WO2019078173A1 - Antimicrobial composition - Google Patents

Antimicrobial composition Download PDF

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Publication number
WO2019078173A1
WO2019078173A1 PCT/JP2018/038371 JP2018038371W WO2019078173A1 WO 2019078173 A1 WO2019078173 A1 WO 2019078173A1 JP 2018038371 W JP2018038371 W JP 2018038371W WO 2019078173 A1 WO2019078173 A1 WO 2019078173A1
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WO
WIPO (PCT)
Prior art keywords
acid
metal salts
metal salt
alkaline earth
alkali metal
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PCT/JP2018/038371
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French (fr)
Japanese (ja)
Inventor
彰宏 富士野
Original Assignee
株式会社日本抗菌総合研究所
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Application filed by 株式会社日本抗菌総合研究所 filed Critical 株式会社日本抗菌総合研究所
Priority to CN201880067226.XA priority Critical patent/CN111225564A/en
Priority to JP2019549277A priority patent/JP7298908B2/en
Publication of WO2019078173A1 publication Critical patent/WO2019078173A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
    • A01N37/04—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof polybasic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/06—Aluminium; Calcium; Magnesium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
    • A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
    • A23L3/3463—Organic compounds; Microorganisms; Enzymes
    • A23L3/3481—Organic compounds containing oxygen
    • A23L3/3508—Organic compounds containing oxygen containing carboxyl groups
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
    • A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
    • A23L3/3463—Organic compounds; Microorganisms; Enzymes
    • A23L3/3526—Organic compounds containing nitrogen
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
    • A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
    • A23L3/358—Inorganic compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/90—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in food processing or handling, e.g. food conservation

Definitions

  • the present invention relates to antimicrobial compositions.
  • Patent Document 1 discloses a water-degradable sheet obtained by impregnating a base paper sheet to which a water-soluble binder is added with a chemical solution, wherein the base paper sheet is formed by ply processing a plurality of base sheets and has a basis weight 30 to 150 gsm, the mixing ratio of softwood pulp to hardwood pulp is less than 1/1, and the content of the water-soluble binder is increased from the inner side in the thickness direction of the base paper sheet to the front and back sides,
  • the chemical solution includes a cross-linking agent that causes the water-soluble binder to cause a cross-linking reaction, and a sterilizing agent, and discloses a water-degradable sheet impregnated with 150 to 300% by weight of the chemical solution based on the weight of the base paper sheet. It is done.
  • Patent Document 2 discloses an antibacterial composition containing the following (A), (B), (C), (D) and (E).
  • (A) Chitosan and / or a salt thereof (B) 0.001 to 0.10% by mass of quaternary ammonium salt (C) alcohols (D) 0.01 to 1% by mass of a betaine amphoteric surfactant ( E) Water
  • the water-disintegratable sheet of Patent Document 1 is manufactured by impregnating a base paper sheet with a chemical solution.
  • the drug solution is generally prepared by dissolving benzalkonium chloride (quaternary ammonium salt) in water as in the antimicrobial composition of Patent Document 2.
  • the present invention provides an antimicrobial composition which can be easily dissolved in water to produce a drug solution with little or no precipitation, thereby suppressing transportation and storage costs.
  • the antibacterial composition of the present invention comprises 100 parts by mass of calcined calcium; Alkali metal salts of citric acid, alkaline earth metal salts of citric acid, alkali metal salts of gluconic acid, alkaline earth metal salts of gluconic acid, alkali metal salts of ascorbic acid, alkaline earth metal salts of ascorbic acid, malic acid Alkali metal salts of malic acid, alkaline earth metal salts of malic acid, alkaline metal salts of succinic acid, alkaline earth metal salts of succinic acid, alkaline metal salts of aspartic acid, alkaline earth metal salts of aspartic acid, alkaline metals of acetic acid And 100 to 600 parts by weight of at least one metal salt of an organic acid selected from the group consisting of salts, alkaline earth metal salts of acetic acid, alkali metal salts of ethylenediaminetetraacetic acid and alkaline earth metal salts of ethylenediaminet
  • the antimicrobial composition of the present invention can be easily dissolved in water with almost no control of the conditions for dissolution in water to produce a chemical solution in which almost no precipitation occurs. And the obtained chemical
  • medical solution has the outstanding antimicrobial property.
  • the antimicrobial composition of the present invention comprises calcined calcium and a metal salt of an organic acid.
  • the antimicrobial composition contains calcined calcium.
  • As baked calcium scallop shell baked calcium is preferable.
  • Calcined calcium is calcium source derived from animal origin whose main component is calcium carbonate before firing such as oyster shell, scallop shell, shellfish shell, egg shell, husk etc. at a temperature of 600 ° C. or higher, preferably 900 to 1200 ° C. It is obtained by baking or electric heating for about 60 minutes, and the main component is calcium oxide.
  • the antimicrobial composition contains a metal salt of an organic acid.
  • alkali metal salts of organic acids alkali metal salts of citric acid, alkaline earth metal salts of citric acid, alkali metal salts of gluconic acid, alkaline earth metal salts of gluconic acid, alkali metal salts of ascorbic acid, ascorbic acid Alkaline earth metal salts, alkali metal salts of malic acid, alkaline earth metal salts of malic acid, alkali metal salts of succinic acid, alkaline earth metal salts of succinic acid, alkali metal salts of aspartic acid, alkaline earth of aspartic acid Metal salts, alkali metal salts of acetic acid, alkaline earth metal salts of acetic acid, alkali metal salts of ethylenediaminetetraacetic acid, and metal salts of at least one organic acid selected from the group consisting of alkaline earth metal salts of ethylenediaminetetraacetic acid Contains
  • the metal salt of the organic acid may be used alone or in combination
  • the alkali metal salt of citric acid is not particularly limited, but sodium citrate and potassium citrate are preferable, and potassium citrate is more preferable.
  • the alkaline earth metal salt of citric acid is not particularly limited and, for example, magnesium citrate, calcium citrate, barium citrate and the like can be mentioned, and magnesium citrate and calcium citrate are preferable.
  • the alkali metal salt of gluconic acid is not particularly limited, but sodium gluconate and potassium gluconate are preferable, and sodium gluconate is more preferable.
  • the alkaline earth metal salt of gluconic acid is not particularly limited, and examples thereof include magnesium gluconate, calcium gluconate, barium gluconate and the like, with magnesium gluconate and calcium gluconate being preferred.
  • the alkali metal salt of ascorbic acid is not particularly limited, but sodium ascorbate and potassium ascorbate are preferable, and sodium ascorbate is more preferable.
  • the alkaline earth metal salt of ascorbic acid is not particularly limited, and examples thereof include magnesium ascorbate, calcium ascorbate, barium ascorbate and the like, with magnesium ascorbate and calcium ascorbate being preferred.
  • the alkali metal salt of malic acid is not particularly limited, but sodium malate and potassium malate are preferable, and sodium malate is more preferable.
  • the alkaline earth metal salt of malic acid is not particularly limited, and examples thereof include magnesium malate, calcium malate, barium malate and the like, and magnesium malate and calcium malate are preferable.
  • the alkali metal salt of succinic acid is not particularly limited, but sodium succinate and potassium succinate are preferable, and sodium succinate is more preferable.
  • the alkaline earth metal salt of succinic acid is not particularly limited, and examples thereof include magnesium succinate, calcium succinate, barium succinate and the like, and magnesium succinate and calcium succinate are preferable.
  • the alkali metal salt of aspartic acid is not particularly limited, but sodium aspartate and potassium aspartate are preferable, and sodium aspartate is more preferable.
  • the alkaline earth metal salt of aspartic acid is not particularly restricted but includes, for example, magnesium aspartate, calcium aspartate and barium aspartate, with magnesium aspartate and calcium aspartate being preferred.
  • the alkali metal salt of acetic acid is not particularly limited, but sodium acetate and potassium acetate are preferable, and sodium acetate is more preferable.
  • the alkaline earth metal salt of acetic acid is not particularly limited and, for example, magnesium acetate, calcium acetate, barium acetate and the like can be mentioned, and magnesium acetate and calcium acetate are preferable.
  • the alkali metal salt of ethylenediaminetetraacetic acid is not particularly limited, but sodium ethylenediaminetetraacetate and potassium ethylenediaminetetraacetate are preferable, sodium ethylenediaminetetraacetate is more preferable, and disodium ethylenediaminetetraacetate is particularly preferable.
  • the alkaline earth metal salt of ethylenediaminetetraacetic acid is not particularly limited, and examples thereof include magnesium ethylenediaminetetraacetate, calcium ethylenediaminetetraacetate, barium ethylenediaminetetraacetate and the like, with magnesium ethylenediaminetetraacetate and calcium ethylenediaminetetraacetate being preferred.
  • alkali metal salts of organic acids alkali metal salts of citric acid, alkaline earth metal salts of citric acid, alkali metal salts of gluconic acid, alkaline earth metal salts of gluconic acid, alkali metal salts of malic acid, malic acid Alkaline earth metal salts, alkali metal salts of ethylenediaminetetraacetic acid and alkaline earth metal salts of ethylenediaminetetraacetic acid are preferred, and alkali metal salts of citric acid, alkali metal salts of gluconic acid, alkaline earth metal salts of gluconic acid, apple Alkali metal salts of acids, alkaline earth metal salts of malic acid, alkali metal salts of ethylenediaminetetraacetic acid and alkaline earth metal salts of ethylenediaminetetraacetic acid are more preferable, alkali metal salts of malic acid, alkaline earth metals of malic acid Salts, alkali metal
  • At least one metal salt of gluconic acid selected from the group consisting of alkali metal salts of gluconic acid and alkaline earth metal salts of gluconic acid, with a metal salt of an organic acid; Alkali metal salt of succinic acid, alkaline earth metal salt of succinic acid, alkali metal salt of malic acid, alkaline earth metal salt of malic acid, alkali metal salt of citric acid and alkaline earth metal salt of citric acid And a metal salt of at least one organic acid selected from
  • the metal salt of an organic acid is an alkali metal salt of gluconic acid, It is more preferable to contain at least one alkali metal salt of an organic acid selected from the group consisting of alkali metal salts of succinic acid, alkali metal salts of malic acid and alkali metal salts of citric acid.
