WO2018054265A1 - Composition d'emballage de composition lipidique hydrophile, son procédé de préparation et de mélange et ses applications - Google Patents

Composition d'emballage de composition lipidique hydrophile, son procédé de préparation et de mélange et ses applications Download PDF

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Publication number
WO2018054265A1
WO2018054265A1 PCT/CN2017/101851 CN2017101851W WO2018054265A1 WO 2018054265 A1 WO2018054265 A1 WO 2018054265A1 CN 2017101851 W CN2017101851 W CN 2017101851W WO 2018054265 A1 WO2018054265 A1 WO 2018054265A1
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Prior art keywords
liquid
lipid composition
fat
water
acid
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PCT/CN2017/101851
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English (en)
Chinese (zh)
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雷凡琦
王保红
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张碧婷
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/005—Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/005—Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
    • A23D7/0053—Compositions other than spreads
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/01—Other fatty acid esters, e.g. phosphatides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/01—Other fatty acid esters, e.g. phosphatides
    • A23D7/011—Compositions other than spreads
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/02—Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by the production or working-up
    • A23D7/04—Working-up
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/06—Preservation of finished products
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
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    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
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    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
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    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
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    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
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    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
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    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
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    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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Definitions

  • the present invention relates to a health product composition, in particular to a packaging composition of a hydrophilic lipid composition, a process for the preparation thereof, its use and application.
  • the health product composition according to the present invention includes a medicine, a special medical use formula food, a health food, a nutraceutical food, a cosmetic, etc., and specifically a composition containing an emulsifier and a liquid fat which does not contain water.
  • lipids including unsaturated fatty acids are completely incompatible with water.
  • the use of healthy nutrients is used at the same time.
  • the prior art is to prepare a lipid substance and a water-based liquid for use as an emulsion for a patient or a special population.
  • this pre-prepared emulsion maintains the stability and elongation of the emulsion.
  • a large amount or even an excess of emulsifier is added, and in order to maintain the stability of unsaturated fatty acids, a large amount of antioxidants, preservatives, and alkaline compounds such as sodium hydroxide are used to adjust the opacity.
  • the pH of the liquid which is not conducive to the oral absorption of fatty acids, and even poses a health hazard; in addition, unsaturated fatty acids and esters, such as linolenic acid, linoleic acid, oleic acid, arachidonic acid, conjugated linoleum Acid, conjugated linoleic acid glyceride, DHA, EPA, nervonic acid, etc. in the aqueous mixture, it is easy to oxidize and degrade, especially at temperatures above 40 °C, accelerate degradation, build Loss of a large number of unsaturated fatty acids, and seriously affect the quality and safety of the composition.
  • lipids especially unsaturated fatty acids, are very greasy and unacceptable when consumed directly; therefore, the prior art takes oral intake by making unsaturated fatty acids into soft capsules, which is not conducive to oral taking.
  • the convenience of access is also not conducive to large doses of oral intake, but also is not conducive to oral absorption.
  • Chinese Patent Publication Nos. CN104397702A, CN104490773A, and CN104397706A disclose an emulsion composition containing a phospholipid, another fat-soluble substance, and water, which forms a uniform emulsion of a fat-soluble substance and water by a high-speed stirring emulsification and a homogeneous processing process. Conducive to consumption and absorption.
  • the fat-soluble substance of unsaturated fatty acid is easily oxidized and degraded in an aqueous mixed solution, especially at a temperature above 40 ° C, which accelerates degradation, resulting in a large loss of unsaturated fatty acids, and is severe. Affect the quality and safety of the composition.
  • a non-aqueous lipid composition having good stability but a non-aqueous lipid composition is oily, completely incompatible with water and floating on the water surface, and stirring or shaking does not allow the lipid composition to The water is evenly mixed, which is extremely disadvantageous for the preparation of the lipid composition.
  • the scope of use thereof is severely limited, especially for the need to mix the lipid composition with the water agent uniformly, or need to It is very difficult to formulate a lipid composition into a nutrient food/special medical use formula which can be orally administered as a homogenized meal; and it is also necessary to satisfy the user's quick and easy formulation with a liquid agent, and to prepare a good mixture. It is an emulsion and is not easily visible to the naked eye, which is beneficial for consumption and use.
  • liquid fats that do not contain water should be satisfied when they are formulated into a product that is easy to be orally ingested with water-based liquids, especially in the practical application or clinical use of nutritional foods, special medical formulas, medicines, etc.
  • the emulsion formed by the water-based liquid has good stability and is not prone to obvious delamination, for example, no visible delamination occurs in at least 1 minute, so that the user has a longer drinking period. Or the time of oral intake;
  • the formed emulsion can form a uniform emulsion after slight swaying after standing to facilitate intermittent drinking or oral ingestion by the user.
  • the prior art cannot satisfy the above four conditions, and generally the use of the non-aqueous lipid composition into a soft capsule preparation is used, which greatly limits the consumer or the patient.
  • the demand for intake for example, for patients who cannot be swallowed and need enteral nutrition support, this soft capsule preparation cannot be ingested by the tube, and also limits the oral absorption and utilization of the fat-soluble substance.
  • An object of the present invention is to provide a lipid composition which has excellent hydrophilicity and which is rapidly dissolved in a water-based liquid to form an emulsion, and a method of blending the same.
  • the lipid composition has excellent hydrophilicity, which not only ensures the product quality of the lipid composition in production, storage and transportation, and shelf life, but also facilitates mixing and dissolving with the water-based liquid during use, and is convenient and quick. Use.
  • the present invention provides a hydrophilic lipid composition containing a liquid fat and an emulsifier, which is mixed with a water-based liquid and then shaken to form an emulsion. Further, the present invention also provides a packaging composition thereof, a preparation method, its formulation use and application.
  • the liquid fat of the present invention is defined as a fatty acid or fat which exhibits a liquid state at normal temperature and pressure, and includes a saturated or unsaturated fatty acid, a saturated or unsaturated fat, a triglyceride of a saturated or unsaturated fatty acid, a saturated or The diglyceride of the unsaturated fatty acid, for example, but not limited to, oleic acid, linoleic acid, linolenic acid, medium chain triglyceride, diglyceride, medium long chain fatty acid, and the like.
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, a fat-soluble substance A and a fat-soluble substance B, the emulsifier being selected from one or more of the following: phospholipids, sucrose fatty acid esters, single and double Glycerol fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty acid glyceride, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Division
  • the fat-soluble substance A is selected from the following one Or a variety of substances: oleic acid, linoleic acid, linolenic acid, medium chain triglycerides, diglycerides, medium and long
  • the linolenic acid includes ⁇ -linen Acid or gamma-linolenic acid, the medium long chain fatty acid comprising a medium chain fatty acid or a long chain fatty acid.
  • the fat-soluble substance A and the fat-soluble substance B of the present invention are both fatty acids or fat-soluble substances, usually extracted from vegetable oil or animal oil, or further extracted from vegetable oil or animal oil (such as fish oil, krill oil).
  • a resynthesized compound or fat for example, lecithin is extracted from soybean oil or egg yolk, and phosphatidylserine is produced by using lecithin and L-serine as a raw material, and is purified by a phospholipase conversion reaction;
  • Phytosterols include ⁇ -sitosterol, campesterol, stigmasterol, etc. extracted from soybean oil, rapeseed oil, corn oil, sunflower oil, and tallow oil;
  • the fat-soluble substance A or the fat-soluble substance B of the present invention is usually present in the oil and fat in a certain amount, and the fat-soluble substance A or the fat-soluble substance B of the present invention may also contain the above-mentioned A vegetable oil or animal oil of the fat-soluble substance A or the fat-soluble substance B, or a compound or fat which is further synthesized or fermented after being extracted from vegetable oil or animal oil is used in the present invention.
  • perilla seed oil, linseed oil, peony seed oil, cane fruit oil or eucommia seed oil having an ⁇ -linolenic acid content of more than 30% is used as a donor of ⁇ -linolenic acid, and is applied to the present invention
  • ⁇ -linolenic acid ⁇ -linolenic acid oil having a content of more than 8% is used as a donor of ⁇ -linolenic acid, and is applied to the present invention
  • medium-long-chain fatty acid edible oil contains more than 11% of medium-chain fatty acids and more than 10% of long-chain fatty acids
  • medium-long-chain fatty acid edible oil can be used as a medium-long-chain fatty acid, medium-chain fatty acid or long-chain fatty acid.
  • ingot ore oil having a lingonic acid content of 3% to 8% or a shark oil as a donor of nervonic acid is used in the present invention.
  • DHA algal oil having a DHA content of 3% to 6% is used as a donor of DHA, and is applied to the present invention
  • a fish oil or fish oil extract having a DHA content of 3% to 15% is used as a donor of DHA, and is applied to the present invention
  • Krill oil having a DHA content of more than 3% is used as a donor of DHA, and is applied to the present invention
  • soybean phospholipids for example, soybean phospholipids, krill oil, soy lecithin, egg yolk phospholipids, egg yolk lecithin with a total phospholipid content greater than 35% As a donor of phospholipids, it is used in the present invention.
