WO2018054265A1 - Hydrophilic lipid composition packaging composition, preparation and blending method for same, and applications thereof - Google Patents

Hydrophilic lipid composition packaging composition, preparation and blending method for same, and applications thereof Download PDF

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Publication number
WO2018054265A1
WO2018054265A1 PCT/CN2017/101851 CN2017101851W WO2018054265A1 WO 2018054265 A1 WO2018054265 A1 WO 2018054265A1 CN 2017101851 W CN2017101851 W CN 2017101851W WO 2018054265 A1 WO2018054265 A1 WO 2018054265A1
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Prior art keywords
liquid
lipid composition
fat
water
acid
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PCT/CN2017/101851
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French (fr)
Chinese (zh)
Inventor
雷凡琦
王保红
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张碧婷
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Publication of WO2018054265A1 publication Critical patent/WO2018054265A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/005—Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/005—Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
    • A23D7/0053—Compositions other than spreads
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/01—Other fatty acid esters, e.g. phosphatides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/01—Other fatty acid esters, e.g. phosphatides
    • A23D7/011—Compositions other than spreads
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/02—Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by the production or working-up
    • A23D7/04—Working-up
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/06—Preservation of finished products
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4993—Derivatives containing from 2 to 10 oxyalkylene groups
    • A—HUMAN NECESSITIES
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    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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    • A61K2800/10—General cosmetic use

Definitions

  • the present invention relates to a health product composition, in particular to a packaging composition of a hydrophilic lipid composition, a process for the preparation thereof, its use and application.
  • the health product composition according to the present invention includes a medicine, a special medical use formula food, a health food, a nutraceutical food, a cosmetic, etc., and specifically a composition containing an emulsifier and a liquid fat which does not contain water.
  • lipids including unsaturated fatty acids are completely incompatible with water.
  • the use of healthy nutrients is used at the same time.
  • the prior art is to prepare a lipid substance and a water-based liquid for use as an emulsion for a patient or a special population.
  • this pre-prepared emulsion maintains the stability and elongation of the emulsion.
  • a large amount or even an excess of emulsifier is added, and in order to maintain the stability of unsaturated fatty acids, a large amount of antioxidants, preservatives, and alkaline compounds such as sodium hydroxide are used to adjust the opacity.
  • the pH of the liquid which is not conducive to the oral absorption of fatty acids, and even poses a health hazard; in addition, unsaturated fatty acids and esters, such as linolenic acid, linoleic acid, oleic acid, arachidonic acid, conjugated linoleum Acid, conjugated linoleic acid glyceride, DHA, EPA, nervonic acid, etc. in the aqueous mixture, it is easy to oxidize and degrade, especially at temperatures above 40 °C, accelerate degradation, build Loss of a large number of unsaturated fatty acids, and seriously affect the quality and safety of the composition.
  • lipids especially unsaturated fatty acids, are very greasy and unacceptable when consumed directly; therefore, the prior art takes oral intake by making unsaturated fatty acids into soft capsules, which is not conducive to oral taking.
  • the convenience of access is also not conducive to large doses of oral intake, but also is not conducive to oral absorption.
  • Chinese Patent Publication Nos. CN104397702A, CN104490773A, and CN104397706A disclose an emulsion composition containing a phospholipid, another fat-soluble substance, and water, which forms a uniform emulsion of a fat-soluble substance and water by a high-speed stirring emulsification and a homogeneous processing process. Conducive to consumption and absorption.
  • the fat-soluble substance of unsaturated fatty acid is easily oxidized and degraded in an aqueous mixed solution, especially at a temperature above 40 ° C, which accelerates degradation, resulting in a large loss of unsaturated fatty acids, and is severe. Affect the quality and safety of the composition.
  • a non-aqueous lipid composition having good stability but a non-aqueous lipid composition is oily, completely incompatible with water and floating on the water surface, and stirring or shaking does not allow the lipid composition to The water is evenly mixed, which is extremely disadvantageous for the preparation of the lipid composition.
  • the scope of use thereof is severely limited, especially for the need to mix the lipid composition with the water agent uniformly, or need to It is very difficult to formulate a lipid composition into a nutrient food/special medical use formula which can be orally administered as a homogenized meal; and it is also necessary to satisfy the user's quick and easy formulation with a liquid agent, and to prepare a good mixture. It is an emulsion and is not easily visible to the naked eye, which is beneficial for consumption and use.
  • liquid fats that do not contain water should be satisfied when they are formulated into a product that is easy to be orally ingested with water-based liquids, especially in the practical application or clinical use of nutritional foods, special medical formulas, medicines, etc.
  • the emulsion formed by the water-based liquid has good stability and is not prone to obvious delamination, for example, no visible delamination occurs in at least 1 minute, so that the user has a longer drinking period. Or the time of oral intake;
  • the formed emulsion can form a uniform emulsion after slight swaying after standing to facilitate intermittent drinking or oral ingestion by the user.
  • the prior art cannot satisfy the above four conditions, and generally the use of the non-aqueous lipid composition into a soft capsule preparation is used, which greatly limits the consumer or the patient.
  • the demand for intake for example, for patients who cannot be swallowed and need enteral nutrition support, this soft capsule preparation cannot be ingested by the tube, and also limits the oral absorption and utilization of the fat-soluble substance.
  • An object of the present invention is to provide a lipid composition which has excellent hydrophilicity and which is rapidly dissolved in a water-based liquid to form an emulsion, and a method of blending the same.
  • the lipid composition has excellent hydrophilicity, which not only ensures the product quality of the lipid composition in production, storage and transportation, and shelf life, but also facilitates mixing and dissolving with the water-based liquid during use, and is convenient and quick. Use.
  • the present invention provides a hydrophilic lipid composition containing a liquid fat and an emulsifier, which is mixed with a water-based liquid and then shaken to form an emulsion. Further, the present invention also provides a packaging composition thereof, a preparation method, its formulation use and application.
  • the liquid fat of the present invention is defined as a fatty acid or fat which exhibits a liquid state at normal temperature and pressure, and includes a saturated or unsaturated fatty acid, a saturated or unsaturated fat, a triglyceride of a saturated or unsaturated fatty acid, a saturated or The diglyceride of the unsaturated fatty acid, for example, but not limited to, oleic acid, linoleic acid, linolenic acid, medium chain triglyceride, diglyceride, medium long chain fatty acid, and the like.
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, a fat-soluble substance A and a fat-soluble substance B, the emulsifier being selected from one or more of the following: phospholipids, sucrose fatty acid esters, single and double Glycerol fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty acid glyceride, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Division
  • the fat-soluble substance A is selected from the following one Or a variety of substances: oleic acid, linoleic acid, linolenic acid, medium chain triglycerides, diglycerides, medium and long
  • the linolenic acid includes ⁇ -linen Acid or gamma-linolenic acid, the medium long chain fatty acid comprising a medium chain fatty acid or a long chain fatty acid.
  • the fat-soluble substance A and the fat-soluble substance B of the present invention are both fatty acids or fat-soluble substances, usually extracted from vegetable oil or animal oil, or further extracted from vegetable oil or animal oil (such as fish oil, krill oil).
  • a resynthesized compound or fat for example, lecithin is extracted from soybean oil or egg yolk, and phosphatidylserine is produced by using lecithin and L-serine as a raw material, and is purified by a phospholipase conversion reaction;
  • Phytosterols include ⁇ -sitosterol, campesterol, stigmasterol, etc. extracted from soybean oil, rapeseed oil, corn oil, sunflower oil, and tallow oil;
  • the fat-soluble substance A or the fat-soluble substance B of the present invention is usually present in the oil and fat in a certain amount, and the fat-soluble substance A or the fat-soluble substance B of the present invention may also contain the above-mentioned A vegetable oil or animal oil of the fat-soluble substance A or the fat-soluble substance B, or a compound or fat which is further synthesized or fermented after being extracted from vegetable oil or animal oil is used in the present invention.
  • perilla seed oil, linseed oil, peony seed oil, cane fruit oil or eucommia seed oil having an ⁇ -linolenic acid content of more than 30% is used as a donor of ⁇ -linolenic acid, and is applied to the present invention
  • ⁇ -linolenic acid ⁇ -linolenic acid oil having a content of more than 8% is used as a donor of ⁇ -linolenic acid, and is applied to the present invention
  • medium-long-chain fatty acid edible oil contains more than 11% of medium-chain fatty acids and more than 10% of long-chain fatty acids
  • medium-long-chain fatty acid edible oil can be used as a medium-long-chain fatty acid, medium-chain fatty acid or long-chain fatty acid.
  • ingot ore oil having a lingonic acid content of 3% to 8% or a shark oil as a donor of nervonic acid is used in the present invention.
  • DHA algal oil having a DHA content of 3% to 6% is used as a donor of DHA, and is applied to the present invention
  • a fish oil or fish oil extract having a DHA content of 3% to 15% is used as a donor of DHA, and is applied to the present invention
  • Krill oil having a DHA content of more than 3% is used as a donor of DHA, and is applied to the present invention
  • soybean phospholipids for example, soybean phospholipids, krill oil, soy lecithin, egg yolk phospholipids, egg yolk lecithin with a total phospholipid content greater than 35% As a donor of phospholipids, it is used in the present invention.
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, a fat-soluble substance A, and a fat-soluble substance B, the emulsifier being selected from one or more of the following: a phospholipid, a sucrose fatty acid ester, Mono, diglycerin fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty acid glyceride, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80; wherein the content of the emulsifier is 0.05% to 8% by weight, preferably the content of the emulsifier is 0.1% to 6% by weight; the fat-soluble substance A is selected from the group consisting of Medium chain triglyceride and one or more of the following: oleic acid, linoleic acid, alpha-linolenic acid, gamma
  • the fat-soluble substance B is selected from one or more of the following substances: nervonic acid, DHA, EPA, peanut Tetraenoic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol,
  • the phosphatidylcholine wherein the content of the fat-soluble substance B is 0 to 30% by weight, preferably the content of the fat-soluble substance B is 0.01% to 30% by weight;
  • the medium-long chain fatty acid includes a medium chain Fatty acid or long-chain fatty acid, the emulsifier also includes various types, specifications, degree of polymerization, degree of esterification, mono/diester, or monomer components thereof, including lecithin, phosphatidylethanolamine, Phosphatidylinositol or phosphati
  • the content of the fat-soluble substance B is 0.01% to 30% by weight, preferably the content of the fat-soluble substance B is 0.05% to 25% by weight, and preferably the content of the fat-soluble substance B is 0.01 by weight. %, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4% 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1 %, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5%, 5.1%, 5.2%, 5.3%,
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, a fat-soluble substance A, and a fat-soluble substance B, the emulsifier being selected from one or more of the following: a phospholipid, a sucrose fatty acid ester, Mono, diglycerin fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty acid glyceride, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80, wherein the content of the emulsifier is 0.05% to 8% by weight;
  • the fat-soluble substance A is selected from the group consisting of linolenic acid and one or more of the following substances: oleic acid, sub Oleic acid, medium chain triglyceride, diglyceride, medium long chain fatty acid, wherein the content of linolenic acid in the
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, a fat-soluble substance A, and a fat-soluble substance B, the emulsifier being selected from one or more of the following: a phospholipid, a sucrose fatty acid ester, Mono, diglycerin fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty acid glyceride, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80, wherein the content of the emulsifier is 0.05% to 8% by weight;
  • the fat-soluble substance A is selected from the group consisting of linoleic acid and one or more of the following substances: oleic acid, ⁇ -linolenic acid, ⁇ -linolenic acid, medium-chain triglyceride, diglyceride, medium-long-chain
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, a fat-soluble substance A, and a fat-soluble substance B, the emulsifier being selected from one or more of the following: a phospholipid, a sucrose fatty acid ester, Mono, diglycerin fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty acid glyceride, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80, wherein the content of the emulsifier is 0.05% to 8% by weight;
  • the fat-soluble substance A is selected from the group consisting of oleic acid and one or more of the following substances: linoleic acid, ⁇ -linolenic acid, ⁇ -linolenic acid, medium chain triglyceride, diglyceride, medium long chain fatty acid,
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, a medium chain triglyceride, and a fat-soluble substance A, which is selected from the group consisting of oleic acid, linoleic acid, and ⁇ -linen.
