JP6781006B2 - How to use antibacterial liquid cleaning agent and mixture for antibacterial cleaning agent - Google Patents
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Description
本発明は、家庭内のキッチン、冷蔵庫の中、トイレ、風呂等の抗菌性液体洗浄剤、及び抗菌性洗浄剤用混合物に関する。 The present invention relates to an antibacterial liquid cleaning agent for kitchens, refrigerators, toilets, baths, etc. in a home, and a mixture for an antibacterial cleaning agent.
従来から、界面活性剤を使用しない洗剤として、炭酸水素ナトリウム（重曹）、炭酸ナトリウム、セスキ炭酸ナトリウムが知られている。これらの炭酸塩系の洗剤は、界面活性剤を含む洗剤と比較して、使用目的によっては洗浄力が劣る場合があるものの、すすぎが容易で特有の洗浄効果も発揮できるという特徴を有していて、家庭内のキッチン洗浄、洗濯、油の汚れ落とし、鍋のコゲ落とし、入浴剤等への使用が知られている。 Conventionally, sodium hydrogen carbonate (baking soda), sodium carbonate, and sodium sesquicarbonate are known as detergents that do not use a surfactant. Compared to detergents containing surfactants, these carbonate-based detergents may have inferior detergency depending on the purpose of use, but have the characteristics of being easy to rinse and exhibiting a unique detergency effect. It is known to be used for cleaning kitchens in homes, washing clothes, removing oil stains, removing kogation from pots, and bathing agents.
排水として放出された場合にも環境負荷を低減させることができる、無機原料を主成分とする洗浄剤として、下記特許文献１には、乗り物の洗浄剤としてセスキ炭酸ソーダ等のアルカリ成分を主体とする洗浄剤に、超微粒子パウダーを添加すると洗浄力を高めることでき、塗装面に悪影響を与えずに、水垢をきれいに除去できることが開示されている。また、下記特許文献２には、セスキ炭酸ナトリウム等のアルカリビルダーに変性シリコーンを含有させた硬表面洗浄剤組成物が開示されている。 As a cleaning agent containing an inorganic raw material as a main component, which can reduce the environmental load even when released as wastewater, Patent Document 1 below describes mainly an alkaline component such as sodium sesquicarbonate as a vehicle cleaning agent. It is disclosed that the detergency can be enhanced by adding ultrafine powder to the cleaning agent to be used, and water stains can be removed cleanly without adversely affecting the coated surface. Further, Patent Document 2 below discloses a hard surface cleaning agent composition in which an alkaline builder such as sodium sesquicarbonate contains a modified silicone.
下記特許文献３には、炭酸ナトリウム、炭酸水素ナトリウム、セスキ炭酸ナトリウムからなる群より選択される１種以上と、炭酸カリウム、炭酸水素カリウムからなる群より選択される１種以上とを８０質量％以上含有する粉末の洗浄剤を水に溶解したときのイオン組成が、ナトリウムイオンがナトリウムイオンとカリウムイオンとのモル数合計に対して５〜４５モル％であり、かつ、炭酸イオンが炭酸イオンと重炭酸イオンとのモル数合計に対して２５〜８５モル％である洗浄剤が開示されている。 In Patent Document 3 below, 80% by mass of one or more selected from the group consisting of sodium carbonate, sodium hydrogen carbonate, and sodium sesquicarbonate and one or more selected from the group consisting of potassium carbonate and potassium hydrogen carbonate. The ion composition when the above-mentioned powder cleaning agent is dissolved in water is 5 to 45 mol% of sodium ions based on the total number of moles of sodium ions and potassium ions, and carbonate ions are carbonate ions. Disclosed are cleaning agents that are 25-85 mol% of the total number of moles with bicarbonate.
一方、下記特許文献４には、抗菌性を有する洗浄剤として過炭酸ナトリウム、炭酸水素ナトリウム等に銀、銅、亜鉛イオン等を担持させた無機物系担体を配合した洗浄剤が開示され、下記特許文献５には、抗菌性を有する洗浄剤として、抗菌性金属イオンを担持させた無機物系担体とカテキン類とを組み合わせて使用することが開示されている。 On the other hand, Patent Document 4 below discloses a cleaning agent in which an inorganic carrier in which silver, copper, zinc ions, etc. are supported on sodium percarbonate, sodium hydrogen carbonate, etc. is blended as a cleaning agent having antibacterial properties. Document 5 discloses that an inorganic carrier carrying an antibacterial metal ion and catechins are used in combination as a cleaning agent having antibacterial activity.
下記特許文献６の実施例には、主成分として界面活性剤を含む洗剤組成物中に、分子末端に２個のピリジン環又はキノリン環を有し、かつこれらの環の窒素原子が第４級アンモニウム基となっている４種の抗菌剤（該抗菌剤には、化学名：１，４-ビス（３，３’-(１-デシルピリジニウム）メチルオキシ)ブタンジブロマイド（以下、ＤＰＭＢＢと略記することがある）が含まれている）が試験液中でそれぞれ１質量％（１万質量ＰＰＭ）の濃度になるように配合され、かつ大腸菌（初期菌数１．３×１０６）を含む菌液添加されて、室温にて５，３０，６０分間保存すると、いずれも殺菌力を示すことが開示されている。下記特許文献７には、上記ＤＰＭＢＢが抗ウィルス化合物として水溶液又は水乳化体で使用できることが開示されている。 In the examples of Patent Document 6 below, a detergent composition containing a surfactant as a main component has two pyridine rings or quinoline rings at the molecular ends, and the nitrogen atom of these rings is quaternary. Four types of antibacterial agents that are ammonium groups (chemical names: 1,4-bis (3,3'-(1-decylpyridinium) methyloxy) butanjibromide (hereinafter abbreviated as DPMBB) it is present) are included) are blended to a concentration of 1 wt%, respectively in the test solution (10,000 weight PPM) to and including E. coli (initial bacteria number 1.3 × 10 6) It is disclosed that when the bacterial solution is added and stored at room temperature for 5, 30 and 60 minutes, all of them show bactericidal activity. Patent Document 7 below discloses that the DPMBB can be used as an antiviral compound in an aqueous solution or an emulsion.
