WO2019050239A1 - Composition comprenant un mélange eutectique d'extrait de c entella asiatica - Google Patents

Composition comprenant un mélange eutectique d'extrait de c entella asiatica Download PDF

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Publication number
WO2019050239A1
WO2019050239A1 PCT/KR2018/010253 KR2018010253W WO2019050239A1 WO 2019050239 A1 WO2019050239 A1 WO 2019050239A1 KR 2018010253 W KR2018010253 W KR 2018010253W WO 2019050239 A1 WO2019050239 A1 WO 2019050239A1
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Prior art keywords
butter
eutectic mixture
mixture
alcohol
extract
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PCT/KR2018/010253
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English (en)
Korean (ko)
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서동환
박천호
유권종
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코스맥스 주식회사
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Priority to CN201880057550.3A priority Critical patent/CN111065376B/zh
Publication of WO2019050239A1 publication Critical patent/WO2019050239A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying

Definitions

  • the present invention relates to a composition comprising a Centella asiatica extract.
  • Centella asiatica is also called centella, centipedes, or tiger herb, and is known as Titrated Extract of Cetella asiatica : TECA) has been used for various purposes in the field of medicine.
  • Centella asiatica is also called centella, centipedium or tiger herb, and Titrated Extract of Cetella asiatica (TECA) is used for various purposes in the field of medicine.
  • TECA Titrated Extract of Cetella asiatica
  • the centenarius extract contains asiaticoside, madecassic acid and asiatic acid as main ingredients, and exhibits skin wounds and chronic ulcer treatment activity.
  • Asian ticosides and acidic acid are involved in the production and secretion of collagen and are known to be effective in regenerating damaged skin and improving the elasticity of the dermis.
  • functional cosmetics as well as pharmaceuticals.
  • Centella asiatica extracts are generally of high viscosity type and are made into ointment formulations to enhance adhesion to the skin.
  • the main components of the centilla extract are poorly soluble, their solubility in purified water is very low. Therefore, in order to increase the solubility of Centella asiatica extract, it is dissolved in strong polar ethanol and added during the production.
  • the solubility of Centella asiatica extract decreases and precipitates frequently.
  • this method is limited to a specific formulation and thus it is difficult to apply it to the manufacture of various formulations.
  • a eutectic mixture of Centella asiatica extract is provided.
  • One aspect provides a eutectic mixture comprising centilla extract, butter, surfactants, higher alcohols and higher fatty acids.
  • a " eutectic mixture” means a mixture of two or more different components, or a mixture having a constant melting point, i.e., a process (eutectic solution), as if it were a solid compound composed of one component.
  • the eutectic mixture appears to be uniform on the surface as it has a constant melting point, but in reality it may be mixed with a number of finely different crystals.
  • the eutectic mixture may comprise 2 to 8%, 3 to 7%, 4 to 6%, or about 5% (w / w) of the centilla extract.
  • the centilla extract may comprise Titrated Extract of Cetella asiatica (TECA). TECA may contain about 40% of asiaticoside, about 40% of madecassic acid, and about 20% of asiatic acid.
  • the centilla extract may be obtained by diluting TECA with a suitable solvent such as water or ethanol.
