JP6045942B2 - Solid detergent - Google Patents
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- JP6045942B2 JP6045942B2 JP2013041099A JP2013041099A JP6045942B2 JP 6045942 B2 JP6045942 B2 JP 6045942B2 JP 2013041099 A JP2013041099 A JP 2013041099A JP 2013041099 A JP2013041099 A JP 2013041099A JP 6045942 B2 JP6045942 B2 JP 6045942B2
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Description
本発明は、肌の洗浄用の抗菌性が付与された弱酸性の固形洗浄剤に関する。 The present invention relates to a weakly acidic solid detergent with antibacterial properties for cleaning the skin.
従来、肌の洗浄にはアルカリ性の石鹸や洗浄剤が使用されている。通常、肌のｐＨは５．５前後であり、ｐＨが９〜１０．５を示すアルカリ性の石鹸や洗浄剤で肌を洗浄すると、洗浄後アルカリ性に傾いた肌のｐＨが洗浄前の弱酸性のｐＨまで回復するのに時間を要する。その為、アルカリ性の石鹸や洗浄剤は肌にストレスを与えるリスクがあるといえる。それに対して、ｐＨが６．９以下の弱酸性石鹸は、比較的肌と近いｐＨを示すので、肌の洗浄においてｐＨの影響が小さく、肌への刺激も少ないので、肌の洗浄に好ましいものと考えられている。
このような弱酸性の石鹸として、特許文献１及び２に記載されているようなものが知られている。
ただ、アルカリ性石鹸はｐＨが高いために抗菌効果が認められるのに対して、弱酸性石鹸は抗菌効果が殆ど期待できないというデメリットがある。
Conventionally, alkaline soaps and detergents are used to clean the skin. Usually, the pH of the skin is around 5.5, and when the skin is washed with an alkaline soap or detergent having a pH of 9 to 10.5, the pH of the skin inclined to alkalinity after washing is weakly acidic before washing. It takes time to recover to pH. Therefore, it can be said that alkaline soaps and cleaning agents have a risk of stressing the skin. On the other hand, weakly acidic soaps with a pH of 6.9 or less exhibit a pH that is relatively close to that of the skin, and therefore are less affected by pH and less irritating to the skin. It is believed that.
As such weakly acidic soaps, those described in Patent Documents 1 and 2 are known.
However, the alkaline soap has a high pH and thus has an antibacterial effect, whereas the weakly acidic soap has a demerit that almost no antibacterial effect can be expected.
一方、銀ゼオライトや銀ガラス等の銀系無機抗菌剤が知られている。これらの銀系無機抗菌剤は、安全性が高く、抗菌スペクトルが広く、そして持続性を有するという特徴があり、例えば、抗菌液、消臭液、化粧品、サニタリー製品等の製品に広く使用されている。
そして、本発明者は、先に、銀ゼオライト、クエン酸及び精製水を混合することにより、即効性の抗菌効果を発揮する銀イオン抗菌液を生成できることを見出し、日本国特許庁へ出願を行った。（２０１１年９月１日出願の特願２０１１−１９１０３９号及び２０１３年２月２８日出願の特願２０１３−０３９４８６）
On the other hand, silver-based inorganic antibacterial agents such as silver zeolite and silver glass are known. These silver-based inorganic antibacterial agents are characterized by high safety, wide antibacterial spectrum, and sustainability. For example, they are widely used in products such as antibacterial solutions, deodorant solutions, cosmetics, and sanitary products. Yes.
