CN106309746A - 一种中药组合物及其制备方法和口腔保健品 - Google Patents
一种中药组合物及其制备方法和口腔保健品 Download PDFInfo
- Publication number
- CN106309746A CN106309746A CN201610894244.8A CN201610894244A CN106309746A CN 106309746 A CN106309746 A CN 106309746A CN 201610894244 A CN201610894244 A CN 201610894244A CN 106309746 A CN106309746 A CN 106309746A
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- medicine composition
- preparation
- oral health
- lignum aquilariae
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 62
- 239000000203 mixture Substances 0.000 title claims abstract description 51
- 238000002360 preparation method Methods 0.000 title claims abstract description 29
- 230000036541 health Effects 0.000 title abstract description 7
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 15
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 15
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 12
- 230000003110 anti-inflammatory effect Effects 0.000 claims abstract description 10
- 239000000047 product Substances 0.000 claims description 23
- 244000110343 Elephantopus scaber Species 0.000 claims description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- 239000000706 filtrate Substances 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 229940079593 drug Drugs 0.000 claims description 11
- 238000002156 mixing Methods 0.000 claims description 9
- 238000010992 reflux Methods 0.000 claims description 9
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 8
- 210000000214 mouth Anatomy 0.000 claims description 7
- 230000000202 analgesic effect Effects 0.000 claims description 6
- 229940112822 chewing gum Drugs 0.000 claims description 6
- 235000015218 chewing gum Nutrition 0.000 claims description 6
- 239000006072 paste Substances 0.000 claims description 6
- 239000002671 adjuvant Substances 0.000 claims description 5
- JEGUKCSWCFPDGT-UHFFFAOYSA-N h2o hydrate Chemical compound O.O JEGUKCSWCFPDGT-UHFFFAOYSA-N 0.000 claims description 5
- 239000000606 toothpaste Substances 0.000 claims description 5
- 229940034610 toothpaste Drugs 0.000 claims description 5
- -1 filter Substances 0.000 claims description 4
- 235000013305 food Nutrition 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 239000000551 dentifrice Substances 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 230000006837 decompression Effects 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 12
