CN117860626A - 一种含天然药物组合成分的抗口臭牙膏及其制备方法 - Google Patents
一种含天然药物组合成分的抗口臭牙膏及其制备方法 Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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Abstract
本发明涉及一种含天然药物组合成分的抗口臭牙膏及其制备方法，属于牙膏技术领域。本发明的抗口臭牙膏由以下原料组成：油橄榄、春黄菊、橘子皮、藿香、沉香、银杏叶、丁香、大黄、薄荷、红茶、三七根粉、溶菌酶、焦磷酸四钠、保湿剂、摩擦剂、表活剂、矫味剂、增稠剂、防腐剂、水。本发明所述的抗口臭牙膏具有较浓的芳香味，在一定程度上能够抑制、淡化口臭，改善口气，可长期使用，无毒副作用。
Description
技术领域
本发明属于牙膏技术领域，尤其涉及一种含天然药物组合成分的抗口臭牙膏及其制备方法。
背景技术
口气是指从口腔或其他生理空腔中如鼻、鼻窦、咽等所散发出的不愉快气体。口气的发生是多种因素综合作用的结果，包括口腔疾病、肠道疾病、饮食问题等，然而导致口气最普遍的原因是口腔细菌，且口腔细菌会导致口腔疾病，进一步的导致口腔异味，形成恶性循环。想要达到口气清新的目的可以从三个角度考虑：一是采用浓郁的气味来掩盖口气，快速起效清新口气，缩短人们的等待时间；二是能够消除口臭成分，延长抑制口气的维持时间；三是采用杀菌、抑菌的产品，解决口臭成分产生的根源。为此人们采用各种口腔护理产品来改善口腔卫生、维护口腔健康，如牙膏、牙刷、漱口水、口气清新剂、牙线、牙线棒等。
牙膏是人们日常生活中不可缺少的口腔清洁卫生用品，其基本功能在于清洁牙齿，使用后给人以清爽舒适的口气。近年来，随着人们口腔保健意识的不断提高和消费观念的逐渐理性化，以及天然、绿色、安全消费理念的增强，在选自口腔护理产品时，人们越来越注重产品的安全无害性，人们开始热衷于天然来源的、无毒无害的牙膏产品，含中草药或其提取物的牙膏越来越受到广大人们的青睐。专利CN 106491430A公开了一种金银花复方草本牙膏及其制备方法，CN 106309215A公开了一种含草本精华提取物的牙膏，上述牙膏虽然具有一定的抑制口腔有害细菌、清新口气、保护牙齿、防治口腔疾病等功能，但由于使用的中草药成分比较单一，有效成分含量更低，导致实际护齿保健效果不够理想。目前，市场上还鲜见采用天然药物在口腔疗效保健方面达到显著效果的牙膏。
发明内容
为解决上述技术问题，本发明提供了一种含天然药物组合成分的抗口臭牙膏及其制备方法。
本发明的第一个目的是提供一种含天然药物组合成分的抗口臭牙膏，按重量份数计由以下原料组成：油橄榄1-5份、春黄菊1-5份、橘子皮1-5份、藿香1-5份、沉香1-5份、银杏叶1-5份、丁香1-5份、大黄1-5份、薄荷1-5份、红茶5-10份、三七根粉1-5份、溶菌酶0.1-0.2份、焦磷酸四钠0.1-0.2份、保湿剂30-50份、摩擦剂15-20份、表活剂1.5-2.5份、矫味剂1.0-2.0份、增稠剂0.2-1.5份、防腐剂0.2-1份、水15-30份。
进一步地，所述含天然药物组合成分的抗口臭牙膏，按重量份数计由以下原料组成：油橄榄3份、春黄菊3份、橘子皮3份、藿香3份、沉香3份、银杏叶3份、丁香3份、大黄3份、薄荷3份、红茶8份、三七根粉3份、溶菌酶0.15份、焦磷酸四钠0.15份、保湿剂40份、摩擦剂18份、表活剂2份、矫味剂1.5份、增稠剂1份、防腐剂0.6份、水25份。
