对待检测样本进行免疫分析，例如进行胶乳免疫分析等。第一本底电压值即为免疫分析子装置1没有待检测样本时的本底电压值，可以代表免疫分析子装置1当前的清洁状态。预设本底电压阈值可以代表样本和/或仪器的实际检测需求，例如：样本的检测结果准确性，仪器的检测精密度，等等。预设本底电压阈值可以预先保存在本地，或者用户输入，或者从其他地方导入本地，等等。
清洗子系统3与控制器2连接，一方面接收控制器2发送的清洗指令，另一方面响应该清洗指令对免疫分析子装置1进行对应的清洗。如果原样本分析装置本身包括一部分清洗组件，那么清洗子系统3的构成可以包括该部分清洗组件，清洗子系统3还可以包括新的清洗组件，具体构成需要依据实际情况确定，在此不做限定。
本申请实施方式样本分析装置包括免疫分析子装置，还包括：控制器，与所述免疫分析子装置连接，用于控制所述免疫分析子装置在没有待检测样本时检测自身的第一本底电压值，根据所述第一本底电压值和预设本底电压阈值的大小比较来确定所述免疫分析子装置的清洗模式并发送对应的清洗指令；清洗子系统，与所述控制器连接，用于接收所述控制器发送的清洗指令，并响应所述清洗指令而对所述免疫分析子装置进行对应的清洗。由于该装置在没有待检测样本时检测免疫分析子装置的第一本底电压值，根据第一本底电压值和预设本底电压阈值的大小比较来确定免疫分析子装置的清洗模式并发送对应的清洗 指令，以对免疫分析子装置进行对应的清洗，根据第一本底电压值和预设本底电压阈值，确定免疫分析子装置的清洗模式，即根据免疫分析子装置的实际清洁状态以及实际检测需求确定清洗模式，而不是只固定采用某一清洗模式清洗，通过这种方式，能够在保证清洁效果、装置检测精密度以及样本检测结果准确性的基础上，为节约特定清洗液、降低特定清洗液污染的风险提供技术支持。
其中，清洗模式包括第一清洗模式和第二清洗模式，第一清洗模式是指采用第一清洗液对免疫分析子装置进行清洗，第二清洗模式是指采用第二清洗液对免疫分析子装置进行清洗。
进一步，第一清洗液是常规清洗液，第二清洗液是专用清洗液。
常规清洗液一般价格比较便宜，专用清洗液价格比较昂贵，根据不同的清洗模式，分别采用不同的清洗液对免疫分析子装置进行清洗，可以在满足用户需求的基础上，节约专用清洗液的使用量，从而节约清洗成本。预设本底电压阈值可以保证免疫分析子装置的检测结果精密度和待检测样本的检测结果准确性。通过这种方式，可以在保证免疫分析子装置的检测结果精密度和待检测样本的检测结果准确性基础上，节约清洗成本。
其中，在一实施方式中，预设本底电压阈值M为90毫伏、95毫伏、100毫伏、105毫伏或110毫伏等，具体数值不构成对本发明的限定。
限定预设本底电压阈值M的合理性减少了对免疫分析子装置的专用清洁液的消耗，节约试剂成本，降低试剂污染的风险，清洁效果可靠，保证结果的准确性和仪器精密度的要求。
在一实施方式中，专用清洗液为含溶血剂的清洗液。
在一实施方式中，控制器2具体用于控制免疫分析子装置1在后、没有待检测样本时检测自身的第一本底电压值，当第一本底电压值小于预设本底电压阈值时，控制器控制免疫分析子装置1检测下一个待检测样本，并确定免疫分析子装置1在检测完下一个待检测样本后的清洗模式为第一清洗模式，并发送对应的第一清洗指令；清洗子系统3接收控制器2发送的第一清洗指令，并响应第一清洗指令而在免疫分析子装置1检测完下一个待检测样本后对免疫分析子装置1进行对应的清洗。
控制器2还用于当第一本底电压值大于或等于预设本底电压阈值时，确定免疫分析子装置1的清洗模式为第二清洗模式，并发送对应的第二清洗指令； 清洗子系统3接收控制器2发送的第二清洗指令，并响应第二清洗指令而对免疫分析子装置1进行对应的清洗。