  • the centilla extract may be commercially available as a raw material for a pharmaceutical composition or a cosmetic composition.
  • the Kunchuk extract can be easily prepared by an ordinary technician according to the standard of pharmaceuticals of the Food and Drug Administration and the known extract preparation method.
  • the eutectic mixture may comprise 20 to 60%, 25 to 55%, 30 to 50%, 35 to 45%, or about 40% (w / w) of the butter.
  • the butter may comprise vegetable butter.
  • the vegetable butter may comprise shea butter, cacao butter, mango seed butter, cooassa seed butter, or palm seed butter, or mixtures thereof.
  • the eutectic mixture may comprise 10 to 40%, 15 to 35%, 20 to 30%, or about 25% (w / w) of the surfactant.
  • the surfactant may comprise glyceryl stearate, phage-40 stearate, phage-100 stearate, polysorbate 60, or glyceryl stearate S, or mixtures thereof.
  • the eutectic mixture may comprise 5 to 25%, 10 to 20%, or about 15% (w / w) of the higher alcohol.
  • the higher alcohols may include cetyl alcohol, stearyl alcohol, behenyl alcohol, batyl alcohol, or mixtures thereof.
  • the eutectic mixture may comprise 5 to 25%, 10 to 20%, or about 15% (w / w) of the higher fatty acid.
  • the higher fatty acids may include stearic acid, isostearic acid, myristic acid, or palmitic acid, or mixtures thereof.
  • Another aspect provides a cosmetic composition comprising the eutectic mixture.
  • the cosmetic composition of the present invention may be used in cosmetics (skin lotion), skin softener, skin toner, astringent, lotion, milk lotion, moisturizing lotion, nutrition lotion, massage cream, nutritional cream, moisturizer cream, hand cream, foundation, essence,
  • cosmetics skin lotion
  • skin softener skin toner
  • astringent lotion
  • milk lotion moisturizing lotion
  • nutrition lotion massage cream
  • nutritional cream moisturizer cream
  • hand cream foundation
  • essence Such as a soap, a cleansing foam, a cleansing lotion, a cleansing cream, a body lotion, a body cleanser, a suspension, a gel, a powder, a paste, a mask pack or a sheet or an aerosol composition.
  • Compositions of such formulations may be prepared according to methods conventional in the art.
  • the cosmetic composition may contain, in addition to the above-described components, a preservative, a stabilizer, a surfactant, a thickening agent, a solubilizer, a moisturizer, an emollient agent, an ultraviolet absorber, an antiseptic, a bactericide, an emulsifier, an antioxidant, a pH adjuster, Or additives commonly used in the art such as,
  • a preservative a stabilizer
  • a surfactant e.g., a solubilizer
  • a moisturizer emollient agent
  • an ultraviolet absorber an antiseptic
  • a bactericide emulsifier
  • an antioxidant emulsifier
  • pH adjuster emulsifier
  • additives commonly used in the art such as,
  • the amount of the additional ingredient such as the preservative may be easily selected by a person skilled in the art within a range not to impair the purpose and effect of the present invention.
  • the amount of the additional ingredient is 0.001 to
  • Another aspect provides an external composition for skin comprising the eutectic mixture.
  • the composition for external application for skin may be prepared in any formulations conventionally produced in the art and includes, for example, emulsions, creams, lotions, packs, foundation, lotions, essences, hair cosmetics and the like.
  • the present invention relates to a skin lotion, a skin softener, a skin toner, an astringent, a lotion, a milk lotion, a moisturizing lotion, a nutrition lotion, a massage cream, a nutritive cream, a moisturizing cream, a hand cream, a foundation, Foams, cleansing lotions, cleansing creams, body lotions and body cleansers.