在本发明的一个实施例中，所述保湿剂选自山梨醇、聚乙二醇、甘油和丙二醇中的一种或多种。
在本发明的一个实施例中，所述摩擦剂选自二氧化硅和/或焦磷酸钙。
在本发明的一个实施例中，所述表活剂包括月桂醇硫酸酯钠和月桂酰肌氨酸钠。
在本发明的一个实施例中，所述矫味剂包括香精、赤藓醇和糖精钠；所述香精、赤藓醇和糖精钠的质量比为0.5-1：0.5-1：0.1-0.3。
在本发明的一个实施例中，所述增稠剂选自黄原胶、纤维素胶、羧甲基纤维素和羟乙基纤维素中的一种或多种。
在本发明的一个实施例中，所述防腐剂选自苯甲酸钠、山梨酸钾和对羟基苯甲酸盐中的一种或多种。
本发明的第二个目的是提供一种所述的含天然药物组合成分的抗口臭牙膏的制备方法，包括以下步骤，
S1、油橄榄、春黄菊、橘子皮、藿香、沉香、银杏叶、丁香、大黄、薄荷、红茶和三七根粉进行粉碎至180-200目，混合后加入5-10倍量的乙醇溶液进行浸泡，后加热至40℃-100℃煎煮0.5h-1h，提取1-3次，合并过滤液，得到提取物；
将溶菌酶、焦磷酸四钠、保湿剂、摩擦剂、表活剂、矫味剂、增稠剂、防腐剂和水混合，搅拌均匀，得到混合物；
S2、在混合物中加入提取物，搅拌10min-30min，接着在真空条件下搅拌3min-8min，得到含天然药物组合成分的抗口臭牙膏。
在本发明的一个实施例中，在S1中，所述浸泡的时间为3h-4h。
在本发明的一个实施例中，在S2中，所述真空条件的真空度为-0.08MPa至-0.1MPa。
本发明的技术方案相比现有技术具有以下优点：
(1)本发明添加的丁香提取物中含有丁香酚，是天然抗菌剂，具有很强的杀菌力，对人体安全无害。丁香酚具有镇痛麻醉、抗菌抑菌、抗氧化、解热、抗肿瘤、促进透皮吸收等作用。
(2)本发明添加的大黄提取物中含有芦荟大黄素、大黄酸、大黄素、大黄酚、大黄素甲醚等成分。且大黄有凉血解毒散上炎之火的作用，用于治疗胃火牙痛、口腔溃疡、口臭、异味、牙周炎等口腔问题。
(3)本发明添加的沉香提取物不仅气味清新独特，同时具有行气止痛、温中止呕、纳气平喘、养心安神、通脉降气之功效，沉香与其他药材的配伍，达到更好的消炎止血、清新口气以及抑制口腔溃疡等功效；该牙膏在刷牙后能够均匀持久的释放香味，通过鼻腔吸入，再经过肺的气体交换进入体内，达到闻香治病的效果。
(4)本发明添加的油橄榄提取物中含有胆碱、茶多酚、芦丁、甜菊糖甙、多种蛋白质、多种维生素、多种微量元素，含天然抗氧化物。橄榄叶中还含有列环烯醚萜，具广普抗菌、抗病毒作用，这些成分不经过溶菌酶，难释放出来。
(5)本发明通过在原料中添加油橄榄、薄荷、红茶银杏叶、大黄、三七根粉等中药，使牙膏具有防腐杀菌、消炎解热、具有杀菌和抑制的效果；通过在原料中添加春黄菊、藿香、沉香、丁香、橘子皮等中药，使牙膏具有清热去臭、芳香化浊、气味清香且不易流散的效果。
(6)本发明所述的抗口臭牙膏将溶菌酶与油橄榄、春黄菊、橘子皮、藿香、沉香、银杏叶、丁香、大黄等复合使用，弥补了单一溶菌酶或者常规提取物抗菌杀菌能力不足的缺陷，在增强牙膏抑菌杀菌效果的同时，达到了很好的去除口腔异味和清新口气的作用。
(7)本发明所述的抗口臭牙膏具有较浓的芳香味，在一定程度上能够抑制、淡化口臭，改善口气，可长期使用，无毒副作用。
具体实施方式
下面结合具体实施例对本发明作进一步说明，以使本领域的技术人员可以更好地理解本发明并能予以实施，但所举实施例不作为对本发明的限定。
在本发明中，除非另有说明，本实施例中所采用到的材料及设备均可从市场购得。
实施例1
本发明的含天然药物组合成分的抗口臭牙膏，原料组分及其质量份如下：