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, a fat-soluble substance A, and a fat-soluble substance B, the emulsifier being selected from one or more of the following: a phospholipid, a sucrose fatty acid ester, Mono, diglycerin fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty acid glyceride, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80; wherein the content of the emulsifier is 0.05% to 8% by weight, preferably the content of the emulsifier is 0.1% to 6% by weight; the fat-soluble substance A is selected from the group consisting of Medium chain triglyceride and one or more of the following: oleic acid, linoleic acid, alpha-linolenic acid, gamma
  • the fat-soluble substance B is selected from one or more of the following substances: nervonic acid, DHA, EPA, peanut Tetraenoic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol,
  • the phosphatidylcholine wherein the content of the fat-soluble substance B is 0 to 30% by weight, preferably the content of the fat-soluble substance B is 0.01% to 30% by weight;
  • the medium-long chain fatty acid includes a medium chain Fatty acid or long-chain fatty acid, the emulsifier also includes various types, specifications, degree of polymerization, degree of esterification, mono/diester, or monomer components thereof, including lecithin, phosphatidylethanolamine, Phosphatidylinositol or phosphati
  • the content of the fat-soluble substance B is 0.01% to 30% by weight, preferably the content of the fat-soluble substance B is 0.05% to 25% by weight, and preferably the content of the fat-soluble substance B is 0.01 by weight. %, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4% 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1 %, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5%, 5.1%, 5.2%, 5.3%,
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, a fat-soluble substance A, and a fat-soluble substance B, the emulsifier being selected from one or more of the following: a phospholipid, a sucrose fatty acid ester, Mono, diglycerin fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty acid glyceride, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80, wherein the content of the emulsifier is 0.05% to 8% by weight;
  • the fat-soluble substance A is selected from the group consisting of linolenic acid and one or more of the following substances: oleic acid, sub Oleic acid, medium chain triglyceride, diglyceride, medium long chain fatty acid, wherein the content of linolenic acid in the
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, a fat-soluble substance A, and a fat-soluble substance B, the emulsifier being selected from one or more of the following: a phospholipid, a sucrose fatty acid ester, Mono, diglycerin fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty acid glyceride, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80, wherein the content of the emulsifier is 0.05% to 8% by weight;
  • the fat-soluble substance A is selected from the group consisting of linoleic acid and one or more of the following substances: oleic acid, ⁇ -linolenic acid, ⁇ -linolenic acid, medium-chain triglyceride, diglyceride, medium-long-chain
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, a fat-soluble substance A, and a fat-soluble substance B, the emulsifier being selected from one or more of the following: a phospholipid, a sucrose fatty acid ester, Mono, diglycerin fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty acid glyceride, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80, wherein the content of the emulsifier is 0.05% to 8% by weight;
  • the fat-soluble substance A is selected from the group consisting of oleic acid and one or more of the following substances: linoleic acid, ⁇ -linolenic acid, ⁇ -linolenic acid, medium chain triglyceride, diglyceride, medium long chain fatty acid,
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, a medium chain triglyceride, and a fat-soluble substance A, which is selected from the group consisting of oleic acid, linoleic acid, and ⁇ -linen.
  • an emulsifier a medium chain triglyceride
  • a fat-soluble substance A which is selected from the group consisting of oleic acid, linoleic acid, and ⁇ -linen.
  • the ratio is preferably 0.05% to 8%, preferably the content of the emulsifier is 0.1% to 6% by weight, and most preferably the emulsifier is 0.3% to 2.5% by weight
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, a medium chain triglyceride, and a fat-soluble substance B, the fat-soluble substance B being selected from the group consisting of nervonic acid, DHA, EPA, and arafflene.
  • the weight ratio is 0.1% to 6%, and the content of the fat-soluble substance B is 0.01% to 30% by weight, preferably the fat-soluble substance B The content is 0.05% to 25% by weight, and preferably the content of the fat-soluble substance B is 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09% by weight.
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, a nervonic acid, and a fat-soluble substance A, wherein the fat-soluble substance A is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and medium chain glycerin One or more of an ester, a medium long chain fatty acid, and a diglyceride, the content of the fat-soluble substance A is more than 45% by weight, and the content of the emulsifier is 0.05% to 8% by weight, preferably an emulsifier.
  • the fat-soluble substance A is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and medium chain glycerin
  • the content of the fat-soluble substance A is more than 45% by weight
  • the content of the emulsifier is 0.05% to 8% by weight, preferably an emulsifier.
  • the content is 0.1% to 6% by weight, and the content of the nerve acid is 0.01% to 30% by weight, and preferably the content of the nerve acid is 0.01%, 0.02%, 0.03%, 0.04% by weight.
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, DHA, and a fat-soluble substance A, which is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and medium chain triglyceride.
  • a fat-soluble substance A which is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and medium chain triglyceride.
  • the content of the fat-soluble substance A is more than 45% by weight
  • the content of the emulsifier is 0.05% to 8% by weight, preferably an emulsifier.
  • the content is 0.1% to 6% by weight
  • the content of DHA is 0.01% to 30% by weight, and preferably the content of DHA is 0.04% to 25% by weight.
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, EPA, and a fat-soluble substance A, which is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and medium chain triglyceride.
  • an emulsifier EPA
  • a fat-soluble substance A which is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and medium chain triglyceride.
  • the content of the fat-soluble substance A is more than 45% by weight
  • the content of the emulsifier is 0.05% to 8% by weight, preferably an emulsifier.
  • the content is 0.1% to 6% by weight, and the EPA content is 0.01% to 30% by weight.
  • the content of EPA is selected to be 0.04% to 25% by weight.
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, arachidonic acid, and a fat-soluble substance A, wherein the fat-soluble substance A is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and medium chain.
  • the content of the fat-soluble substance A is more than 45% by weight, and the content of the emulsifier is 0.05% to 8% by weight, preferably The content of the emulsifier is 0.1% to 6% by weight, the content of arachidonic acid is 0.01% to 30% by weight, and the content of arachidonic acid is preferably 0.04% to 25% by weight.
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, vitamin E, and a fat-soluble substance A, wherein the fat-soluble substance A is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and medium chain glycerin One or more of an ester, a medium long chain fatty acid, and a diglyceride, the content of the fat-soluble substance A is more than 45% by weight, and the content of the emulsifier is 0.05% to 8% by weight, preferably an emulsifier.
  • the content is 0.1% to 6% by weight, and the content of vitamin E is 0.01% to 30% by weight, and preferably the content of vitamin E is 0.04% to 25% by weight.
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, a conjugated linoleic acid, and a fat-soluble substance A, wherein the fat-soluble substance A is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and the like.
  • the fat-soluble substance A is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and the like.
  • One or more of chain triglyceride, medium long chain fatty acid, and diglyceride the content of the fat-soluble substance A is more than 45% by weight, and the content of the emulsifier is 0.05% to 8% by weight.
  • the content of the emulsifier is 0.1% to 6% by weight
  • the content of the conjugated linoleic acid is 0.01% to 25% by weight
  • the content of the conjugated linoleic acid is preferably 0.04% by weight. 20%.
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, a conjugated linoleic acid glyceride, and a fat-soluble substance A, which is selected from the group consisting of oleic acid, linoleic acid, and linolenic acid.
  • an emulsifier a conjugated linoleic acid glyceride
  • a fat-soluble substance A which is selected from the group consisting of oleic acid, linoleic acid, and linolenic acid.
  • One or more of medium chain triglyceride, medium long chain fatty acid, and diglyceride the content of the fat-soluble substance A is more than 45% by weight, and the content of the emulsifier is 0.05% to 8 by weight.
  • the content of the emulsifier is from 0.1% to 6% by weight
  • the content of the conjugated linoleic acid glyceride is from 0.01% to 25% by weight, preferably the content of the conjugated linoleic acid glyceride is by weight.
  • the ratio is 0.04% to 20%.
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, phosphatidylserine, and a fat-soluble substance A, which is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and medium chain glycerin.
  • a triester, a medium long chain fatty acid, and a diglyceride the content of the fat-soluble substance A is more than 45% by weight
  • the content of the emulsifier is 0.05% to 8% by weight, preferably emulsified.
  • the content of the agent is from 0.1% to 6% by weight
  • the content of phosphatidylserine is from 0.01% to 30% by weight
  • the content of phosphatidylserine is preferably from 0.04% to 25% by weight.
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, polyene phosphatidylcholine, and a fat-soluble substance A, wherein the fat-soluble substance A is selected from the group consisting of oleic acid, linoleic acid, and linolenic acid.
  • the fat-soluble substance A is selected from the group consisting of oleic acid, linoleic acid, and linolenic acid.
  • the content of the emulsifier is 0.1% to 6% by weight, and the content of polyene phosphatidylcholine is 0.01% to 25% by weight, preferably the content of polyene phosphatidylcholine is by weight. 0.04% to 25%.
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, phytosterol, and a fat-soluble substance A
  • the fat-soluble substance A is selected from one or more of oleic acid, linoleic acid, linolenic acid, medium chain triglyceride, medium long chain fatty acid, and diglyceride, and the content of the fat-soluble substance A is in terms of weight ratio. More than 45%, the content of the emulsifier is 0.05% to 8% by weight, preferably the content of the emulsifier is 0.1% to 6% by weight, and the content of phytosterol is 0.01% to 30% by weight. Preferably, the content of phytosterol is from 0.04% to 25% by weight.
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, a phytosterol ester, and a fat-soluble substance A, which is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and medium chain glycerin.
  • a triester, a medium long chain fatty acid, and a diglyceride the content of the fat-soluble substance A is more than 45% by weight
  • the content of the emulsifier is 0.05% to 8% by weight, preferably emulsified.
  • the content of the agent is from 0.1% to 6% by weight
  • the content of the phytosterol ester is from 0.01% to 30% by weight, preferably from 0.05% to 26% by weight of the phytosterol ester.
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, a plant stanol ester, and a fat-soluble substance A, wherein the fat-soluble substance A is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and the like.
  • the fat-soluble substance A is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and the like.
  • One or more of chain triglyceride, medium long chain fatty acid, and diglyceride the content of the fat-soluble substance A is more than 45% by weight, and the content of the emulsifier is 0.05% to 8% by weight.
  • the content of the emulsifier is from 0.1% to 6% by weight, and the content of the plant stanol ester is from 0.01% to 30% by weight, preferably the content of the plant stanol ester is 0.04% by weight. 25%.
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising linolenic acid, an emulsifier, and a fat-soluble substance B, wherein the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, arachidonic acid, and vitamin E.
  • the linolenic acid includes ⁇ -linolenic acid or ⁇ -linolenic acid, wherein the content of linolenic acid is 45% to 99.5% by weight, and the content of the emulsifier is 0.05% by weight.
  • the content of the emulsifier is 0.3% to 2.5% by weight
  • the content of the fat-soluble substance B is 0.01% to 30% by weight, preferably the content of the fat-soluble substance B is 0.05% by weight.
  • the content of the fat-soluble substance B is 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.2%, 0.3 by weight.
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising linoleic acid, an emulsifier, and a fat-soluble substance B, wherein the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, and vitamins.