The present inventor previously found that a silver ion antibacterial solution exhibiting an immediate antibacterial effect can be produced by mixing silver zeolite, citric acid and purified water, and filed an application with the Japan Patent Office. It was. (Japanese Patent Application No. 2011-191039 filed on September 1, 2011 and Japanese Patent Application No. 2013-039486 filed on February 28, 2013)
上記したように、弱酸性石鹸はｐＨが低く抗菌効果が殆ど期待できない。そこで、これまでに殺菌剤として実績があり抗菌活性が高いＴＣＣ等を使用することも考えられるが、このＴＣＣは水に難溶性であるので実用的ではなかった。
そこで、前記した銀ゼオライト、クエン酸及び精製水から生成される銀イオン抗菌液を使用して弱酸性の固形洗浄剤を調製したところ、即効性を持つ非常に強い抗菌効果が認められたので、この銀イオン抗菌液を使用して弱酸性の固形洗浄剤に抗菌効果を付与することとした。つまり、本発明の課題は、抗菌効果を付与した弱酸性の固形洗浄剤を提供することにある。
As described above, the weakly acidic soap has a low pH and almost no antibacterial effect can be expected. Thus, it is conceivable to use TCC or the like that has been used as a bactericidal agent and has high antibacterial activity. However, since TCC is hardly soluble in water, it is not practical.
Therefore, when a weakly acidic solid detergent was prepared using the silver ion antibacterial liquid generated from the above-mentioned silver zeolite, citric acid and purified water, a very strong antibacterial effect having an immediate effect was recognized. This silver ion antibacterial solution was used to give an antibacterial effect to a weakly acidic solid detergent. That is, the subject of this invention is providing the weakly acidic solid cleaning agent which provided the antimicrobial effect.
本発明は、前記した銀イオン抗菌液を使用して抗菌効果を付与した弱酸性の固形洗浄剤を提供するものである。
請求項１に係る抗菌性弱酸性固形洗浄剤は、銀ゼオライトを０．１〜２０．０重量％、及び該銀ゼオライトの重量に対してクエン酸を０．９〜１．５倍の配合量となるように、精製水に配合することにより得た、クエン酸銀錯体及びシリカ水和物を含む混合液である銀イオン抗菌液の固形分が配合されてなる抗菌性弱酸性固形洗浄剤であることを特徴とする。請求項２に係る抗菌性弱酸性固形洗浄剤は、該銀イオン抗菌液は、該銀ゼオライトから生成されたシリカ水和物が除去されてなる請求項１に記載の抗菌性弱酸性固形洗浄剤であることを特徴とする。請求項３に係る抗菌性弱酸性固形洗浄剤は、該銀ゼオライトは、Ａ型又はＸ型の銀ゼオライトであり、銀担持量が０．５〜５．０重量％であることを特徴とする。
This invention provides the weakly acidic solid cleaning agent which provided the antibacterial effect using the above-mentioned silver ion antibacterial liquid.
The antibacterial weakly acidic solid detergent according to claim 1 has a silver zeolite content of 0.1 to 20.0% by weight, and a citric acid content of 0.9 to 1.5 times the weight of the silver zeolite. An antibacterial weakly acidic solid detergent obtained by blending the solid content of a silver ion antibacterial liquid, which is a mixed liquid containing a silver citrate complex and silica hydrate, obtained by blending with purified water It is characterized by being. The antibacterial weakly acidic solid detergent according to claim 2, wherein the silver ion antibacterial liquid is obtained by removing silica hydrate produced from the silver zeolite. It is characterized by being. The antibacterial weakly acidic solid detergent according to claim 3 is characterized in that the silver zeolite is A-type or X-type silver zeolite, and the amount of silver supported is 0.5 to 5.0% by weight. .
本発明の抗菌性弱酸性固形洗浄剤は、弱酸性の洗浄剤なので、肌の洗浄に使用しても肌に対する刺激が極めて少ないという特徴を有すると共に、銀系抗菌剤により抗菌効果が付与される特徴を有する、極めて使用性の良好な抗菌性弱酸性固形洗浄剤として提供することができる。 Since the antibacterial weakly acidic solid detergent of the present invention is a weakly acidic detergent, the antibacterial effect is imparted by the silver antibacterial agent as well as being characterized by extremely little irritation to the skin even when used for cleaning the skin. It can be provided as an antibacterial weakly acidic solid cleaning agent having characteristics and extremely good usability.