  • the cosmetic composition or the composition for external application for skin may be an aqueous type (O / W) formulation.
  • the water phase of the composition may comprise 1.0 to 20% (w / w) of a moisturizer, and 0.01 to 5.0% (w / w) of an increasing agent.
  • the moisturizing agent may include glycerin, 1,3-butylene glycol, propylene glycol, pentylene glycol, or a mixture thereof for the purpose of preventing freezing of the continuous phase at a low temperature and helping moisturizing effect.
  • the thickener may be selected from the group consisting of carbomer, guar gum, carrageenan, xanthan gum, carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, polyacrylate-13, polyacrylamide, sodium acrylate / sodium acrylate Hydroxyethyl methacrylate / sodium acryloyldimethyltaurate copolymer, or a mixture thereof.
  • carbomer guar gum, carrageenan, xanthan gum
  • carboxymethylcellulose hydroxyethylcellulose, hydroxypropylcellulose
  • polyacrylate-13 polyacrylamide
  • sodium acrylate / sodium acrylate Hydroxyethyl methacrylate / sodium acryloyldimethyltaurate copolymer or a mixture thereof.
  • the oily portion of the composition may comprise 1.0 to 30.0% (w / w) of emollient oil, 0.1 to 10.0% (w / w) of emulsifier, and 0.1 to 10.0% (w / w) of wax.
  • the emollient oil may include various ester oils, macadamia oil, jojoba oil, various vegetable oils including castor oil, squalane, mineral oil, isohexadecane, silicone oil or a mixture thereof.
  • the emulsifier may be selected from the group consisting of Cetyl Phosphite / Phosphite-10/1 dimethicone, Phage-10 Dimethicone, Stearase-21 and Stearase-2, Polyglyceryl-2 dipolyhydroxystearate, Polyglyceryl- Polyglyceryl-3 methylglucose distearate, glyceryl stearate, phage-40 stearate, phage-100 stearate, polysorbate 60, glyceryl stearate esglyceryl stearate, Or mixtures thereof.
  • the wax may comprise beads wax, candelilla wax, carnauba wax, multi-wax, paraffin wax, microcrystalline wax, ceresin wax or mixtures thereof.
  • composition contains Centella asiatica extract, it can be used for improving or treating skin damages such as skin moisturization, skin soothing, skin protection, wrinkle improvement, and the like.
  • a method for preparing a mixture comprising a centilla extract, butter, a surfactant, a higher alcohol and a higher fatty acid, heating the mixture at 65 to 80 ⁇ , and stirring to obtain a mixture; Cooling the mixture to 45 to 60 DEG C while stirring at 20 to 40 rpm, and further stirring at 4000 to 8000 rpm to obtain a mixture; And cooling the mixture to room temperature while stirring at 20 to 40 rpm.
  • the cooling may be carried out using a cooling bath or the like maintained at a temperature of 0 ° C to 20 ° C, and cooling may be performed until the mixture reaches a desired temperature regardless of time.
  • the cooling may be accompanied by an appropriate level of agitation of 20 to 40 rpm.
  • Stirring of the mixture after cooling may be carried out using a mixer of 4000 to 8000 rpm and may be carried out until the mixture is sufficiently mixed, such as 1 minute to 30 minutes, 2 minutes to 20 minutes, or 3 minutes to 10 minutes have.
  • Eutrophic mixtures comprising centella ash extract, butter, surfactants, higher alcohols and higher fatty acids can provide a wide variety of formulations containing it without precipitation.
  • FIG. 1A is a photograph showing the appearance of an O / W cosmetic composition containing Comparative Example 5.
  • FIG. 1A is a photograph showing the appearance of an O / W cosmetic composition containing Comparative Example 5.
  • FIG. 1C is a photograph showing the appearance of an O / W cosmetic composition comprising Example 18.