  • A vitamin D, conjugated linoleic acid, One or more of conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidylcholine, wherein linoleic acid is present
  • the weight ratio is 45% to 99%
  • the content of the emulsifier is 0.05% to 8% by weight, preferably the content of the emulsifier is 0.3% to 2.5% by weight
  • the content of the fat-soluble substance B is by weight.
  • the ratio of the fat-soluble substance B is preferably 0.04% to 25% by weight, and preferably the content of the fat-soluble substance B is 0.06% to 23% by weight.
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising oleic acid, an emulsifier, and a fat-soluble substance B, wherein the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, and vitamin A.
  • vitamin D conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidylcholine Or a plurality of, wherein the content of oleic acid is 45% to 99% by weight, the content of the emulsifier is 0.05% to 8% by weight, and preferably the content of the emulsifier is 0.3% to 2.5% by weight.
  • the content of the fat-soluble substance B is 0.01% to 30% by weight, and preferably the content of the fat-soluble substance B is 0.05% to 20% by weight.
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising medium chain triglyceride, an emulsifier, and a fat-soluble substance B, wherein the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, arachidonic acid, and vitamin E.
  • vitamin A vitamin D
  • conjugated linoleic acid conjugated linoleic acid glyceride
  • phosphatidylserine phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidylcholine
  • the content of the medium chain triglyceride is 40% to 99.5% by weight
  • the content of the emulsifier is 0.05% to 8% by weight
  • the content of the emulsifier is by weight
  • the content of the fat-soluble substance B is from 0.01% to 30% by weight, and the content of the fat-soluble substance B is preferably from 0.05% to 25% by weight.
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising a diglyceride, an emulsifier, and a fat-soluble substance B, wherein the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, and vitamins.
  • A vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidylcholine
  • the content of the diglyceride is 45% to 99% by weight
  • the content of the emulsifier is 0.05% to 8% by weight
  • the content of the emulsifier is preferably 0.3% by weight.
  • the content of the fat-soluble substance B is 0.01% to 30% by weight, and preferably the content of the fat-soluble substance B is 0.05% to 20% by weight.
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising a medium long chain fatty acid, an emulsifier, and a fat soluble substance B
  • the fat soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, Vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidylcholine
  • the content of the medium long chain fatty acid is 45% to 99% by weight
  • the content of the emulsifier is 0.05% to 8% by weight, and preferably the content of the emulsifier is 0.3 by weight.
  • % to 2.5% the content of the fat-soluble substance B is 0.01% to 30% by weight, and the content of the
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising oleic acid, linoleic acid, an emulsifier, and a fat-soluble substance B
  • the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol One or more of ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidylcholine, wherein the total content of oleic acid and linoleic acid is 45% to 99% by weight, emulsifier The content is 0.05% to 8% by weight, preferably the content of the emulsifier is 0.1% to 6% by weight, and the content of the fat-soluble substance B is 0.01%
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising linolenic acid, linoleic acid, an emulsifier, and a fat-soluble substance B, wherein the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, arachidonic acid, and vitamins.
  • E vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidylcholine
  • the total content of linolenic acid and linoleic acid is 45% to 99% by weight
  • the content of the emulsifier is 0.05% to 8% by weight
  • the content of the emulsifier is The weight ratio is from 0.1% to 6%
  • the content of the fat-soluble substance B is from 0.01% to 30% by weight, and preferably the content of the fat-soluble substance B is from 0.05% to 20% by weight.
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising linolenic acid, medium chain triglyceride, emulsifier, fat-soluble substance B, and the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, and arachidonic acid.
  • vitamin E vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidyl One or more of choline, wherein the total content of linolenic acid and medium chain triglyceride is 45% to 99% by weight, and the content of the emulsifier is 0.05% to 8% by weight, preferably emulsified
  • the content of the agent is from 0.1% to 6% by weight, and the content of the fat-soluble substance B is from 0.01% to 30% by weight, and preferably the content of the fat-soluble substance B is from 0.05% to 20% by weight.
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising linoleic acid, medium chain triglyceride, emulsifier, fat-soluble substance B, and the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, and arafflene.
  • Acid vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phospholipid
  • choline wherein the total content of linoleic acid and medium chain triglyceride is 45% to 99% by weight, and the content of emulsifier is 0.05% to 8% by weight.
  • the content of the emulsifier is 0.1% to 6% by weight
  • the content of the fat-soluble substance B is 0.01% to 30% by weight
  • the content of the fat-soluble substance B is 0.05% to 20% by weight.
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising medium chain triglyceride, linoleic acid, linolenic acid, an emulsifier, and a fat-soluble substance B
  • the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, Arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol,
  • One or more of polyene phosphatidylcholines wherein the total content of medium chain triglyceride, linoleic acid and linolenic acid is 45% to 99% by weight, and the content of emulsifier is by weight 0.05% to 8%, preferably the content of the emul
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising medium chain triglyceride, linolenic acid, linoleic acid, oleic acid, emulsifier, fat-soluble substance B, and the fat-soluble substance B is selected from the group consisting of nervonic acid and DHA.
  • EPA arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fat
  • an alkanol or a polyene phosphatidylcholine wherein the total content of medium chain triglyceride, linolenic acid, linoleic acid and oleic acid is 45% to 99% by weight, and the emulsifier is The content is 0.05% to 8% by weight, preferably the content of the emulsifier is 0.1% to 6% by weight, and the content of the fat-soluble substance B is 0.01% to 30% by weight, preferably the fat-soluble substance B. The content is 0.05% to 20% by weight.
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising medium chain triglyceride, medium long chain fatty acid, emulsifier, fat soluble substance B, and the fat soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, and peanut.
  • Acrylic acid vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene
  • phosphatidylcholines wherein the total content of medium chain triglyceride and medium long chain fatty acid is 45% to 99% by weight, and the content of emulsifier is 0.05% to 8 by weight.
  • % preferably, the content of the emulsifier is 0.1% to 6% by weight, the content of the fat-soluble substance B is 0.01% to 30% by weight, and the content of the fat-soluble substance B is preferably 0.05% by weight. 20%.
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising medium chain triglyceride, diglyceride, emulsifier, fat-soluble substance B, and the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, and arafflene.
  • Acid vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phospholipid
  • choline wherein the total content of medium chain triglyceride and diglyceride is 45% to 99% by weight, and the content of emulsifier is 0.05% to 8% by weight.
  • the content of the emulsifier is preferably from 0.1% to 6% by weight, and the content of the fat-soluble substance B is from 0.01% to 30% by weight.
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising linolenic acid, diglyceride, an emulsifier, and a fat-soluble substance B, wherein the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, arachidonic acid, and vitamins.
  • E vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidylcholine
  • the total content of linolenic acid and diglyceride is 45% to 99% by weight
  • the content of the emulsifier is 0.05% to 8% by weight
  • the content of the emulsifier is The weight ratio is from 0.1% to 6%
  • the content of the fat-soluble substance B is from 0.01% to 30% by weight, and preferably the content of the fat-soluble substance B is from 0.05% to 20% by weight.
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising diglyceride, linoleic acid, an emulsifier, and a fat-soluble substance B
  • the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, arachidonic acid, Vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidylcholine
  • One or more of the bases wherein the total content of the diglyceride and the linoleic acid is 45% to 99% by weight, and the content of the emulsifier is 0.05% to 8% by weight, preferably an emulsifier Content by weight
  • the content of the fat-soluble substance B is from 0.01% to
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising diglyceride, linoleic acid, linolenic acid, an emulsifier, and a fat-soluble substance B, wherein the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, and peanut.
  • Acrylic acid vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene
  • phosphatidylcholine wherein the total content of diglyceride, linoleic acid and linolenic acid is 45% to 99% by weight, and the content of emulsifier is 0.05% to 8 by weight.
  • % preferably, the content of the emulsifier is 0.1% to 6% by weight, the content of the fat-soluble substance B is 0.01% to 30% by weight, and the content of the fat-soluble substance B is preferably 0.05% by weight. 20%.
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising a medium long chain fatty acid, a diglyceride, an emulsifier, a fat soluble substance B, and the fat soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, and arachidonic acid.
  • vitamin E vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidyl One or more of choline, wherein the total content of the medium long chain fatty acid and the diglyceride is 45% to 99% by weight, and the content of the emulsifier is 0.05% to 8% by weight, preferably emulsified.
  • the content of the agent is from 0.1% to 6% by weight, and the content of the fat-soluble substance B is from 0.01% to 30% by weight, and preferably the content of the fat-soluble substance B is from 0.05% to 20% by weight.
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising linolenic acid, a medium long chain fatty acid, an emulsifier, and a fat soluble substance B
  • the fat soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, arachidonic acid, Vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidylcholine
  • the bases wherein the total content of the linolenic acid and the medium long-chain fatty acid is 45% to 99% by weight, and the content of the emulsifier is 0.05% to 8% by weight, preferably an emulsifier The content is 0.1% to 6% by weight, and the content of the fat
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising linoleic acid, a medium long chain fatty acid, an emulsifier, a fat soluble substance B, and the fat soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, and arachidonic acid.
  • vitamin E vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidyl
  • choline wherein the total content of linoleic acid and medium long-chain fatty acid is 45% to 99% by weight, and the content of emulsifier is 0.05% to 8% by weight, preferably emulsified
  • the content of the agent is from 0.1% to 6% by weight, and the content of the fat-soluble substance B is from 0.01% to 30% by weight, and preferably the content of the fat-soluble substance B is from 0.05% to 20% by weight.
