JP7298908B2 - antibacterial composition - Google Patents
antibacterial composition Download PDFInfo
- Publication number
- JP7298908B2 JP7298908B2 JP2019549277A JP2019549277A JP7298908B2 JP 7298908 B2 JP7298908 B2 JP 7298908B2 JP 2019549277 A JP2019549277 A JP 2019549277A JP 2019549277 A JP2019549277 A JP 2019549277A JP 7298908 B2 JP7298908 B2 JP 7298908B2
- Authority
- JP
- Japan
- Prior art keywords
- acid
- metal salts
- metal salt
- alkali metal
- mass
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000000844 anti-bacterial effect Effects 0.000 title claims description 76
- 239000000203 mixture Substances 0.000 title claims description 62
- -1 alkali metal salts Chemical class 0.000 claims description 139
- 150000003839 salts Chemical class 0.000 claims description 83
- 229910052783 alkali metal Inorganic materials 0.000 claims description 81
- 229910052751 metal Inorganic materials 0.000 claims description 77
- 239000002184 metal Substances 0.000 claims description 77
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 71
- 150000007524 organic acids Chemical class 0.000 claims description 71
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims description 57
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 18
- 229910052791 calcium Inorganic materials 0.000 claims description 18
- 239000011575 calcium Substances 0.000 claims description 18
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical class OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 17
- 235000003704 aspartic acid Nutrition 0.000 claims description 13
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 13
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical class OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 12
- 159000000000 sodium salts Chemical class 0.000 claims description 11
- 230000000845 anti-microbial effect Effects 0.000 claims description 9
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 8
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical group [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 8
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical group [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 8
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 6
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 6
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 4
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 4
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 4
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 3
- 235000011181 potassium carbonates Nutrition 0.000 claims description 3
- 235000015497 potassium bicarbonate Nutrition 0.000 claims description 2
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims description 2
- 239000011736 potassium bicarbonate Substances 0.000 claims description 2
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims description 2
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical class OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 37
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 35
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 27
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 27
- 239000000174 gluconic acid Substances 0.000 description 27
- 235000012208 gluconic acid Nutrition 0.000 description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 27
- 235000011090 malic acid Nutrition 0.000 description 26
- 239000001630 malic acid Substances 0.000 description 26
- 239000000243 solution Substances 0.000 description 26
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical class OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 23
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical class CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 21
- 239000000126 substance Substances 0.000 description 19
- 229960005069 calcium Drugs 0.000 description 16
- 239000001384 succinic acid Substances 0.000 description 14
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical class OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 10
- 229940093915 gynecological organic acid Drugs 0.000 description 8
- 235000005985 organic acids Nutrition 0.000 description 8
- 238000001556 precipitation Methods 0.000 description 8
- 229940079593 drug Drugs 0.000 description 7
- 239000003814 drug Substances 0.000 description 7
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 6
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 6
- 239000002585 base Substances 0.000 description 6
- 239000011734 sodium Substances 0.000 description 6
- 229910052708 sodium Inorganic materials 0.000 description 6
- 229940074404 sodium succinate Drugs 0.000 description 6
- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 description 6
- 235000010323 ascorbic acid Nutrition 0.000 description 5
- 239000011668 ascorbic acid Substances 0.000 description 5
- 229960005070 ascorbic acid Drugs 0.000 description 5
- 229960000686 benzalkonium chloride Drugs 0.000 description 5
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 5
- 239000003973 paint Substances 0.000 description 5
- 229910052913 potassium silicate Inorganic materials 0.000 description 5
- 235000019353 potassium silicate Nutrition 0.000 description 5
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 5
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 4
- 239000004111 Potassium silicate Substances 0.000 description 4
- 239000004115 Sodium Silicate Substances 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 4
- XMXOIHIZTOVVFB-JIZZDEOASA-L disodium;(2s)-2-aminobutanedioate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CC([O-])=O XMXOIHIZTOVVFB-JIZZDEOASA-L 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- NNHHDJVEYQHLHG-UHFFFAOYSA-N potassium silicate Chemical compound [K+].[K+].[O-][Si]([O-])=O NNHHDJVEYQHLHG-UHFFFAOYSA-N 0.000 description 4
- 229910052911 sodium silicate Inorganic materials 0.000 description 4
- AEQDJSLRWYMAQI-UHFFFAOYSA-N 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical group [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 3
- 241000237509 Patinopecten sp. Species 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 3
- 239000003599 detergent Substances 0.000 description 3
- WPUMTJGUQUYPIV-JIZZDEOASA-L disodium (S)-malate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](O)CC([O-])=O WPUMTJGUQUYPIV-JIZZDEOASA-L 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 239000004744 fabric Substances 0.000 description 3
- 239000001508 potassium citrate Substances 0.000 description 3
- 229960002635 potassium citrate Drugs 0.000 description 3
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 3
- 235000011082 potassium citrates Nutrition 0.000 description 3
- 235000020637 scallop Nutrition 0.000 description 3
- 235000019265 sodium DL-malate Nutrition 0.000 description 3
- 235000017550 sodium carbonate Nutrition 0.000 description 3
- 239000000176 sodium gluconate Substances 0.000 description 3
- 235000012207 sodium gluconate Nutrition 0.000 description 3
- 229940005574 sodium gluconate Drugs 0.000 description 3
- 239000001394 sodium malate Substances 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 229920003002 synthetic resin Polymers 0.000 description 3
- 239000000057 synthetic resin Substances 0.000 description 3
- 239000003232 water-soluble binding agent Substances 0.000 description 3
- OQUFOZNPBIIJTN-UHFFFAOYSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;sodium Chemical compound [Na].OC(=O)CC(O)(C(O)=O)CC(O)=O OQUFOZNPBIIJTN-UHFFFAOYSA-N 0.000 description 2
- OPSXJNAGCGVGOG-DKWTVANSSA-L Calcium L-aspartate Chemical compound [Ca+2].[O-]C(=O)[C@@H](N)CC([O-])=O OPSXJNAGCGVGOG-DKWTVANSSA-L 0.000 description 2
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 2
- NVTRPRFAWJGJAJ-UHFFFAOYSA-L EDTA monocalcium salt Chemical compound [Ca+2].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O NVTRPRFAWJGJAJ-UHFFFAOYSA-L 0.000 description 2
- HLCFGWHYROZGBI-JJKGCWMISA-M Potassium gluconate Chemical compound [K+].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O HLCFGWHYROZGBI-JJKGCWMISA-M 0.000 description 2
- 229910004298 SiO 2 Inorganic materials 0.000 description 2
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 description 2
- 235000011092 calcium acetate Nutrition 0.000 description 2
- 239000001639 calcium acetate Substances 0.000 description 2
- 229960005147 calcium acetate Drugs 0.000 description 2
- 235000010376 calcium ascorbate Nutrition 0.000 description 2
- 229940047036 calcium ascorbate Drugs 0.000 description 2
- 239000011692 calcium ascorbate Substances 0.000 description 2
- 229940034055 calcium aspartate Drugs 0.000 description 2
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 description 2
- 239000001354 calcium citrate Substances 0.000 description 2
- 239000004227 calcium gluconate Substances 0.000 description 2
- 235000013927 calcium gluconate Nutrition 0.000 description 2
- 229960004494 calcium gluconate Drugs 0.000 description 2
- 239000001362 calcium malate Substances 0.000 description 2
- OLOZVPHKXALCRI-UHFFFAOYSA-L calcium malate Chemical compound [Ca+2].[O-]C(=O)C(O)CC([O-])=O OLOZVPHKXALCRI-UHFFFAOYSA-L 0.000 description 2
- 229940016114 calcium malate Drugs 0.000 description 2
- 235000011038 calcium malates Nutrition 0.000 description 2
- BLORRZQTHNGFTI-ZZMNMWMASA-L calcium-L-ascorbate Chemical compound [Ca+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] BLORRZQTHNGFTI-ZZMNMWMASA-L 0.000 description 2
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 description 2
- PBUBJNYXWIDFMU-UHFFFAOYSA-L calcium;butanedioate Chemical compound [Ca+2].[O-]C(=O)CCC([O-])=O PBUBJNYXWIDFMU-UHFFFAOYSA-L 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- IDXKSDJIIYUSQP-UHFFFAOYSA-J dimagnesium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Mg+2].[Mg+2].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O IDXKSDJIIYUSQP-UHFFFAOYSA-J 0.000 description 2