  • 2A is a microscope image showing that an O / W cosmetic composition containing Comparative Example 5 showed precipitation.
  • FIG. 2B is a microscope image showing that the O / W cosmetic composition containing Comparative Example 6 showed precipitation.
  • 2C is a microscope image showing that the O / W cosmetic composition containing Example 18 showed precipitation.
  • TECA Butylers, surfactants, higher alcohols and higher fatty acids were added to TECA to prepare eutectic compounds. Specifically, a eutectic mixture containing TECA was produced according to the following steps (a) to (c) using various butter, surfactant, higher alcohol and higher fatty acid with the composition shown in Tables 1-4 below Respectively. The composition of each component in Table 1-4 depends on the weight%.
  • Example 1 Example 2
  • Example 3 Example 4
  • Example 5 TECA 5.0 5.0 5.0 5.0 5.0 5.0 5.0 Sheer butter ⁇ 40.0 ⁇ ⁇ ⁇ ⁇ Cacao butter ⁇ ⁇ 40.0 ⁇ ⁇ ⁇ Mango seed butter ⁇ ⁇ ⁇ 40.0 ⁇ ⁇ Copoic acid seed butter ⁇ ⁇ ⁇ ⁇ 40.0 ⁇ Palm seed butter ⁇ ⁇ ⁇ ⁇ 40.0 Glyceryl stearate 10.0 10.0 10.0 10.0 10.0 10.0 10.0 10.0 10.0 FAGE -100 stearate 15.0 15.0 15.0 15.0 15.0 15.0 Cetearyl alcohol 15.0 15.0 15.0 15.0 15.0 Stearic acid 15.0 15.0 15.0 15.0 15.0 15.0 15.0 15.0 15.0 15.0
  • Example 9 TECA 5.0 5.0 5.0 5.0 5.0 5.0 Sheer butter 40.0 40.0 40.0 40.0 40.0 Glyceryl stearate ⁇ 10.0 ⁇ ⁇ ⁇ FAGE -100 stearate ⁇ 15.0 10.0 ⁇ ⁇ FAGE-40 stearate ⁇ ⁇ 15.0 10.0 Polysorbate 60 ⁇ ⁇ ⁇ 15.0 10.0 Glyceryl stearate S ⁇ ⁇ ⁇ ⁇ 15.0 Cetearyl alcohol 15.0 15.0 15.0 15.0 15.0 Stearic acid 15.0 15.0 15.0 15.0 15.0 15.0 15.0 15.0
  • Example 6-9 a composition in the form of a pale yellow opaque wax was obtained, while in Comparative Example 2, a composition in which TECA was precipitated was obtained.
  • Example 11 Example 12
  • Example 13 TECA 5.0 5.0 5.0 5.0 5.0 5.0 Sheer butter 40.0 40.0 40.0 40.0 40.0 Glyceryl stearate 10.0 10.0 10.0 10.0 10.0 FAGE -100 stearate 15.0 15.0 15.0 15.0 15.0 Cetearyl alcohol ⁇ 15.0 ⁇ ⁇ ⁇ Stearyl alcohol ⁇ ⁇ 15.0 ⁇ ⁇ Behenyl alcohol ⁇ ⁇ ⁇ 15.0 ⁇ Butyl alcohol ⁇ ⁇ ⁇ ⁇ 15.0 Stearic acid 15.0 15.0 15.0 15.0 15.0 15.0 15.0
  • Example 14 Preparation of Eutectic Mixtures by High Fatty Acid Exchange ingredient Comparative Example 4
  • Example 15 Example 16
  • Example 16 Example 17
  • TECA 5.0 5.0 5.0 5.0 5.0 5.0 5.0 Sheer butter 40.0 40.0 40.0 40.0 Glyceryl stearate 10.0 10.0 10.0 10.0 10.0 FAGE -100 stearate 15.0 15.0 15.0 15.0 Cetearyl alcohol 15.0 15.0 ⁇ ⁇ ⁇ Stearic acid ⁇ 15.0 ⁇ ⁇ ⁇ Isostearic acid 15.0 ⁇ ⁇ Myristic acid 15.0 ⁇ Palmitic acid 15.0
  • the O / W skin external application was prepared by applying the TECA eutectic mixture with the composition shown in Table 5 below.
  • the preparation method thereof is shown in (a) to (e) below.
  • FIGS. 1A, 1B, and 1C are photographs showing the appearance of an O / W cosmetic composition comprising Comparative Example 5, Comparative Example 6, and Example 18,
  • FIGS. 2A, 2B, and 2C are photographs of Comparative Example 5, 6 and Example 18 show that the O / W cosmetic composition exhibited the precipitation phenomenon.
  • Comparative Example 5 was prepared by adding a simple mixture of TECA, butter, surfactant, higher alcohol and higher fatty acid to the oil phase, and precipitation occurred in about one week and it was confirmed that TECA did not dissolve .
  • Comparative Example 6 was prepared by adding any one of Comparative Examples 1-4 to an oil phase, and precipitation of TECA was observed at 4 ° C, 25 ° C, 37 ° C and 45 ° C within 4 weeks.
  • Example 18 was prepared by adding any one of the eutectic mixtures prepared in Examples 1 to 17 to the oil phase, and observation was made that there was no precipitation at 4 DEG C, 25 DEG C, 37 DEG C and 45 DEG C for 8 weeks.