  • the emulsifier of the present invention is selected from one or more of the following: phospholipids, sucrose fatty acid esters, mono-, diglycerin fatty acid esters, polyglycerol fatty acid esters, propylene glycol fatty acid esters, lactic acid fatty acid glycerides, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80; the content of emulsifier is by weight 0.05% to 8%, preferably the content of the emulsifier is 0.1% to 6% by weight;
  • the content of the emulsifier is 0.07% to 7% by weight
  • the content of the emulsifier is 0.1% to 6% by weight;
  • the content of the emulsifier is 0.2% to 5% by weight
  • the content of the emulsifier is 0.3% to 4% by weight;
  • the content of the emulsifier is 0.4% to 3.5% by weight
  • the content of the emulsifier is 0.5% to 3% by weight
  • the content of the emulsifier is 0.6% to 2.5% by weight
  • the content of the emulsifier is 0.75% to 2% by weight;
  • the content of the emulsifier is 0.8% to 1.8% by weight
  • the content of the emulsifier is 0.85% to 1.7% by weight
  • the content of the emulsifier is 0.9% to 1.6% by weight
  • the content of the emulsifier is 0.95% to 1.5% by weight
  • the content of the emulsifier is 1.0% to 1.4% by weight;
  • the content of the emulsifier is 0.4% to 1.6% by weight;
  • the content of the emulsifier is 0.5% to 1.5% by weight
  • the content of the emulsifier is 0.6% to 1.4% by weight;
  • the content of the emulsifier is 0.7% to 1.3% by weight;
  • the content of the emulsifier is from 0.8% to 1.2% by weight.
  • the emulsifier further includes various types, specifications, degrees of polymerization, degree of esterification, mono/diester, or monomer components thereof.
  • the phospholipids include, but are not limited to, lecithin, phosphatidylethanolamine, phosphatidylinositol or phosphatidylglycerol.
  • the content of lecithin (ie, phosphatidylcholine) in the phospholipid is greater than 40%, preferably The content of lecithin in the phospholipid is greater than 50%; preferably, the content of lecithin in the phospholipid is greater than 60%;
  • the sucrose fatty acid esters include, but are not limited to, various models of S-1 to S-16;
  • single, double glycerol Fatty acid esters include, but are not limited to, glyceryl monostearate, mono, diolein, mono, dilauric glyceride, mono, bis linoleate, mono, linolenic glyceride, single , dipalmitin, mono, bis-capric glyceride;
  • polyglycerol fatty acid esters including, but not limited to, polyglyceryl stearate, polyglyceryl oleate, polyglyceryl laurate, polyglyceryl myristate Or dimers,
  • the emulsifier is a phospholipid, wherein the content of the phospholipid is 0.2% to 3.5% by weight, preferably the content of the phospholipid is 0.5% to 2.5% by weight.
  • the emulsifier is selected from the group consisting of phospholipids and one or more of the following: sucrose fatty acid esters, mono-, diglycerin fatty acid esters, polyglycerol fatty acid esters, propylene glycol fatty acid esters, lactic acid fatty acid glycerides, spit Temperature 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80; the content of emulsifier is 0.1% to 4% by weight. Preferably, the content of the emulsifier is from 0.2% to 3% by weight.
  • the emulsifier comprises a sucrose fatty acid ester and one or more of the following: phospholipid, mono-, diglycerin fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty acid glyceride, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80; the content of emulsifier is 0.06% to 5% by weight.
  • the content of the emulsifier is preferably from 0.3% to 3% by weight.
  • the emulsifier comprises a mono-, diglycerin fatty acid ester and one or more of the following: phospholipids, sucrose fatty acid esters, polyglycerol fatty acid esters, propylene glycol fatty acid esters, lactic acid fatty acid glycerides, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80; the content of emulsifier is 0.06% to 5% by weight.
  • the content of the emulsifier is preferably from 0.3% to 3% by weight.
  • the emulsifier comprises a polyglycerol fatty acid ester and one or more of the following: phospholipid, sucrose fatty acid ester, mono-, diglycerin fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty acid glyceride, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80; the content of emulsifier is 0.06% to 5% by weight.
  • the content of the emulsifier is preferably from 0.3% to 3% by weight.
  • the emulsifier comprises a propylene glycol fatty acid ester and one or more of the following: phospholipids, sucrose fatty acid esters, polyglycerol fatty acid esters, mono-, diglycerin fatty acid esters, lactic acid fatty acid glycerides, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80; the content of emulsifier is 0.06% to 5% by weight.
  • the content of the emulsifier is preferably from 0.3% to 3% by weight.
  • the emulsifier comprises lactic acid fatty acid glyceride and one or more of the following: phospholipid, sucrose fatty acid ester, polyglycerin fatty acid ester, mono, diglycerin fatty acid ester, propylene glycol fatty acid ester, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80; emulsifier content by weight ratio
  • the content of the emulsifier is preferably from 0.3% to 3% by weight, and is preferably from 0.3% to 3% by weight.
  • the content of the emulsifier of the present invention is 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6% by weight, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2% , 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9 %, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5%, 5.1%, 5.2%, 5.3%, 5.4%, 5.5%, 5.6%, 5.7%, 5.8%, 5.9%, 6%, 6.1%, 6.2%, 6.3%, 6.4%, 6.5%, 6.6%, 6.7%, 6.8%, 6.9%, 5%, 5.1%
  • the phospholipid of the present invention preferably the lecithin (ie phosphatidylcholine) in the phospholipid is greater than 40%, preferably the lecithin in the phospholipid is greater than 50%; preferably the lecithin in the phospholipid The content is more than 60%.
  • lecithin ie phosphatidylcholine
  • the phospholipid is selected from the group consisting of soybean phospholipids, soy lecithin, egg yolk phospholipids, egg yolk lecithin or krill oil.
  • hydrophilic lipid composition of the present invention may further contain other one or more functional ingredients, such as, but not limited to, lutein, lutein ester, coenzyme Q10, carotene, astaxanthin. , lycopene, soy isoflavones, plant extracts or propolis.
  • lutein lutein ester
  • coenzyme Q10 carotene
  • astaxanthin. lycopene
  • soy isoflavones plant extracts or propolis.
  • a special krill oil having a lipidated astaxanthin content of more than 500 mg/kg can be used as a donor fat of astaxanthin in the hydrophilic lipid composition of the present invention.
  • hydrophilic lipid composition of the present invention may further contain taste-improving ingredients such as, but not limited to, flavors or flavors, sweeteners such as stevioside, glycyrrhizin, trichloro Sucrose, and so on.
  • taste-improving ingredients such as, but not limited to, flavors or flavors, sweeteners such as stevioside, glycyrrhizin, trichloro Sucrose, and so on.
  • the hydrophilic lipid composition of the invention has excellent hydrophilicity, and can vibrate in a water-based liquid to rapidly form a uniform and stable emulsion;
  • the hydrophilic lipid composition of the present invention has excellent hydrophilicity, and it can rapidly form a uniform and stable emulsion by shaking in a water-based liquid containing ethanol.
  • the water-based liquid of the present invention comprises water, a liquid having a water content of more than 60%, or an aqueous solution containing ethanol.
  • the vibration of the present invention refers to a movement of a mixture which causes rapid flow, tumbling or/and impact impact in a container by vibration, shaking or shaking, including the user shaking the mixture by hand, or Machine operation is used to oscillate the mixture, for example by robotic operation.
  • the liquid fat of the present invention comprises a fatty acid or fat which exhibits a liquid state at normal temperature and pressure, preferably comprising a saturated or unsaturated fatty acid, a saturated or unsaturated fat, a triglyceride of a saturated or unsaturated fatty acid, a saturated or Diglycerides of unsaturated fatty acids include, for example, but are not limited to, oleic acid, linoleic acid, alpha-linolenic acid, gamma-linolenic acid, medium chain triglycerides, diglycerides, medium long chain fatty acids, and the like.
  • Emulsion is a complex, thermodynamically stable system, especially different oil types or fat-soluble components, due to The lipid-water distribution and binding energy state of each component are different, which is crucial for the stability of the whole system.
  • the multi-component milk system is prone to instability such as fat floating, flocculation or delamination.
  • the production method and process determine the shape and size of the fat globule in the emulsion, and whether microscopic phenomena such as aggregation occur, which affects the instability of the fat floating, flocculation or stratification of the emulsion on the macroscopic level, and also affects The absorption, absorption and utilization of the emulsion by the human body.
  • the environment may be turbid for a long time at a normal temperature or slightly lower than the normal temperature.
  • the phospholipid may precipitate and seriously affect the quality of the product.
  • the inventors have studied that the reason for this phenomenon is that the emulsifier is not easily blended with vegetable oils, for example, the freezing point of phospholipids is higher than the freezing point of vegetable oil, so that phospholipids that cannot be blended with vegetable oil will be at a temperature lower than the freezing point thereof. The precipitate precipitates, causing the oil to become cloudy, or the phospholipids will precipitate.
  • the preparation method of the hydrophilic lipid composition of the present invention is crucial, and the inventors have found that the emulsifier and the vegetable oil are blended and miscible by heating and high-speed mixing, so that the distribution is uniform and further rapid, Precise cooling, or oil-gas-miscible composition, when the emulsifier molecules are rapidly cooled, the emulsifier molecules will form a small molecule microcrystalline colloidal solution in a highly dispersed state, achieving a stable emulsifier and vegetable oil. Mixed.
  • the present invention provides a preparation method of the above hydrophilic lipid composition, which comprises:
  • the oily liquid is vacuum degassed, filled, sealed, packaged and inspected to obtain the hydrophilic lipid composition of the present invention.
  • the hydrophilic lipid composition prepared by the above method of the present invention is usually a pale yellow to dark yellow transparent oil. Further, the hydrophilic lipid composition and the water-based liquid are blended into an emulsion by shaking.
  • the affinity and dispersibility with the water-based liquid are critical, and the inventive method for preparing an oil-gas miscible composition for an emulsifier Blending is produced in the liquid fat and has a good effect on the hydrophilicity of the lipid composition.
  • the present invention provides a second preparation method of a hydrophilic lipid composition, which comprises:
  • the hydrophilic lipid composition prepared by the above method of the present invention is a foam-type oily substance containing nitrogen gas, which exhibits a non-transparent shape, and it is visually observed that fine or uniform bubbles are contained therein, or the liquid fat or oil exhibits a foamy shape. Further, the hydrophilic lipid composition and the water-based liquid are blended into an emulsion by shaking.
  • the present invention provides a method for preparing a third of the hydrophilic lipid composition, which comprises:
  • emulsifier a mixture of the emulsifier and the emulsifier 3 to 7 times the weight of the fat-soluble substance prepared in (2), placed in an emulsification tank, continuously passed into the oily liquid or kept emulsified
  • the pressure in the tank is stronger than 1.3 atm, and is stirred at a stirring speed of more than 300 r/min, so that the oily liquid exhibits a non-transparent nitrogen-rich foam-like oily liquid, or the oil is foamy, and the stirring is stopped;
  • the present invention provides a hydrophilic lipid composition comprising an emulsifier and a liquid fat, which is characterized by being produced by the above first preparation method, the second preparation method or the third preparation method.
