WO2019061503A1 - 样本分析仪的清洗控制方法及样本分析仪 - Google Patents

样本分析仪的清洗控制方法及样本分析仪 Download PDF

Info

Publication number
WO2019061503A1
WO2019061503A1 PCT/CN2017/105047 CN2017105047W WO2019061503A1 WO 2019061503 A1 WO2019061503 A1 WO 2019061503A1 CN 2017105047 W CN2017105047 W CN 2017105047W WO 2019061503 A1 WO2019061503 A1 WO 2019061503A1
Authority
WO
WIPO (PCT)
Prior art keywords
cleaning
preset
target device
operation information
cross
Prior art date
Application number
PCT/CN2017/105047
Other languages
English (en)
French (fr)
Inventor
张兴华
周洋
Original Assignee
深圳迈瑞生物医疗电子股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 深圳迈瑞生物医疗电子股份有限公司 filed Critical 深圳迈瑞生物医疗电子股份有限公司
Priority to PCT/CN2017/105047 priority Critical patent/WO2019061503A1/zh
Priority to CN201780092959.4A priority patent/CN110869138B/zh
Publication of WO2019061503A1 publication Critical patent/WO2019061503A1/zh

Links

Images

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B08CLEANING
    • B08BCLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B7/00Cleaning by methods not provided for in a single other subclass or a single group in this subclass
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P90/00Enabling technologies with a potential contribution to greenhouse gas [GHG] emissions mitigation
    • Y02P90/02Total factory control, e.g. smart factories, flexible manufacturing systems [FMS] or integrated manufacturing systems [IMS]

