WO2018180009A1 - フラーレン含有化粧料用組成物 - Google Patents

フラーレン含有化粧料用組成物 Download PDF

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WO2018180009A1
WO2018180009A1 PCT/JP2018/005921 JP2018005921W WO2018180009A1 WO 2018180009 A1 WO2018180009 A1 WO 2018180009A1 JP 2018005921 W JP2018005921 W JP 2018005921W WO 2018180009 A1 WO2018180009 A1 WO 2018180009A1
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acid
extract
oil
polyoxyethylene
cosmetic composition
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PCT/JP2018/005921
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English (en)
French (fr)
Japanese (ja)
Inventor
啓貴 小寺
明宏 橋本
祐貴 勝間田
幸浩 大橋
雅之 伊藤
小百合 兵頭
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ビタミンＣ６０バイオリサーチ株式会社
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Priority to CN201880023441.XA priority Critical patent/CN110769800B/zh
Publication of WO2018180009A1 publication Critical patent/WO2018180009A1/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair

Definitions

  • the present invention relates to a cosmetic composition containing fullerene, and a cosmetic using the cosmetic composition.
  • fullerenes for cosmetics, for example, application as a pigment (Patent Document 1), application as an ultraviolet absorber (Patent Document 2), application as a melanin inhibitor (Patent) Document 3), application as a wrinkle inhibitor (Patent Document 4), application as a hair damage inhibitor (Patent Document 5), and the like are known.
  • the subject of this invention is providing the composition for cosmetics which can disperse fullerene easily in water.
  • Another object of the present invention is to provide a cosmetic composition with a fullerene-containing aqueous dispersion prepared using the composition having a transparent appearance and excellent dispersion stability.
  • the present inventors can easily disperse fullerenes in water by using a cosmetic composition containing the following components (A) to (E).
  • the present invention has been completed by finding that the above-mentioned problems can be solved.
  • (A) Oil agent in which 0.001 to 0.3% by weight of fullerene is dissolved (B) Nonionic surfactant (C) Polyhydric alcohol (D) Oil agent (E) Water Further, the cosmetic composition is bi-continue. It has been found that the fullerene-containing aqueous dispersion prepared by using the composition has a transparent appearance and is excellent in dispersion stability because of having a nuus structure and solves the above problems.
  • the present invention has been completed.
  • fullerene can be easily dispersed in water. Further, since the cosmetic composition has a bicontinuous structure, the resulting aqueous dispersion has a transparent appearance and its dispersion stability is very good.
  • Example 51 it is a graph which shows the relationship between the frequency
  • FIG. 51 shows the relationship between the frequency
  • the cosmetic composition of the present invention contains the following components (A) to (E) as essential components.
  • the component (A) used in the present invention means an oil agent in which fullerene is dissolved at a concentration of 0.001 to 0.3% by weight relative to the oil agent. 01 to 0.28% by weight, most preferably 0.03 to 0.25% by weight.
  • the oil and fullerene can be prepared by heating and dissolving with stirring. Alternatively, it can be prepared by a method as described in JP 2011-256095 A in order to dissolve fullerene at a higher concentration.
  • it can be prepared by first dissolving fullerene in a solvent such as toluene or cyclohexane, then adding an oil agent so that the fullerene has a predetermined concentration, and distilling off the solvent under reduced pressure.
  • a solvent such as toluene or cyclohexane
  • the fullerene used in the component (A) of the present invention is a general term for a spherical shell molecule composed of carbon atoms, and the carbon number thereof is C 60 , C 70 , C 76 , C 78 , C 82 , C 84 , C 90 and C 96 are known. Any of such fullerenes can be used in the present invention. These fullerenes may be used alone or in combination of two or more. Among these, from the viewpoint of solubility and availability of easy to oil, C 60, C 70, and, it is preferable to use a mixture thereof.
  • the oil agent used in the component (A) of the present invention is not particularly limited as long as it is an oil agent that dissolves fullerene.
  • lactone derivatives, ester oils, vegetable oils, hydrocarbon oils, and the like can be used. May be used alone or in admixture of two or more. Of these, lactone derivatives and ester oils are preferred from the viewpoint of dissolving fullerene stably and at a high concentration, and it is most preferred to use both.
  • the lactone derivative used in the component (A) includes a compound represented by the following general formula (1).
  • R represents a linear or branched saturated or unsaturated hydrocarbon group having 9 to 22 carbon atoms
  • R represents a linear or branched saturated or unsaturated hydrocarbon group having 9 to 22 carbon atoms
  • R in the general formula (1) specifically, nonyl group, decyl group, undecyl group, dodecyl group, tridecyl group, tetradecyl group, pentadecyl group, hexadecyl group, heptadecyl group, octadecyl group, nonadecyl group, Eicosyl group, heicosyl group, docosyl group, etc. are mentioned.
  • decyl group, undecyl group, dodecyl group, tridecyl group, tetradecyl group, pentadecyl group, etc. from the viewpoints of availability of raw materials and ease of synthesis.
  • Group, hexadecyl group, heptadecyl group, octadecyl group, eicosyl group and heneicosyl group are more preferable, and decyl group, dodecyl group, tetradecyl group and octadecyl group are most preferable.
  • n is preferably 1 compound.
  • lactone derivatives include ⁇ -tetradecalactone, ⁇ -hexadecalactone, ⁇ -octadecalactone, ⁇ -icosalactone, and ⁇ -docosalactone.