- 239000003205 fragrance Substances 0.000 abstract description 11
- 244000052616 bacterial pathogen Species 0.000 abstract description 4
- 230000001760 anti-analgesic effect Effects 0.000 abstract description 2
- 241000271309 Aquilaria crassna Species 0.000 abstract 1
- 235000018142 Hedysarum alpinum var americanum Nutrition 0.000 abstract 1
- 240000006461 Hedysarum alpinum var. americanum Species 0.000 abstract 1
- 244000246386 Mentha pulegium Species 0.000 abstract 1
- 235000016257 Mentha pulegium Nutrition 0.000 abstract 1
- 235000004357 Mentha x piperita Nutrition 0.000 abstract 1
- 235000001050 hortel pimenta Nutrition 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 230000008961 swelling Effects 0.000 description 5
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 4
- 241000191967 Staphylococcus aureus Species 0.000 description 4
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 4
- 208000002925 dental caries Diseases 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 230000002045 lasting effect Effects 0.000 description 4
- 206010025482 malaise Diseases 0.000 description 4
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 4
- 239000013642 negative control Substances 0.000 description 4
- 230000036407 pain Effects 0.000 description 4
- 239000013641 positive control Substances 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 239000000811 xylitol Substances 0.000 description 4
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 4
- 235000010447 xylitol Nutrition 0.000 description 4
- 229960002675 xylitol Drugs 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 230000036772 blood pressure Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000006210 lotion Substances 0.000 description 3
- 239000002304 perfume Substances 0.000 description 3
- 231100000614 poison Toxicity 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 2
- 206010006326 Breath odour Diseases 0.000 description 2
- 244000025254 Cannabis sativa Species 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 208000032139 Halitosis Diseases 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 108010059993 Vancomycin Proteins 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 229960001138 acetylsalicylic acid Drugs 0.000 description 2
- 230000036592 analgesia Effects 0.000 description 2
- 230000006793 arrhythmia Effects 0.000 description 2