  • an emulsifier a medium chain triglyceride
  • a fat-soluble substance A which is selected from the group consisting of oleic acid, linoleic acid, and ⁇ -linen.
  • the ratio is preferably 0.05% to 8%, preferably the content of the emulsifier is 0.1% to 6% by weight, and most preferably the emulsifier is 0.3% to 2.5% by weight
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, a medium chain triglyceride, and a fat-soluble substance B, the fat-soluble substance B being selected from the group consisting of nervonic acid, DHA, EPA, and arafflene.
  • the weight ratio is 0.1% to 6%, and the content of the fat-soluble substance B is 0.01% to 30% by weight, preferably the fat-soluble substance B The content is 0.05% to 25% by weight, and preferably the content of the fat-soluble substance B is 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09% by weight.
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, a nervonic acid, and a fat-soluble substance A, wherein the fat-soluble substance A is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and medium chain glycerin One or more of an ester, a medium long chain fatty acid, and a diglyceride, the content of the fat-soluble substance A is more than 45% by weight, and the content of the emulsifier is 0.05% to 8% by weight, preferably an emulsifier.
  • the fat-soluble substance A is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and medium chain glycerin
  • the content of the fat-soluble substance A is more than 45% by weight
  • the content of the emulsifier is 0.05% to 8% by weight, preferably an emulsifier.
  • the content is 0.1% to 6% by weight, and the content of the nerve acid is 0.01% to 30% by weight, and preferably the content of the nerve acid is 0.01%, 0.02%, 0.03%, 0.04% by weight.
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, DHA, and a fat-soluble substance A, which is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and medium chain triglyceride.
  • a fat-soluble substance A which is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and medium chain triglyceride.
  • the content of the fat-soluble substance A is more than 45% by weight
  • the content of the emulsifier is 0.05% to 8% by weight, preferably an emulsifier.
  • the content is 0.1% to 6% by weight
  • the content of DHA is 0.01% to 30% by weight, and preferably the content of DHA is 0.04% to 25% by weight.
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, EPA, and a fat-soluble substance A, which is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and medium chain triglyceride.
  • an emulsifier EPA
  • a fat-soluble substance A which is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and medium chain triglyceride.
  • the content of the fat-soluble substance A is more than 45% by weight
  • the content of the emulsifier is 0.05% to 8% by weight, preferably an emulsifier.
  • the content is 0.1% to 6% by weight, and the EPA content is 0.01% to 30% by weight.
  • the content of EPA is selected to be 0.04% to 25% by weight.
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, arachidonic acid, and a fat-soluble substance A, wherein the fat-soluble substance A is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and medium chain.
  • the content of the fat-soluble substance A is more than 45% by weight, and the content of the emulsifier is 0.05% to 8% by weight, preferably The content of the emulsifier is 0.1% to 6% by weight, the content of arachidonic acid is 0.01% to 30% by weight, and the content of arachidonic acid is preferably 0.04% to 25% by weight.
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, vitamin E, and a fat-soluble substance A, wherein the fat-soluble substance A is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and medium chain glycerin One or more of an ester, a medium long chain fatty acid, and a diglyceride, the content of the fat-soluble substance A is more than 45% by weight, and the content of the emulsifier is 0.05% to 8% by weight, preferably an emulsifier.
  • the content is 0.1% to 6% by weight, and the content of vitamin E is 0.01% to 30% by weight, and preferably the content of vitamin E is 0.04% to 25% by weight.
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, a conjugated linoleic acid, and a fat-soluble substance A, wherein the fat-soluble substance A is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and the like.
  • the fat-soluble substance A is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and the like.
  • One or more of chain triglyceride, medium long chain fatty acid, and diglyceride the content of the fat-soluble substance A is more than 45% by weight, and the content of the emulsifier is 0.05% to 8% by weight.
  • the content of the emulsifier is 0.1% to 6% by weight
  • the content of the conjugated linoleic acid is 0.01% to 25% by weight
  • the content of the conjugated linoleic acid is preferably 0.04% by weight. 20%.
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, a conjugated linoleic acid glyceride, and a fat-soluble substance A, which is selected from the group consisting of oleic acid, linoleic acid, and linolenic acid.
  • an emulsifier a conjugated linoleic acid glyceride
  • a fat-soluble substance A which is selected from the group consisting of oleic acid, linoleic acid, and linolenic acid.
  • One or more of medium chain triglyceride, medium long chain fatty acid, and diglyceride the content of the fat-soluble substance A is more than 45% by weight, and the content of the emulsifier is 0.05% to 8 by weight.
  • the content of the emulsifier is from 0.1% to 6% by weight
  • the content of the conjugated linoleic acid glyceride is from 0.01% to 25% by weight, preferably the content of the conjugated linoleic acid glyceride is by weight.
  • the ratio is 0.04% to 20%.
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, phosphatidylserine, and a fat-soluble substance A, which is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and medium chain glycerin.
  • a triester, a medium long chain fatty acid, and a diglyceride the content of the fat-soluble substance A is more than 45% by weight
  • the content of the emulsifier is 0.05% to 8% by weight, preferably emulsified.
  • the content of the agent is from 0.1% to 6% by weight
  • the content of phosphatidylserine is from 0.01% to 30% by weight
  • the content of phosphatidylserine is preferably from 0.04% to 25% by weight.
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, polyene phosphatidylcholine, and a fat-soluble substance A, wherein the fat-soluble substance A is selected from the group consisting of oleic acid, linoleic acid, and linolenic acid.
  • the fat-soluble substance A is selected from the group consisting of oleic acid, linoleic acid, and linolenic acid.
  • the content of the emulsifier is 0.1% to 6% by weight, and the content of polyene phosphatidylcholine is 0.01% to 25% by weight, preferably the content of polyene phosphatidylcholine is by weight. 0.04% to 25%.
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, phytosterol, and a fat-soluble substance A
  • the fat-soluble substance A is selected from one or more of oleic acid, linoleic acid, linolenic acid, medium chain triglyceride, medium long chain fatty acid, and diglyceride, and the content of the fat-soluble substance A is in terms of weight ratio. More than 45%, the content of the emulsifier is 0.05% to 8% by weight, preferably the content of the emulsifier is 0.1% to 6% by weight, and the content of phytosterol is 0.01% to 30% by weight. Preferably, the content of phytosterol is from 0.04% to 25% by weight.
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, a phytosterol ester, and a fat-soluble substance A, which is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and medium chain glycerin.
  • a triester, a medium long chain fatty acid, and a diglyceride the content of the fat-soluble substance A is more than 45% by weight
  • the content of the emulsifier is 0.05% to 8% by weight, preferably emulsified.
  • the content of the agent is from 0.1% to 6% by weight
  • the content of the phytosterol ester is from 0.01% to 30% by weight, preferably from 0.05% to 26% by weight of the phytosterol ester.
  • the present invention provides a hydrophilic lipid composition containing an emulsifier, a plant stanol ester, and a fat-soluble substance A, wherein the fat-soluble substance A is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and the like.
  • the fat-soluble substance A is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and the like.
  • One or more of chain triglyceride, medium long chain fatty acid, and diglyceride the content of the fat-soluble substance A is more than 45% by weight, and the content of the emulsifier is 0.05% to 8% by weight.
  • the content of the emulsifier is from 0.1% to 6% by weight, and the content of the plant stanol ester is from 0.01% to 30% by weight, preferably the content of the plant stanol ester is 0.04% by weight. 25%.
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising linolenic acid, an emulsifier, and a fat-soluble substance B, wherein the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, arachidonic acid, and vitamin E.
  • the linolenic acid includes ⁇ -linolenic acid or ⁇ -linolenic acid, wherein the content of linolenic acid is 45% to 99.5% by weight, and the content of the emulsifier is 0.05% by weight.
  • the content of the emulsifier is 0.3% to 2.5% by weight
  • the content of the fat-soluble substance B is 0.01% to 30% by weight, preferably the content of the fat-soluble substance B is 0.05% by weight.
  • the content of the fat-soluble substance B is 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.2%, 0.3 by weight.
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising linoleic acid, an emulsifier, and a fat-soluble substance B, wherein the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, and vitamins.
  • A vitamin D, conjugated linoleic acid, One or more of conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidylcholine, wherein linoleic acid is present
  • the weight ratio is 45% to 99%
  • the content of the emulsifier is 0.05% to 8% by weight, preferably the content of the emulsifier is 0.3% to 2.5% by weight
  • the content of the fat-soluble substance B is by weight.
  • the ratio of the fat-soluble substance B is preferably 0.04% to 25% by weight, and preferably the content of the fat-soluble substance B is 0.06% to 23% by weight.
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising oleic acid, an emulsifier, and a fat-soluble substance B, wherein the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, and vitamin A.
  • vitamin D conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidylcholine Or a plurality of, wherein the content of oleic acid is 45% to 99% by weight, the content of the emulsifier is 0.05% to 8% by weight, and preferably the content of the emulsifier is 0.3% to 2.5% by weight.
  • the content of the fat-soluble substance B is 0.01% to 30% by weight, and preferably the content of the fat-soluble substance B is 0.05% to 20% by weight.
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising medium chain triglyceride, an emulsifier, and a fat-soluble substance B, wherein the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, arachidonic acid, and vitamin E.
  • vitamin A vitamin D
  • conjugated linoleic acid conjugated linoleic acid glyceride
  • phosphatidylserine phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidylcholine
  • the content of the medium chain triglyceride is 40% to 99.5% by weight
  • the content of the emulsifier is 0.05% to 8% by weight
  • the content of the emulsifier is by weight
  • the content of the fat-soluble substance B is from 0.01% to 30% by weight, and the content of the fat-soluble substance B is preferably from 0.05% to 25% by weight.
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising a diglyceride, an emulsifier, and a fat-soluble substance B, wherein the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, and vitamins.
  • A vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidylcholine
  • the content of the diglyceride is 45% to 99% by weight
  • the content of the emulsifier is 0.05% to 8% by weight
  • the content of the emulsifier is preferably 0.3% by weight.
  • the content of the fat-soluble substance B is 0.01% to 30% by weight, and preferably the content of the fat-soluble substance B is 0.05% to 20% by weight.
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising a medium long chain fatty acid, an emulsifier, and a fat soluble substance B
  • the fat soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, Vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidylcholine
  • the content of the medium long chain fatty acid is 45% to 99% by weight
  • the content of the emulsifier is 0.05% to 8% by weight, and preferably the content of the emulsifier is 0.3 by weight.
  • % to 2.5% the content of the fat-soluble substance B is 0.01% to 30% by weight, and the content of the
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising oleic acid, linoleic acid, an emulsifier, and a fat-soluble substance B
  • the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol One or more of ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidylcholine, wherein the total content of oleic acid and linoleic acid is 45% to 99% by weight, emulsifier The content is 0.05% to 8% by weight, preferably the content of the emulsifier is 0.1% to 6% by weight, and the content of the fat-soluble substance B is 0.01%
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising linolenic acid, linoleic acid, an emulsifier, and a fat-soluble substance B, wherein the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, arachidonic acid, and vitamins.