请参见图2，在一实施方式中，该装置还包括样本提供子装置4、免疫试剂供给装置5、第一清洗液存储子装置6以及第二清洗液存储子装置7。
样本提供子装置4与控制器2连接，免疫试剂供给装置5分别与控制器2和免疫分析子装置1连接，第一清洗液存储子装置6和第二清洗液存储子装置7均与样本提供子装置4连接；样本提供子装置4在控制器2的控制下，向免疫分析子装置1提供待分析样本，或者将第一清洗液存储子装置6中的第一清洗液提供给免疫分析子装置1以进行清洗，或者将第二清洗液存储子装置7(用于存储清洗免疫分析子装置1所需的第二清洗液，)中的第二清洗液提供给免疫分析子装置1以进行清洗；免疫试剂供给子装置5在控制器2的控制下，向免疫分析子装置1提供检测待分析样本所需的免疫试剂(例如：溶血剂、乳胶试剂，等等)。其中，第二清洗液存储子装置7设置在样本提供子装置4的行走路径上。
在本实施方式中，样本提供子装置4和第一清洗液存储子装置6可以当做是原始样本分析装置本身具有的结构，在原有结构的基础上增加了第二清洗液存储子装置7，依然利用样本提供子装置4将第二清洗液存储子装置7中的第二清洗液提供给免疫分析子装置1以进行清洗。即，清洗子系统实际上包括样本提供子装置4、第一清洗液存储子装置6和第二清洗液存储子装置7，通过这种方式，一方面可以充分复用原始样本分析装置已有的结构部件，另一方面可以使得样本分析装置的结构尽可能紧凑。
请参见图3，在一实施方式中，该装置还包括样本提供子装置4、免疫试剂供给子装置5、第二清洗液供给子装置8、第一清洗液存储子装置6以及第二清洗液存储子装置7。
样本提供子装置4与控制器2连接，免疫试剂供给子装置5分别与控制器2和免疫分析子装置1连接，第二清洗液供给子装置8(包括管路、阀门、注射器或定量泵等本领域技术人员熟知的液路元件)分别与控制器2和免疫分析子装置1连接，第一清洗液存储子装置6与样本提供子装置4连接，第二清洗液存储子装置7与第二清洗液供给子装置8连接；样本提供子装置4在控制器2的控制下，向免疫分析子装置1提供待检测样本，或者将第一清洗液存储子装置6中的第一清洗液提供给免疫分析子装置1以进行清洗；第二清洗液供给子装置8 在控制器2的控制下，将第二清洗液存储子装置7中的第二清洗液提供给免疫分析子装置1以进行清洗；免疫试剂供给子装置5在控制器2的控制下，向免疫分析子装置1提供检测待检测样本所需的免疫试剂。其中，第二清洗液存储子装置7设置在样本分析装置的内部或者外部。
在本实施方式中，样本提供子装置4和第一清洗液存储子装置6可以当做是原始样本分析装置本身具有的结构，在结构的基础上增加了第二清洗液供给子装置8和第二清洗液存储子装置7，没有利用样本提供子装置4，而是利用新增加的第二清洗液供给子装置8将第二清洗液存储子装置7中的第二清洗液提供给免疫分析子装置1以进行清洗。即，清洗子系统实际上包括样本提供子装置4、第一清洗液存储子装置6、第二清洗液供给子装置8和第二清洗液存储子装置7，通过这种方式，可以使得样本分析装置的改动尽可能小，简单便利地改造原始样本分析装置。
进一步，样本提供子装置4包括采样针、驱动组件及管路。
参见图4，图4是本申请样本分析装置的清洗方法一实施方式的流程示意图，该方法适用于如上任一项的样本分析装置，相关内容的详细说明请参见上述装置部分，在此不再赘叙。该方法包括：
步骤S101：控制免疫分析子装置在没有待检测样本时检测自身的第一本底电压值。
步骤S102：根据第一本底电压值和预设本底电压阈值，确定免疫分析子装置的清洗模式并发送对应的清洗指令。
步骤S103：响应清洗指令而对免疫分析子装置进行对应的清洗。
