WO2018062605A1 - Composition de dentifrice contenant un extrait galénique - Google Patents

Composition de dentifrice contenant un extrait galénique Download PDF

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Publication number
WO2018062605A1
WO2018062605A1 PCT/KR2016/011898 KR2016011898W WO2018062605A1 WO 2018062605 A1 WO2018062605 A1 WO 2018062605A1 KR 2016011898 W KR2016011898 W KR 2016011898W WO 2018062605 A1 WO2018062605 A1 WO 2018062605A1
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Prior art keywords
extract
weight
toothpaste composition
toothpaste
herbal
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PCT/KR2016/011898
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English (en)
Korean (ko)
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정원태
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셀포원
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Priority to CN201680088827.XA priority Critical patent/CN109843264A/zh
Publication of WO2018062605A1 publication Critical patent/WO2018062605A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • A61K8/988—Honey; Royal jelly, Propolis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Definitions

  • the present invention relates to a dentifrice composition containing the herbal extract.
  • the number of bacteria in saliva level of 10 8 ⁇ 10 9 CFU / ml is detected.
  • the teeth are perforated with a number of fine holes, so that the bacteria causing tooth decay enter the holes and make the teeth sick.
  • This tooth decay is one of the most common diseases seen in teeth, also known as dental caries. It is an infectious bacterial disease in which food in the mouth is rotted by acid-resistant streptococci and lactic acid bacteria and the components of teeth are destroyed by acid. In Korea, the prevalence of tooth decay is about 80%, and one person has an average of 2 to 3 caries.
  • the plaque is mixed with various bacteria, especially acid-resistant streptococci and lactic acid bacteria, among which Streptococcus mutans is known as the main caries.
  • Streptococcus mutans grows by attaching to the surface of the tooth, producing acid using sugar in the food to corrode the tooth, and at the same time invading tooth bone cells, causing various alveolar bone erosion and gum disease.
  • the development of tooth decay is the first step in which the plaque is formed on the surface of the plaque by the bacteria causing the tooth decay, and the second step is the process in which the organic acid is produced in the plaque.
  • the third step is to demineralize the inorganic matter constituting the tooth surface and further dissolve the organic matter.
  • plaque attached to the periodontal tissue and periodontal tissue is the main cause of the development and progression of periodontal disease, which is caused by the generation of harmful metabolites or bacterial enzymes caused by bacteria in the plaque, resulting in gingivitis It is known to make progress.
  • Bad breath refers to odors derived from the oral cavity and neighboring organs, and many people have an inconvenience in daily life due to bad breath. 85-90% of bad breath comes from the oral cavity, especially from the back of the tongue.
  • the main components of bad breath are volatile sulfur compounds, of which 90% of the total amount of volatile sulfur compounds is hydrogen sulfide made from cysteine and methyl mercaptan and dimethyl sulfide made from methionine. These components are mainly produced by protein enzymes secreted by anaerobic bacteria, and the back of the tongue is the most important habitat. This area is not well cleaned by saliva, and there are many small depressions, which is a place where bacteria continue to live.
  • tongue tonguers are used to remove tongue growth from the tongue.
  • Metal salts such as zinc chloride or disinfectants such as alcohol or chlorhexidine were used to remove or inhibit the growth of anaerobic bacteria or the generation of volatile sulfur compounds by anaerobic bacteria.
  • these metal salts and disinfectants suppress the development of not only anaerobic bacteria that cause bad breath, but also other microorganisms in the oral cavity. Since these substances do not swallow into the esophagus, they do not reach the back of the tongue, which is an important place for bad breath, and is mainly used in front of the mouth.
  • Toothpaste is a quasi-drug that is used to brush the surface of teeth.
  • toothpaste is mainly used for the purpose of whitening, bactericidal, and interdental cleansing.
  • toothpaste generally contains ingredients such as abrasives, wetting agents, foaming agents, and sweeteners. It is made to include.
  • abrasives e.g., abrasives, wetting agents, foaming agents, and sweeteners. It is made to include.
  • abrasives e.g., abrasives, wetting agents, foaming agents, and sweeteners. It is made to include.