上記特許文献１から特許文献３のいずれにも、除菌性、または抗菌性を有する洗浄剤は開示されていない。また、上記特許文献４、５には洗浄剤に金属イオン、金属イオンとカテキンをそれぞれ抗菌剤に用いることが開示されているが、いずれも抗菌剤の濃度は高い濃度である。上記特許文献６には界面活性剤を主成分とする洗剤中に上記ＤＰＭＢＢが高濃度（１万質量ｐｐｍ）に配合されていると抗菌性が発揮することが開示されている。また、上記特許文献７には上記ＤＰＭＢＢが水溶液又は水乳化体として抗ウィルス性を発揮できることが開示されている。従って、上記特許文献１〜特許文献７のいずれにおいても、無機原料である炭酸塩を主成分とし、極めて低濃度の抗菌剤を含有させることにより優れた抗菌性を発現する洗浄剤は開示されていない。 Neither Patent Document 1 to Patent Document 3 discloses a cleaning agent having sterilizing or antibacterial properties. Further, Patent Documents 4 and 5 disclose that metal ions, metal ions and catechins are used as antibacterial agents, respectively, but the concentration of the antibacterial agent is high in each of them. Patent Document 6 discloses that when the DPMBB is blended in a high concentration (10,000 mass ppm) in a detergent containing a surfactant as a main component, antibacterial properties are exhibited. Further, Patent Document 7 discloses that the DPMBB can exhibit antiviral properties as an aqueous solution or an emulsified product. Therefore, in any of the above Patent Documents 1 to 7, a cleaning agent that exhibits excellent antibacterial properties by containing a carbonate as an inorganic raw material as a main component and containing an extremely low concentration of an antibacterial agent is disclosed. Absent.
本発明は、環境に対する影響が少ない無機原料を主成分とし、洗浄後のすすぎが極めて容易で、かつ人体に対する安全性が高く、無刺激で、短時間で優れた抗菌効果をもたらす、抗菌性液体洗浄剤、及び抗菌性洗浄剤用混合物を提供することを目的とする。 The present invention is an antibacterial liquid containing an inorganic raw material having a small impact on the environment as a main component, which is extremely easy to rinse after cleaning, is highly safe for the human body, is non-irritating, and brings about an excellent antibacterial effect in a short time. It is an object of the present invention to provide a cleaning agent and a mixture for an antibacterial cleaning agent.
本発明者らは上記実情に鑑み鋭意検討した結果、炭酸水素ナトリウムと炭酸ナトリウムが含まれる、ｐＨが９．０〜１０．８の水溶液中に下記化学式で表される抗菌剤が微量含有されていると、優れた抗菌効果が得られることを見出し、本発明を完成させるに至った。すなわち、本発明は、以下の（１）〜（９）に記載の発明を要旨とする。 As a result of diligent studies in view of the above circumstances, the present inventors have found that a trace amount of an antibacterial agent represented by the following chemical formula is contained in an aqueous solution having a pH of 9.0 to 10.8 containing sodium hydrogen carbonate and sodium carbonate. It was found that an excellent antibacterial effect could be obtained, and the present invention was completed. That is, the gist of the present invention is the invention described in the following (1) to (9).
（１）炭酸水素ナトリウム、炭酸ナトリウム、及び下記式で表される抗菌剤を含む水溶液からなる抗菌性液体洗浄剤であって、
２５℃におけるｐＨが９．０〜１０．８であり、前記抗菌性液体洗浄剤中の該抗菌剤の含有量が５〜５００質量ｐｐｍである、ことを特徴とする抗菌性液体洗浄剤。
An antibacterial liquid cleaning agent characterized in that the pH at 25 ° C. is 9.0 to 10.8, and the content of the antibacterial agent in the antibacterial liquid cleaning agent is 5 to 500 parts by mass ppm .
（２）前記炭酸水素ナトリウムと炭酸ナトリウムの割合がモル比で１：１である、ことを特徴とする前記（１）に記載の抗菌性液体洗浄剤。
（３）前記炭酸水素ナトリウムと炭酸ナトリウムからなる成分の原料がトロナ鉱石である、ことを特徴とする前記（１）に記載の抗菌性液体洗浄剤。
（４）前記抗菌性液体洗浄剤中の炭酸水素ナトリウム及び炭酸ナトリウムの濃度が合わせて０．５〜５質量％である、ことを特徴とする前記（１）から（３）のいずれかに記載の抗菌性液体洗浄剤。
(2) The antibacterial liquid cleaning agent according to (1) above, wherein the ratio of sodium hydrogen carbonate to sodium carbonate is 1: 1 in molar ratio.
(3) The antibacterial liquid cleaning agent according to (1) above, wherein the raw material of the component composed of sodium hydrogen carbonate and sodium carbonate is trona ore.
(4) The above-mentioned (1) to (3), wherein the total concentration of sodium hydrogen carbonate and sodium carbonate in the antibacterial liquid cleaning agent is 0.5 to 5% by mass. Antibacterial liquid cleaning agent.
（５）炭酸水素ナトリウムと炭酸ナトリウムに、下記式で表される抗菌剤が配合された、抗菌性洗浄剤用混合物の使用方法であって、
炭酸水素ナトリウムと炭酸ナトリウムの割合は、前記炭酸水素ナトリウムと炭酸ナトリウムを合わせて水溶液中の濃度が１質量％になるように溶解させたときの２５℃におけるｐＨが９．０〜１０．８となる割合であり、
前記抗菌剤の含有量が０．０５〜５．０質量％である抗菌性洗浄剤用混合物を、
２５℃におけるｐＨが９．０〜１０．８、及び該抗菌剤の含有量が５〜５００質量ｐｐｍとなるように水に溶解して、抗菌性液体洗浄剤として使用する、
ことを特徴とする抗菌性洗浄剤用混合物の使用方法。
( 5 ) A method of using a mixture for an antibacterial cleaning agent in which an antibacterial agent represented by the following formula is blended with sodium hydrogen carbonate and sodium carbonate.
The ratio of sodium hydrogen carbonate and sodium carbonate is such that the pH at 25 ° C. is 9.0 to 10.8 when the sodium hydrogen carbonate and sodium carbonate are combined and dissolved so that the concentration in the aqueous solution becomes 1% by mass. Is the ratio
A mixture for an antibacterial cleaning agent having an antibacterial agent content of 0.05 to 5.0% by mass .
It is used as an antibacterial liquid cleaning agent by being dissolved in water so that the pH at 25 ° C. is 9.0 to 10.8 and the content of the antibacterial agent is 5 to 500 mass ppm.
A method of using a mixture for an antibacterial cleaning agent.
（６）前記炭酸水素ナトリウムと炭酸ナトリウムの割合がモル比で１：１である、ことを特徴とする前記（５）に記載の抗菌性洗浄剤用混合物の使用方法。
（７）前記炭酸水素ナトリウムと炭酸ナトリウムからなる成分の原料がトロナ鉱石である、ことを特徴とする前記（５）に記載の抗菌性洗浄剤用混合物の使用方法。
( 6 ) The method for using the antibacterial cleaning agent mixture according to ( 5 ) above, wherein the ratio of sodium hydrogen carbonate to sodium carbonate is 1: 1 in molar ratio.