  • E vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidylcholine
  • the total content of linolenic acid and linoleic acid is 45% to 99% by weight
  • the content of the emulsifier is 0.05% to 8% by weight
  • the content of the emulsifier is The weight ratio is from 0.1% to 6%
  • the content of the fat-soluble substance B is from 0.01% to 30% by weight, and preferably the content of the fat-soluble substance B is from 0.05% to 20% by weight.
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising linolenic acid, medium chain triglyceride, emulsifier, fat-soluble substance B, and the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, and arachidonic acid.
  • vitamin E vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidyl One or more of choline, wherein the total content of linolenic acid and medium chain triglyceride is 45% to 99% by weight, and the content of the emulsifier is 0.05% to 8% by weight, preferably emulsified
  • the content of the agent is from 0.1% to 6% by weight, and the content of the fat-soluble substance B is from 0.01% to 30% by weight, and preferably the content of the fat-soluble substance B is from 0.05% to 20% by weight.
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising linoleic acid, medium chain triglyceride, emulsifier, fat-soluble substance B, and the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, and arafflene.
  • Acid vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phospholipid
  • choline wherein the total content of linoleic acid and medium chain triglyceride is 45% to 99% by weight, and the content of emulsifier is 0.05% to 8% by weight.
  • the content of the emulsifier is 0.1% to 6% by weight
  • the content of the fat-soluble substance B is 0.01% to 30% by weight
  • the content of the fat-soluble substance B is 0.05% to 20% by weight.
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising medium chain triglyceride, linoleic acid, linolenic acid, an emulsifier, and a fat-soluble substance B
  • the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, Arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol,
  • One or more of polyene phosphatidylcholines wherein the total content of medium chain triglyceride, linoleic acid and linolenic acid is 45% to 99% by weight, and the content of emulsifier is by weight 0.05% to 8%, preferably the content of the emul
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising medium chain triglyceride, linolenic acid, linoleic acid, oleic acid, emulsifier, fat-soluble substance B, and the fat-soluble substance B is selected from the group consisting of nervonic acid and DHA.
  • EPA arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fat
  • an alkanol or a polyene phosphatidylcholine wherein the total content of medium chain triglyceride, linolenic acid, linoleic acid and oleic acid is 45% to 99% by weight, and the emulsifier is The content is 0.05% to 8% by weight, preferably the content of the emulsifier is 0.1% to 6% by weight, and the content of the fat-soluble substance B is 0.01% to 30% by weight, preferably the fat-soluble substance B. The content is 0.05% to 20% by weight.
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising medium chain triglyceride, medium long chain fatty acid, emulsifier, fat soluble substance B, and the fat soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, and peanut.
  • Acrylic acid vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene
  • phosphatidylcholines wherein the total content of medium chain triglyceride and medium long chain fatty acid is 45% to 99% by weight, and the content of emulsifier is 0.05% to 8 by weight.
  • % preferably, the content of the emulsifier is 0.1% to 6% by weight, the content of the fat-soluble substance B is 0.01% to 30% by weight, and the content of the fat-soluble substance B is preferably 0.05% by weight. 20%.
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising medium chain triglyceride, diglyceride, emulsifier, fat-soluble substance B, and the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, and arafflene.
  • Acid vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phospholipid
  • choline wherein the total content of medium chain triglyceride and diglyceride is 45% to 99% by weight, and the content of emulsifier is 0.05% to 8% by weight.
  • the content of the emulsifier is preferably from 0.1% to 6% by weight, and the content of the fat-soluble substance B is from 0.01% to 30% by weight.
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising linolenic acid, diglyceride, an emulsifier, and a fat-soluble substance B, wherein the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, arachidonic acid, and vitamins.
  • E vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidylcholine
  • the total content of linolenic acid and diglyceride is 45% to 99% by weight
  • the content of the emulsifier is 0.05% to 8% by weight
  • the content of the emulsifier is The weight ratio is from 0.1% to 6%
  • the content of the fat-soluble substance B is from 0.01% to 30% by weight, and preferably the content of the fat-soluble substance B is from 0.05% to 20% by weight.
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising diglyceride, linoleic acid, an emulsifier, and a fat-soluble substance B
  • the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, arachidonic acid, Vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidylcholine
  • One or more of the bases wherein the total content of the diglyceride and the linoleic acid is 45% to 99% by weight, and the content of the emulsifier is 0.05% to 8% by weight, preferably an emulsifier Content by weight
  • the content of the fat-soluble substance B is from 0.01% to
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising diglyceride, linoleic acid, linolenic acid, an emulsifier, and a fat-soluble substance B, wherein the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, and peanut.
  • Acrylic acid vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene
  • phosphatidylcholine wherein the total content of diglyceride, linoleic acid and linolenic acid is 45% to 99% by weight, and the content of emulsifier is 0.05% to 8 by weight.
  • % preferably, the content of the emulsifier is 0.1% to 6% by weight, the content of the fat-soluble substance B is 0.01% to 30% by weight, and the content of the fat-soluble substance B is preferably 0.05% by weight. 20%.
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising a medium long chain fatty acid, a diglyceride, an emulsifier, a fat soluble substance B, and the fat soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, and arachidonic acid.
  • vitamin E vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidyl One or more of choline, wherein the total content of the medium long chain fatty acid and the diglyceride is 45% to 99% by weight, and the content of the emulsifier is 0.05% to 8% by weight, preferably emulsified.
  • the content of the agent is from 0.1% to 6% by weight, and the content of the fat-soluble substance B is from 0.01% to 30% by weight, and preferably the content of the fat-soluble substance B is from 0.05% to 20% by weight.
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising linolenic acid, a medium long chain fatty acid, an emulsifier, and a fat soluble substance B
  • the fat soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, arachidonic acid, Vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidylcholine
  • the bases wherein the total content of the linolenic acid and the medium long-chain fatty acid is 45% to 99% by weight, and the content of the emulsifier is 0.05% to 8% by weight, preferably an emulsifier The content is 0.1% to 6% by weight, and the content of the fat
  • the present invention provides a hydrophilic lipid composition
  • a hydrophilic lipid composition comprising linoleic acid, a medium long chain fatty acid, an emulsifier, a fat soluble substance B, and the fat soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, and arachidonic acid.
  • vitamin E vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidyl
  • choline wherein the total content of linoleic acid and medium long-chain fatty acid is 45% to 99% by weight, and the content of emulsifier is 0.05% to 8% by weight, preferably emulsified
  • the content of the agent is from 0.1% to 6% by weight, and the content of the fat-soluble substance B is from 0.01% to 30% by weight, and preferably the content of the fat-soluble substance B is from 0.05% to 20% by weight.
  • the emulsifier of the present invention is selected from one or more of the following: phospholipids, sucrose fatty acid esters, mono-, diglycerin fatty acid esters, polyglycerol fatty acid esters, propylene glycol fatty acid esters, lactic acid fatty acid glycerides, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80; the content of emulsifier is by weight 0.05% to 8%, preferably the content of the emulsifier is 0.1% to 6% by weight;
  • the content of the emulsifier is 0.07% to 7% by weight
  • the content of the emulsifier is 0.1% to 6% by weight;
  • the content of the emulsifier is 0.2% to 5% by weight
  • the content of the emulsifier is 0.3% to 4% by weight;
  • the content of the emulsifier is 0.4% to 3.5% by weight
  • the content of the emulsifier is 0.5% to 3% by weight
  • the content of the emulsifier is 0.6% to 2.5% by weight
  • the content of the emulsifier is 0.75% to 2% by weight;
  • the content of the emulsifier is 0.8% to 1.8% by weight
  • the content of the emulsifier is 0.85% to 1.7% by weight
  • the content of the emulsifier is 0.9% to 1.6% by weight
  • the content of the emulsifier is 0.95% to 1.5% by weight
  • the content of the emulsifier is 1.0% to 1.4% by weight;
  • the content of the emulsifier is 0.4% to 1.6% by weight;
  • the content of the emulsifier is 0.5% to 1.5% by weight
  • the content of the emulsifier is 0.6% to 1.4% by weight;
  • the content of the emulsifier is 0.7% to 1.3% by weight;
  • the content of the emulsifier is from 0.8% to 1.2% by weight.
  • the emulsifier further includes various types, specifications, degrees of polymerization, degree of esterification, mono/diester, or monomer components thereof.
  • the phospholipids include, but are not limited to, lecithin, phosphatidylethanolamine, phosphatidylinositol or phosphatidylglycerol.
  • the content of lecithin (ie, phosphatidylcholine) in the phospholipid is greater than 40%, preferably The content of lecithin in the phospholipid is greater than 50%; preferably, the content of lecithin in the phospholipid is greater than 60%;
  • the sucrose fatty acid esters include, but are not limited to, various models of S-1 to S-16;
  • single, double glycerol Fatty acid esters include, but are not limited to, glyceryl monostearate, mono, diolein, mono, dilauric glyceride, mono, bis linoleate, mono, linolenic glyceride, single , dipalmitin, mono, bis-capric glyceride;
  • polyglycerol fatty acid esters including, but not limited to, polyglyceryl stearate, polyglyceryl oleate, polyglyceryl laurate, polyglyceryl myristate Or dimers,
  • the emulsifier is a phospholipid, wherein the content of the phospholipid is 0.2% to 3.5% by weight, preferably the content of the phospholipid is 0.5% to 2.5% by weight.
  • the emulsifier is selected from the group consisting of phospholipids and one or more of the following: sucrose fatty acid esters, mono-, diglycerin fatty acid esters, polyglycerol fatty acid esters, propylene glycol fatty acid esters, lactic acid fatty acid glycerides, spit Temperature 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80; the content of emulsifier is 0.1% to 4% by weight. Preferably, the content of the emulsifier is from 0.2% to 3% by weight.
  • the emulsifier comprises a sucrose fatty acid ester and one or more of the following: phospholipid, mono-, diglycerin fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty acid glyceride, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80; the content of emulsifier is 0.06% to 5% by weight.
  • the content of the emulsifier is preferably from 0.3% to 3% by weight.
  • the emulsifier comprises a mono-, diglycerin fatty acid ester and one or more of the following: phospholipids, sucrose fatty acid esters, polyglycerol fatty acid esters, propylene glycol fatty acid esters, lactic acid fatty acid glycerides, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80; the content of emulsifier is 0.06% to 5% by weight.
  • the content of the emulsifier is preferably from 0.3% to 3% by weight.
  • the emulsifier comprises a polyglycerol fatty acid ester and one or more of the following: phospholipid, sucrose fatty acid ester, mono-, diglycerin fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty acid glyceride, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80; the content of emulsifier is 0.06% to 5% by weight.
  • the content of the emulsifier is preferably from 0.3% to 3% by weight.
  • the emulsifier comprises a propylene glycol fatty acid ester and one or more of the following: phospholipids, sucrose fatty acid esters, polyglycerol fatty acid esters, mono-, diglycerin fatty acid esters, lactic acid fatty acid glycerides, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80; the content of emulsifier is 0.06% to 5% by weight.
  • the content of the emulsifier is preferably from 0.3% to 3% by weight.
  • the emulsifier comprises lactic acid fatty acid glyceride and one or more of the following: phospholipid, sucrose fatty acid ester, polyglycerin fatty acid ester, mono, diglycerin fatty acid ester, propylene glycol fatty acid ester, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80; emulsifier content by weight ratio
  • the content of the emulsifier is preferably from 0.3% to 3% by weight, and is preferably from 0.3% to 3% by weight.
  • the content of the emulsifier of the present invention is 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6% by weight, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2% , 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9 %, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5%, 5.1%, 5.2%, 5.3%, 5.4%, 5.5%, 5.6%, 5.7%, 5.8%, 5.9%, 6%, 6.1%, 6.2%, 6.3%, 6.4%, 6.5%, 6.6%, 6.7%, 6.8%, 6.9%, 5%, 5.1%
  • the phospholipid of the present invention preferably the lecithin (ie phosphatidylcholine) in the phospholipid is greater than 40%, preferably the lecithin in the phospholipid is greater than 50%; preferably the lecithin in the phospholipid The content is more than 60%.