  • the metal salt of an organic acid is a sodium salt of gluconic acid, It is particularly preferable to contain sodium salt of at least one organic acid selected from the group consisting of sodium salt of succinic acid, sodium salt of malic acid and sodium salt of citric acid.
  • At least one metal salt of gluconic acid selected from the group consisting of alkali metal salts of gluconic acid and alkaline earth metal salts of gluconic acid, with a metal salt of an organic acid;
  • the metal salt of an organic acid is an alkali metal salt of gluconic acid, It is more preferable to contain an alkali metal salt of at least one organic acid selected from the group consisting of an alkali metal salt of succinic acid and an alkali metal salt of malic acid.
  • the metal salt of an organic acid is a sodium salt of gluconic acid, It is particularly preferable to contain at least one sodium salt of an organic acid selected from the group consisting of sodium salts of succinic acid and sodium salts of malic acid.
  • At least one metal salt of gluconic acid selected from the group consisting of alkali metal salts of gluconic acid and alkaline earth metal salts of gluconic acid, with a metal salt of an organic acid; It is preferable to contain at least one metal salt of an organic acid selected from the group consisting of an alkali metal salt of succinic acid and an alkaline earth metal salt of succinic acid.
  • the metal salt of the organic acid contains an alkali metal salt of gluconic acid and an alkali metal salt of succinic acid.
  • the metal salt of the organic acid comprises a sodium salt of gluconic acid and a sodium salt of succinic acid.
  • the content of the metal salt of gluconic acid in the metal salt of an organic acid is preferably 30 to 70% by mass, and 35 to 65% by mass 40 to 60% by mass is particularly preferable.
  • At least one metal salt of citric acid selected from the group consisting of alkali metal salts of citric acid and alkaline earth metal salts of citric acid; Alkali metal salts of succinic acid, alkaline earth metal salts of succinic acid, alkali metal salts of malic acid, alkaline earth metal salts of malic acid, alkali metal salts of aspartic acid, alkaline earth metal salts of aspartic acid, ethylene diamine It is preferable to contain at least one metal salt of an organic acid selected from the group consisting of an alkali metal salt of acetic acid and an alkaline earth metal salt of ethylenediaminetetraacetic acid.
  • a metal salt of an organic acid is an alkali metal salt of citric acid, An alkali metal salt of succinic acid, an alkali metal salt of malic acid, an alkali metal salt of aspartic acid, and an alkali metal salt of at least one organic acid selected from the group consisting of alkali metal salts of ethylenediaminetetraacetic acid Is more preferred.
  • Metal salts of organic acids are sodium salts of citric acid, It is particularly preferable to contain sodium salt of at least one organic acid selected from the group consisting of sodium salt of succinic acid, sodium salt of malic acid, sodium salt of aspartic acid and sodium salt of ethylenediaminetetraacetic acid.
  • At least one metal salt of citric acid selected from the group consisting of alkali metal salts of citric acid and alkaline earth metal salts of citric acid;
  • a metal salt of an organic acid is an alkali metal salt of citric acid, It is more preferable to contain an alkali metal salt of at least one organic acid selected from the group consisting of an alkali metal salt of succinic acid and an alkali metal salt of malic acid.
  • Metal salts of organic acids are sodium salts of citric acid, It is particularly preferable to contain at least one sodium salt of an organic acid selected from the group consisting of sodium salts of succinic acid and sodium salts of malic acid.
  • At least one metal salt of citric acid selected from the group consisting of alkali metal salts of citric acid and alkaline earth metal salts of citric acid; It is preferable to contain at least one metal salt of succinic acid selected from the group consisting of alkali metal salts of succinic acid and alkaline earth metal salts of succinic acid.
  • the metal salt of the organic acid contains an alkali metal salt of citric acid and an alkali metal salt of succinic acid.
  • the metal salt of the organic acid comprises a sodium salt of citric acid and a sodium salt of succinic acid.
  • the content of the metal salt of citric acid in the metal salt of an organic acid is preferably 30 to 70% by mass, and 35 to 65% by mass 40 to 60% by mass is particularly preferable.
  • the content of the metal salt of the organic acid in the antibacterial composition is 100 parts by mass or more, preferably 150 parts by mass or more, more preferably 200 parts by mass or more, and 220 parts by mass or more with respect to 100 parts by mass of calcined calcium. Is more preferable, and 250 parts by mass or more is particularly preferable.
  • the antibacterial composition has excellent antibacterial properties.
  • the content of the metal salt of the organic acid in the antibacterial composition is 600 parts by mass or less, preferably 500 parts by mass or less, more preferably 450 parts by mass or less, with respect to 100 parts by mass of calcined calcium. Is particularly preferred. When the content of the metal salt of the organic acid is 600 parts by mass or less, it can be dissolved in the antibacterial composition without precipitating the metal salt of the organic acid.
  • content of the metal salt of organic acid means total content of the metal salt of organic acid.
  • the antibacterial composition contains calcined calcium and a metal salt of an organic acid, the antibacterial composition can be easily dissolved in water without causing precipitation, while maintaining the antibacterial properties of calcined calcium. be able to. At this time, the antimicrobial composition can be easily dissolved by simply adding the antimicrobial composition to water without precisely controlling the dissolution conditions to produce a drug solution having antimicrobial properties. The obtained chemical solution hardly causes precipitation of the antibacterial composition, particularly calcined calcium, despite the temperature change.
  • the antimicrobial composition preferably contains a carbonate, a bicarbonate or a silicate.
  • the antibacterial properties of the antibacterial composition can be further improved, and the antibacterial composition can be provided with excellent detergency.
  • carbonates examples include sodium carbonate, potassium carbonate and the like, with sodium carbonate being preferred.
  • Examples of the hydrogen carbonate include sodium hydrogen carbonate and potassium hydrogen carbonate, and sodium hydrogen carbonate is preferable.
  • silicate for example, it is represented by M 2 O / nSiO 2 (wherein, M is sodium or potassium and n is the number of moles of SiO 2 ), and specifically, sodium orthosilicate, ortho sodium, ortho Potassium silicate, sodium sesquisilicate, potassium sesquisilicate, sodium metasilicate, potassium metasilicate, and No. 1 sodium silicate, No. 1 potassium silicate, No. 2 sodium silicate, No. 2 potassium silicate, No. 3 silicate, specified in JIS K 1408 Sodium, No. 3 potassium silicate and the like are mentioned, and sodium silicate is preferable.
  • the ratio of the mass of metal salt of organic acid to the mass of carbonate in the antibacterial composition is preferably 1 to 50, and more preferably 2 to 30, 3 to 20 is more preferable, and 3.5 to 10 is particularly preferable.
  • the antimicrobial property of the antimicrobial composition can be improved.
  • the antimicrobial composition can be provided with detergency.
  • the ratio of the mass of metal salt of organic acid to the mass of bicarbonate in the antibacterial composition is preferably 1 to 50, more preferably 2 to 30 Preferably, 3 to 20 is more preferable, and 3.5 to 10 is particularly preferable.
  • the ratio of the mass of metal salt of organic acid to the mass of bicarbonate is within the above range, the antimicrobial property of the antimicrobial composition is improved As well as imparting detergency to the antimicrobial composition.
  • the ratio of the mass of the metal salt of organic acid to the mass of silicate in the antibacterial composition is preferably 1 to 50, and more preferably 2 to 30, 3 to 20 are particularly preferred, and 3.5 to 10 are most preferred.
  • the antimicrobial property of the antimicrobial composition can be improved.
  • the antimicrobial composition can be provided with detergency.
  • the antimicrobial composition can be produced by mixing calcined calcium and a metal salt of an organic acid using a general mixing means.
  • the usage of the antimicrobial composition is described.
  • the antimicrobial composition can be dissolved in water to produce a drug solution having antimicrobial properties. It is not necessary to finely control the dissolution conditions for dissolving the antimicrobial composition in water, and the antimicrobial composition can be easily dissolved in water simply by adding the antimicrobial composition into water.
  • the content of the antimicrobial composition in the drug solution is preferably 0.01 to 10 parts by mass, more preferably 0.05 to 5 parts by mass, and still more preferably 0.07 to 3 parts by mass with respect to 100 parts by mass of water. And 0.08 to 2 parts by mass are particularly preferred.
  • the resulting drug solution causes almost no precipitation of the antibacterial composition, in particular, precipitation of calcined calcium. Therefore, it is not necessary to filter the precipitate when using the chemical solution, and the equipment and manufacturing process can be simplified.
  • the obtained chemical solution does not require the addition of a preservative, and can be stably stored while maintaining excellent antibacterial properties over a long period without deterioration.
  • a preservative what is generally used is mentioned, For example, p-oxybenzoic acid ester or its salt (parabens), phenoxyethanol, benzoic acid or its salt, sorbic acid or its salt, and glucone And the like.
  • an antibacterial sheet can be produced by impregnating cloth (non-woven fabric, woven fabric, knitted fabric, etc.) with a chemical solution.
  • the antimicrobial sheet can be used as, for example, a towel, a cleaning sheet, a toilet cleaner, and the like.
  • the antimicrobial composition does not contain a compound harmful to the human body, by immersing food products such as vegetables and fruits in a drug solution, it imparts antibacterial properties to food products and improves the storability. Can.
  • a drug solution can be used as a cleaning agent, and the body can be cleaned by wiping the body, such as hands and feet, with the drug solution.
  • the hair-washing agent shampoo
  • the hair rinse and the cleaning agent for washing the body contain water
  • the antibacterial composition is dissolved in water to dissolve the antibacterial composition in the hair-washing agent, the hair rinse and the cleaning agent.
  • the antimicrobial composition can impart an antimicrobial property to the water-based paint by being contained in the water-based paint.
  • the water-based paint contains water and a binder component dispersed in water. Since the antimicrobial composition can be dissolved in water with almost no precipitation, the antimicrobial composition can be uniformly contained in the aqueous coating, and uniformly contained in the resulting coating film. A coating film having antibacterial properties can be formed.