  • Recently, many researches have been conducted for the preparation of various functional toothpastes to improve caries, periodontitis, and bad breath inhibitory effects.
  • periodontal disease has recently attracted attention as a risk factor for not only chronic infection of gum tissue but also causing myocardial infarction, arteriosclerosis, diabetes and premature birth. Therefore, it may suggest that toothpaste may be the basis for improving various health conditions
  • Grapefruit seeds contain ascorbic acid, phenolic compounds, naringin and tocophenols, which have been reported to weaken the function of cell walls and membranes of rot and pathogenic microorganisms and to inhibit enzymatic activity. It has been reported to prevent the cell proliferation mechanism derived from the bactericidal effect on bacteria, yeast and mold, and to increase the freshness and shelf life of food by inhibiting the production of toxic decay products.
  • grapefruit seed extract is a natural food preservative, LD value of 2,900 mg / kg almost no toxicity, no corrosive, very stable to the heat is a stable natural antibacterial agent does not cause environmental pollution.
  • Eucalyptus sp. Is a plant that grows mainly in the tropics and has more than 750 species.
  • the amount of essential oil contained in eucalyptus leaves is about 2-7%.
  • the essential oil is a colorless to pale yellow transparent liquid with a characteristic stinging aroma and taste that is irritating or refreshing.
  • Eucalyptus is used in soaps, liqueurs, fragrances, and medicines, and is particularly used in antiseptics, expectorants, insect repellents, mouthwashes, antitussives, and disinfectants.
  • Sage is a medicinal plant that has long been known as a panacea.
  • Sage is an English name that is changed from French to Sauge and is often called Salvia. It comes from the meaning of 'healthy', 'cure' and 'rescue'.
  • Sage is used to dry the leaves, in addition to the tonic effect on the nervous system and digestive system has an excellent effect.
  • Aloe is a botanical shrub and succulent plant belonging to the genus Aloe of the Liliaceae family. There are over 500 species of Aloe genus, but only 6-7 species of medicinal aloe. Africa is of origin. The juice of fresh aloe leaves is internalized in gastrointestinal diseases and externalized on trauma and burns. Since the end of World War II, the ingredients of aloe have been revealed one after another. So far, the results show that it contains aloetin, a bactericidal and fungal neutralizing agent for bacteria and fungi, aloeursine for ulcers, and aloemitin for anticancer activity. In addition, it contains various ingredients such as steroids, amino acids, saponins, antibiotics, wound healing hormones and minerals.
  • Aloe is effective in recovering from fatigue caused by overwork and relieving hangovers caused by excessive drinking, and cutting aloe leaves extraordinarily bitter yellow material, which is particularly effective in constipation.
  • aloe leaf juice is used for gastrointestinal diseases and used for trauma and burns. It also neutralizes dry and oily skin and moisturizes the skin, making it a cosmetic ingredient.
  • Chamomile includes German Chamomile, Roman Chamomile, Bodegold Chamomile, and Dyer's Chamomile, mainly known as German Chamomile and Roman Chamomile.
  • Chamomile essential oil has the effect of relieving tension and keeping you warm.
  • Chamomile is also effective for pain and inflammation, such as headaches, migraines and neuralgia. If you have gastrointestinal disorders, it is effective to drink it by car. Watering the flowers with the chamomile petals wither the flowers that are withering away quickly to restore vitality and heal the sick plants and prevent the onset.
  • German chamomile and Roman chamomile have almost the same effect, but German chamomile is used because it is less bitter.
  • Roman chamomile which is more fragrant than German chamomile, is often used as a plant in the garden or on the roadside.
  • Green tea (green tea) is a tea made using tea that has not been fermented. Drinking tea often prevents the formation of blood clots and lowers cholesterol and blood sugar. It is also effective in preventing tooth decay. Green tea extract has antioxidant activity. The bitter taste of green tea is due to a tannin called catechin. Catechin, a kind of antioxidant polyphenol, contains about 100mg of green tea, and EGCG (Epigallocatechin gallate), the most powerful ingredient, is known to have 20 times higher antioxidant activity than vitamin C. Catechin is known to act as an anticancer effect and protect blood vessel health. Catechin has the effect of preventing stomach and lung cancer, lowers blood pressure and increases blood flow to the heart.