  • lecithin ie phosphatidylcholine
  • the phospholipid is selected from the group consisting of soybean phospholipids, soy lecithin, egg yolk phospholipids, egg yolk lecithin or krill oil.
  • hydrophilic lipid composition of the present invention may further contain other one or more functional ingredients, such as, but not limited to, lutein, lutein ester, coenzyme Q10, carotene, astaxanthin. , lycopene, soy isoflavones, plant extracts or propolis.
  • lutein lutein ester
  • coenzyme Q10 carotene
  • astaxanthin. lycopene
  • soy isoflavones plant extracts or propolis.
  • a special krill oil having a lipidated astaxanthin content of more than 500 mg/kg can be used as a donor fat of astaxanthin in the hydrophilic lipid composition of the present invention.
  • hydrophilic lipid composition of the present invention may further contain taste-improving ingredients such as, but not limited to, flavors or flavors, sweeteners such as stevioside, glycyrrhizin, trichloro Sucrose, and so on.
  • taste-improving ingredients such as, but not limited to, flavors or flavors, sweeteners such as stevioside, glycyrrhizin, trichloro Sucrose, and so on.
  • the hydrophilic lipid composition of the invention has excellent hydrophilicity, and can vibrate in a water-based liquid to rapidly form a uniform and stable emulsion;
  • the hydrophilic lipid composition of the present invention has excellent hydrophilicity, and it can rapidly form a uniform and stable emulsion by shaking in a water-based liquid containing ethanol.
  • the water-based liquid of the present invention comprises water, a liquid having a water content of more than 60%, or an aqueous solution containing ethanol.
  • the vibration of the present invention refers to a movement of a mixture which causes rapid flow, tumbling or/and impact impact in a container by vibration, shaking or shaking, including the user shaking the mixture by hand, or Machine operation is used to oscillate the mixture, for example by robotic operation.
  • the liquid fat of the present invention comprises a fatty acid or fat which exhibits a liquid state at normal temperature and pressure, preferably comprising a saturated or unsaturated fatty acid, a saturated or unsaturated fat, a triglyceride of a saturated or unsaturated fatty acid, a saturated or Diglycerides of unsaturated fatty acids include, for example, but are not limited to, oleic acid, linoleic acid, alpha-linolenic acid, gamma-linolenic acid, medium chain triglycerides, diglycerides, medium long chain fatty acids, and the like.
  • Emulsion is a complex, thermodynamically stable system, especially different oil types or fat-soluble components, due to The lipid-water distribution and binding energy state of each component are different, which is crucial for the stability of the whole system.
  • the multi-component milk system is prone to instability such as fat floating, flocculation or delamination.
  • the production method and process determine the shape and size of the fat globule in the emulsion, and whether microscopic phenomena such as aggregation occur, which affects the instability of the fat floating, flocculation or stratification of the emulsion on the macroscopic level, and also affects The absorption, absorption and utilization of the emulsion by the human body.
  • the environment may be turbid for a long time at a normal temperature or slightly lower than the normal temperature.
  • the phospholipid may precipitate and seriously affect the quality of the product.
  • the inventors have studied that the reason for this phenomenon is that the emulsifier is not easily blended with vegetable oils, for example, the freezing point of phospholipids is higher than the freezing point of vegetable oil, so that phospholipids that cannot be blended with vegetable oil will be at a temperature lower than the freezing point thereof. The precipitate precipitates, causing the oil to become cloudy, or the phospholipids will precipitate.
  • the preparation method of the hydrophilic lipid composition of the present invention is crucial, and the inventors have found that the emulsifier and the vegetable oil are blended and miscible by heating and high-speed mixing, so that the distribution is uniform and further rapid, Precise cooling, or oil-gas-miscible composition, when the emulsifier molecules are rapidly cooled, the emulsifier molecules will form a small molecule microcrystalline colloidal solution in a highly dispersed state, achieving a stable emulsifier and vegetable oil. Mixed.
  • the present invention provides a preparation method of the above hydrophilic lipid composition, which comprises:
  • the oily liquid is vacuum degassed, filled, sealed, packaged and inspected to obtain the hydrophilic lipid composition of the present invention.
  • the hydrophilic lipid composition prepared by the above method of the present invention is usually a pale yellow to dark yellow transparent oil. Further, the hydrophilic lipid composition and the water-based liquid are blended into an emulsion by shaking.
  • the affinity and dispersibility with the water-based liquid are critical, and the inventive method for preparing an oil-gas miscible composition for an emulsifier Blending is produced in the liquid fat and has a good effect on the hydrophilicity of the lipid composition.
  • the present invention provides a second preparation method of a hydrophilic lipid composition, which comprises:
  • the hydrophilic lipid composition prepared by the above method of the present invention is a foam-type oily substance containing nitrogen gas, which exhibits a non-transparent shape, and it is visually observed that fine or uniform bubbles are contained therein, or the liquid fat or oil exhibits a foamy shape. Further, the hydrophilic lipid composition and the water-based liquid are blended into an emulsion by shaking.
  • the present invention provides a method for preparing a third of the hydrophilic lipid composition, which comprises:
  • emulsifier a mixture of the emulsifier and the emulsifier 3 to 7 times the weight of the fat-soluble substance prepared in (2), placed in an emulsification tank, continuously passed into the oily liquid or kept emulsified
  • the pressure in the tank is stronger than 1.3 atm, and is stirred at a stirring speed of more than 300 r/min, so that the oily liquid exhibits a non-transparent nitrogen-rich foam-like oily liquid, or the oil is foamy, and the stirring is stopped;
  • the present invention provides a hydrophilic lipid composition comprising an emulsifier and a liquid fat, which is characterized by being produced by the above first preparation method, the second preparation method or the third preparation method.
  • the present invention provides a foam type hydrophilic lipid composition
  • the emulsifier being selected from the group consisting of the following Or a variety of substances: phospholipids, sucrose fatty acid esters, mono-, diglycerin fatty acid esters, polyglycerol fatty acid esters, propylene glycol fatty acid esters, lactic acid fatty acid glycerides, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80, wherein the content of the emulsifier is 0.05% to 8% by weight;
  • the fat-soluble substance A is selected from the following one Or a plurality of substances: oleic acid, linoleic acid, linolenic acid, medium chain triglyceride, diglyceride, medium and long chain fatty acid, wherein
  • the hydrophilic lipid composition provided by the present invention can rapidly form an emulsion by shaking in a water-based liquid, for example, by the operation of shaking, the hydrophilicity of the present invention.
  • the lipid composition is mixed with the water-based liquid in a closed container, for example, in a beverage bottle closed with a cap, the total volume of the hydrophilic lipid composition and the water-based liquid in the container is not higher than the total capacity of the container.
  • the lipid composition of the present invention and the water-based liquid can form an emulsion immediately, and the emulsion is allowed to stand for 5 minutes or even 10 minutes.
  • the uniform and stable emulsion is maintained, which greatly facilitates the preparation and consumption of the consumer or the patient; in addition, the hydrophilic lipid composition is formulated with the water-based liquid to form an emulsion, even after a long period of time. After standing and stratifying, it can be dispersed into an emulsion after slight shaking, and does not affect drinking or eating.
  • the inventors have described the process or technique of instantaneously forming an emulsion by a lipid composition provided by the present invention and a water-based liquid under the action of shaking, which is called "oil-water instantaneous mixing".
  • the present invention provides a method for using a hydrophilic lipid composition containing an emulsifier and a liquid fat, which comprises adding a hydrophilic lipid composition to a water-based liquid and shaking it to form an opacity.
  • a liquid for example, a method of using a product for nutritional treatment such as drinking oil or drinkable health oil;
  • the present invention provides a method of using the hydrophilic lipid composition comprising mixing the hydrophilic lipid composition of the present invention with a water-based liquid in a closed container. Shake it to make it an emulsion;
  • the water-based liquid comprises water, a liquid having a water content of more than 60%, or an aqueous solution containing ethanol; the shaking, preferably at least one shaking time in one second, and the shaking time is not Less than 1 second.
  • the present invention provides a method for mixing and mixing a hydrophilic lipid composition containing an emulsifier and a liquid fat with a water-based liquid, comprising shaking a mixture of a lipid composition and a water-based liquid to form an opacifier.
  • the liquid, the water-based liquid includes water, a liquid having a water content of more than 60%, or an aqueous solution containing ethanol.
  • the hydrophilic lipid composition containing an emulsifier and a liquid fat provided by the present invention has rapid water emulsification performance, and the hydrophilic lipid composition of the present invention is preferably formulated into an opacity using a blending bottle.
  • Liquid in particular, as a method for rapidly formulating a hydrophilic lipid composition with a water-based liquid into an aqueous emulsion by pouring a hydrophilic lipid composition and a water-based liquid into a mixing bottle, wherein
  • the weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 3:1, preferably the weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 10:1, such that the hydrophilic lipid composition and water
  • the total volume of the base liquid does not exceed 98% of the capacity of the blending bottle. Tighten the lid of the blending bottle and shake the blending bottle at least once in 1 second by hand or robot to shake the blending bottle for no more than 10 seconds.
  • the mixing bottle is shaken for no more than 5 seconds.
  • the distance of the mixing bottle is not less than 10 cm per movement, and the mixture is moved to the remaining space of the mixing bottle, preferably the mixing solution is adjusted to the bottle.
  • the remaining space moves and impacts the cover of the bottle , a uniform emulsion can be formed, which is allowed to stand at room temperature for 5 minutes to maintain a uniform emulsion state without delamination;
  • the dispensing bottle includes a glass bottle with a lid, a plastic bottle with a lid, Aluminum-plastic carton with lid, metal container with lid, for example, polymer PET bottle, high-density polyethylene bottle, etc.; preferably, the volume of the bottle is not more than 3 liters, and most preferably the volume of the bottle is not more than 3 liters, preferably volume of 2.5 liter, 1.5 liter, 1 liter, 0.9 liter, 0.8 liter, 0.7 liter, 0.6 liter, 0.5 liter, 0.45 liter, 0.4 liter,
  • the hydrophilic lipid composition containing the emulsifier and the liquid fat of the invention has unexpected rapid water emulsification performance, and brings great convenience and novelty to its use.
  • the hydrophilic lipid composition of the present invention can be rapidly and instantaneously dispersed in water by shaking, and has a property of being fast and hydrophilic. Further, the present invention provides a technical solution for rapidly formulating the hydrophilic lipid composition into an emulsion.
  • a hydrophilic lipid composition comprising an emulsifier, a fat-soluble substance A and a fat-soluble substance B, the emulsifier being selected from one or more of the following: a phospholipid, a sucrose fatty acid ester, a single, a double glycerin Fatty acid esters, polyglycerol fatty acid esters, propylene glycol fatty acid esters, lactic acid fatty acid glycerides, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80, wherein the content of the emulsifier is 0.05% to 8% by weight, preferably the content of the emulsifier is 0.1% to 6% by weight; the fat-soluble substance A is selected from the following one Or a plurality of substances: oleic acid, linoleic acid, ⁇ -linolenic acid, ⁇ -linolenic acid, medium chain trig
  • the fat-soluble substance B is selected from one or more of the following: nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleum Acid glycerides, phosphatidylserine, phytosterols, phytosterol esters, plant stanol esters, rice bran fatty alkanols, The phosphatidylcholine, wherein the content of the fat-soluble substance B is 0 to 30% by weight, characterized in that the hydrophilic lipid composition and the water-based liquid are oscillated by shaking, and can be formed within 5 seconds.