  • ester oil used in component (A) is more specifically described: glyceryl triethylhexanoate, glyceryl tricaprylate, glyceryl tricaprate, glyceryl tri (caprylate / caprate), glyceryl trioleate, triisostearic acid Glyceryl, trimethylolpropane triethylhexanoate, pentaerythrityl tetraethylhexanoate, 3-methyl-1,5-pentanediol dineopentanoate, 2,4-diethyl-1,5-pentanediol dineopentanoate, cetyl ethylhexanoate, ethyl Hexyldecyl hexanoate, isononyl isononanoate, isodecyl isononanoate, isotridecyl isononanoate, isodecyl
  • glyceryl triethylhexanoate glyceryl tri (caprylic acid / capric acid), cetyl ethylhexanoate, ethylhexyl palmitate, diethylhexyl sebacate are preferred, and tri (caprylic acid / capric acid) glyceryl, ethyl Most preferred is cetyl hexanoate.
  • nonionic surfactant of component (B) used in the present invention examples include polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene fatty acid ester, and polyoxyethylene alkyl ether. One or two or more selected can be used. These may be used singly or in combination of two or more.
  • polyglycerin fatty acid ester examples include monoesters, diesters, triesters, tetraesters, etc., of fatty acids having 8 to 22 carbon atoms and polyglycerin having a polymerization degree of 2 to 20.
  • polyglyceryl caprylate polyglyceryl caprate, polyglyceryl laurate, polyglyceryl myristate, polyglyceryl palmitate, polyglyceryl stearate, polyglyceryl isoleate, polyglyceryl isostearate, polyglyceryl behenate, polyglyceryl dicaprylate, diglyceryl polyglyceryl , Polyglyceryl dilaurate, polyglyceryl dimyristate, polyglyceryl dipalmitate, polyglyceryl distearate, polyglyceryl diistearate, polyglyceryl diisostearate, polyglyceryl dibehenate, polyglyceryl tricaprylate, polyglyceryl tricaprate, polyglyceryl trilaurate, polyglyceryl trilaurate Examples include polyglyceryl tinate, polyglyceryl tristearate, polyglyceryl trioleate, polyglyceryl
  • polyoxyethylene glycerin fatty acid ester examples include monoesters and diesters of glycerin polyoxyethylene adducts having an addition mole number of polyoxyethylene (EO) of 4 to 200 and fatty acids of 8 to 22 carbon atoms, Examples include triesters.
  • EO polyoxyethylene
  • caprylic acid polyoxyethylene glycerin capric acid polyoxyethylene glycerin, lauric acid polyoxyethylene glycerin, myristic acid polyoxyethylene glycerin, palmitic acid polyoxyethylene glycerin, stearic acid polyoxyethylene glycerin, olein Acid polyoxyethylene glycerin, polyisoethylene glyceryl isostearate, polyoxyethylene glycerin dicaprylate, polyoxyethylene glycerin dicaprate, polyoxyethylene glyceryl dilaurate, polyoxyethylene glycerin dimyristate, polyoxyethylene glycerine dipalmitate, Polyoxyethylene glyceryl distearate, polyoxyethylene glycerin dioleate, dii Polyoxyethylene glyceryl stearate, polyoxyethylene glyceryl tricaprylate, polyoxyethylene glyceryl tricaprate, polyoxyethylene glyceryl trilaurate,
  • polyoxyethylene sorbitan fatty acid esters include monoesters and diesters of sorbitan polyoxyethylene adducts having a polyoxyethylene (EO) addition mole number of 4 to 200 and fatty acids having 8 to 22 carbon atoms, Examples include triesters and tetraesters.
  • EO polyoxyethylene
  • polyoxyethylene sorbitan caprylate polyoxyethylene sorbitan caprate, polyoxyethylene sorbitan laurate, polyoxyethylene sorbitan myristate, polyoxyethylene sorbitan palmitate, polyoxyethylene sorbitan stearate, olein Polyoxyethylene sorbitan acid, polyoxyethylene sorbitan isostearate, polyoxyethylene sorbitan dicaprylate, polyoxyethylene sorbitan dicaprate, polyoxyethylene sorbitan dilaurate, polyoxyethylene sorbitan dimyristate, polyoxyethylene sorbitan dipalmitate, Polyoxyethylene sorbitan distearate, polyoxyethylene sorbitan dioleate, dii Polyoxyethylene sorbitan stearate, polyoxyethylene sorbitan tricaprylate, polyoxyethylene sorbitan tricaprate, polyoxyethylene sorbitan trilaurate, polyoxyethylene sorbitan trimyristate, polyoxyethylene sorbitan tripalmitate
  • polyoxyethylene fatty acid ester examples include monoesters and diesters of polyoxyethylene (EO) having an addition mole number of 4 to 200 and a fatty acid having 8 to 22 carbon atoms.
  • EO polyoxyethylene
  • preferred are polyoxyethylene caprylate, polyoxyethylene caprate, polyoxyethylene laurate, polyoxyethylene myristate, polyoxyethylene palmitate, polyoxyethylene stearate, polyoxyethylene oleate, isostearine.
  • Polyoxyethylene polyoxyethylene behenate, polyoxyethylene dicaprylate, polyoxyethylene dicaprate, polyoxyethylene dilaurate, polyoxyethylene dimyristate, polyoxyethylene dipalmitate, polyoxyethylene distearate, diolein Acid polyoxyethylene, polyisoethylene diisostearate, polyoxyethylene dibehenate, etc., polyoxyethylene laurate, polystearate Kishiechiren, oleate polyoxyethylene, and most preferably isostearic acid polyoxyethylene.