本申请实施方式控制免疫分析子装置在没有待检测样本时检测自身的第一本底电压值；根据第一本底电压值和预设本底电压阈值的大小比较来确定免疫分析子装置的清洗模式并发送对应的清洗指令；响应清洗指令而对免疫分析子装置进行对应的清洗。由于在没有待检测样本时检测免疫分析子装置的第一本底电压值，根据第一本底电压值和预设本底电压阈值的大小比较来确定免疫分析子装置的清洗模式并发送对应的清洗指令，以对免疫分析子装置进行对应的清洗，根据第一本底电压值和预设本底电压阈值，确定免疫分析子装置的清洗模式，即根据免疫分析子装置的实际清洁状态以及实际检测需求确定清洗模式，而不是只固定采用某一清洗模式清洗，通过这种方式，能够在保证清洁效果、 装置检测精密度以及样本检测结果准确性的基础上，为节约特定清洗液、降低特定清洗液污染的风险提供技术支持。
其中，清洗模式包括第一清洗模式和第二清洗模式，第一清洗模式是指采用第一清洗液对免疫分析子装置进行清洗，第二清洗模式是指采用第二清洗液对免疫分析子装置进行清洗。
其中，第一清洗液是常规清洗液，第二清洗液是专用清洗液。
其中，预设本底电压阈值M为90毫伏、95毫伏、100毫伏、105毫伏或110毫伏等，具体数值不构成对本发明的限定。
其中，专用清洗液为含溶血剂的清洗液。溶血剂中可以含有季铵盐阳离子表面活性剂来溶解红细胞，可以直接使用含有溶血剂成分的液体来清洗免疫分析子装置的反应残留物；另外，含有溶血剂成分的液体是样本分析中的常见液体，因此无需专门准备其它的专用清洗液，可以简化工序，进一步节约试剂成本。
其中，步骤S101控制免疫分析子装置在没有待检测样本时检测自身的第一本底电压值，具体可以包括：控制免疫分析子装置在清洗样本测量后、没有待检测样本时检测自身的第一本底电压值；步骤S102根据第一本底电压值和本地保存的预设本底电压阈值的大小比较来确定免疫分析子装置的清洗模式并发送对应的清洗指令，具体可以包括：当第一本底电压值小于预设本底电压阈值时，则确定免疫分析子装置的清洗模式为第一清洗模式，并发送对应的第一清洗指令，当第一本底电压值大于或等于预设本底电压阈值时，确定免疫分析子装置的清洗模式为第二清洗模式，并发送对应的第二清洗指令；步骤S103响应清洗指令而对免疫分析子装置进行对应的清洗，具体可以包括：响应第一清洗指令而对免疫分析子装置进行对应的清洗，或，响应第二清洗指令而对免疫分析子装置进行对应的清洗。
其中，步骤S101控制免疫分析子装置在没有待检测样本时检测自身的本底电压值，具体可以包括：控制免疫分析子装置在样本检测之前、没有待检测样本时检测自身的第二本底电压值；步骤S102根据本底电压值和预设本底电压阈值的大小比较来确定免疫分析子装置的清洗模式并发送对应的清洗指令，具体可以包括：当第二本底电压值小于预设本底电压阈值时，则确定免疫分析子装置的清洗模式为第一清洗模式，并发送对应的第一清洗指令，当第二本底电压 值大于或等于预设本底电压阈值时，确定免疫分析子装置的清洗模式为第二清洗模式，并发送对应的第二清洗指令；步骤S103响应清洗指令而对免疫分析子装置进行对应的清洗，具体可以包括：响应第一清洗指令而对免疫分析子装置进行对应的清洗，或，响应第二清洗指令而对免疫分析子装置进行对应的清洗。
进一步，响应第一清洗指令而对免疫分析子装置进行对应的清洗，或，响应第二清洗指令而对免疫分析子装置进行对应的清洗，具体可以包括：
响应第一清洗指令而控制样本提供子装置将第一清洗液存储子装置中的第一清洗液提供给免疫分析子装置以进行清洗，或者，响应第二清洗指令而控制样本提供子装置将第二清洗液存储子装置中的第二清洗液提供给免疫分析子装置以进行清洗。