  • Emulsion and the formed emulsion is allowed to stand for at least 1 min to maintain uniformity In the emulsion state, no delamination occurs, wherein the weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 3:1, preferably the weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 10: 1;
  • the water-based liquid comprises: water, a liquid having a water content of more than 60%, or an aqueous solution containing ethanol;
  • the vibration refers to a movement, a tumbling or/and a collision impact of the mixture in the container by vibration, shaking or shaking, including shaking the mixture by the user by hand, or using a machine operation.
  • the mixture is shaken, for example by the operation of a robot.
  • the speed of the shaking is preferably a frequency at which at least one shaking occurs in one second;
  • the medium long chain fatty acid comprises a medium chain fatty acid or a long chain fatty acid
  • the content of the fat-soluble substance B is 0.01% to 30% by weight;
  • hydrophilic lipid composition and the water-based liquid are shaken to form an emulsion within 4 seconds;
  • hydrophilic lipid composition and the water-based liquid are shaken to form an emulsion within 3 seconds;
  • hydrophilic lipid composition and the water-based liquid are shaken to form an emulsion within 2 seconds;
  • hydrophilic lipid composition and the water-based liquid are shaken to form an emulsion within one second.
  • the hydrophilic lipid composition of the present invention belongs to a fat type composition, and the hydrophilic lipid composition of the present invention forms an emulsion in a water-based liquid for convenient use and better absorption. very necessary.
  • the present invention provides the hydrophilic lipid composition as a health food or beverage companion for various water-based liquid foods, preferably as a homogenate diet, milk, beverage, aqueous solution, juice, coffee, liquid food, Such as porridge, rice paste, batter, brewed food, such as brewed cereal, brewed milk powder, brewed coffee, brewed solid beverage, etc.; preferably used as a blending oil for drinking water, drinkable healthy oil; It is preferred to use a water-based liquid formulated into an emulsion.
  • the present invention further provides a packaging composition comprising the hydrophilic lipid composition of the present invention and a water-based liquid, the method of which the packaging composition is formulated into an emulsion.
  • a packaging composition comprising separately packaging and combining a hydrophilic lipid composition and a water-based liquid, the hydrophilic lipid composition comprising a liquid fat and an emulsifier, wherein the liquid fat is selected from the group consisting of One or more substances: medium chain triglyceride, ⁇ -linolenic acid, ⁇ -linolenic acid, diglyceride, oleic acid, linoleic acid, medium and long-chain fatty acid, liquid fat in hydrophilic lipid composition The content is greater than 45% by weight;
  • the emulsifier is selected from one or more of the following: phospholipids, sucrose fatty acid esters, mono-, diglycerin fatty acid esters, polyglycans Oil fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty acid glyceride, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80
  • the content of the emulsifier in the hydrophilic lipid composition is 0.05% to 8% by weight;
  • the water-based liquid is selected from the group consisting of water, a liquid having a water content of more than 60%, or an aqueous solution containing ethanol;
  • the weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 3:1;
  • the sum of the volume of the water-based liquid and the hydrophilic lipid composition is not more than 98% of the capacity of the container containing the water-based liquid.
  • the hydrophilic lipid composition further contains a fat-soluble substance B selected from one or more of the following substances: nervonic acid, DHA, EPA, and arafflene.
  • Acid vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phospholipid
  • the choline is a content of the fat-soluble substance B in the hydrophilic lipid composition in an amount of from 0.01% to 30% by weight.
  • hydrophilic lipid composition of various combinations, specific components, ratios, preparation methods, and formulation methods provided by the present invention are all applicable to the hydrophilic lipid composition of the above-mentioned packaging composition.
  • the packaging composition comprises separately packaging and combining the hydrophilic lipid composition of the present invention and a water-based liquid, for example, forming a combination in the same package or packaging, or, for example, a fat
  • Individual packaging of the composition of the composition and individual packaging of the water-based liquid are combined together in the form of a affixing, labeling or packaging kit to form a packaging composition, which is "combined by means of adhesive fastening, label fixing or packaging kit" ", means that the individual packaging of the lipid composition is combined with the independent packaging of the water-based liquid by means of tape or adhesive glue; or the product label of the lipid composition, the product label of the water-based liquid, through the label Bundling, wrapping, winding, etc., combining the individual packaging of the lipid composition with the independent packaging of the water-based liquid; or the independent packaging of the lipid composition and the independent packaging of the water-based liquid into a packaging package , put together, for example, a groove is formed in the container of the water-based liquid, and the package
  • the lid member of the container When in use, the lid member of the container is opened, the lipid composition in the lid member is released, mixed with the water-based liquid in the container, and further, uniformity is formed by shaking.
  • the emulsion for example, the cover member of the container can be referred to a technical solution similar to that disclosed in International Publication WO2007/129126.
  • the packaging composition comprises separately packaging the hydrophilic lipid composition of the present invention and presenting it in the same package unit simultaneously with the dispensing bottle, the dispensing bottle being empty with a lid
  • the bottle preferably the adjustment bottle, is marked with a scale line for the amount of water-based liquid to be added.
  • the water-based liquid is further added to facilitate the preparation and shaking, so that the fatty acid composition can be well formed into a uniform emulsion in the water-based liquid, and the user can also decide to add the hydrophilic lipid.
  • the packaging composition may be free of the blending bottle, but the label of the packaging of the hydrophilic lipid composition is marked with the combination of the lipids.
  • the content of the emulsion is obtained by mixing the mixture with the water-based liquid and shaking the mixture, and is also the technical content of the packaging composition of the lipid composition of the present invention, that is, the hydrophilic lipid composition.
  • the product label is marked with the content of the hydrophilic lipid composition mixed with the water-based liquid and obtained by shaking to obtain an emulsion.
  • the above packaging composition is more convenient for the combination and storage of the lipid composition and the water-based liquid, and is more advantageous for the preparation of the lipid composition and the water-based liquid, and the hydrophilic lipid composition is mixed with the water-based liquid.
  • the method for forming an emulsion comprises: pouring a hydrophilic lipid composition into a container containing a water-based liquid, wherein a weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 3:1, so that the pro The total volume of the aqueous lipid composition and the water-based liquid does not exceed 98% of the container capacity. Tighten the lid of the container and shake the container at least once in 1 second by hand or robot to shake the container.
  • the container when the container is shaken, the container is displaced by a distance of not less than 10 cm each time, and the mixed liquid is moved to the remaining space of the container to form an emulsion, preferably, when the container is shaken, the mixed solution is directed to the container.
  • the remaining space moves and impacts the cover of the bottle;
  • hydrophilic lipid composition comprises any of the hydrophilic lipid compositions of the present invention.
  • the water-based liquid is selected from the group consisting of water, a liquid having a water content of more than 60%, or an aqueous solution containing ethanol;
  • the water-based liquid container is selected from the group consisting of a glass bottle with a lid, a plastic bottle with a lid, an aluminum-plastic paper box with a lid, a metal container with a lid, and a container having a volume of no more than 3 liters.
  • the water-based liquids of the present invention include, but are not limited to, water, aqueous solutions of carbohydrates (eg, monosaccharides, disaccharides, oligosaccharides, polysaccharides, etc.), aqueous solutions of dietary fibers (eg, inulin, oligofructose, Polydextrose), aqueous suspension of dietary fiber, aqueous solution of amino acid, aqueous solution of vitamins, aqueous solution of electrolyte (such as aqueous solution of potassium chloride or magnesium sulfate), aqueous solution or suspension of probiotics, animal emulsion (such as milk, Milk emulsion of goat milk, horse milk), animal protein powder (such as milk powder, water emulsion of goat milk powder, water emulsion of refined milk protein powder), water emulsion of vegetable protein powder (soy protein An aqueous emulsion of powder, peanut protein powder), liquid fruit juice, liquid vegetable juice, water extract, etc
  • the water-based liquid of the present invention is selected from the group consisting of an aqueous solution of one or more of the following: sucrose, glucose, fructose, maltose, chitooligosaccharide, oligofructose, xylooligosaccharide, polydextrose, inulin, Taurine, cysteine, cystine, glycine, aspartic acid, asparagine, glutamic acid, glutamine, lysine, arginine, ornithine, vitamin C, vitamin B, L-carnitine, folic acid, nicotinic acid, choline, inositol; or, preferably, the water-based liquid of the present invention is selected from the group consisting of an animal emulsion, an aqueous emulsion of animal protein powder or an aqueous emulsion of vegetable protein powder.
  • the above water-based liquid on the one hand, not only provides water-soluble or protein-based nutrients, but also provides the pros provided by the present invention.
  • the aqueous lipid composition has a nutritional synergistic pharmacological effect.
  • the above water-based liquid is more advantageous for rapidly forming an emulsion with a hydrophilic lipid composition under the action of vibration, and maintaining good and not easy to stratify. The stability of the emulsion.
  • the present invention also provides the hydrophilic lipid composition for use in medicine, special medical use formula, health food, nutraceutical or cosmetic, etc.
  • the hydrophilic lipid composition contains
  • the unsaturated fatty acid and fat health component for rejuvenating human health and disease are especially suitable for preparing medicine, special medical use formula, health food, nutritious food or cosmetics, and on the other hand, the hydrophilic lipid combination of the present invention
  • the substance is in the form of a liquid, and can be used as a solvent for oils and fats, and is soluble in a fat-soluble drug, and can be further formulated and dispersed in a water-based liquid to form an emulsion, thereby facilitating oral administration, absorption and utilization of a fat-soluble drug.
  • fat-soluble drugs include adefovir dipivoxil, tenofovir, lutein, coenzyme Q10, and the like.
  • it when used in cosmetics, it is used as an emollient oil, skin care essential oil, hair care essential oil, or dissolved in water as a hydrating and oil replenishing agent for the face and skin, as well as skin nutrient oil, etc., for skin care.
  • the hydrophilic lipid composition of the present invention can be used as a drinking and blending oil, and can be used for health, health care, and nutritional treatment of health oil.
  • the present invention also provides a hydrophilic lipid composition containing the emulsifier and liquid fat by mixing with a water-based liquid and further oscillating to prepare an emulsion, in the preparation or formulation of a drug, special medicine Uses in formulas, health foods, nutraceuticals or cosmetics, especially in the preparation or deployment of immediate oral intake medications, special medical use formulas, health foods, nutraceuticals, or in the preparation or deployment of ready-to-use
  • the application in cosmetics is very convenient for the user to immediately deploy and use.
  • the present invention also provides an application of a hydrophilic lipid composition containing an emulsifier and a liquid fat by mixing with a water-based liquid to prepare an emulsion by shaking.
  • the invention also provides a homogenate diet for preparing a special medical use formula food by mixing a hydrophilic lipid composition containing an emulsifier and a liquid fat with a water-based liquid and further oscillating to form an emulsion.
  • a hydrophilic lipid composition containing an emulsifier and a liquid fat with a water-based liquid and further oscillating to form an emulsion.
  • the present invention also provides a hydrophilic lipid composition containing an emulsifier and a liquid fat, which is prepared by mixing with a water-based liquid and being shaken to prepare an emulsion, and is further used for the production of meals, using opacity.
  • Liquid instead of water in the production of meals is used in the production of meals, including but not limited to the application of steamed food, cooked food, prepared flour, mixed foods or prepared foods and beverages.
  • the hydrophilic lipid composition of the present invention can provide unsaturated fatty acids beneficial to the treatment of human health and diseases, such as nervonic acid, ⁇ -linolenic acid, ⁇ -linolenic acid, DHA, EPA, and peanuts.
  • the agent and the fat-soluble substance have good pharmacological synergistic effects, and have good synergistic effects on human health, especially in oral supplementation of phospholipids, unsaturated fatty acids and fat-soluble drugs.