本発明の抗菌性弱酸性固形洗浄剤は、通常の弱酸性固形洗浄剤の製造方法に従い、適当量の前記銀イオン抗菌液の固形分を配合して製造することができる。まず、本発明で使用する銀イオン抗菌液の生成方法について、以下に説明する。 The antibacterial weakly acidic solid detergent of the present invention can be produced by blending an appropriate amount of the solid content of the silver ion antibacterial liquid in accordance with a normal method for producing a weakly acidic solid detergent. First, the production | generation method of the silver ion antibacterial liquid used by this invention is demonstrated below.
（銀イオン抗菌液の生成方法）
本発明で使用する銀イオン抗菌液の生成方法は、銀ゼオライトを０．１〜２０．０重量％、該銀ゼオライトの重量に対してクエン酸を０．９〜１．５倍、及び残量を蒸留や濾過、イオン交換等の手法で精製された精製水の配合量とし、撹拌し混合して混合液とすることにより、即効性の抗菌効果を有する銀イオン抗菌液を調製することができる。
上記の工程に加えて、生成したシリカ水和物を沈殿、濾過、遠心分離等の手法で分離し、銀イオン抗菌液を調製しても良い。このようにして生成させた銀イオン抗菌液は、そのまま液体で使用しても良いし、予め乾燥して粉体として使用しても良い。つまり、固形洗浄剤の製造工程において、洗浄剤成分が液状であるときに、銀イオン抗菌液を洗浄剤成分に添加しても良く、また一旦銀イオン抗菌液を乾燥して粉末化した後に固形洗浄剤成分に添加することもできる。
ここで使用する銀ゼオライトは、市販品でも良く、また後述する方法により製造したものでも良いが、Ａ型ゼオライトあるいはＸ型ゼオライトを使用する。これらの銀ゼオライトの銀担持量は、０．５〜５．０重量％が好ましい。
因みに、銀担持量０．５重量％の銀ゼオライト０．１重量％、及びクエン酸０．１５重量％を配合して前記銀イオン抗菌液を製造すると４ｐｐｍ程度の銀イオン濃度となり、銀担持量５．０重量％の銀ゼオライト３．０重量％、及びクエン酸４．５重量％を配合して前記銀イオン抗菌液を製造すると１５００ｐｐｍ程度の銀イオン濃度となる。
なお、上記クエン酸の配合比率は、銀ゼオライトの配合量（重量％）に対するクエン酸の配合量（重量％）の割合、即ち「クエン酸の重量％／銀ゼオライトの重量％」の比率を意味しており、その比率を「配合比率」と定義した。
(Method of producing silver ion antibacterial solution)
The method for producing a silver ion antibacterial solution used in the present invention comprises 0.1 to 20.0% by weight of silver zeolite, 0.9 to 1.5 times citric acid based on the weight of the silver zeolite, and the remaining amount. Can be prepared as a mixture of purified water purified by a technique such as distillation, filtration, ion exchange, etc., and mixed to obtain a silver ion antibacterial solution having an immediate antibacterial effect. .
In addition to the above steps, the produced silica hydrate may be separated by precipitation, filtration, centrifugation, or the like to prepare a silver ion antibacterial solution. The silver ion antibacterial solution thus produced may be used as it is, or may be dried in advance and used as a powder. That is, in the manufacturing process of the solid detergent, when the detergent component is liquid, the silver ion antibacterial liquid may be added to the detergent component, or once the silver ion antibacterial liquid is dried and powdered, It can also be added to the detergent component.
The silver zeolite used here may be a commercially available product or may be one produced by the method described later, but A-type zeolite or X-type zeolite is used. The silver supported amount of these silver zeolites is preferably 0.5 to 5.0% by weight.
Incidentally, when the silver ion antibacterial solution is prepared by blending 0.1% by weight of silver zeolite with 0.5% by weight of silver and 0.15% by weight of citric acid, the silver ion concentration becomes about 4 ppm. When the silver ion antibacterial solution is prepared by blending 3.0% by weight of 5.0% by weight of silver zeolite and 4.5% by weight of citric acid, the silver ion concentration becomes about 1500 ppm.