进一步，响应第一清洗指令而对免疫分析子装置进行对应的清洗，或，响应第二清洗指令而对免疫分析子装置进行对应的清洗，具体可以包括：
响应第一清洗指令而控制样本提供子装置将第一清洗液存储子装置中的第一清洗液提供给免疫分析子装置以进行清洗；或者，响应第二清洗指令而控制第二清洗液供给子装置将第二清洗液存储子装置中的第二清洗液提供给免疫分析子装置以进行清洗。
例如，参见图5，在一实际应用中，上述方法的具体实施步骤可以是：
步骤S201：切换免疫分析模式，以检测免疫分析子装置中的第一本底电压值；
步骤S202：判断免疫分析子装置的第一本底电压值是否小于限定的预设本底电压阈值M；
步骤S203：若第一本底电压值小于预设本底电压阈值M时，则允许样本提供子装置1执行采集待检测样本并提供待检测样本给免疫分析子装置，免疫分析子装置进行样本分析后排掉样本液并进行常规稀释液(即第一清洗液)清洗；
步骤S204：样本检测完之后继续检测免疫分析子装置中的第一本底电压值，并返回步骤S202；
步骤S205：若步骤S202的第一本底电压值大于或等于预设本底电压阈值M时，由样本提供子装置从专用清洗液存储子装置(即第二清洗液存储子装置)吸取专用清洗液并输送至免疫分析子装置中进行清洗；
步骤S206：清洗结束后，继续检测第一本底电压值并返回步骤S202。
限定预设本底电压阈值M的合理性减少了对免疫分析子装置的专用清洁液的消耗，节约试剂成本，降低了试剂污染的风险，清洁效果可靠，保证了样本检测结果的准确性和仪器检测结果精密度的要求。
请参见图6，本发明实施例还提供一种样本分析装置，该样本分析装置包括免疫分析子装置11、控制器21以及清洗子系统31。
其中，所述免疫分析子装置11包括比色池12及分别设于所述比色池12两侧的激光器14和光电接收器13，所述比色池12在不作检测时用于装设浸泡液，所述比色池12在进行检测时用于排出所述浸泡液并依次装设底液和待检测样本，所述激光器14用于朝向所述比色池12发出激光以使得所述光电接收器13获得光信号并转化为电信号，其中所述光电接收器13在所述比色池排出所述浸泡液并仅装有所述底液时获得的电信号为第一本底电信号；控制器21用于接收所述第一本底电信号，并将所述第一本底电信号与预设本底电信号作比较并发出对应的清洗指令；所述清洗子系统31用于响应所述清洗指令而对所述比色池进行对应的清洗，其中：
当所述第一本底电信号小于所述预设本底电信号时，所述控制器21发出第一清洗指令以使得所述清洗子系统11采用第一清洗液对所述比色池进行清洗；
当所述第一本底电信号大于或等于所述预设本底电信号时，所述控制器21发出第二清洗指令以使得所述清洗子系统11采用第二清洗液对所述比色池进行清洗，其中所述第二清洗液对特定物质的清洁强度大于所述第一清液液对所述特定物质的清洁强度。所述特定物质可以是免疫反应的结合物或者反应残留物。
本实施例提供的样本分析装置在比色池12内依次装设底液和待检测样本时可进行样本检测，并利用比色池12内仅装有底液时的状态判断是否需要采用专用清洗液进行清洗，不同于现有技术中定时(例如每隔一小时洗一次)采用专用清洗液进行清洗或定量(例如每100支样本洗一次)采用专用清洗液进行清洗的方式，本实施例提供的装置更能够准确的判断是否需要采用专用清洗液进行清洗，从而达到智能触发专用清洗液进行清洗、节约专用清洗液的目的。
请参见图7，本发明实施例还提供一种样本分析装置，该样本分析装置包括容器25、光电检测组件23以及控制器22。