Definitions

  • the invention relates to the technical field of sample analyzers, in particular to a cleaning control method for a sample analyzer and a sample analyzer.
  • the object of the present invention is to provide a sample analyzer cleaning control method and a sample analyzer to optimize the cleaning effect of each device and save resources.
  • the present invention adopts the following technical solutions:
  • a cleaning control method for a sample analyzer comprising the following steps:
  • the target device is cleaned according to the preset cleaning operation information, or according to the target device
  • the historical operation information and the preset operational information clean the target device.
  • the present invention also provides a sample analyzer comprising a control device, a display device, a sample storage device for storing a sample, a detergent storage device for storing a reagent, a dispensing device for sucking up a sample or a reagent, a sample incubation detecting device for sample incubation and detection and a cleaning device for cleaning;
  • the control device includes a processor and a memory, the memory storing a computer program for displaying a preset cleaning parameter table;
  • the processor is configured to obtain current operation information of the current operation step, and the required operation of the current operation step Historical operation information of the target device;
  • the target device is cleaned according to the preset cleaning operation information, or according to the target device
  • the historical operation information and the preset operational information clean the target device.
  • the invention also provides a sample analyzer comprising:
  • a first information acquiring module configured to acquire current operation information of the current operation step, and historical operation information of the target device that is used by the current operation step;
  • a second information acquiring module configured to obtain, according to historical operation information of the target device and current operation information of the current operation step, a historical operation step of the target device from the preset cleaning parameter table, and the a cross-contamination relationship between the current operation steps and a preset cleaning operation information corresponding to the cross-contamination relationship;
  • control module configured to: when the cross-contamination relationship between the historical operation step of the target device and the current operation step is not released, clean the target device according to the preset cleaning operation information, or according to the The historical operation information of the target device and the preset operation information clean the target device.
  • the present invention provides a computer readable storage medium having stored thereon a computer program, the computer program being executed by one or more processors, specifically performing the method of any of the above.
  • the cleaning control method and the sample analyzer of the sample analyzer of the present invention store the cross-contamination relationship between the historical operation steps of each target device and the current operation step in the preset cleaning parameter table and release the cross-contamination relationship.
  • the cleaning operation information is preset, so that when there is a cross-contamination relationship between the historical operation step of the target device and the current operation step, and the cross-contamination is not released, the target device may be performed according to the preset cleaning operation information corresponding to the cross-contamination relationship.
  • FIG. 1 is a flow chart of a cleaning control method of a sample analyzer according to an embodiment of the present invention
  • FIG. 2 is a flow chart of a cleaning control method of a sample analyzer according to an embodiment of the present invention
  • FIG. 3 is a flow chart of a cleaning control method of a sample analyzer according to an embodiment of the present invention.
  • FIG. 4 is a flow chart of a cleaning control method of a sample analyzer according to an embodiment of the present invention.
  • FIG. 5 is a schematic structural diagram of a sample analyzer according to an embodiment of the present invention.
  • Fig. 6 is a block diagram showing the structure of a sample analyzer according to an embodiment of the present invention.
  • An embodiment of the present invention provides a cleaning control method for a sample analyzer for automatically cleaning a target device according to different pollution properties of the target device, solving the pollution condition of the target device, and improving the cleaning effect and saving Resources.
  • the contamination property of the target device can be determined according to whether a chemical reaction occurs between the reagents used by the target device.
  • a cleaning parameter table may be pre-stored on the sample analyzer.
  • the preset cleaning parameter table can record the cross-contamination relationship between various reagents (ie, whether there is a chemical reaction of various reagents), and the preset cleaning operation information required for releasing each cross-contamination relationship, according to the preset cleaning
  • the operation information can be used to know the cleaning operation required to cancel the corresponding cross-contamination relationship.
  • the preset cleaning operation information may include information such as a preset reagent used to cancel the cross-contamination relationship and a preset cleaning times.
  • each cross-contamination relationship corresponds to a preset cleaning operation information, that is, the cross-contamination relationship has a one-to-one correspondence with the cleaning operation required to cancel the cross-contamination relationship, thereby achieving different
  • the targeted cleaning of the cross-contamination relationship ensures the accuracy of the test results, improves the cleaning effect and saves the cleaning agent.
  • the preset cleaning parameter table further includes a pollution source and a pollution object; the pollution source includes one or more types of reagents and/or components, samples or reaction products; the contaminated object includes the type of reagent and/or One or more of the components, samples.
  • the above method includes the following steps:
  • the current operation information of the current operation step includes a target device required to execute the current operation step, and the target device The reagents used by the target device to complete the current procedure.
  • the historical operational information of the target device includes historical operational steps performed by the target device prior to performing the current operational steps, as well as the reagents/cleaning agents used in performing the corresponding historical operational steps, and the number of uses of the reagents/cleaning agents, and the like.
  • the historical operational information of the target device can be the previous operational step of the target device prior to performing the current operational steps, as well as the reagent/cleaning agent used in the previous operational step, and the number of uses of the reagent/cleaning agent, and the like.
  • S200 Obtain a cross-contamination relationship between a historical operation step of the target device and a current operation step, and cancel a cross-contamination relationship according to the historical operation information of the target device and the current operation information of the current operation step, from the preset cleaning parameter table.
  • Preset cleaning operation information may record a cross-contamination relationship between the reagent/cleaning agent used in the historical operation step of the target device and the reagent/cleaning agent used in the current operating step of the target device, and The preset cleaning operation information corresponding to the cross relationship is released.
  • the preset cleaning operation information may include a preset cleaning agent required to cancel the cross-contamination relationship and a preset cleaning number.
  • the processor can find whether there is a cross-contamination relationship between the historical operation steps of the target device and the current operation step by searching the preset cleaning parameter table.
  • the processor is capable of obtaining the intersection between the current operation step and the historical operation step of the target device from the preset cleaning parameter table
  • the target device may be cleaned according to the preset cleaning operation information corresponding to the cross-contamination relationship obtained by the query, so as to cancel the cross-contamination relationship between the historical operation steps of the target device and the current operation step, and ensure the current operation steps.
  • the results are accurate. If the processor does not obtain the cross-contamination relationship between the current operation step and the historical operation step from the preset cleaning parameter table, it can be considered that there is no cross-contamination relationship between the current operation step of the target device and the historical operation step.
  • the cleaning device corresponding to the target device may be controlled to perform the target device according to the preset cleaning operation information in the preset cleaning parameter.
  • the historical operation step of the target device is S1
  • the current operation step is S0.
  • the preset cleaning parameter table can be queried, and the cross-contamination relationship R1 exists between the historical operation step S1 of the target device and the current operation step S0, and is released.
  • the preset cleaning operation information required for the cross-contamination relationship R1 is I1.
  • the target device may be cleaned according to the preset cleaning operation information I1. If the cross-contamination relationship between the current operation step of the target device and the historical operation step has been released, the target device may be controlled to perform the current operation step S0, or the cleaning device corresponding to the target device may be cleaned with a cleaning agent such as water. After the device is cleaned, the target device is controlled to perform the current operation step S0.
  • the target device when the cross-contamination relationship between the historical operation step of the target device and the current operation step is not released, the target device may be cleaned according to the historical operation information of the target device and the preset cleaning operation information. . Further, the target cleaning operation information required to cancel the current cross-contamination relationship may be obtained according to the historical operation information of the target device and the preset cleaning operation, and the target device is cleaned according to the target cleaning operation information, thereby simplifying the cleaning operation of the target device. Specific cleaning control methods can be found in the description below.
  • the historical operational information includes a cleaning agent or sample used for historical operation of the target device, as well as the number of times the cleaning agent/sample is used, and the like.
  • the cleaning control method of the sample analyzer of the present embodiment can simplify the cleaning operation of the sample analyzer by saving only the target device having the cross-contamination relationship, save resources such as reagents or water, optimize the cleaning effect, and improve the cleaning efficiency. .
  • the preset cleaning operation information in the preset cleaning parameter table includes a preset cleaning agent and a preset cleaning frequency
  • the preset cleaning agent may include an acidic cleaning agent, an alkaline cleaning agent, other washing liquid or One or more of the clear water, wherein the other washing liquid refers to an agent having properties other than the acidic cleaning agent and the alkaline cleaning agent.
  • the other cleaning agent can be a reagent containing a surfactant or other solvent.
  • the above-mentioned acidic cleaning agent, alkaline cleaning agent or other washing liquid, which reagent is specifically used can be determined according to the specific cross-contamination relationship.
  • the sorting of the various preset cleanings and priorities may be stored in a preset cleaning parameter table or set to a program default priority ordering.
  • the preset reagent may be preset according to a cross relationship between the current test step of the target device and the historical test step, and the preset reagent should be capable of releasing the cross-contamination relationship described above.
  • the preset number of times of cleaning should be greater than or equal to zero, and the preset number of times of cleaning may be based on a cross-contamination relationship between a current test step and a historical test step of the target device, and a preset reagent used to cancel the cross-contamination relationship.
  • the cleaning effect is preset.
  • the step of cleaning the target device according to the preset cleaning operation information further includes:
  • the cleaned water is used to perform the cleaning operation of the fourth preset cleaning times on the target device.
  • the cleaning method described above is exemplified below, and is only used to clearly illustrate the cleaning method of the present embodiment, and is not used to limit the above cleaning method to the following cleaning methods:
  • the processor may learn from the preset cleaning parameter table that the preset cleaning operation information for releasing the cross-contamination relationship R1 is “preset cleaning agent: acidic cleaning agent; preset cleaning times:
  • the processor may adjust the cleaning device corresponding to the target device according to the preset cleaning operation information when there is an undissolved cross-contamination relationship R1 between the current operation step of the target device and the historical operation step.
  • the acidic cleaning agent is selected, and the target device is cleaned for the first cleaning time, and then washed with water.
  • the processor may learn from the preset cleaning parameter table that the preset cleaning operation information for releasing the cross-contamination relationship R1 is “preset cleaning agent: alkaline cleaning agent; preset cleaning times: The second preset cleaning times", when there is an unresolved cross-contamination relationship R2 between the current operation step of the target device and the historical operation step, the processor may control the cleaning corresponding to the target device according to the preset cleaning operation information.
  • the device uses an alkaline cleaning agent and cleans the target device for a second cleaning cycle, after which it is cleaned with water.
  • the processor may learn from the preset cleaning parameter table that the preset cleaning operation information for releasing the cross-contamination relationship R3 may be: “the first preset cleaning times of the acidic cleaning agent cleaning, and the third The other cleaning agent cleaning of the preset cleaning times, and the water cleaning of the fourth preset cleaning times", when there is an undissolved cross-contamination relationship R3 between the current operating step of the target device and the historical operation step, the processor can follow the pre-prevention
  • the cleaning operation information is set, and the cleaning device corresponding to the target device is first selected with an acidic cleaning agent, and the target device is cleaned for the first cleaning times, and then the other cleaning agent is selected to perform the third predetermined cleaning times for the target device.
  • the fourth predetermined number of cleanings are performed using water cleaning.
  • the processor may also clean the target device according to the preset cleaning operation information and the historical operation information of the target device. For details, refer to the description below.
  • the priority of the plurality of preset cleaning agents may be sorted according to the cleaning effect of each preset cleaning agent, and the priority ordering is obtained.
  • the cleaning effect of each of the preset cleaning agents is obtained according to the amount of use and the number of times of cleaning. For example, if the cleaning is performed with a small amount of acidic cleaning agent or alkaline cleaning agent, the cross-contamination relationship can be released, and if other washing liquids need to be washed three times to release the same cross-contamination relationship, the acidic cleaning agent can be considered as the cross-contamination relationship. Or alkaline cleaners have a higher priority than other lotions.
  • the preset cleaning operation information further includes a priority ordering of the plurality of preset cleaning agents, and the priority ranking of the plurality of preset cleaning agents corresponding to the same cross-contamination relationship is pre-stored in the preset cleaning parameter table.
  • the sample analyzer can flexibly select the cleaning operation according to the preset cleaning parameter table and the actual application scenario, thereby further improving the intelligence degree and being convenient to use.
  • the foregoing method may further include the following steps:
  • the priority order of the one or more preset cleaning agents may be obtained from the preset cleaning parameter table; specifically, Each cross-contamination relationship may be provided with one or more preset cleaning agents that remove the cross-contamination relationship and prioritize the one or more predetermined cleaning agents.
  • the unique preset cleaning agent always has the highest priority.
  • the target cleaning device is cleaned by selecting the preset cleaning agent with the highest priority.
  • the cross-contamination relationship can be effectively eliminated, the secondary pollution can be reduced, and the amount of the preset cleaning agent and/or the number of cleaning can be reduced. Thereby reducing resource waste.
  • the preset cleaning operation information may further include whether to use the cleaning parameter of the preset cleaning agent specified by the preset cleaning operation information, for example, the cleaning parameter may be displayed in a preset manner by “Yes” or “No”. Clean the parameter list.
  • the cleaning parameter in the preset cleaning parameter table is displayed as “Yes”, it may be used to indicate that the pre-cleaning agent needs to be forced to use the preset cleaning operation information specified by the preset cleaning operation information; when the preset cleaning is performed; When the cleaning parameter in the parameter table is displayed as “No”, it can be used to indicate that the cross-contamination relationship is released.
  • an alternative cleaning agent can be used.
  • an alternative cleaning agent can be used instead of the cleaning agent.
  • Use other lotions can be determined according to the actual situation, and is not specifically limited herein.
  • the foregoing method further includes the following steps:
  • S600 Determine whether a preset cleaning agent specified by the preset cleaning operation information is available.
  • S610 Determine whether to use the preset cleaning agent specified by the preset cleaning operation information. Specifically, when the cleaning parameter obtained by the processor from the preset cleaning parameter table is that the preset cleaning agent with the highest priority is required to be used, the pre-specification of the pre-polluting relationship is required to be forced to use the pre-set cleaning operation information. Set a cleaning agent. When the cleaning parameter obtained by the processor from the preset cleaning parameter table is that the preset cleaning agent with the highest priority is not used, the release of the cross-contamination relationship does not require the use of the preset cleaning agent specified by the preset cleaning operation information. It can be replaced with other preset cleaning agents.
  • the step S620 is executed to suspend the cleaning operation of the target device and issue an alarm prompt message until the When the preset cleaning agent specified by the preset cleaning operation information is available, the cleaning operation of the target device is performed.
  • the sample analyzer can also issue an alarm message to remind the staff to replenish the cleaning agent in time.
  • step S700 is performed, according to the preset alternative cleaning operation.
  • Target The parts are cleaned.
  • the preset alternative cleaning operation can eliminate any cross-contamination relationship. Therefore, when the cross-contamination relationship is released without forcing the use of the preset cleaning agent specified by the preset cleaning operation information, the universal alternative cleaning operation can be used for the target.
  • the cleaning operation is performed to simplify the cleaning process of the sample analyzer, saving resources and improving work efficiency.
  • the alternative cleaning operation may be to clean the target device once with other washing liquid; or to clean the target device twice with an acidic cleaning agent; or to clean the target device once with clean water, etc., which is not specifically limited herein.
  • the foregoing method may further include the following steps:
  • the preset cleaning agent specified by the preset cleaning operation information is not available, and the cross-contamination relationship is released, the preset cleaning agent specified by the preset cleaning operation information is not required to be used, and the cleaning is performed according to the preset in the preset cleaning parameter table.
  • the priority order of the agents is selected from a plurality of preset cleaning agents, other than the preset cleaning agents specified by the preset cleaning operation information, and the target device is cleaned by a preset number of cleaning times.
  • the prioritization of various preset cleaning agents that remove the cross-contamination relationship between the current operational steps of the target device and the historical operational steps is: Acid Cleaner > Other Cleaner > Clear Water.
  • acidic cleaning agent is not available, it is judged whether other cleaning agents are available. If other cleaning agents are available, other cleaning agents may be selected to clean the target device. If none of the above various cleaning agents are available, the cleaning operation of the target device is suspended and an alarm message is issued.
  • the above method further includes the following steps:
  • the warning information is marked in the preset cleaning parameter table.
  • the warning information may be identified in a preset cleaning parameter table by means of characters or numbers. In this way, the processor or the user can know the inconsistent cleaning operation, and determine whether the inconsistent cleaning operation affects the accuracy of the current operation result, thereby playing a certain role of pollution risk prediction and control.
  • the preset cleaning operation corresponding to the release of the cross-contamination relationship R1 may be washed twice using the preset cleaning agent A1.
  • the preset cleaning agent A1 is forcibly used, and the preset cleaning agent A1 is available.
  • the cleaning device corresponding to the target device can be controlled to sample the preset cleaning agent A1 to clean the target device twice. If the preset cleaning agent A1 is not available, the cleaning of the target device is stopped and an alarm is issued.
  • the cleaning device corresponding to the target device can be controlled to clean the target device by using a preset alternative cleaning operation.
  • the cross-contamination relationship R1 is released.
  • the processor can also mark in the preset cleaning parameter table to indicate that the actual cleaning operation of the target device does not use the specified preset cleaning agent A1.
  • the preset cleaning operation corresponding to the release of the cross-contamination relationship R1 may be washed once using the preset cleaning agent A2 or Wash twice with the preset cleaning agent A1.
  • the highest priority preset cleaning agent A2 is forced to be used, and the preset cleaning agent A2 is available.
  • the cleaning device corresponding to the target device can be controlled to sample the preset cleaning agent A2 to clean the target device. once. If the preset cleaning agent A2 is not available, the cleaning of the target device is stopped and an alarm is issued.
  • the corresponding cleaning device of the target device can be controlled to use the preset cleaning agent A1 to the target.
  • the device is cleaned twice.
  • the processor can also mark in the preset cleaning parameter table to indicate that the actual cleaning operation of the target device does not use the highest priority preset cleaning agent.
  • step S400 further includes the following steps:
  • the historical operation information of the target device may include information such as historical operation of the target device, and usage times of the cleaning agent and the cleaning agent used in the historical operation.
  • the historical operation information may be operation information corresponding to the previous operation step of the target device before the current operation step, and the operation information of the previous operation step may be stored as a historical operation information of the target device in a preset In the history operation table, the history operation table can be updated in real time.
  • the historical operation information may be all historical operation information of the target device before the current operation step, and the historical operation information may be stored in a preset history operation table, and the history operation table may be updated in real time. That is, each time the target device performs an operation step, the history cleaning parameter table can be updated once.
  • S410 Obtain one or more preset cleaning agents that have been used by the target device and the number of times of cleaning using various preset cleaning agents according to historical operation information of the target device. Specifically, by obtaining the historical operation information of the target device, information such as which cleaning agent and the number of times the cleaning agent is sucked by the target device before the current operation step can be obtained, so that the preset cleaning agent used by the target device can be obtained. The type of cleaning and the number of cleanings that have been cleaned using various preset cleaning agents.
  • S420 determining, according to one or more preset cleaning agents that have been used by the target device and the number of times of cleaning using various preset cleaning agents, determining that the target device is cleaned using the preset cleaning agent specified in the preset cleaning operation information.
  • the number of times that has been cleaned is less than the preset number of cleanings specified in the preset cleaning operation information corresponding to the target device;
  • step S430 may be performed to determine that the cross-contamination between the historical operation step of the target device and the current operation step is not released, and the target needs to be After the device is cleaned, the current operation steps can be performed to avoid the cross-contamination relationship between the current operation steps of the target device and the historical operation steps, and affect the accuracy of the results of the current operation steps.
  • the target device can be directly controlled to perform the current operation step, or the cleaning device of the target device can be controlled to clean the target device by using a common cleaning detergent such as water, and then the target device can be controlled to perform the current operation steps.
  • step S300 further includes:
  • the target cleaning operation information may include a target cleaning agent required to cancel a cross-contamination relationship of the target device, and a target cleaning number of cleaning the target device using the target cleaning agent.