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- UEGPKNKPLBYCNK-UHFFFAOYSA-L magnesium acetate Chemical compound [Mg+2].CC([O-])=O.CC([O-])=O UEGPKNKPLBYCNK-UHFFFAOYSA-L 0.000 description 2
- 239000011654 magnesium acetate Substances 0.000 description 2
- 235000011285 magnesium acetate Nutrition 0.000 description 2
- 229940069446 magnesium acetate Drugs 0.000 description 2
- 229940074358 magnesium ascorbate Drugs 0.000 description 2
- 229960001983 magnesium aspartate Drugs 0.000 description 2
- 239000004337 magnesium citrate Substances 0.000 description 2
- 229960005336 magnesium citrate Drugs 0.000 description 2
- 235000002538 magnesium citrate Nutrition 0.000 description 2
- 239000001755 magnesium gluconate Substances 0.000 description 2
- 235000015778 magnesium gluconate Nutrition 0.000 description 2
- 229960003035 magnesium gluconate Drugs 0.000 description 2
- JFQQIWNDAXACSR-UHFFFAOYSA-L magnesium malate Chemical compound [Mg+2].[O-]C(=O)C(O)CC([O-])=O JFQQIWNDAXACSR-UHFFFAOYSA-L 0.000 description 2
- 229940096424 magnesium malate Drugs 0.000 description 2
- AIOKQVJVNPDJKA-ZZMNMWMASA-L magnesium;(2r)-2-[(1s)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2h-furan-3-olate Chemical compound [Mg+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] AIOKQVJVNPDJKA-ZZMNMWMASA-L 0.000 description 2
- IAKLPCRFBAZVRW-XRDLMGPZSA-L magnesium;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate;hydrate Chemical compound O.[Mg+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O IAKLPCRFBAZVRW-XRDLMGPZSA-L 0.000 description 2
- RXMQCXCANMAVIO-CEOVSRFSSA-L magnesium;(2s)-2-amino-4-hydroxy-4-oxobutanoate Chemical compound [H+].[H+].[Mg+2].[O-]C(=O)[C@@H](N)CC([O-])=O.[O-]C(=O)[C@@H](N)CC([O-])=O RXMQCXCANMAVIO-CEOVSRFSSA-L 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 description 2
- 239000004224 potassium gluconate Substances 0.000 description 2
- 235000013926 potassium gluconate Nutrition 0.000 description 2
- 229960003189 potassium gluconate Drugs 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 2
- 239000002453 shampoo Substances 0.000 description 2
- 150000004760 silicates Chemical class 0.000 description 2
- 239000001632 sodium acetate Substances 0.000 description 2
- 235000017281 sodium acetate Nutrition 0.000 description 2
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 2
- 235000010378 sodium ascorbate Nutrition 0.000 description 2
- 229960005055 sodium ascorbate Drugs 0.000 description 2
- 239000001509 sodium citrate Substances 0.000 description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
- 235000011083 sodium citrates Nutrition 0.000 description 2
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 2
- OKUCEQDKBKYEJY-UHFFFAOYSA-N tert-butyl 3-(methylamino)pyrrolidine-1-carboxylate Chemical compound CNC1CCN(C(=O)OC(C)(C)C)C1 OKUCEQDKBKYEJY-UHFFFAOYSA-N 0.000 description 2
- 235000013337 tricalcium citrate Nutrition 0.000 description 2
- PLSARIKBYIPYPF-UHFFFAOYSA-H trimagnesium dicitrate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PLSARIKBYIPYPF-UHFFFAOYSA-H 0.000 description 2
- QLTGEMIEWNAURK-DKWTVANSSA-L (2s)-2-aminobutanedioate;barium(2+) Chemical compound [Ba+2].[O-]C(=O)[C@@H](N)CC([O-])=O QLTGEMIEWNAURK-DKWTVANSSA-L 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 1
- 235000014653 Carica parviflora Nutrition 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- 241000243321 Cnidaria Species 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical class NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical group [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 239000004260 Potassium ascorbate Substances 0.000 description 1
- 241001609918 Pseudocardium sachalinense Species 0.000 description 1
- DJLSRKXNWJVNTA-UHFFFAOYSA-N [Si]([O-])([O-])(O)O.[Si](O)(O)(O)O.[Si](O)(O)(O)O.[K+].[K+] Chemical compound [Si]([O-])([O-])(O)O.[Si](O)(O)(O)O.[Si](O)(O)(O)O.[K+].[K+] DJLSRKXNWJVNTA-UHFFFAOYSA-N 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- ITHZDDVSAWDQPZ-UHFFFAOYSA-L barium acetate Chemical compound [Ba+2].CC([O-])=O.CC([O-])=O ITHZDDVSAWDQPZ-UHFFFAOYSA-L 0.000 description 1
- 229940112016 barium acetate Drugs 0.000 description 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
- 229940006612 barium citrate Drugs 0.000 description 1
- BVHIJPAJAUMNRN-ZZMNMWMASA-L barium(2+) (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2H-furan-3-olate Chemical compound [Ba+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] BVHIJPAJAUMNRN-ZZMNMWMASA-L 0.000 description 1
- PECPTSUHUFWKDG-IYEMJOQQSA-L barium(2+);(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ba+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O PECPTSUHUFWKDG-IYEMJOQQSA-L 0.000 description 1
- DAUQPBPEOBLOBI-UHFFFAOYSA-J barium(2+);2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Ba+2].[Ba+2].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O DAUQPBPEOBLOBI-UHFFFAOYSA-J 0.000 description 1
- PAVWOHWZXOQYDB-UHFFFAOYSA-H barium(2+);2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Ba+2].[Ba+2].[Ba+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PAVWOHWZXOQYDB-UHFFFAOYSA-H 0.000 description 1
- HFAQXXPQBRIXGD-UHFFFAOYSA-L barium(2+);butanedioate Chemical compound [Ba+2].[O-]C(=O)CCC([O-])=O HFAQXXPQBRIXGD-UHFFFAOYSA-L 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- DUMIASQJCCZABP-UHFFFAOYSA-N butanedioic acid;sodium Chemical compound [Na].OC(=O)CCC(O)=O DUMIASQJCCZABP-UHFFFAOYSA-N 0.000 description 1
- 235000001465 calcium Nutrition 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 229960004256 calcium citrate Drugs 0.000 description 1
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 description 1
- 239000000292 calcium oxide Substances 0.000 description 1
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- YKZPPPNXRZHVGX-PXYKVGKMSA-L dipotassium;(2s)-2-aminobutanedioate;hydron;hydrate Chemical compound [H+].[H+].O.[K+].[K+].[O-]C(=O)[C@@H](N)CC([O-])=O.[O-]C(=O)[C@@H](N)CC([O-])=O YKZPPPNXRZHVGX-PXYKVGKMSA-L 0.000 description 1
- CVOQYKPWIVSMDC-UHFFFAOYSA-L dipotassium;butanedioate Chemical compound [K+].[K+].[O-]C(=O)CCC([O-])=O CVOQYKPWIVSMDC-UHFFFAOYSA-L 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 210000003278 egg shell Anatomy 0.000 description 1
- 238000005485 electric heating Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 238000010304 firing Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229940050410 gluconate Drugs 0.000 description 1
- 239000011121 hardwood Substances 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 229940049920 malate Drugs 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 239000011591 potassium Chemical group 0.000 description 1
- 229960003975 potassium Drugs 0.000 description 1
- 229910052700 potassium Chemical group 0.000 description 1
- 235000011056 potassium acetate Nutrition 0.000 description 1
- 235000019275 potassium ascorbate Nutrition 0.000 description 1
- 229940017794 potassium ascorbate Drugs 0.000 description 1
- 229940068988 potassium aspartate Drugs 0.000 description 1
- 229940086066 potassium hydrogencarbonate Drugs 0.000 description 1
- 239000001415 potassium malate Substances 0.000 description 1
- SVICABYXKQIXBM-UHFFFAOYSA-L potassium malate Chemical compound [K+].[K+].[O-]C(=O)C(O)CC([O-])=O SVICABYXKQIXBM-UHFFFAOYSA-L 0.000 description 1
- 235000011033 potassium malate Nutrition 0.000 description 1
- CONVKSGEGAVTMB-RXSVEWSESA-M potassium-L-ascorbate Chemical compound [K+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] CONVKSGEGAVTMB-RXSVEWSESA-M 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 229960001790 sodium citrate Drugs 0.000 description 1
- WPUMTJGUQUYPIV-UHFFFAOYSA-L sodium malate Chemical compound [Na+].[Na+].[O-]C(=O)C(O)CC([O-])=O WPUMTJGUQUYPIV-UHFFFAOYSA-L 0.000 description 1
- 235000019795 sodium metasilicate Nutrition 0.000 description 1
- ZBTUYCUNQBRXOR-UHFFFAOYSA-L sodium succinate hexahydrate Chemical compound O.O.O.O.O.O.[Na+].[Na+].[O-]C(=O)CCC([O-])=O ZBTUYCUNQBRXOR-UHFFFAOYSA-L 0.000 description 1
- HLWRUJAIJJEZDL-UHFFFAOYSA-M sodium;2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetate Chemical compound [Na+].OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC([O-])=O HLWRUJAIJJEZDL-UHFFFAOYSA-M 0.000 description 1
- 239000011122 softwood Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical class [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- JZBRFIUYUGTUGG-UHFFFAOYSA-J tetrapotassium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [K+].[K+].[K+].[K+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O JZBRFIUYUGTUGG-UHFFFAOYSA-J 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
- A01N37/04—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof polybasic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/06—Aluminium; Calcium; Magnesium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
- A23L3/3463—Organic compounds; Microorganisms; Enzymes
- A23L3/3481—Organic compounds containing oxygen
- A23L3/3508—Organic compounds containing oxygen containing carboxyl groups
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
- A23L3/3463—Organic compounds; Microorganisms; Enzymes
- A23L3/3526—Organic compounds containing nitrogen
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
- A23L3/358—Inorganic compounds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/90—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in food processing or handling, e.g. food conservation
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Pest Control & Pesticides (AREA)
- Environmental Sciences (AREA)
- Food Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- Inorganic Chemistry (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Detergent Compositions (AREA)
Description
本発明は、抗菌性組成物に関する。 The present invention relates to antimicrobial compositions.