  • the present invention provides a foam type hydrophilic lipid composition
  • the emulsifier being selected from the group consisting of the following Or a variety of substances: phospholipids, sucrose fatty acid esters, mono-, diglycerin fatty acid esters, polyglycerol fatty acid esters, propylene glycol fatty acid esters, lactic acid fatty acid glycerides, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80, wherein the content of the emulsifier is 0.05% to 8% by weight;
  • the fat-soluble substance A is selected from the following one Or a plurality of substances: oleic acid, linoleic acid, linolenic acid, medium chain triglyceride, diglyceride, medium and long chain fatty acid, wherein
  • the hydrophilic lipid composition provided by the present invention can rapidly form an emulsion by shaking in a water-based liquid, for example, by the operation of shaking, the hydrophilicity of the present invention.
  • the lipid composition is mixed with the water-based liquid in a closed container, for example, in a beverage bottle closed with a cap, the total volume of the hydrophilic lipid composition and the water-based liquid in the container is not higher than the total capacity of the container.
  • the lipid composition of the present invention and the water-based liquid can form an emulsion immediately, and the emulsion is allowed to stand for 5 minutes or even 10 minutes.
  • the uniform and stable emulsion is maintained, which greatly facilitates the preparation and consumption of the consumer or the patient; in addition, the hydrophilic lipid composition is formulated with the water-based liquid to form an emulsion, even after a long period of time. After standing and stratifying, it can be dispersed into an emulsion after slight shaking, and does not affect drinking or eating.
  • the inventors have described the process or technique of instantaneously forming an emulsion by a lipid composition provided by the present invention and a water-based liquid under the action of shaking, which is called "oil-water instantaneous mixing".
  • the present invention provides a method for using a hydrophilic lipid composition containing an emulsifier and a liquid fat, which comprises adding a hydrophilic lipid composition to a water-based liquid and shaking it to form an opacity.
  • a liquid for example, a method of using a product for nutritional treatment such as drinking oil or drinkable health oil;
  • the present invention provides a method of using the hydrophilic lipid composition comprising mixing the hydrophilic lipid composition of the present invention with a water-based liquid in a closed container. Shake it to make it an emulsion;
  • the water-based liquid comprises water, a liquid having a water content of more than 60%, or an aqueous solution containing ethanol; the shaking, preferably at least one shaking time in one second, and the shaking time is not Less than 1 second.
  • the present invention provides a method for mixing and mixing a hydrophilic lipid composition containing an emulsifier and a liquid fat with a water-based liquid, comprising shaking a mixture of a lipid composition and a water-based liquid to form an opacifier.
  • the liquid, the water-based liquid includes water, a liquid having a water content of more than 60%, or an aqueous solution containing ethanol.
  • the hydrophilic lipid composition containing an emulsifier and a liquid fat provided by the present invention has rapid water emulsification performance, and the hydrophilic lipid composition of the present invention is preferably formulated into an opacity using a blending bottle.
  • Liquid in particular, as a method for rapidly formulating a hydrophilic lipid composition with a water-based liquid into an aqueous emulsion by pouring a hydrophilic lipid composition and a water-based liquid into a mixing bottle, wherein
  • the weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 3:1, preferably the weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 10:1, such that the hydrophilic lipid composition and water
  • the total volume of the base liquid does not exceed 98% of the capacity of the blending bottle. Tighten the lid of the blending bottle and shake the blending bottle at least once in 1 second by hand or robot to shake the blending bottle for no more than 10 seconds.
  • the mixing bottle is shaken for no more than 5 seconds.
  • the distance of the mixing bottle is not less than 10 cm per movement, and the mixture is moved to the remaining space of the mixing bottle, preferably the mixing solution is adjusted to the bottle.
  • the remaining space moves and impacts the cover of the bottle , a uniform emulsion can be formed, which is allowed to stand at room temperature for 5 minutes to maintain a uniform emulsion state without delamination;
  • the dispensing bottle includes a glass bottle with a lid, a plastic bottle with a lid, Aluminum-plastic carton with lid, metal container with lid, for example, polymer PET bottle, high-density polyethylene bottle, etc.; preferably, the volume of the bottle is not more than 3 liters, and most preferably the volume of the bottle is not more than 3 liters, preferably volume of 2.5 liter, 1.5 liter, 1 liter, 0.9 liter, 0.8 liter, 0.7 liter, 0.6 liter, 0.5 liter, 0.45 liter, 0.4 liter,
  • the hydrophilic lipid composition containing the emulsifier and the liquid fat of the invention has unexpected rapid water emulsification performance, and brings great convenience and novelty to its use.
  • the hydrophilic lipid composition of the present invention can be rapidly and instantaneously dispersed in water by shaking, and has a property of being fast and hydrophilic. Further, the present invention provides a technical solution for rapidly formulating the hydrophilic lipid composition into an emulsion.
  • a hydrophilic lipid composition comprising an emulsifier, a fat-soluble substance A and a fat-soluble substance B, the emulsifier being selected from one or more of the following: a phospholipid, a sucrose fatty acid ester, a single, a double glycerin Fatty acid esters, polyglycerol fatty acid esters, propylene glycol fatty acid esters, lactic acid fatty acid glycerides, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80, wherein the content of the emulsifier is 0.05% to 8% by weight, preferably the content of the emulsifier is 0.1% to 6% by weight; the fat-soluble substance A is selected from the following one Or a plurality of substances: oleic acid, linoleic acid, ⁇ -linolenic acid, ⁇ -linolenic acid, medium chain trig
  • the fat-soluble substance B is selected from one or more of the following: nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleum Acid glycerides, phosphatidylserine, phytosterols, phytosterol esters, plant stanol esters, rice bran fatty alkanols, The phosphatidylcholine, wherein the content of the fat-soluble substance B is 0 to 30% by weight, characterized in that the hydrophilic lipid composition and the water-based liquid are oscillated by shaking, and can be formed within 5 seconds.
  • Emulsion and the formed emulsion is allowed to stand for at least 1 min to maintain uniformity In the emulsion state, no delamination occurs, wherein the weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 3:1, preferably the weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 10: 1;
  • the water-based liquid comprises: water, a liquid having a water content of more than 60%, or an aqueous solution containing ethanol;
  • the vibration refers to a movement, a tumbling or/and a collision impact of the mixture in the container by vibration, shaking or shaking, including shaking the mixture by the user by hand, or using a machine operation.
  • the mixture is shaken, for example by the operation of a robot.
  • the speed of the shaking is preferably a frequency at which at least one shaking occurs in one second;
  • the medium long chain fatty acid comprises a medium chain fatty acid or a long chain fatty acid
  • the content of the fat-soluble substance B is 0.01% to 30% by weight;
  • hydrophilic lipid composition and the water-based liquid are shaken to form an emulsion within 4 seconds;
  • hydrophilic lipid composition and the water-based liquid are shaken to form an emulsion within 3 seconds;
  • hydrophilic lipid composition and the water-based liquid are shaken to form an emulsion within 2 seconds;
  • hydrophilic lipid composition and the water-based liquid are shaken to form an emulsion within one second.
  • the hydrophilic lipid composition of the present invention belongs to a fat type composition, and the hydrophilic lipid composition of the present invention forms an emulsion in a water-based liquid for convenient use and better absorption. very necessary.
  • the present invention provides the hydrophilic lipid composition as a health food or beverage companion for various water-based liquid foods, preferably as a homogenate diet, milk, beverage, aqueous solution, juice, coffee, liquid food, Such as porridge, rice paste, batter, brewed food, such as brewed cereal, brewed milk powder, brewed coffee, brewed solid beverage, etc.; preferably used as a blending oil for drinking water, drinkable healthy oil; It is preferred to use a water-based liquid formulated into an emulsion.
  • the present invention further provides a packaging composition comprising the hydrophilic lipid composition of the present invention and a water-based liquid, the method of which the packaging composition is formulated into an emulsion.
  • a packaging composition comprising separately packaging and combining a hydrophilic lipid composition and a water-based liquid, the hydrophilic lipid composition comprising a liquid fat and an emulsifier, wherein the liquid fat is selected from the group consisting of One or more substances: medium chain triglyceride, ⁇ -linolenic acid, ⁇ -linolenic acid, diglyceride, oleic acid, linoleic acid, medium and long-chain fatty acid, liquid fat in hydrophilic lipid composition The content is greater than 45% by weight;
  • the emulsifier is selected from one or more of the following: phospholipids, sucrose fatty acid esters, mono-, diglycerin fatty acid esters, polyglycans Oil fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty acid glyceride, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80
  • the content of the emulsifier in the hydrophilic lipid composition is 0.05% to 8% by weight;
  • the water-based liquid is selected from the group consisting of water, a liquid having a water content of more than 60%, or an aqueous solution containing ethanol;
  • the weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 3:1;
  • the sum of the volume of the water-based liquid and the hydrophilic lipid composition is not more than 98% of the capacity of the container containing the water-based liquid.
  • the hydrophilic lipid composition further contains a fat-soluble substance B selected from one or more of the following substances: nervonic acid, DHA, EPA, and arafflene.
  • Acid vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phospholipid
  • the choline is a content of the fat-soluble substance B in the hydrophilic lipid composition in an amount of from 0.01% to 30% by weight.
  • hydrophilic lipid composition of various combinations, specific components, ratios, preparation methods, and formulation methods provided by the present invention are all applicable to the hydrophilic lipid composition of the above-mentioned packaging composition.