  • the target cleaning agent may be a preset cleaning agent specified in the preset cleaning operation information, and the target cleaning number may be a preset cleaning number specified by the preset cleaning operation information, and the specified preset cleaning agent is used with the target device. The difference in the number of times the cleaning has been performed. When the number of times the target device has been cleaned with the specified preset cleaning agent is zero, the target cleaning number at this time is equal to the preset number of cleaning times specified by the preset cleaning operation information.
  • the preset cleaning operation information required to cancel the cross-contamination relationship between the current operation step of the target device and the historical operation step indicates that the cleaning with the acidic cleaning agent is required twice; and at the same time, the historical operation information of the target device can be known.
  • the target device has been cleaned once with an acidic cleaner.
  • the target cleaning operation information required to cancel the current cross-contamination relationship may be one time using an acidic cleaning agent. This further simplifies the intensive cleaning operation of the target device, saves on cleaning agent and water consumption, saves resources, and improves the efficiency of the sample analyzer by simplifying the cleaning operation steps.
  • step S310 may further include the following steps:
  • the target cleaning agent may be a preset cleaning agent specified in the preset cleaning operation information
  • the target cleaning number may be a preset cleaning number specified by the preset cleaning operation information
  • the specified preset cleaning agent is used with the target device. The difference in the number of times the cleaning has been performed.
  • the target device is cleaned by the number of target cleaning times using the preset cleaning agent specified in the preset cleaning parameters.
  • the preset cleaning operation information required to cancel the cross-contamination relationship between the current operation step of the target device and the historical operation step indicates that the cleaning with the acidic cleaning agent is required twice; and at the same time, the historical operation information of the target device can be known.
  • the target device has been cleaned once with an acidic cleaner.
  • the target cleaning operation information required to cancel the current cross-contamination relationship may be one time using an acidic cleaning agent.
  • step S310 may further include the following steps:
  • the processor may learn from the preset cleaning parameter table that there is a cross-contamination relationship between the current operation step of the target device and which historical operation steps of the target device, and may be released from the preset cleaning parameter table.
  • the preset cleaning operation information required for various cross-contamination relationships that is, the preset cleaning agent required for releasing various cross-contamination relationships and the preset cleaning times for cleaning with a preset cleaning agent.
  • the processor may obtain the target cleaning operation information required to cancel each cross-contamination relationship according to the preset cleaning operation information corresponding to each cross-contamination relationship and the historical operation information of the target device, and the method for obtaining the target cleaning operation information may be specifically referred to The description above.
  • S312. Determine whether the target cleaning operation of the target device can be merged and simplified according to the target cleaning operation information required for various cross-contamination relationships. Specifically, the processor can determine whether the plurality of cross-contamination relationships can be canceled by using the same cleaning operation according to the target cleaning operation information required for various cross-contamination relationships.
  • step S313 is performed to obtain the target with the highest cleaning requirement among the plurality of target cleaning operation information.
  • the cleaning operation information is used to clean the target device according to the target cleaning operation information with the highest cleaning requirement; wherein the cleaning requirement includes the target cleaning agent required to cancel the same cross-contamination relationship, the target cleaning times, and the multiple corresponding to the cross-contamination relationship. Prioritize the target cleaner and whether to force the target cleaner specified in the preset cleaning operation information.
  • step S314 may be performed to clean the target device according to the target cleaning operation information corresponding to the various cross-contamination relationships until all cross-contamination relationships are released. .
  • the control target device directly performs the current operation step without performing the cleaning operation.
  • the cross-contamination relationship between the historical operation steps of the target device and the current operation step has been released, it is not necessary to insert an enhanced cleaning step, and the target device can be controlled to perform the current operation steps.
  • the current operation step may be directly performed, or the cleaning device may be cleaned by using a common cleaning method such as clean water, and then controlled. The target device performs the current operational steps.
  • the processor can learn from the preset cleaning parameter table that there is a cross-contamination relationship R1 between the current operation step and the historical operation step of the target device, and the cleaning operation steps required to cancel the cross-contamination relationship are:
  • Use The cleaning agent A is preset to clean the target device twice.
  • the processor can obtain historical operation information of the target device, and learn from the historical operation information that the target device has been cleaned twice by using the preset cleaning agent A, and the processor can correspond to the cross-contamination relationship R1 of the target device.
  • the preset cleaning operation information and the historical operation information of the target device determine that the cross-contamination relationship R1 between the current operation step of the target device and the historical operation step has been released, and the current operation step can be directly performed, or the cleaning device is adopted.
  • the cleaning device is cleaned by a common cleaning method such as clean water, and then the target device is controlled to perform the current operation steps.
  • a similar method can be used to judge whether the cross-contamination relationship is released.
  • the cleaning device can clean the target device by using ordinary cleaning methods such as clean water, and then control the target device to perform the current operation steps.
  • the foregoing method further includes the following steps:
  • step S500 is performed.
  • the target device is normally cleaned according to a preset normal cleaning operation. Specifically, if the processor does not obtain the cross-contamination relationship between the historical operation step of the target device and the current operation step from the preset cleaning parameter table, it may be described between the historical operation step of the target device and the current operation step. There is no cross-contamination. At this time, the target device can be cleaned normally according to the preset normal cleaning operation, and then the target device is controlled to perform the current operation steps.
  • the above-mentioned ordinary cleaning operation may be an operation of cleaning the target device with clean water.
  • the above-mentioned ordinary cleaning operation may also be an operation of cleaning with a cleaning agent other than the above-mentioned preset cleaning agent.
  • the cleaning control method of the sample analyzer of the present embodiment can simplify the cleaning operation of the sample analyzer by saving only the target device having the cross-contamination relationship, save resources such as reagents or water, optimize the cleaning effect, and improve the cleaning efficiency. .
  • the above target device may be a reaction vessel, a stirrer, a reagent needle or a sampling needle.
  • the reaction vessel may be a reaction cup, a test tube or a sample slide, etc.
  • the stirrer may be a stirring rod or the like.
  • the target cleaning operation information of the target device can be obtained according to the preset cleaning parameter table and the historical operation information of the target device, and the target device is cleaned according to the target cleaning operation, and the specific cleaning method is performed.
  • the cleaning method of any of the above embodiments can be employed.
  • the number of the above-mentioned respective target devices may be plural, and each of the target devices may be cleaned according to the above-described cleaning method.
  • the method before the step of acquiring current operation information of the current operation step, the method further includes the following steps:
  • test information of the current test item includes one or more operation steps
  • the preset first number of target devices are cleaned according to the preset cleaning parameter table, and then the test item is executed;
  • the preset first quantity is greater than or equal to the number of target devices required by the current test item, and the preset first quantity is smaller than the number of target devices available on the sample analyzer. That is, in this embodiment, the current test item requires several target devices, and then several target devices are cleaned instead of cleaning all the target devices at one time, thereby reducing the amount of cleaning agent and water used, saving resources, and Improve the efficiency of the sample analyzer by reducing the cleaning step.
  • the target device is a reagent needle
  • the cleaning agent that needs to be aspirated in the current dispensing step of the reagent needle can be obtained.
  • the processor can obtain historical dispensing information of the reagent needle to know which cleaning agent the reagent needle has taken before the current dispensing step. Specifically, after the reagent needle sucks up the cleaning agent a1, the reagent needle needs to continue to suck and discharge the cleaning agent b1 in accordance with the test sequence.
  • the preset cleaning parameter table can be inquired to know that there is a cross-contamination relationship r1 between the cleaning agent a1 and the dispensing cleaning agent b1 and a preset required to cancel the cross-contamination relationship r1.
  • Cleaning operation information For example, the cleaning operation corresponding to the preset cleaning operation information required to cancel the cross-contamination relationship r1 is to clean once with an acidic cleaning agent.
  • the processor can know through the historical dispensing information of the reagent needle that between the two suction and discharge operations of the reagent needle (between the suction cleaning agent a1 and the suction cleaning agent b1), the reagent needle is not subjected to the suction and discharge to eliminate the cross-contamination relationship r1.
  • the operation of the required acidic cleaning agent can be judged that the cross-contamination relationship has not been released.
  • the reagent needle can be first cleaned with an acidic cleaning agent, and then the reagent needle is sucked and discharged to the cleaning agent b1.
  • the cleaning operation of the reagent needle is suspended and an alarm is issued. If the acidic cleaning agent is not available at this time, and the cross-contamination relationship r1 is released, it is not necessary to force the use of the acidic cleaning agent, and the reagent needle can be cleaned according to a preset alternative cleaning operation.
  • the reagent needle can be cleaned using a common cleaning agent such as clean water. Then, the control reagent needle is sucked and dispensed with the cleaning agent b1. Alternatively, when there is no cross-contamination relationship between the cleaning agent a1 and the cleaning agent b1, or when the cross-contamination relationship r1 has been released, the reagent needle can be controlled to directly perform the current dispensing step.
  • the number of the reagent needles may be plural, and each of the reagent needles may be washed according to the above-described cleaning method.
  • all cross-contamination relationships between the current dispensing step of the reagent needle and its historical dispensing step must be eliminated before it performs the current dispensing step. If there is an unresolved cross-contamination relationship and the cleaning agent that cancels the cross-contamination relationship is not available, the current dispensing step can be assigned to other reagent needles that have been decontaminated.
  • the number of the reagent needles may be two.
  • the two reagent needles may be respectively recorded as the first reagent needle and the second reagent needle, wherein the cross-contamination relationship r1 on the first reagent needle has been released.
  • the cross-contamination relationship r1 on the second reagent needle has not been released, and the current dispensing step can be assigned to the first reagent needle. If the cross-contamination relationship r1 on both reagent needles is not released, the cleaning operation of the two reagent needles can be suspended and an alarm can be issued.
  • the target device is a reaction container
  • the sample to be added to the reaction cup in the current operation step can be obtained before the sample or cleaning agent is filled into the reaction cup.
  • the processor can also obtain historical test information of the cuvette, and the historical test information can include which cleaning agent or sample the cuvette holds before the current operation step.
  • the processor can be based on the current test step before performing the current test step
  • the sample/cleaning agent c1 that needs to be added to the reaction cup before, and the cleaning agent/samples d1, e1 and f1 that the reaction cup has contacted before the current operation step obtain the current need to the reaction cup from the preset cleaning parameter table.
  • the processor can obtain whether the reaction cup has been subjected to the cleaning operation corresponding to the cross-contamination relationship r2 and r3 before the current operation step according to the historical test information passing through the reaction cup, thereby judging whether the cross-contamination relationship r2 and r3 have been Was released.
  • the preset cleaning parameter table it can be known that the above-mentioned cross-contamination relationship r2 needs to be cleaned twice with an acidic cleaning agent, and the above-mentioned cross-contamination relationship r3 needs to be cleaned once with an acidic cleaning agent.
  • the cuvette has not been subjected to the cleaning operation of releasing the cross-contamination relationship r2 and r3, and since the pre-cleaning relationship r2 and r3 are the same as the preset cleaning agent, the acidic cleaning agent can be used.
  • the reaction cup was washed twice to pass the above-mentioned cross-contamination relationship r2 and r3 simultaneously.
  • the above-mentioned cross-contamination relationship r2 needs to be washed twice with an alkaline cleaning agent, and the above-mentioned cross-contamination relationship r3 needs to be washed once with an acidic cleaning agent or an alkaline cleaning agent, and the intersection is released.
  • the pollution relationship r3 does not mandate the use of higher priority acidic cleaners.
  • the reaction cup has been cleaned with an alkaline cleaning agent, and the reaction cup can be cleaned once with an alkaline cleaning agent to simultaneously cancel the above-mentioned cross-contamination relationship r2 and r3.
  • the first number of reaction vessels may be cleaned, wherein the first amount is less than that available on the sample analyzer The number of reaction vessels.
  • the cleaning operation information of the reaction container may be obtained from the preset cleaning parameter table according to the current testing step and the historical testing step of the reaction container, so that each of the cleaning operation information is The reaction vessel is subjected to targeted cleaning, as described in detail above.
  • the target device can also be a sampling needle. Since the sampling needle may come into contact with the added cleaning agent/sample in the reaction container during the sampling, the cleaning agent/sample contacted by the sampling needle may be cross-contaminated with the current sampling step. The sampling needle needs to be cleaned before the sampling needle performs the current sampling step to completely eliminate the cross-contamination relationship.
  • the cleaning control of the sampling needle can be similar to the cleaning control method of the reagent needle described above, and specifically can be referred to the description above.
  • the target device may also be a stirrer or the like, and the number of the agitators may be plural.
  • the specific control method is similar to the control method of the above sampling needle, and the specific description can be found in the above description.
  • the above method further comprises the following steps:
  • the preset cleaning parameter table is displayed on the interactive display interface.
  • the preset cleaning parameter table can be displayed to the user through the interactive display interface, so that the user can intuitively know the cleaning operation.
  • the interactive display interface can be displayed on a display of a terminal connected to the sample analyzer, such as a display of a computer, a mobile phone, or the like.
  • the interaction can also be displayed on the display device on the sample analyzer, which is not specifically limited herein.
  • the parameter update information of the preset cleaning parameter table is obtained through the interactive display interface.
  • the user may increase or decrease the preset cleaning operation information and the cross-contamination relationship in the preset cleaning parameter table displayed on the interactive display interface. Or modify.
  • the processor may obtain parameter update information of the preset cleaning parameter table according to the modification operation, and store the parameter update information correspondingly. In this way, the user can adjust the cleaning parameter table according to the actual test item, so that the sample analyzer can be applied to a plurality of different test items, and the versatility of the instrument is improved.
  • the updated cleaning parameter table is obtained, and the updated cleaning parameter table is displayed on the interactive display interface; optionally, after the preset cleaning parameter table is updated, The updated cleaning parameter table is displayed on the interactive display interface for the user to use.
  • the cross-contamination relationship between the historical operation step of the target device and the current operation step, and the preset cleaning operation information corresponding to the cross-contamination relationship are obtained from the updated cleaning parameter table.
  • the method for performing the cleaning control of each target device according to the updated cleaning parameter table is similar to the above-described cleaning control method for each target device according to the original cleaning parameter table. For details, refer to the description above.
  • an embodiment of the present invention further provides a sample analyzer for performing analysis and detection on a sample to be tested to obtain a corresponding detection result to meet the use requirement.
  • the specific kind of the sample to be tested is not limited.
  • the sample to be tested includes a solid sample or a liquid sample. It can be understood that when the liquid sample is tested, the liquid sample needs to be placed in a sample container such as a test tube, a micro cup or the like which can carry the reaction container. Further liquid samples include, but are not limited to, blood samples.
  • the sample analyzer may include a control device, a display device, a sample storage device 11, a reagent storage device 12, a sampling needle 14, a reagent needle 15, a sample incubation detecting device 13, a cleaning device 16, and an agitator 17.
  • the reagent storage device 12 is used for storing reagents, and is capable of storing various reagents required for sample detection, facilitating selection of a desired reagent, and improving the efficiency of aspirating reagents.
  • the sample incubation detecting device 13 is used for incubating the sample so that the sample and the reagent fully react, so that the sample reaches the optimal reaction condition, and the sample parameter is conveniently detected; and the sample incubation detecting device 13 can also detect the sample after the incubation is completed. To get the parameters of the sample.
  • the sampling needle is used to aspirate the sample to effect the transfer of the sample.
  • the reagent needle is used to aspirate the reagent to effect the transfer of the reagent.
  • the sampling needle and the reagent needle can also be cleaned by a cleaning agent to avoid cross-contamination and ensure the accuracy of sample detection.
  • the number of reagent needles is two, which are a first reagent needle and a second reagent needle, respectively, and the first reagent needle and the second reagent needle can respectively transfer the reagent on the reagent storage device 12 to the sample for incubation.
  • the reaction vessel of the detection device 13 is in the reaction vessel.
  • the number of sampling needles may be plural.
  • the sample storage device 11 includes a sample carrier disk that is rotatable and disk shaped.
  • the sample carrier tray can carry multiple samples.
  • a plurality of sample placement holes are formed in the sample carrier tray, and the reaction container containing the sample is placed in the sample placement hole.
  • the plurality of sample placement holes are distributed along the circumference of the sample carrier disk with the center of the sample carrier disk as a reference, and the sample carrier disk has at least two sample placement holes, which can increase the number of samples carried by the sample carrier disk and improve the sample. Detection efficiency.
  • the reagent storage device 12 includes a rotatable and disk-shaped reagent carrier disk that is capable of storing a plurality of reagents. It can be understood that the reagent carrier tray can also store the container containing the cleaning agent and the volume containing the deionized water. Or a liquid with other functions.
  • the agitator 17 is disposed on the circumferential side of the sample incubation detecting device 13.
  • the agitator 17 is used for stirring the sample and the reagent in the reaction container, so that the sample and the reagent are uniformly mixed, thereby ensuring the incubation effect of the sample and the reagent, so that the sample detection result is accurate.
  • the number of the agitators may be plural.
  • the cleaning device 16 includes a cuvette cleaning mechanism 161 for cleaning the cuvette, a sample needle cleaning mechanism 162 for cleaning the sampling needle, a reagent needle cleaning mechanism 163 for cleaning the reagent needle, and A stirring rod cleaning mechanism 164 for cleaning the agitator.
  • control device comprises a processor and a memory
  • the computer program is stored on the memory
  • the display device is configured to display a preset cleaning parameter table
  • the processor is configured to execute the method of any of the above embodiments.
  • the processor can be used to obtain current operation information of the current operation step, and historical operation information of the target device used by the current operation step; according to the historical operation information of the target device and the current operation information of the current operation step, the preset cleaning is performed.
  • an embodiment of the present invention further provides a sample analyzer 200 , which may include a first information acquiring module 210 , a second information acquiring module 220 , and a control module 230 .
  • the first information acquiring module 210 is configured to acquire current operation information of the current operation step, and historical operation information of the target device that is required to be used in the current operation step.
  • the current operational information of the current operational steps includes the target device required to perform the current operational step and the cleaning agent or the like required for the target device to perform the current operational steps.
  • the historical operation information of the target device includes historical operation steps performed by the target device before performing the current operation step, and the number of times the cleaning agent and the cleaning agent used for completing the corresponding historical operation steps, and the like.
  • the second information acquiring module 220 is configured to obtain, according to the historical operation information of the target device and the current operation information of the current operation step, the cross-contamination relationship between the historical operation steps of the target device and the current operation step from the preset cleaning parameter table. The preset cleaning operation information corresponding to the cross-contamination relationship is released.
  • the control module 230 is configured to: when the cross-contamination relationship between the historical operation step of the target device and the current operation step is not released, clean the target device according to the preset cleaning operation information, or according to historical operation information and pre-preparation of the target device Set the operation information to clean the target device.
  • the processor can find whether there is a cross-contamination relationship between the historical operation steps of the target device and the current operation step by searching the preset cleaning parameter table.
  • the processor is capable of obtaining a cross-contamination relationship between the current operation step and the historical operation step of the target device from the preset cleaning parameter table
  • the preset cleaning corresponding to the cross-contamination relationship obtained by the query may be The operation information is used to clean the target device to remove the cross-contamination relationship between the historical operation steps of the target device and the current operation steps, so as to ensure the accuracy of the current operation steps. If the processor does not obtain the cross-contamination relationship between the current operation step and the historical operation step from the preset cleaning parameter table, it can be considered that there is no cross-contamination relationship between the current operation step of the target device and the historical operation step.
  • an embodiment of the present invention further provides a computer readable storage medium, where the computer program stores a computer program, and when the computer program is executed by one or more processors, specifically executing any of the foregoing embodiments Methods.
  • the storage medium may be a magnetic disk, an optical disk, a read-only memory (ROM), or a random access memory (RAM).
  • the cleaning control method, system and sample analyzer of the sample analyzer of the present invention store the cross-contamination relationship between the historical operation steps of each target device and the current operation step in the preset cleaning parameter table and release the cross-contamination relationship Corresponding preset cleaning operation information, so that when there is a cross-contamination relationship between the historical operation step of the target device and the current operation step, and the cross-contamination is not released, the target may be compared according to the preset cleaning operation information corresponding to the cross-contamination relationship.
  • the device performs targeted cleaning to remove the cross-contamination relationship of the target device and improve the cleaning effect of the target device; and, through the above-mentioned preset cleaning operation information corresponding to the cross-contamination relationship in the preset cleaning parameter table, the target is The device is cleaned, which also reduces the amount of cleaning agent and water used by the cleaning agent and saves resources.