  • polyoxyethylene alkyl ether examples include polyoxyethylene having 4 to 200 added moles of polyoxyethylene (EO), an alkyl group having 8 to 22 carbon atoms and monoether.
  • the storage stability of the cosmetic composition As the nonionic surfactant of the above component (B), the storage stability of the cosmetic composition, the transparency and dispersion stability of the aqueous dispersion prepared using the cosmetic composition, From the viewpoint of improving, it is preferable to use a mixture of two or more.
  • the HLB of the nonionic surfactant to be used is not particularly limited, but the HLB is preferably 5 to 16, more preferably 7 to 14, as the whole component (B).
  • polyglycerol fatty acid ester is preferable, and polyglyceryl laurate, polyglyceryl stearate, polyglyceryl isostearate, polyglyceryl dilaurate, polyglyceryl distearate, diisostearate.
  • Polyglyceryl acid is most preferred.
  • component (C) polyhydric alcohol used in the present invention examples include glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl- 1,3-propanediol, trimethylolpropane, pentaerythritol, sorbitol, pentylene glycol, hexylene glycol, 1,2-hexanediol, caprylyl glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, Examples thereof include polypropylene glycol.
  • These polyhydric alcohols may be used alone or in combination of two or more. Of these, glycerin and 1,3-butylene glycol are preferable from the viewpoint of stability, and it is more preferable to use both of them.
  • Component (D) oil used in the present invention includes hydrocarbon oils such as dodecane, isododecane, hexadecane, isohexadecane, liquid paraffin, heavy liquid isoparaffin, light liquid isoparaffin, ⁇ -olefin oligomer, squalane, hydrogenated polyisobutene, etc.
  • oil agents may be used alone, or two or more kinds may be mixed and used, and the same oil agent as used in component (A) may be included.
  • oily components generally used in cosmetics can be added within a range not impairing the effects of the present invention.
  • a hydrocarbon oil such as liquid paraffin and squalane
  • the component (D) contains 50% by weight or more of hydrocarbon oil.
  • it is 70% by weight or more.
  • the water of the component (E) used in the present invention is not particularly limited as long as it is usually usable for cosmetics, and includes purified water, ion exchange water, distilled water, natural water, deep ocean water, hydrogen water, and the like. Can be used. Further, the pH may be adjusted with an acid, an alkali, a buffering agent, a chelating agent, or the like, or a preservative may be added.
  • the cosmetic composition of the present invention contains the above-mentioned components (A) to (E), and is prepared using the storage stability of the cosmetic composition and the cosmetic composition. From the viewpoint of improving the transparency and dispersion stability of the aqueous dispersion, it is more preferable to have a bicontinuous structure.
  • the bicontinuous structure means a state in which both the water phase and the oil phase form a continuous phase, and the oil phase or the water phase is in the medium having the water phase or the oil phase as a continuous phase. Means different from the general dispersed emulsion form. When it has a bicontinuous structure, both the water phase and the oil phase form a continuous phase.
  • the composition when adding a solution in which a water-soluble pigment is dissolved in water, and when an oil-soluble pigment is dissolved in oil, the composition is uniformly colored in the hue of the respective pigment.
  • a method can be used to confirm the bicontinuous structure. It can also be confirmed by a method combining observation with an electron microscope by a freeze-fracture replica method, observation of appearance, observation with an optical polarization microscope, measurement of electrical conductivity, and the like.
  • each component of the cosmetic composition of the present invention is such that the content of the component (A) is 1 to 20% by weight and the content of the component (B) is 15 from the viewpoint of forming a bicontinuous structure. 45% by weight, the content of component (C) is 10 to 35% by weight, the content of component (D) is 5 to 35% by weight, and the content of component (E) is 10 to 40% by weight. More preferably, the content of the component (A) is 5 to 15% by weight, the content of the component (B) is 20 to 40%, the content of the component (C) is 15 to 30% by weight, and the component (D ) Is 10 to 25% by weight, and the component (E) is 15 to 35% by weight.
  • the cosmetic composition of the present invention thus obtained can be easily added to an aqueous medium and stirred to prepare an aqueous dispersion containing fullerene.
  • a special apparatus such as a vortex mixer or a homogenizer is not necessary, and the production can be sufficiently performed with a stirring force such as a propeller or a stirrer.
  • a stirring force such as a propeller or a stirrer.
  • the fullerene-containing aqueous dispersion obtained in this way has a transparent appearance, and its dispersion stability is very good.
  • “transparency” means that the appearance of the liquid is transparent when the sample is placed in a glass bottle having a diameter of 3.5 cm and observed from the side.
  • the transmittance is 60% or more when a sample is put in a cell having a thickness of 1 cm and measured at a wavelength of 600 nm.
  • the amount of the cosmetic composition of the present invention added to the cosmetic is not particularly limited, but is preferably 0.01 to 30% by mass, more preferably 0, from the viewpoint of the appearance and stability of the resulting cosmetic. .05 to 10% by mass.
  • water and additives added to normal cosmetics as necessary such as oil bases, surfactants, alcohols, moisturizers, polymers, Thickening / gelling agent, antioxidant, antiseptic, bactericidal agent, chelating agent, pH adjuster / acid / alkali, UV absorber, whitening agent, solvent, exfoliating / dissolving agent, antipruritic agent, anti-inflammatory agent, antibacterial agent Sweat, refreshing agent, antihistamine, astringent, stimulant, hair-growth agent / blood circulation promoter, reducing agent / oxidant, polymer powder, hydroxy acid, vitamins and derivatives thereof, saccharides and derivatives thereof, organic Acids, enzymes, nucleic acids, hormones, inorganic powders, fragrances, pigments and the like may be contained to the extent that the effects of the present invention are not impaired.