近年、衛生環境に対する意識の向上から、屋内外での食事の際にウエットシート又はおしぼりが用いられている。また、トイレの使用後に汚れた部分を簡易に除去するためのトイレクリーナが用いられている。 2. Description of the Related Art In recent years, due to increased awareness of sanitary environments, wet sheets or wet towels are used when eating indoors or outdoors. Also, a toilet cleaner is used to easily remove soiled parts after using the toilet.
特許文献１には、水溶性バインダーが添加された原紙シートに対して薬液を含浸させた水解性シートであって、前記原紙シートは、複数枚の原紙をプライ加工したものであり、かつ目付が３０～１５０ｇｓｍであり、広葉樹パルプに対する針葉樹パルプの配合比を１／１未満とし、当該原紙シートの厚み方向内側から表面及び裏面に向かうにつれて前記水溶性バインダーの含有量を増加させた状態とし、前記薬液には、前記水溶性バインダーに架橋反応を起こさせる架橋剤、及び除菌剤を含み、前記原紙シートの重量に対して１５０～３００重量％の前記薬液を含浸させている水解性シートが開示されている。 Patent Document 1 discloses a water-decomposable sheet obtained by impregnating a base paper sheet to which a water-soluble binder is added with a chemical solution, wherein the base paper sheet is obtained by plying a plurality of base paper sheets, and has a basis weight of 30 to 150 gsm, the blending ratio of softwood pulp to hardwood pulp is less than 1/1, and the content of the water-soluble binder is increased from the inner side in the thickness direction of the base paper sheet toward the front surface and the back surface, and Disclosed is a water-decomposable sheet impregnated with 150 to 300% by weight of the chemical solution based on the weight of the base paper sheet, wherein the chemical solution contains a cross-linking agent that causes the water-soluble binder to undergo a cross-linking reaction and a disinfecting agent. It is
また、特許文献２には、下記（Ａ）、（Ｂ）、（Ｃ）、（Ｄ）及び（Ｅ）を含有する抗菌性組成物が開示されている。
（Ａ）キトサン及び／又はその塩
（Ｂ）０．００１～０．１０質量％の第四級アンモニウム塩
（Ｃ）アルコール類
（Ｄ）０．０１～１質量％のベタイン系両性界面活性剤
（Ｅ）水Further, Patent Document 2 discloses an antibacterial composition containing the following (A), (B), (C), (D) and (E).
(A) chitosan and/or its salt (B) 0.001 to 0.10% by mass of quaternary ammonium salt (C) alcohols (D) 0.01 to 1% by mass of a betaine amphoteric surfactant ( E) water
特許文献１の水解性シートは、原紙シートに薬液を含浸させて製造されている。そして、薬液は、特許文献２の抗菌性組成物の如く、一般的に塩化ベンザルコニウム（第四級アンモニウム塩）を水に溶解させて作製されている。 The water-disintegratable sheet of Patent Document 1 is produced by impregnating a base paper sheet with a chemical solution. The chemical solution is generally prepared by dissolving benzalkonium chloride (quaternary ammonium salt) in water, such as the antibacterial composition of Patent Document 2.
しかしながら、塩化ベンザルコニウムを水に溶解させて沈澱を生じさせずに所定濃度の水溶液を作製するためには、製造条件をコントロールする必要があることから、通常、塩化ベンザルコニウムは、水に溶解させて水溶液とした上で供給されている。 However, in order to dissolve benzalkonium chloride in water and prepare an aqueous solution of a predetermined concentration without causing precipitation, it is necessary to control the production conditions. It is supplied after being dissolved to form an aqueous solution.
そのため、塩化ベンザルコニウムの輸送時において、水溶液に含まれる塩化ベンザルコニウム自体の含有量が少量であるにもかかわらず、塩化ベンザルコニウム水溶液の体積及び重量が大きくなり、輸送コスト及び保管コストがかさむという問題点を有している。 Therefore, when benzalkonium chloride is transported, the volume and weight of the aqueous solution of benzalkonium chloride increase even though the content of benzalkonium chloride itself contained in the aqueous solution is small, resulting in transportation and storage costs. There is a problem that it is bulky.
本発明は、沈澱を殆ど生じさせることなく簡単に水に溶解させて薬液を製造することができ、輸送コスト及び保管コストを抑制することができる抗菌性組成物を提供する。 The present invention provides an antibacterial composition that can be easily dissolved in water to produce a drug solution with little precipitation, and that can reduce transportation and storage costs.
本発明の抗菌性組成物は、焼成カルシウム１００質量部と、
クエン酸のアルカリ金属塩、クエン酸のアルカリ土類金属塩、グルコン酸のアルカリ金属塩、グルコン酸のアルカリ土類金属塩、アスコルビン酸のアルカリ金属塩、アスコルビン酸のアルカリ土類金属塩、リンゴ酸のアルカリ金属塩、リンゴ酸のアルカリ土類金属塩、コハク酸のアルカリ金属塩、コハク酸のアルカリ土類金属塩、アスパラギン酸のアルカリ金属塩、アスパラギン酸のアルカリ土類金属塩、酢酸のアルカリ金属塩、酢酸のアルカリ土類金属塩、エチレンジアミン四酢酸のアルカリ金属塩及びエチレンジアミン四酢酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種の有機酸の金属塩１００～６００質量部とを含むことを特徴とする。The antibacterial composition of the present invention contains 100 parts by mass of calcined calcium,
Alkali metal salts of citric acid, alkaline earth metal salts of citric acid, alkali metal salts of gluconic acid, alkaline earth metal salts of gluconic acid, alkali metal salts of ascorbic acid, alkaline earth metal salts of ascorbic acid, malic acid alkali metal salts of malic acid, alkaline earth metal salts of malic acid, alkali metal salts of succinic acid, alkaline earth metal salts of succinate, alkali metal salts of aspartic acid, alkaline earth metal salts of aspartic acid, alkali metal salts of acetic acid 100 to 600 parts by mass of at least one metal salt of an organic acid selected from the group consisting of salts, alkaline earth metal salts of acetic acid, alkali metal salts of ethylenediaminetetraacetic acid and alkaline earth metal salts of ethylenediaminetetraacetic acid. It is characterized by
本発明の抗菌性組成物は、水に溶解させる時の条件を殆ど制御することなく、水に容易に溶解させて、沈澱が殆ど生じていない薬液を製造することができる。そして、得られた薬液は、優れた抗菌性を有している。 INDUSTRIAL APPLICABILITY The antibacterial composition of the present invention can be easily dissolved in water without almost controlling the conditions for dissolution in water, and a drug solution with almost no precipitation can be produced. And the resulting chemical liquid has excellent antibacterial properties.
本発明の抗菌性組成物は、焼成カルシウムと、有機酸の金属塩とを含む。 The antimicrobial composition of the present invention comprises calcined calcium and a metal salt of an organic acid.
（焼成カルシウム）
抗菌性組成物は、焼成カルシウムを含有している。焼成カルシウムとしては、ほたて貝殻焼成カルシウムが好ましい。(calcined calcium)
The antimicrobial composition contains calcined calcium. As the calcined calcium, calcined scallop shell calcium is preferred.
焼成カルシウムは、牡蠣殻、ホタテ貝殻、ホッキ貝殻、卵殻、珊瑚殻などの焼成前の主成分が炭酸カルシウムである動物性由来のカルシウム原料を６００℃以上、好ましくは９００～１２００℃の温度で１５～６０分程度焼成又は通電加熱して得られ、主成分を酸化カルシウムとするものである。 Calcined calcium is an animal-derived calcium raw material whose main component is calcium carbonate before baking, such as oyster shell, scallop shell, surf clam shell, egg shell, coral shell, etc., at a temperature of 600 ° C. or higher, preferably 900 to 1200 ° C. It is obtained by firing or electric heating for about 60 minutes, and contains calcium oxide as the main component.