  • the packaging composition comprises separately packaging and combining the hydrophilic lipid composition of the present invention and a water-based liquid, for example, forming a combination in the same package or packaging, or, for example, a fat
  • Individual packaging of the composition of the composition and individual packaging of the water-based liquid are combined together in the form of a affixing, labeling or packaging kit to form a packaging composition, which is "combined by means of adhesive fastening, label fixing or packaging kit" ", means that the individual packaging of the lipid composition is combined with the independent packaging of the water-based liquid by means of tape or adhesive glue; or the product label of the lipid composition, the product label of the water-based liquid, through the label Bundling, wrapping, winding, etc., combining the individual packaging of the lipid composition with the independent packaging of the water-based liquid; or the independent packaging of the lipid composition and the independent packaging of the water-based liquid into a packaging package , put together, for example, a groove is formed in the container of the water-based liquid, and the package
  • the lid member of the container When in use, the lid member of the container is opened, the lipid composition in the lid member is released, mixed with the water-based liquid in the container, and further, uniformity is formed by shaking.
  • the emulsion for example, the cover member of the container can be referred to a technical solution similar to that disclosed in International Publication WO2007/129126.
  • the packaging composition comprises separately packaging the hydrophilic lipid composition of the present invention and presenting it in the same package unit simultaneously with the dispensing bottle, the dispensing bottle being empty with a lid
  • the bottle preferably the adjustment bottle, is marked with a scale line for the amount of water-based liquid to be added.
  • the water-based liquid is further added to facilitate the preparation and shaking, so that the fatty acid composition can be well formed into a uniform emulsion in the water-based liquid, and the user can also decide to add the hydrophilic lipid.
  • the packaging composition may be free of the blending bottle, but the label of the packaging of the hydrophilic lipid composition is marked with the combination of the lipids.
  • the content of the emulsion is obtained by mixing the mixture with the water-based liquid and shaking the mixture, and is also the technical content of the packaging composition of the lipid composition of the present invention, that is, the hydrophilic lipid composition.
  • the product label is marked with the content of the hydrophilic lipid composition mixed with the water-based liquid and obtained by shaking to obtain an emulsion.
  • the above packaging composition is more convenient for the combination and storage of the lipid composition and the water-based liquid, and is more advantageous for the preparation of the lipid composition and the water-based liquid, and the hydrophilic lipid composition is mixed with the water-based liquid.
  • the method for forming an emulsion comprises: pouring a hydrophilic lipid composition into a container containing a water-based liquid, wherein a weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 3:1, so that the pro The total volume of the aqueous lipid composition and the water-based liquid does not exceed 98% of the container capacity. Tighten the lid of the container and shake the container at least once in 1 second by hand or robot to shake the container.
  • the container when the container is shaken, the container is displaced by a distance of not less than 10 cm each time, and the mixed liquid is moved to the remaining space of the container to form an emulsion, preferably, when the container is shaken, the mixed solution is directed to the container.
  • the remaining space moves and impacts the cover of the bottle;
  • hydrophilic lipid composition comprises any of the hydrophilic lipid compositions of the present invention.
  • the water-based liquid is selected from the group consisting of water, a liquid having a water content of more than 60%, or an aqueous solution containing ethanol;
  • the water-based liquid container is selected from the group consisting of a glass bottle with a lid, a plastic bottle with a lid, an aluminum-plastic paper box with a lid, a metal container with a lid, and a container having a volume of no more than 3 liters.
  • the water-based liquids of the present invention include, but are not limited to, water, aqueous solutions of carbohydrates (eg, monosaccharides, disaccharides, oligosaccharides, polysaccharides, etc.), aqueous solutions of dietary fibers (eg, inulin, oligofructose, Polydextrose), aqueous suspension of dietary fiber, aqueous solution of amino acid, aqueous solution of vitamins, aqueous solution of electrolyte (such as aqueous solution of potassium chloride or magnesium sulfate), aqueous solution or suspension of probiotics, animal emulsion (such as milk, Milk emulsion of goat milk, horse milk), animal protein powder (such as milk powder, water emulsion of goat milk powder, water emulsion of refined milk protein powder), water emulsion of vegetable protein powder (soy protein An aqueous emulsion of powder, peanut protein powder), liquid fruit juice, liquid vegetable juice, water extract, etc
  • the water-based liquid of the present invention is selected from the group consisting of an aqueous solution of one or more of the following: sucrose, glucose, fructose, maltose, chitooligosaccharide, oligofructose, xylooligosaccharide, polydextrose, inulin, Taurine, cysteine, cystine, glycine, aspartic acid, asparagine, glutamic acid, glutamine, lysine, arginine, ornithine, vitamin C, vitamin B, L-carnitine, folic acid, nicotinic acid, choline, inositol; or, preferably, the water-based liquid of the present invention is selected from the group consisting of an animal emulsion, an aqueous emulsion of animal protein powder or an aqueous emulsion of vegetable protein powder.
  • the above water-based liquid on the one hand, not only provides water-soluble or protein-based nutrients, but also provides the pros provided by the present invention.
  • the aqueous lipid composition has a nutritional synergistic pharmacological effect.
  • the above water-based liquid is more advantageous for rapidly forming an emulsion with a hydrophilic lipid composition under the action of vibration, and maintaining good and not easy to stratify. The stability of the emulsion.
  • the present invention also provides the hydrophilic lipid composition for use in medicine, special medical use formula, health food, nutraceutical or cosmetic, etc.
  • the hydrophilic lipid composition contains
  • the unsaturated fatty acid and fat health component for rejuvenating human health and disease are especially suitable for preparing medicine, special medical use formula, health food, nutritious food or cosmetics, and on the other hand, the hydrophilic lipid combination of the present invention
  • the substance is in the form of a liquid, and can be used as a solvent for oils and fats, and is soluble in a fat-soluble drug, and can be further formulated and dispersed in a water-based liquid to form an emulsion, thereby facilitating oral administration, absorption and utilization of a fat-soluble drug.
  • fat-soluble drugs include adefovir dipivoxil, tenofovir, lutein, coenzyme Q10, and the like.
  • it when used in cosmetics, it is used as an emollient oil, skin care essential oil, hair care essential oil, or dissolved in water as a hydrating and oil replenishing agent for the face and skin, as well as skin nutrient oil, etc., for skin care.
  • the hydrophilic lipid composition of the present invention can be used as a drinking and blending oil, and can be used for health, health care, and nutritional treatment of health oil.
  • the present invention also provides a hydrophilic lipid composition containing the emulsifier and liquid fat by mixing with a water-based liquid and further oscillating to prepare an emulsion, in the preparation or formulation of a drug, special medicine Uses in formulas, health foods, nutraceuticals or cosmetics, especially in the preparation or deployment of immediate oral intake medications, special medical use formulas, health foods, nutraceuticals, or in the preparation or deployment of ready-to-use
  • the application in cosmetics is very convenient for the user to immediately deploy and use.
  • the present invention also provides an application of a hydrophilic lipid composition containing an emulsifier and a liquid fat by mixing with a water-based liquid to prepare an emulsion by shaking.
  • the invention also provides a homogenate diet for preparing a special medical use formula food by mixing a hydrophilic lipid composition containing an emulsifier and a liquid fat with a water-based liquid and further oscillating to form an emulsion.
  • a hydrophilic lipid composition containing an emulsifier and a liquid fat with a water-based liquid and further oscillating to form an emulsion.
  • the present invention also provides a hydrophilic lipid composition containing an emulsifier and a liquid fat, which is prepared by mixing with a water-based liquid and being shaken to prepare an emulsion, and is further used for the production of meals, using opacity.
  • Liquid instead of water in the production of meals is used in the production of meals, including but not limited to the application of steamed food, cooked food, prepared flour, mixed foods or prepared foods and beverages.
  • the hydrophilic lipid composition of the present invention can provide unsaturated fatty acids beneficial to the treatment of human health and diseases, such as nervonic acid, ⁇ -linolenic acid, ⁇ -linolenic acid, DHA, EPA, and peanuts.
  • the agent and the fat-soluble substance have good pharmacological synergistic effects, and have good synergistic effects on human health, especially in oral supplementation of phospholipids, unsaturated fatty acids and fat-soluble drugs.
  • the present invention also provides a hydrophilic lipid composition containing an emulsifier and a liquid fat through with water
  • the base liquid is mixed, shaken to prepare an emulsion for oral drinking, and is used for preparing medicines or special foods for preventing and treating cardiovascular and cerebrovascular diseases; and for preparing medicines or special foods for nourishing or protecting cranial nerves
  • drugs for preventing and treating neurodegenerative diseases in the preparation of drugs for reducing the risk of myocardial infarction, stroke or cardiovascular disease; in the preparation of improving myocardial ischemia and improving cerebral ischemia, protecting the heart and brain
  • application in the preparation of drugs or special foods for treating fatty liver application in preparation of drugs or special foods for weight loss; Use of fatigued drugs or special foods; application in the preparation of drugs or special foods that provide unsaturated fatty acids; or in the preparation of drugs or special foods that provide fat-soluble drugs
  • the hydrophilic lipid composition of the present invention can also be used in the preparation of meals, and the hydrophilic lipid combination of the present invention can be used in any meal which needs to be prepared or formulated with water.
  • the emulsion formulated with water and water replaces the application of water in the preparation of meals.
  • the prepared food not only supplements the essential fatty acids and liquid fat, but also the prepared meals.
  • Concentrated oily aromas help to increase appetite and, more importantly, the process of making meals, for the consumer, on the one hand, is a pleasure, especially by passing oil-based substances and water-based substances for a second or two.
  • the vibration process of the clock instantly turns into an emulsion, which greatly enhances the consumer's desire to drink or eat.
  • the self-producing diet process produces a psychological desire to contribute to the healthy and nutrient-based oil-based substance of the present invention.
  • Ingestion on the other hand, the process of formulating the hydrophilic lipid composition of the present invention with water is a process of cooking, brain-moving and using the eye, especially for oil-based substances and water-based substances.
  • the substance oscillates through a second or two Cheng, instantly becomes an emulsion, greatly increasing the consumer's desire to drink or eat.
  • the self-producing diet process produces a psychological desire to contribute to the healthy nutrition of the present invention; In addition, this process of vibration (vibration and shaking) releases stress. This process brings a pleasant mood and optimizes eating mood. This pleasant state helps the diet to be healthy, not only helpful.
  • the action of the oil-based substance of the healthy nutrition of the invention can further improve the consumption of the beverage or the homogenized meal, reduce the rate of discarded beverages, and reduce waste and pollution.
  • the hydrophilic lipid composition provided by the invention realizes the product blending mode of oil-water rapid blending, and has great significance.