  • Propolis is made by mixing bees and enzymes with resin-like substances extracted from various plants for the survival and breeding of bees.
  • the components are organic matter and minerals (inorganic salts).
  • the most, minerals, vitamins, amino acids, fats, organic acids, flavonoids, etc. play an important role in cell metabolism, terpenes, etc. have an anticancer effect.
  • the main benefits are anti-inflammatory, antioxidant, and immune boosting.
  • the inventors of the present invention while studying the various physiological activities of the extract of the herbal, confirmed that the composition mixed with the extract has an inhibitory effect of various strains associated with dental caries, periodontal disease, bad breath, and completed the present invention .
  • Korean Patent No. 10-1062779 (Invention name: Bifidobacterium adolescents SPM1005 strain showing growth inhibitory activity of the caries-inducing bacteria and the Bifidobacterium adolescents SPM1005 strain or culture thereof Food and pharmaceutical composition for the prevention of tooth decay as an ingredient, Applicant: Sahmyook University Industry-Academic Cooperation Group, Registration Date: August 31, 2011)
  • the present invention relates to a toothpaste composition containing a herbal extract, and more particularly, to a toothpaste composition containing a herbal extract including grapefruit seed extract, eucalyptus extract, sage extract, aloe extract, chamomile extract, green tea extract and propolis extract. will be.
  • the herbal extract is based on 100 parts by weight of grapefruit seed extract, 10-130 parts by weight of eucalyptus extract, 10-130 parts by weight of sage extract, 10-130 parts by weight of aloe extract, 10-130 parts by weight of chamomile extract, green tea extract 10-130 It may be contained 1 part by weight to 20 parts by weight and propolis extract.
  • the herbal extract may be contained in the toothpaste composition 0.5 to 2% by weight.
  • the toothpaste composition may include silicon dioxide, allantoinchlorohydroxyaluminum, aminocaproic acid, concentrated glycerin, D-sorbitol solution, xanthan gum, xylitol, sodium chloride, tocopherol acetate, sodium cocoyl glutamate, grapefruit flavor and purified water.
  • the toothpaste composition 10 to 20% by weight of silicon dioxide, 0.01 to 1% by weight of allantoinchlorohydroxyaluminum, 0.05 to 0.2% by weight of aminocaproic acid, 3 to 7% by weight of concentrated glycerin, 55 to D-sorbitol solution 70% by weight, xanthan gum 0.5-1.2% by weight, xylitol 0.05-0.2% by weight, sodium chloride 0.01-0.1% by weight, tocopherol acetate 0.005-0.02% by weight, sodium cocoyl glutamate 0.5-2% by weight, grapefruit flavor 0.3-0.5% % And purified water 10 to 20% by weight may be included.
  • the toothpaste composition is characterized in that it has an antimicrobial effect against the strain causing the caries Streptococcus mutans ( Streptococcus mutans).
  • the dentifrice composition is a cause of periodontitis, or bad breath, fatigue formate Pseudomonas seriously balise (Porphyromonas gingivalis), frame beams inter telra media (Prevotella intermedia ), Fusobacterium nucleatum ), Bacteoides forsythus and Treponema deticola ( Treponema deticola ) is characterized in that it has an antimicrobial effect against at least one strain selected from the group consisting of.
  • the present invention is a herbal extract, including grapefruit seed extract, eucalyptus extract, sage extract, aloe extract, chamomile extract, green tea extract and propolis extract, silicon dioxide, allantoin chlorohydroxyaluminum, aminocaproic acid, concentrated glycerin, D-
  • a method for preparing a dentifrice composition by mixing sorbitol solution, xanthan gum, xylitol, sodium chloride, tocopherol acetate, sodium cocoyl glutamate, grapefruit and purified water.
  • the present invention also provides a pharmaceutical composition for the prevention or treatment of tooth decay or periodontitis containing a herbal extract, including grapefruit seed extract, eucalyptus extract, sage extract, aloe extract, chamomile extract, green tea extract and propolis extract.
  • a herbal extract including grapefruit seed extract, eucalyptus extract, sage extract, aloe extract, chamomile extract, green tea extract and propolis extract.