The citric acid blending ratio means the ratio of citric acid blending amount (wt%) to the silver zeolite blending amount (wt%), that is, the ratio of “citric acid wt% / silver zeolite wt%”. The ratio was defined as “mixing ratio”.
（銀ゼオライトの製造方法）
参考として、銀ゼオライトの製造方法について、以下に説明する。
材料の一例としてＡ型ゼオライトで説明するが、Ｘ型ゼオライトもＡ型ゼオライトと同じ手順で製造できる。なお、以下に説明する銀ゼオライトの製造方法は、従来から知られた製造方法である。
ポリ容器に水を入れ、そこへ少しずつＡ型ゼオライト（Na型）を入れて撹拌し懸濁液を作成し、固体内の空気を出す。所定時間経過後ｐＨを確認する。ｐＨ５〜７になるよう、希硝酸（６倍希釈）を少量ずつ添加し、ｐＨ試験紙にて大まかなｐＨ変化を確認する。
別途、硝酸銀を水に混合しておき、それをＡ型ゼオライトスラリーに撹拌下少しずつ投入する。その後一晩撹拌放置する。
ヌッチェに磁性ロートを設置し、標準濾紙を敷き、そこへ前記銀ゼオライトスラリーを静かに注ぐ。
吸引工程の液切れ前に水で洗浄する。
(Method for producing silver zeolite)
As a reference, a method for producing silver zeolite will be described below.
As an example of the material, A-type zeolite will be described, but X-type zeolite can also be produced by the same procedure as A-type zeolite. In addition, the manufacturing method of the silver zeolite demonstrated below is a manufacturing method known conventionally.
Water is put into a plastic container, and A-type zeolite (Na-type) is gradually added to the container to make a suspension, and air in the solid is discharged. After a predetermined time has passed, check the pH. Dilute nitric acid (diluted 6 times) is added little by little so that the pH is 5 to 7, and a rough pH change is confirmed with a pH test paper.
Separately, silver nitrate is mixed with water, and it is gradually added to the A-type zeolite slurry with stirring. Then leave to stir overnight.
A magnetic funnel is installed in Nutsche, standard filter paper is laid, and the silver zeolite slurry is gently poured into it.
Wash with water before running out of liquid in the suction process.
銀担持量０．５重量％（製造例１）、銀担持量２．５重量％（製造例２）、銀担持量５．０重量％（製造例３）の３種類の銀ゼオライトの製造方法を、製造例として以下に説明する。 Production method of three types of silver zeolite having a silver loading of 0.5% by weight (Production Example 1), a silver loading of 2.5% by weight (Production Example 2), and a silver loading of 5.0% by weight (Production Example 3) Will be described below as a production example.
製造例１；銀担持量０．５重量％の銀ゼオライト
（１）材料
Ａ型ゼオライト（１１０℃乾燥品）：１０００ｇ
硝酸銀（AgNO3）：７．９ｇ
（２）製造の手順
１０Ｌポリ容器に水４．０Ｌを入れ、そこへ少しずつＡ型ゼオライト（Na型）を入れて撹拌し懸濁液を作る。３時間ほど連続して撹拌し、固体内の空気を出す。
所定時間経過後ｐＨを確認する。ｐＨ５〜７になるよう、希硝酸（６倍希釈）を少量ずつ添加し、ｐＨ試験紙にて大まかなｐＨ変化を確認する。
別途、硝酸銀を水３．０Ｌに混合しておき、それをＡ型ゼオライトスラリーに撹拌下少しずつ投入する。その後一晩撹拌放置する。
ヌッチェに磁性ロートを設置し、標準濾紙を敷き、そこへ前記銀ゼオライトスラリーを静かに注ぐ。
吸引工程の液切れ前に５Ｌ水量で洗浄する。
その後１１０℃で一晩乾燥し、冷却後乳鉢で粉砕する。平均粒径が２〜２．５μｍの粉末状のＡ型銀ゼオライトができる。
Production Example 1: Silver zeolite with a silver loading of 0.5% by weight (1) Material Type A zeolite (110 ° C. dried product): 1000 g
Silver nitrate (AgNO 3 ): 7.9 g
(2) Production procedure 4.0 L of water is put into a 10 L plastic container, and A-type zeolite (Na type) is gradually added thereto to stir to make a suspension. Stir continuously for about 3 hours to release air in the solid.