  • the present invention also provides a hydrophilic lipid composition containing an emulsifier and a liquid fat through with water
  • the base liquid is mixed, shaken to prepare an emulsion for oral drinking, and is used for preparing medicines or special foods for preventing and treating cardiovascular and cerebrovascular diseases; and for preparing medicines or special foods for nourishing or protecting cranial nerves
  • drugs for preventing and treating neurodegenerative diseases in the preparation of drugs for reducing the risk of myocardial infarction, stroke or cardiovascular disease; in the preparation of improving myocardial ischemia and improving cerebral ischemia, protecting the heart and brain
  • application in the preparation of drugs or special foods for treating fatty liver application in preparation of drugs or special foods for weight loss; Use of fatigued drugs or special foods; application in the preparation of drugs or special foods that provide unsaturated fatty acids; or in the preparation of drugs or special foods that provide fat-soluble drugs
  • the hydrophilic lipid composition of the present invention can also be used in the preparation of meals, and the hydrophilic lipid combination of the present invention can be used in any meal which needs to be prepared or formulated with water.
  • the emulsion formulated with water and water replaces the application of water in the preparation of meals.
  • the prepared food not only supplements the essential fatty acids and liquid fat, but also the prepared meals.
  • Concentrated oily aromas help to increase appetite and, more importantly, the process of making meals, for the consumer, on the one hand, is a pleasure, especially by passing oil-based substances and water-based substances for a second or two.
  • the vibration process of the clock instantly turns into an emulsion, which greatly enhances the consumer's desire to drink or eat.
  • the self-producing diet process produces a psychological desire to contribute to the healthy and nutrient-based oil-based substance of the present invention.
  • Ingestion on the other hand, the process of formulating the hydrophilic lipid composition of the present invention with water is a process of cooking, brain-moving and using the eye, especially for oil-based substances and water-based substances.
  • the substance oscillates through a second or two Cheng, instantly becomes an emulsion, greatly increasing the consumer's desire to drink or eat.
  • the self-producing diet process produces a psychological desire to contribute to the healthy nutrition of the present invention; In addition, this process of vibration (vibration and shaking) releases stress. This process brings a pleasant mood and optimizes eating mood. This pleasant state helps the diet to be healthy, not only helpful.
  • the action of the oil-based substance of the healthy nutrition of the invention can further improve the consumption of the beverage or the homogenized meal, reduce the rate of discarded beverages, and reduce waste and pollution.
  • the hydrophilic lipid composition provided by the invention realizes the product blending mode of oil-water rapid blending, and has great significance.
  • the oil-based substance and the water-based substance are separately packaged separately, and the individual packages of the two are separately combined, and the two are rapidly mixed to form an emulsion by shaking and mixing.
  • This method allows oil-based substances to be independently stored with water-based substances, so that their respective stability is significantly improved, no need to add an emulsion stabilizer, avoiding degradation of unsaturated fatty acids, greatly improving product stability and ensuring Quality, maintain a good flavor and taste, and also extend the shelf life or shelf life, which is conducive to the quality assurance and circulation of goods.
  • hydrophilic lipid composition provided by the present invention can not only bring more healthy fat to consumers, such as medium chain triglycerides, omega-3 fatty acids, omega-6 fatty acids, phospholipids, Arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid, plant sterols and other health, nutrition, disease prevention and control substances, such as protecting the cardiovascular and cerebrovascular, improving intelligence, nutrition nerves; and making consumers more It is easy and convenient to obtain these substances which are very beneficial to health and disease prevention by means of beverages, homogenized meals and ordinary meals.
  • hydrophilic lipid composition provided by the invention is beneficial to improving people's existing eating habits, and even beneficial to improving human meal making habits and meal matching concepts.
  • Bioavailability refers to the degree of utilization and utilization rate of the preparation absorbed into the blood circulation.
  • the present invention contains an emulsifier, a fat-soluble substance, rapidly forms an emulsion in a water-based liquid, has excellent water-oil solubility, and is active as a fat-soluble substance.
  • Oral preparations have a significant promoting effect and significance in the extent and speed of absorption into the blood circulation, which is of great significance for the improvement of the bioavailability of fat-soluble substances.
  • the absorption process of the preparation into the gastrointestinal tract is divided into two stages, namely, dispersion and absorption of the gastrointestinal wall. First, it needs to be dispersed in the gastric juice or intestinal fluid, and then contacted and attached to the gastrointestinal wall for absorption and into the blood.
  • the fat-soluble substances are prepared in the form of a water-dispersible emulsion, and the dissolution and dispersion speed of the fat-soluble substances are remarkable. Accelerate, greatly increase the degree of dispersion and dispersion speed in gastric juice or intestinal juice, make the fat-soluble substance more fully contact with the gastrointestinal wall, and adhere to the gastrointestinal wall to absorb the active ingredients into the blood, which is more sufficient. The improvement of the bioavailability of soluble substances is of great significance.
  • a hydrophilic lipid composition provided by the present invention such as nervonic acid, DHA, EPA, phosphatidylserine, medium chain triglyceride, ⁇ -linolenic acid, ⁇ -linolenic acid, etc.
  • nervonic acid such as nervonic acid, DHA, EPA, phosphatidylserine, medium chain triglyceride, ⁇ -linolenic acid, ⁇ -linolenic acid, etc.
  • the hydrophilic lipid composition of the invention and the preparation method thereof solve many shortcomings of the prior art, and have the following advantages: 1. Oil-based components, no water, good stability; 2. Excellent hydrophilicity, energy It is mixed with water and dispersed to form an emulsion, which is convenient for consumption and easy to operate. 3. It is convenient and quick to mix.
  • a uniform emulsion can be formed in 1 to 5 seconds to prepare or make a diet. Bring a pleasant mood, help release stress and diet, optimize eating mood; 4, improve the bioavailability of functional fatty acids or fat-soluble substances; 5, the emulsion formed has better stability, static After being placed for more than 5 minutes, a uniform and stable emulsion can be maintained. 6. After the stratification is formed for a long time, the emulsion can be formed by a slight shaking, which is beneficial to the user intermittently. Drink or take it orally.
  • Example 1 A hydrophilic lipid composition, a preparation and formulation method thereof, and a combination use.
  • a hydrophilic lipid composition in a percentage by weight, containing:
  • the phospholipid is selected from the group consisting of soybean phospholipids, soy lecithin, egg yolk phospholipids, egg yolk lecithin or krill oil.
  • the preparation method thereof comprises:
  • the liquid prepared in (1) is placed in an emulsification tank, heated to a temperature of 45 ° C or higher, and stirred at a stirring speed of more than 500 r/min for 3 to 25 minutes, and then at 3 to 5 minutes.
  • the liquid is quickly cooled to below 25 ° C, the stirring is stopped, and the mixture is allowed to stand; or, the liquid prepared in (1) is placed in an emulsification tank, and the temperature of the liquid is 45 ° C or higher, and the pressure is performed in the homogenizer. Homogenization of 20 to 58 MPa, and then quickly cool the liquid to below 25 ° C within 3 to 5 minutes, and stop stirring;
  • the preparation method 2 thereof includes:
  • the oily liquid prepared in (2) is filled in a container, and the container is further filled with nitrogen gas, and the gas pressure in the container is stronger than 1.2 atm, sealed and sealed, packaged, and inspected.
  • the preparation method thereof includes:
  • emulsifier a mixture of the fat-soluble substance prepared in (2) in an amount of 3 to 7 times by weight of the emulsifier and the emulsifier, placed in an emulsification tank, continuously supplied with nitrogen into the oily liquid or kept emulsified
  • the pressure in the tank is stronger than 1.3 atmospheres, and is stirred under the stirring speed of more than 300r/min, so that the oily liquid exhibits a non-transparent nitrogen-rich foam-type grease, or the oil is foamed, and the stirring is stopped;
  • the oily liquid prepared in (4) is filled in a container, and the container is further filled with nitrogen gas and the gas pressure in the container is stronger than 1.2 atm, sealed and sealed, packaged, and inspected.
  • Rapid compounding performance Pour any proportion of the hydrophilic lipid composition and water-based liquid in the present embodiment into a mixing bottle, wherein the weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 10 :1, so that the total volume of the hydrophilic lipid composition and the water-based liquid does not exceed 98% of the capacity of the blending bottle, tighten the lid of the blending bottle, and shake the blending bottle at least once in 1 second by hand or robot.
  • the frequency of the bottle is shaken for up to 5 seconds. When the bottle is shaken, the distance of the bottle is not less than 10 cm per movement, and the mixture is moved to the remaining space of the bottle, preferably the mixture is dispensed.
  • the remaining space moves and impacts the cover of the bottle, and according to the above method, a uniform emulsion can be formed.
  • the emulsion is still in a uniform emulsion after standing at room temperature for 5 minutes, and no delamination occurs; , is a glass bottle with a lid, a plastic bottle with a lid, an aluminum-plastic paper box with a lid, a metal container with a lid, for example, a polymer PET bottle, a high-density polyethylene bottle, etc.; Capable of tightening the lid for vibrating and dispensing, preferably mixing the bottle
  • the volume of the bottle is not more than 3 liters.
  • the volume of the bottle is preferably 0.5 liter.
  • the aqueous base liquid includes water, a liquid having a water content of more than 60%, or an aqueous solution containing ethanol.
  • the water-based liquid is selected from the following one.
  • Aqueous solution of one or more substances sucrose, glucose, fructose, maltose, chitosan oligosaccharide, oligofructose, xylooligosaccharide, polydextrose, inulin, taurine, cysteine, cystine, glycine, Aspartic acid, asparagine, glutamic acid, glutamine, lysine, arginine, ornithine, vitamin C, vitamin B, L-carnitine, folic acid, niacin, choline, inositol.
  • Example 2 Hydrophilic lipid composition, preparation and formulation method thereof.
  • a hydrophilic lipid composition in a percentage by weight, containing:
  • the phospholipid is selected from the group consisting of soybean phospholipid, soybean lecithin, egg yolk phospholipid, egg yolk lecithin or krill oil;
  • the donor vegetable oil of ⁇ -linolenic acid is selected from the group consisting of linseed oil, perilla seed oil, pumpkin seed oil, and peony seed.
  • ⁇ -linolenic acid donor oil is selected from ⁇ -linolenic acid oil
  • linoleic acid donor vegetable oil is selected from soybean oil, corn oil, peanut oil, sunflower oil, olive oil , milk thistle seed oil, pumpkin seed oil, long handle almond oil, palm oil, sesame oil, walnut oil, rapeseed oil, safflower seed oil, grape seed oil, salicin seed oil, wheat germ oil, corn Germ oil, light-skinned avocado oil, salted wood fruit oil, peony seed oil, samara oil, glutinous rice oil, tomato seed oil, pepper seed oil, mustard seed oil, tea oil (including tea seed oil, Camellia seed oil or tea tree oil), rice bran oil, shea butter, borage oil, pepper seed oil, coconut oil or cottonseed oil; oleic acid donor vegetable oil is selected from the group consisting of soybean oil, corn oil, peanut oil, sunflower oil, Olive oil, pumpkin seed oil,
  • the preparation method is the same as the preparation method 1, the preparation method 2 or the preparation method 3 in the first embodiment, and the preparation method in the embodiment 1 can be completely applied to the embodiment.
  • any one of the proportions of the hydrophilic lipid composition is formulated into an emulsion by shaking with a water-based liquid, preferably the aqueous liquid is selected from the aqueous solution of one or more of the following: sucrose, Glucose, fructose, maltose, chitosan oligosaccharide, oligofructose, xylooligosaccharide, polydextrose, inulin, taurine, cysteine, cystine, glycine, aspartic acid, asparagine, valley Acid, glutamine, lysine, arginine, ornithine, vitamin C, vitamin B, L-carnitine, folic acid, niacin, choline, inositol, or water-based liquid selected from animal lotions, animals An aqueous emulsion of protein powder or an aqueous emulsion of vegetable protein powder.