  • additives added to normal cosmetics as necessary such as oil bases, surfactants, alcohols, moisturizers, polymers, Thickening / gelling agent, antioxidant, antiseptic
  • oily bases examples include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, aralkyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, ceralkyl alcohol, batyl alcohol, hexyldecanol, isostearyl alcohol, Higher alcohols such as 2-octyldodecanol and dimer diol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, Palmitooleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexene Higher fatty acids such
  • liquid paraffin mineral oil
  • heavy liquid isoparaffin heavy liquid isoparaffin
  • light liquid isoparaffin ⁇ -olefin oligomer
  • polyisobutene hydrogenated polyisobutene
  • polybutene squalane
  • olive-derived squalane squalene
  • petrolatum solid Hydrocarbons
  • paraffin candelilla wax, carnauba wax, rice wax, wax wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, fisher -Tropsch wax
  • polyethylene wax, waxes such as ethylene propylene copolymer
  • palm oil, palm oil, palm kernel oil, safflower oil olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, Macadamia nut oil, hazelnut oil, cucumber oil, rosehip oil, meadow foam oil, persic oil, tea tree
  • humectants and feel improvers examples include glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, Polyols such as trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol / propylene glycol copolymer and polymers thereof; diethylene glycol monoethyl ether (Ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether, etc.
  • Ethoxydiglycol ethylene glycol monoethyl ether
  • ethylene glycol monobutyl ether diethylene glycol dibutyl
  • (eicosanedioic acid / tetradecanedioic acid) water-soluble esters such as polyglyceryl-10, tetradecanedioic acid polyglyceryl-10, cyclohexanedicarboxylic acid bisethoxydiglycol; sugars such as sorbitol, xylitol, erythritol, mannitol, maltitol Alcohols; glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins ( ⁇ -, ⁇ -, ⁇ - Cyclodextrins and modified cyclodextrins such as maltosylation and hydroxyalkylation),
  • the surfactant include an anionic surfactant, a nonionic surfactant, a cationic surfactant, an amphoteric surfactant, and a polymer surfactant.
  • an anionic surfactant a nonionic surfactant
  • a cationic surfactant a cationic surfactant
  • an amphoteric surfactant a polymer surfactant.
  • HLB of surfactant It can use from about 1 low thing to about 20 high thing, It is also preferable to combine a low thing and a high thing of HLB.
  • preferable surfactants include fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfates such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; laureth Polyoxyethylene alkyl sulfates such as sodium sulfate and laureth sulfate triethanolamine; cocoyl methyl taurine sodium, cocoyl methyl taurine potassium, lauroyl methyl taurine sodium, myristoyl methyl taurine sodium, lauroyl methyl alanine sodium, lauroyl sarcosine sodium, lauroyl sarcosine triethanol Acyl N-methyl amino acid salts such as amine and sodium methylalanine lauroylglutamate; Cocoyl Glue Acyl amino acid salts such as sodium phosphate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl gluta
  • Polymers, thickeners and gelling agents include guar gum, locust bean gum, queens seed, carrageenan, galactan, arabic gum, tara gum, tamarind, far selelain, karaya gum, troarooi, cara gum, tragacanth gum, pectin, pectic acid and sodium Salt such as salt, salt such as alginic acid and sodium salt, mannan; starch such as rice, corn, potato, wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salt, xanthan gum, pullulan, gellan gum, chitin , Chitosan, agar, gypsophila extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypro Cellulose, carboxymethylcellulose and its sodium salts, methylhydroxypropylcellulose,
  • Solvents and propellants include ethanol, 2-propanol (isopropyl alcohol), butanol, isobutyl alcohol and other lower alcohols; propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, isopentyl diol and other glycols Diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether Glycol ethers such as ethylene glycol monoethyl ether Glycol ether esters such as diacetate, diethylene glycol monoethyl ether acetate, propylene glycol monoethyl ether acetate; glycol esters such as dieth
  • Antioxidants include tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or derivatives thereof; erythorbic acid and derivatives thereof; Preferred are sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, cysteine hydrochloride As mentioned.
  • Preferred examples of the reducing agent include thioglycolic acid, cysteine, cysteamine and the like.
  • Preferred examples of the oxidizing agent include aqueous hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate.
  • Antibacterial agents or antiseptics include parabens (hydroxybenzoic acid esters) such as methylparaben, ethylparaben, propylparaben, butylparaben; phenoxyethanol; 1,2-pentanediol, 1,2-hexanediol, 1,2-octane 1,2-alkanediols such as diols; alkyl glyceryl ethers such as 2-ethylhexyl glyceryl ether (ethylhexyl glycerin); salicylic acid; sodium benzoate; isothiazolinone derivatives such as methyl chloroisothiazolinone and methylisothiazolinone; Dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides, quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, chloride Sar
  • chelating agents include edetate (ethylenediaminetetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytic acid; Phosphonic acid and its sodium salt; sodium oxalate; polypolyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine Gluconic acid, ascorbic acid, succinic acid, and tartaric acid are preferable.
  • edetate ethylenediaminetetraacetate
  • HEDTA3Na EDTA3Na
  • EDTA4Na hydroxyethylethylenediaminetriacetate
  • pentetate diethylenetriaminepent
  • pH adjusters / acids / alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanol Amine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, hydroxylated Sodium, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate are preferable.
  • powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, silica Barium acid, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorine apatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, Metal soap (for example, zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, bengara, yellow iron oxide, black iron oxide, ultramarine, bitumen, carbon black, titanium oxide, fine particles and super Titanium oxide, zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fumed silica (ultraf
  • Inorganic salts include sodium chloride-containing salts such as salt, common salt, rock salt, sea salt, natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, Aluminum sulfate / potassium sulfate (alum), aluminum sulfate / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na, 2Na and 3Na phosphates, phosphoric acid Potassium, calcium phosphates and magnesium phosphates are preferred.
  • sodium chloride-containing salts such as salt, common salt, rock salt, sea salt, natural salt
  • potassium chloride aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chlor
  • ultraviolet absorbers examples include paraaminobenzoic acid, paraaminobenzoic acid monoglycerin ester, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxyparaaminobenzoic acid ethyl ester, and N, N-dimethylparaaminobenzoic acid ethyl ester.
  • Benzoic acid ultraviolet absorbers such as esters, N, N-dimethylparaaminobenzoic acid butyl ester, N, N-dimethylparaaminobenzoic acid ethyl ester; Anthranilic acid ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; Salicylic acid And salicylic acid systems such as sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate External line absorbent: octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropy
  • Benzophenone series External line absorber 3- (4′-methylbenzylidene) -d, l-camphor, 3-benzylidene-d, l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2′-hydroxy-5- 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole; 2- (2′-hydroxy-5′-methylphenylbenzotriazole; dibenzalazine; dianisoylmethane; 5- (3 , 3-dimethyl-2-norbornylidene) -3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octyl triazone; urocanic acid derivatives such as urocanic acid and ethyl urocanate; 2- (2′-hydroxy-5′-methylphenyl) benzotriazole, 1- 3,4-dimethoxyphenyl)
  • hydantoin derivatives phenylbenzimidazolazosulfonic acid, terephthalylidene dicamphor Preferred are sulfonic acid, drometrizole trisiloxane, methyl anthranilate, rutin and derivatives thereof, oryzanol and derivatives thereof.
  • Vitamins and their derivatives include vitamin A such as retinol, retinol acetate, retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, Flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid such as nicotinic acid amide / benzyl nicotinate, vitamin B group such as choline; vitamin C such as ascorbic acid and its sodium salt; vitamin D; ⁇ , Vitamin E such as ⁇ , ⁇ , and ⁇ -tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphates such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt, Ascorbic acid fatty acid esters
  • Anti-inflammatory and anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; peach leaf extract A plant extract such as a koji leaf extract is preferable.
  • Plant growth and tinctures such as assembly extract, red pepper tincture, ginger tincture, ginger extract, cantalis tincture; capsaicin, nonyl acid valenylamide, gingeron, ictamol, tannic acid Borneol, cyclandrate, cinnarizine, trazoline, acetylcholine, verapamil, cephalanthin, ⁇ -oryzanol, cephalanthin, vitamin E and derivatives such as tocopherol / nicotinic acid tocopherol, ⁇ -oryzanol, nicotinic acid and nicotinamide / benzyl nicotinate Derivatives such as ester, inositol hexanicotinate, nicotine alcohol, allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, Preferable examples include flavonol derivatives,
  • Preferred hormones include estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone and the like.
  • Other remedies such as anti-wrinkle agents, anti-aging agents, squeeze agents, cooling sensations, warming sensation agents, wound healing promoters, irritation relievers, analgesics, cell activators include retinols, retinoic acids, retinoin Acid tocopheryl; derivatives such as lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and glycosides / esterified products thereof, ⁇ - or such as hydroxycapric acid, long chain ⁇ -hydroxy fatty acid, long chain ⁇ -hydroxy fatty acid cholesteryl ⁇ -hydroxy acids and derivatives thereof; ⁇ -aminobutyric acid, ⁇ -amino- ⁇ -hydroxybutyric acid; carnitine; carnosine; creatine; ceramides, sphingosines; caffeine, x
  • Antioxidant / active oxygen scavengers include catechins; flavones such as quercetin; isoflavones; gallic acid and ester sugar derivatives; polyphenols such as tannin, sesamin, protoanthocyanidin, chlorogenic acid, apple polyphenol; rutin and glycosides, etc.
  • Preferred examples include capsaicin, vanillin and the like and derivatives; insect repellents such as diethyltoluamide; and complexes of physiologically active substances and cyclodextrins.
  • antipruritic agents include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor and the like.
  • exfoliating / dissolving agent include salicylic acid, sulfur, resorcin, selenium sulfide, pyridoxine and the like.
  • antiperspirant include chlorohydroxyaluminum, aluminum chloride, zinc oxide, and zinc paraphenol sulfonate.
  • Examples of the refreshing agent include menthol and methyl salicylate.
  • the astringent include citric acid, tartaric acid, lactic acid, aluminum sulfate / potassium sulfate, and tannic acid.
  • enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease, and the like.
  • Preferred nucleic acids include ribonucleic acid and salts thereof, deoxyribonucleic acid and salts thereof, and adenosine triphosphate disodium.
  • Orange No. 204 Yellow No. 205, Yellow No. 401, Blue No. 404, Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205
  • Organic pigments such as zirconium, barium or aluminum lake such as yellow No. 4, yellow No. 5, yellow No. 202, yellow No. 203, green No. 3 and blue No.