（有機酸の金属塩）
抗菌性組成物は、有機酸の金属塩を含有している。(Metal salt of organic acid)
Antimicrobial compositions contain metal salts of organic acids.
有機酸の金属塩としては、クエン酸のアルカリ金属塩、クエン酸のアルカリ土類金属塩、グルコン酸のアルカリ金属塩、グルコン酸のアルカリ土類金属塩、アスコルビン酸のアルカリ金属塩、アスコルビン酸のアルカリ土類金属塩、リンゴ酸のアルカリ金属塩、リンゴ酸のアルカリ土類金属塩、コハク酸のアルカリ金属塩、コハク酸のアルカリ土類金属塩、アスパラギン酸のアルカリ金属塩、アスパラギン酸のアルカリ土類金属塩、酢酸のアルカリ金属塩、酢酸のアルカリ土類金属塩、エチレンジアミン四酢酸のアルカリ金属塩及びエチレンジアミン四酢酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種の有機酸の金属塩を含有している。なお、有機酸の金属塩は、単独で用いられても二種以上が併用されてもよい。 Examples of metal salts of organic acids include alkali metal salts of citric acid, alkaline earth metal salts of citric acid, alkali metal salts of gluconic acid, alkaline earth metal salts of gluconic acid, alkali metal salts of ascorbic acid, Alkaline earth metal salts, alkali metal salts of malic acid, alkaline earth metal salts of malic acid, alkali metal salts of succinic acid, alkaline earth metal salts of succinic acid, alkali metal salts of aspartic acid, alkaline earth metal salts of aspartic acid At least one metal salt of an organic acid selected from the group consisting of group metal salts, alkali metal salts of acetic acid, alkaline earth metal salts of acetic acid, alkali metal salts of ethylenediaminetetraacetic acid and alkaline earth metal salts of ethylenediaminetetraacetic acid contains The metal salts of organic acids may be used singly or in combination of two or more.
クエン酸のアルカリ金属塩としては、特に限定されないが、クエン酸ナトリウム、クエン酸カリウムが好ましく、クエン酸カリウムがより好ましい。 Although the alkali metal salt of citric acid is not particularly limited, sodium citrate and potassium citrate are preferable, and potassium citrate is more preferable.
クエン酸のアルカリ土類金属塩としては、特に限定されず、例えば、クエン酸マグネシウム、クエン酸カルシウム、クエン酸バリウムなどが挙げられ、クエン酸マグネシウム及びクエン酸カルシウムが好ましい。 The alkaline earth metal salt of citric acid is not particularly limited, and examples thereof include magnesium citrate, calcium citrate, barium citrate and the like, with magnesium citrate and calcium citrate being preferred.
グルコン酸のアルカリ金属塩としては、特に限定されないが、グルコン酸ナトリウム、グルコン酸カリウムが好ましく、グルコン酸ナトリウムがより好ましい。 The alkali metal salt of gluconic acid is not particularly limited, but sodium gluconate and potassium gluconate are preferred, and sodium gluconate is more preferred.
グルコン酸のアルカリ土類金属塩としては、特に限定されず、例えば、グルコン酸マグネシウム、グルコン酸カルシウム、グルコン酸バリウムなどが挙げられ、グルコン酸マグネシウム及びグルコン酸カルシウムが好ましい。 The alkaline earth metal salt of gluconic acid is not particularly limited, and examples thereof include magnesium gluconate, calcium gluconate and barium gluconate, with magnesium gluconate and calcium gluconate being preferred.
アスコルビン酸のアルカリ金属塩としては、特に限定されないが、アスコルビン酸ナトリウム、アスコルビン酸カリウムが好ましく、アスコルビン酸ナトリウムがより好ましい。 The alkali metal salt of ascorbic acid is not particularly limited, but sodium ascorbate and potassium ascorbate are preferred, and sodium ascorbate is more preferred.
アスコルビン酸のアルカリ土類金属塩としては、特に限定されず、例えば、アスコルビン酸マグネシウム、アスコルビン酸カルシウム、アスコルビン酸バリウムなどが挙げられ、アスコルビン酸マグネシウム及びアスコルビン酸カルシウムが好ましい。 The alkaline earth metal salt of ascorbic acid is not particularly limited, and examples thereof include magnesium ascorbate, calcium ascorbate, barium ascorbate, etc. Magnesium ascorbate and calcium ascorbate are preferred.
リンゴ酸のアルカリ金属塩としては、特に限定されないが、リンゴ酸ナトリウム、リンゴ酸カリウムが好ましく、リンゴ酸ナトリウムがより好ましい。 The alkali metal salt of malic acid is not particularly limited, but sodium malate and potassium malate are preferable, and sodium malate is more preferable.
リンゴ酸のアルカリ土類金属塩としては、特に限定されず、例えば、リンゴ酸マグネシウム、リンゴ酸カルシウム、リンゴ酸バリウムなどが挙げられ、リンゴ酸マグネシウム及びリンゴ酸カルシウムが好ましい。 The alkaline earth metal salt of malic acid is not particularly limited, and examples thereof include magnesium malate, calcium malate, barium malate, etc. Magnesium malate and calcium malate are preferred.
コハク酸のアルカリ金属塩としては、特に限定されないが、コハク酸ナトリウム、コハク酸カリウムが好ましく、コハク酸ナトリウムがより好ましい。 The alkali metal salt of succinic acid is not particularly limited, but sodium succinate and potassium succinate are preferred, and sodium succinate is more preferred.
コハク酸のアルカリ土類金属塩としては、特に限定されず、例えば、コハク酸マグネシウム、コハク酸カルシウム、コハク酸バリウムなどが挙げられ、コハク酸マグネシウム及びコハク酸カルシウムが好ましい。 The alkaline earth metal salt of succinic acid is not particularly limited, and examples thereof include magnesium succinate, calcium succinate and barium succinate, with magnesium succinate and calcium succinate being preferred.
アスパラギン酸のアルカリ金属塩としては、特に限定されないが、アスパラギン酸ナトリウム、アスパラギン酸カリウムが好ましく、アスパラギン酸ナトリウムがより好ましい。 The alkali metal salt of aspartic acid is not particularly limited, but sodium aspartate and potassium aspartate are preferable, and sodium aspartate is more preferable.
アスパラギン酸のアルカリ土類金属塩としては、特に限定されず、例えば、アスパラギン酸マグネシウム、アスパラギン酸カルシウム、アスパラギン酸バリウムなどが挙げられ、アスパラギン酸マグネシウム及びアスパラギン酸カルシウムが好ましい。 The alkaline earth metal salt of aspartic acid is not particularly limited, and examples thereof include magnesium aspartate, calcium aspartate, and barium aspartate, with magnesium aspartate and calcium aspartate being preferred.
酢酸のアルカリ金属塩としては、特に限定されないが、酢酸ナトリウム、酢酸カリウムが好ましく、酢酸ナトリウムがより好ましい。 Although the alkali metal salt of acetic acid is not particularly limited, sodium acetate and potassium acetate are preferable, and sodium acetate is more preferable.
酢酸のアルカリ土類金属塩としては、特に限定されず、例えば、酢酸マグネシウム、酢酸カルシウム、酢酸バリウムなどが挙げられ、酢酸マグネシウム及び酢酸カルシウムが好ましい。 The alkaline earth metal salt of acetic acid is not particularly limited, and examples thereof include magnesium acetate, calcium acetate, barium acetate, etc. Magnesium acetate and calcium acetate are preferred.
エチレンジアミン四酢酸のアルカリ金属塩としては、特に限定されないが、エチレンジアミン四酢酸ナトリウム、エチレンジアミン四酢酸カリウムが好ましく、エチレンジアミン四酢酸ナトリウムがより好ましく、エチレンジアミン四酢酸二ナトリウムが特に好ましい。 The alkali metal salt of ethylenediaminetetraacetic acid is not particularly limited, but sodium ethylenediaminetetraacetate and potassium ethylenediaminetetraacetate are preferred, sodium ethylenediaminetetraacetate is more preferred, and disodium ethylenediaminetetraacetate is particularly preferred.
エチレンジアミン四酢酸のアルカリ土類金属塩としては、特に限定されず、例えば、エチレンジアミン四酢酸マグネシウム、エチレンジアミン四酢酸カルシウム、エチレンジアミン四酢酸バリウムなどが挙げられ、エチレンジアミン四酢酸マグネシウム及びエチレンジアミン四酢酸カルシウムが好ましい。 The alkaline earth metal salt of ethylenediaminetetraacetic acid is not particularly limited, and examples thereof include magnesium ethylenediaminetetraacetate, calcium ethylenediaminetetraacetate, barium ethylenediaminetetraacetate, etc. Magnesium ethylenediaminetetraacetate and calcium ethylenediaminetetraacetate are preferred.