  • Example 3 a hydrophilic lipid composition, a preparation thereof, and a formulation method.
  • a hydrophilic lipid composition in a percentage by weight, containing:
  • the phospholipid comprises soybean phospholipid, soybean lecithin, egg yolk phospholipid, egg yolk lecithin or krill oil
  • the donor vegetable oil of linoleic acid is selected from the group consisting of soybean oil, corn oil, peanut oil, sunflower oil, olive oil, water fly Quail seed oil, pumpkin seed oil, long handle almond oil, palm oil, sesame oil, walnut kernel oil, rapeseed oil, safflower seed oil, grape seed oil, salicin seed oil, wheat germ oil, corn germ oil, Light-skinned avocado oil, salted wood fruit oil, peony seed oil, samara oil, glutinous rice oil, tomato seed oil, pepper seed oil, mustard seed oil, tea oil (including tea seed oil, camellia seed oil) Or tea tree oil), rice bran oil, chili seed oil, pomegranate seed oil, Brucea javanica oil or coconut oil
  • oleic acid donor vegetable oil is selected from the group consisting of soybean oil, corn oil, peanut oil, sunflower oil, olive
  • the preparation method is the same as the preparation method 1, the preparation method 2 or the preparation method 3 in the first embodiment, and the preparation method in the embodiment 1 can be completely applied to the embodiment.
  • any one of the proportions of the hydrophilic lipid composition is formulated into an emulsion by shaking with a water-based liquid.
  • the water-based liquid is selected from an aqueous solution of one or more of the following: sucrose, glucose , fructose, maltose, chitosan oligosaccharide, oligofructose, xylooligosaccharide, polydextrose, inulin, taurine, cysteine, cystine, glycine, aspartic acid, asparagine, glutamine Acid, glutamine, lysine, arginine, ornithine, vitamin C, vitamin B, L-carnitine, folic acid, niacin, choline, inositol, or water-based liquid selected from animal lotion, animal protein An aqueous emulsion of powdered water or vegetable protein powder.
  • Example 4 a hydrophilic lipid composition, a preparation thereof, and a formulation method.
  • a hydrophilic lipid composition in a percentage by weight, containing:
  • the phospholipid is selected from the group consisting of soybean phospholipid, soybean lecithin, egg yolk phospholipid, egg yolk lecithin or krill oil;
  • the donor vegetable oil of ⁇ -linolenic acid comprises linseed oil, perilla seed oil, pumpkin seed oil, peony seed oil , Eucommia seed oil or Meito fruit oil;
  • ⁇ -linolenic acid donor oil is selected from ⁇ -linolenic acid oil;
  • linoleic acid donor vegetable oil is selected from soybean oil, corn oil, peanut oil, sunflower oil, olive oil, Milk thistle seed oil, pumpkin seed oil, long handle almond oil, palm oil, sesame oil, walnut oil, rapeseed oil, safflower seed oil, grape seed oil, salicin seed oil, wheat germ oil, corn germ Oil, light-skinned avocado oil, salted wood fruit oil, peony seed oil, samara oil, glutinous rice oil, tomato seed oil, pepper seed oil,
  • the preparation method is the same as the preparation method 1, the preparation method 2 or the preparation method 3 in the first embodiment, and the preparation method in the embodiment 1 can be completely applied to the embodiment.
  • any one of the proportions of the hydrophilic lipid composition is formulated into an emulsion by shaking with a water-based liquid.
  • the water-based liquid is selected from an aqueous solution of one or more of the following: sucrose, glucose , fructose, maltose, chitosan oligosaccharide, oligofructose, xylooligosaccharide, polydextrose, inulin, taurine, cysteine, cystine, glycine, aspartic acid, asparagine, glutamine Acid, glutamine, lysine, arginine, ornithine, vitamin C, vitamin B, L-carnitine, folic acid, niacin, choline, inositol, or water-based liquid selected from animal lotion, animal protein An aqueous emulsion of powdered water or vegetable protein powder.
  • the hydrophilic lipid composition of any one of Examples 2 to 4 was obtained, and had a good rapid formulation property. Rapid formulation performance: Pour any proportion of the hydrophilic lipid composition of the embodiment with a water-based liquid into the mixing bottle, wherein the weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 3: 1. Preferably, the weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 10:1, so that the total volume of the hydrophilic lipid composition and the water-based liquid does not exceed 50% of the capacity of the blending bottle, and the mixing bottle is tightened. Cover, use the hand or robot to shake the bottle at least once in 1 second, so that the bottle shakes for up to 5 seconds.
  • the distance of the bottle is not less than 10 cm.
  • moving the mixture to the remaining space of the blending bottle preferably moving the mixture to the remaining space of the blending bottle and impacting the cap of the blending bottle, as described above, to form a uniform emulsion, the emulsion at room temperature After standing for 5 minutes, it still shows a uniform emulsion without delamination;
  • the matching bottle is a glass bottle with a lid, a plastic bottle with a lid, an aluminum-plastic paper box with a lid, a metal container with a lid, for example , polymer PET bottles, high density polyethylene bottles, etc.; with cover is
  • the volume of the blending bottle is not more than 3 liters, for example, preferably the volume of the blending bottle is 0.5 liter
  • the aqueous-based liquid comprises water, a liquid having a water content of more than 60%, or contains ethanol.
  • Aqueous solutions for example, but not limited to, animal emulsions, fruit juices, fruit and vegetable beverages, plant extracts or beverages, carbohydrate solutions or beverages, vegetable protein beverages, aqueous emulsions of animal milk powder, aqueous solutions of amino acids, and the like.
  • Packing combination a packaging composition comprising independently packaging a hydrophilic lipid composition of any one of the embodiments and presenting in the same package or the same package simultaneously with the dispensing bottle,
  • the dispensing bottle is an empty bottle with a lid; or the conditioning bottle is pre-loaded with a volume of water-based liquid for directly adding the fatty acid composition to the mixing bottle to form a uniform emulsion by shaking; or
  • the independent packaging and the blending bottle of the hydrophilic lipid composition are simultaneously present in one package or the packaging bag, or may be formed by sticking and fixing, and the label is fixed, or may be
  • the packaging bottle or the packaging bag containing the hydrophilic lipid composition is fixed together with the dispensing bottle in the form of a packaging kit, or the packaging composition contains the hydrophilic lipid of any one of the ratios in the embodiment.
  • the composition, and the labeling body thereof has a content obtained by shaking a hydrophilic lipid composition and a water-based liquid to obtain an emulsion.
  • the sum of the volume of the water-based liquid and the hydrophilic lipid composition is not more than 98% of the capacity of the container containing the water-based liquid or the capacity of the blended bottle.
  • the hydrophilic lipid composition of any one of the examples is separately sealed in the chamber of the lid member of the container, the water-based liquid is sealed in the container, and the lid member of the container is mounted on the container The container is sealed at the opening so that the lipid composition and the water-based liquid are each independently sealed.
  • the lid member of the container is opened to release the lipid composition in the lid member, and the water-based liquid in the container Mixing, further, forming a uniform emulsion by shaking;
  • the lipid composition in the chamber of the lid member of the container is injected into the water-based liquid in the form of a liquid column having a diameter of 0.4 mm to 2 mm, for example, by a high-pressure gas in a chamber of the lid member of the container.
  • the composition is sprayed out, or the lipid composition is sprayed by means of piston pressurization or bolus injection, and the lipid composition is mixed with a water-based liquid and shaken to form an emulsion, the water-based liquid including water, A liquid having a water content of more than 60% or an aqueous solution containing ethanol.
  • the sum of the volume of the water-based liquid and the hydrophilic lipid composition is not more than 98% of the capacity of the container containing the water-based liquid.
  • Example 6 the hydrophilic lipid composition of any one of Examples 1 to 4, 1 g of the hydrophilic lipid composition was added, and 2 to 150 ml of the water-based liquid was added, and the mixture was shaken, 5 In the second, even within 1 second, the emulsion can be formed, and the formed emulsion can be kept stable at room temperature for more than 5 minutes, and can be kept stable, and can be kept uniform and stable without delamination;
  • the hydrophilic lipid composition and the water-based liquid are poured into a mixing bottle, wherein the weight ratio of the water-based liquid having a water content of more than 60% to the hydrophilic lipid composition is greater than 3:1, preferably The weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 10:1, so that the total volume of the hydrophilic lipid composition and the water-based liquid does not exceed 70% of the capacity of the blending bottle, and the lid of the blending bottle is tightened.
  • the distance of the mixing bottle is not less than 10 cm each time, and
  • the mixed liquid moves to the remaining space of the mixing bottle, preferably, the mixed liquid is moved to the remaining space of the mixing bottle and impacts the cover of the mixing bottle, and a uniform emulsion is formed according to the above method, and the emulsion is allowed to stand at room temperature.
  • the emulsion is still uniform in 5 minutes, and no stratification occurs;
  • the mixing bottle can be a glass bottle with a lid, a plastic bottle with a lid, an aluminum-plastic paper box with a lid, and a metal container with a lid.
  • hydrophilic lipid composition containing the emulsifier and the liquid fat of any of the examples 7 and 4 to 4 is prepared by mixing with a water-based liquid and further shaking to form an emulsion.

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Abstract

A packaging composition comprising a hydrophilic lipid composition and a water-based liquid that respectively are packaged individually and combined together. The hydrophilic lipid composition contains liquid fat and an emulsifier. The content of the liquid fat in the hydrophilic lipid composition in terms of weight is greater than 45%. The content of the emulsifier in the hydrophilic lipid composition in terms of weight is 0.05% to 8%. The weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 3:1. The sum of the volume of the water-based liquid and the hydrophilic lipid composition is no greater than 98% of the volume of a container holding the water-based liquid. A method for blending the hydrophilic liquid composition and the water-based liquid into an emulsion, comprising: pouring the hydrophilic lipid composition and the water-based liquid into a blending bottle, and shaking the blending bottle for at least once in one second either by hand or by a manipulator. Applications of the method for blending the hydrophilic lipid composition and the water-based liquid into the emulsion in preparing or blending a medicament, a special medical use formula food product, a healthcare food product, a nutritious food product or a cosmetic product.

Description

亲水性脂类组合物的包装组合物，其制备及调配方法和应用Packaging composition of hydrophilic lipid composition, preparation and formulation method and application thereof
技术领域 本发明涉及一种健康品组合物，具体是亲水性脂类组合物的包装组合物，及其制备方法、它的调配使用和应用。TECHNICAL FIELD The present invention relates to a health product composition, in particular to a packaging composition of a hydrophilic lipid composition, a process for the preparation thereof, its use and application.
本发明所述的健康品组合物，包括药物、特殊医学用途配方食品、保健食品、营养食品、化妆品等，具体是含有乳化剂、不含水的液体脂肪类的组合物。The health product composition according to the present invention includes a medicine, a special medical use formula food, a health food, a nutraceutical food, a cosmetic, etc., and specifically a composition containing an emulsifier and a liquid fat which does not contain water.