  • the antimicrobial composition can also be contained in cosmetics to impart antimicrobial properties to cosmetics.
  • the cosmetic may contain water, and examples thereof include a lotion.
  • the antimicrobial composition may be used by kneading it in a synthetic resin.
  • the antibacterial composition and the synthetic resin are supplied to an extruder, melt-kneaded, and extruded from the extruder to form a molded article of a desired shape (eg, sheet, food storage bag, daily necessities, vehicle interior material, architectural interior material) By doing this, a molded article having antibacterial properties can be obtained.
  • Examples 1 to 36 Calcined scallop calcium, sodium citrate, potassium citrate, sodium gluconate, potassium gluconate, sodium malate, sodium succinate, sodium aspartate, ethylenediaminetetraacetic acid disodium, sodium carbonate, potassium carbonate, sodium bicarbonate and silicic acid
  • the antimicrobial composition was prepared by mixing sodium in the predetermined amounts shown in Tables 1-4.
  • the antibacterial property and solubility of the obtained antibacterial composition were measured in the following manner, and the results are shown in Tables 1 to 4.
  • E. coli Esscherichia coli
  • 1000 parts by mass of water 1000 parts by mass of water.
  • E. coli Escherichia coli
  • test solution 100 ⁇ L of the test solution was inoculated into 200 mL of a test sample and cultured at 25 ° C.
  • a test solution prepared by diluting a 10-fold dilution series of the test sample with sterile saline 5 minutes and 30 minutes after inoculation was used as a test solution, and this test solution was inoculated on SCDLP agar medium and incubated at 35 ° C for 48 hours. Cultured. After culture, the formed colonies were counted to convert the viable cell count (cfu / mL).
  • the antimicrobial composition of the present invention can be easily dissolved in water to produce a drug solution.
  • a drug solution can be used to make an antimicrobial sheet or to impart antimicrobial properties to food products.
  • a chemical solution can also be used as a cleaning agent.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • General Health & Medical Sciences (AREA)
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Abstract

The present invention provides an antimicrobial composition which can be easily dissolved in water to produce a drug solution without bringing about almost any precipitation. The antimicrobial composition according to the present invention comprises: calcined calcium; and at least one type of organic acid metal salt selected from the group consisting of alkali metal salts of citric acid, alkali earth metal salts of citric acid, alkali metal salts of gluconic acid, alkali earth metal salts of gluconic acid, alkali metal salts of ascorbic acid, alkali earth metal salts of ascorbic acid, alkali metal salts of malic acid, alkali earth metal salts of malic acid, alkali metal salts of succinic acid, alkali earth metal salts of succinic acid, alkali metal salts of asparagine acid, alkali earth metal salts of asparagine acid, alkali metal salts of acetic acid, alkali earth metal salts of acetic acid, alkali metal salts of ethylenediaminetetraacetic acid, and alkali earth metal salts of ethylenediaminetetraacetic acid.

Description

抗菌性組成物Antibacterial composition
　本発明は、抗菌性組成物に関する。 The present invention relates to antimicrobial compositions.
　近年、衛生環境に対する意識の向上から、屋内外での食事の際にウエットシート又はおしぼりが用いられている。また、トイレの使用後に汚れた部分を簡易に除去するためのトイレクリーナが用いられている。 BACKGROUND ART In recent years, wet sheets or towels have been used when eating indoors and outdoors because of an increase in awareness of the hygiene environment. In addition, a toilet cleaner is used to easily remove the soiled portion after use of the toilet.
　特許文献１には、水溶性バインダーが添加された原紙シートに対して薬液を含浸させた水解性シートであって、前記原紙シートは、複数枚の原紙をプライ加工したものであり、かつ目付が３０～１５０ｇｓｍであり、広葉樹パルプに対する針葉樹パルプの配合比を１／１未満とし、当該原紙シートの厚み方向内側から表面及び裏面に向かうにつれて前記水溶性バインダーの含有量を増加させた状態とし、前記薬液には、前記水溶性バインダーに架橋反応を起こさせる架橋剤、及び除菌剤を含み、前記原紙シートの重量に対して１５０～３００重量％の前記薬液を含浸させている水解性シートが開示されている。 Patent Document 1 discloses a water-degradable sheet obtained by impregnating a base paper sheet to which a water-soluble binder is added with a chemical solution, wherein the base paper sheet is formed by ply processing a plurality of base sheets and has a basis weight 30 to 150 gsm, the mixing ratio of softwood pulp to hardwood pulp is less than 1/1, and the content of the water-soluble binder is increased from the inner side in the thickness direction of the base paper sheet to the front and back sides, The chemical solution includes a cross-linking agent that causes the water-soluble binder to cause a cross-linking reaction, and a sterilizing agent, and discloses a water-degradable sheet impregnated with 150 to 300% by weight of the chemical solution based on the weight of the base paper sheet. It is done.
　また、特許文献２には、下記（Ａ）、（Ｂ）、（Ｃ）、（Ｄ）及び（Ｅ）を含有する抗菌性組成物が開示されている。
（Ａ）キトサン及び／又はその塩
（Ｂ）０．００１～０．１０質量％の第四級アンモニウム塩
（Ｃ）アルコール類
（Ｄ）０．０１～１質量％のベタイン系両性界面活性剤
（Ｅ）水 Patent Document 2 discloses an antibacterial composition containing the following (A), (B), (C), (D) and (E).
(A) Chitosan and / or a salt thereof (B) 0.001 to 0.10% by mass of quaternary ammonium salt (C) alcohols (D) 0.01 to 1% by mass of a betaine amphoteric surfactant ( E) Water
特開２０１６－２２３０３０号公報JP, 2016-223030, A 特開２０１６－９４４１０号公報JP, 2016-94410, A
　特許文献１の水解性シートは、原紙シートに薬液を含浸させて製造されている。そして、薬液は、特許文献２の抗菌性組成物の如く、一般的に塩化ベンザルコニウム（第四級アンモニウム塩）を水に溶解させて作製されている。 The water-disintegratable sheet of Patent Document 1 is manufactured by impregnating a base paper sheet with a chemical solution. The drug solution is generally prepared by dissolving benzalkonium chloride (quaternary ammonium salt) in water as in the antimicrobial composition of Patent Document 2.
　しかしながら、塩化ベンザルコニウムを水に溶解させて沈澱を生じさせずに所定濃度の水溶液を作製するためには、製造条件をコントロールする必要があることから、通常、塩化ベンザルコニウムは、水に溶解させて水溶液とした上で供給されている。 However, it is usually necessary to control benzalkonium chloride in water, because it is necessary to control the preparation conditions in order to prepare benzalkonium chloride in water and prepare an aqueous solution of a predetermined concentration without causing precipitation. It is supplied after being dissolved to form an aqueous solution.
　そのため、塩化ベンザルコニウムの輸送時において、水溶液に含まれる塩化ベンザルコニウム自体の含有量が少量であるにもかかわらず、塩化ベンザルコニウム水溶液の体積及び重量が大きくなり、輸送コスト及び保管コストがかさむという問題点を有している。 Therefore, at the time of transportation of benzalkonium chloride, the volume and weight of the aqueous benzalkonium chloride solution become large despite the small content of benzalkonium chloride itself contained in the aqueous solution, and the transportation cost and the storage cost It has the problem that it takes a long time.
　本発明は、沈澱を殆ど生じさせることなく簡単に水に溶解させて薬液を製造することができ、輸送コスト及び保管コストを抑制することができる抗菌性組成物を提供する。 The present invention provides an antimicrobial composition which can be easily dissolved in water to produce a drug solution with little or no precipitation, thereby suppressing transportation and storage costs.
　本発明の抗菌性組成物は、焼成カルシウム１００質量部と、
　クエン酸のアルカリ金属塩、クエン酸のアルカリ土類金属塩、グルコン酸のアルカリ金属塩、グルコン酸のアルカリ土類金属塩、アスコルビン酸のアルカリ金属塩、アスコルビン酸のアルカリ土類金属塩、リンゴ酸のアルカリ金属塩、リンゴ酸のアルカリ土類金属塩、コハク酸のアルカリ金属塩、コハク酸のアルカリ土類金属塩、アスパラギン酸のアルカリ金属塩、アスパラギン酸のアルカリ土類金属塩、酢酸のアルカリ金属塩、酢酸のアルカリ土類金属塩、エチレンジアミン四酢酸のアルカリ金属塩及びエチレンジアミン四酢酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種の有機酸の金属塩１００～６００質量部とを含むことを特徴とする。 The antibacterial composition of the present invention comprises 100 parts by mass of calcined calcium;
Alkali metal salts of citric acid, alkaline earth metal salts of citric acid, alkali metal salts of gluconic acid, alkaline earth metal salts of gluconic acid, alkali metal salts of ascorbic acid, alkaline earth metal salts of ascorbic acid, malic acid Alkali metal salts of malic acid, alkaline earth metal salts of malic acid, alkaline metal salts of succinic acid, alkaline earth metal salts of succinic acid, alkaline metal salts of aspartic acid, alkaline earth metal salts of aspartic acid, alkaline metals of acetic acid And 100 to 600 parts by weight of at least one metal salt of an organic acid selected from the group consisting of salts, alkaline earth metal salts of acetic acid, alkali metal salts of ethylenediaminetetraacetic acid and alkaline earth metal salts of ethylenediaminetetraacetic acid It is characterized by
　本発明の抗菌性組成物は、水に溶解させる時の条件を殆ど制御することなく、水に容易に溶解させて、沈澱が殆ど生じていない薬液を製造することができる。そして、得られた薬液は、優れた抗菌性を有している。 The antimicrobial composition of the present invention can be easily dissolved in water with almost no control of the conditions for dissolution in water to produce a chemical solution in which almost no precipitation occurs. And the obtained chemical | medical solution has the outstanding antimicrobial property.
　本発明の抗菌性組成物は、焼成カルシウムと、有機酸の金属塩とを含む。 The antimicrobial composition of the present invention comprises calcined calcium and a metal salt of an organic acid.