有機酸の金属塩としては、クエン酸のアルカリ金属塩、クエン酸のアルカリ土類金属塩、グルコン酸のアルカリ金属塩、グルコン酸のアルカリ土類金属塩、リンゴ酸のアルカリ金属塩、リンゴ酸のアルカリ土類金属塩、エチレンジアミン四酢酸のアルカリ金属塩及びエチレンジアミン四酢酸のアルカリ土類金属塩が好ましく、クエン酸のアルカリ金属塩、グルコン酸のアルカリ金属塩、グルコン酸のアルカリ土類金属塩、リンゴ酸のアルカリ金属塩、リンゴ酸のアルカリ土類金属塩、エチレンジアミン四酢酸のアルカリ金属塩及びエチレンジアミン四酢酸のアルカリ土類金属塩がより好ましく、リンゴ酸のアルカリ金属塩、リンゴ酸のアルカリ土類金属塩、エチレンジアミン四酢酸のアルカリ金属塩及びエチレンジアミン四酢酸のアルカリ土類金属塩が特に好ましく、エチレンジアミン四酢酸のアルカリ金属塩及びエチレンジアミン四酢酸のアルカリ土類金属塩が最も好ましい。 Examples of metal salts of organic acids include alkali metal salts of citric acid, alkaline earth metal salts of citric acid, alkali metal salts of gluconic acid, alkaline earth metal salts of gluconic acid, alkali metal salts of malic acid, Alkaline earth metal salts, alkali metal salts of ethylenediaminetetraacetic acid and alkaline earth metal salts of ethylenediaminetetraacetic acid are preferred, alkali metal salts of citric acid, alkali metal salts of gluconic acid, alkaline earth metal salts of gluconic acid, apple Alkali metal salts of acids, alkaline earth metal salts of malic acid, alkali metal salts of ethylenediaminetetraacetic acid and alkaline earth metal salts of ethylenediaminetetraacetic acid are more preferred, and alkali metal salts of malic acid and alkaline earth metal salts of malic acid. Salts, alkali metal salts of ethylenediaminetetraacetic acid and alkaline earth metal salts of ethylenediaminetetraacetic acid are particularly preferred, with alkali metal salts of ethylenediaminetetraacetic acid and alkaline earth metal salts of ethylenediaminetetraacetic acid being most preferred.
有機酸の金属塩が、グルコン酸のアルカリ金属塩及びグルコン酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種のグルコン酸の金属塩と、
コハク酸のアルカリ金属塩、コハク酸のアルカリ土類金属塩、リンゴ酸のアルカリ金属塩、リンゴ酸のアルカリ土類金属塩、クエン酸のアルカリ金属塩及びクエン酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種の有機酸の金属塩とを含有していることが好ましい。the organic acid metal salt is at least one metal salt of gluconic acid selected from the group consisting of alkali metal salts of gluconic acid and alkaline earth metal salts of gluconic acid;
The group consisting of alkali metal salts of succinic acid, alkaline earth metal salts of succinic acid, alkali metal salts of malic acid, alkaline earth metal salts of malic acid, alkali metal salts of citric acid and alkaline earth metal salts of citric acid and at least one metal salt of an organic acid selected from
有機酸の金属塩が、グルコン酸のアルカリ金属塩と、
コハク酸のアルカリ金属塩、リンゴ酸のアルカリ金属塩及びクエン酸のアルカリ金属塩からなる群から選ばれた少なくとも一種の有機酸のアルカリ金属塩とを含有していることがより好ましい。a metal salt of an organic acid, an alkali metal salt of gluconic acid;
It is more preferable to contain at least one organic acid alkali metal salt selected from the group consisting of succinic acid alkali metal salts, malic acid alkali metal salts and citric acid alkali metal salts.
有機酸の金属塩が、グルコン酸のナトリウム塩と、
コハク酸のナトリウム塩、リンゴ酸のナトリウム塩及びクエン酸のナトリウム塩からなる群から選ばれた少なくとも一種の有機酸のナトリウム塩とを含有していることが特に好ましい。a metal salt of an organic acid, a sodium salt of gluconic acid;
It is particularly preferable to contain at least one sodium salt of an organic acid selected from the group consisting of sodium succinate, sodium malic acid and sodium citric acid.
有機酸の金属塩が、グルコン酸のアルカリ金属塩及びグルコン酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種のグルコン酸の金属塩と、
コハク酸のアルカリ金属塩、コハク酸のアルカリ土類金属塩、リンゴ酸のアルカリ金属塩及びリンゴ酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種の有機酸の金属塩とを含有していることが好ましい。the organic acid metal salt is at least one metal salt of gluconic acid selected from the group consisting of alkali metal salts of gluconic acid and alkaline earth metal salts of gluconic acid;
and at least one metal salt of an organic acid selected from the group consisting of alkali metal salts of succinic acid, alkaline earth metal salts of succinic acid, alkali metal salts of malic acid and alkaline earth metal salts of malic acid. preferably.
有機酸の金属塩が、グルコン酸のアルカリ金属塩と、
コハク酸のアルカリ金属塩及びリンゴ酸のアルカリ金属塩からなる群から選ばれた少なくとも一種の有機酸のアルカリ金属塩とを含有していることがより好ましい。a metal salt of an organic acid, an alkali metal salt of gluconic acid;
It is more preferable to contain at least one alkali metal salt of an organic acid selected from the group consisting of alkali metal salts of succinic acid and alkali metal salts of malic acid.
有機酸の金属塩が、グルコン酸のナトリウム塩と、
コハク酸のナトリウム塩及びリンゴ酸のナトリウム塩からなる群から選ばれた少なくとも一種の有機酸のナトリウム塩とを含有していることが特に好ましい。a metal salt of an organic acid, a sodium salt of gluconic acid;
It is particularly preferable to contain at least one sodium salt of an organic acid selected from the group consisting of sodium succinate and sodium malic acid.
有機酸の金属塩が、グルコン酸のアルカリ金属塩及びグルコン酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種のグルコン酸の金属塩と、
コハク酸のアルカリ金属塩及びコハク酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種の有機酸の金属塩とを含有していることが好ましい。the organic acid metal salt is at least one metal salt of gluconic acid selected from the group consisting of alkali metal salts of gluconic acid and alkaline earth metal salts of gluconic acid;
It preferably contains at least one metal salt of an organic acid selected from the group consisting of alkali metal salts of succinic acid and alkaline earth metal salts of succinic acid.
有機酸の金属塩が、グルコン酸のアルカリ金属塩と、コハク酸のアルカリ金属塩とを含有していることがより好ましい。 More preferably, the organic acid metal salt contains an alkali metal salt of gluconic acid and an alkali metal salt of succinic acid.
有機酸の金属塩が、グルコン酸のナトリウム塩と、コハク酸のナトリウム塩とを含有していることが特に好ましい。 It is particularly preferred that the metal salt of the organic acid contains the sodium salt of gluconic acid and the sodium salt of succinic acid.
有機酸の金属塩が、グルコン酸の金属塩を含有している場合、有機酸の金属塩中、グルコン酸の金属塩の含有量は、３０～７０質量％が好ましく、３５～６５質量％がより好ましく、４０～６０質量％が特に好ましい。 When the metal salt of an organic acid contains a metal salt of gluconic acid, the content of the metal salt of gluconic acid in the metal salt of the organic acid is preferably 30 to 70% by mass, more preferably 35 to 65% by mass. More preferably, 40 to 60% by mass is particularly preferable.
有機酸の金属塩が、クエン酸のアルカリ金属塩及びクエン酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種のクエン酸の金属塩と、
コハク酸のアルカリ金属塩、コハク酸のアルカリ土類金属塩、リンゴ酸のアルカリ金属塩、リンゴ酸のアルカリ土類金属塩、アスパラギン酸のアルカリ金属塩、アスパラギン酸のアルカリ土類金属塩、エチレンジアミン四酢酸のアルカリ金属塩及びエチレンジアミン四酢酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種の有機酸の金属塩とを含有していることが好ましい。the organic acid metal salt is at least one metal salt of citric acid selected from the group consisting of alkali metal citric acid salts and alkaline earth metal citric acid salts;
Alkali metal salts of succinic acid, alkaline earth metal salts of succinic acid, alkali metal salts of malic acid, alkaline earth metal salts of malic acid, alkali metal salts of aspartic acid, alkaline earth metal salts of aspartic acid, ethylenediamine tetra It preferably contains at least one metal salt of an organic acid selected from the group consisting of alkali metal salts of acetic acid and alkaline earth metal salts of ethylenediaminetetraacetic acid.