  • the oil-based substance and the water-based substance are separately packaged separately, and the individual packages of the two are separately combined, and the two are rapidly mixed to form an emulsion by shaking and mixing.
  • This method allows oil-based substances to be independently stored with water-based substances, so that their respective stability is significantly improved, no need to add an emulsion stabilizer, avoiding degradation of unsaturated fatty acids, greatly improving product stability and ensuring Quality, maintain a good flavor and taste, and also extend the shelf life or shelf life, which is conducive to the quality assurance and circulation of goods.
  • hydrophilic lipid composition provided by the present invention can not only bring more healthy fat to consumers, such as medium chain triglycerides, omega-3 fatty acids, omega-6 fatty acids, phospholipids, Arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid, plant sterols and other health, nutrition, disease prevention and control substances, such as protecting the cardiovascular and cerebrovascular, improving intelligence, nutrition nerves; and making consumers more It is easy and convenient to obtain these substances which are very beneficial to health and disease prevention by means of beverages, homogenized meals and ordinary meals.
  • hydrophilic lipid composition provided by the invention is beneficial to improving people's existing eating habits, and even beneficial to improving human meal making habits and meal matching concepts.
  • Bioavailability refers to the degree of utilization and utilization rate of the preparation absorbed into the blood circulation.
  • the present invention contains an emulsifier, a fat-soluble substance, rapidly forms an emulsion in a water-based liquid, has excellent water-oil solubility, and is active as a fat-soluble substance.
  • Oral preparations have a significant promoting effect and significance in the extent and speed of absorption into the blood circulation, which is of great significance for the improvement of the bioavailability of fat-soluble substances.
  • the absorption process of the preparation into the gastrointestinal tract is divided into two stages, namely, dispersion and absorption of the gastrointestinal wall. First, it needs to be dispersed in the gastric juice or intestinal fluid, and then contacted and attached to the gastrointestinal wall for absorption and into the blood.
  • the fat-soluble substances are prepared in the form of a water-dispersible emulsion, and the dissolution and dispersion speed of the fat-soluble substances are remarkable. Accelerate, greatly increase the degree of dispersion and dispersion speed in gastric juice or intestinal juice, make the fat-soluble substance more fully contact with the gastrointestinal wall, and adhere to the gastrointestinal wall to absorb the active ingredients into the blood, which is more sufficient. The improvement of the bioavailability of soluble substances is of great significance.
  • a hydrophilic lipid composition provided by the present invention such as nervonic acid, DHA, EPA, phosphatidylserine, medium chain triglyceride, ⁇ -linolenic acid, ⁇ -linolenic acid, etc.
  • nervonic acid such as nervonic acid, DHA, EPA, phosphatidylserine, medium chain triglyceride, ⁇ -linolenic acid, ⁇ -linolenic acid, etc.
  • the hydrophilic lipid composition of the invention and the preparation method thereof solve many shortcomings of the prior art, and have the following advantages: 1. Oil-based components, no water, good stability; 2. Excellent hydrophilicity, energy It is mixed with water and dispersed to form an emulsion, which is convenient for consumption and easy to operate. 3. It is convenient and quick to mix.
  • a uniform emulsion can be formed in 1 to 5 seconds to prepare or make a diet. Bring a pleasant mood, help release stress and diet, optimize eating mood; 4, improve the bioavailability of functional fatty acids or fat-soluble substances; 5, the emulsion formed has better stability, static After being placed for more than 5 minutes, a uniform and stable emulsion can be maintained. 6. After the stratification is formed for a long time, the emulsion can be formed by a slight shaking, which is beneficial to the user intermittently. Drink or take it orally.
  • Example 1 A hydrophilic lipid composition, a preparation and formulation method thereof, and a combination use.
  • a hydrophilic lipid composition in a percentage by weight, containing:
  • the phospholipid is selected from the group consisting of soybean phospholipids, soy lecithin, egg yolk phospholipids, egg yolk lecithin or krill oil.
  • the preparation method thereof comprises:
  • the liquid prepared in (1) is placed in an emulsification tank, heated to a temperature of 45 ° C or higher, and stirred at a stirring speed of more than 500 r/min for 3 to 25 minutes, and then at 3 to 5 minutes.
  • the liquid is quickly cooled to below 25 ° C, the stirring is stopped, and the mixture is allowed to stand; or, the liquid prepared in (1) is placed in an emulsification tank, and the temperature of the liquid is 45 ° C or higher, and the pressure is performed in the homogenizer. Homogenization of 20 to 58 MPa, and then quickly cool the liquid to below 25 ° C within 3 to 5 minutes, and stop stirring;
  • the preparation method 2 thereof includes:
  • the oily liquid prepared in (2) is filled in a container, and the container is further filled with nitrogen gas, and the gas pressure in the container is stronger than 1.2 atm, sealed and sealed, packaged, and inspected.
  • the preparation method thereof includes:
  • emulsifier a mixture of the fat-soluble substance prepared in (2) in an amount of 3 to 7 times by weight of the emulsifier and the emulsifier, placed in an emulsification tank, continuously supplied with nitrogen into the oily liquid or kept emulsified
  • the pressure in the tank is stronger than 1.3 atmospheres, and is stirred under the stirring speed of more than 300r/min, so that the oily liquid exhibits a non-transparent nitrogen-rich foam-type grease, or the oil is foamed, and the stirring is stopped;
  • the oily liquid prepared in (4) is filled in a container, and the container is further filled with nitrogen gas and the gas pressure in the container is stronger than 1.2 atm, sealed and sealed, packaged, and inspected.
  • Rapid compounding performance Pour any proportion of the hydrophilic lipid composition and water-based liquid in the present embodiment into a mixing bottle, wherein the weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 10 :1, so that the total volume of the hydrophilic lipid composition and the water-based liquid does not exceed 98% of the capacity of the blending bottle, tighten the lid of the blending bottle, and shake the blending bottle at least once in 1 second by hand or robot.
  • the frequency of the bottle is shaken for up to 5 seconds. When the bottle is shaken, the distance of the bottle is not less than 10 cm per movement, and the mixture is moved to the remaining space of the bottle, preferably the mixture is dispensed.
  • the remaining space moves and impacts the cover of the bottle, and according to the above method, a uniform emulsion can be formed.
  • the emulsion is still in a uniform emulsion after standing at room temperature for 5 minutes, and no delamination occurs; , is a glass bottle with a lid, a plastic bottle with a lid, an aluminum-plastic paper box with a lid, a metal container with a lid, for example, a polymer PET bottle, a high-density polyethylene bottle, etc.; Capable of tightening the lid for vibrating and dispensing, preferably mixing the bottle
  • the volume of the bottle is not more than 3 liters.
  • the volume of the bottle is preferably 0.5 liter.
  • the aqueous base liquid includes water, a liquid having a water content of more than 60%, or an aqueous solution containing ethanol.
  • the water-based liquid is selected from the following one.
  • Aqueous solution of one or more substances sucrose, glucose, fructose, maltose, chitosan oligosaccharide, oligofructose, xylooligosaccharide, polydextrose, inulin, taurine, cysteine, cystine, glycine, Aspartic acid, asparagine, glutamic acid, glutamine, lysine, arginine, ornithine, vitamin C, vitamin B, L-carnitine, folic acid, niacin, choline, inositol.
  • Example 2 Hydrophilic lipid composition, preparation and formulation method thereof.
  • a hydrophilic lipid composition in a percentage by weight, containing:
  • the phospholipid is selected from the group consisting of soybean phospholipid, soybean lecithin, egg yolk phospholipid, egg yolk lecithin or krill oil;
  • the donor vegetable oil of ⁇ -linolenic acid is selected from the group consisting of linseed oil, perilla seed oil, pumpkin seed oil, and peony seed.
  • ⁇ -linolenic acid donor oil is selected from ⁇ -linolenic acid oil
  • linoleic acid donor vegetable oil is selected from soybean oil, corn oil, peanut oil, sunflower oil, olive oil , milk thistle seed oil, pumpkin seed oil, long handle almond oil, palm oil, sesame oil, walnut oil, rapeseed oil, safflower seed oil, grape seed oil, salicin seed oil, wheat germ oil, corn Germ oil, light-skinned avocado oil, salted wood fruit oil, peony seed oil, samara oil, glutinous rice oil, tomato seed oil, pepper seed oil, mustard seed oil, tea oil (including tea seed oil, Camellia seed oil or tea tree oil), rice bran oil, shea butter, borage oil, pepper seed oil, coconut oil or cottonseed oil; oleic acid donor vegetable oil is selected from the group consisting of soybean oil, corn oil, peanut oil, sunflower oil, Olive oil, pumpkin seed oil,
  • the preparation method is the same as the preparation method 1, the preparation method 2 or the preparation method 3 in the first embodiment, and the preparation method in the embodiment 1 can be completely applied to the embodiment.
  • any one of the proportions of the hydrophilic lipid composition is formulated into an emulsion by shaking with a water-based liquid, preferably the aqueous liquid is selected from the aqueous solution of one or more of the following: sucrose, Glucose, fructose, maltose, chitosan oligosaccharide, oligofructose, xylooligosaccharide, polydextrose, inulin, taurine, cysteine, cystine, glycine, aspartic acid, asparagine, valley Acid, glutamine, lysine, arginine, ornithine, vitamin C, vitamin B, L-carnitine, folic acid, niacin, choline, inositol, or water-based liquid selected from animal lotions, animals An aqueous emulsion of protein powder or an aqueous emulsion of vegetable protein powder.
  • Example 3 a hydrophilic lipid composition, a preparation thereof, and a formulation method.