  • the present invention provides a health functional food for the prevention or improvement of caries, periodontitis or bad breath containing herbal extracts, including grapefruit seed extract, eucalyptus extract, sage extract, aloe extract, chamomile extract, green tea extract and propolis extract.
  • herbal extracts including grapefruit seed extract, eucalyptus extract, sage extract, aloe extract, chamomile extract, green tea extract and propolis extract.
  • the present invention relates to a toothpaste composition containing a herbal extract including grapefruit seed extract, eucalyptus extract, sage extract, aloe extract, chamomile extract, green tea extract and propolis extract, the herbal extract is 100 parts by weight of grapefruit seed extract As a basis, 10 to 130 parts by weight of eucalyptus extract, 10 to 130 parts by weight of sage extract, 10 to 130 parts by weight of aloe extract, 10 to 130 parts by weight of chamomile extract, 10 to 130 parts by weight of green tea extract and 1 to 20 parts by weight of propolis extract It may be contained in addition, if the content range of each extract is out of this it is not preferable because the antimicrobial effect or bad breath inhibitory effect of the toothpaste composition comprising the extract can be reduced.
  • the herbal extract may be added 0.1 ⁇ 5 parts by weight of bee venom extract on the basis of 100 parts by weight of grapefruit seed extract, through the addition of bee venom can significantly increase the antibacterial or bad breath inhibitory effect of the herbal extract.
  • the bee venom is a purified bee venom, and is preferably collected from worker bees of 15-day-old or more Western bees.
  • the herbal extract may be contained in the toothpaste composition 0.5 to 2% by weight.
  • Toothpaste compositions of the present invention also include silicon dioxide, allantoinchlorohydroxyaluminum, aminocaproic acid, concentrated glycerin, D-sorbitol solution, xanthan gum, xylitol, sodium chloride, tocopherol acetate, sodium cocoyl glutamate, grapefruit flavor and purified water.
  • 10 to 20% by weight of silicon dioxide, 0.01 to 1% by weight of allantoinchlorohydroxyaluminum, 0.05 to 0.2% by weight of aminocaproic acid, 3 to 7% by weight of concentrated glycerin, D-sorbitol solution 55 70 wt%, xanthan gum 0.5-1.2 wt%, xylitol 0.05-0.2 wt%, sodium chloride 0.01-0.1 wt%, tocopherol acetate 0.005-0.02 wt%, sodium cocoyl glutamate 0.5-2 wt%, grapefruit flavor 0.3-0.5 Wt% and purified water may include 10 to 20% by weight.
  • the content of each component is out of this range, the physical properties of the toothpaste composition is not maintained well or the preservation effect of the toothpaste containing the herbal extract may be worse. In addition, the antimicrobial and bad breath inhibitory effects of the toothpaste composition may be reduced.
  • the grapefruit seed extract, eucalyptus extract, sage extract, aloe extract, chamomile extract, green tea extract is a plant or seed, propolis ingot to be extracted each extract water, C1 ⁇ C4 alcohol or a mixture thereof as a solvent
  • the C1 ⁇ C4 alcohol may be selected from the group consisting of methanol, ethanol, propanol, isopropanol, butanol and isobutanol.
  • Water, C1 ⁇ C4 alcohol or a mixed solution thereof used in the preparation of the plant or seed extract may be used 1 to 40 times the volume (1 to 40 L per 1kg) based on the plant or seed use weight, preferably 5 ⁇ 40 times the volume can be used.
  • Extraction conditions of the extract may be 1 minute to 48 hours at 20 ⁇ 100 °C. The process may be repeated 1 to 4 times.
  • the preparation temperature of the extract may be 20 to 100 °C, but is not limited thereto. Extraction time is not particularly limited, but is preferably extracted within 10 minutes to 2 days, it is possible to use a conventional extraction device, ultrasonic grinding extractor or fractionator as the extraction device. Each extract thus prepared may be removed by hot air drying, reduced pressure drying or lyophilization.
  • Propolis extract is also the same as the plant or seed extract manufacturing conditions except that the raw material to the propolis ingot.