油橄榄3份、春黄菊3份、橘子皮3份、藿香3份、沉香3份、银杏叶3份、丁香3份、大黄3份、薄荷3份、红茶8份、三七根粉3份、溶菌酶0.15份、焦磷酸四钠0.15份、山梨醇20份、聚乙二醇-40020份、二氧化硅18份、月桂醇硫酸酯钠2份、香精0.6份、赤藓醇0.6份、糖精钠0.3份、黄原胶0.5份、纤维素胶0.5份、苯甲酸钠0.6份、水25份。
具体包括以下步骤：
S1、油橄榄、春黄菊、橘子皮、藿香、沉香、银杏叶、丁香、大黄、薄荷、红茶和三七根粉进行粉碎至200目，混合后加入8倍量的乙醇溶液进行浸泡3.5h，后加热至60℃煎煮45min，提取2次，合并过滤液，得到提取物；
将溶菌酶、焦磷酸四钠、山梨醇、聚乙二醇-400、二氧化硅、月桂醇硫酸酯钠、香精、赤藓醇、糖精钠、黄原胶、纤维素胶、苯甲酸钠和水混合，搅拌均匀，得到混合物；
S2、在混合物中加入提取物，搅20min，接着在真空度约为-0.09MPa条件下搅拌5min，得到含天然药物组合成分的抗口臭牙膏。
实施例2
本发明的含天然药物组合成分的抗口臭牙膏，原料组分及其质量份如下：
油橄榄1份、春黄菊1份、橘子皮1份、藿香1份、沉香1份、银杏叶5份、丁香5份、大黄5份、薄荷5份、红茶8份、三七根粉5份、溶菌酶0.1份、焦磷酸四钠0.2份、山梨醇20份、聚乙二醇-40020份、二氧化硅15份、月桂醇硫酸酯钠1.5份、香精0.6份、赤藓醇0.6份、糖精钠0.3份、黄原胶0.5份、纤维素胶1份、苯甲酸钠0.2份、水15份。
具体包括以下步骤：
S1、油橄榄、春黄菊、橘子皮、藿香、沉香、银杏叶、丁香、大黄、薄荷、红茶和三七根粉进行粉碎至200目，混合后加入10倍量的乙醇溶液进行浸泡4h，后加热至100℃煎煮1h，提取3次，合并过滤液，得到提取物；
将溶菌酶、焦磷酸四钠、山梨醇、聚乙二醇-400、二氧化硅、月桂醇硫酸酯钠、香精、赤藓醇、糖精钠、黄原胶、纤维素胶、苯甲酸钠和水混合，搅拌均匀，得到混合物；
S2、在混合物中加入提取物，搅拌30min，接着在真空度约为-0.1MPa条件下搅拌8min，得到含天然药物组合成分的抗口臭牙膏。
实施例3
本发明的含天然药物组合成分的抗口臭牙膏，原料组分及其质量份如下：
油橄榄5份、春黄菊5份、橘子皮5份、藿香5份、沉香5份、银杏叶1份、丁香1份、大黄1份、薄荷1份、红茶8份、三七根粉1份、溶菌酶0.2份、焦磷酸四钠0.1份、山梨醇20份、聚乙二醇-40020份、二氧化硅20份、月桂酰肌氨酸钠2.5份、香精0.6份、赤藓醇0.6份、糖精钠0.3份、黄原胶0.1份、纤维素胶0.1份、苯甲酸钠1份、水30份。
具体包括以下步骤：
S1、油橄榄、春黄菊、橘子皮、藿香、沉香、银杏叶、丁香、大黄、薄荷、红茶和三七根粉进行粉碎至180目，混合后加入5倍量的乙醇溶液进行浸泡3h，后加热至40℃煎煮0.5h，提取1次，得到提取物；
将溶菌酶、焦磷酸四钠、山梨醇、聚乙二醇-400、二氧化硅、月桂酰肌氨酸钠、香精、赤藓醇、糖精钠、黄原胶、纤维素胶、苯甲酸钠和水混合，搅拌均匀，得到混合物；
S2、在混合物中加入提取物，搅拌10min，接着在真空度约为-0.08MPa条件下搅拌3min，得到含天然药物组合成分的抗口臭牙膏。
实施例4
本发明的含天然药物组合成分的抗口臭牙膏，原料组分及其质量份如下：
油橄榄1份、春黄菊1份、橘子皮1份、藿香1份、沉香1份、银杏叶1份、丁香1份、大黄1份、薄荷1份、红茶10份、三七根粉5份、溶菌酶0.2份、焦磷酸四钠0.2份、山梨醇40份、聚乙二醇-40010份、二氧化硅20份、月桂酰肌氨酸钠2.5份、香精0.6份、赤藓醇0.6份、糖精钠0.3份、黄原胶1份、纤维素胶0.5份、苯甲酸钠1份、水30份。