（焼成カルシウム）
　抗菌性組成物は、焼成カルシウムを含有している。焼成カルシウムとしては、ほたて貝殻焼成カルシウムが好ましい。 (Calcinated calcium)
The antimicrobial composition contains calcined calcium. As baked calcium, scallop shell baked calcium is preferable.
　焼成カルシウムは、牡蠣殻、ホタテ貝殻、ホッキ貝殻、卵殻、珊瑚殻などの焼成前の主成分が炭酸カルシウムである動物性由来のカルシウム原料を６００℃以上、好ましくは９００～１２００℃の温度で１５～６０分程度焼成又は通電加熱して得られ、主成分を酸化カルシウムとするものである。 Calcined calcium is calcium source derived from animal origin whose main component is calcium carbonate before firing such as oyster shell, scallop shell, shellfish shell, egg shell, husk etc. at a temperature of 600 ° C. or higher, preferably 900 to 1200 ° C. It is obtained by baking or electric heating for about 60 minutes, and the main component is calcium oxide.
（有機酸の金属塩）
　抗菌性組成物は、有機酸の金属塩を含有している。 (Metal salt of organic acid)
The antimicrobial composition contains a metal salt of an organic acid.
　有機酸の金属塩としては、クエン酸のアルカリ金属塩、クエン酸のアルカリ土類金属塩、グルコン酸のアルカリ金属塩、グルコン酸のアルカリ土類金属塩、アスコルビン酸のアルカリ金属塩、アスコルビン酸のアルカリ土類金属塩、リンゴ酸のアルカリ金属塩、リンゴ酸のアルカリ土類金属塩、コハク酸のアルカリ金属塩、コハク酸のアルカリ土類金属塩、アスパラギン酸のアルカリ金属塩、アスパラギン酸のアルカリ土類金属塩、酢酸のアルカリ金属塩、酢酸のアルカリ土類金属塩、エチレンジアミン四酢酸のアルカリ金属塩及びエチレンジアミン四酢酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種の有機酸の金属塩を含有している。なお、有機酸の金属塩は、単独で用いられても二種以上が併用されてもよい。 As metal salts of organic acids, alkali metal salts of citric acid, alkaline earth metal salts of citric acid, alkali metal salts of gluconic acid, alkaline earth metal salts of gluconic acid, alkali metal salts of ascorbic acid, ascorbic acid Alkaline earth metal salts, alkali metal salts of malic acid, alkaline earth metal salts of malic acid, alkali metal salts of succinic acid, alkaline earth metal salts of succinic acid, alkali metal salts of aspartic acid, alkaline earth of aspartic acid Metal salts, alkali metal salts of acetic acid, alkaline earth metal salts of acetic acid, alkali metal salts of ethylenediaminetetraacetic acid, and metal salts of at least one organic acid selected from the group consisting of alkaline earth metal salts of ethylenediaminetetraacetic acid Contains The metal salt of the organic acid may be used alone or in combination of two or more.
　クエン酸のアルカリ金属塩としては、特に限定されないが、クエン酸ナトリウム、クエン酸カリウムが好ましく、クエン酸カリウムがより好ましい。 The alkali metal salt of citric acid is not particularly limited, but sodium citrate and potassium citrate are preferable, and potassium citrate is more preferable.
　クエン酸のアルカリ土類金属塩としては、特に限定されず、例えば、クエン酸マグネシウム、クエン酸カルシウム、クエン酸バリウムなどが挙げられ、クエン酸マグネシウム及びクエン酸カルシウムが好ましい。 The alkaline earth metal salt of citric acid is not particularly limited and, for example, magnesium citrate, calcium citrate, barium citrate and the like can be mentioned, and magnesium citrate and calcium citrate are preferable.
　グルコン酸のアルカリ金属塩としては、特に限定されないが、グルコン酸ナトリウム、グルコン酸カリウムが好ましく、グルコン酸ナトリウムがより好ましい。 The alkali metal salt of gluconic acid is not particularly limited, but sodium gluconate and potassium gluconate are preferable, and sodium gluconate is more preferable.
　グルコン酸のアルカリ土類金属塩としては、特に限定されず、例えば、グルコン酸マグネシウム、グルコン酸カルシウム、グルコン酸バリウムなどが挙げられ、グルコン酸マグネシウム及びグルコン酸カルシウムが好ましい。 The alkaline earth metal salt of gluconic acid is not particularly limited, and examples thereof include magnesium gluconate, calcium gluconate, barium gluconate and the like, with magnesium gluconate and calcium gluconate being preferred.
　アスコルビン酸のアルカリ金属塩としては、特に限定されないが、アスコルビン酸ナトリウム、アスコルビン酸カリウムが好ましく、アスコルビン酸ナトリウムがより好ましい。 The alkali metal salt of ascorbic acid is not particularly limited, but sodium ascorbate and potassium ascorbate are preferable, and sodium ascorbate is more preferable.
　アスコルビン酸のアルカリ土類金属塩としては、特に限定されず、例えば、アスコルビン酸マグネシウム、アスコルビン酸カルシウム、アスコルビン酸バリウムなどが挙げられ、アスコルビン酸マグネシウム及びアスコルビン酸カルシウムが好ましい。 The alkaline earth metal salt of ascorbic acid is not particularly limited, and examples thereof include magnesium ascorbate, calcium ascorbate, barium ascorbate and the like, with magnesium ascorbate and calcium ascorbate being preferred.
　リンゴ酸のアルカリ金属塩としては、特に限定されないが、リンゴ酸ナトリウム、リンゴ酸カリウムが好ましく、リンゴ酸ナトリウムがより好ましい。 The alkali metal salt of malic acid is not particularly limited, but sodium malate and potassium malate are preferable, and sodium malate is more preferable.
　リンゴ酸のアルカリ土類金属塩としては、特に限定されず、例えば、リンゴ酸マグネシウム、リンゴ酸カルシウム、リンゴ酸バリウムなどが挙げられ、リンゴ酸マグネシウム及びリンゴ酸カルシウムが好ましい。 The alkaline earth metal salt of malic acid is not particularly limited, and examples thereof include magnesium malate, calcium malate, barium malate and the like, and magnesium malate and calcium malate are preferable.
　コハク酸のアルカリ金属塩としては、特に限定されないが、コハク酸ナトリウム、コハク酸カリウムが好ましく、コハク酸ナトリウムがより好ましい。 The alkali metal salt of succinic acid is not particularly limited, but sodium succinate and potassium succinate are preferable, and sodium succinate is more preferable.
　コハク酸のアルカリ土類金属塩としては、特に限定されず、例えば、コハク酸マグネシウム、コハク酸カルシウム、コハク酸バリウムなどが挙げられ、コハク酸マグネシウム及びコハク酸カルシウムが好ましい。 The alkaline earth metal salt of succinic acid is not particularly limited, and examples thereof include magnesium succinate, calcium succinate, barium succinate and the like, and magnesium succinate and calcium succinate are preferable.
　アスパラギン酸のアルカリ金属塩としては、特に限定されないが、アスパラギン酸ナトリウム、アスパラギン酸カリウムが好ましく、アスパラギン酸ナトリウムがより好ましい。 The alkali metal salt of aspartic acid is not particularly limited, but sodium aspartate and potassium aspartate are preferable, and sodium aspartate is more preferable.
　アスパラギン酸のアルカリ土類金属塩としては、特に限定されず、例えば、アスパラギン酸マグネシウム、アスパラギン酸カルシウム、アスパラギン酸バリウムなどが挙げられ、アスパラギン酸マグネシウム及びアスパラギン酸カルシウムが好ましい。 The alkaline earth metal salt of aspartic acid is not particularly restricted but includes, for example, magnesium aspartate, calcium aspartate and barium aspartate, with magnesium aspartate and calcium aspartate being preferred.
　酢酸のアルカリ金属塩としては、特に限定されないが、酢酸ナトリウム、酢酸カリウムが好ましく、酢酸ナトリウムがより好ましい。 The alkali metal salt of acetic acid is not particularly limited, but sodium acetate and potassium acetate are preferable, and sodium acetate is more preferable.
　酢酸のアルカリ土類金属塩としては、特に限定されず、例えば、酢酸マグネシウム、酢酸カルシウム、酢酸バリウムなどが挙げられ、酢酸マグネシウム及び酢酸カルシウムが好ましい。 The alkaline earth metal salt of acetic acid is not particularly limited and, for example, magnesium acetate, calcium acetate, barium acetate and the like can be mentioned, and magnesium acetate and calcium acetate are preferable.
　エチレンジアミン四酢酸のアルカリ金属塩としては、特に限定されないが、エチレンジアミン四酢酸ナトリウム、エチレンジアミン四酢酸カリウムが好ましく、エチレンジアミン四酢酸ナトリウムがより好ましく、エチレンジアミン四酢酸二ナトリウムが特に好ましい。 The alkali metal salt of ethylenediaminetetraacetic acid is not particularly limited, but sodium ethylenediaminetetraacetate and potassium ethylenediaminetetraacetate are preferable, sodium ethylenediaminetetraacetate is more preferable, and disodium ethylenediaminetetraacetate is particularly preferable.
　エチレンジアミン四酢酸のアルカリ土類金属塩としては、特に限定されず、例えば、エチレンジアミン四酢酸マグネシウム、エチレンジアミン四酢酸カルシウム、エチレンジアミン四酢酸バリウムなどが挙げられ、エチレンジアミン四酢酸マグネシウム及びエチレンジアミン四酢酸カルシウムが好ましい。 The alkaline earth metal salt of ethylenediaminetetraacetic acid is not particularly limited, and examples thereof include magnesium ethylenediaminetetraacetate, calcium ethylenediaminetetraacetate, barium ethylenediaminetetraacetate and the like, with magnesium ethylenediaminetetraacetate and calcium ethylenediaminetetraacetate being preferred.