  • anthraquinones such as astaxanthin and alizarin
  • Natural pigments and dyes such as naphthoquinones such as cumin, cochineal, shikonin, bixin, flavones, betacyanidine, henna, hemoglobin, lycopene, riboflavin, rutin; p-phenylenediamine, toluene-2,5-diamine, o-, Oxidative dye intermediates and couplers such as m-, or p-aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcin, 1-naphthol, 2,6-diaminopyridine and their salts; indoline, etc.
  • An auto-oxidizing dye such as m
  • preferable water examples include normal water, purified water, hard water, soft water, natural water, deep sea water, electrolytic alkaline ionized water, electrolytic acidic ionized water, ionic water, and cluster water.
  • cosmetic ingredient standards cosmetic ingredient-specific formulation standards, Japan Cosmetic Industry Association ingredient name list, INCI dictionary (The International Cosmetic Ingredient Dictionary and Handbook), Quasi-drug ingredient standards, Japanese Pharmacopoeia, Pharmaceutical Additives Ingredients listed in standards, official food additives, etc., and Japanese and foreign patent publications and patent publications (including publications and republications) in which the international patent classification IPC belongs to the classification of A61K7 and A61K8 It is possible to contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., such as the ingredients described, in known combinations, blending ratios and blending amounts.
  • the types of cosmetics of the present invention include hair cosmetics, basic cosmetics, makeup cosmetics, aromatic cosmetics, body cosmetics, skin external preparations such as ointments, and the like. From the viewpoint of exerting the effects of the present invention, it can be preferably used particularly for hair cosmetics and basic cosmetics.
  • the cosmetic of the present invention can be produced according to a usual method.
  • hair cosmetics include oil shampoos, cream shampoos, conditioning shampoos, dandruff shampoos, hair color shampoos, shampoos with integrated rinses, rinses, treatments, Conditioners such as hair packs, hair mists, hair foams, hair mousses, hair sprays, hair waxes, hair gels, hair creams, water greases, set lotions, pomades, tics, etc .; color lotions, hair tonics, hair liquids, hair blows, branches Hair coat, hair oil, permanent wave agent, straight permanent agent, oxidative hair dye, hair bleach, hair color pretreatment, hair color after treatment, permanent pretreat Cement, permanent after-treatments, hair manicure, and as hair growth agents are preferred.
  • Basic cosmetics include soft lotion, astringent lotion, cleansing lotion, multi-layer lotion, etc .; emollient lotion, moisture lotion, milky lotion, nourishing lotion, nourishing milk, skin moisture, moisturizer -Emulsions such as emulsion, massage lotion, cleansing lotion, protect emulsion, sun protect, sun protector, UV care milk, sunscreen, makeup lotion, horny smoother, elbow lotion, hand lotion, body lotion; emollient cream, nutritional cream, Nourishing cream, burnishing cream, moisture cream, night cream, massage cream, cleansing cream, makeup cream, basque Cream, pre-makeup cream, sunscreen cream, suntan cream, hair removal cream, deodorant cream, shaving cream, keratin softening cream, etc .; gel such as moisture gel; essence such as moisturizing essence, whitening essence, UV protection essence Liposome cosmetics such as liposomal serum and liposome lotion; Peel-off pack, powder pack, washing pack, oil pack, cleansing mask and other packs and masks; cleansing foam, cleansing cream, cleansing milk
  • white powder, dusting powder, foundations, lipsticks, lip gloss, blusher, eyeliner, mascara, eye shadow, eyebrow, eyebrow, nail enamel, enamel remover, and nail treatment are preferable.
  • perfumes perfumes, perfume, eau de perfume, eau de toilette, eau de cologne, perfumes, fragrance powders, perfume soaps, body lotions and bath oils are preferred as the aromatic cosmetics.
  • Body cosmetics include body shampoos and other body cleansers, deodorant lotions, deodorant powders, deodorant sprays, deodorant sticks and other deodorant cosmetics, depigmenting agents, depilation / hair removal agents, bathing agents, insect repellents, etc. A repeller is preferred.
  • a skin external preparation it can be used in dosage forms such as an ointment, a patch, a lotion, a liniment, and a liquid coating agent. It can also be used as an oral cosmetic such as toothpaste and mouthwash.
  • emulsification such as oil-in-water (O / W) type, water-in-oil (W / O) type, W / O / W type, O / W / O type, etc.
  • Type cosmetics oily cosmetics, solid cosmetics, liquid cosmetics, paste cosmetics, stick cosmetics, volatile oil cosmetics, powder cosmetics, jelly cosmetics, gel cosmetics, pastes
  • Preferred examples include cosmetics, emulsified polymer cosmetics, sheet cosmetics, mist cosmetics, and spray cosmetics.
  • the cosmetic compositions of Examples 1 to 6 and Reference Examples 1 to 6 were able to disperse fullerene easily.
  • the cosmetic compositions of Examples 1 to 6 which had formed a bicontinuous structure were transparent in appearance and excellent in storage stability.
  • the cosmetic compositions of Reference Examples 1 to 6 that did not form a bicontinuous structure had a turbid appearance from the beginning, resulting in poor storage stability.
  • Fullerene-containing aqueous dispersions having the compositions shown in Tables 4 and 5 were prepared using the cosmetic compositions of Examples 1 to 6 and Reference Examples 1 to 6. The preparation was performed by adding 49 g of water in which methylparaben was dissolved in a 100 mL beaker, slowly adding 1 g of each cosmetic composition while stirring with a stirrer (600 rpm), and stirring at room temperature for 5 minutes. The resulting aqueous dispersion was evaluated for initial dispersibility, transparency / transmittance, and dispersion stability by the following methods, and the results are shown in Tables 4 and 5 below.