( 7 ) The method for using the antibacterial cleaning agent mixture according to ( 5 ) above, wherein the raw material of the component composed of sodium hydrogen carbonate and sodium carbonate is trona ore.
本発明の抗菌性液体洗浄剤、及び抗菌性洗浄剤用混合物は、洗浄力を発揮する成分として環境に対する影響が少ない無機原料を使用するので、洗浄後のすすぎが極めて容易である。また、人体に対する安全性が高く、無刺激な抗菌剤を微量含有させることにより、短時間で優れた抗菌効果を発揮することができる。 Since the antibacterial liquid cleaning agent and the mixture for an antibacterial cleaning agent of the present invention use an inorganic raw material having a small impact on the environment as a component exhibiting detergency, rinsing after cleaning is extremely easy. In addition, it is highly safe for the human body, and by containing a small amount of a non-irritating antibacterial agent, an excellent antibacterial effect can be exhibited in a short time.
以下に、本発明の〔１〕抗菌性液体洗浄剤（第１の実施形態）、及び〔２〕抗菌性洗浄剤用混合物（第２の実施形態）について説明する。
〔１〕抗菌性液体洗浄剤（第１の実施形態）
本発明の抗菌性液体洗浄剤は、炭酸水素ナトリウム、炭酸ナトリウム、及び下記式で表される抗菌剤を含む抗菌性液体洗浄剤であって、
２５℃におけるｐＨが９．０〜１０．８であり、
該抗菌剤の含有量が４質量ｐｐｍ以上である、ことを特徴とする。
Hereinafter, [1] an antibacterial liquid cleaning agent (first embodiment) and [2] a mixture for an antibacterial cleaning agent (second embodiment) of the present invention will be described.
[1] Antibacterial liquid cleaning agent (first embodiment)
The antibacterial liquid cleaning agent of the present invention is an antibacterial liquid cleaning agent containing sodium hydrogen carbonate, sodium carbonate, and an antibacterial agent represented by the following formula.
The pH at 25 ° C. is 9.0 to 10.8.
The content of the antibacterial agent is 4 mass ppm or more.
（１）炭酸水素ナトリウムと炭酸ナトリウムについて
炭酸水素ナトリウム（重曹）、セスキ炭酸ナトリウム、及び炭酸ナトリウムは、いずれも洗浄力を有していることは知られており、それぞれｐＨが水溶液中で約８、１０、１１程度であり、ｐＨの相違等によって使い分けられているが、これらの中でもセスキ炭酸ナトリウムは、弱アルカリ性で取扱いが容易で、水への溶解性が高く、油汚れの落としやすさ等から洗浄剤として優れている。尚、セスキ炭酸ナトリウムは、炭酸水素ナトリウムと炭酸ナトリウムが１：１のモル比で構成される複塩（［ＨＣＯ３ −］・［ＣＯ３ ２−］・［Ｎａ＋］３）の通称である。
(1) Sodium hydrogen carbonate and sodium carbonate It is known that sodium hydrogen carbonate (baking soda), sodium sesquicarbonate, and sodium carbonate all have detergency, and each has a pH of about 8 in an aqueous solution. It is about 10, 11 and is used properly depending on the difference in pH, etc. Among these, sodium sesquicarbonate is weakly alkaline, easy to handle, highly soluble in water, easy to remove oil stains, etc. It is excellent as a cleaning agent. Incidentally, sodium sesquicarbonate is sodium sodium bicarbonate and carbonic acid is 1: double salt composed of a 1 molar ratio - is the common name for (· [CO 3 2-] · [Na +] 3 [HCO 3]) ..
本発明の抗菌性液体洗浄剤において、洗浄力を発揮する成分である、炭酸水素ナトリウムと炭酸ナトリウムの割合は、水溶液に溶解させた場合に２５℃におけるｐＨが９．０〜１０．８となる割合である。炭酸水素ナトリウムと炭酸ナトリウムが１：１のモル比の場合に２５℃におけるｐＨは１０程度であるので、該抗菌性液体洗浄剤の２５℃におけるｐＨが９．０〜１０．８の場合には、炭酸水素ナトリウムと炭酸ナトリウムのモル比１：１に近い成分になり、炭酸水素ナトリウムと炭酸ナトリウムの中間的な性質をあわせもつことになる。炭酸塩からなる洗浄剤の洗浄力は、油汚れ等を除去する際に、該炭酸塩のアルカリ金属イオン等による中和反応も関与していると考えられていることから、炭酸水素ナトリウムと炭酸ナトリウムの割合は、水溶液中でのｐＨを９．０以上の割合にする必要がある。尚、洗浄剤として、炭酸水素ナトリウムのみを使用すると、ｐＨが８程度の極めて弱いアルカリ性になるので十分な洗浄力は得られない。 In the antibacterial liquid cleaning agent of the present invention, the ratio of sodium hydrogen carbonate and sodium carbonate, which are components exhibiting detergency, has a pH of 9.0 to 10.8 at 25 ° C. when dissolved in an aqueous solution. Percentage. When the molar ratio of sodium hydrogen carbonate and sodium carbonate is 1: 1 the pH at 25 ° C. is about 10, so when the pH of the antibacterial liquid cleaning agent at 25 ° C. is 9.0 to 10.8. , Sodium hydrogen carbonate and sodium carbonate have a molar ratio close to 1: 1 and have intermediate properties between sodium hydrogen carbonate and sodium carbonate. Since it is considered that the detergency of a cleaning agent composed of carbonate is involved in the neutralization reaction of the carbonate by alkali metal ions or the like when removing oil stains or the like, sodium hydrogen carbonate and carbonic acid are considered to be involved. As for the ratio of sodium, the pH in the aqueous solution needs to be 9.0 or more. If only sodium hydrogen carbonate is used as the cleaning agent, the pH becomes extremely weak alkaline of about 8, and sufficient cleaning power cannot be obtained.