有機酸の金属塩が、クエン酸のアルカリ金属塩と、
コハク酸のアルカリ金属塩、リンゴ酸のアルカリ金属塩、アスパラギン酸のアルカリ金属塩及びエチレンジアミン四酢酸のアルカリ金属塩からなる群から選ばれた少なくとも一種の有機酸のアルカリ金属塩とを含有していることがより好ましい。the metal salt of an organic acid is an alkali metal salt of citric acid;
and at least one organic acid alkali metal salt selected from the group consisting of succinic acid alkali metal salts, malic acid alkali metal salts, aspartic acid alkali metal salts and ethylenediaminetetraacetic acid alkali metal salts. is more preferable.
有機酸の金属塩が、クエン酸のナトリウム塩と、
コハク酸のナトリウム塩、リンゴ酸のナトリウム塩、アスパラギン酸のナトリウム塩及びエチレンジアミン四酢酸のナトリウム塩からなる群から選ばれた少なくとも一種の有機酸のナトリウム塩とを含有していることが特に好ましい。a metal salt of an organic acid, a sodium salt of citric acid;
It is particularly preferable to contain at least one sodium salt of an organic acid selected from the group consisting of succinic acid sodium salt, malic acid sodium salt, aspartic acid sodium salt and ethylenediaminetetraacetic acid sodium salt.
有機酸の金属塩が、クエン酸のアルカリ金属塩及びクエン酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種のクエン酸の金属塩と、
コハク酸のアルカリ金属塩、コハク酸のアルカリ土類金属塩、リンゴ酸のアルカリ金属塩及びリンゴ酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種の有機酸の金属塩とを含有していることが好ましい。the organic acid metal salt is at least one metal salt of citric acid selected from the group consisting of alkali metal citric acid salts and alkaline earth metal citric acid salts;
and at least one metal salt of an organic acid selected from the group consisting of alkali metal salts of succinic acid, alkaline earth metal salts of succinic acid, alkali metal salts of malic acid and alkaline earth metal salts of malic acid. preferably.
有機酸の金属塩が、クエン酸のアルカリ金属塩と、
コハク酸のアルカリ金属塩及びリンゴ酸のアルカリ金属塩からなる群から選ばれた少なくとも一種の有機酸のアルカリ金属塩とを含有していることがより好ましい。the metal salt of an organic acid is an alkali metal salt of citric acid;
It is more preferable to contain at least one alkali metal salt of an organic acid selected from the group consisting of alkali metal salts of succinic acid and alkali metal salts of malic acid.
有機酸の金属塩が、クエン酸のナトリウム塩と、
コハク酸のナトリウム塩及びリンゴ酸のナトリウム塩からなる群から選ばれた少なくとも一種の有機酸のナトリウム塩とを含有していることが特に好ましい。a metal salt of an organic acid, a sodium salt of citric acid;
It is particularly preferable to contain at least one sodium salt of an organic acid selected from the group consisting of sodium succinate and sodium malic acid.
有機酸の金属塩が、クエン酸のアルカリ金属塩及びクエン酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種のクエン酸の金属塩と、
コハク酸のアルカリ金属塩及びコハク酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種のコハク酸の金属塩とを含有していることが好ましい。the organic acid metal salt is at least one metal salt of citric acid selected from the group consisting of alkali metal citric acid salts and alkaline earth metal citric acid salts;
It preferably contains at least one succinic acid metal salt selected from the group consisting of succinic acid alkali metal salts and succinic acid alkaline earth metal salts.
有機酸の金属塩が、クエン酸のアルカリ金属塩と、コハク酸のアルカリ金属塩とを含有していることがより好ましい。 More preferably, the organic acid metal salt contains an alkali metal salt of citric acid and an alkali metal salt of succinic acid.
有機酸の金属塩が、クエン酸のナトリウム塩と、コハク酸のナトリウム塩とを含有していることが特に好ましい。 It is particularly preferred that the metal salts of organic acids contain sodium citric acid and sodium succinic acid.
有機酸の金属塩が、クエン酸の金属塩を含有している場合、有機酸の金属塩中、クエン酸の金属塩の含有量は、３０～７０質量％が好ましく、３５～６５質量％がより好ましく、４０～６０質量％が特に好ましい。 When the organic acid metal salt contains a citric acid metal salt, the content of the citric acid metal salt in the organic acid metal salt is preferably 30 to 70% by mass, more preferably 35 to 65% by mass. More preferably, 40 to 60% by mass is particularly preferable.
抗菌性組成物中における有機酸の金属塩の含有量は、焼成カルシウム１００質量部に対して１００質量部以上であり、１５０質量部以上が好ましく、２００質量部以上がより好ましく、２２０質量部以上がより好ましく、２５０質量部以上が特に好ましい。有機酸の金属塩の含有量が１００質量部以上であると、抗菌性組成物は優れた抗菌性を有する。 The content of the metal salt of an organic acid in the antibacterial composition is 100 parts by mass or more, preferably 150 parts by mass or more, more preferably 200 parts by mass or more, and 220 parts by mass or more with respect to 100 parts by mass of calcined calcium. is more preferable, and 250 parts by mass or more is particularly preferable. When the content of the metal salt of an organic acid is 100 parts by mass or more, the antibacterial composition has excellent antibacterial properties.
抗菌性組成物中における有機酸の金属塩の含有量は、焼成カルシウム１００質量部に対して６００質量部以下であり、５００質量部以下が好ましく、４５０質量部以下がより好ましく、３５０質量部以下が特に好ましい。有機酸の金属塩の含有量は、６００質量部以下であると、抗菌性組成物中に有機酸の金属塩を沈澱させることなく溶解させることができる。 The content of the metal salt of an organic acid in the antibacterial composition is 600 parts by mass or less, preferably 500 parts by mass or less, more preferably 450 parts by mass or less, and 350 parts by mass or less with respect to 100 parts by mass of calcined calcium. is particularly preferred. When the content of the metal salt of the organic acid is 600 parts by mass or less, the metal salt of the organic acid can be dissolved in the antibacterial composition without precipitating.
なお、有機酸の金属塩が複数種類含有されている場合は、「有機酸の金属塩の含有量」とは、有機酸の金属塩の総含有量をいう。 When a plurality of types of metal salts of organic acids are contained, the "content of metal salts of organic acids" refers to the total content of metal salts of organic acids.
抗菌性組成物は、焼成カルシウムと有機酸の金属塩とを含有していることから、焼成カルシウムの抗菌性を維持しながら、抗菌性組成物を水中に沈澱を生じさせることなく簡単に溶解させることができる。この際、溶解条件を精密に制御することなく、抗菌性組成物を水に加えるだけで簡単に溶解させて抗菌性を有する薬液を作製することができる。得られた薬液は、温度変化にもかかわらず、抗菌性組成物、特に、焼成カルシウムの沈澱を生じさせることは殆どない。 Since the antibacterial composition contains calcined calcium and a metal salt of an organic acid, the antibacterial composition can be easily dissolved in water without causing precipitation while maintaining the antibacterial properties of the calcined calcium. be able to. In this case, the antibacterial composition can be dissolved simply by adding it to water without precisely controlling the dissolution conditions, and a chemical liquid having antibacterial properties can be prepared. The resulting chemical solution hardly causes precipitation of the antibacterial composition, especially calcined calcium, despite temperature changes.
（炭酸塩、炭酸水素塩及び珪酸塩）
抗菌性組成物は、炭酸塩、炭酸水素塩又は珪酸塩を含有していることが好ましい。抗菌性組成物の抗菌性をより向上させることができると共に、抗菌性組成物に優れた洗浄性を付与することができる。(carbonates, hydrogencarbonates and silicates)
The antimicrobial composition preferably contains carbonates, bicarbonates or silicates. The antibacterial properties of the antibacterial composition can be further improved, and excellent detergency can be imparted to the antibacterial composition.
炭酸塩としては、例えば、炭酸ナトリウム、炭酸カリウムなどが挙げられ、炭酸ナトリウムが好ましい。 Examples of carbonates include sodium carbonate and potassium carbonate, with sodium carbonate being preferred.
炭酸水素塩としては、例えば、炭酸水素ナトリウム、炭酸水素カリウムなどが挙げられ、炭酸水素ナトリウムが好ましい。 Examples of the hydrogencarbonate include sodium hydrogencarbonate and potassium hydrogencarbonate, with sodium hydrogencarbonate being preferred.