After a predetermined time has passed, check the pH. Dilute nitric acid (diluted 6 times) is added little by little so that the pH is 5 to 7, and a rough pH change is confirmed with a pH test paper.
Separately, silver nitrate is mixed with 3.0 L of water, and it is gradually added to the A-type zeolite slurry with stirring. Then leave to stir overnight.
A magnetic funnel is installed in Nutsche, standard filter paper is laid, and the silver zeolite slurry is gently poured into it.
Wash with 5 L of water before running out of liquid in the suction process.
Then, it is dried overnight at 110 ° C., cooled and ground in a mortar. A powdery A-type silver zeolite having an average particle diameter of 2 to 2.5 μm can be obtained.
製造例２；銀担持量２．５重量％の銀ゼオライト
（１）材料
Ａ型ゼオライト（１１０℃乾燥品）：１０００ｇ
硝酸銀（AgNO3）：３９．７g
（２）製造の手順は上記製造例の手順と同様である。
Production Example 2: Silver zeolite with a weight of 2.5% by weight (1) Material Type A zeolite (dried at 110 ° C.): 1000 g
Silver nitrate (AgNO 3 ): 39.7 g
(2) The manufacturing procedure is the same as that of the above manufacturing example.
製造例３；銀担持量５．０重量％の銀ゼオライト
（１）材料
Ａ型ゼオライト（１１０℃乾燥品）：１０００ｇ
硝酸銀（AgNO3）：７９．５g
（２）製造の手順は上記製造例の手順と同様である。
Production Example 3 Silver zeolite having a weight of 5.0% by weight (1) Material Type A zeolite (dried at 110 ° C.): 1000 g
Silver nitrate (AgNO 3 ): 79.5 g
(2) The manufacturing procedure is the same as that of the above manufacturing example.
次に、本発明の抗菌性弱酸性固形洗浄剤の製造方法について、以下に説明する。
なお、本発明における銀イオン抗菌液の配合量は、洗浄剤中の所望する銀イオン濃度となるように配合すれば良い。
（粉体原料を使用した抗菌性弱酸性固形洗浄剤の製造方法）
常法に従って、銀イオン抗菌液を乾燥した粉末と、その他配合成分を製造釜内にて均一に混合し、粉末状洗浄剤を製造することができる。
（液体原料を使用した抗菌性弱酸性固形洗浄剤の製造方法）
常法に従って、銀イオン抗菌液と、その他配合成分を製造釜内にて均一に混合し、乾燥することにより固形洗浄剤を製造することができる。
なお、本発明の弱酸性固形洗浄剤は、弱酸性の固形石鹸や粉末状石鹸、あるいは、弱酸性のチューブ等に充填されたペースト状のクレンジングフォーム等である。
Next, the manufacturing method of the antibacterial weak acidic solid cleaning agent of this invention is demonstrated below.
In addition, what is necessary is just to mix | blend the compounding quantity of the silver ion antibacterial liquid in this invention so that it may become the desired silver ion density | concentration in a cleaning agent.
(Production method of antibacterial weakly acidic solid detergent using powder raw materials)
According to a conventional method, the powder obtained by drying the silver ion antibacterial solution and other blending components can be uniformly mixed in a production kettle to produce a powdery detergent.
(Method for producing antibacterial weakly acidic solid detergent using liquid raw materials)
A solid detergent can be produced by uniformly mixing a silver ion antibacterial solution and other ingredients in a production kettle and drying in accordance with a conventional method.