具体包括以下步骤：
S1、油橄榄、春黄菊、橘子皮、藿香、沉香、银杏叶、丁香、大黄、薄荷、红茶和三七根粉进行粉碎至200目，混合后加入8倍量的乙醇溶液进行浸泡3.5h，后加热至60℃煎煮45min，提取2次，合并过滤液，得到提取物；
将溶菌酶、焦磷酸四钠、山梨醇、聚乙二醇-400、二氧化硅、月桂酰肌氨酸钠、香精、赤藓醇、糖精钠、黄原胶、纤维素胶、苯甲酸钠和水混合，搅拌均匀，得到混合物；
S2、在混合物中加入提取物，搅20min，接着在真空度约为-0.09MPa条件下搅拌5min，得到含天然药物组合成分的抗口臭牙膏。
实施例5
本发明的含天然药物组合成分的抗口臭牙膏，原料组分及其质量份如下：
油橄榄5份、春黄菊5份、橘子皮5份、藿香5份、沉香5份、银杏叶5份、丁香5份、大黄5份、薄荷5份、红茶5份、三七根粉1份、溶菌酶0.1份、焦磷酸四钠0.1份、山梨醇20份、聚乙二醇-40010份、二氧化硅15份、月桂酰肌氨酸钠1.5份、香精0.6份、赤藓醇0.6份、糖精钠0.3份、黄原胶0.1份、纤维素胶0.1份、苯甲酸钠0.2份、水15份。
具体包括以下步骤：
S1、油橄榄、春黄菊、橘子皮、藿香、沉香、银杏叶、丁香、大黄、薄荷、红茶和三七根粉进行粉碎至200目，混合后加入8倍量的乙醇溶液进行浸泡3.5h，后加热至60℃煎煮45min，提取2次，合并过滤液，得到提取物；
将溶菌酶、焦磷酸四钠、山梨醇、聚乙二醇-400、二氧化硅、月桂酰肌氨酸钠、香精、赤藓醇、糖精钠、黄原胶、纤维素胶、苯甲酸钠和水混合，搅拌均匀，得到混合物；
S2、在混合物中加入提取物，搅20min，接着在真空度约为-0.09MPa条件下搅拌5min，得到含天然药物组合成分的抗口臭牙膏。
对比例1
基本同实施例1，不同之处在于不添加油橄榄。
对比例2
基本同实施例1，不同之处在于不添加沉香。
对比例3
基本同实施例1，不同之处在于不添加丁香。
对比例4
基本同实施例1，不同之处在于不添加大黄。
对比例5
基本同实施例1，不同之处在于不添加三七根粉。
对比例6
基本同实施例1，不同之处在于不添加橘子皮。
测试例1
选取Balb/C小鼠120只(雌雄各60只)，分为5组试验组(对应实施例1-5)和1组对照组，每组雌雄各10只，饲喂实施例1-5所得的提取物(浓度为0.8g/10mL)，给药前8h和给药后4h内禁食，但不禁水。每只小鼠按体重灌胃0.3mL/10g混悬液，每日早、中、晚各一次，每次给药间隔4h，共三次，连续观察7天。观察白鼠生长状态和活动饮食，鉴定血液学、血液生化学、脏器组织结构以及尿常规等。结果发现所有小白鼠均健康生存，无任何毒副作用；解剖观察心脏、肝脏、脾脏、肾脏、肺脏及肠组织状态，与对照组小白鼠比较无差异。该测试中小鼠的给药量相当于成人临床日用量的94倍，成人单次用量315倍，意味着本品用于成人是安全的。
测试例2去异味能力试验
对实施例1-5和对比例1-6中得到的牙膏与市面某品牌畅销的牙膏进行去异味能力和感受试验对比，实验结果具体如下表1所示：
表1
| 等级 | 蒜味 | 烟味 | 感受 |
| 实施例1 | 清新 | 清新 | 舒适 |
| 实施例2 | 清新 | 清新 | 舒适 |
| 实施例3 | 清新 | 清新 | 舒适 |
| 实施例4 | 清新 | 清新 | 舒适 |
| 实施例5 | 清新 | 清新 | 舒适 |
| 对比例1 | 轻微蒜味 | 轻微烟味 | 舒适 |