- 206010003119 arrhythmia Diseases 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- NKWPZUCBCARRDP-UHFFFAOYSA-L calcium bicarbonate Chemical compound [Ca+2].OC([O-])=O.OC([O-])=O NKWPZUCBCARRDP-UHFFFAOYSA-L 0.000 description 2
- 229910000020 calcium bicarbonate Inorganic materials 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 2
- 210000003169 central nervous system Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 210000005069 ears Anatomy 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 235000012907 honey Nutrition 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 208000031225 myocardial ischemia Diseases 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 239000003507 refrigerant Substances 0.000 description 2
- 230000035943 smell Effects 0.000 description 2
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 2
- 229960003165 vancomycin Drugs 0.000 description 2
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 1
- NFLGAXVYCFJBMK-RKDXNWHRSA-N (+)-isomenthone Natural products CC(C)[C@H]1CC[C@@H](C)CC1=O NFLGAXVYCFJBMK-RKDXNWHRSA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 240000006409 Acacia auriculiformis Species 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 241000984061 Aquilaria Species 0.000 description 1
- 241001533085 Aquilaria sinensis Species 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 239000003390 Chinese drug Substances 0.000 description 1
- 206010008631 Cholera Diseases 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 208000002064 Dental Plaque Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- NFLGAXVYCFJBMK-UHFFFAOYSA-N Menthone Chemical compound CC(C)C1CCC(C)CC1=O NFLGAXVYCFJBMK-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000007443 Neurasthenia Diseases 0.000 description 1
- 206010029333 Neurosis Diseases 0.000 description 1
- 206010029897 Obsessive thoughts Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000025157 Oral disease Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000194019 Streptococcus mutans Species 0.000 description 1
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 241000130764 Tinea Species 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229920003090 carboxymethyl hydroxyethyl cellulose Polymers 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000019504 cigarettes Nutrition 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 210000003026 hypopharynx Anatomy 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 229930007503 menthone Natural products 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 208000030194 mouth disease Diseases 0.000 description 1