其中，容器25至少用于盛放底液和待检测样本；光电检测组件23用于在所述容器25仅盛放所述底液时进行检测而得到第一本底电信号，在所述容器25 盛放所述底液和待检测样本时进行检测而得到样本检测电信号；控制器22用于在所述第一本底电信号小于预设本底电信号阈值时发出第一指令以对所述容器进行第一种清洗模式的清洗或不清洗，否则发出第二指令对所述容器以进行第二种清洗模式的清洗，所述第二种清洗模式对特定物质的清洁强度大于所述第一种清洗模式对特定物质的清洁强度。其中，第一种清洗模式和第二种清洗模式可通过清洗子系统32进行，清洗子系统32的具体构成可参考前述实施例，本实施例中不作赘述。
其中，容器25可以是前述实施例中的比色池12或其他反应池，底液和待检测样本的成份包括但不限于以上实施例中所述，只要是采用依次先后加液的方式进行检测，均可通过中间状态(即加有一种、两种或三种及以上底液的状态)的第一本底电信号与预设本底电信号的大小比较来判断是否需要启用第二种清洗模式。
本实施例利用容器25仅盛放所述底液时进行检测而得到第一本底电信号，并以此作为判断是否需要采用专用清洗液进行清洗的触发条件，能够提高清洗的效率，保证了样本检测结果的准确性和仪器检测结果精密度的要求。
以上所述仅为本申请的实施方式，并非因此限制本申请的专利范围，凡是利用本申请说明书及附图内容所作的等效结构或等效流程变换，或直接或间接运用在其他相关的技术领域，均同理包括在本申请的专利保护范围内。

Claims (20)

  1. 一种样本分析装置，所述样本分析装置包括免疫分析子装置，其特征在于，所述装置还包括：
    控制器，与所述免疫分析子装置连接，用于控制所述免疫分析子装置在没有待检测样本时检测自身的第一本底电压值，根据所述第一本底电压值和预设本底电压阈值的大小比较来确定所述免疫分析子装置的清洗模式并发送对应的清洗指令；
    清洗子系统，与所述控制器连接，用于接收所述控制器发送的清洗指令，并响应所述清洗指令而对所述免疫分析子装置进行对应的清洗。
  2. 根据权利要求1所述的装置，其特征在于，所述清洗模式包括第一清洗模式和第二清洗模式，所述第一清洗模式是指采用第一清洗液对所述免疫分析子装置进行清洗，所述第二清洗模式是指采用第二清洗液对所述免疫分析子装置进行清洗。
  3. 根据权利要求2所述的装置，其特征在于，所述第一清洗液是常规清洗液，所述第二清洗液是专用清洗液。
  4. 根据权利要求1所述的装置，其特征在于，所述预设本底电压阈值M为90毫伏、95毫伏、100毫伏、105毫伏或110毫伏。
  5. 根据权利要求3所述的装置，其特征在于，所述专用清洗液为含溶血剂的清洗液。
  6. 根据权利要求2所述的装置，其特征在于，所述控制器具体用于控制所述免疫分析子装置在清洗后、没有待检测样本时检测自身的第一本底电压值，当所述第一本底电压值小于所述预设本底电压阈值时，所述控制器控制所述免疫分析子装置检测下一个待检测样本，并确定所述免疫分析子装置在检测完下一个待检测样本后的清洗模式为第一清洗模式，并发送对应的第一清洗指令；所述清洗子系统接收所述控制器发送的第一清洗指令，并响应所述第一清洗指令而在所述免疫分析子装置检测完下一个待检测样本后对所述免疫分析子装置进行对应的清洗；
    当所述第一本底电压大于或等于所述预设本底电压阈值时，所述控制器确定所述免疫分析子装置的清洗模式为第二清洗模式，并发送对应的第二清洗指令；所述清洗子系统接收所述控制器发送的第二清洗指令，并响应所述第二清 洗指令而对所述免疫分析子装置进行对应的清洗。
  7. 根据权利要求2所述的装置，其特征在于，所述装置还包括样本提供子装置、免疫试剂供给子装置、第一清洗液存储子装置以及第二清洗液存储子装置，