珪酸塩としては、例えば、Ｍ2Ｏ／ｎＳｉＯ2（式中、Ｍはナトリウム又はカリウムであり、ｎはＳｉＯ2のモル数である。）で表され、具体的には、オルソ珪酸ナトリウム、オルソ珪酸カリウム、セスキ珪酸ナトリウム、セスキ珪酸カリウム、メタ珪酸ナトリウム、メタ珪酸カリウムや、ＪＩＳ Ｋ１４０８に規定されている１号珪酸ナトリウム、１号珪酸カリウム、２号珪酸ナトリウム、２号珪酸カリウム、３号珪酸ナトリウム、３号珪酸カリウムなどが挙げられ、珪酸ナトリウムが好ましい。The silicate is represented by, for example, M 2 O/n SiO 2 (wherein M is sodium or potassium, and n is the number of moles of SiO 2 ). Potassium silicate, sodium sesquisilicate, potassium sesquisilicate, sodium metasilicate, potassium metasilicate, and No. 1 sodium silicate, No. 1 potassium silicate, No. 2 sodium silicate, No. 2 potassium silicate, No. 3 silicate specified in JIS K1408 sodium, No. 3 potassium silicate, etc., and sodium silicate is preferred.
抗菌性組成物中における有機酸の金属塩の質量と炭酸塩の質量との比（有機酸の金属塩の質量／炭酸塩の質量）は、１～５０が好ましく、２～３０がより好ましく、３～２０がより好ましく、３．５～１０が特に好ましい。有機酸の金属塩の質量と炭酸塩の質量との比（有機酸の金属塩の質量／炭酸塩の質量）が上記範囲内であると、抗菌性組成物の抗菌性を向上させることができると共に、抗菌性組成物に洗浄性を付与することができる。 The ratio of the mass of the metal salt of the organic acid to the mass of the carbonate (mass of the metal salt of the organic acid/mass of the carbonate) in the antibacterial composition is preferably 1 to 50, more preferably 2 to 30. 3 to 20 are more preferred, and 3.5 to 10 are particularly preferred. When the ratio of the mass of the metal salt of the organic acid to the mass of the carbonate (mass of the metal salt of the organic acid/mass of the carbonate) is within the above range, the antibacterial properties of the antibacterial composition can be improved. Along with this, it is possible to impart detergency to the antibacterial composition.
抗菌性組成物中における有機酸の金属塩の質量と炭酸水素塩の質量との比（有機酸の金属塩の質量／炭酸水素塩の質量）は、１～５０が好ましく、２～３０がより好ましく、３～２０がより好ましく、３．５～１０が特に好ましい。有機酸の金属塩の質量と炭酸水素塩の質量との比（有機酸の金属塩の質量／炭酸水素塩の質量）が上記範囲内であると、抗菌性組成物の抗菌性を向上させることができると共に、抗菌性組成物に洗浄性を付与することができる。 The ratio of the mass of the metal salt of the organic acid to the mass of the hydrogencarbonate (mass of the metal salt of the organic acid/mass of the hydrogencarbonate) in the antibacterial composition is preferably 1 to 50, more preferably 2 to 30. Preferably, 3 to 20 is more preferable, and 3.5 to 10 is particularly preferable. When the ratio of the mass of the metal salt of the organic acid to the mass of the hydrogencarbonate (mass of the metal salt of the organic acid/mass of the hydrogencarbonate) is within the above range, the antibacterial properties of the antibacterial composition are improved. In addition, the antibacterial composition can be imparted with detergency.
抗菌性組成物中における有機酸の金属塩の質量と珪酸塩の質量との比（有機酸の金属塩の質量／珪酸塩の質量）は、１～５０が好ましく、２～３０がより好ましく、３～２０が特に好ましく、３．５～１０が最も好ましい。有機酸の金属塩の質量と珪酸塩の質量との比（有機酸の金属塩の質量／珪酸塩の質量）が上記範囲内であると、抗菌性組成物の抗菌性を向上させることができると共に、抗菌性組成物に洗浄性を付与することができる。 The ratio of the mass of the metal salt of the organic acid to the mass of the silicate in the antibacterial composition (mass of the metal salt of the organic acid/mass of the silicate) is preferably 1 to 50, more preferably 2 to 30. 3 to 20 are particularly preferred, and 3.5 to 10 are most preferred. When the ratio of the mass of the metal salt of the organic acid to the mass of the silicate (mass of the metal salt of the organic acid/mass of the silicate) is within the above range, the antibacterial properties of the antibacterial composition can be improved. Along with this, it is possible to impart detergency to the antibacterial composition.
（抗菌性組成物）
抗菌性組成物は、焼成カルシウムと有機酸の金属塩とを汎用の混合手段を用いて混合することによって製造することができる。(Antibacterial composition)
The antibacterial composition can be produced by mixing calcined calcium and a metal salt of an organic acid using a general-purpose mixing means.
抗菌性組成物の使用要領について説明する。抗菌性組成物は、水に溶解させて抗菌性を有する薬液を製造することができる。抗菌性組成物を水中に溶解させるにあたって溶解条件を細かく制御する必要はなく、抗菌性組成物を水中に加えるだけで抗菌性組成物を水中に容易に溶解させることができる。 The usage of the antibacterial composition will be explained. The antibacterial composition can be dissolved in water to produce a drug solution with antibacterial properties. There is no need to finely control the dissolution conditions for dissolving the antibacterial composition in water, and the antibacterial composition can be easily dissolved in water simply by adding the antibacterial composition to water.
薬液中における抗菌性組成物の含有量は、水１００質量部に対して０．０１～１０質量部が好ましく、０．０５～５質量部がより好ましく、０．０７～３質量部がより好ましく、０．０８～２質量部が特に好ましい。 The content of the antibacterial composition in the chemical solution is preferably 0.01 to 10 parts by mass, more preferably 0.05 to 5 parts by mass, and more preferably 0.07 to 3 parts by mass with respect to 100 parts by mass of water. , 0.08 to 2 parts by weight are particularly preferred.
得られた薬液は、抗菌性組成物の沈澱、特に、焼成カルシウムの沈澱を殆ど生じることがない。従って、薬液を用いるにあたって沈殿物のろ過を行う必要はなく、設備及び製造工程の簡略化を図ることができる。 The resulting drug solution hardly causes precipitation of the antibacterial composition, especially precipitation of calcined calcium. Therefore, it is not necessary to filter the precipitate when using the chemical solution, and the facility and manufacturing process can be simplified.
しかも、得られた薬液は、防腐剤の添加を必要とせず、変質することなく長期間に亘って優れた抗菌性を維持しながら安定的に保存することができる。なお、防腐剤としては、一般的に用いられているものが挙げられ、例えば、パラオキシ安息香酸エステル又はその塩類（パラベン類）、フェノキシエタノール、安息香酸又はその塩類、ソルビン酸又はその塩類、及び、グルコン酸クロルヘキシジンなどが挙げられる。 Moreover, the resulting chemical solution does not require the addition of preservatives, and can be stably stored over a long period of time while maintaining excellent antibacterial properties without deterioration. Examples of preservatives include those commonly used, such as paraoxybenzoic acid esters or salts thereof (parabens), phenoxyethanol, benzoic acid or salts thereof, sorbic acid or salts thereof, and gluconate. and chlorhexidine acid.
そして、薬液を布（不織布、織布、編布など）に含浸させることによって抗菌性シートを作製することができる。抗菌性シートは、例えば、おしぼり、清拭シート、トイレクリーナなどとして用いることができる。 Then, an antibacterial sheet can be produced by impregnating cloth (nonwoven fabric, woven cloth, knitted cloth, etc.) with the chemical solution. The antibacterial sheet can be used, for example, as a wet towel, a cleaning sheet, a toilet cleaner, and the like.
また、抗菌性組成物は、人体に有害な化合物を含有していないことから、野菜や果物などの食料品を薬液に浸すことによって、食料品に抗菌性を付与し、保存性を向上させることができる。 In addition, since the antibacterial composition does not contain compounds harmful to the human body, it is possible to impart antibacterial properties to foodstuffs such as vegetables and fruits by soaking them in the chemical solution and improve their preservability. can be done.
更に、薬液を洗浄剤として用いることができ、薬液で手足などの身体を拭くことによって、身体を清潔にすることができる。 Furthermore, a chemical solution can be used as a cleansing agent, and the body can be kept clean by wiping the body such as hands and feet with the chemical solution.
又、洗髪剤（シャンプー）、ヘアリンス及び身体を洗浄するための洗浄剤には水が含まれているので、水に抗菌性組成物を溶解させることによって、洗髪剤、ヘアリンス及び洗浄剤に抗菌性を付与することができ、洗髪剤、ヘアリンス及び洗浄剤を長期間に亘って安定的に保存することができる。 In addition, since water is contained in shampoos, hair rinses, and cleansers for washing the body, the antibacterial properties of the hair cleansers, hair rinses, and cleansers can be enhanced by dissolving the antibacterial composition in water. can be imparted, and the hair shampoo, hair rinse and detergent can be stably stored for a long period of time.