The weakly acidic solid detergent of the present invention is a weakly acidic solid soap or powdered soap, or a paste-like cleansing foam filled in a weakly acidic tube or the like.
以下に実施例を示し、本発明の抗菌性弱酸性固形洗浄剤について説明する。
（実施例１）
常法に従って、液状の各配合成分を混合し、アシルグルタミン酸系の透明固形石鹸を製造した。配合した各成分は次の通りである。
ココイルグルタミン酸２３．２重量％、ステアロイルグルタミン酸３．３重量％、ミリストイルグルタミン酸６．６重量％、ヤシ油脂肪酸アルキルイセチオン酸ナトリウム２．０重量％、濃グリセリン１７．０重量％、ヒドロキシエタンジホスホン酸−４ナトリウム０．１重量％、ヒドロキシアルキルエーテルカルボン酸ナトリウム１０．６重量％、４９％濃度水酸化カリウム９．１４重量％、ＴＥＡ（トリエタノールアミン）１３．１重量％、エチルアルコール１２．０重量％、尿素２．０重量％、アルキル変性シリコーン０．５重量％、銀イオン抗菌液０．１重量％の配合量とし、イオン交換水を配合して全量を１００重量％とした。
なお、ここで使用した銀イオン抗菌液は、銀担持量５．０重量％の銀ゼオライト３．０重量％及びクエン酸４．５重量％を配合したものであり、銀イオン濃度は１５００ｐｐｍであった。
An Example is shown below and the antibacterial weakly acidic solid cleaning agent of this invention is demonstrated.
Example 1
According to a conventional method, liquid components were mixed to produce an acylglutamic acid-based transparent solid soap. The blended components are as follows.
Cocoyl glutamic acid 23.2% by weight, stearoyl glutamic acid 3.3% by weight, myristoyl glutamic acid 6.6% by weight, coconut oil fatty acid sodium alkyl isethionate 2.0% by weight, concentrated glycerin 17.0% by weight, hydroxyethane diphosphon Acid-4 sodium 0.1 wt%, hydroxyalkyl ether sodium carbonate 10.6 wt%, 49% strength potassium hydroxide 9.14 wt%, TEA (triethanolamine) 13.1 wt%, ethyl alcohol 12. The blending amount was 0% by weight, 2.0% by weight of urea, 0.5% by weight of alkyl-modified silicone, and 0.1% by weight of silver ion antibacterial solution, and the total amount was 100% by weight by adding ion-exchanged water.
The silver ion antibacterial solution used here was formulated with 3.0% by weight of silver zeolite having a silver loading of 5.0% by weight and 4.5% by weight of citric acid, and the silver ion concentration was 1500 ppm. It was.
（実施例２）
常法に従って、粉体の各配合成分を混合し、粉末状石鹸を製造した。配合した各成分は次の通りである。
Ｎ−ヤシ油脂肪酸アシルグルタミン酸ナトリウム３６．０重量％、ステアロイルグルタミン酸ナトリウム４．０重量％、マンニトール３０．０重量％、ソルビトール１０．０重量％、銀イオン抗菌液粉末０．１重量％の配合量とし、タルクを配合して全量を１００重量％とした。
なお、ここで使用した銀イオン抗菌液粉末は、銀担持量０．５重量％の銀ゼオライト０．１重量％及びクエン酸０．１５重量％を配合した銀イオン抗菌液を乾燥して粉末としたものであり、銀イオン濃度は１５２０ｐｐｍであった。
(Example 2)
According to a conventional method, powdered soaps were prepared by mixing the various components of the powder. The blended components are as follows.
N-coconut oil fatty acid sodium acylglutamate 36.0% by weight, stearoyl sodium glutamate 4.0% by weight, mannitol 30.0% by weight, sorbitol 10.0% by weight, silver ion antibacterial powder 0.1% by weight And talc was blended to make the total amount 100% by weight.