    所述样本提供子装置分别与所述控制器和所述免疫分析子装置连接，所述免疫试剂供给子装置分别与所述控制器和所述免疫分析子装置连接，所述第一清洗液存储子装置和第二清洗液存储子装置均与所述样本提供子装置连接；
    所述样本提供子装置在所述控制器的控制下，向所述免疫分析子装置提供待分析样本，或者将所述第一清洗液存储子装置中的第一清洗液提供给所述免疫分析子装置以进行清洗，或者将所述第二清洗液存储子装置中的第二清洗液提供给所述免疫分析子装置以进行清洗；
    所述免疫试剂供给子装置在所述控制器的控制下，向所述免疫分析子装置提供检测所述待分析样本所需的免疫试剂；
    所述第二清洗液存储子装置设置在所述样本提供子装置的行走路径上。
  8. 根据权利要求2所述的装置，其特征在于，所述装置还包括样本提供子装置、免疫试剂供给子装置、第二清洗液供给子装置、第一清洗液存储子装置以及第二清洗液存储子装置，
    所述样本提供子装置分别与所述控制器和所述免疫分析子装置连接，所述免疫试剂供给子装置分别与所述控制器和所述免疫分析子装置连接，所述第二清洗液供给子装置分别与所述控制器和所述免疫分析子装置连接，所述第一清洗液存储子装置与所述样本提供子装置连接，所述第二清洗液存储子装置与所述第二清洗液供给子装置连接；
    所述样本提供子装置在所述控制器的控制下，向所述免疫分析子装置提供待检测样本，或者将所述第一清洗液存储子装置中的第一清洗液提供给所述免疫分析子装置以进行清洗；
    所述第二清洗液供给子装置在所述控制器的控制下，将所述第二清洗液存储子装置中的第二清洗液提供给所述免疫分析子装置以进行清洗；
    所述免疫试剂供给子装置在所述控制器的控制下，向所述免疫分析子装置提供检测所述待检测样本所需的免疫试剂；
    所述第二清洗液存储子装置设置在所述样本分析装置的内部或者外部。
  9. 根据权利要求7或8任一项所述的装置，其特征在于，所述样本提供子装置包括采样针、驱动组件及管路。
  10. 一种样本分析装置的清洗方法，其特征在于，所述方法包括：
    控制免疫分析子装置在没有待检测样本时检测自身的第一本底电压值；
    根据所述第一本底电压值和预设本底电压阈值的大小比较来确定所述免疫分析子装置的清洗模式并发送对应的清洗指令；
    响应所述清洗指令而对所述免疫分析子装置进行对应的清洗。
  11. 根据权利要求10所述的方法，其特征在于，所述清洗模式包括第一清洗模式和第二清洗模式，所述第一清洗模式是指采用第一清洗液对所述免疫分析子装置进行清洗，所述第二清洗模式是指采用第二清洗液对所述免疫分析子装置进行清洗。
  12. 根据权利要求11所述的方法，其特征在于，所述第一清洗液是常规清洗液，所述第二清洗液是专用清洗液。
  13. 根据权利要求12所述的方法，其特征在于，所述预设本底电压阈值M为90毫伏、95毫伏、100毫伏、105毫伏或110毫伏。
  14. 根据权利要求12所述的方法，其特征在于，所述专用清洗液为含溶血剂的清洗液。
  15. 根据权利要求10所述的方法，其特征在于，所述控制所述免疫分析子装置在没有待检测样本时检测自身的第一本底电压值，包括：
    控制所述免疫分析子装置在清洗后、没有待检测样本时检测自身的第一本底电压值；
    所述根据所述第一本底电压值和预设本底电压阈值的大小比较来确定所述免疫分析子装置的清洗模式并发送对应的清洗指令，包括：
    当所述第一本底电压值小于所述预设本底电压阈值时，所述控制器控制所述免疫分析子装置检测下一个待检测样本，并确定所述免疫分析子装置在检测完下一个待检测样本后的清洗模式为第一清洗模式，并发送对应的第一清洗指令，当所述第一本底电压值大于或等于所述预设本底电压阈值时，所述控制器确定所述免疫分析子装置的清洗模式为第二清洗模式，并发送对应的第二清洗指令；