　有機酸の金属塩としては、クエン酸のアルカリ金属塩、クエン酸のアルカリ土類金属塩、グルコン酸のアルカリ金属塩、グルコン酸のアルカリ土類金属塩、リンゴ酸のアルカリ金属塩、リンゴ酸のアルカリ土類金属塩、エチレンジアミン四酢酸のアルカリ金属塩及びエチレンジアミン四酢酸のアルカリ土類金属塩が好ましく、クエン酸のアルカリ金属塩、グルコン酸のアルカリ金属塩、グルコン酸のアルカリ土類金属塩、リンゴ酸のアルカリ金属塩、リンゴ酸のアルカリ土類金属塩、エチレンジアミン四酢酸のアルカリ金属塩及びエチレンジアミン四酢酸のアルカリ土類金属塩がより好ましく、リンゴ酸のアルカリ金属塩、リンゴ酸のアルカリ土類金属塩、エチレンジアミン四酢酸のアルカリ金属塩及びエチレンジアミン四酢酸のアルカリ土類金属塩が特に好ましく、エチレンジアミン四酢酸のアルカリ金属塩及びエチレンジアミン四酢酸のアルカリ土類金属塩が最も好ましい。 As metal salts of organic acids, alkali metal salts of citric acid, alkaline earth metal salts of citric acid, alkali metal salts of gluconic acid, alkaline earth metal salts of gluconic acid, alkali metal salts of malic acid, malic acid Alkaline earth metal salts, alkali metal salts of ethylenediaminetetraacetic acid and alkaline earth metal salts of ethylenediaminetetraacetic acid are preferred, and alkali metal salts of citric acid, alkali metal salts of gluconic acid, alkaline earth metal salts of gluconic acid, apple Alkali metal salts of acids, alkaline earth metal salts of malic acid, alkali metal salts of ethylenediaminetetraacetic acid and alkaline earth metal salts of ethylenediaminetetraacetic acid are more preferable, alkali metal salts of malic acid, alkaline earth metals of malic acid Salts, alkali metal salts of ethylenediaminetetraacetic acid and alkalis of ethylenediaminetetraacetic acid Particularly preferred metalloid salts, alkaline earth metal salts of ethylenediamine tetraacetic alkali metal salts of acetic acid and ethylenediaminetetraacetic acid are most preferred.
　有機酸の金属塩が、グルコン酸のアルカリ金属塩及びグルコン酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種のグルコン酸の金属塩と、
　コハク酸のアルカリ金属塩、コハク酸のアルカリ土類金属塩、リンゴ酸のアルカリ金属塩、リンゴ酸のアルカリ土類金属塩、クエン酸のアルカリ金属塩及びクエン酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種の有機酸の金属塩とを含有していることが好ましい。 At least one metal salt of gluconic acid selected from the group consisting of alkali metal salts of gluconic acid and alkaline earth metal salts of gluconic acid, with a metal salt of an organic acid;
Alkali metal salt of succinic acid, alkaline earth metal salt of succinic acid, alkali metal salt of malic acid, alkaline earth metal salt of malic acid, alkali metal salt of citric acid and alkaline earth metal salt of citric acid And a metal salt of at least one organic acid selected from
　有機酸の金属塩が、グルコン酸のアルカリ金属塩と、
　コハク酸のアルカリ金属塩、リンゴ酸のアルカリ金属塩及びクエン酸のアルカリ金属塩からなる群から選ばれた少なくとも一種の有機酸のアルカリ金属塩とを含有していることがより好ましい。 The metal salt of an organic acid is an alkali metal salt of gluconic acid,
It is more preferable to contain at least one alkali metal salt of an organic acid selected from the group consisting of alkali metal salts of succinic acid, alkali metal salts of malic acid and alkali metal salts of citric acid.
　有機酸の金属塩が、グルコン酸のナトリウム塩と、
　コハク酸のナトリウム塩、リンゴ酸のナトリウム塩及びクエン酸のナトリウム塩からなる群から選ばれた少なくとも一種の有機酸のナトリウム塩とを含有していることが特に好ましい。 The metal salt of an organic acid is a sodium salt of gluconic acid,
It is particularly preferable to contain sodium salt of at least one organic acid selected from the group consisting of sodium salt of succinic acid, sodium salt of malic acid and sodium salt of citric acid.
　有機酸の金属塩が、グルコン酸のアルカリ金属塩及びグルコン酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種のグルコン酸の金属塩と、
　コハク酸のアルカリ金属塩、コハク酸のアルカリ土類金属塩、リンゴ酸のアルカリ金属塩及びリンゴ酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種の有機酸の金属塩とを含有していることが好ましい。 At least one metal salt of gluconic acid selected from the group consisting of alkali metal salts of gluconic acid and alkaline earth metal salts of gluconic acid, with a metal salt of an organic acid;
An alkali metal salt of succinic acid, an alkaline earth metal salt of succinic acid, an alkali metal salt of malic acid and a metal salt of at least one organic acid selected from the group consisting of alkaline earth metal salts of malic acid Is preferred.
　有機酸の金属塩が、グルコン酸のアルカリ金属塩と、
　コハク酸のアルカリ金属塩及びリンゴ酸のアルカリ金属塩からなる群から選ばれた少なくとも一種の有機酸のアルカリ金属塩とを含有していることがより好ましい。 The metal salt of an organic acid is an alkali metal salt of gluconic acid,
It is more preferable to contain an alkali metal salt of at least one organic acid selected from the group consisting of an alkali metal salt of succinic acid and an alkali metal salt of malic acid.
　有機酸の金属塩が、グルコン酸のナトリウム塩と、
　コハク酸のナトリウム塩及びリンゴ酸のナトリウム塩からなる群から選ばれた少なくとも一種の有機酸のナトリウム塩とを含有していることが特に好ましい。 The metal salt of an organic acid is a sodium salt of gluconic acid,
It is particularly preferable to contain at least one sodium salt of an organic acid selected from the group consisting of sodium salts of succinic acid and sodium salts of malic acid.
　有機酸の金属塩が、グルコン酸のアルカリ金属塩及びグルコン酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種のグルコン酸の金属塩と、
　コハク酸のアルカリ金属塩及びコハク酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種の有機酸の金属塩とを含有していることが好ましい。 At least one metal salt of gluconic acid selected from the group consisting of alkali metal salts of gluconic acid and alkaline earth metal salts of gluconic acid, with a metal salt of an organic acid;
It is preferable to contain at least one metal salt of an organic acid selected from the group consisting of an alkali metal salt of succinic acid and an alkaline earth metal salt of succinic acid.
　有機酸の金属塩が、グルコン酸のアルカリ金属塩と、コハク酸のアルカリ金属塩とを含有していることがより好ましい。 More preferably, the metal salt of the organic acid contains an alkali metal salt of gluconic acid and an alkali metal salt of succinic acid.
　有機酸の金属塩が、グルコン酸のナトリウム塩と、コハク酸のナトリウム塩とを含有していることが特に好ましい。 It is particularly preferred that the metal salt of the organic acid comprises a sodium salt of gluconic acid and a sodium salt of succinic acid.
　有機酸の金属塩が、グルコン酸の金属塩を含有している場合、有機酸の金属塩中、グルコン酸の金属塩の含有量は、３０～７０質量％が好ましく、３５～６５質量％がより好ましく、４０～６０質量％が特に好ましい。 When the metal salt of an organic acid contains a metal salt of gluconic acid, the content of the metal salt of gluconic acid in the metal salt of an organic acid is preferably 30 to 70% by mass, and 35 to 65% by mass 40 to 60% by mass is particularly preferable.
　有機酸の金属塩が、クエン酸のアルカリ金属塩及びクエン酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種のクエン酸の金属塩と、
　コハク酸のアルカリ金属塩、コハク酸のアルカリ土類金属塩、リンゴ酸のアルカリ金属塩、リンゴ酸のアルカリ土類金属塩、アスパラギン酸のアルカリ金属塩、アスパラギン酸のアルカリ土類金属塩、エチレンジアミン四酢酸のアルカリ金属塩及びエチレンジアミン四酢酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種の有機酸の金属塩とを含有していることが好ましい。 At least one metal salt of citric acid selected from the group consisting of alkali metal salts of citric acid and alkaline earth metal salts of citric acid;
Alkali metal salts of succinic acid, alkaline earth metal salts of succinic acid, alkali metal salts of malic acid, alkaline earth metal salts of malic acid, alkali metal salts of aspartic acid, alkaline earth metal salts of aspartic acid, ethylene diamine It is preferable to contain at least one metal salt of an organic acid selected from the group consisting of an alkali metal salt of acetic acid and an alkaline earth metal salt of ethylenediaminetetraacetic acid.
　有機酸の金属塩が、クエン酸のアルカリ金属塩と、
　コハク酸のアルカリ金属塩、リンゴ酸のアルカリ金属塩、アスパラギン酸のアルカリ金属塩及びエチレンジアミン四酢酸のアルカリ金属塩からなる群から選ばれた少なくとも一種の有機酸のアルカリ金属塩とを含有していることがより好ましい。 A metal salt of an organic acid is an alkali metal salt of citric acid,
An alkali metal salt of succinic acid, an alkali metal salt of malic acid, an alkali metal salt of aspartic acid, and an alkali metal salt of at least one organic acid selected from the group consisting of alkali metal salts of ethylenediaminetetraacetic acid Is more preferred.
　有機酸の金属塩が、クエン酸のナトリウム塩と、
　コハク酸のナトリウム塩、リンゴ酸のナトリウム塩、アスパラギン酸のナトリウム塩及びエチレンジアミン四酢酸のナトリウム塩からなる群から選ばれた少なくとも一種の有機酸のナトリウム塩とを含有していることが特に好ましい。 Metal salts of organic acids are sodium salts of citric acid,
It is particularly preferable to contain sodium salt of at least one organic acid selected from the group consisting of sodium salt of succinic acid, sodium salt of malic acid, sodium salt of aspartic acid and sodium salt of ethylenediaminetetraacetic acid.
　有機酸の金属塩が、クエン酸のアルカリ金属塩及びクエン酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種のクエン酸の金属塩と、
　コハク酸のアルカリ金属塩、コハク酸のアルカリ土類金属塩、リンゴ酸のアルカリ金属塩及びリンゴ酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種の有機酸の金属塩とを含有していることが好ましい。 At least one metal salt of citric acid selected from the group consisting of alkali metal salts of citric acid and alkaline earth metal salts of citric acid;
An alkali metal salt of succinic acid, an alkaline earth metal salt of succinic acid, an alkali metal salt of malic acid and a metal salt of at least one organic acid selected from the group consisting of alkaline earth metal salts of malic acid Is preferred.