- 208000015238 neurotic disease Diseases 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 208000010540 rapid respiration Diseases 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 201000000980 schizophrenia Diseases 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 208000003265 stomatitis Diseases 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/83—Thymelaeaceae (Mezereum family), e.g. leatherwood or false ohelo
- A61K36/835—Aquilaria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
- A61K36/515—Gentiana
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明涉及口腔卫生保健技术领域，特别涉及一种中药组合物及其制备方法和口腔保健品。该中药组合物由沉香、薄荷、三七、地胆草和甘草制成。本发明中药组合物能有效地起到抗菌、抗炎、镇痛、香味持久的作用，减少口腔内的病菌，降低龋齿的发病率。
Description
技术领域
本发明涉及口腔卫生保健技术领域，特别涉及一种中药组合物及其制备方法和口腔保健品。
背景技术
随着人民生活水平质量的不断提高，人们的生活节奏越来越快，工作应酬或亲朋好友聚会已成为极为平常的事情，而口腔异味成了人际交往中的一大困扰。长时间不注重口腔清洁的人，口腔内所含的残留食物容易滋生口腔内变形链球菌的生长，残留食物容易发酵成有害的牙斑酸，最后造成龋齿。患有龋齿、牙龈炎、牙周炎、口腔粘膜炎以及蛀牙、牙周病等口腔疾病的人，其口腔内容易滋生细菌，尤其是厌氧菌，其分解产生出了硫化物，发出腐败的味道，而产生口臭。因此，可有效去除口臭的口腔卫生保健品成为了热销产品。
目前市场上的口腔卫生保健品很多，如以木糖醇和薄荷为主要原料的口香糖，以田七、菊花等为主要原料的牙膏，虽然这些口香糖或牙膏能减少口腔中的病菌，降低牙齿的发病率，但没有抗炎镇痛作用，并且香味保持时间短。
沉香为瑞香科沉香属(Aquilaria)植物中含有树脂的木材，白木香(Aquilariasinensis)是我国沉香的唯一基源植物，主产于海南、广东等地。沉香为我国传统名贵中药，被誉为“药中黄金”。李时珍在《本草纲目》中记载：“沉香，气味辛，微温。主治：风水毒肿，去恶气；主心腹痛，霍乱中恶，邪鬼疰气，清人神；调中，补五脏，益精壮阳，暖腰膝，止转筋吐泻冷气，破症癣，冷风麻痹，骨节不任，风湿皮肤瘙痒，气痢；补脾胃，益气和神。治气逆喘急，大肠虚闭，小便气淋，男子精冷。”。沉香其味、苦，性微温，具行气止痛、温中止呕、纳气平喘等功效。此外，还作治疗精神疾病，如神经官能症、强迫症、精神分裂症和神经衰弱。同时，沉香具有镇静、降压、抗心律失常、抗心肌缺血和中枢神经系统抑制和抗菌等作用。沉香除作药用外，因其具有独特的芳香气味，也被大量用于熏香香料行业。沉香的气味非常复杂，如具有花香、奶香、蜜香、梅香、清凉、药味等复合气体。总的来说，沉香的香气分子非常稳定且不易挥发。近年来，沉香还被作为矫味剂添加到酒、茶叶、香烟中。因此，研发一种具有抗菌、抗炎、镇痛作用且香味持久的口腔保健品具有重要的现实意义。
发明内容
有鉴于此，本发明提供了一种中药组合物及其制备方法和口腔保健品。该中药组合物具有显著的抗菌、抗炎、镇痛作用，且香味持久。
为了实现上述发明目的，本发明提供以下技术方案：
本发明提供了一种中药组合物，由沉香、薄荷、三七、地胆草和甘草制成。
本发明组合物是在传统中药理论指导下，结合现代药理研究组方而成的。沉香具有镇静、降压、抗心律失常、抗心肌缺血和中枢神经系统抑制和抗菌等作用。沉香除作药用外，还具有独特的芳香气味，如具有花香、奶香、蜜香、梅香、清凉、药味等复合气体，而且沉香的香气分子非常稳定且不易挥发。薄荷含薄荷醇、薄荷酮，具有疏风散热、辟秽解毒之功效，可治疗咽喉肿痛、口疮和牙痛。三七具有止血散瘀、消肿定痛的功效，用于治疗外伤出血，痈肿疼痛。地胆草不但具有保肝、降血压、降血糖等活性，还有抗肿瘤、抗病毒、抗炎、抗菌等多种重要活性。甘草主治清热解毒、祛痰止咳、脘腹等。本发明将沉香、薄荷、三七、地胆草和甘草作为口腔保健品的主要功能成分，能有效地起到抗菌、抗炎、镇痛、香味持久的作用，减少口腔内的病菌，降低龋齿的发病率。
作为优选，以重量份计，包括：
在本发明提供的一实施例中，以重量份计，包括：
在本发明提供的另一实施例中，以重量份计，包括：
在本发明提供的另一实施例中，以重量份计，包括：
在本发明提供的另一实施例中，以重量份计，包括：
在本发明提供的另一实施例中，以重量份计，包括：
在本发明提供的另一实施例中，以重量份计，包括：