| 对比例2 | 轻微蒜味 | 轻微烟味 | 舒适 |
| 对比例3 | 轻微蒜味 | 轻微烟味 | 舒适 |
| 对比例4 | 轻微蒜味 | 轻微烟味 | 舒适 |
| 对比例5 | 轻微蒜味 | 轻微烟味 | 舒适 |
| 对比例6 | 轻微蒜味 | 轻微烟味 | 舒适 |
| 某品牌 | 轻微蒜味 | 轻微烟味 | 轻微刺激 |
从表1可以看出，本发明实施例1-5中制得的牙膏能有效去除口腔中的蒜味和烟味，且口感舒适、无刺激。可见本发明的牙膏可以有效解决口臭问题。
测试例3杀菌试验
试验菌为金黄色葡萄球菌ATCC6538株，大肠杆菌8099株，白色念珠ATCC10231株。采用载体定量杀菌试验，试验载体为10mm×10mm玻片，经压力蒸汽灭菌后，用滴染法染菌。菌液滴加量每片为0.01mL，每片染菌量为5×105cfu/mL-5×106cfu/mL，滴染菌液后置于37℃温箱内干燥30min用于试验。试验时将菌片染菌面覆盖于牙膏内，待作用到预定时间后，取出菌片，移入含玻璃珠和10mL中和剂的三角烧瓶内放康氏震荡器上震荡2min(365次/分)。取其原液或不同稀释度的稀释液0.5mL，用倾注法作活菌计数。所有试验样本均置于37℃培养箱内培养48h，观察最终结果。结果显示牙膏对金黄色葡萄球菌ATCC6538株、大肠杆菌8099株和白色念珠菌ATCC10231株的杀灭作用，牙膏在1min内对金黄色葡萄球菌、大肠杆菌和白色念珠菌的杀灭率均达到99.99％，2min全部达到100％。
显然，上述实施例仅仅是为清楚地说明所作的举例，并非对实施方式的限定。对于所属领域的普通技术人员来说，在上述说明的基础上还可以做出其它不同形式变化或变动。这里无需也无法对所有的实施方式予以穷举。而由此所引申出的显而易见的变化或变动仍处于本发明创造的保护范围之中。
Claims (10)
1.一种含天然药物组合成分的抗口臭牙膏，其特征在于，按重量份数计由以下原料组成：油橄榄1-5份、春黄菊1-5份、橘子皮1-5份、藿香1-5份、沉香1-5份、银杏叶1-5份、丁香1-5份、大黄1-5份、薄荷1-5份、红茶5-10份、三七根粉1-5份、溶菌酶0.1-0.2份、焦磷酸四钠0.1-0.2份、保湿剂30-50份、摩擦剂15-20份、表活剂1.5-2.5份、矫味剂1.0-2.0份、增稠剂0.2-1.5份、防腐剂0.2-1份、水15-30份。
2.根据权利要求1所述的含天然药物组合成分的抗口臭牙膏，其特征在于，所述保湿剂选自山梨醇、聚乙二醇、甘油和丙二醇中的一种或多种。
3.根据权利要求1所述的含天然药物组合成分的抗口臭牙膏，其特征在于，所述摩擦剂选自二氧化硅和/或焦磷酸钙。
4.根据权利要求1所述的含天然药物组合成分的抗口臭牙膏，其特征在于，所述表活剂包括月桂醇硫酸酯钠和月桂酰肌氨酸钠。
5.根据权利要求1所述的含天然药物组合成分的抗口臭牙膏，其特征在于，所述矫味剂包括香精、赤藓醇和糖精钠；所述香精、赤藓醇和糖精钠的质量比为0.5-1：0.5-1：0.1-0.3。
6.根据权利要求1所述的含天然药物组合成分的抗口臭牙膏，其特征在于，所述增稠剂选自黄原胶、纤维素胶、羧甲基纤维素和羟乙基纤维素中的一种或多种。
7.根据权利要求1所述的含天然药物组合成分的抗口臭牙膏，其特征在于，所述防腐剂选自苯甲酸钠、山梨酸钾和对羟基苯甲酸盐中的一种或多种。
8.权利要求1-7任一项所述的含天然药物组合成分的抗口臭牙膏的制备方法，其特征在于，包括以下步骤，