　有機酸の金属塩が、クエン酸のアルカリ金属塩と、
　コハク酸のアルカリ金属塩及びリンゴ酸のアルカリ金属塩からなる群から選ばれた少なくとも一種の有機酸のアルカリ金属塩とを含有していることがより好ましい。 A metal salt of an organic acid is an alkali metal salt of citric acid,
It is more preferable to contain an alkali metal salt of at least one organic acid selected from the group consisting of an alkali metal salt of succinic acid and an alkali metal salt of malic acid.
　有機酸の金属塩が、クエン酸のナトリウム塩と、
　コハク酸のナトリウム塩及びリンゴ酸のナトリウム塩からなる群から選ばれた少なくとも一種の有機酸のナトリウム塩とを含有していることが特に好ましい。 Metal salts of organic acids are sodium salts of citric acid,
It is particularly preferable to contain at least one sodium salt of an organic acid selected from the group consisting of sodium salts of succinic acid and sodium salts of malic acid.
　有機酸の金属塩が、クエン酸のアルカリ金属塩及びクエン酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種のクエン酸の金属塩と、
　コハク酸のアルカリ金属塩及びコハク酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種のコハク酸の金属塩とを含有していることが好ましい。 At least one metal salt of citric acid selected from the group consisting of alkali metal salts of citric acid and alkaline earth metal salts of citric acid;
It is preferable to contain at least one metal salt of succinic acid selected from the group consisting of alkali metal salts of succinic acid and alkaline earth metal salts of succinic acid.
　有機酸の金属塩が、クエン酸のアルカリ金属塩と、コハク酸のアルカリ金属塩とを含有していることがより好ましい。 More preferably, the metal salt of the organic acid contains an alkali metal salt of citric acid and an alkali metal salt of succinic acid.
　有機酸の金属塩が、クエン酸のナトリウム塩と、コハク酸のナトリウム塩とを含有していることが特に好ましい。 It is particularly preferred that the metal salt of the organic acid comprises a sodium salt of citric acid and a sodium salt of succinic acid.
　有機酸の金属塩が、クエン酸の金属塩を含有している場合、有機酸の金属塩中、クエン酸の金属塩の含有量は、３０～７０質量％が好ましく、３５～６５質量％がより好ましく、４０～６０質量％が特に好ましい。 When the metal salt of an organic acid contains a metal salt of citric acid, the content of the metal salt of citric acid in the metal salt of an organic acid is preferably 30 to 70% by mass, and 35 to 65% by mass 40 to 60% by mass is particularly preferable.
　抗菌性組成物中における有機酸の金属塩の含有量は、焼成カルシウム１００質量部に対して１００質量部以上であり、１５０質量部以上が好ましく、２００質量部以上がより好ましく、２２０質量部以上がより好ましく、２５０質量部以上が特に好ましい。有機酸の金属塩の含有量が１００質量部以上であると、抗菌性組成物は優れた抗菌性を有する。 The content of the metal salt of the organic acid in the antibacterial composition is 100 parts by mass or more, preferably 150 parts by mass or more, more preferably 200 parts by mass or more, and 220 parts by mass or more with respect to 100 parts by mass of calcined calcium. Is more preferable, and 250 parts by mass or more is particularly preferable. When the content of the metal salt of the organic acid is 100 parts by mass or more, the antibacterial composition has excellent antibacterial properties.
　抗菌性組成物中における有機酸の金属塩の含有量は、焼成カルシウム１００質量部に対して６００質量部以下であり、５００質量部以下が好ましく、４５０質量部以下がより好ましく、３５０質量部以下が特に好ましい。有機酸の金属塩の含有量は、６００質量部以下であると、抗菌性組成物中に有機酸の金属塩を沈澱させることなく溶解させることができる。 The content of the metal salt of the organic acid in the antibacterial composition is 600 parts by mass or less, preferably 500 parts by mass or less, more preferably 450 parts by mass or less, with respect to 100 parts by mass of calcined calcium. Is particularly preferred. When the content of the metal salt of the organic acid is 600 parts by mass or less, it can be dissolved in the antibacterial composition without precipitating the metal salt of the organic acid.
　なお、有機酸の金属塩が複数種類含有されている場合は、「有機酸の金属塩の含有量」とは、有機酸の金属塩の総含有量をいう。 In addition, when multiple types of metal salt of organic acid are contained, "content of the metal salt of organic acid" means total content of the metal salt of organic acid.
　抗菌性組成物は、焼成カルシウムと有機酸の金属塩とを含有していることから、焼成カルシウムの抗菌性を維持しながら、抗菌性組成物を水中に沈澱を生じさせることなく簡単に溶解させることができる。この際、溶解条件を精密に制御することなく、抗菌性組成物を水に加えるだけで簡単に溶解させて抗菌性を有する薬液を作製することができる。得られた薬液は、温度変化にもかかわらず、抗菌性組成物、特に、焼成カルシウムの沈澱を生じさせることは殆どない。 Since the antibacterial composition contains calcined calcium and a metal salt of an organic acid, the antibacterial composition can be easily dissolved in water without causing precipitation, while maintaining the antibacterial properties of calcined calcium. be able to. At this time, the antimicrobial composition can be easily dissolved by simply adding the antimicrobial composition to water without precisely controlling the dissolution conditions to produce a drug solution having antimicrobial properties. The obtained chemical solution hardly causes precipitation of the antibacterial composition, particularly calcined calcium, despite the temperature change.
（炭酸塩、炭酸水素塩及び珪酸塩）
　抗菌性組成物は、炭酸塩、炭酸水素塩又は珪酸塩を含有していることが好ましい。抗菌性組成物の抗菌性をより向上させることができると共に、抗菌性組成物に優れた洗浄性を付与することができる。 (Carbonate, bicarbonate and silicate)
The antimicrobial composition preferably contains a carbonate, a bicarbonate or a silicate. The antibacterial properties of the antibacterial composition can be further improved, and the antibacterial composition can be provided with excellent detergency.
　炭酸塩としては、例えば、炭酸ナトリウム、炭酸カリウムなどが挙げられ、炭酸ナトリウムが好ましい。 Examples of carbonates include sodium carbonate, potassium carbonate and the like, with sodium carbonate being preferred.
　炭酸水素塩としては、例えば、炭酸水素ナトリウム、炭酸水素カリウムなどが挙げられ、炭酸水素ナトリウムが好ましい。 Examples of the hydrogen carbonate include sodium hydrogen carbonate and potassium hydrogen carbonate, and sodium hydrogen carbonate is preferable.
　珪酸塩としては、例えば、Ｍ2Ｏ／ｎＳｉＯ2（式中、Ｍはナトリウム又はカリウムであり、ｎはＳｉＯ2のモル数である。）で表され、具体的には、オルソ珪酸ナトリウム、オルソ珪酸カリウム、セスキ珪酸ナトリウム、セスキ珪酸カリウム、メタ珪酸ナトリウム、メタ珪酸カリウムや、ＪＩＳ　Ｋ１４０８に規定されている１号珪酸ナトリウム、１号珪酸カリウム、２号珪酸ナトリウム、２号珪酸カリウム、３号珪酸ナトリウム、３号珪酸カリウムなどが挙げられ、珪酸ナトリウムが好ましい。 As the silicate, for example, it is represented by M 2 O / nSiO 2 (wherein, M is sodium or potassium and n is the number of moles of SiO 2 ), and specifically, sodium orthosilicate, ortho sodium, ortho Potassium silicate, sodium sesquisilicate, potassium sesquisilicate, sodium metasilicate, potassium metasilicate, and No. 1 sodium silicate, No. 1 potassium silicate, No. 2 sodium silicate, No. 2 potassium silicate, No. 3 silicate, specified in JIS K 1408 Sodium, No. 3 potassium silicate and the like are mentioned, and sodium silicate is preferable.
　抗菌性組成物中における有機酸の金属塩の質量と炭酸塩の質量との比（有機酸の金属塩の質量／炭酸塩の質量）は、１～５０が好ましく、２～３０がより好ましく、３～２０がより好ましく、３．５～１０が特に好ましい。有機酸の金属塩の質量と炭酸塩の質量との比（有機酸の金属塩の質量／炭酸塩の質量）が上記範囲内であると、抗菌性組成物の抗菌性を向上させることができると共に、抗菌性組成物に洗浄性を付与することができる。 The ratio of the mass of metal salt of organic acid to the mass of carbonate in the antibacterial composition (mass of metal salt of organic acid / mass of carbonate) is preferably 1 to 50, and more preferably 2 to 30, 3 to 20 is more preferable, and 3.5 to 10 is particularly preferable. When the ratio of the mass of metal salt of organic acid to the mass of carbonate (mass of metal salt of organic acid / mass of carbonate) is within the above range, the antimicrobial property of the antimicrobial composition can be improved. In addition, the antimicrobial composition can be provided with detergency.
　抗菌性組成物中における有機酸の金属塩の質量と炭酸水素塩の質量との比（有機酸の金属塩の質量／炭酸水素塩の質量）は、１～５０が好ましく、２～３０がより好ましく、３～２０がより好ましく、３．５～１０が特に好ましい。有機酸の金属塩の質量と炭酸水素塩の質量との比（有機酸の金属塩の質量／炭酸水素塩の質量）が上記範囲内であると、抗菌性組成物の抗菌性を向上させることができると共に、抗菌性組成物に洗浄性を付与することができる。 The ratio of the mass of metal salt of organic acid to the mass of bicarbonate in the antibacterial composition (mass of metal salt of organic acid / mass of bicarbonate) is preferably 1 to 50, more preferably 2 to 30 Preferably, 3 to 20 is more preferable, and 3.5 to 10 is particularly preferable. When the ratio of the mass of metal salt of organic acid to the mass of bicarbonate (mass of metal salt of organic acid / mass of bicarbonate) is within the above range, the antimicrobial property of the antimicrobial composition is improved As well as imparting detergency to the antimicrobial composition.