本发明提供了该中药组合物在制备具有抗菌、抗炎和/或镇痛功效的药物或保健品中的应用。
本发明还提供了该中药组合物的制备方法，包括：将沉香、薄荷、三七、地胆草和甘草5种原料药混合，加入水或乙醇水溶液进行回流提取，过滤，将滤液减压浓缩至稠膏，得到中药组合物。
作为优选，水或乙醇水溶液的用量为原料药总量的10～15倍体积。
在本发明提供的实施例中，水或乙醇水溶液的用量为原料药总量的10～12倍体积。
作为优选，回流提取的次数为2～3次，每次提取的时间为40～70min。
在本发明提供的实施例中，回流提取的次数为2次，每次提取的时间为60～70min。
作为优选，乙醇水溶液中乙醇的体积百分比为40％～90％。
在本发明提供的实施例中，乙醇水溶液中乙醇的体积百分比为60％～90％。
作为优选，减压浓缩的温度在60℃以下，稠膏在60℃下的相对密度为1.10～1.12。
在本发明提供的实施例中，减压浓缩的温度在35～50℃，稠膏在60℃下的相对密度为1.10～1.11。
本发明还提供了一种口腔保健品，包括本发明提供的中药组合物，以及药学或食品学上可接受的辅料。
作为优选，口腔保健品的剂型为口腔清新剂、口香糖、牙膏、牙凝胶、牙粉、漱口水或片剂。
本发明还提供了该口腔保健品的制备方法，包括：将本发明提供的中药组合物进行干燥，加入药学或食品学上可接受的辅料，制剂成型，得到口腔保健品。
本发明提供了一种中药组合物及其制备方法和口腔保健品。该中药组合物由沉香、薄荷、三七、地胆草和甘草制成。本发明具有如下优势：
1、本发明将沉香、薄荷、三七、地胆草和甘草作为中药组合物或口腔保健品的主要功能成分，能有效地起到抗菌、抗炎、镇痛、香味持久的作用，减少口腔内的病菌，降低龋齿的发病率，效果好于各中药单剂，与现有的西药效果相近；
2、本发明中药组合物只需将沉香等原料药在溶剂作用下，进行回流提取，再浓缩成膏状，即可获得中药组合物；再加入辅料成型即可得到口腔保健品；整个制作过程的条件简单，操作容易，且原料药易得。
具体实施方式
本发明公开了一种中药组合物及其制备方法和口腔保健品，本领域技术人员可以借鉴本文内容，适当改进工艺参数实现。特别需要指出的是，所有类似的替换和改动对本领域技术人员来说是显而易见的，它们都被视为包括在本发明。本发明的方法及应用已经通过较佳实施例进行了描述，相关人员明显能在不脱离本发明内容、精神和范围内对本文所述的方法和应用进行改动或适当变更与组合，来实现和应用本发明技术。
本发明提供的中药组合物及其制备方法和口腔保健品中所用原料药或辅料均可由市场购得。
下面结合实施例，进一步阐述本发明：
实施例1中药组合物的制备
取沉香50g、薄荷20g、三七30g、地胆草40g、甘草10g混合，加入12倍体积的水回流提取2次，每次60min。过滤，合并滤液；将滤液在40℃下，减压浓缩至相对密度为1.11(60℃)。
实施例2中药组合物的制备
称取沉香20g、薄荷50g、三七10g、地胆草40g、甘草10g混合，加入10倍体积的90％乙醇中回流提取2次，每次70min。过滤，合并滤液；将滤液在50℃下，减压浓缩至相对密度为1.10(60℃)。
实施例3中药组合物的制备
取沉香50g、薄荷40g、三七20g、地胆草10g、甘草40g混合，加入12倍体积的水回流提取2次，每次60min。过滤，合并滤液；将滤液在40℃下，减压浓缩至相对密度为1.11(60℃)。
实施例4中药组合物的制备
取沉香50g、薄荷30g、三七10g、地胆草20g、甘草30g混合，加入10倍体积的60％乙醇中回流提取2次，每次60min。过滤，合并滤液；将滤液在45℃下，减压浓缩至相对密度为1.11(60℃)，
实施例5中药组合物的制备
取沉香30g、薄荷10g、三七40g、地胆草30g、甘草20g混合，加入10倍体积的70％乙醇中回流提取2次，每次60min。过滤，合并滤液；将滤液在35℃下，减压浓缩至相对密度为1.10(60℃)。
试验例1本发明组合物的抗菌实验
分别取实施例1～5所制备的中药组合物浓缩液，将其稀释为50mg/ml。浓缩液抗金黄色葡萄球菌(Staphylococcus aureus)活性实验采用滤纸片琼脂扩散法测定。采用NA培养基培养，将S.aureus制成一定浓度的菌悬液(105～107cfu/mL)，用棉签将其均匀涂布于供试无菌平板，制成含菌平板。然后取样品溶液50μL分别滴加于灭菌滤纸片上(Φ＝6mm)，待溶剂挥干后将滤纸片贴于含菌平板上，每处理重复3次。然后37℃恒温培养。24h后观察结果，测量并记录抑菌圈直径。以万古霉素作为阳性对照。结果见表1。
表1本发明中药组合物对金黄色葡萄球菌的抑菌圈直径(mm，n＝3)
注：1.滤纸圆片直径为6mm。
2.万古霉素做阳性对照。
由上述试验结果表明，本发明方法制备的中药组合物对人体病原菌金黄色葡萄球菌表现出明显的抑制作用。
试验例2本发明组合物的抗炎实验
取昆明种小鼠120只，随机分为12组，每组10只，雌雄各半。阴性对照组给予等体积的蒸馏水，阳性对照为阿司匹林，5组给予实施例1～5所制备的浓缩液5组给予各原料药按实施例1方法制备的单剂，每次剂量为10g生药，每日1次，连续3天。于末次给药后1h，给小鼠右耳滴以二甲苯0.05ml/只，左耳作对照。15分钟后处死动物，用直径6cm的打孔器将双耳同部位摘下，在感量为1mg的精密分析天平上称重，以左耳和右耳片重之差计算各组肿胀度，并比较组间差异。
表2本发明组合物对小鼠耳廓肿胀的影响
注：﹡P<0.05。
结果如表2所示，本发明组合物能明显对抗二甲苯所致的小鼠耳廓肿胀，有较强的抗炎作用，效果好于单剂组。
试验例3本发明组合物的镇痛实验
小鼠分组及给药同试验例2，于末次给药后30min用浓度为0.7％的醋酸生理盐水0.1ml腹腔注射，观察15min内小鼠的扭体次数。结果见表3。