Landscapes

  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

一种样本分析仪的清洗控制方法,包括如下步骤:获取当前操作步骤的当前操作信息,以及当前操作步骤所需使用的目标器件的历史操作信息;根据目标器件的历史操作信息及当前操作步骤的当前操作信息,从预设的清洗参数表中获得目标器件的历史操作步骤与当前操作步骤之间的交叉污染关系及解除交叉污染关系对应的预设清洗操作信息;当目标器件的历史操作步骤与当前操作步骤之间的交叉污染关系未被解除时,则按照预设清洗操作信息对目标器件进行清洗,或者根据目标器件的历史操作信息和所述预设操作信息对目标器件进行清洗。还提供了一种样本分析仪。该样本分析仪的清洗控制方法可以避免交叉污染,提高清洗效果,且能够减少清洗剂和水的使用量,节约资源。

Description

样本分析仪的清洗控制方法及样本分析仪 技术领域
本发明涉及样本分析仪技术领域,特别是涉及一种样本分析仪的清洗控制方法及样本分析仪。
背景技术
在全自动样本分析仪中,由于采样针、搅拌器和反应容器等需要接触反应液,往往存在交叉污染的问题,因此,上述采样针、搅拌器和反应容器在使用前和使用后往往需要进行清洗,以避免交叉污染导致的分析结果不准确的问题。
传统的样本分析仪中,若当前测试存在交叉污染的风险时,往往会对测试过程中使用的所有器件进行清洗操作,如对自动样本分析仪上采样针、搅拌器和所有反应容器等器件均进行清洗操作。例如,采用同一种性质的清洗液对所有容器进行清洗,或者同时使用两种不同性质的清洗液对所有容器进行清洗。但由于交叉污染的属性差异,若只使用同一种性质的清洗液,不能适用于所有交叉污染属性所需的清洗操作,清洗效果不佳。若直接使用两种不同性质的清洗液进行清洗,则多余一种清洗液的清洗也会产生潜在的污染风险,且存在资源浪费,清洗效果不佳。
发明内容
鉴于传统的样本分析仪的清洗效果不佳的问题,本发明的目的在于提供一种样本分析仪的清洗控制方法及样本分析仪,优化各个器件的清洗效果,且节约资源。
为实现上述目的,本发明采用如下技术方案:
一种样本分析仪的清洗控制方法,所述方法包括如下步骤:
获取当前操作步骤的当前操作信息,以及所述当前操作步骤所需使用的目标器件的历史操作信息;
根据所述目标器件的历史操作信息及所述当前操作步骤的当前操作信息,从预设的清洗参数表中获得所述目标器件的历史操作步骤与所述当前操作步骤之间的交叉污染关系,及解除所述交叉污染关系对应的预设清洗操作信息;
当所述目标器件的历史操作步骤与所述当前操作步骤之间的交叉污染关系未被解除时,则按照所述预设清洗操作信息对所述目标器件进行清洗,或者根据所述目标器件的历史操作信息和所述预设操作信息对所述目标器件进行清洗。
同时,本发明还提供了一种样本分析仪,包括控制装置、显示装置、用于存储样本的样本存储装置、用于存储试剂的清洗剂存储装置、用于吸排样本或试剂的分注装置、用于样本孵育与检测的样本孵育检测装置及用于清洗的清洗装置;所述控制装置包括处理器和存储器,所述存储器上存储有计算机程序,所述显示装置用于显示预设的清洗参数表;
所述处理器用于获取当前操作步骤的当前操作信息,以及所述当前操作步骤所需使用的 目标器件的历史操作信息;
根据所述目标器件的历史操作信息及所述当前操作步骤的当前操作信息,从预设的清洗参数表中获得所述目标器件的历史操作步骤与所述当前操作步骤之间的交叉污染关系,及解除所述交叉污染关系对应的预设清洗操作信息;
当所述目标器件的历史操作步骤与所述当前操作步骤之间的交叉污染关系未被解除时,则按照所述预设清洗操作信息对所述目标器件进行清洗,或者根据所述目标器件的历史操作信息和所述预设操作信息对所述目标器件进行清洗。本发明还提供了一种样本分析仪,包括:
第一信息获取模块,用于获取当前操作步骤的当前操作信息,以及所述当前操作步骤所需使用的目标器件的历史操作信息;
第二信息获取模块,用于根据所述目标器件的历史操作信息及所述当前操作步骤的当前操作信息,从所述预设的清洗参数表中获得所述目标器件的历史操作步骤与所述当前操作步骤之间的交叉污染关系及解除所述交叉污染关系对应的预设清洗操作信息;
控制模块,用于当所述目标器件的历史操作步骤与所述当前操作步骤之间的交叉污染关系未被解除时,则按照所述预设清洗操作信息对所述目标器件进行清洗,或者根据所述目标器件的历史操作信息和所述预设操作信息对所述目标器件进行清洗。
此外,本发明提供了一种计算机可读存储介质,所述存储介质上存储有计算机程序,所述计算机程序被一个或多个处理器执行时,具体执行上述任一项所述的方法。
本发明的有益效果是:
本发明的样本分析仪的清洗控制方法及样本分析仪,通过在预设的清洗参数表中存储各个目标器件的历史操作步骤与当前操作步骤之间的交叉污染关系及解除该交叉污染关系对应的预设清洗操作信息,从而在目标器件的历史操作步骤与当前操作步骤之间存在交叉污染关系且该交叉污染未被解除时,可以根据该交叉污染关系对应的预设清洗操作信息对目标器件进行针对性的清洗,以解除目标器件存在的交叉污染关系,提高目标器件的清洗效果;并且,通过上述根据预设的清洗参数表中的该交叉污染关系对应的预设清洗操作信息对目标器件进行清洗,还可以减少清洗剂的使用量,节约资源。
附图说明
图1为本发明一实施例的样本分析仪的清洗控制方法的流程图;
图2为本发明一实施例的样本分析仪的清洗控制方法的流程图;
图3为本发明一实施例的样本分析仪的清洗控制方法的流程图;
图4为本发明一实施例的样本分析仪的清洗控制方法的流程图;
图5为本发明一实施例的样本分析仪的结构示意图;
图6为本发明一实施例的样本分析仪的结构框图。
具体实施方式
为了使本发明的技术方案更加清楚,以下结合附图,对本发明的样本分析仪的清洗控制 方法及样本分析仪作进一步详细的说明。应当理解,此处所描述的具体实施例仅用以解释本发明并不用于限定本发明。需要说明的是,在不冲突的情况下,本申请中的实施例及实施例中的特征可以相互组合。
本发明一实施例提供了一种样本分析仪的清洗控制方法,用于根据目标器件的不同污染属性,自动对目标器件进行针对性的清洗,解决目标器件的污染状况,并提高清洗效果,节约资源。其中,目标器件的污染属性可以根据目标器件使用的试剂之间是否发生化学反应进行确定。
本实施例中,为实现样本分析仪的智能化清洗,可以在样本分析仪上预先存储有清洗参数表。该预设的清洗参数表中可以记录各种试剂之间的交叉污染关系(即各种试剂是否存在化学反应),以及解除各个交叉污染关系所需的预设清洗操作信息,根据该预设清洗操作信息可以获知解除相应的交叉污染关系所需执行的清洗操作。可选地,该预设清洗操作信息可以包括解除交叉污染关系所需使用的预设试剂及预设清洗次数等信息。在该预设的清洗参数表中,每种交叉污染关系对应一个预设的清洗操作信息,即交叉污染关系与解除该交叉污染关系所需的清洗操作是一一对应的,从而可以实现对不同交叉污染关系的针对性清洗,保证测试结果的准确性,提高清洗效果并节约清洗剂。可选地,预设的清洗参数表还包括污染源和污染对象;污染源包括试剂的类型和/或组分、样本或反应生成物中的一种或多种;污染对象包括试剂的类型和/或组分、样本中的一种或多种。
具体地,如图1所示,上述方法包括如下步骤:
S100、获取当前操作步骤的当前操作信息,以及当前操作步骤所需使用的目标器件的历史操作信息;具体地,当前操作步骤的当前操作信息包括执行该当前操作步骤所需使用的目标器件以及该目标器件完成当前操作步骤所需使用的试剂等。该目标器件的历史操作信息包括该目标器件在执行当前操作步骤之前完成的历史操作步骤,以及完成对应的历史操作步骤所使用的试剂/清洗剂以及试剂/清洗剂的使用次数等等。例如,该,目标器件的历史操作信息可以为该目标器件在执行当前操作步骤之前的上一个操作步骤,以及上一个操作步骤使用的试剂/清洗剂,以及试剂/清洗剂的使用次数等等。
S200、根据目标器件的历史操作信息及当前操作步骤的当前操作信息,从预设的清洗参数表中获得目标器件的历史操作步骤与当前操作步骤之间的交叉污染关系,及解除交叉污染关系对应的预设清洗操作信息。具体地,该预设的清洗参数表中可以记录目标器件的历史操作步骤所使用的试剂/清洗剂,与目标器件的当前操作步骤所使用的试剂/清洗剂之间存在的交叉污染关系,以及解除交叉关系对应的预设清洗操作信息。进一步地该预设清洗操作信息可以包括解除交叉污染关系所需的预设清洗剂以及预设清洗次数。
S300、当目标器件的历史操作步骤与当前操作步骤之间的交叉污染关系未被解除时,则按照预设清洗操作信息对所述目标器件进行清洗,或者根据所述目标器件的历史操作信息和所述预设操作信息对所述目标器件进行清洗。具体地,处理器通过查找预设的清洗参数表,可以获知目标器件的历史操作步骤与当前操作步骤之间是否存在交叉污染关系。可选地,若处理器能够从预设的清洗参数表中获得该目标器件的当前操作步骤与历史操作步骤之间的交 叉污染关系,则可以根据该查询获得的交叉污染关系对应的预设清洗操作信息对目标器件进行清洗,以解除目标器件的历史操作步骤与当前操作步骤之间的交叉污染关系,保证当前操作步骤的结果准确。若处理器从预设的清洗参数表中未获得当前操作步骤与历史操作步骤之间的交叉污染关系,则可以认为该目标器件的当前操作步骤与历史操作步骤之间不存在交叉污染关系。
可选地,当目标器件历史操作步骤与当前操作步骤之间的交叉污染关系未被解除时,可以控制该目标器件对应的清洗装置按照预设清洗参数中的预设清洗操作信息对目标器件进行清洗。例如,目标器件的历史操作步骤为S1,当前操作步骤为S0,可以通过查询该预设的清洗参数表,目标器件的历史操作步骤S1与当前操作步骤S0之间存在交叉污染关系R1,以及解除该交叉污染关系R1所需的预设清洗操作信息为I1。则当目标器件的历史操作步骤S1与当期操作步骤S0之间的交叉污染关系R1未被解除时,可以按照该预设的清洗操作信息I1对目标器件进行清洗。若目标器件的当前操作步骤与历史操作步骤之间的交叉污染关系已经被解除时,则可以控制该目标器件执行当前操作步骤S0,或者控制该目标器件对应的清洗装置采用清水等清洗剂对目标器件清洗后,再控制该目标器件执行当前操作步骤S0。
可选地,在其他实施例中,当目标器件的历史操作步骤与当前操作步骤之间的交叉污染关系未被解除时,可以根据目标器件的历史操作信息和预设清洗操作信息对目标器件清洗。进一步地,可以根据目标器件的历史操作信息和预设清洗操作获得解除当前交叉污染关系所需的目标清洗操作信息,按照该目标清洗操作信息对目标器件进行清洗,以简化目标器件的清洗操作,具体清洗控制方法可参见下文中的描述。可选地,该历史操作信息包括目标器件的历史操作所使用的清洗剂或样本,以及使用清洗剂/样本的次数等等。
本实施例中,通过分别判断各个目标器件是否存在交叉污染,当该目标器件的交叉污染未被解除时,再对目标器件进行针对性的清洗。因此,本实施例的样本分析仪的清洗控制方法,通过只对存在交叉污染关系的目标器件进行清洗,能够简化样本分析仪的清洗操作,节省试剂或清水等资源,优化清洗效果,提高清洗效率。
可选地,上述预设的清洗参数表中的预设清洗操作信息包括预设清洗剂和预设清洗次数,其中,预设清洗剂可以包括酸性清洗剂、碱性清洗剂、其他洗液或清水中的一种或多种,其中,其他洗液是指除酸性清洗剂和碱性清洗剂之外的其他属性的试剂。例如,该其他清洗剂可以为含有表面活性剂或其他溶剂的试剂。其中,上述的酸性清洗剂、碱性清洗剂或其他洗液具体采用何种试剂,可以根据具体地交叉污染关系进行确定。进一步地,可以预先设定上述各种预设清洗剂的优先级排序,例如,各种优先级的排序可以为酸性清洗剂=碱性清洗剂>其他清洗剂>清水。该各种预设清洗及的优先级的排序可以存储于预设的清洗参数表中,或设定为程序默认的优先级排序。
该预设试剂可以根据目标器件的当前测试步骤与历史测试步骤之间的交叉关系进行预先设置,该预设试剂应当能够解除上述的交叉污染关系。可选地,预设清洗次数应当大于或等于零,该预设清洗次数可以根据目标器件的当前测试步骤与历史测试步骤之间的交叉污染关系,以及解除该交叉污染关系所使用的预设试剂的清洗效果进行预先设置。
可选地,根据预设清洗操作信息对目标器件进行清洗的步骤还包括:
选用酸性清洗剂对目标器件,进行第一预设清洗次数的清洗操作;和/或
选用碱性清洗剂对所述目标器件,进行第二预设清洗次数的清洗操作;和/或
选用其他清洗剂对所述目标器件,进行第三预设清洗次数的清洗操作;
选用清水对所述目标器件,进行第四预设清洗次数的清洗操作。
下面举例说明上述的清洗方式,其仅用于清楚的说明本实施例的清洗方式,并不用于将上述的清洗方式限定于以下的清洗方式:
例如,针对交叉污染关系R1,处理器可以从预设的清洗参数表中获知解除该交叉污染关系R1的预设清洗操作信息为,“预设清洗剂:酸性清洗剂;预设清洗次数:第一预设清洗次数”,则当目标器件的当前操作步骤与历史操作步骤之间存在未被解除的交叉污染关系R1时,处理器可以按照预设清洗操作信息,控制该目标器件对应的清洗装置选用酸性清洗剂,并对目标器件进行第一清洗次数的清洗,之后使用清水清洗。
例如,针对交叉污染关系R2,处理器可以从预设的清洗参数表中获知解除该交叉污染关系R1的预设清洗操作信息为,“预设清洗剂:碱性清洗剂;预设清洗次数:第二预设清洗次数”,则当目标器件的当前操作步骤与历史操作步骤之间存在未被解除的交叉污染关系R2时,处理器可以按照预设清洗操作信息,控制该目标器件对应的清洗装置选用碱性清洗剂,并对目标器件进行第二清洗次数的清洗,之后,使用清水清洗。
例如,针对交叉污染关系R3,处理器可以从预设的清洗参数表中获知解除该交叉污染关系R3的预设清洗操作信息可以为,“第一预设清洗次数的酸性清洗剂清洗,第三预设清洗次数的其他清洗剂清洗,第四预设清洗次数的水清洗”,则当目标器件当前操作步骤与历史操作步骤之间存在未被解除的交叉污染关系R3时,处理器可以按照预设清洗操作信息,控制该目标器件对应的清洗装置首先选用酸性清洗剂,并对目标器件进行第一清洗次数的清洗,之后,选用其他清洗剂对目标器件进行第三预设清洗次数的清洗,最后,使用清水清洗进行第四预设次数的清洗。
当然,在其他实施例中,处理器还可以按照预设清洗操作信息和目标器件的历史操作信息对目标器件进行清洗,具体可参见下文中的描述。
进一步地,当解除同一个交叉污染关系对应的预设清洗剂为多种时,还可以根据各个预设清洗剂的清洗效果对多个预设清洗剂的优先级进行排序,获得优先级排序,其中各个预设清洗剂的清洗效果根据使用量及清洗次数获得。例如,使用少量酸性清洗剂或碱性清洗剂清洗一次即可解除该交叉污染关系,而使用其他洗液需要清洗三次才能解除同一交叉污染关系,则针对该交叉污染关系,可以认为该酸性清洗剂或碱性清洗剂的优先级高于其他洗液的优先级。本实施例中,预设清洗操作信息还包括多种预设清洗剂的优先级排序,通过将同一交叉污染关系对应的多种预设清洗剂的优先级排序预先存储于预设的清洗参数表中,使得样本分析仪能够根据预设的清洗参数表及实际应用场景,灵活的选择清洗操作,进一步提高了其智能化程度,便于使用。
具体地,上述方法还可以包括如下步骤:
当目标器件的历史操作步骤与当前操作步骤之间的交叉污染关系未被解除时,则可以从预设的清洗参数表中获取一个或多个预设清洗剂的优先级排序;具体地,针对每一个交叉污染关系均可以设置解除该交叉污染关系的一个或多个预设清洗剂,并设置该一个或多个预设清洗剂的优先级排序。当解除该交叉污染关系对应的预设清洗剂有且仅有一个时,则该唯一的预设清洗剂始终具有最高的优先级。