　抗菌性組成物中における有機酸の金属塩の質量と珪酸塩の質量との比（有機酸の金属塩の質量／珪酸塩の質量）は、１～５０が好ましく、２～３０がより好ましく、３～２０が特に好ましく、３．５～１０が最も好ましい。有機酸の金属塩の質量と珪酸塩の質量との比（有機酸の金属塩の質量／珪酸塩の質量）が上記範囲内であると、抗菌性組成物の抗菌性を向上させることができると共に、抗菌性組成物に洗浄性を付与することができる。 The ratio of the mass of the metal salt of organic acid to the mass of silicate in the antibacterial composition (mass of metal salt of organic acid / mass of silicate) is preferably 1 to 50, and more preferably 2 to 30, 3 to 20 are particularly preferred, and 3.5 to 10 are most preferred. When the ratio of the mass of the metal salt of organic acid to the mass of silicate (mass of metal salt of organic acid / mass of silicate) is within the above range, the antimicrobial property of the antimicrobial composition can be improved. In addition, the antimicrobial composition can be provided with detergency.
（抗菌性組成物）
　抗菌性組成物は、焼成カルシウムと有機酸の金属塩とを汎用の混合手段を用いて混合することによって製造することができる。 (Antimicrobial composition)
The antimicrobial composition can be produced by mixing calcined calcium and a metal salt of an organic acid using a general mixing means.
　抗菌性組成物の使用要領について説明する。抗菌性組成物は、水に溶解させて抗菌性を有する薬液を製造することができる。抗菌性組成物を水中に溶解させるにあたって溶解条件を細かく制御する必要はなく、抗菌性組成物を水中に加えるだけで抗菌性組成物を水中に容易に溶解させることができる。 The usage of the antimicrobial composition is described. The antimicrobial composition can be dissolved in water to produce a drug solution having antimicrobial properties. It is not necessary to finely control the dissolution conditions for dissolving the antimicrobial composition in water, and the antimicrobial composition can be easily dissolved in water simply by adding the antimicrobial composition into water.
　薬液中における抗菌性組成物の含有量は、水１００質量部に対して０．０１～１０質量部が好ましく、０．０５～５質量部がより好ましく、０．０７～３質量部がより好ましく、０．０８～２質量部が特に好ましい。 The content of the antimicrobial composition in the drug solution is preferably 0.01 to 10 parts by mass, more preferably 0.05 to 5 parts by mass, and still more preferably 0.07 to 3 parts by mass with respect to 100 parts by mass of water. And 0.08 to 2 parts by mass are particularly preferred.
　得られた薬液は、抗菌性組成物の沈澱、特に、焼成カルシウムの沈澱を殆ど生じることがない。従って、薬液を用いるにあたって沈殿物のろ過を行う必要はなく、設備及び製造工程の簡略化を図ることができる。 The resulting drug solution causes almost no precipitation of the antibacterial composition, in particular, precipitation of calcined calcium. Therefore, it is not necessary to filter the precipitate when using the chemical solution, and the equipment and manufacturing process can be simplified.
　しかも、得られた薬液は、防腐剤の添加を必要とせず、変質することなく長期間に亘って優れた抗菌性を維持しながら安定的に保存することができる。なお、防腐剤としては、一般的に用いられているものが挙げられ、例えば、パラオキシ安息香酸エステル又はその塩類（パラベン類）、フェノキシエタノール、安息香酸又はその塩類、ソルビン酸又はその塩類、及び、グルコン酸クロルヘキシジンなどが挙げられる。 In addition, the obtained chemical solution does not require the addition of a preservative, and can be stably stored while maintaining excellent antibacterial properties over a long period without deterioration. In addition, as a preservative, what is generally used is mentioned, For example, p-oxybenzoic acid ester or its salt (parabens), phenoxyethanol, benzoic acid or its salt, sorbic acid or its salt, and glucone And the like.
　そして、薬液を布（不織布、織布、編布など）に含浸させることによって抗菌性シートを作製することができる。抗菌性シートは、例えば、おしぼり、清拭シート、トイレクリーナなどとして用いることができる。 And an antibacterial sheet can be produced by impregnating cloth (non-woven fabric, woven fabric, knitted fabric, etc.) with a chemical solution. The antimicrobial sheet can be used as, for example, a towel, a cleaning sheet, a toilet cleaner, and the like.
　また、抗菌性組成物は、人体に有害な化合物を含有していないことから、野菜や果物などの食料品を薬液に浸すことによって、食料品に抗菌性を付与し、保存性を向上させることができる。 In addition, since the antimicrobial composition does not contain a compound harmful to the human body, by immersing food products such as vegetables and fruits in a drug solution, it imparts antibacterial properties to food products and improves the storability. Can.
　更に、薬液を洗浄剤として用いることができ、薬液で手足などの身体を拭くことによって、身体を清潔にすることができる。 Furthermore, a drug solution can be used as a cleaning agent, and the body can be cleaned by wiping the body, such as hands and feet, with the drug solution.
　又、洗髪剤（シャンプー）、ヘアリンス及び身体を洗浄するための洗浄剤には水が含まれているので、水に抗菌性組成物を溶解させることによって、洗髪剤、ヘアリンス及び洗浄剤に抗菌性を付与することができ、洗髪剤、ヘアリンス及び洗浄剤を長期間に亘って安定的に保存することができる。 In addition, since the hair-washing agent (shampoo), the hair rinse and the cleaning agent for washing the body contain water, the antibacterial composition is dissolved in water to dissolve the antibacterial composition in the hair-washing agent, the hair rinse and the cleaning agent. Can be applied, and the hair-washing agent, the hair rinse and the cleaning agent can be stably stored over a long period of time.
　抗菌性組成物は水性塗料に含有させることによって、水性塗料に抗菌性を付与することができる。水性塗料は、水と、水に分散させたバインダー成分とを含有している。抗菌性組成物は、沈澱を殆ど生じさせることなく水に溶解させることができるので、水性塗料中に抗菌性組成物を均一に含有させることができ、得られる塗膜中に均一に含有させて抗菌性を有する塗膜を形成することができる。 The antimicrobial composition can impart an antimicrobial property to the water-based paint by being contained in the water-based paint. The water-based paint contains water and a binder component dispersed in water. Since the antimicrobial composition can be dissolved in water with almost no precipitation, the antimicrobial composition can be uniformly contained in the aqueous coating, and uniformly contained in the resulting coating film. A coating film having antibacterial properties can be formed.
　抗菌性組成物は、化粧品に含有させて化粧品に抗菌性を付与することもできる。化粧品としては、水を含有しておればよく、例えば、化粧水などが挙げられる。 The antimicrobial composition can also be contained in cosmetics to impart antimicrobial properties to cosmetics. The cosmetic may contain water, and examples thereof include a lotion.
　また、抗菌性組成物は、合成樹脂に練り込んで用いてもよい。抗菌性組成物及び合成樹脂を押出機に供給して溶融混練し、押出機から押出して所望形状の成形品（例えば、シート、食品保存袋、日用品、車両内装材、建築用内装材）を成形することによって、抗菌性を有する成形品を得ることができる。 In addition, the antimicrobial composition may be used by kneading it in a synthetic resin. The antibacterial composition and the synthetic resin are supplied to an extruder, melt-kneaded, and extruded from the extruder to form a molded article of a desired shape (eg, sheet, food storage bag, daily necessities, vehicle interior material, architectural interior material) By doing this, a molded article having antibacterial properties can be obtained.
　以下に、実施例を用いて本発明をより具体的に説明するが、本発明はこれらの実施例によって限定されない。 EXAMPLES Hereinafter, the present invention will be more specifically described using examples, but the present invention is not limited by these examples.
（実施例１～３６、比較例１～４）
　ほたて貝焼成カルシウム、クエン酸ナトリウム、クエン酸カリウム、グルコン酸ナトリウム、グルコン酸カリウム、リンゴ酸ナトリウム、コハク酸ナトリウム、アスパラギン酸ナトリウム、エチレンジアミン四酢酸二ナトリウム、炭酸ナトリウム、炭酸カリウム、炭酸水素ナトリウム及び珪酸ナトリウムを表１～４に示した所定量ずつ混合することによって抗菌性組成物を作製した。 (Examples 1 to 36, Comparative Examples 1 to 4)
Calcined scallop calcium, sodium citrate, potassium citrate, sodium gluconate, potassium gluconate, sodium malate, sodium succinate, sodium aspartate, ethylenediaminetetraacetic acid disodium, sodium carbonate, potassium carbonate, sodium bicarbonate and silicic acid The antimicrobial composition was prepared by mixing sodium in the predetermined amounts shown in Tables 1-4.
　得られた抗菌性組成物の抗菌性及び溶解性を下記の要領で測定し、その結果を表１～４に示した。 The antibacterial property and solubility of the obtained antibacterial composition were measured in the following manner, and the results are shown in Tables 1 to 4.
（抗菌性）
　抗菌性組成物１質量部を水１０００質量部に添加して溶解させて試験試料を作製した。大腸菌（Escherichia coli）を普通寒天培地に接種し、３５℃にて２４時間に亘って培養した。培養後、滅菌生理食塩水を用いて１０7／ｍＬに調整したものを試験菌液とした。 (Antibacterial)
One part by mass of the antibacterial composition was added to and dissolved in 1000 parts by mass of water to prepare a test sample. E. coli (Escherichia coli) was inoculated on a common agar medium and cultured at 35 ° C. for 24 hours. After culture, the solution adjusted to 10 7 / mL using sterile physiological saline was used as a test bacterial solution.
　試験試料２００ｍＬに試験菌液１００μＬ接種して２５℃で培養した。接種５分後及び３０分後に試験試料の１０倍希釈系列を、滅菌生理食塩水を用いて希釈作製したものを試験液とし、この試験液をＳＣＤＬＰ寒天培地に接種し、３５℃にて４８時間培養した。培養後、形成されたコロニーをカウントして生菌数（ｃｆｕ／ｍＬ）を換算した。 100 μL of the test solution was inoculated into 200 mL of a test sample and cultured at 25 ° C. A test solution prepared by diluting a 10-fold dilution series of the test sample with sterile saline 5 minutes and 30 minutes after inoculation was used as a test solution, and this test solution was inoculated on SCDLP agar medium and incubated at 35 ° C for 48 hours. Cultured. After culture, the formed colonies were counted to convert the viable cell count (cfu / mL).