また、本発明の抗菌性液体洗浄剤を用いて洗浄する際に加熱すると、含有している炭酸水素ナトリウムは炭酸ガスを発生して、炭酸ナトリウムに変化するが、この際発生する炭酸ガス泡により鍋等のコゲ落とし効果が発揮される。炭酸ナトリウムのみを洗浄剤として使用すると加熱しても炭酸ガスは発生しないので、このような泡発生によるコゲの除去効果は得られない。また、汗の臭い、靴の蒸れた臭い等は酸性の臭い物質に起因するので、本発明の抗菌性液体洗浄剤は弱アルカリ性であることから、中和されることにより消臭効果も発揮する。該抗菌性液体洗浄剤中の洗浄効果を発揮する炭酸水素ナトリウム及び炭酸ナトリウムの濃度は特に制限されないが、洗浄効果と経済性を考慮すると、０．５〜５質量％が好ましく、実用上１．０質量％程度がより好ましい。 Further, when heated when cleaning with the antibacterial liquid cleaning agent of the present invention, the contained sodium hydrogen carbonate generates carbon dioxide gas and changes to sodium carbonate, but the carbon dioxide gas bubbles generated at this time generate carbon dioxide gas. The effect of removing kogation from pots is demonstrated. When only sodium carbonate is used as a cleaning agent, carbon dioxide gas is not generated even when heated, so that the effect of removing kogation due to such foam generation cannot be obtained. Further, since the odor of sweat, the odor of stuffy shoes, etc. are caused by acidic odor substances, the antibacterial liquid cleaning agent of the present invention is weakly alkaline, and therefore exerts a deodorizing effect by being neutralized. .. The concentrations of sodium hydrogen carbonate and sodium carbonate that exert a cleaning effect in the antibacterial liquid cleaning agent are not particularly limited, but 0.5 to 5% by mass is preferable in consideration of the cleaning effect and economy, and practically 1. About 0% by mass is more preferable.
本発明の抗菌性液体洗浄剤中で洗浄力を発揮する、炭酸水素ナトリウムと炭酸ナトリウムは、水溶液中の濃度が上記濃度になるように溶解させた際の２５℃におけるｐＨが９．０〜１０．８となる割合に混合すれば合成品を使用することもできるが、原料として天然のトロナ鉱石（trona）を使用することもできる。天然のトロナ鉱石の化学組成は、ＮａＨＣＯ３・Ｎａ２ＣＯ３・２Ｈ２Ｏで、セスキ炭酸ナトリウム二水和物とも呼ばれ、炭酸水素ナトリウムと炭酸ナトリウムとの等モルから構成される複塩で、分解温度が７０℃の固体（白色結晶粉末）である。トロナ鉱石は、大河や塩湖（ソーダ湖）の周辺に産出する。 Sodium hydrogen carbonate and sodium carbonate, which exert detergency in the antibacterial liquid cleaning agent of the present invention, have a pH of 9.0 to 10 at 25 ° C. when dissolved so that the concentration in the aqueous solution becomes the above concentration. A synthetic product can be used if it is mixed at a ratio of 8.8, but natural trona ore can also be used as a raw material. The chemical composition of natural trona ore in NaHCO 3 · Na 2 CO 3 · 2H 2 O, also known as sodium sesquicarbonate dihydrate, a double salt composed of equimolar with sodium bicarbonate and sodium carbonate , A solid (white crystal powder) having a decomposition temperature of 70 ° C. Trona ore is found around large rivers and salt lakes (Lake Soda).
本発明の抗菌性液体洗浄剤に含まれる洗浄力を発揮する、炭酸水素ナトリウムと炭酸ナトリウムには、本発明の効果を損なわない範囲で、他の塩基性物質としては、アルカリ金属化合物（例えば、水酸化ナトリウム等のアルカリ金属水酸化物；炭酸カリウム等のアルカリ金属炭酸塩；炭酸水素カリウム等のアルカリ金属炭酸水素塩；酢酸ナトリウム等のアルカリ金属カルボン酸塩）、アルカリ土類金属化合物（例えば、水酸化マグネシウム等のアルカリ土類金属水酸化物；炭酸マグネシウム等のアルカリ土類金属炭酸塩；酢酸マグネシウム等のアルカリ土類金属カルボン酸塩）等を配合することができる。 Sodium hydrogen carbonate and sodium carbonate, which exhibit the detergency contained in the antibacterial liquid cleaning agent of the present invention, include alkali metal compounds (for example, for example) as other basic substances as long as the effects of the present invention are not impaired. Alkali metal hydroxides such as sodium hydroxide; alkali metal carbonates such as potassium carbonate; alkali metal hydrogen carbonates such as potassium hydrogen carbonate; alkali metal carboxylates such as sodium acetate), alkaline earth metal compounds (eg, Alkali earth metal hydroxides such as magnesium hydroxide; alkaline earth metal carbonates such as magnesium carbonate; alkaline earth metal carboxylates such as magnesium acetate) and the like can be blended.
（２）抗菌剤について
本発明の抗菌性液体洗浄剤に使用する抗菌剤としては、優れた抗菌効果を有していて、微量で、かつ比較的短時間で効果を発揮できること、人体に対する安全性が高く、無刺激なことなどが必要とされる。尚、本明細書において、抗菌剤の意味は、殺菌剤と厳密には異なる意味合いもあるがほぼ同義語として扱っている。
(2) Antibacterial agent The antibacterial agent used in the antibacterial liquid cleaning agent of the present invention has an excellent antibacterial effect, can exert the effect in a small amount and in a relatively short time, and is safe for the human body. Is high and non-irritating is required. In addition, in this specification, the meaning of an antibacterial agent has a meaning different from that of a bactericidal agent, but is treated as a synonym.
分子末端に２個のピリジン環又はキノリン環を有し、かつこれらの環の窒素原子が第４級アンモニウム基となっている化合物の中には、抗菌剤、抗ウィルス性としての機能を有することは知られているが（特許文献６，７参照）、これらの中でも下記化学式で示される化学名：１，４-ビス（３，３’-(１-デシルピリジニウム）メチルオキシ)ブタンジブロマイド（ＤＰＭＢＢ）は、本発明の抗菌性液体洗浄剤に含有されると、極めて微量でも、抗菌効果の評価に広く使用されている大腸菌、黄色ブドウ球菌に対し優れた抗菌性を示すことが確認された。上記ＤＰＭＢＢは、融点が７７〜７９℃で、白色ないし淡褐色の固体で、水溶性に優れている。 Some compounds having two pyridine rings or quinoline rings at the molecular ends and the nitrogen atom of these rings being a quaternary ammonium group have antibacterial and antiviral functions. Is known (see Patent Documents 6 and 7), but among these, the chemical name represented by the following chemical formula: 1,4-bis (3,3'-(1-decylpyridinium) methyloxy) butanji bromide ( It was confirmed that DPMBB) exhibits excellent antibacterial properties against Escherichia coli and Yellow Drosophila, which are widely used for evaluation of antibacterial effects, even in extremely small amounts, when contained in the antibacterial liquid cleaning agent of the present invention. .. The DPMBB has a melting point of 77 to 79 ° C., is a white to light brown solid, and has excellent water solubility.