根据预设清洗剂的优先级排序,选取优先级最高的预设清洗剂对目标器件进行清洗。本实施例中,通过选取优先级最高的预设清洗剂对目标器件进行清洗,不仅可以有效的解除交叉污染关系,减少二次污染,而且可以减少预设清洗剂的用量和/或清洗次数,从而能够减少资源浪费。
进一步地,预设清洗操作信息还可以包括是否强制使用预设清洗操作信息指定的预设清洗剂的清洗参数,例如,该清洗参数可以采用“是”或“否”的方式展示于预设的清洗参数表中。当该预设的清洗参数表中的清洗参数显示为“是”时,其可以用于表示解除该交叉污染关系需要强制使用预设清洗操作信息指定的预设清洗剂;当该预设的清洗参数表中的清洗参数显示为“否”时,其可以用于表示解除该交叉污染关系无需强制使用预设清洗操作信息指定的预设清洗剂,可采用替代清洗剂,例如,替代清洗剂可以采用其他洗液。此处仅举例说明,其具体展示方式可以根据实际情况进行确定,此处不做具体限定。
若需强制使用预设清洗剂,则当该预设清洗操作信息指定的预设清洗剂不可用时,则无法采用其他优先级较低的预设清洗剂进行替代。具体地,如图2所示,上述方法还包括如下步骤:
S400、判断目标器件历史操作步骤与当前操作步骤之间的交叉污染关系是否解除;
S600、判断预设清洗操作信息指定的预设清洗剂是否可用;可选地,可以将该预设清洗操作信息指定的的预设清洗剂是否耗尽,和/或是否失效,和/或是否污染,作为其是否可用的判断标准。例如,当该预设清洗操作信息指定的预设清洗剂已经耗尽时,则判定该预设清洗操作信息指定的预设清洗剂不可用。当该预设清洗操作信息指定的预设清洗剂未耗尽且未失效且未被污染时,则可以判定预设清洗操作信息指定的预设清洗剂可用。
S610、判断是否强制使用预设清洗操作信息指定的预设清洗剂。具体地,当处理器从预设的清洗参数表中获得的清洗参数为需要强制使用优先级最高的预设清洗剂时,则说明解除该交叉污染关系需要强制使用预设清洗操作信息指定的预设清洗剂。当处理器从预设的清洗参数表中获得的清洗参数为无需使用优先级最高的预设清洗剂时,则说明解除该交叉污染关系无需强制使用预设清洗操作信息指定的预设清洗剂,可以采用其他预设清洗剂进行替代。
若预设清洗操作信息指定的预设清洗剂不可用,且解除该交叉污染关系需要强制使用预设清洗剂时,则执行步骤S620,暂停目标器件的清洗操作,并发出报警提示信息,直至该预设清洗操作信息指定的预设清洗剂可用时,再执行该目标器件的清洗操作。同时,该样本分析仪还可以发出报警提示信息,以提醒工作人员及时补充清洗剂。
若预设清洗操作信息指定的预设清洗剂不可用,且解除该交叉污染关系无需强制使用预设清洗操作信息指定的预设清洗剂时,则执行步骤S700,按照预设的替代清洗操作对目标器 件进行清洗。该预设的替代清洗操作能够消除任意的交叉污染关系,因此,当解除该交叉污染关系无需强制使用预设清洗操作信息指定的预设清洗剂时,则可以采用该通用的替代清洗操作对目标清洗操作进行操作,以简化样本分析仪的清洗过程,节省资源并提高工作效率。例如,该替代清洗操作可以为采用其他洗液对目标器件清洗一次;或者采用酸性清洗剂对目标器件清洗两次;或者采用清水对目标器件清洗一次等等,此处不做具体限定。
当前,在其他实施例中,若无需强制使用预设清洗操作信息指定的预设清洗剂,则当该预设清洗操作信息指定的预设清洗剂不可用时,则可以采用其他的预设清洗剂进行替代。具体地,上述方法还可以包括如下步骤:
若预设清洗操作信息指定的预设清洗剂不可用,且解除该交叉污染关系无需强制使用预设清洗操作信息指定的预设清洗剂时,则根据预设的清洗参数表中的预设清洗剂的优先级排序,从多个预设清洗剂中选取除预设清洗操作信息指定的预设清洗剂之外的其他预设清洗剂,对目标器件进行预设清洗次数的清洗。
例如,解除目标器件的当前操作步骤与历史操作步骤之间的交叉污染关系的多种预设清洗剂的优先级排序为:酸性清洗剂>其他清洗剂>清水。此时,若酸性清洗剂不可用时,则判断其他清洗剂是否可用,若其他清洗剂可用,则可以选取其他清洗剂对目标器件进行清洗。若上述各种清洗剂均不可用,则暂停目标器件的清洗操作,并发出报警提示信息。
进一步地,上述方法还包括如下步骤:
当目标器件采用的实际清洗剂与预设清洗操作信息中指定的预设清洗剂不一致时,在预设的清洗参数表中标记警告信息。例如,该警告信息可以通过字符或数字等方式标识于预设的清洗参数表中。这样,处理器或用户能够获知该不一致的清洗操作,并判断该不一致的清洗操作是否会影响当前操作的结果准确性,从而起到了一定的污染风险预测及控制的作用。
下面举例说明上述的目标器件的清洗方法的具体实现过程:
Figure PCTCN2017105047-appb-000001
如上表所示,目标器件当前操作步骤与历史操作步骤之间存在未被解除的交叉污染关系R1,解除该交叉污染关系R1对应的预设清洗操作可以为使用预设清洗剂A1清洗两次。当解除该交叉污染关系R1需强制使用该预设清洗剂A1,且该预设清洗剂A1可用,此时,可以控制目标器件对应的清洗装置采样预设清洗剂A1对目标器件清洗两次。若预设清洗剂A1不可用,则停止目标器件的清洗,并报警。
若解除该交叉污染关系R1无需强制使用该预设清洗剂A1,且该预设清洗剂A1不可用时,则可以控制目标器件对应的清洗装置采用预设的替代清洗操作对目标器件进行清洗,以解除该交叉污染关系R1。同时,处理器还可以在预设清洗参数表中进行标记,以表明该目标器件的实际清洗操作并未采用指定的预设清洗剂A1。
再如,在另一个实施例中,
Figure PCTCN2017105047-appb-000002
如上表所示,目标器件的当前操作步骤与历史操作步骤之间存在未被解除的交叉污染关系R1,解除该交叉污染关系R1对应的预设清洗操作可以为使用预设清洗剂A2清洗一次或使用预设清洗剂A1清洗两次。当解除该交叉污染关系R1需强制使用优先级最高的预设清洗剂A2,且该预设清洗剂A2可用,此时,可以控制目标器件对应的清洗装置采样预设清洗剂A2对目标器件清洗一次。若预设清洗剂A2不可用,则停止目标器件的清洗,并报警。
若解除该交叉污染关系R1无需强制使用优先级最高的预设清洗剂A2,且优先级最高的预设清洗剂A2不可用时,则可以控制目标器件对应的清洗装置采用预设清洗剂A1对目标器件清洗两次。同时,处理器还可以在预设清洗参数表中进行标记,以表明该目标器件的实际清洗操作并未采用优先级最高的预设清洗剂。
作为进一步地改进,如图3所示,上述步骤S400还包括如下步骤:
获取目标器件的历史操作信息;其中,目标器件的历史操作信息可以包括该目标器件的历史操作,及历史操作所使用的清洗剂及清洗剂的使用次数等信息。可选地,该历史操作信息可以为该目标器件在当前操作步骤之前的上一操作步骤对应的操作信息,该上一操作步骤的操作信息可以作为该目标器件的历史操作信息存储于预设的历史操作表中,该历史操作表可以实时更新。当然,该历史操作信息可以为该目标器件在当前操作步骤之前的所有历史操作信息,该历史操作信息可以存储于预设的历史操作表中,该历史操作表可以实时更新。即每当目标器件执行一个操作步骤,可以更新一次该历史清洗参数表。
S410、根据目标器件的历史操作信息,获得目标器件已使用过的一种或多种预设清洗剂及采用各种预设清洗剂的已清洗次数。具体地,通过获取的目标器件的历史操作信息,可以获知该目标器件在该当前操作步骤之前吸取过哪些清洗剂以及吸取清洗剂的次数等信息,从而可以获得目标器件已使用的预设清洗剂的种类及使用各种预设清洗剂进行清洗的已清洗次数。
S420、根据目标器件已使用过的一种或多种预设清洗剂及采用各种预设清洗剂的已清洗次数,判断目标器件使用预设清洗操作信息中指定的预设清洗剂进行清洗的已清洗次数,是否小于目标器件对应的预设清洗操作信息中指定的预设清洗次数;
若目标器件使用所述预设清洗操作信息中指定的预设清洗剂进行清洗的已清洗次数,小 于目标器件对应的预设清洗操作信息中指定的预设清洗次数时,则可以执行步骤S430,判定目标器件的历史操作步骤与当前操作步骤之间的交叉污染未解除,此时需要对该目标器件进行清洗后,才可以执行当前操作步骤,以避免该目标器件的当前操作步骤与历史操作步骤之间的交叉污染关系,影响当前操作步骤的结果准确性。
若目标器件使用预设清洗操作信息中指定的预设清洗剂进行清洗的已清洗次数大于或等于目标器件对应的预设清洗操作信息中指定的预设清洗次数,则判定目标器件的历史操作步骤与所述当前操作步骤之间的交叉污染解除。此时,可以直接控制目标器件执行当前操作步骤,或首先控制目标器件的清洗装置采用清水等普通清洗清洗剂对目标器件进行清洗之后,再可控制该目标器件执行当前操作步骤。
进一步地,上述步骤S300进一步还包括:
S310、根据目标器件的历史操作信息,以及预设的清洗参数表中交叉污染关系对应的预设清洗操作信息,获得解除交叉污染关系所需的目标清洗操作信息,并按照目标清洗操作信息对目标器件进行清洗。可选地,该目标清洗操作信息可以包括解除目标器件的交叉污染关系所需的目标清洗剂,以及使用该目标清洗剂对目标器件进行清洗的目标清洗次数。其中,该目标清洗剂可以是预设清洗操作信息中指定的预设清洗剂,该目标清洗次数可以是预设清洗操作信息指定的预设清洗次数,与目标器件采用该指定的预设清洗剂进行清洗的已清洗次数之差。当目标器件采用指定的预设清洗剂进行清洗的已清洗次数为零时,则此时的目标清洗次数等于预设清洗操作信息指定的预设清洗次数。
例如,解除该目标器件的当前操作步骤与历史操作步骤之间的交叉污染关系所需的预设清洗操作信息表明,需要采用酸性清洗剂清洗两次;同时,根据目标器件的历史操作信息可以获知该目标器件已使用酸性清洗剂清洗一次。则解除当前交叉污染关系所需的目标清洗操作信息可以为,使用酸性清洗剂清洗一次。这样可以进一步简化目标器件的强化清洗操作,节省清洗剂和水的耗费量,节约资源,并且通过简化清洗操作步骤,能够提高样本分析仪的工作效率。
可选地,上述步骤S310进一步可以包括如下步骤:
根据目标器件使用预设清洗操作信息中指定的预设清洗剂进行清洗的已清洗次数,以及目标器件对应的预设清洗操作信息中指定的预设清洗次数,获得目标器件所需的目标清洗次数。其中,该目标清洗剂可以是预设清洗操作信息中指定的预设清洗剂,该目标清洗次数可以是预设清洗操作信息指定的预设清洗次数,与目标器件采用该指定的预设清洗剂进行清洗的已清洗次数之差。
采用预设的清洗参数中指定的预设清洗剂对目标器件进行目标清洗次数的清洗。例如,解除该目标器件的当前操作步骤与历史操作步骤之间的交叉污染关系所需的预设清洗操作信息表明,需要采用酸性清洗剂清洗两次;同时,根据目标器件的历史操作信息可以获知该目标器件已使用酸性清洗剂清洗一次。则解除当前交叉污染关系所需的目标清洗操作信息可以为,使用酸性清洗剂清洗一次。
进一步地,如图4所示,当目标器件的历史操作步骤与当前操作步骤之间未被解除的交 叉污染关系为多种时,上述步骤S310还可以包括如下步骤:
S311、根据预设的清洗参数表和目标器件的历史操作信息,分别获取解除各种交叉污染关系所需的目标清洗操作信息。具体地,处理器可以从预设的清洗参数表中获知该目标器件的当前操作步骤与该目标器件的哪些历史操作步骤之间存在交叉污染关系,并可以从预设的清洗参数表中获得解除各种交叉污染关系所需的预设清洗操作信息,即可以获得解除各种交叉污染关系所需的预设清洗剂及采用预设清洗剂进行清洗的预设清洗次数。之后,处理器可以根据各个交叉污染关系对应的预设清洗操作信息与目标器件的历史操作信息,获得解除各个交叉污染关系所需的目标清洗操作信息,该目标清洗操作信息的获得方法具体可参见上文中的描述。
S312、根据各种交叉污染关系所需的目标清洗操作信息判断目标器件的目标清洗操作是否能够合并简化。具体地,处理器可以根据各种交叉污染关系所需的目标清洗操作信息,判断采用同一清洗操作能否解除上述的多种交叉污染关系。
若各种交叉污染关系所需的目标清洗操作能够合并简化,即能够采用同一清洗操作解除上述的多种交叉污染关系时,则执行步骤S313,获取多个目标清洗操作信息中清洗要求最高的目标清洗操作信息,按照清洗要求最高的目标清洗操作信息对目标器件进行清洗;其中,清洗要求包括解除同一种交叉污染关系所需的目标清洗剂、目标清洗次数、解除该交叉污染关系对应的多种目标清洗剂的优先级排序以及是否强制使用预设清洗操作信息中指定的目标清洗剂。本实施例中,通过采用清洗要求最高的目标清洗操作信息对目标器件进行清洗,既可以保证该目标器件的清洗效果,还可以一次性解除多种交叉污染关系,节省清洗剂及清水的使用量,节约资源,且能够提高该样本分析仪的处理效率。当各种交叉污染关系所需的目标清洗操作不能够合并简化时,则可以执行步骤S314,分别按照各种交叉污染关系对应的目标清洗操作信息对目标器件进行清洗,直至解除所有的交叉污染关系。
进一步地,当目标器件的历史操作步骤与当前操作步骤之间的交叉污染关系解除时,则控制目标器件直接执行当前操作步骤,不执行清洗操作。当目标器件的历史操作步骤与当前操作步骤之间的交叉污染关系已经解除时,则无需插入强化清洗步骤,可以控制目标器件执行当前操作步骤。更进一步,当目标器件的历史操作步骤与当前操作步骤之间的交叉污染关系已经解除时,则可以直接执行当前操作步骤,或者控制清洗装置采用清水等普通清洗方式对目标器件进行清洗,之后控制目标器件执行当前操作步骤。
以下举例说明上述步骤的具体实现过程:
Figure PCTCN2017105047-appb-000003
如上表所示,处理器可以从预设的清洗参数表中,获知目标器件的当前操作步骤与历史操作步骤之间存在交叉污染关系R1,解除该交叉污染关系所需执行的清洗操作步骤为:使用 预设清洗剂A对目标器件清洗两次。同时,处理器可以获得该目标器件的历史操作信息,并从该历史操作信息中获知该目标器件已使用预设清洗剂A进行两次清洗,则处理器可以根据目标器件的交叉污染关系R1对应的预设清洗操作信息,以及目标器件的历史操作信息,判定目标器件的当前操作步骤与历史操作步骤之间的交叉污染关系R1已经被解除,此时可以直接执行当前操作步骤,或者清洗装置采用清水等普通清洗方式对目标器件进行清洗,之后控制目标器件执行当前操作步骤。此处仅示例性的说明上述步骤的实现过程,针对每一种交叉污染关系,均可以采用类似的方法进行判断交叉污染关系是否解除。
进一步地,当该目标器件的当前操作步骤与历史操作步骤之间存在多种交叉污染关系时,则需分别判断各种交叉污染关系是否均已被解除,只有当该目标器件的当前操作步骤与历史操作步骤之间存在多种交叉污染关系均被解除时,可以清洗装置采用清水等普通清洗方式对目标器件进行清洗,之后控制目标器件执行当前操作步骤。
可选地,上述方法还包括如下步骤:
若根据目标器件的历史操作信息及当前操作步骤的当前操作信息,从预设的清洗参数表中未获得目标器件的历史操作步骤与当前操作步骤之间的交叉污染关系时,则执行步骤S500,按照预设的普通清洗操作对目标器件进行普通清洗。具体地,若处理器从预设的清洗参数表中未获得目标器件的历史操作步骤与当前操作步骤之间的交叉污染关系时,则可以说明该目标器件的历史操作步骤与当前操作步骤之间不存在交叉污染,此时可以按照预设的普通清洗操作对目标器件进行普通清洗,之后控制目标器件执行当前操作步骤。这样,不仅可以节省预设清洗剂的使用量,节约资源,还可以避免预设清洗剂对当前操作步骤造成二次污染的问题,保证当前操作步骤的准确性。可选地,上述的普通清洗操作可以是采用清水对目标器件进行清洗的操作,当然,上述的普通清洗操作还可以是采用除上述预设清洗剂之外的其他清洗剂进行清洗的操作。