The silver ion antibacterial liquid powder used here is a powder obtained by drying a silver ion antibacterial liquid containing 0.1% by weight of silver zeolite having a silver loading of 0.5% by weight and 0.15% by weight of citric acid. The silver ion concentration was 1520 ppm.
実施例１でアシルグルタミン酸系の透明固形石鹸を蒸留水で溶解（６０℃、１０分処理）して４重量％水溶液を調製し、この水溶液を使用して、以下の通り、抗菌試験を行った。試験方法は、次の通りである。
黄色ブドウ球菌、大腸菌、緑膿菌及びカンジダ菌の各菌液（２×１０5個／ｍｌ滅菌蒸留水）２ｍｌと前記洗浄剤組成物２ｍｌとを混合して混合液とした。そして、この混合液の最終液濃度を１×１０5個／ｍｌ滅菌蒸留水とし、室温暗所で、１５分、３０分及び６０分間反応させた。反応後、各混合液を滅菌蒸留水で１０倍希釈した希釈液０．１ｍｌを各菌の培養培地に塗抹して培養した後、各菌の生菌数を測定した。
なお、培養培地及び培養条件は、黄色ブドウ球菌、大腸菌及び緑膿菌については標準寒天培地で、３０℃、２４時間、カンジダ菌についてはサブロー寒天培地で、２５℃、４８時間とした。
そして、測定した生菌数に応じ、下記の評価基準に従って各組成物の各菌に対する抗菌・抗真菌能を評価した。
In Example 1, an acylglutamic acid-based transparent solid soap was dissolved in distilled water (treated at 60 ° C. for 10 minutes) to prepare a 4% by weight aqueous solution. Using this aqueous solution, an antibacterial test was conducted as follows. . The test method is as follows.
2 ml of each bacterial solution of S. aureus, Escherichia coli, Pseudomonas aeruginosa and Candida (2 × 10 5 cells / ml sterile distilled water) and 2 ml of the detergent composition were mixed to obtain a mixed solution. And the final liquid density | concentration of this liquid mixture was made into 1 * 10 < 5 > piece / ml sterilized distilled water, and it was made to react for 15 minutes, 30 minutes, and 60 minutes at room temperature dark place. After the reaction, 0.1 ml of a diluted solution obtained by diluting each mixed solution 10 times with sterilized distilled water was smeared on the culture medium of each bacterium and cultured, and then the viable cell count of each bacterium was measured.
The culture medium and culture conditions were standard agar medium for S. aureus, Escherichia coli, and Pseudomonas aeruginosa at 30 ° C. for 24 hours, and Candida bacteria were Sabouraud agar medium at 25 ° C. for 48 hours.
Then, according to the measured number of viable bacteria, antibacterial / antifungal ability of each composition was evaluated according to the following evaluation criteria.
評価基準
◎：有効な抗菌・抗真菌能（生菌数＜１０ｃｆｕ／ｍｌ）
○：ほぼ有効な抗菌・抗真菌能（生菌数＜１００ｃｆｕ／ｍｌ）
△：十分ではない抗菌・抗真菌能（生菌数＜１００００ｃｆｕ／ｍｌ）
×：効果の無い抗菌・抗真菌能(菌の死滅なし)
Evaluation criteria A: Effective antibacterial / antifungal ability (viable cell count <10 cfu / ml)
○: Almost effective antibacterial / antifungal ability (viable cell count <100 cfu / ml)
Δ: Insufficient antibacterial / antifungal ability (viable cell count <10000 cfu / ml)
×: Ineffective antibacterial / antifungal ability (no killing of bacteria)
その結果を表１に示す。
銀イオン抗菌液の配合量を０．０７重量％とした以外は同様にして、上記抗菌試験を行った。
その結果を表２に示す。
The results are shown in Table 2.
銀イオン抗菌液の配合量を０．０５重量％とした以外は同様にして、上記抗菌試験を行った。
その結果を表３に示す。
The results are shown in Table 3.
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