  • ⁇ Initial dispersibility of aqueous dispersion> About the obtained aqueous dispersion, the dispersion state immediately after preparation was observed visually, and the initial dispersibility was evaluated according to the following evaluation criteria. ⁇ ⁇ ⁇ ⁇ Uniformly dispersed ⁇ ⁇ ⁇ ⁇ Not uniformly dispersed ⁇ Transparency and transmittance of aqueous dispersion> The obtained aqueous dispersion was put in a glass bottle having a diameter of 3.5 cm, the appearance was visually observed from the side, and the transparency was evaluated according to the following evaluation criteria. Further, the transmittance of the aqueous dispersion was measured using a spectrophotometer (cell thickness: 1 cm, wavelength: 600 nm). ⁇ ...
  • the aqueous dispersion prepared using the cosmetic composition of the present invention (forming a bicontinuous structure) can easily disperse fullerenes in water, and has initial dispersibility. It was very excellent in transparency and dispersion stability.
  • the aqueous dispersion prepared using the cosmetic composition of Reference Example (with no bicontinuous structure formed), there is a tendency that fullerene can be dispersed in water, Even though it could be dispersed, the transparency and dispersion stability were insufficient.
  • the following cosmetics were produced using the cosmetic composition of the present invention. All of the resulting cosmetics can contain fullerenes easily and stably, skin cosmetics have excellent moisturizing properties, improve pore spreading, hair cosmetics improve hair damage, and give firmness. It was something to do.
  • Cetearyl alcohol 3.0
  • PPG-1 / PEG-1 stearamine 0.8 Behenamidopropyldimethylamine 1.0 Cetrimonium chloride (25%) 5.3
  • Ethylhexyl palmitate 1.0 Neosolute-DE (Nippon Seika) 1.0 Dimethicone (1 million cs) 1.0 Dimethicone (100cs) 3.0
  • Amodimethicone 1.0 Neopentyl glycol diheptanoate
  • Cocamidopropyl betaine (30%) 8.0 Laureth sulfate Na (27%) 10.0 Cocoamphoacetate Na (30%) 5.0
  • Cocamidomethyl MEA 1.0 Distearate glycol 0.5 DPG 1.3 Cocoylthreonine Na 1.0 Dilauroyl glutamate lysine Na 0.05 PPG-70 glyceryl 0.7 PEG-10 Dimethicone 1.0 Cocoyl Arginine E
  • Lauroyl sarcosine TEA 3.0 Cocoa glutamic acid TEA (30%) 8.0 Laureth sulfate Na (27%) 10.0 Palm nuclear fatty acid amidopropyl betaine (30%) 5.0
  • Cocamidomethyl MEA 1.0 Distearate glycol 0.5 Palm oil fatty acid PEG-7 glyceryl 0.3 Ascorbyl dipalmitate 0.2 Lauric acid PEG-2 1.3 Cocoyl Arginine Ethyl PCA 0.1 Phenoxy
  • Example 28 Hair treatment component without washing away ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
  • part E part D was heated to about 80 ° C. and dissolved. While stirring D part to E part, it was gradually added and mixed uniformly, and then rapidly cooled (part F). C part was added to F part which became about 40 ° C. to make it uniform.
  • part E was heated to about 80 ° C. to make it uniform. While stirring D part to E part, it was gradually added and mixed uniformly, and then rapidly cooled (part F). C part was added to F part which became about 40 ° C. to make it uniform.
  • Example 34 Hair oil component Amount (% by weight) ------------------------------------------------------ Cosmetic composition of Example 1 0.2 Elcalactone DES (Nippon Seika) 2.0 Neosolute-MP (Nippon Seika) 10.0 Neosolute-EHS (Nippon Seika) 10.0 Neosolute-MCT (Nippon Seika) 20.0 PPG-3 caprylyl ether 2.0 Tocopherol 0.1 Propylparaben 0.05 Carnauba wax 0.1 Isododecane in a total amount of 100 -------------------------------------- (Preparation method) All ingredients were dissolved by heating and mixed.
  • Example 36 Whitening lotion component Blending amount (% by weight) --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- (Preparation method) Part A was mixed and slowly added to Part B with stirring at about 50 ° C. to prepare a dispersion. Furthermore, C part and D part mixed beforehand were added, and it was set as the uniform liquid.
  • Example 38 Moisturizing lotion component Blending amount (% by weight) --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- A Cosmetic composition of Example 1 2.0 Diglycerin 3.0 Astaxanthin 0.01 Ubiquinone 0.05 Part B purified water 20.0 Part C Neosolue-AquaS (Nippon Seika) 1.0 PEG / PPG / polybutylene glycol-8 / 5/3 glycerol 0.5 Glucosylceramide 0.5 Glucosyl rutin 0.01 Polyquaternium-51 0.5 Acetyl hexapeptide-8 0.001 Hydrolyzed collagen 0.05 Carbomer 0.05 Arginine 0.05 Phenoxyethanol 0.2 Methylparaben 0.15 Purified water Total amount to be 100 ---------------------------------------------------
  • Part C was mixed, stirred well, homogenized, and heated to about 70 ° C.
  • Part B was stirred with a propeller to prepare a dispersion.