本实施例中,通过分别判断各个目标器件是否存在交叉污染,当该目标器件的交叉污染已经被解除,或其不存在交叉污染时,则可以不执行清洗操作或只执行普通清洗操作;当该目标器件的交叉污染未被解除时,再对目标器件进行针对性的清洗。因此,本实施例的样本分析仪的清洗控制方法,通过只对存在交叉污染关系的目标器件进行清洗,能够简化样本分析仪的清洗操作,节省试剂或清水等资源,优化清洗效果,提高清洗效率。
可选地,上述目标器件可以是反应容器、搅拌器、试剂针或采样针。可选地,该反应容器可以为反应杯、试管或样本玻片等等,该搅拌器可以为搅拌杆等。针对每一种目标器件,均可以根据预设的清洗参数表和该目标器件的历史操作信息,获得该目标器件的目标清洗操作信息,并按照目标清洗操作对目标器件进行清洗,其具体清洗方式可以采用上述任一实施例的清洗方法。
进一步地,上述各个目标器件的数量可以为多个,针对每一个目标器件均可以按照上述的清洗方法进行清洗。可选地,在获取当前操作步骤的当前操作信息的步骤之前,上述方法还包括如下步骤:
获取当前测试项目的测试信息,当前测试项目包括一个或多个操作步骤;
根据当前测试项目的测试信息判断当前测试项目所需的目标器件的数量;
若当前测试项目所需的反应容器的数量小于样本分析仪上可用的目标器件的数量时,则根据预设的清洗参数表对预设的第一数量的目标器件进行清洗,之后执行测试项目;其中,预设的第一数量大于或等于当前测试项目所需的目标器件的数量,预设的第一数量小于样本分析仪上可用的目标器件的数量。即在本实施例中,当前测试项目需要使用几个目标器件,则清洗几个目标器件,而不是一次性完成所有目标器件的清洗,从而减小清洗剂及水的使用量,节约资源,并且通过减少清洗步骤,提高了样本分析仪的工作效率。
例如,当该目标器件为试剂针时,则可以获取试剂针的当前分注步骤需要吸取的清洗剂。同时,处理器可以获取该试剂针的历史分注信息,从而获知该试剂针在当前分注步骤之前吸取过哪些清洗剂。具体地,当试剂针吸排清洗剂a1之后,按照测试顺序,试剂针需要继续吸排清洗剂b1。则在试剂针吸排清洗剂b1之前,可以通过查询预设的清洗参数表,获知该清洗剂a1和分注清洗剂b1之间存在交叉污染关系r1及解除该交叉污染关系r1所需的预设清洗操作信息。例如,解除该交叉污染关系r1所需的预设清洗操作信息对应的清洗操作为,使用酸性清洗剂清洗一次。之后,处理器可以通过试剂针的历史分注信息获知,在试剂针的两次吸排动作之间(吸取清洗剂a1和吸取清洗剂b1之间),试剂针未进行过吸排解除交叉污染关系r1所需酸性清洗剂的操作,则可以判定该交叉污染关系并未解除,此时可以首先使用酸性清洗剂对试剂针清洗一次,之后再控制试剂针吸排清洗剂b1。
进一步地,若此时酸性清洗剂不可用,且解除该交叉污染关系r1需强制使用该酸性清洗剂时,则暂停试剂针的清洗操作,并报警。若此时酸性清洗剂不可用,且解除该交叉污染关系r1无需强制使用酸性清洗剂时,则可以按照预设的替代清洗操作对试剂针进行清洗。
若通过查询预设的清洗参数表,获知该清洗剂a1和清洗剂b1之间不存在交叉污染关系r1,或者交叉污染关系r1已经被解除,则可以使用清水等普通清洗剂对试剂针进行清洗,之后控制试剂针吸排分注清洗剂b1。或者,该清洗剂a1和清洗剂b1之间不存在交叉污染关系,或者交叉污染关系r1已经被解除时,可以控制试剂针直接执行当前分注步骤。
更进一步地,该试剂针的数量可以为多个,针对每一个试剂针均可以按照上述的清洗方法进行清洗。针对每一个试剂针,在其执行当前分注步骤之前,必须消除该试剂针的当前分注步骤与其历史分注步骤之间的所有交叉污染关系。若存在未解除的交叉污染关系,且解除该交叉污染关系的清洗剂不可用时,则可以将当前分注步骤分配至其他已解除污染关系的试剂针。承接上例,该试剂针的数量可以为两个,为便于表述,两个试剂针可以分别记为第一试剂针和第二试剂针,其中第一试剂针上的交叉污染关系r1已经解除,第二试剂针上的交叉污染关系r1尚未被解除,则可以将当前分注步骤分配至第一试剂针。若两个试剂针上的交叉污染关系r1均未被解除,则可以暂停执行两个试剂针的清洗操作,并报警。
再如,当该目标器件为反应容器时,如该目标器件为反应杯时,则可以在向该反应杯内加注样本或清洗剂之前,可以获取当前操作步骤需要向反应杯添加的样本/清洗剂c1。同时,处理器还可以获取该反应杯的历史测试信息,该历史测试信息可以包括该反应杯在当前操作步骤之前盛放过哪些清洗剂或样本。具体地,在执行当前测试步骤之前,处理器可以根据当 前需要向反应杯内添加的样本/清洗剂c1,以及该反应杯在当前操作步骤之前接触过的清洗剂/样本d1、e1及f1,从预设的清洗参数表中获取当前需要向反应杯内添加的样本/清洗剂c1,与反应杯之前接触过的清洗剂/样本d1、e1及f1之间的交叉污染关系,以及各个交叉污染关系对应的预设清洗操作信息。例如,样本/清洗剂c1与样本/清洗剂d1之间存在交叉污染关系r2,样本/清洗剂c1与样本/清洗剂e1之间存在交叉污染关系r3,样本/清洗剂c1与样本/清洗剂f1之间不存在交叉污染。
处理器可以根据通过反应杯的历史测试信息,获得在当前操作步骤之前,是否对反应杯进行过解除上述交叉污染关系r2和r3对应的清洗操作,从而可以判断上述交叉污染关系r2和r3是否已经被解除。若根据预设的清洗参数表可以获知,解除上述交叉污染关系r2需要采用酸性清洗剂清洗两次,解除上述交叉污染关系r3需要采用酸性清洗剂清洗一次。且在当前操作步骤之前,未对反应杯进行过解除交叉污染关系r2和r3的清洗操作,则由于解除上述交叉污染关系r2和r3所需使用的预设清洗剂相同,则可以采用酸性清洗剂对反应杯清洗两次,以通过同时解除上述交叉污染关系r2和r3。
若根据预设的清洗参数表可以获知,解除上述交叉污染关系r2需要采用碱性清洗剂清洗两次,解除上述交叉污染关系r3需要采用酸性清洗剂或碱性清洗剂清洗一次,且解除该交叉污染关系r3并不强制使用优先级较高的酸性清洗剂。且在当前操作步骤之前,已经采用碱性清洗剂对反应杯进行了一次清洗操作,此时可以采用碱性清洗剂对反应杯清洗一次,以通过同时解除上述交叉污染关系r2和r3。
进一步地,在当前测试项目所需的反应容器的数量小于样本分析仪上可用的反应容器的数量时,则可以对第一数量的反应容器进行清洗,其中,第一数量小于样本分析仪上可用的反应容器的数量。相对于传统的清洗所有反应容器的清洗方式,可以十分有效的节省用于清洗的耗材(清洗剂或清水等)的使用量,降低仪器的使用成本。进一步地,针对每一个反应容器,可以根据该反应容器的当前测试步骤与历史测试步骤,从预设的清洗参数表中获得该反应容器的清洗操作信息,从而根据预设的清洗操作信息对各个反应容器进行针对性的清洗,具体可参见上文的描述。
又如,该目标器件还可以是采样针。由于采样针在吐样的时候有可能会接触到反应容器内已添加的清洗剂/样本等,因此,采样针接触过的清洗剂/样本可能与当前采样步骤需要吸取样本之间存在交叉污染,在采样针执行当前采样步骤之前需要对采样针进行清洗操作,以完全消除交叉污染关系。具体地,该采样针的清洗控制可以类似于上述试剂针的清洗控制方法,具体可参见上文中的描述。
当然,在其他实施例中,该目标器件还可以是搅拌器等,该搅拌器的数量可以为多个。其具体控制方式与上述采样针的控制方式类似,具体可参见上文中的描述。
作为进一步地改进,上述方法还包括如下步骤:
在交互显示界面上显示预设的清洗参数表;本实施例中,该预设的清洗参数表中可以通过交互显示界面展示给用户,以便用户能够直观地获知清洗操作。可选地,该交互显示界面可以显示于与样本分析仪连接的终端显示屏上,如电脑、手机等的显示屏上。当然,该交互 显示界面还可以显示于样本分析仪上的显示装置上,此处不做具体限定。
通过交互显示界面获取预设的清洗参数表的参数更新信息;具体地,用户可以对显示于交互显示界面上的预设的清洗参数表内的预设清洗操作信息及交叉污染关系等进行增减或修改。当用户对预设的清洗参数表进行修改时,处理器可以根据该修改操作获得预设的清洗参数表的参数更新信息,并对应存储该参数更新信息。这样,用户可以根据实际的测试项目调整该清洗参数表,从而可以使该样本分析仪能够适用于多种不同的测试项目,提高仪器的通用性。
根据预设的清洗参数表的参数更新信息,获得更新后的清洗参数表,在交互显示界面上展示更新后的清洗参数表;可选地,当完成预设的清洗参数表的更新之后,可以在交互显示界面上展示该更新后的清洗参数表,以便用户使用。
当接收到操作开始指令后,从更新的清洗参数表中获得目标器件的历史操作步骤与当前操作步骤之间的交叉污染关系,及交叉污染关系对应的预设清洗操作信息。具体地,根据更新的清洗参数表进行各个目标器件的清洗控制的方法,与上述根据原始的清洗参数表进行各个目标器件的清洗控制方法相似,具体可参见上文中的描述。
同时,如图5所示,本发明一实施例还提供了一种样本分析仪,该样本分析仪1用于对待测的样本进行分析检测,以得到相应的检测结果,满足使用需求。需要说明的是,待测的样本的具体种类不受限制,在一些实施例中,待测的样本包括固体样本或者液体样本。可以理解,对液体样本进行检测时,需要将液体样本置于样本容器如试管、微量杯等能够承载的反应容器中进行。进一步的液体样本包括但不限于血液样本。该样本分析仪可以包括控制装置、显示装置、样本存储装置11、试剂存储装置12、采样针14、试剂针15、样本孵育检测装置13、清洗装置16及搅拌器17。
其中,试剂存储装置12用于存储试剂,能够存储样本检测时所需要的各种试剂,方便选择所需的试剂,提高吸取试剂的效率。样本孵育检测装置13用于孵育样本,以使得样本与试剂充分反应,进而使得样本达到最佳的反应条件,方便样本参数的检测;同时样本孵育检测装置13还能对孵育完成后的样本进行检测,以得到样本的参数。采样针用于吸排样本,以实现将样本的转移。试剂针用于吸排试剂,以实现将试剂的转移。同时,采样针和试剂针还可以吸取清洗剂进行清洗,以避免交叉污染,保证样本检测的准确性。
为了提高试剂的转移速度,试剂针的数量为两个,分别为第一试剂针及第二试剂针,第一试剂针与第二试剂针能够分别将试剂存储装置12上的试剂转移到样本孵育检测装置13的反应容器中。可选地,采样针的数量也可以为多个。
可选地,样本存储装置11包括可转动且呈圆盘状的样本承载盘。样本承载盘能够承载多个样本。样本承载盘上开设多个样本放置孔,盛装样本的反应容器放置于样本放置孔中。多个样本放置孔以样本承载盘的圆心为基准沿样本承载盘的周向方向分布,样本承载盘上具有至少两圈的样本放置孔,这样能够增加样本承载盘承载样本的数量,提高样本的检测效率。
可选地,试剂存储装置12包括可转动且呈圆盘状的试剂承载盘,试剂承载盘能够存放多种试剂。可以理解的是,试剂承载盘中还可存放盛装有清洗剂的容器、盛装有去离子水的容 器或者盛装具有其他功能的液体。
可选地,搅拌器17设置于样本孵育检测装置13的周侧。搅拌器17用于对反应容器中的样本与试剂搅拌,使得样本与试剂混合均匀,进而保证样本与试剂的孵育效果,使得样本检测结果准确。进一步地,该搅拌器的数量可以多个。
可选地,清洗装置16包括用于对反应杯进行清洗的反应杯清洗机构161、用于对采样针进行清洗的样本针清洗机构162、用于对试剂针进行清洗的试剂针清洗机构163及用于对搅拌器进行清洗的搅拌杆清洗机构164。
可选地,控制装置包括处理器和存储器,存储器上存储有计算机程序,显示装置用于显示预设的清洗参数表;处理器用于执行上述任一实施例的方法。处理器可以用于获取当前操作步骤的当前操作信息,以及当前操作步骤所需使用的目标器件的历史操作信息;根据目标器件的历史操作信息及当前操作步骤的当前操作信息,从预设的清洗参数表中获得所述目标器件的历史操作步骤与当前操作步骤之间的交叉污染关系及解除交叉污染关系对应的预设清洗操作信息;当目标器件的历史操作步骤与当前操作步骤之间的交叉污染关系未被解除时,则根据预设清洗操作信息对所述目标器件进行清洗。应当清楚的是,本实施例的样本分析仪的工作原理与上述方法中各个步骤的执行过程基本一致,具体可参见上文中的描述。
在一个实施例中,如图6所示,本发明一实施例还提供了一种样本分析仪200,其可以包括第一信息获取模块210、第二信息获取模块220以及控制模块230。其中,第一信息获取模块210用于获取当前操作步骤的当前操作信息,以及当前操作步骤所需使用的目标器件的历史操作信息。具体地,当前操作步骤的当前操作信息包括执行该当前操作步骤所需使用的目标器件以及该目标器件完成当前操作步骤所需使用的清洗剂等。该目标器件的历史操作信息包括该目标器件在执行当前操作步骤之前完成的历史操作步骤,以及完成对应的历史操作步骤所使用的清洗剂及清洗剂的使用次数等等。
第二信息获取模块220用于根据目标器件的历史操作信息及当前操作步骤的当前操作信息,从预设的清洗参数表中获得目标器件的历史操作步骤与当前操作步骤之间的交叉污染关系及解除交叉污染关系对应的预设清洗操作信息。
控制模块230用于当目标器件的历史操作步骤与当前操作步骤之间的交叉污染关系未被解除时,则按照预设清洗操作信息对目标器件进行清洗,或者根据目标器件的历史操作信息和预设操作信息对目标器件进行清洗。具体地,处理器通过查找预设的清洗参数表,可以获知目标器件的历史操作步骤与当前操作步骤之间是否存在交叉污染关系。可选地,若处理器能够从预设的清洗参数表中获得该目标器件的当前操作步骤与历史操作步骤之间的交叉污染关系,则可以根据该查询获得的交叉污染关系对应的预设清洗操作信息对目标器件进行清洗,以解除目标器件的历史操作步骤与当前操作步骤之间的交叉污染关系,保证当前操作步骤的结果准确。若处理器从预设的清洗参数表中未获得当前操作步骤与历史操作步骤之间的交叉污染关系,则可以认为该目标器件的当前操作步骤与历史操作步骤之间不存在交叉污染关系。
应当清楚的是,本实施例的样本分析仪的工作原理与上述方法中各个步骤的执行过程基本一致,具体可参见上文中的描述。
本领域普通技术人员可以理解实现上述实施例方法中的全部或部分流程,是可以通过计算机程序来指令相关的硬件来完成,的程序可存储于一计算机可读取存储介质中。基于此,本发明一实施例还提供了一种计算机可读存储介质,该存储介质上存储有计算机程序,当该计算机程序被一个或多个处理器执行时,具体执行上述任一实施例中的方法。其中,的存储介质可为磁碟、光盘、只读存储记忆体(Read-Only Memory,ROM)或随机存储记忆体(Random Access Memory,RAM)等。
本发明的样本分析仪的清洗控制方法、系统及样本分析仪,通过在预设的清洗参数表中存储各个目标器件的历史操作步骤与当前操作步骤之间的交叉污染关系及解除该交叉污染关系对应的预设清洗操作信息,从而在目标器件的历史操作步骤与当前操作步骤之间存在交叉污染关系且该交叉污染未被解除时,可以根据该交叉污染关系对应的预设清洗操作信息对目标器件进行针对性的清洗,以解除目标器件存在的交叉污染关系,提高目标器件的清洗效果;并且,通过上述根据预设的清洗参数表中的该交叉污染关系对应的预设清洗操作信息对目标器件进行清洗,还可以减少清洗剂等清洗剂及水的使用量,节约资源。
以上实施例仅表达了本发明的几种实施方式,其描述较为具体和详细,但并不能因此而理解为对本发明专利范围的限制。应当指出的是,对于本领域的普通技术人员来说,在不脱离本发明构思的前提下,还可以做出若干变形和改进,这些都属于本发明的保护范围。因此,本发明专利的保护范围应以所附权利要求为准。