  • a hydrophilic lipid composition in a percentage by weight, containing:
  • the phospholipid comprises soybean phospholipid, soybean lecithin, egg yolk phospholipid, egg yolk lecithin or krill oil
  • the donor vegetable oil of linoleic acid is selected from the group consisting of soybean oil, corn oil, peanut oil, sunflower oil, olive oil, water fly Quail seed oil, pumpkin seed oil, long handle almond oil, palm oil, sesame oil, walnut kernel oil, rapeseed oil, safflower seed oil, grape seed oil, salicin seed oil, wheat germ oil, corn germ oil, Light-skinned avocado oil, salted wood fruit oil, peony seed oil, samara oil, glutinous rice oil, tomato seed oil, pepper seed oil, mustard seed oil, tea oil (including tea seed oil, camellia seed oil) Or tea tree oil), rice bran oil, chili seed oil, pomegranate seed oil, Brucea javanica oil or coconut oil
  • oleic acid donor vegetable oil is selected from the group consisting of soybean oil, corn oil, peanut oil, sunflower oil, olive
  • the preparation method is the same as the preparation method 1, the preparation method 2 or the preparation method 3 in the first embodiment, and the preparation method in the embodiment 1 can be completely applied to the embodiment.
  • any one of the proportions of the hydrophilic lipid composition is formulated into an emulsion by shaking with a water-based liquid.
  • the water-based liquid is selected from an aqueous solution of one or more of the following: sucrose, glucose , fructose, maltose, chitosan oligosaccharide, oligofructose, xylooligosaccharide, polydextrose, inulin, taurine, cysteine, cystine, glycine, aspartic acid, asparagine, glutamine Acid, glutamine, lysine, arginine, ornithine, vitamin C, vitamin B, L-carnitine, folic acid, niacin, choline, inositol, or water-based liquid selected from animal lotion, animal protein An aqueous emulsion of powdered water or vegetable protein powder.
  • Example 4 a hydrophilic lipid composition, a preparation thereof, and a formulation method.
  • a hydrophilic lipid composition in a percentage by weight, containing:
  • the phospholipid is selected from the group consisting of soybean phospholipid, soybean lecithin, egg yolk phospholipid, egg yolk lecithin or krill oil;
  • the donor vegetable oil of ⁇ -linolenic acid comprises linseed oil, perilla seed oil, pumpkin seed oil, peony seed oil , Eucommia seed oil or Meito fruit oil;
  • ⁇ -linolenic acid donor oil is selected from ⁇ -linolenic acid oil;
  • linoleic acid donor vegetable oil is selected from soybean oil, corn oil, peanut oil, sunflower oil, olive oil, Milk thistle seed oil, pumpkin seed oil, long handle almond oil, palm oil, sesame oil, walnut oil, rapeseed oil, safflower seed oil, grape seed oil, salicin seed oil, wheat germ oil, corn germ Oil, light-skinned avocado oil, salted wood fruit oil, peony seed oil, samara oil, glutinous rice oil, tomato seed oil, pepper seed oil,
  • the preparation method is the same as the preparation method 1, the preparation method 2 or the preparation method 3 in the first embodiment, and the preparation method in the embodiment 1 can be completely applied to the embodiment.
  • any one of the proportions of the hydrophilic lipid composition is formulated into an emulsion by shaking with a water-based liquid.
  • the water-based liquid is selected from an aqueous solution of one or more of the following: sucrose, glucose , fructose, maltose, chitosan oligosaccharide, oligofructose, xylooligosaccharide, polydextrose, inulin, taurine, cysteine, cystine, glycine, aspartic acid, asparagine, glutamine Acid, glutamine, lysine, arginine, ornithine, vitamin C, vitamin B, L-carnitine, folic acid, niacin, choline, inositol, or water-based liquid selected from animal lotion, animal protein An aqueous emulsion of powdered water or vegetable protein powder.
  • the hydrophilic lipid composition of any one of Examples 2 to 4 was obtained, and had a good rapid formulation property. Rapid formulation performance: Pour any proportion of the hydrophilic lipid composition of the embodiment with a water-based liquid into the mixing bottle, wherein the weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 3: 1. Preferably, the weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 10:1, so that the total volume of the hydrophilic lipid composition and the water-based liquid does not exceed 50% of the capacity of the blending bottle, and the mixing bottle is tightened. Cover, use the hand or robot to shake the bottle at least once in 1 second, so that the bottle shakes for up to 5 seconds.
  • the distance of the bottle is not less than 10 cm.
  • moving the mixture to the remaining space of the blending bottle preferably moving the mixture to the remaining space of the blending bottle and impacting the cap of the blending bottle, as described above, to form a uniform emulsion, the emulsion at room temperature After standing for 5 minutes, it still shows a uniform emulsion without delamination;
  • the matching bottle is a glass bottle with a lid, a plastic bottle with a lid, an aluminum-plastic paper box with a lid, a metal container with a lid, for example , polymer PET bottles, high density polyethylene bottles, etc.; with cover is
  • the volume of the blending bottle is not more than 3 liters, for example, preferably the volume of the blending bottle is 0.5 liter
  • the aqueous-based liquid comprises water, a liquid having a water content of more than 60%, or contains ethanol.
  • Aqueous solutions for example, but not limited to, animal emulsions, fruit juices, fruit and vegetable beverages, plant extracts or beverages, carbohydrate solutions or beverages, vegetable protein beverages, aqueous emulsions of animal milk powder, aqueous solutions of amino acids, and the like.
  • Packing combination a packaging composition comprising independently packaging a hydrophilic lipid composition of any one of the embodiments and presenting in the same package or the same package simultaneously with the dispensing bottle,
  • the dispensing bottle is an empty bottle with a lid; or the conditioning bottle is pre-loaded with a volume of water-based liquid for directly adding the fatty acid composition to the mixing bottle to form a uniform emulsion by shaking; or
  • the independent packaging and the blending bottle of the hydrophilic lipid composition are simultaneously present in one package or the packaging bag, or may be formed by sticking and fixing, and the label is fixed, or may be
  • the packaging bottle or the packaging bag containing the hydrophilic lipid composition is fixed together with the dispensing bottle in the form of a packaging kit, or the packaging composition contains the hydrophilic lipid of any one of the ratios in the embodiment.
  • the composition, and the labeling body thereof has a content obtained by shaking a hydrophilic lipid composition and a water-based liquid to obtain an emulsion.
  • the sum of the volume of the water-based liquid and the hydrophilic lipid composition is not more than 98% of the capacity of the container containing the water-based liquid or the capacity of the blended bottle.
  • the hydrophilic lipid composition of any one of the examples is separately sealed in the chamber of the lid member of the container, the water-based liquid is sealed in the container, and the lid member of the container is mounted on the container The container is sealed at the opening so that the lipid composition and the water-based liquid are each independently sealed.
  • the lid member of the container is opened to release the lipid composition in the lid member, and the water-based liquid in the container Mixing, further, forming a uniform emulsion by shaking;
  • the lipid composition in the chamber of the lid member of the container is injected into the water-based liquid in the form of a liquid column having a diameter of 0.4 mm to 2 mm, for example, by a high-pressure gas in a chamber of the lid member of the container.
  • the composition is sprayed out, or the lipid composition is sprayed by means of piston pressurization or bolus injection, and the lipid composition is mixed with a water-based liquid and shaken to form an emulsion, the water-based liquid including water, A liquid having a water content of more than 60% or an aqueous solution containing ethanol.
  • the sum of the volume of the water-based liquid and the hydrophilic lipid composition is not more than 98% of the capacity of the container containing the water-based liquid.
  • Example 6 the hydrophilic lipid composition of any one of Examples 1 to 4, 1 g of the hydrophilic lipid composition was added, and 2 to 150 ml of the water-based liquid was added, and the mixture was shaken, 5 In the second, even within 1 second, the emulsion can be formed, and the formed emulsion can be kept stable at room temperature for more than 5 minutes, and can be kept stable, and can be kept uniform and stable without delamination;
  • the hydrophilic lipid composition and the water-based liquid are poured into a mixing bottle, wherein the weight ratio of the water-based liquid having a water content of more than 60% to the hydrophilic lipid composition is greater than 3:1, preferably The weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 10:1, so that the total volume of the hydrophilic lipid composition and the water-based liquid does not exceed 70% of the capacity of the blending bottle, and the lid of the blending bottle is tightened.
  • the distance of the mixing bottle is not less than 10 cm each time, and
  • the mixed liquid moves to the remaining space of the mixing bottle, preferably, the mixed liquid is moved to the remaining space of the mixing bottle and impacts the cover of the mixing bottle, and a uniform emulsion is formed according to the above method, and the emulsion is allowed to stand at room temperature.
  • the emulsion is still uniform in 5 minutes, and no stratification occurs;
  • the mixing bottle can be a glass bottle with a lid, a plastic bottle with a lid, an aluminum-plastic paper box with a lid, and a metal container with a lid.
  • hydrophilic lipid composition containing the emulsifier and the liquid fat of any of the examples 7 and 4 to 4 is prepared by mixing with a water-based liquid and further shaking to form an emulsion.

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Abstract

L'invention concerne une composition d'emballage qui comporte une composition lipidique hydrophile et un liquide à base d'eau qui sont respectivement emballés individuellement et combinés ensemble. La composition lipidique hydrophile contient de la graisse liquide et un émulsifiant. La teneur en graisse liquide dans la composition lipidique hydrophile en termes de poids est supérieure à 45 %. La teneur en émulsifiant dans la composition lipidique hydrophile en termes de poids est de 0,05 % à 8 %. Le rapport de poids entre le liquide à base d'eau et la composition lipidique hydrophile est supérieur à 3:1. La somme des volumes du liquide à base d'eau et de la composition lipidique hydrophile n'est pas supérieure à 98 % du volume d'un récipient contenant le liquide à base d'eau. L'invention concerne également un procédé de mélange de la composition liquide hydrophile et du liquide à base d'eau en une émulsion, comprenant les étapes consistant : à verser la composition lipidique hydrophile et le liquide à base d'eau dans une bouteille de mélange et à secouer la bouteille de mélange au moins une fois dans une seconde bouteille, soit à la main, soit par un manipulateur. L'invention concerne des applications du procédé de mélange de la composition lipidique hydrophile et du liquide à base d'eau en émulsion dans la préparation ou le mélange d'un médicament, d'une formule alimentaire destinée à une utilisation médicale particulière, d'un produit alimentaire de soins de santé, d'un produit alimentaire nutritionnel ou d'un produit cosmétique.
PCT/CN2017/101851 2016-09-20 2017-09-15 Composition d'emballage de composition lipidique hydrophile, son procédé de préparation et de mélange et ses applications WO2018054265A1 (fr)

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