    所述响应所述清洗指令而对所述免疫分析子装置进行对应的清洗，包括：
    响应所述第一清洗指令而在所述免疫分析子装置检测完下一个待检测样本后对所述免疫分析子装置进行对应的清洗，或，响应所述第二清洗指令而对所述免疫分析子装置进行对应的清洗。
  16. 根据权利要求15所述的方法，其特征在于，所述响应所述第一清洗指令而在所述免疫分析子装置检测完下一个待检测样本后对所述免疫分析子装置进行对应的清洗，或，响应所述第二清洗指令而对所述免疫分析子装置进行对应的清洗，包括：
    响应所述第一清洗指令而在所述免疫分析子装置检测完下一个待检测样本后，控制所述样本提供子装置将所述第一清洗液存储子装置中的第一清洗液提供给所述免疫分析子装置以进行清洗，
    或者，响应所述第二清洗指令而控制所述样本提供子装置将所述第二清洗液存储子装置中的第二清洗液提供给所述免疫分析子装置以进行清洗。
  17. 根据权利要求15所述的方法，其特征在于，所述响应所述第一清洗指令而在所述免疫分析子装置检测完下一个待检测样本后对所述免疫分析子装置进行对应的清洗，或，响应所述第二清洗指令而对所述免疫分析子装置进行对应的清洗，包括：
    响应所述第一清洗指令而在所述免疫分析子装置检测完下一个待检测样本后，控制所述样本提供子装置将所述第一清洗液存储子装置中的第一清洗液提供给所述免疫分析子装置以进行清洗；
    或者，响应所述第二清洗指令而控制所述第二清洗液供给子装置将所述第二清洗液存储子装置中的第二清洗液提供给所述免疫分析子装置以进行清洗。
  18. 一种样本分析装置，其特征在于，包括：
    免疫分析子装置，所述免疫分析子装置包括比色池及分别设于所述比色池侧边的激光器和光电接收器，所述比色池在不作检测时用于装设浸泡液，在进行检测时用于排出所述浸泡液并装设底液和待检测样本，所述激光器用于朝向所述比色池发出激光以使得所述光电接收器获得光信号并转化为电信号，其中所述光电接收器在所述比色池排出所述浸泡液并仅装有所述底液时获得的电信号为第一本底电信号；
    控制器，用于获得所述第一本底电信号，并将所述第一本底电信号与预设本底电信号作比较并发出对应的清洗指令。
  19. 根据权利要求18所述的样本分析装置，其特征在于，所述样本分析装置还包括清洗子系统，所述清洗子系统用于响应所述清洗指令而对所述比色池进行对应的清洗，其中：
    当所述第一本底电信号小于所述预设本底电信号时，所述控制器发出第一清洗指令以使得所述清洗子系统采用第一清洗液对所述比色池进行清洗；
    当所述第一本底电信号大于或等于所述预设本底电信号时，所述控制器发出第二清洗指令以使得所述清洗子系统采用第二清洗液对所述比色池进行清洗，其中所述第二清洗液对特定物质的清洁强度大于所述第一清液液对所述特定物质的清洁强度。
  20. 一种样本分析装置，其特征在于，包括：
    容器，至少用于盛放底液和待检测样本；
    光电检测组件，用于在所述容器仅盛放所述底液时进行检测而得到第一本底电信号，在所述容器盛放所述底液和待检测样本时进行检测而得到样本检测电信号；
    控制器，用于在所述第一本底电信号小于预设本底电信号阈值时发出第一指令以对所述容器进行第一种清洗模式的清洗或不清洗，否则发出第二指令对所述容器以进行第二种清洗模式的清洗，所述第二种清洗模式对特定物质的清洁强度大于所述第一种清洗模式对特定物质的清洁强度。
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