Claims (20)

  1. 一种样本分析仪的清洗控制方法,其特征在于,所述方法包括如下步骤:
    获取当前操作步骤的当前操作信息,以及所述当前操作步骤所需使用的目标器件的历史操作信息;
    根据所述目标器件的历史操作信息及所述当前操作步骤的当前操作信息,从预设的清洗参数表中获得所述目标器件的历史操作步骤与所述当前操作步骤之间的交叉污染关系,及解除所述交叉污染关系对应的预设清洗操作信息;
    当所述目标器件的历史操作步骤与所述当前操作步骤之间的交叉污染关系未被解除时,则按照所述预设清洗操作信息对所述目标器件进行清洗,或者根据所述目标器件的历史操作信息和所述预设操作信息对所述目标器件进行清洗。
  2. 根据权利要求1所述的方法,其特征在于,所述预设的清洗参数表中的预设清洗操作信息包括预设清洗剂和预设清洗次数,所述预设清洗剂包括酸性清洗剂、碱性清洗剂、其他清洗剂或清水中的一种或多种;根据所述预设清洗操作信息对所述目标器件进行清洗的步骤还包括:
    选用所述酸性清洗剂对所述目标器件,进行第一预设清洗次数的清洗操作;和/或
    选用所述碱性清洗剂对所述目标器件,进行第二预设清洗次数的清洗操作;和/或
    选用所述其他清洗剂对所述目标器件,进行第三预设清洗次数的清洗操作;
    选用所述清水对所述目标器件,进行第四预设清洗次数的清洗操作。
  3. 根据权利要求2所述的方法,其特征在于,当所述预设清洗剂为多种时,所述预设清洗操作信息还包括多种所述预设清洗剂的优先级顺序;根据所述预设清洗操作信息对所述目标器件进行清洗的步骤包括:
    从所述预设的清洗参数表中获取解除所述交叉污染关系对应的一个或多个所述预设清洗剂的优先级排序;
    根据所述预设清洗剂的优先级排序,选取优先级最高的所述预设清洗剂对所述目标器件进行清洗。
  4. 根据权利要求2所述的方法,其特征在于,所述预设清洗操作信息还包括是否强制使用所述预设清洗操作信息指定的预设清洗剂的清洗参数;所述方法还包括如下步骤:
    判断所述预设清洗操作信息指定的预设清洗剂是否可用;
    根据所述预设清洗操作信息中的清洗参数,判断解除所述交叉污染关系是否强制使用所述预设清洗操作信息指定的预设清洗剂;
    若所述预设清洗操作信息指定的预设清洗剂不可用,且解除所述交叉污染关系强制使用所述预设清洗操作信息指定的预设清洗剂,则暂停所述目标器件的清洗操作,并发出报警提示信息。
  5. 根据权利要求4所述的方法,其特征在于,所述方法还包括如下步骤:
    若所述预设清洗操作信息指定的预设清洗剂不可用,且解除所述交叉污染关系无需强制使用所述预设清洗操作信息指定的预设清洗剂时,则按照预设的替代清洗操作对所述目标器件进行清洗。
  6. 根据权利要求5所述的方法,其特征在于,所述方法还包括如下步骤:
    当所述目标器件采用的实际清洗剂与所述预设清洗操作信息中指定的预设清洗剂不一致时,在所述预设的清洗参数表中标记警告信息。
  7. 根据权利要求1-6任一项所述的方法,其特征在于,所述方法还包括如下步骤:
    根据所述目标器件的历史操作信息,获得所述目标器件已使用过的一种或多种预设清洗剂,以及采用各种所述预设清洗剂的已清洗次数;
    判断所述目标器件使用所述预设清洗操作信息中指定的预设清洗剂进行清洗的已清洗次数,是否小于所述目标器件对应的预设清洗操作信息中指定的预设清洗次数;
    若所述目标器件使用所述预设清洗操作信息中指定的预设清洗剂进行清洗的已清洗次数,小于所述目标器件对应的预设清洗操作信息中指定的预设清洗次数时,则判定所述目标器件的历史操作步骤与所述当前操作步骤之间的交叉污染未解除;
    若所述目标器件使用所述预设清洗操作信息中指定的预设清洗剂进行清洗的已清洗次数大于或等于所述目标器件对应的预设清洗操作信息中指定的预设清洗次数,则判定所述目标器件的历史操作步骤与所述当前操作步骤之间的交叉污染解除。
  8. 根据权利要求7所述的方法,其特征在于,当所述目标器件的历史操作步骤与所述当前操作步骤之间的交叉污染关系未解除时,根据所述目标器件的历史操作信息和所述预设操作信息对所述目标器件进行清洗的步骤还包括:
    根据所述目标器件的历史操作信息,以及所述预设的清洗参数表中所述交叉污染关系对应的预设清洗操作信息,获得解除所述交叉污染关系所需的目标清洗操作信息,并按照所述目标清洗操作信息对所述目标器件进行清洗。
  9. 根据权利要求8所述的方法,其特征在于,获得解除所述交叉污染关系所需的目标清洗操作信息,按照所述目标清洗操作信息对所述目标器件进行清洗的步骤还包括:
    根据所述目标器件使用所述预设清洗操作信息中指定的预设清洗剂进行清洗的已清洗次数,以及所述目标器件对应的预设清洗操作信息中指定的预设清洗次数,获得所述目标器件所需的目标清洗次数;
    采用所述预设的清洗参数中指定的预设清洗剂对所述目标器件进行目标清洗次数的清洗。
  10. 根据权利要求9所述的方法,其特征在于,当所述目标器件的历史操作步骤与所述当前操作步骤之间未被解除的交叉污染关系为多种时,所述方法还包括如下步骤:
    根据所述预设的清洗参数表和所述目标器件的历史操作信息,分别获取解除各种交叉污染关系所需的目标清洗操作信息;
    根据各种交叉污染关系所需的目标清洗操作信息判断所述目标器件的目标清洗操作 是否能够合并简化;
    若各种交叉污染关系所需的目标清洗操作能够合并简化,则获取多个所述目标清洗操作信息中清洗要求最高的目标清洗操作信息,按照所述清洗要求最高的目标清洗操作信息对所述目标器件进行清洗;
    其中,所述清洗要求包括解除所述交叉污染关系所需的目标清洗剂、目标清洗次数以及各种交叉污染关系对应的多种目标清洗剂的优先级排序。
  11. 根据权利要求10所述的方法,其特征在于,所述方法还包括:
    若判定各种交叉污染关系所需的目标清洗操作不能合并简化,分别按照各个所述目标清洗操作信息依次对所述目标器件进行清洗。
  12. 根据权利要求1-11任一项所述的方法,其特征在于,所述方法还包括如下步骤:
    当所述目标器件的历史操作步骤与所述当前操作步骤之间的交叉污染关系解除时,则控制所述目标器件执行所述当前操作步骤。
  13. 根据权利要求1-12任一项所述的方法,其特征在于,所述方法还包括如下步骤:
    若根据所述目标器件的历史操作信息及所述当前操作步骤的当前操作信息,从所述预设的清洗参数表中未获得所述目标器件的历史操作步骤与所述当前操作步骤之间的交叉污染关系时,则按照预设的普通清洗操作对所述目标器件进行普通清洗或不进行清洗。
  14. 根据权利要求1-13任一项所述的方法,其特征在于,所述目标器件包括反应容器、搅拌器、试剂针或采样针。
  15. 根据权利要求1-13任一项所述的方法,其特征在于,在获取当前操作步骤的当前操作信息的步骤之前,所述方法还包括如下步骤:
    获取当前测试项目的测试信息,所述当前测试项目包括一个或多个操作步骤;
    根据所述当前测试项目的测试信息判断所述当前测试项目所需的目标器件的数量;
    若所述当前测试项目所需的目标器件的数量小于所述样本分析仪上可用的目标器件的数量时,则根据所述预设的清洗参数表对预设的第一数量的目标器件进行清洗,之后执行所述测试项目;
    其中,所述预设的第一数量大于或等于所当前述测试项目所需的目标器件的数量,所述预设的第一数量小于所述样本分析仪上可用的目标器件的数量。
  16. 根据权利要求1-15任一项所述的方法,其特征在于,所述方法还包括如下步骤:
    获取所述预设的清洗参数表,并在交互界面上显示所述预设的清洗参数表;
    通过所述交互显示界面获取所述预设的清洗参数表的参数更新信息;
    根据所述预设的清洗参数表的参数更新信息,获得更新后的清洗参数表,在所述交互显示界面上展示所述更新后的清洗参数表;
    当接收到操作开始指令后,从所述更新的清洗参数表中获得所述目标器件的历史操作步骤与所述当前操作步骤之间的交叉污染关系,及所述交叉污染关系对应的预设清洗操作信息。
  17. 根据权利要求1-16任一项所述的方法,其特征在于,所述预设的清洗参数表还包括污染源和污染对象;
    所述污染源包括试剂的类型和/或组分、样本或反应生成物中的一种或多种;
    所述污染对象包括试剂的类型和/或组分、样本中的一种或多种。
  18. 一种样本分析仪,其特征在于,包括控制装置、显示装置、用于存储样本的样本存储装置、用于存储试剂的试剂存储装置、用于吸排样本或试剂的分注装置、用于样本孵育与检测的样本孵育检测装置及用于清洗的清洗装置;所述控制装置包括处理器和存储器,所述存储器上存储有计算机程序,所述显示装置用于显示预设的清洗参数表;
    所述处理器用于获取当前操作步骤的当前操作信息,以及所述当前操作步骤所需使用的目标器件的历史操作信息;
    根据所述目标器件的历史操作信息及所述当前操作步骤的当前操作信息,从预设的清洗参数表中获得所述目标器件的历史操作步骤与所述当前操作步骤之间的交叉污染关系,及解除所述交叉污染关系对应的预设清洗操作信息;
    当所述目标器件的历史操作步骤与所述当前操作步骤之间的交叉污染关系未被解除时,则按照所述预设清洗操作信息对所述目标器件进行清洗,或者根据所述目标器件的历史操作信息和所述预设操作信息对所述目标器件进行清洗。
  19. 一种样本分析仪,其特征在于,包括:
    第一信息获取模块,用于获取当前操作步骤的当前操作信息,以及所述当前操作步骤所需使用的目标器件的历史操作信息;
    第二信息获取模块,用于根据所述目标器件的历史操作信息及所述当前操作步骤的当前操作信息,从所述预设的清洗参数表中获得所述目标器件的历史操作步骤与所述当前操作步骤之间的交叉污染关系及解除所述交叉污染关系对应的预设清洗操作信息;
    控制模块,用于当所述目标器件的历史操作步骤与所述当前操作步骤之间的交叉污染关系未被解除时,则按照所述预设清洗操作信息对所述目标器件进行清洗,或者根据所述目标器件的历史操作信息和所述预设操作信息对所述目标器件进行清洗。
  20. 一种计算机可读存储介质,其特征在于,所述存储介质上存储有计算机程序,所述计算机程序被一个或多个处理器执行时,具体执行如权利要求1-17任一项所述的方法。
PCT/CN2017/105047 2017-09-30 2017-09-30 样本分析仪的清洗控制方法及样本分析仪 WO2019061503A1 (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/CN2017/105047 WO2019061503A1 (zh) 2017-09-30 2017-09-30 样本分析仪的清洗控制方法及样本分析仪
CN201780092959.4A CN110869138B (zh) 2017-09-30 2017-09-30 样本分析仪的清洗控制方法及样本分析仪