  • Solid content of the extract of the present invention may be 1 to 90% by weight.
  • each extract that can be used most preferably in the present invention 5 ⁇ 30 ⁇ 90% (v / v) ethanol aqueous solution 1 ⁇ 30% compared to the raw material samples (grape seed, eucalyptus, sage, aloe, chamomile, green tea or propolis) It is good to use the extract which is obtained by adding 20 times the volume (5 ⁇ 20L per 1kg) to the dark shade.
  • the present invention provides a pharmaceutical composition for the prevention or treatment of tooth decay or periodontitis containing a herbal extract, including grapefruit seed extract, eucalyptus extract, sage extract, aloe extract, chamomile extract, green tea extract and propolis extract.
  • a herbal extract including grapefruit seed extract, eucalyptus extract, sage extract, aloe extract, chamomile extract, green tea extract and propolis extract.
  • the herbal extract may be added as 0.001 to 100% by weight to the pharmaceutical composition of the present invention.
  • compositions may be used in the form of powders, granules, tablets, capsules, suspensions, emulsions, syrups, aerosols and the like, oral formulations, external preparations, suppositories, and sterile injectable solutions, respectively, according to a conventional method.
  • Carriers, excipients and diluents that may be included in the pharmaceutical composition include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, cellulose , Methyl cellulose, microcrystalline cellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil.
  • Solid preparations for oral administration include tablets, pills, powders, granules, capsules, and the like, and such solid preparations include at least one excipient such as starch, calcium carbonate, sucrose or lactose in the herbal extract of the present invention. Mixed with gelatin.
  • lubricants such as magnesium stearate and talc are also used.
  • Oral liquid preparations include suspensions, solvents, emulsions, and syrups, and may include various excipients, such as wetting agents, sweeteners, fragrances, and preservatives, in addition to commonly used simple diluents such as water and liquid paraffin.
  • Formulations for parenteral administration include sterile aqueous solutions, non-aqueous solvents, suspensions, emulsions, lyophilized preparations, suppositories.
  • the non-aqueous solvent and suspending agent propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate and the like can be used.
  • As the base of the suppository witepsol, macrogol, tween 61, cacao butter, laurin butter, glycerogelatin and the like can be used.
  • the dosage of the pharmaceutical composition of the present invention will vary depending on the age, sex, weight of the subject to be treated, the specific disease or pathology to be treated, the severity of the disease or pathology, the route of administration and the judgment of the prescriber. Dosage determination based on these factors is within the level of skill in the art and generally dosages range from 0.01 mg / kg / day to approximately 2000 mg / kg / day. More preferred dosage is 1 mg / kg / day to 500 mg / kg / day. Administration may be administered once a day or may be divided several times. The dosage does not limit the scope of the invention in any aspect.
  • the pharmaceutical composition of the present invention can be administered to mammals such as rats, livestock, humans, etc. by various routes. All modes of administration can be expected, for example, by oral, rectal or intravenous, intramuscular, subcutaneous, intrauterine dural or cerebrovascular injections. Since the extract of the present invention has little toxicity and side effects, it is a drug that can be used safely even when taken for long periods of time.
  • the present invention is a cavities, periodontitis or bad breath comprising a herbal extract and a pharmaceutically acceptable food supplement additive, including grapefruit seed extract, eucalyptus extract, sage extract, aloe extract, chamomile extract, green tea extract and propolis extract
  • a pharmaceutically acceptable food supplement additive including grapefruit seed extract, eucalyptus extract, sage extract, aloe extract, chamomile extract, green tea extract and propolis extract
  • the herbal extract may be added as 0.001 to 100% by weight to the health functional food of the present invention.
  • the health functional food of the present invention includes the form of tablets, capsules, pills, or liquids, and the food to which the extract of the present invention can be added includes, for example, various drinks, meats, sausages, breads, candy, Snacks, noodles, ice cream, dairy products, soups, ionic drinks, beverages, alcoholic beverages, gum, tea and vitamin complexes.
  • the present invention relates to a toothpaste composition containing a herbal extract, including grapefruit seed extract, eucalyptus extract, sage extract, aloe extract, chamomile extract, green tea extract and propolis extract, the composition comprising the herbal extract is caries, periodontitis Or antibacterial effect on the causative bacteria of bad breath.