抗菌性組成物は水性塗料に含有させることによって、水性塗料に抗菌性を付与することができる。水性塗料は、水と、水に分散させたバインダー成分とを含有している。抗菌性組成物は、沈澱を殆ど生じさせることなく水に溶解させることができるので、水性塗料中に抗菌性組成物を均一に含有させることができ、得られる塗膜中に均一に含有させて抗菌性を有する塗膜を形成することができる。 By incorporating the antibacterial composition into the water-based paint, antibacterial properties can be imparted to the water-based paint. Aqueous paints contain water and a binder component dispersed in water. Since the antibacterial composition can be dissolved in water with almost no precipitation, the antibacterial composition can be uniformly contained in the water-based paint and uniformly contained in the resulting coating film. A coating film having antibacterial properties can be formed.
抗菌性組成物は、化粧品に含有させて化粧品に抗菌性を付与することもできる。化粧品としては、水を含有しておればよく、例えば、化粧水などが挙げられる。 The antibacterial composition can also be included in cosmetics to impart antibacterial properties to the cosmetics. Cosmetics may include water as long as they contain water, and examples thereof include lotions.
また、抗菌性組成物は、合成樹脂に練り込んで用いてもよい。抗菌性組成物及び合成樹脂を押出機に供給して溶融混練し、押出機から押出して所望形状の成形品（例えば、シート、食品保存袋、日用品、車両内装材、建築用内装材）を成形することによって、抗菌性を有する成形品を得ることができる。 Also, the antibacterial composition may be used by kneading it into a synthetic resin. An antibacterial composition and a synthetic resin are supplied to an extruder, melt-kneaded, and extruded from the extruder to form a molded product (e.g., sheet, food storage bag, daily necessities, vehicle interior material, architectural interior material) in a desired shape. By doing so, a molded article having antibacterial properties can be obtained.
以下に、実施例を用いて本発明をより具体的に説明するが、本発明はこれらの実施例によって限定されない。 EXAMPLES The present invention will be described in more detail below using examples, but the present invention is not limited by these examples.
（実施例１～５、参考例１～３１、比較例１～４）
ほたて貝焼成カルシウム、クエン酸ナトリウム、クエン酸カリウム、グルコン酸ナトリウム、グルコン酸カリウム、リンゴ酸ナトリウム、コハク酸ナトリウム、アスパラギン酸ナトリウム、エチレンジアミン四酢酸二ナトリウム、炭酸ナトリウム、炭酸カリウム、炭酸水素ナトリウム及び珪酸ナトリウムを表１～４に示した所定量ずつ混合することによって抗菌性組成物を作製した。
(Examples 1-5, Reference Examples 1-31 , Comparative Examples 1-4)
Calcined Scallop Calcium, Sodium Citrate, Potassium Citrate, Sodium Gluconate, Potassium Gluconate, Sodium Malate, Sodium Succinate, Sodium Aspartate, Disodium Ethylenediaminetetraacetate, Sodium Carbonate, Potassium Carbonate, Sodium Bicarbonate and Silicic Acid An antibacterial composition was prepared by mixing sodium in predetermined amounts shown in Tables 1-4.
得られた抗菌性組成物の抗菌性及び溶解性を下記の要領で測定し、その結果を表１～４に示した。 The antibacterial activity and solubility of the obtained antibacterial composition were measured in the following manner, and the results are shown in Tables 1-4.
（抗菌性）
抗菌性組成物１質量部を水１０００質量部に添加して溶解させて試験試料を作製した。大腸菌（Escherichia coli）を普通寒天培地に接種し、３５℃にて２４時間に亘って培養した。培養後、滅菌生理食塩水を用いて１０7／ｍＬに調整したものを試験菌液とした。(antibacterial)
A test sample was prepared by adding 1 part by mass of the antibacterial composition to 1000 parts by mass of water and dissolving it. Escherichia coli was inoculated onto a nutrient agar medium and cultured at 35° C. for 24 hours. After culturing, the test bacterial solution was adjusted to 10 7 /mL using sterilized physiological saline.
試験試料２００ｍＬに試験菌液１００μＬ接種して２５℃で培養した。接種５分後及び３０分後に試験試料の１０倍希釈系列を、滅菌生理食塩水を用いて希釈作製したものを試験液とし、この試験液をＳＣＤＬＰ寒天培地に接種し、３５℃にて４８時間培養した。培養後、形成されたコロニーをカウントして生菌数（ｃｆｕ／ｍＬ）を換算した。 100 µL of the test bacterial solution was inoculated into 200 mL of the test sample and cultured at 25°C. 5 minutes and 30 minutes after inoculation, a 10-fold dilution series of the test sample was diluted with sterilized physiological saline to prepare a test solution. cultured. After culturing, the formed colonies were counted and the number of viable cells (cfu/mL) was calculated.
又、滅菌燐酸緩衝生理食塩水をコントロールとして上記と同様の要領で試験を行って生菌数を換算し、初菌数（ｃｆｕ／ｍＬ）とした。
抗菌性（％）＝１００×（初菌数－生菌数）／（初菌数）Using sterilized phosphate-buffered saline as a control, the test was conducted in the same manner as above, and the number of viable bacteria was converted into the initial cell count (cfu/mL).
Antibacterial property (%) = 100 x (initial cell count - viable cell count) / (initial cell count)
（溶解性）
抗菌性組成物０．４質量部を水１００質量部に添加して溶解させて薬液を作製した。得られた薬液を２４時間静置した後、薬液の濁度（ＴＵＲ）を測定器（共立理化学研究所社製 商品名「ＷＡ－ＰＴ－４ＤＧ」）を用いて測定した。なお、薬液の濁度は、ホルマジン溶液を標準液として採用した。濁度が２０ホルマジン度以上である場合は「ＯＶＥＲ」と表記した。(solubility)
A drug solution was prepared by adding 0.4 parts by mass of the antibacterial composition to 100 parts by mass of water and dissolving the mixture. After the resulting chemical solution was allowed to stand for 24 hours, the turbidity (TUR) of the chemical solution was measured using a measuring instrument (trade name “WA-PT-4DG” manufactured by Kyoritsu Scientific Research Institute Co., Ltd.). For the turbidity of the drug solution, a formazin solution was used as a standard solution. When the turbidity was 20 degrees formazin or more, it was described as "OVER".
（関連出願の相互参照）
本出願は、２０１７年１０月１６日に出願された日本国特許出願第２０１７－２００１８１に基づく優先権を主張し、この出願の開示はこれらの全体を参照することにより本明細書に組み込まれる。(Cross reference to related applications)
This application claims priority based on Japanese Patent Application No. 2017-200181 filed on October 16, 2017, and the disclosure of this application is incorporated herein by reference in their entirety.
本発明の抗菌性組成物は、水に容易に溶解させて、薬液を製造することができる。薬液を用いて、抗菌性シートを作製し、又は、食料品に抗菌性を付与することができる。薬液を洗浄剤として用いることもできる。洗浄剤、水性塗料、化粧品及び合成樹脂などの対象物に抗菌性組成物を含有させることによって、対象物に抗菌性を付与することができる。 The antibacterial composition of the present invention can be easily dissolved in water to produce a drug solution. Chemicals can be used to create antimicrobial sheets or to impart antimicrobial properties to foodstuffs. A chemical solution can also be used as a cleaning agent. Antibacterial properties can be imparted to objects such as detergents, water-based paints, cosmetics and synthetic resins by incorporating the antibacterial composition into the objects.
Claims (7)
アスパラギン酸のアルカリ金属塩、及びアスパラギン酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種の有機酸の金属塩１００～６００質量部とを含むことを特徴とする抗菌性組成物。 100 parts by mass of calcined calcium;
An antibacterial composition comprising 100 to 600 parts by mass of at least one metal salt of an organic acid selected from the group consisting of alkali metal salts of aspartic acid and alkaline earth metal salts of aspartic acid.
有機酸の金属塩１００～６００質量部とを含む抗菌性組成物であって、
上記有機酸の金属塩が、クエン酸のアルカリ金属塩及びクエン酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種のクエン酸の金属塩と、
アスパラギン酸のアルカリ金属塩、アスパラギン酸のアルカリ土類金属塩、エチレンジアミン四酢酸のアルカリ金属塩及びエチレンジアミン四酢酸のアルカリ土類金属塩からなる群から選ばれた少なくとも一種の有機酸の金属塩とを含有していることを特徴とする抗菌性組成物。 100 parts by mass of calcined calcium;
An antibacterial composition containing 100 to 600 parts by mass of a metal salt of an organic acid,
wherein the organic acid metal salt is at least one metal salt of citric acid selected from the group consisting of alkali metal citric acid salts and alkaline earth metal citric acid salts;
at least one metal salt of an organic acid selected from the group consisting of alkali metal salts of aspartic acid, alkaline earth metal salts of aspartic acid, alkali metal salts of ethylenediaminetetraacetic acid and alkaline earth metal salts of ethylenediaminetetraacetic acid; An antibacterial composition characterized by containing
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