S1、油橄榄、春黄菊、橘子皮、藿香、沉香、银杏叶、丁香、大黄、薄荷、红茶和三七根粉进行粉碎至180-200目，混合后加入5-10倍量的乙醇溶液进行浸泡，后加热至40℃-100℃煎煮0.5h-1h，提取1-3次，合并过滤液，得到提取物；
将溶菌酶、焦磷酸四钠、保湿剂、摩擦剂、表活剂、矫味剂、增稠剂、防腐剂和水混合，搅拌均匀，得到混合物；
S2、在混合物中加入提取物，搅拌10min-30min，接着在真空条件下搅拌3min-8min，得到含天然药物组合成分的抗口臭牙膏。
9.根据权利要求8所述的含天然药物组合成分的抗口臭牙膏的制备方法，其特征在于，在S1中，所述浸泡的时间为3h-4h。
10.根据权利要求8所述的含天然药物组合成分的抗口臭牙膏的制备方法，其特征在于，在S2中，所述真空条件的真空度为-0.08MPa至-0.1MPa。
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Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103989596A (zh) * | 2014-04-30 | 2014-08-20 | 韩雁如 | 一种洋甘菊牙膏 |
| CN104887553A (zh) * | 2015-05-06 | 2015-09-09 | 广东雪洁日化用品有限公司 | 一种橄榄提取物制备的牙膏及其制备方法 |
| CN105106781A (zh) * | 2015-08-31 | 2015-12-02 | 济南伟传信息技术有限公司 | 一种治疗口臭的中药 |
| CN105748340A (zh) * | 2015-11-27 | 2016-07-13 | 肖建国 | 含有红茶提取物的牙膏及其制备方法 |
| CN106309210A (zh) * | 2016-06-12 | 2017-01-11 | 广州市海诗生物科技有限公司 | 一种中草药漱口水及其制备方法 |
| CN106726913A (zh) * | 2016-12-12 | 2017-05-31 | 上海芽庄奇楠酒业有限公司 | 一种沉香牙膏及其制备方法 |
| CN108685835A (zh) * | 2018-08-01 | 2018-10-23 | 金心国际商贸（深圳）有限公司 | 一种多功能漱口水 |
| CN109010149A (zh) * | 2018-10-25 | 2018-12-18 | 海南师范大学 | 一种沉香精油牙膏及其制备方法 |
| JP2019001739A (ja) * | 2017-06-14 | 2019-01-10 | 日新製糖株式会社 | サイクロデキストランおよびその誘導体の用途 |
| CN109843264A (zh) * | 2016-09-27 | 2019-06-04 | 森芙万有限公司 | 一种含有草药提取物的牙膏组合物 |
| CN115501164A (zh) * | 2022-09-19 | 2022-12-23 | 浙江爱尚日用品有限公司 | 一种抗口臭的牙膏及其制备方法 |
| CN115721594A (zh) * | 2022-12-17 | 2023-03-03 | 广东中森志健医药科技有限公司 | 一种含银杏提取物的牙膏及制备方法 |
-
2023
- 2023-09-14 CN CN202311185532.2A patent/CN117860626A/zh active Pending
Patent Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103989596A (zh) * | 2014-04-30 | 2014-08-20 | 韩雁如 | 一种洋甘菊牙膏 |