本発明の抗菌性液体洗浄剤中の該抗菌剤の含有量は、４質量ｐｐｍ以上、好ましくは５質量ｐｐｍ以上で優れた抗菌効果を発揮する。一方、該抗菌剤の含有量の上限は抗菌効果からは特に限定されるものではないが、経済性等を考慮すると５００質量ｐｐｍ以下が好ましく、２００質量ｐｐｍ以下がより好ましく、１００質量ｐｐｍ以下が更に好ましい。該抗菌剤によるこのような抗菌効果は、洗浄力を発揮する成分として、炭酸水素ナトリウムと炭酸ナトリウムが溶解している水溶液の２５℃におけるｐＨが９．０〜１０．８である場合に得られる特有の効果である。尚、該抗菌剤は、洗浄剤としてアルカリ金属塩類を使用する場合に、微量含有されていても常に優れた抗菌力を発揮できるとは限らない。例えば、炭酸水素ナトリウム濃度が１質量％の水溶液に、該抗菌剤が１０質量ｐｐｍの濃度になるように溶解されていても、大腸菌と黄色ブドウ球菌に対する優れた抗菌性は得られないことは確認されている。また、該抗菌剤は特許文献７において、水溶液又は水乳化体として抗ウィルス性を有すること、及び長期間使用しても耐性菌が発現しないことが確認されている。 When the content of the antibacterial agent in the antibacterial liquid cleaning agent of the present invention is 4 mass ppm or more, preferably 5 mass ppm or more, an excellent antibacterial effect is exhibited. On the other hand, the upper limit of the content of the antibacterial agent is not particularly limited from the antibacterial effect, but is preferably 500 mass ppm or less, more preferably 200 mass ppm or less, and 100 mass ppm or less in consideration of economic efficiency and the like. More preferred. Such an antibacterial effect of the antibacterial agent can be obtained when the pH of an aqueous solution in which sodium hydrogen carbonate and sodium carbonate are dissolved as a component exhibiting detergency is 9.0 to 10.8 at 25 ° C. This is a unique effect. When an alkali metal salt is used as a cleaning agent, the antibacterial agent may not always exhibit excellent antibacterial activity even if it is contained in a trace amount. For example, it has been confirmed that even if the antibacterial agent is dissolved in an aqueous solution having a sodium hydrogen carbonate concentration of 1% by mass so as to have a concentration of 10% by mass, excellent antibacterial properties against Escherichia coli and Staphylococcus aureus cannot be obtained. Has been done. Further, it has been confirmed in Patent Document 7 that the antibacterial agent has antiviral properties as an aqueous solution or an emulsified product, and that resistant bacteria do not develop even after long-term use.
（３）抗菌性液体洗浄剤の製造方法
本発明の抗菌性液体洗浄剤の成分である、炭酸水素ナトリウム、炭酸ナトリウム、及び前記除菌剤はいずれも水への溶解性に優れているので、水溶液に溶解することにより抗菌性液体洗浄剤が容易に得られる。本発明の抗菌性液体洗浄剤は、常温では比較的安定であるが、保存時の温度が７０℃を超えると、炭酸水素ナトリウムが分解して炭酸ガスが発生するおそれがあるので、常温に近い温度で保存することが望ましい。
(3) Method for Producing Antibacterial Liquid Cleaning Agent Sodium hydrogen carbonate, sodium carbonate, and the disinfectant, which are components of the antibacterial liquid cleaning agent of the present invention, are all excellent in solubility in water. An antibacterial liquid cleaning agent can be easily obtained by dissolving it in an aqueous solution. The antibacterial liquid cleaning agent of the present invention is relatively stable at room temperature, but if the storage temperature exceeds 70 ° C., sodium hydrogen carbonate may be decomposed to generate carbon dioxide gas, which is close to room temperature. It is desirable to store at temperature.
（４）その他
本発明の抗菌性液体洗浄剤は、冷蔵庫の内外、食器棚、電子レンジ等の調理器具、浴室、窓ガラス等の掃除、赤ちゃんのおもちゃ、ペット用品等の汚れ落としに有効である。
本発明の抗菌性液体洗浄剤は、汚れ落としをする際に直接スプレーした後にふき取るかもしくは洗い流しするか、又は柔らかい布かティッシュなどに含ませてふきとることが好ましい。
(4) Others The antibacterial liquid cleaning agent of the present invention is effective for cleaning the inside and outside of refrigerators, cupboards, cooking utensils such as microwave ovens, bathrooms, windowpanes, etc., and cleaning baby toys, pet supplies, etc. ..
When removing stains, the antibacterial liquid cleaning agent of the present invention is preferably sprayed directly and then wiped off or washed away, or soaked in a soft cloth or tissue to wipe off.
〔２〕抗菌性洗浄剤用混合物（第２の実施形態）
本発明の抗菌性洗浄剤用混合物は、炭酸水素ナトリウムと炭酸ナトリウムに、下記式で表される抗菌剤が配合された、抗菌性洗浄剤用混合物であって、炭酸水素ナトリウムと炭酸ナトリウムの割合は、水溶液中の濃度が１質量％になるように溶解させたときの２５℃におけるｐＨが９．０〜１０．８となる割合であり、該混合物中の前記抗菌剤の含有量が０．０４質量％以上である、ことを特徴とする。
[2] Mixture for antibacterial cleaning agent (second embodiment)
The mixture for antibacterial cleaning agent of the present invention is a mixture for antibacterial cleaning agent in which an antibacterial agent represented by the following formula is mixed with sodium hydrogen carbonate and sodium carbonate, and the ratio of sodium hydrogen carbonate and sodium carbonate. Is the ratio at which the pH at 25 ° C. is 9.0 to 10.8 when dissolved so that the concentration in the aqueous solution is 1% by mass, and the content of the antibacterial agent in the mixture is 0. It is characterized in that it is 04 mass% or more.
（１）炭酸水素ナトリウムと炭酸ナトリウムについて
本発明の抗菌性洗浄剤用混合物は、第１の実施形態に記載した抗菌性液体洗浄剤の原料に相当するので、炭酸水素ナトリウムと炭酸ナトリウムについては第１の実施形態に記載した通りである。該抗菌性洗浄剤用混合物中の洗浄効果を発揮する炭酸水素ナトリウムと炭酸ナトリウムの割合は、炭酸水素ナトリウムと炭酸ナトリウムを水溶液中の濃度が１質量％になるように溶解させたときの２５℃におけるｐＨが９．０〜１０．８となる割合である。
(1) Sodium hydrogen carbonate and sodium carbonate Since the mixture for antibacterial cleaning agent of the present invention corresponds to the raw material of the antibacterial liquid cleaning agent described in the first embodiment, sodium hydrogen carbonate and sodium carbonate are the first. As described in the first embodiment. The proportion of sodium bicarbonate and sodium carbonate which exhibits cleaning effect of antibacterial detergent for mixture, 25 ° C. when the concentration in the aqueous solution of sodium bicarbonate and sodium carbonate were dissolved at 1 wt% The pH is 9.0 to 10.8.