  • C part was added to A part, it stirred using the homomixer at about 70 degreeC, it cooled to about 40 degreeC, and the liquid mixture of B part was added.
  • Example 41 Moisturizing emulsion component Blending amount (% by weight) -------------------------------------------------------------------------------------------------------------------------------------------- A Glycerin 3.0 Diglycerin 1.0 BG 7.0 Phytocompo-PP (Nippon Seika) 1.0 Hydrogenated lysolecithin (main refinement) 0.1 Part B IOTG (Nippon Seika) 3.0 LUSPLAN SR-DM4 (Nippon Seika) 0.5 Dimethicone (100CS) 5.0 Hydrogenated polyisobutene 3.5 Cetostearyl alcohol 1.0 Aralkyl alcohol 0.1 Jojoba alcohol 3.0 Kimyl alcohol 0.3 Serakil alcohol 0.1 Hexyldecanol 0.5 Part C Cosmetic composition of Example 1 2.0 Purified water 20.0 Part D (hydroxyethyl acrylate / acryloyl dimethyltaurine Na) copolymer
  • Part C was mixed with a propeller (room temperature) to prepare a dispersion.
  • Part D was mixed and stirred to give a viscous liquid.
  • part E was added and emulsified.
  • C and D parts were added, and the mixture was stirred and cooled to about 40 ° C.
  • Part C was mixed and stirred to give a viscous liquid. After adding part B while stirring part A with a homomixer, part D was added and emulsified. At about 50 ° C., part C was added, and the mixture was stirred and cooled to about 40 ° C.
  • Part C was mixed and stirred to give a viscous liquid.
  • Part D was mixed by propeller stirring to obtain a dispersion.
  • part E was added and emulsified.
  • D part and F part were added and stirred to cool to about 40 ° C.
  • Part B was mixed and stirred to give a viscous liquid.
  • Part C was mixed, heated to about 70 ° C., and dispersed uniformly.
  • Part D was mixed and heated to about 70 ° C. and dissolved uniformly.
  • a part A was added to part C while stirring with a homogenizer, and then part D was added to emulsify. At about 50 ° C., part B was added and stirred to dissolve uniformly.
  • Part C was heated to about 70 ° C. and dispersed.
  • Part D was thoroughly stirred with a propeller to prepare a dispersion. While stirring with a homomixer at about 70 ° C., part A was gradually added to part C and mixed uniformly after emulsification, cooled to about 40 ° C., and parts B and D were added and mixed uniformly.
  • Part B was heated to about 80 ° C. and dissolved uniformly. Part C was stirred well to prepare a dispersion. While part A was stirred with a homodisper, part B was added and dispersed (part E). Further, D part was added to E part with stirring. Stir and cool to about 40 ° C.
  • Example 50 Hairist component Blending amount (% by weight) --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- (Preparation method) Each of A and B parts was weighed and mixed uniformly, and then the two agents were mixed to make uniform. Furthermore, C part which was uniformly mixed was added to obtain a liquid that separated into two phases.
  • Plandool-H Dimer linoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl)
  • Plandool-S Dimer linoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl) * Plandool-G: Dimer dilinoleic acid dimer dilinoleyl bis (behenyl / isostearyl / phytosteryl)
  • Plandool-DP Bisdiglyceryl polyacyl adipate-2
  • Plandool-ISS Phytosteryl isostearate
  • Plandol-SUN Sunflower seed oil fatty acid phytosteryl
  • Plandool-MAS Macadamia nut oil fatty acid phytosteryl ⁇ Plandoooool-MAS: Macadamia nut oil fatty acid phytosteryl ⁇ Pland
  • Example 51 About the composition for cosmetics of Example 1, the fading suppression effect of hair was confirmed.
  • Human hair Gray hair (Buelux Co., Ltd.)
  • Dye-related Wellabreach cream, Cholestone Perfect 14/45, Welloxon Perfect (P & G) -Formulation prepared from the cosmetic composition of Example 1 excluding fullerene-Formulation prepared from the cosmetic composition of Example 1 (Preparation of formulation)
  • Preparation of Formulation 1 of Example 1> 0.5 g of the cosmetic composition of Example 1 was dissolved in 49.5 g of water to obtain Formulation 1.
  • Example 1 has been shown to prevent hair color fading compared to the formulation 1 to which the formulation 1 is not applied.
  • the effect of suppressing discoloration after 10 damage treatments was remarkable as compared with Formulation 2 excluding no treatment and fullerene.
  • Example 52 It is known that when hair is damaged by oxidation, the SS bond of cystine is oxidized to produce cysteic acid. For this reason, about the composition for cosmetics of Example 1, the quantity of the cysteic acid in the hair produced by an ultraviolet-ray was quantified. Human black hair (Beaulux Co., Ltd.) was washed with a 1% aqueous sodium lauryl sulfate solution, then washed with water and air dried.
  • Example 1 After cutting to about 5 cm and fixing to the holder, the infrared absorption spectrum was measured, and the ratio of the absorption wavelength of cysteic acid residue (1040 cm -1 ) to the absorption wavelength of amide (1634 cm -1 ) was calculated (Affinity -1, DuraSamplIR II, Shimadzu Corporation). Thereafter, water or the aqueous solution of Example 1 diluted to 5% was applied and completely dried with a dryer. The hair was irradiated with ultraviolet rays (about 300 J / cm 2 , 70 hours) under a UVB lamp. Then, it was made to wash and dry, and the infrared absorption spectrum was measured again. It was confirmed in advance that this condition had no effect on the spectrum due to the formulation application of Example 1.

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