| CN104887553A (zh) * | 2015-05-06 | 2015-09-09 | 广东雪洁日化用品有限公司 | 一种橄榄提取物制备的牙膏及其制备方法 |
| CN105106781A (zh) * | 2015-08-31 | 2015-12-02 | 济南伟传信息技术有限公司 | 一种治疗口臭的中药 |
| CN105748340A (zh) * | 2015-11-27 | 2016-07-13 | 肖建国 | 含有红茶提取物的牙膏及其制备方法 |
| CN106309210A (zh) * | 2016-06-12 | 2017-01-11 | 广州市海诗生物科技有限公司 | 一种中草药漱口水及其制备方法 |
| CN109843264A (zh) * | 2016-09-27 | 2019-06-04 | 森芙万有限公司 | 一种含有草药提取物的牙膏组合物 |
| CN106726913A (zh) * | 2016-12-12 | 2017-05-31 | 上海芽庄奇楠酒业有限公司 | 一种沉香牙膏及其制备方法 |
| JP2019001739A (ja) * | 2017-06-14 | 2019-01-10 | 日新製糖株式会社 | サイクロデキストランおよびその誘導体の用途 |
| CN108685835A (zh) * | 2018-08-01 | 2018-10-23 | 金心国际商贸（深圳）有限公司 | 一种多功能漱口水 |
| CN109010149A (zh) * | 2018-10-25 | 2018-12-18 | 海南师范大学 | 一种沉香精油牙膏及其制备方法 |
| CN115501164A (zh) * | 2022-09-19 | 2022-12-23 | 浙江爱尚日用品有限公司 | 一种抗口臭的牙膏及其制备方法 |
| CN115721594A (zh) * | 2022-12-17 | 2023-03-03 | 广东中森志健医药科技有限公司 | 一种含银杏提取物的牙膏及制备方法 |
Non-Patent Citations (7)
| Title |
|---|
| 刘志杰等: "《经方中药学》", 31 August 2020, 吉林大学出版社, pages: 227 * |
| 危北海等: "《中西医结合-消化病学》", 31 May 2003, 人民卫生出版社, pages: 330 * |
| 国家食品药品监督管理总局: ""化妆品准用防腐剂"", 《化妆品安全技术规范》, 1 December 2016 (2016-12-01), pages 113 - 116 * |
| 潘宇: "《发现本草-常用中草药识别妙用公开课》", 30 June 2022, 湖南科学技术出版社, pages: 67 * |
| 郝建新等: "《百种入膳中药集释》", 30 September 2006, 科学技术文献出版社, pages: 279 * |
| 郭恒怡: "《中医实证芳疗全书》", 31 January 2022, 中国轻工业出版社, pages: 226 * |
| 陈雨田等: "《广西特产风味指南丛书》", 31 January 1985, 广西人民出版社, pages: 108 * |
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