  • the composition containing the herbal extract can be easily used as a pharmaceutical composition for the prevention or treatment of tooth decay or periodontitis, as well as health functional food for the prevention or improvement of tooth decay, periodontitis or bad breath.
  • Herbal extract was prepared by mixing each extract in the component ratio of Table 1 below. Each extract was used to concentrate the extract obtained by adding 70% (v / v) ethanol aqueous solution 10 times the volume (10 l per kg) compared to the raw material samples.
  • Example 1-1 100 50 50 50 50 5
  • Example 1-2 100 10 90 10 90 35 20
  • Example 1-3 100 30 50 130 30 10 5
  • Example 1-4 100 80 10 35 10 110 10
  • Example 1-5 100 130 20 55
  • Example 1-6 100 30 30 20 130 30 15
  • Example 1-7 100 20 130 10 30 50 15
  • Example 1-8 100 35 30 30 10 130 20
  • a herbal extract was prepared in the same manner as in Example 1-1, but 49 g of green tea extract was added and 1 g of purified bee venom was added.
  • Toothpaste was prepared by mixing the herbal extract and each component in the ingredient ratio of Table 2 below.
  • Example 1-1 extract 0.71 (Example 1-3 extract) 0.71 (Example 1-5 extract) 0.71 (Example 1-7 extract) 0.5 (Example 1-1 extract) 2 (Example 1-1 extract) 0.71 (Example 1-9 extract) Silicon dioxide (g) 15 15 15 15 10 20 15 Allantoinchlorohydroxyaluminum (g) 0.1 0.1 0.1 0.1 0.3 0.05 0.1 Aminocaproic acid (g) 0.12 0.12 0.12 0.12 0.2 0.05 0.12 Concentrated glycerin (g) 5 5 5 5 7 3.53 5 Sorbitol Liquid (g) 62 62 62 62 70 55 62 Xanthan Gum (g) 0.8 0.8 0.8 0.8 0.5 1.2 0.8 Xylitol (g) 0.1 0.1 0.1 0.2 0.05 0.1 Sodium chloride (g)
  • Toothpaste was prepared by mixing the herbal extract with each component in the ingredient ratio of Table 4 below.
  • TSB trypticase soy broth
  • hemin menadione for bacterial culture used in the present invention 50 ml of herbal extract dilution solution, and 50 ml of strain dilution
  • the cells were incubated at 37 ° C. for 24 hours while measuring absorbance values using a UV-spectrophotometer every 4 hours.
  • the minimum concentration at which the growth (turbidity) of the strain is not detected on the growth curve of the bacteria was set as the minimum growth inhibitory concentration.
  • Example 1-1 4.4 4.9 2.4
  • Example 1-2 5.7 8.6 9.3
  • Example 1-3 6.6 4.7 4.4
  • Example 1-4 3.1 5.4 7.7
  • Example 1-5 2.3 2.2
  • Example 1-6 8.2
  • Example 1-7 5.5 5.7 3.8
  • Example 1-8 4.4 3.8 7.6
  • Example 1-9 1.5 1.9 1.8 Comparative Example 1-1 55.4 56.0 66.4
  • Comparative Example 1-2 48.6 77.6 54.7 Comparative Example 1-3 60.5 64.5 62.6
  • Example 2 and Comparative Example 2 of the present invention was distributed to 50 adult men and women, and after two months of use, the effects of inhibiting bad breath and gum inflammation were compared with those of the conventional commercially available toothpaste. It was shown by the RBI method (1 point: very bad, 2 points: bad, 3 points: normal, 4 points: good, 5 points: very good).
  • Example 1-1 of the present invention 200 g of the herbal extract of Example 1-1 of the present invention was mixed with 175.9 g of lactose, 180 g of potato starch, and 32 g of colloidal silicic acid. 10% gelatin solution was added to the mixture, which was then ground and passed through a 14 mesh sieve. It was dried and the mixture obtained by adding 160 g of potato starch, 50 g of talc and 5 g of magnesium stearate was made into a tablet.