本発明の抗菌性液体洗浄剤中で洗浄力を発揮する、炭酸水素ナトリウムと炭酸ナトリウムは、水溶液で１質量％の濃度になるように溶解させたときの２５℃におけるｐＨが９．０〜１０．８となる割合に混合することにより合成品として得ることもできるが、前記の通り、天然のトロナ鉱石（trona）を使用することもできる。本発明の抗菌性洗浄剤用混合物で洗浄効果を発揮する、炭酸水素ナトリウムと炭酸ナトリウムには、本発明の効果を損なわない範囲で、他の塩基性物質としては、アルカリ金属化合物（例えば、水酸化ナトリウム等のアルカリ金属水酸化物；炭酸カリウム等のアルカリ金属炭酸塩；炭酸水素カリウム等のアルカリ金属炭酸水素塩；酢酸ナトリウム等のアルカリ金属カルボン酸塩）、アルカリ土類金属化合物（例えば、水酸化マグネシウム等のアルカリ土類金属水酸化物；炭酸マグネシウム等のアルカリ土類金属炭酸塩；酢酸マグネシウム等のアルカリ土類金属カルボン酸塩）等を配合することができる。 Sodium hydrogen carbonate and sodium carbonate, which exert detergency in the antibacterial liquid cleaning agent of the present invention, have a pH of 9.0 to 10 at 25 ° C. when dissolved in an aqueous solution to a concentration of 1% by mass. It can be obtained as a synthetic product by mixing in a ratio of .8, but as described above, natural trona ore (trona) can also be used. Sodium hydrogen carbonate and sodium carbonate, which exert a cleaning effect in the antibacterial cleaning agent mixture of the present invention, include alkali metal compounds (for example, water) as other basic substances as long as the effects of the present invention are not impaired. Alkali metal hydroxides such as sodium oxide; alkali metal carbonates such as potassium carbonate; alkali metal hydrogen carbonates such as potassium hydrogen carbonate; alkali metal carboxylates such as sodium acetate), alkaline earth metal compounds (eg, water). Alkali earth metal hydroxides such as magnesium oxide; alkaline earth metal carbonates such as magnesium carbonate; alkaline earth metal carboxylates such as magnesium acetate) and the like can be blended.
（２）抗菌剤について
本発明の抗菌性洗浄剤用混合物中に使用する抗菌剤としては、優れた抗菌性を有していて、微量で、かつ比較的短時間で効果を発揮できること、人体に対する安全性が高く、無刺激であることなどが必要とされる。
(2) Antibacterial agent The antibacterial agent used in the mixture for an antibacterial cleaning agent of the present invention has excellent antibacterial properties, can exert an effect in a small amount and in a relatively short time, and is effective against the human body. It is required to be highly safe and non-irritating.
分子末端に２個のピリジン環又はキノリン環を有し、かつこれらの環の窒素原子が第４級アンモニウム基となっている化合物の中には、抗菌剤、抗ウィルス性としての機能を有するものも知られているが（特許文献６，７参照）、これらの中でも下記化学式で示される化学名：１，４-ビス（３，３’-(１-デシルピリジニウム）メチルオキシ)ブタンジブロマイド（ＤＰＭＢＢ）は、本発明の抗菌性洗浄剤用混合物に含有されていると、極めて微量でも、抗菌効果の評価に広く使用されている大腸菌、黄色ブドウ球菌に対し優れた抗菌性を示す。上記ＤＰＭＢＢは、融点は７７〜７９℃の常温で白色ないし淡褐色の固体で、水溶性に優れている。 Some compounds having two pyridine rings or quinoline rings at the molecular end and the nitrogen atom of these rings being a quaternary ammonium group have antibacterial and antiviral functions. Is also known (see Patent Documents 6 and 7), but among these, the chemical name represented by the following chemical formula: 1,4-bis (3,3'-(1-decylpyridinium) methyloxy) butanji bromide ( DPMBB), when contained in the antibacterial cleaning agent mixture of the present invention, exhibits excellent antibacterial properties against Escherichia coli and Yellow Drosophila, which are widely used for evaluation of antibacterial effects, even in extremely small amounts. The DPMBB is a white to light brown solid having a melting point of 77 to 79 ° C. at room temperature and has excellent water solubility.
本発明の抗菌性洗浄剤用混合物中の上記抗菌剤の含有量は、洗浄力を発揮する炭酸水素ナトリウムと炭酸ナトリウムが水溶液中で通常１質量％程度の濃度で使用されることを考慮すると、０．０４質量％以上、好ましくは０．０５質量％以上で優れた抗菌効果を発揮する。一方、該抗菌剤の含有量の上限は抗菌効果からは特に限定されないが、経済性等を考慮すると５．０質量％以下が好ましく、２．０質量％以下がより好ましく、１．０質量％以下が更に好ましい。該抗菌剤によるこのような抗菌効果は、洗浄力を発揮する成分として、炭酸水素ナトリウムと炭酸ナトリウムを２５℃におけるｐＨが９．０〜１０．８になる割合に使用した場合に得られる特融の効果である。尚、該抗菌剤は、洗浄剤としてアルカリ金属塩類を使用する場合に、微量含有されていても常に優れた抗菌力を発揮できるとは限らない。例えば、炭酸水素ナトリウム濃度が１質量％の水溶液に、該抗菌剤を１０質量ｐｐｍの濃度になるように溶解させても、大腸菌と黄色ブドウ球菌に対する優れた抗菌性は得られないことは確認されている。また、該抗菌剤は特許文献７において、水溶液又は水乳化体として抗ウィルス性を有すること、及び長期間使用しても耐性菌が発現しないことが確認されている。 The content of the antibacterial agent in the mixture for an antibacterial cleaning agent of the present invention considers that sodium hydrogen carbonate and sodium carbonate, which exhibit detergency, are usually used in an aqueous solution at a concentration of about 1% by mass. An excellent antibacterial effect is exhibited at 0.04% by mass or more, preferably 0.05% by mass or more. On the other hand, the upper limit of the content of the antibacterial agent is not particularly limited from the antibacterial effect, but is preferably 5.0% by mass or less, more preferably 2.0% by mass or less, and 1.0% by mass in consideration of economic efficiency and the like. The following is more preferable. Such an antibacterial effect by the antibacterial agent is obtained when sodium hydrogen carbonate and sodium carbonate are used as components exhibiting detergency at a ratio of pH of 9.0 to 10.8 at 25 ° C. Is the effect of. When an alkali metal salt is used as a cleaning agent, the antibacterial agent may not always exhibit excellent antibacterial activity even if it is contained in a trace amount. For example, it was confirmed that even if the antibacterial agent is dissolved in an aqueous solution having a sodium hydrogen carbonate concentration of 1% by mass so as to have a concentration of 10% by mass, excellent antibacterial properties against Escherichia coli and Staphylococcus aureus cannot be obtained. ing. Further, it has been confirmed in Patent Document 7 that the antibacterial agent has antiviral properties as an aqueous solution or an emulsified product, and that resistant bacteria do not develop even after long-term use.