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2017/105047 WO2019061503A1 (zh) 2017-09-30 2017-09-30 样本分析仪的清洗控制方法及样本分析仪

Publications (1)

Publication Number Publication Date
WO2019061503A1 true WO2019061503A1 (zh) 2019-04-04

Family

ID=65903833

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2017/105047 WO2019061503A1 (zh) 2017-09-30 2017-09-30 样本分析仪的清洗控制方法及样本分析仪

Country Status (2)

Country Link
CN (1) CN110869138B (zh)
WO (1) WO2019061503A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113125765A (zh) * 2019-12-30 2021-07-16 深圳迈瑞生物医疗电子股份有限公司 一种样本分析设备及其吸液针的工作方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1947227A (zh) * 2004-04-23 2007-04-11 东京毅力科创株式会社 基板清洗方法、基板清洗装置、计算机程序和程序存储介质
JP2008175731A (ja) * 2007-01-19 2008-07-31 Toshiba Corp 自動分析装置及びその保守方法
US20090112515A1 (en) * 2007-10-30 2009-04-30 Nec Electronics Corporation Data processing and management equipment and method for data analysis of particles in surface structuring device or film forming device
CN102348988A (zh) * 2009-03-13 2012-02-08 贝克曼考尔特公司 分析器和用于清洗分配探针的方法
CN102430549A (zh) * 2011-12-15 2012-05-02 深圳市尚荣医疗股份有限公司 一种全自动生化分析仪的清洗装置及其清洗方法
CN104289466A (zh) * 2013-07-16 2015-01-21 成都深迈瑞医疗电子技术研究院有限公司 细胞分析仪及其清洗系统
CN204817325U (zh) * 2015-07-23 2015-12-02 四川迈克生物医疗电子有限公司 样本针清洗装置和样本分析仪

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2526759B2 (ja) * 1991-11-29 1996-08-21 株式会社島津製作所 自動化学分析装置
JP3525757B2 (ja) * 1998-09-18 2004-05-10 株式会社日立製作所 化学分析装置
CN101169450B (zh) * 2006-10-27 2012-06-27 深圳迈瑞生物医疗电子股份有限公司 全自动生化分析方法及装置
JP5170737B2 (ja) * 2007-09-20 2013-03-27 シスメックス株式会社 検体分析装置
JP5300447B2 (ja) * 2008-12-04 2013-09-25 ベックマン コールター, インコーポレイテッド 自動分析装置および自動分析装置における検体分注方法
DE102012200614A1 (de) * 2011-09-20 2013-03-21 Dürr Ecoclean GmbH Reinigungsanlage für Werkstücke mit Betriebszustands-Überwachung
US9897519B2 (en) * 2011-12-26 2018-02-20 Hitachi High-Technologies Corporation Automatic analyzer and method for washing sample-pipetting probe
WO2014098841A1 (en) * 2012-12-19 2014-06-26 Schneider Electric Buildings, Llc System and method for cross-contamination prevention
CN106199026B (zh) * 2016-03-09 2019-05-28 深圳雷杜生命科学股份有限公司 全自动化学发光免疫分析仪

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1947227A (zh) * 2004-04-23 2007-04-11 东京毅力科创株式会社 基板清洗方法、基板清洗装置、计算机程序和程序存储介质
JP2008175731A (ja) * 2007-01-19 2008-07-31 Toshiba Corp 自動分析装置及びその保守方法
US20090112515A1 (en) * 2007-10-30 2009-04-30 Nec Electronics Corporation Data processing and management equipment and method for data analysis of particles in surface structuring device or film forming device
CN102348988A (zh) * 2009-03-13 2012-02-08 贝克曼考尔特公司 分析器和用于清洗分配探针的方法
CN102430549A (zh) * 2011-12-15 2012-05-02 深圳市尚荣医疗股份有限公司 一种全自动生化分析仪的清洗装置及其清洗方法
CN104289466A (zh) * 2013-07-16 2015-01-21 成都深迈瑞医疗电子技术研究院有限公司 细胞分析仪及其清洗系统
CN204817325U (zh) * 2015-07-23 2015-12-02 四川迈克生物医疗电子有限公司 样本针清洗装置和样本分析仪

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113125765A (zh) * 2019-12-30 2021-07-16 深圳迈瑞生物医疗电子股份有限公司 一种样本分析设备及其吸液针的工作方法
CN113125765B (zh) * 2019-12-30 2024-03-12 深圳迈瑞生物医疗电子股份有限公司 一种样本分析设备及其吸液针的工作方法

Also Published As

Publication number Publication date
CN110869138B (zh) 2023-09-05
CN110869138A (zh) 2020-03-06

Similar Documents

Publication Publication Date Title
JP6208127B2 (ja) 自動分析装置
JP6742463B2 (ja) 自動分析装置およびメンテナンスの要否を推奨する方法
JP4299403B2 (ja) 自動分析装置
JP6373260B2 (ja) 自動分析装置
JP2008281454A (ja) 自動分析装置
JP2017021030A (ja) 自動分析装置で液体をピペッティングする方法
JP3659164B2 (ja) 自動分析装置
JP6660844B2 (ja) 自動分析装置及びプログラム
CN110320380B (zh) 自动分析装置和自动分析方法
JP2004028931A (ja) 自動分析システム
US11965903B2 (en) Automated analyzer and method of controlling automated analyzer
WO2019061503A1 (zh) 样本分析仪的清洗控制方法及样本分析仪
JP3343038B2 (ja) 自動検体検査測定装置における分注方法
JP2000105248A (ja) 生体サンプルの取扱い方法及び分析装置
JP5398705B2 (ja) 実験室自動化システムにおけるサンプルの評価分析の実行の順序を決定するための方法
JP2007205763A (ja) 自動分析装置、キャリーオーバーチェック方法、キャリーオーバーチェックプログラム及びキャリーオーバーチェックキット
JP2004251797A (ja) 自動分析装置
JP2011153942A (ja) 自動分析装置
US11828765B2 (en) Automatic analysis apparatus and method of controlling automatic analysis apparatus
CN113125765B (zh) 一种样本分析设备及其吸液针的工作方法
JP2018204962A (ja) 自動分析装置及びプログラム
US11175302B2 (en) Apparatus and method for automated analysis
WO2019176296A1 (ja) 自動分析装置
JP2012063237A (ja) 自動分析装置
JP2019211329A (ja) 自動分析装置

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 17927642

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC (EPO FORM 1205A DATED 14/09/2020)

122 Ep: pct application non-entry in european phase

Ref document number: 17927642

Country of ref document: EP

Kind code of ref document: A1