  • the herbal extract of Inventive Example 1-1 of the present invention was added to the cooking seasoning at 1% by weight to prepare a cooking seasoning for health promotion.
  • the herbal extract of Inventive Example 1-1 of the present invention was added to flour at 0.1 wt%, and bread, cake, cookies, crackers, and noodles were prepared using the mixture to prepare foods for health promotion.
  • the herbal extract of Inventive Example 1-1 of the present invention was added to soup and broth in 0.1 wt% to prepare soup and broth for health promotion.
  • the herbal extract of Inventive Example 1-1 of the present invention was added to milk at 0.1% by weight, and various dairy products such as butter and ice cream were prepared using the milk.
  • Example 1-1 of the present invention 0.1 g was added to 1,000 ml of apple juice or wine juice to prepare fruit juice for health promotion.

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Abstract

La présente invention concerne une composition de dentifrice contenant un extrait galénique comprenant un extrait de pépins de pamplemousse, un extrait d'eucalyptus, un extrait de sauge, un extrait d'aloès, un extrait de camomille, un extrait de thé vert et un extrait de propolis. La composition comprenant l'extrait galénique a un excellent effet antimicrobien sur les bactéries responsables de la carie dentaire, de la parodontite ou de l'halitose. Ainsi, la composition contenant l'extrait galénique peut être utilisée non seulement en tant que dentifrice mais également en tant que composition pharmaceutique pour prévenir ou traiter la carie dentaire ou la parodontite, et en tant qu'aliment fonctionnel pour la santé pour la prévention ou l'amélioration de la carie dentaire, de la parodontite, ou de l'halitose.
PCT/KR2016/011898 2016-09-27 2016-10-21 Composition de dentifrice contenant un extrait galénique WO2018062605A1 (fr)

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Cited By (3)

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WO2019231493A1 (fr) * 2018-05-30 2019-12-05 Radius Corporation Dentifrice à base de produits naturels
US11058628B2 (en) 2018-05-30 2021-07-13 Radius Corporation Organic toothpaste
RU2773191C1 (ru) * 2018-05-30 2022-05-31 Радиус Корпорейшн Органическая зубная паста

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KR102162661B1 (ko) * 2018-12-11 2020-10-07 주식회사 엘리바이오 로즈힙을 활성성분으로 함유하는 치약 조성물
KR102196459B1 (ko) * 2019-02-15 2020-12-30 주식회사 메디덴코 항균 성능이 개선된 치약 조성물 및 이를 포함하는 치약
KR102221423B1 (ko) * 2019-08-27 2021-03-02 주식회사 닥터이엘 구취 억제 및 구강 위생 증진용 구강청결제 조성물
KR102205548B1 (ko) * 2020-06-05 2021-01-20 신명섭 안태음 한약재 추출물 함유 치약 조성물
CN112754984A (zh) * 2021-03-11 2021-05-07 傅博 一种抗敏感的液体牙膏及其制备方法
KR102622954B1 (ko) * 2023-09-13 2024-01-09 강병조 치은염 및 치주염 개선 또는 예방 효과가 있는 치약 조성물
CN117860626A (zh) * 2023-09-14 2024-04-12 广州中科佰氏健康产业有限公司 一种含天然药物组合成分的抗口臭牙膏及其制备方法

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WO2019231493A1 (fr) * 2018-05-30 2019-12-05 Radius Corporation Dentifrice à base de produits naturels
US10758474B2 (en) 2018-05-30 2020-09-01 Radius Corporation Organic toothpaste
CN112218610A (zh) * 2018-05-30 2021-01-12 雷迪厄斯公司 有机牙膏
GB2587533A (en) * 2018-05-30 2021-03-31 Radius Corp Organic toothpaste
US11058628B2 (en) 2018-05-30 2021-07-13 Radius Corporation Organic toothpaste
US11253468B2 (en) 2018-05-30 2022-02-22 Radius Corporation Organic toothpaste
RU2773191C1 (ru) * 2018-05-30 2022-05-31 Радиус Корпорейшн Органическая зубная паста
GB2587533B (en) * 2018-05-30 2022-08-17 Radius Corp Organic toothpaste

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