（３）抗菌性洗浄剤用混合物の製造方法
本発明の抗菌性洗浄剤用混合物の製造方法は特に限定されるものではないが、その具体例として、トロナ鉱石は分解温度が７０℃の固体（白色結晶粉末）で、一方、上記除菌剤の融点は７７〜７９℃であるので、これらの分解温度及び融点以下の温度条件下で、セスキ炭酸ナトリウムをミルで充分に粉砕した後に、上記除菌剤の微粉体を所定量添加して、充分に混合する方法が挙げられる。
(3) Method for Producing Mixture for Antibacterial Cleaning Agent The method for producing the mixture for antibacterial cleaning agent of the present invention is not particularly limited, but as a specific example thereof, Trona ore is a solid having a decomposition temperature of 70 ° C. White crystal powder), on the other hand, since the melting point of the disinfectant is 77 to 79 ° C., the sodium sesquicarbonate is sufficiently pulverized with a mill under these decomposition temperatures and temperature conditions below the melting point, and then the above removal is performed. Examples thereof include a method in which a predetermined amount of fine powder of the fungal agent is added and sufficiently mixed.
以下に本発明を実施例と比較例により具体的に説明する。尚、本発明は以下の実施例に限定されるものではない。本実施例、比較例で使用した試料、試験菌液の調製方法を以下に記載する。
（１）試料
（イ）洗浄剤原料
洗浄効果を発揮する炭酸塩原料（以下、本実施例、比較例において洗浄剤ということがある）として、炭酸水素ナトリウムと炭酸ナトリウムの略等モル混合物であるセスキ炭酸ナトリウム（化学式がＮａＨＣＯ３・Ｎａ２ＣＯ３・２Ｈ２Ｏであるトロナ鉱石を粉砕して得られた粉末状物）を使用した。尚、該洗浄剤原料の１質量％濃度水溶液のｐＨは、２５℃で９．８であった。
Hereinafter, the present invention will be specifically described with reference to Examples and Comparative Examples. The present invention is not limited to the following examples. The methods for preparing the samples and test bacterial solutions used in this example and comparative example are described below.
(1) Sample (a) Cleaning agent raw material As a carbonate raw material exhibiting a cleaning effect (hereinafter, may be referred to as a cleaning agent in this example and comparative example), it is an abbreviated molar mixture of sodium hydrogen carbonate and sodium carbonate. using sodium sesquicarbonate (formula powdery material obtained by crushing the trona ore is NaHCO 3 · Na 2 CO 3 · 2H 2 O). The pH of the 1% by mass aqueous solution of the cleaning agent raw material was 9.8 at 25 ° C.
（ロ）抗菌剤
抗菌剤として、下記化学式の抗菌剤（化学名：１，４-ビス（３，３’-(１-デシルピリジニウム）メチルオキシ)ブタンジブロマイド（ＤＰＭＢＢ）、タマ化学工業（株）製、商品名：ハイジェニア Ｓ−１００）を使用した。
(B) Antibacterial agent As an antibacterial agent, an antibacterial agent having the following chemical formula (chemical name: 1,4-bis (3,3'-(1-decylpyridinium) methyloxy) butane dibromide (DPMBB), Tama Chemical Industry Co., Ltd. ), Product name: Hygenia S-100) was used.
（ハ）試験菌
抗菌効果の評価に広く使用されている下記の２種類の試験菌を用いた。
（ｉ）大腸菌（Escherichia coli NBRC 3972）
（ii）黄色ブドウ球菌（Staphylococcus aureus NBRC 13276）
(C) Test bacteria The following two types of test bacteria, which are widely used for evaluation of antibacterial effect, were used.
(I) Escherichia coli NBRC 3972
(Ii) Staphylococcus aureus NBRC 13276
（２）試験菌液の調製
細菌は普通寒天培地に接種し、３５℃で２４時間培養した。培養後、滅菌生理食戦水を用いて１０８／ミリリットル（ｍｌ）に調製したものを試験菌液とした。
(2) Preparation of test bacterial solution Bacteria were inoculated into a normal agar medium and cultured at 35 ° C. for 24 hours. After culturing, those prepared in 10 8 / ml with sterile physiological saline against water (ml) was tested bacterial solution.
［実施例１〜３］
（１）検体の作製
前記セスキ炭酸ナトリウム濃度が１質量％の水溶液に、上記抗菌剤の濃度が実施例１、２、３において、それぞれ５、１０、１００質量ｐｐｍとなる検体を作製した。
（２）試験菌液の接種および培養
検体１０ｍｌに、上記大腸菌、黄色ブドウ球菌がそれぞれ含まれる試験菌液をそれぞれ０．１ｍｌずつ接種して、２５℃で５分間培養した。
（３）生菌数測定
接種５分後に、試験試料の１０倍希釈系列を、減菌生理食塩水を用いて作製し、これら希釈液を細菌ＳＣＤＬＰ寒天培養地に接種し、３５℃で４８時間培養した。培養後、形成されたコロニーをカウントし、生菌数を換算した。菌体の抗菌試験結果を表１に示した。尚、表中実施例１、３の数値はｎ２、実施例２の数値はｎ３の平均値である。
[Examples 1 to 3]
(1) Preparation of Specimens In the aqueous solution having a sodium sesquicarbonate concentration of 1% by mass, in Examples 1, 2 and 3, samples having a concentration of 5, 10 and 100 mass ppm of the antibacterial agent were prepared.
(2) Inoculation and culturing of test bacterial solution 0.1 ml each of the test bacterial solution containing the above-mentioned Escherichia coli and Staphylococcus aureus was inoculated into 10 ml of the sample and cultured at 25 ° C. for 5 minutes.
(3) Measurement of viable cell count Five minutes after inoculation, a 10-fold dilution series of test samples was prepared using sterilized physiological saline, and these dilutions were inoculated into a bacterial SCDLP agar culture medium at 35 ° C. for 48 hours. It was cultured. After culturing, the formed colonies were counted and the viable cell count was converted. The antibacterial test results of the cells are shown in Table 1. In the table, the numerical values of Examples 1 and 3 are the average values of n2, and the numerical values of Example 2 are the average values of n3.