表3本发明组合物对小鼠致痛剂后的影响
| 组别 | 动物数 | 小鼠扭体次数 |
| 阴性对照组 | 10 | 52.4±6.1 |
| 实施例1 | 10 | 28.0±8.5﹡﹡ |
| 实施例2 | 10 | 29.6±6.7﹡﹡ |
| 实施例3 | 10 | 34.8±10.6﹡﹡ |
| 实施例4 | 10 | 34.2±8.0﹡﹡ |
| 实施例5 | 10 | 32.0±8.0﹡﹡ |
| 沉香单剂 | 10 | 36.8±7.0﹡﹡ |
| 薄荷单剂 | 10 | 38.5±5.1﹡﹡ |
| 三七单剂 | 10 | 36.5±6.5﹡﹡ |
| 地胆草单剂 | 10 | 36.0±3.0﹡﹡ |
| 甘草单剂 | 10 | 40.2±5.0﹡ |
| 阿司匹林 | 10 | 26.0±9.2﹡﹡ |
注：与阴性对照组比较，﹡﹡P<0.01，﹡P<0.05。
由表3可知，实施例1-5中药组合物治疗后小鼠的扭体次数与阴性对照组及单剂组比较组间差异，与阳性对照组的效果相近，试验结果表明本发明中药组合物可明显减少小鼠注射致痛剂后产生的扭体次数，具有明显的镇痛作用。
实施例6口腔清新剂的制备
取实施例1制得的中药组合物5wt％，食用乙醇10wt％，冰片2wt％，水余量，加热搅拌溶解混合。灌装，高压灭菌，装入喷雾瓶中，即得口腔清新剂。
实施例7口香糖的制备
按照以下重量比例称取原料：实施例2制得的中药组合物15％，木糖醇50％，胶基35％。按常规口香糖的制备工艺制作。
实施例8漱口水的制备
取实施例3制得的中药组合物5wt％，氟化钠0.01wt％，水余量。灌装，高压灭菌即得漱口水。
实施例9漱口片的制备
将实施例4制得的中药组合物喷雾干燥；加入羧甲淀粉钠4.0wt％，混匀，制成片剂。
实施例10牙膏的制备
取实施例5制得的中药组合物0.5wt％，甘油30wt％，羧甲基纤维素0.6wt％，羟乙基纤维素0.5wt％，木糖醇1wt％，碳酸氢钙50wt％，十二醇硫酸钠2.6wt％，水余量。将中药组合物、羧甲基纤维素和羟乙基纤维素分散于甘油中，将木糖醇溶于水中，两者混合均匀。加入碳酸氢钙和十二醇硫酸钠，混合研磨，捏合，真空脱气，灌装即得。
以上所述仅是本发明的优选实施方式，应当指出，对于本技术领域的普通技术人员来说，在不脱离本发明原理的前提下，还可以做出若干改进和润饰，这些改进和润饰也应视为本发明的保护范围。
Claims (10)
1.一种中药组合物，其特征在于，由沉香、薄荷、三七、地胆草和甘草制成。
2.根据权利要求1所述的中药组合物，其特征在于，以重量份计，包括：
3.如权利要求1或2所述中药组合物在制备具有抗菌、抗炎和/或镇痛功效的药物或保健品中的应用。
4.如权利要求1或2所述中药组合物的制备方法，其特征在于，包括：将沉香、薄荷、三七、地胆草和甘草5种原料药混合，加入水或乙醇水溶液进行回流提取，过滤，将滤液减压浓缩至稠膏，得到中药组合物。
5.根据权利要求4所述的制备方法，其特征在于，所述水或乙醇水溶液的用量为原料药总量的10～15倍体积。
6.根据权利要求4或5所述的制备方法，其特征在于，所述回流提取的次数为2～3次，每次提取的时间为40～70min。
7.根据权利要求4至6中任一项所述的制备方法，其特征在于，所述乙醇水溶液中乙醇的体积百分比为40％～90％。
8.根据权利要求4至7中任一项所述的制备方法，其特征在于，所述减压浓缩的温度在60℃以下，所述稠膏在60℃下的相对密度为1.10～1.12。
9.一种口腔保健品，其特征在于，包括权利要求1或2所述中药组合物，以及药学或食品学上可接受的辅料。
10.根据权利要求9所述的口腔保健品，其特征在于，所述口腔保健品的剂型为口腔清新剂、口香糖、牙膏、牙凝胶、牙粉、漱口水或片剂。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610894244.8A CN106309746A (zh) | 2016-10-13 | 2016-10-13 | 一种中药组合物及其制备方法和口腔保健品 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610894244.8A CN106309746A (zh) | 2016-10-13 | 2016-10-13 | 一种中药组合物及其制备方法和口腔保健品 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106309746A true CN106309746A (zh) | 2017-01-11 |
Family
ID=57820445
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610894244.8A Pending CN106309746A (zh) | 2016-10-13 | 2016-10-13 | 一种中药组合物及其制备方法和口腔保健品 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106309746A (zh) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108524346A (zh) * | 2017-03-03 | 2018-09-14 | 深圳曦元生物科技有限公司 | 一种速效美白洁牙粉 |
| CN109394599A (zh) * | 2017-08-15 | 2019-03-01 | 朱丽珍 | 一种牙粉 |