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Abstract

La présente invention concerne un mélange eutectique comprenant un extrait de Centella asiatica, du beurre, un tensioactif, un alcool d'ordre supérieur et un acide gras d'ordre supérieur. En utilisant le mélange eutectique, il est possible de fournir des compositions de diverses formulations, comprenant un extrait de Centella asiatica, sans phénomène de précipitation.
PCT/KR2018/010253 2017-09-05 2018-09-04 Composition comprenant un mélange eutectique d'extrait de c entella asiatica WO2019050239A1 (fr)

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CN201880057550.3A CN111065376B (zh) 2017-09-05 2018-09-04 包括积雪草提取物的共熔混合物的组合物

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KR1020170113348A KR102002283B1 (ko) 2017-09-05 2017-09-05 병풀 추출물의 공융 혼합물을 포함하는 조성물
KR10-2017-0113348 2017-09-05

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KR102258859B1 (ko) * 2019-08-16 2021-06-04 (주)나우코스 노화방지와 주름개선효과를 갖는 보습화장료용 병풀 발효추출물의 제조방법
KR102294985B1 (ko) * 2019-12-11 2021-08-30 코스맥스 주식회사 난용성 물질의 안정화용 화장료 조성물
CN113230191A (zh) * 2021-05-25 2021-08-10 内蒙古满佗丽人健康服务有限公司 黄油润泽滋养面膜
KR102473474B1 (ko) * 2021-12-01 2022-12-02 한국콜마주식회사 W/o/w 에멀젼 화장료 조성물 및 이의 제조방법
CN116270898A (zh) * 2023-03-16 2023-06-23 九仙尊霍山石斛股份有限公司 一种用于预防和治疗放射引起的皮肤损伤的石斛修复乳及其制备方法和应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5925364A (en) * 1994-10-07 1999-07-20 L'oreal Cosmetic or dermatological composition comprising an oil-in-water emulsion comprising oily globules with a lamellar liquid crystal coating
WO2005018530A2 (fr) * 2003-08-25 2005-03-03 Foamix Ltd. Mousse pharmaceutique de penetration
EP1280507B1 (fr) * 2000-05-04 2005-10-26 E-L Management Corp. Melanges eutectiques dans des compositions cosmetiques
KR20120029107A (ko) * 2010-09-16 2012-03-26 (주)한스킨 복합 추출물(ｈｃ-6)을 포함하는 피부 개선용 화장료 조성물
KR20160061902A (ko) * 2013-11-22 2016-06-01 마리 케이 인코포레이티드 민감성 피부를 위한 조성물들

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100379067B1 (ko) 2000-04-19 2003-04-08 동국제약 주식회사 병풀 정량 추출물을 함유한 외용제
AU783366B2 (en) * 2002-02-14 2005-10-20 Johnson & Johnson Limited, India A wound healing antiscarring topical composition of centella and ginseng
WO2010030824A1 (fr) * 2008-09-10 2010-03-18 Silipos, Inc. Compositions gélatineuses d'élastomère
CN102307576A (zh) * 2008-12-15 2012-01-04 班纳制药公司 用于增强水不溶性活性剂的释放和吸收的方法
CN106821837A (zh) * 2016-11-01 2017-06-13 田鹏新 一种含积雪草‑白芍药提取物的润肤霜及其制备方法
KR20170072177A (ko) 2017-06-14 2017-06-26 최경석 병풀로부터 분리한 아시아티코사이드, 마데카소사이드, 아시아틱산 및 마데카식산을 포함하는 음료 및 화장료 조성물 및 그 제조방법

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5925364A (en) * 1994-10-07 1999-07-20 L'oreal Cosmetic or dermatological composition comprising an oil-in-water emulsion comprising oily globules with a lamellar liquid crystal coating
EP1280507B1 (fr) * 2000-05-04 2005-10-26 E-L Management Corp. Melanges eutectiques dans des compositions cosmetiques
WO2005018530A2 (fr) * 2003-08-25 2005-03-03 Foamix Ltd. Mousse pharmaceutique de penetration
KR20120029107A (ko) * 2010-09-16 2012-03-26 (주)한스킨 복합 추출물(ｈｃ-6)을 포함하는 피부 개선용 화장료 조성물
KR20160061902A (ko) * 2013-11-22 2016-06-01 마리 케이 인코포레이티드 민감성 피부를 위한 조성물들

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