［比較例１］
（１）検体の作製
前記セスキ炭酸ナトリウム濃度が１質量％の水溶液に、上記抗菌剤を含有させなかった以外は、上記実施例１〜３と同様に検体を作製した。
（２）試験菌液の接種および培養
検体１０ｍｌに、上記大腸菌、黄色ブドウ球菌が含まれる試験菌液をそれぞれ０．１ｍｌずつ接種して、２５℃で５分間培養した。
（３）生菌数測定
接種５分後に、試験試料の１０倍希釈系列を、減菌生理食塩水を用いて作製し、これら希釈液を細菌ＳＣＤＬＰ寒天培養地に接種し、３５℃で４８時間培養した。培養後、形成されたコロニーをカウントし、生菌数を換算した。検体の抗菌試験結果を表２に示した。尚、表中の数値はｎ３の平均値である。
[Comparative Example 1]
(1) Preparation of Specimen A sample was prepared in the same manner as in Examples 1 to 3 except that the antibacterial agent was not contained in the aqueous solution having a sodium sesquicarbonate concentration of 1% by mass.
(2) Inoculation and culture of test bacterial solution 0.1 ml each of the test bacterial solution containing the above-mentioned Escherichia coli and Staphylococcus aureus was inoculated into 10 ml of the sample and cultured at 25 ° C. for 5 minutes.
(3) Measurement of viable cell count Five minutes after inoculation, a 10-fold dilution series of test samples was prepared using sterilized physiological saline, and these dilutions were inoculated into a bacterial SCDLP agar culture medium at 35 ° C. for 48 hours. It was cultured. After culturing, the formed colonies were counted and the viable cell count was converted. The results of the antibacterial test of the sample are shown in Table 2. The numerical values in the table are average values of n3.
［比較例２，３］
（１）検体の作製
炭酸水素ナトリウム濃度が１質量％の水溶液に、上記抗菌剤の濃度が比較例２、３において、それぞれ０、１０質量ｐｐｍとなる検体を作製した。
（２）試験菌液の接種および培養
検体１０ｍｌに、上記大腸菌、黄色ブドウ球菌がそれぞれ含まれる試験菌液をそれぞれ０．１ｍｌずつ接種して、２５℃で５分間培養した。
（３）生菌数測定
接種５分後に、試験試料の１０倍希釈系列を、減菌生理食塩水を用いて作製し、これら希釈液を細菌ＳＣＤＬＰ寒天培養地に接種し、３５℃で４８時間培養した。培養後、形成されたコロニーをカウントし、生菌数を換算した。菌体の抗菌試験結果を表２に示した。尚、表中の数値はｎ３の平均値である。
[Comparative Examples 2 and 3]
(1) Preparation of Specimen A sample having a concentration of the antibacterial agent of 0 to 10 mass ppm in Comparative Examples 2 and 3 was prepared in an aqueous solution having a sodium hydrogen carbonate concentration of 1 mass%, respectively.
(2) Inoculation and culture of test bacterial solution 0.1 ml each of the test bacterial solution containing Escherichia coli and Staphylococcus aureus was inoculated into 10 ml of the sample, and the mixture was cultured at 25 ° C. for 5 minutes.
(3) Measurement of viable cell count Five minutes after inoculation, a 10-fold dilution series of test samples was prepared using sterilized physiological saline, and these dilutions were inoculated into a bacterial SCDLP agar culture medium at 35 ° C. for 48 hours. It was cultured. After culturing, the formed colonies were counted and the viable cell count was converted. The antibacterial test results of the cells are shown in Table 2. The numerical values in the table are average values of n3.
［比較例４］
（１）検体の作製
洗浄剤等、及び上記抗菌剤を含有しない水溶液を検体とした。
（２）試験菌液の接種および培養
検体１０ｍｌに、上記大腸菌、黄色ブドウ球菌がそれぞれ含まれる試験菌液をそれぞれ０．１ｍｌずつ接種して、２５℃で５分間培養した。
（３）生菌数測定
接種５分後に、試験試料の１０倍希釈系列を、減菌生理食塩水を用いて作製し、これら希釈液を細菌ＳＣＤＬＰ寒天培養地に接種し、３５℃で４８時間培養した。培養後、形成されたコロニーをカウントし、生菌数を換算した。菌体の抗菌試験結果を表２に示した。尚、表中の数値はｎ３の平均値である。
[Comparative Example 4]
(1) Preparation of sample A cleaning agent or the like and an aqueous solution containing no antibacterial agent were used as samples.
(2) Inoculation and culturing of test bacterial solution 0.1 ml each of the test bacterial solution containing the above-mentioned Escherichia coli and Staphylococcus aureus was inoculated into 10 ml of the sample and cultured at 25 ° C. for 5 minutes.
(3) Measurement of viable cell count Five minutes after inoculation, a 10-fold dilution series of test samples was prepared using sterilized physiological saline, and these dilutions were inoculated into a bacterial SCDLP agar culture medium at 35 ° C. for 48 hours. It was cultured. After culturing, the formed colonies were counted and the viable cell count was converted. The antibacterial test results of the cells are shown in Table 2. The numerical values in the table are average values of n3.
Claims (7)
２５℃におけるｐＨが９．０〜１０．８であり、前記抗菌性液体洗浄剤中の該抗菌剤の含有量が５〜５００質量ｐｐｍである、ことを特徴とする抗菌性液体洗浄剤。
An antibacterial liquid cleaning agent characterized in that the pH at 25 ° C. is 9.0 to 10.8, and the content of the antibacterial agent in the antibacterial liquid cleaning agent is 5 to 500 parts by mass ppm .
炭酸水素ナトリウムと炭酸ナトリウムの割合は、前記炭酸水素ナトリウムと炭酸ナトリウムを合わせて水溶液中の濃度が１質量％になるように溶解させたときの２５℃におけるｐＨが９．０〜１０．８となる割合であり、
前記抗菌剤の含有量が０．０５〜５．０質量％である抗菌性洗浄剤用混合物を、
２５℃におけるｐＨが９．０〜１０．８、及び該抗菌剤の含有量が５〜５００質量ｐｐｍとなるように水に溶解して、抗菌性液体洗浄剤として使用する、
ことを特徴とする抗菌性洗浄剤用混合物の使用方法。
The ratio of sodium hydrogen carbonate and sodium carbonate is such that the pH at 25 ° C. is 9.0 to 10.8 when the sodium hydrogen carbonate and sodium carbonate are combined and dissolved so that the concentration in the aqueous solution becomes 1% by mass. Is the ratio
A mixture for an antibacterial cleaning agent having an antibacterial agent content of 0.05 to 5.0% by mass .
It is used as an antibacterial liquid cleaning agent by being dissolved in water so that the pH at 25 ° C. is 9.0 to 10.8 and the content of the antibacterial agent is 5 to 500 mass ppm.
A method of using a mixture for an antibacterial cleaning agent.
The method for using the antibacterial cleaning agent mixture according to claim 5 , wherein the raw material of the component composed of sodium hydrogen carbonate and sodium carbonate is trona ore.
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