| CN114288220A (zh) * | 2022-01-05 | 2022-04-08 | 青岛奕德堂海洋生物科技发展有限公司 | 一种沉香含漱抑菌液 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102125513A (zh) * | 2011-02-25 | 2011-07-20 | 海南黎药堂生物科技开发有限公司 | 口腔保健品及其制备方法 |
-
2016
- 2016-10-13 CN CN201610894244.8A patent/CN106309746A/zh active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102125513A (zh) * | 2011-02-25 | 2011-07-20 | 海南黎药堂生物科技开发有限公司 | 口腔保健品及其制备方法 |
Non-Patent Citations (2)
| Title |
|---|
| 张仁俊等主编: "《实用眼科药物学》", 30 September 2015, 人民军医出版社 * |
| 谢文英编著: "《名医珍藏百草良方》", 31 May 2014, 陕西科学技术出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108524346A (zh) * | 2017-03-03 | 2018-09-14 | 深圳曦元生物科技有限公司 | 一种速效美白洁牙粉 |
| CN109394599A (zh) * | 2017-08-15 | 2019-03-01 | 朱丽珍 | 一种牙粉 |
| CN114288220A (zh) * | 2022-01-05 | 2022-04-08 | 青岛奕德堂海洋生物科技发展有限公司 | 一种沉香含漱抑菌液 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100420432C (zh) | 漱口液及制备方法 | |
| CN104666621B (zh) | 一种具有止血、消炎和抑菌作用的中药组合物及含其牙膏 | |
| CN102139030B (zh) | 一种治疗牙龈炎的口腔中药制剂及其制备方法 | |
| CN102125513B (zh) | 口腔保健品及其制备方法 | |
| CN108272862B (zh) | 一种蒲地蓝口腔喷雾剂及其制备方法 | |
| CN112263606A (zh) | 一种中药含漱液及其制备方法 | |
| CN108815232A (zh) | 一种草本抗菌液 | |
| CN102940595A (zh) | 一种具有抗菌消炎脱臭的漱口液及其制备方法和用途 | |
| CN110384725B (zh) | 一种用于调整口腔菌群的中药组合及其活性提取物的制备 | |
| CN113332244A (zh) | 一种抗病毒口腔喷剂及制备方法 | |
| CN111759885A (zh) | 一种苦参组合物、苦参凝胶及其制备方法 | |
| CN106309746A (zh) | 一种中药组合物及其制备方法和口腔保健品 | |
| CN104258455B (zh) | 一种医用生物抗菌敷料及其制备方法 | |
| CN103933275A (zh) | 一种抗菌消毒药剂及其制作方法 | |
| CN106309325A (zh) | 一种抗菌消炎漱口水及其制备方法 | |
| CN104857413A (zh) | 一种去除口腔异味的中药组合物及其制备方法 | |
| CN114306526B (zh) | 一种复方苦丁茶中药提取物及其在制备沐浴露或洗手液中的应用 | |
| CN114053331B (zh) | 一种口腔抑菌组合物、口腔抑菌液、应用及制备方法 | |
| CN104784534B (zh) | 一种预防手足口病用洗手液 | |
| CN111358927B (zh) | 蒲姜药物组合物及其应用 | |
| CN114246893B (zh) | 一种治疗色素脱失的中药外用制剂及其制备方法和应用 | |
| CN107362184A (zh) | 赶黄草及其提取物在制备治疗或/和预防牙龈炎的口腔用药物中的用途 | |
| CN105769718A (zh) | 一种用于清洁口腔的中药漱口水及其制备方法 | |
| CN105726681A (zh) | 一种治疗奶牛子宫内膜炎的注射液及其制备方法 | |
| CN104906379A (zh) | 一种治疗大疱性脓包疮的中药软膏及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20170510 Address after: Qiongshan District Fengxiang road 571100 Hainan city of Haikou province No. 168 River Bay Villa B2-3/4 Applicant after: Hainan ancient Fang Fang Xiang Technology Co., Ltd. Address before: 571001 No. 4, Longhua, Haikou District, Hainan, Xueyuan Road Applicant before: Yang Jinling |
|
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170111 |