　又、滅菌燐酸緩衝生理食塩水をコントロールとして上記と同様の要領で試験を行って生菌数を換算し、初菌数（ｃｆｕ／ｍＬ）とした。
　抗菌性（％）＝１００×（初菌数－生菌数）／（初菌数） Further, the test was carried out in the same manner as above using sterile phosphate buffered saline as a control, the viable cell count was converted, and the initial cell count (cfu / mL) was obtained.
Antibacterial activity (%) = 100 × (number of probiotics-number of viable bacteria) / (number of primary bacteria)
（溶解性）
　抗菌性組成物０．４質量部を水１００質量部に添加して溶解させて薬液を作製した。得られた薬液を２４時間静置した後、薬液の濁度（ＴＵＲ）を測定器（共立理化学研究所社製　商品名「ＷＡ－ＰＴ－４ＤＧ」）を用いて測定した。なお、薬液の濁度は、ホルマジン溶液を標準液として採用した。濁度が２０ホルマジン度以上である場合は「ＯＶＥＲ」と表記した。 (Solubility)
0.4 parts by mass of the antibacterial composition was added to 100 parts by mass of water and dissolved to prepare a drug solution. The resulting chemical solution was allowed to stand for 24 hours, and then the turbidity (TUR) of the chemical solution was measured using a measuring instrument (trade name "WA-PT-4DG" manufactured by Kyoritsu Chemical-Chemical Laboratories, Ltd.). In addition, the turbidity degree of the chemical | medical solution employ | adopted the formazine solution as a standard solution. When the degree of turbidity was 20 or more formazine degree, it was described as "OVER".
Figure JPOXMLDOC01-appb-T000001
Figure JPOXMLDOC01-appb-T000001
Figure JPOXMLDOC01-appb-T000002
Figure JPOXMLDOC01-appb-T000002
Figure JPOXMLDOC01-appb-T000003
Figure JPOXMLDOC01-appb-T000003
Figure JPOXMLDOC01-appb-T000004
Figure JPOXMLDOC01-appb-T000004
　（関連出願の相互参照）
　本出願は、２０１７年１０月１６日に出願された日本国特許出願第２０１７－２００１８１に基づく優先権を主張し、この出願の開示はこれらの全体を参照することにより本明細書に組み込まれる。 (Cross-reference to related applications)
This application claims the priority based on Japanese Patent Application No. 2017-201801 filed on Oct. 16, 2017, the disclosure of this application is incorporated herein by reference in its entirety.
　本発明の抗菌性組成物は、水に容易に溶解させて、薬液を製造することができる。薬液を用いて、抗菌性シートを作製し、又は、食料品に抗菌性を付与することができる。薬液を洗浄剤として用いることもできる。洗浄剤、水性塗料、化粧品及び合成樹脂などの対象物に抗菌性組成物を含有させることによって、対象物に抗菌性を付与することができる。 The antimicrobial composition of the present invention can be easily dissolved in water to produce a drug solution. A drug solution can be used to make an antimicrobial sheet or to impart antimicrobial properties to food products. A chemical solution can also be used as a cleaning agent. By incorporating the antimicrobial composition into objects such as detergents, aqueous paints, cosmetics and synthetic resins, it is possible to impart antimicrobial properties to the objects.

Claims (10)

  1. 　焼成カルシウム１００質量部と、
    　クエン酸のアルカリ金属塩、クエン酸のアルカリ土類金属塩、グルコン酸のアルカリ金属塩、グルコン酸のアルカリ土類金属塩、アスコルビン酸のアルカリ金属塩、アスコルビン酸のアルカリ土類金属塩、リンゴ酸のアルカリ金属塩、リンゴ酸のアルカリ土類金属塩、コハク酸のアルカリ金属塩、コハク酸のアルカリ土類金属塩、アスパラギン酸のアルカリ金属塩、アスパラギン酸のアルカリ土類金属塩、酢酸のアルカリ金属塩、酢酸のアルカリ土類金属塩、エチレンジアミン四酢酸のアルカリ金属塩及びエチレンジアミン四酢酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種の有機酸の金属塩１００～６００質量部とを含むことを特徴とする抗菌性組成物。     100 parts by mass of calcined calcium,
    Alkali metal salts of citric acid, alkaline earth metal salts of citric acid, alkali metal salts of gluconic acid, alkaline earth metal salts of gluconic acid, alkali metal salts of ascorbic acid, alkaline earth metal salts of ascorbic acid, malic acid Alkali metal salts of malic acid, alkaline earth metal salts of malic acid, alkaline metal salts of succinic acid, alkaline earth metal salts of succinic acid, alkaline metal salts of aspartic acid, alkaline earth metal salts of aspartic acid, alkaline metals of acetic acid And 100 to 600 parts by weight of at least one metal salt of an organic acid selected from the group consisting of salts, alkaline earth metal salts of acetic acid, alkali metal salts of ethylenediaminetetraacetic acid and alkaline earth metal salts of ethylenediaminetetraacetic acid An antimicrobial composition characterized in that.
  2. 　有機酸の金属塩が、クエン酸のアルカリ金属塩、クエン酸のアルカリ土類金属塩、グルコン酸のアルカリ金属塩、グルコン酸のアルカリ土類金属塩、リンゴ酸のアルカリ金属塩、リンゴ酸のアルカリ土類金属塩、エチレンジアミン四酢酸のアルカリ金属塩及びエチレンジアミン四酢酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種の有機酸の金属塩であることを特徴とする請求項１に記載の抗菌性組成物。 Metal salts of organic acids, alkali metal salts of citric acid, alkaline earth metal salts of citric acid, alkali metal salts of gluconic acid, alkaline earth metal salts of gluconic acid, alkali metal salts of malic acid, alkalis of malic acid Earth metal salt, an alkali metal salt of ethylenediaminetetraacetic acid, and a metal salt of at least one organic acid selected from the group consisting of alkaline earth metal salts of ethylenediaminetetraacetic acid. Antimicrobial composition.
  3. 　有機酸の金属塩が、グルコン酸のアルカリ金属塩及びグルコン酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種のグルコン酸の金属塩と、
    　コハク酸のアルカリ金属塩、コハク酸のアルカリ土類金属塩、リンゴ酸のアルカリ金属塩、リンゴ酸のアルカリ土類金属塩、クエン酸のアルカリ金属塩及びクエン酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種の有機酸の金属塩とを含有していることを特徴とする請求項１に記載の抗菌性組成物。     At least one metal salt of gluconic acid selected from the group consisting of alkali metal salts of gluconic acid and alkaline earth metal salts of gluconic acid, with a metal salt of an organic acid;
    Alkali metal salt of succinic acid, alkaline earth metal salt of succinic acid, alkali metal salt of malic acid, alkaline earth metal salt of malic acid, alkali metal salt of citric acid and alkaline earth metal salt of citric acid The antimicrobial composition according to claim 1, comprising at least one metal salt of an organic acid selected from the following.
  4. 　有機酸の金属塩が、グルコン酸の金属塩を３０～７０質量％含有していることを特徴とする請求項３に記載の抗菌性組成物。 The antimicrobial composition according to claim 3, wherein the metal salt of the organic acid contains 30 to 70% by mass of the metal salt of gluconic acid.
  5. 　有機酸の金属塩が、クエン酸のアルカリ金属塩及びクエン酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種のクエン酸の金属塩と、
    　コハク酸のアルカリ金属塩、コハク酸のアルカリ土類金属塩、リンゴ酸のアルカリ金属塩、リンゴ酸のアルカリ土類金属塩、アスパラギン酸のアルカリ金属塩、アスパラギン酸のアルカリ土類金属塩、エチレンジアミン四酢酸のアルカリ金属塩及びエチレンジアミン四酢酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種の有機酸の金属塩とを含有していることを特徴とする請求項１に記載の抗菌性組成物。     At least one metal salt of citric acid selected from the group consisting of alkali metal salts of citric acid and alkaline earth metal salts of citric acid;
    Alkali metal salts of succinic acid, alkaline earth metal salts of succinic acid, alkali metal salts of malic acid, alkaline earth metal salts of malic acid, alkali metal salts of aspartic acid, alkaline earth metal salts of aspartic acid, ethylene diamine The antimicrobial composition according to claim 1, characterized in that it comprises at least one metal salt of an organic acid selected from the group consisting of alkali metal salts of acetic acid and alkaline earth metal salts of ethylenediaminetetraacetic acid. object.
  6. 　有機酸の金属塩が、クエン酸の金属塩を３０～７０質量％含有していることを特徴とする請求項５に記載の抗菌性組成物。 The antimicrobial composition according to claim 5, wherein the metal salt of the organic acid contains 30 to 70% by mass of the metal salt of citric acid.
  7. 　有機酸の金属塩が、有機酸のナトリウム塩又は有機酸のカリウム塩であることを特徴とする請求項１又は請求項２に記載の抗菌性組成物。 The antimicrobial composition according to claim 1 or 2, wherein the metal salt of an organic acid is a sodium salt of an organic acid or a potassium salt of an organic acid.
  8. 　炭酸塩又は炭酸水素塩を更に含むことを特徴とする請求項１に記載の抗菌性組成物。 The antimicrobial composition of claim 1 further comprising a carbonate or bicarbonate.
  9. 　炭酸塩が、炭酸ナトリウム又は炭酸カリウムであることを特徴とする請求項８に記載の抗菌性組成物。 The antimicrobial composition according to claim 8, wherein the carbonate is sodium carbonate or potassium carbonate.
  10. 　炭酸水素塩が、炭酸水素ナトリウム又は炭酸水素カリウムであることを特徴とする請求項８に記載の抗菌性組成物。 The antimicrobial composition according to claim 8, wherein the bicarbonate is sodium bicarbonate or potassium bicarbonate.
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