背景技术 一方面，众所周知的，包括不饱和脂肪酸在内的脂类物质与水是完全不相容的，然而在健康品的使用中，往往需要把具有健康营养作用的脂类物质与水溶性的健康营养物质同时使用，现有技术是将脂类物质与水基液体制备为乳浊液供给患者或特殊人群使用，然而这种预先制备的乳浊液，为了保持乳浊液的稳定性、延长市售保存期，添加有大量甚至超量的乳化剂，同时为了保持不饱和脂肪酸的稳定性，还加有大量的抗氧剂、防腐剂，并且采用碱性化合物，如氢氧化钠调节乳浊液的pH值，这些均不利于脂肪酸的口服吸收，甚至会带来健康危险；再者，不饱和脂肪酸及酯，如亚麻酸、亚油酸、油酸、花生四烯酸、共轭亚油酸、共轭亚油酸甘油酯、DHA、EPA、神经酸等在含水的混合液中，很容易氧化、降解，尤其在40℃以上的温度，会加速降解，造成不饱和脂肪酸的大量损失，并严重影响组合物的质量安全。BACKGROUND OF THE INVENTION On the one hand, it is well known that lipids including unsaturated fatty acids are completely incompatible with water. However, in the use of health products, it is often necessary to use a nutrient-rich lipid substance and water-soluble. The use of healthy nutrients is used at the same time. The prior art is to prepare a lipid substance and a water-based liquid for use as an emulsion for a patient or a special population. However, this pre-prepared emulsion maintains the stability and elongation of the emulsion. In the commercial shelf life, a large amount or even an excess of emulsifier is added, and in order to maintain the stability of unsaturated fatty acids, a large amount of antioxidants, preservatives, and alkaline compounds such as sodium hydroxide are used to adjust the opacity. The pH of the liquid, which is not conducive to the oral absorption of fatty acids, and even poses a health hazard; in addition, unsaturated fatty acids and esters, such as linolenic acid, linoleic acid, oleic acid, arachidonic acid, conjugated linoleum Acid, conjugated linoleic acid glyceride, DHA, EPA, nervonic acid, etc. in the aqueous mixture, it is easy to oxidize and degrade, especially at temperatures above 40 °C, accelerate degradation, build Loss of a large number of unsaturated fatty acids, and seriously affect the quality and safety of the composition.
另一方面，脂类物质，尤其是不饱和脂肪酸，在直接饮用时是非常油腻的并且难以接受；因此现有技术通过将不饱和脂肪酸制成软胶囊进行口服摄入，这很不利于口服摄入的便捷性，也不利于较大剂量的口服摄入，而且也不利于口服吸收。On the other hand, lipids, especially unsaturated fatty acids, are very greasy and unacceptable when consumed directly; therefore, the prior art takes oral intake by making unsaturated fatty acids into soft capsules, which is not conducive to oral taking. The convenience of access is also not conducive to large doses of oral intake, but also is not conducive to oral absorption.
中国专利公布号CN104397702A、CN104490773A、CN104397706A公开了含有磷脂、其它脂溶性物质和水的乳液组合物，其通过高速搅拌乳化、均质的加工过程，使脂溶性物质与水形成均一的乳化液，有利于食用和吸收。然而不利的是，一方面，不饱和脂肪酸的脂溶性物质在含水的混合液中，很容易氧化、降解，尤其在40℃以上的温度，会加速降解，造成不饱和脂肪酸的大量损失，并严重影响组合物的质量安全。Chinese Patent Publication Nos. CN104397702A, CN104490773A, and CN104397706A disclose an emulsion composition containing a phospholipid, another fat-soluble substance, and water, which forms a uniform emulsion of a fat-soluble substance and water by a high-speed stirring emulsification and a homogeneous processing process. Conducive to consumption and absorption. However, on the one hand, the fat-soluble substance of unsaturated fatty acid is easily oxidized and degraded in an aqueous mixed solution, especially at a temperature above 40 ° C, which accelerates degradation, resulting in a large loss of unsaturated fatty acids, and is severe. Affect the quality and safety of the composition.
通常，不含水的脂类组合物，其稳定性良好，但是不含水的脂类组合物，其油性强，与水完全不相溶并漂浮在水面上，搅拌或摇晃不能使脂类组合物与水混合均匀，这对于脂类组合物的调配使用极为不利，在医药产品或健康食品等使用中，其使用范围严重受限，尤其对于需要将脂类组合物与水剂混合均匀，或者需要将脂类组合物调配成营养食品/特殊医学用途配方食品中可以口服的匀浆膳，是十分困难的；并且，还要满足使用者快速、容易地进行与水剂的调配，调配好的混合液呈乳浊液，并且不易发生肉眼可见的分层，有利于食用和使用。 Generally, a non-aqueous lipid composition having good stability, but a non-aqueous lipid composition is oily, completely incompatible with water and floating on the water surface, and stirring or shaking does not allow the lipid composition to The water is evenly mixed, which is extremely disadvantageous for the preparation of the lipid composition. In the use of pharmaceutical products or health foods, the scope of use thereof is severely limited, especially for the need to mix the lipid composition with the water agent uniformly, or need to It is very difficult to formulate a lipid composition into a nutrient food/special medical use formula which can be orally administered as a homogenized meal; and it is also necessary to satisfy the user's quick and easy formulation with a liquid agent, and to prepare a good mixture. It is an emulsion and is not easily visible to the naked eye, which is beneficial for consumption and use.
在实际应用中，不含水的液体脂肪，在与水基液体配制成易于口服摄入的产品状态时，尤其在配制营养食品、特殊医学用途配方食品、药品等实际应用或临床使用中，应当满足以下四个条件：In practical applications, liquid fats that do not contain water should be satisfied when they are formulated into a product that is easy to be orally ingested with water-based liquids, especially in the practical application or clinical use of nutritional foods, special medical formulas, medicines, etc. The following four conditions:
1、具有亲水性，能与水基液体混合并分散形成乳浊液，以改善其难以接受的油腻性口感；1. It is hydrophilic, can be mixed with water-based liquid and dispersed to form an emulsion to improve its unacceptably greasy mouthfeel;
2、与水基液体在容器中搅拌或摇晃，可在很短的时间内形成均一的乳浊液，例如在10秒内形成均一的乳浊液，以保证配制时的快速和便捷性；2. Stir or shake with water-based liquid in a container to form a uniform emulsion in a short period of time, for example, to form a uniform emulsion within 10 seconds to ensure rapid and convenient formulation;
3、与水基液体所形成的乳浊液有较好的稳定性，不易于发生明显的分层，例如在至少在1分钟内不发生可见的分层，以利于使用者具有较长的饮用或口服摄入的时间；3. The emulsion formed by the water-based liquid has good stability and is not prone to obvious delamination, for example, no visible delamination occurs in at least 1 minute, so that the user has a longer drinking period. Or the time of oral intake;
4、所形成的乳浊液在静置发生分层后，经轻微摇晃，仍可形成均一的乳浊液，以利于使用者间断性地饮用或口服摄入。4. The formed emulsion can form a uniform emulsion after slight swaying after standing to facilitate intermittent drinking or oral ingestion by the user.
显然，对于不含水的脂类组合物，现有技术无法满足上述这四个条件，通常是将不含水的脂类组合物做成软胶囊的制剂来使用，这极大限制了消费者或患者的摄入需求，例如，对于不能进行吞咽而需要肠内营养支持的患者，这种软胶囊制剂是无法对其管饲摄入的，也限制了脂溶性物质的口服吸收和利用。Obviously, for the non-aqueous lipid composition, the prior art cannot satisfy the above four conditions, and generally the use of the non-aqueous lipid composition into a soft capsule preparation is used, which greatly limits the consumer or the patient. The demand for intake, for example, for patients who cannot be swallowed and need enteral nutrition support, this soft capsule preparation cannot be ingested by the tube, and also limits the oral absorption and utilization of the fat-soluble substance.
发明内容 本发明的目的是提供一种具有优异的亲水性，以及在水基液体中快速溶散而形成乳浊液的脂类组合物及其调配方法。这种脂类组合物具有优异的亲水性，既保证了脂类组合物在生产、储藏运输、货架期的产品质量，又利于在使用时与水基液体进行调配、溶解，能够方便、快捷地使用。Disclosure of the Invention An object of the present invention is to provide a lipid composition which has excellent hydrophilicity and which is rapidly dissolved in a water-based liquid to form an emulsion, and a method of blending the same. The lipid composition has excellent hydrophilicity, which not only ensures the product quality of the lipid composition in production, storage and transportation, and shelf life, but also facilitates mixing and dissolving with the water-based liquid during use, and is convenient and quick. Use.
本发明提供了含有液体脂肪和乳化剂的亲水性脂类组合物，所述脂类组合物与水基液体混合后，通过振晃，可形成乳浊液。进一步，本发明还提供了其包装组合物、制备方法、它的调配使用和应用。The present invention provides a hydrophilic lipid composition containing a liquid fat and an emulsifier, which is mixed with a water-based liquid and then shaken to form an emulsion. Further, the present invention also provides a packaging composition thereof, a preparation method, its formulation use and application.
本发明所述的液体脂肪，定义为在常温常压下呈现液态的脂肪酸或油脂，包括饱和或不饱和的脂肪酸、饱和或不饱和的油脂、饱和或不饱和的脂肪酸的甘油三酯、饱和或不饱和的脂肪酸的甘油二酯，例如包括但不限于油酸、亚油酸、亚麻酸、中链甘油三酯、甘油二酯、中长链脂肪酸，等等。The liquid fat of the present invention is defined as a fatty acid or fat which exhibits a liquid state at normal temperature and pressure, and includes a saturated or unsaturated fatty acid, a saturated or unsaturated fat, a triglyceride of a saturated or unsaturated fatty acid, a saturated or The diglyceride of the unsaturated fatty acid, for example, but not limited to, oleic acid, linoleic acid, linolenic acid, medium chain triglyceride, diglyceride, medium long chain fatty acid, and the like.
本发明提供含有乳化剂、脂溶性物质A和脂溶性物质B的亲水性脂类组合物，所述乳化剂选自下述一种或多种物质：磷脂、蔗糖脂肪酸酯、单，双甘油脂肪酸酯、聚甘油脂肪酸酯、丙二醇脂肪酸酯、乳酸脂肪酸甘油酯、吐温20、吐温40、吐温60、吐温80、司盘20、司盘40、司盘60、司盘65、司盘80，其中乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.1％～6％；所述脂溶性物质A选自下述一种或多种物质：油酸、亚油酸、亚麻酸、中链甘油三酯、甘油二酯、中长链脂肪酸，其中脂溶性物质A的含 量以重量比计大于45％；所述脂溶性物质B选自下述一种或多种物质：神经酸(顺-15-二十四碳烯酸)、DHA(二十二碳六烯酸)、EPA(二十碳五烯酸)、花生四烯酸、维生素E、维生素A、维生素D、共轭亚油酸、共轭亚油酸甘油酯、磷脂酰丝氨酸、植物甾醇、植物甾醇酯、植物甾烷醇酯、米糠脂肪烷醇、多烯磷脂酰胆碱，其中脂溶性物质B的含量以重量比计为0～30％，优选所述脂溶性物质B的含量以重量比计为0.01％～30％；所述脂溶性物质B的含量以重量比计为0～30％，表示不含脂溶性物质B至最高含30％的脂溶性物质B；所述亚麻酸包括α-亚麻酸或γ-亚麻酸，所述中长链脂肪酸包括中链脂肪酸或长链脂肪酸。The present invention provides a hydrophilic lipid composition containing an emulsifier, a fat-soluble substance A and a fat-soluble substance B, the emulsifier being selected from one or more of the following: phospholipids, sucrose fatty acid esters, single and double Glycerol fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty acid glyceride, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Division The disc 65, the disc 80, wherein the content of the emulsifier is 0.05% to 8% by weight, preferably the content of the emulsifier is 0.1% to 6% by weight; the fat-soluble substance A is selected from the following one Or a variety of substances: oleic acid, linoleic acid, linolenic acid, medium chain triglycerides, diglycerides, medium and long chain fatty acids, wherein the fat soluble substance A The amount is greater than 45% by weight; the fat-soluble substance B is selected from one or more of the following: nervonic acid (cis-15-tetracosenoic acid), DHA (docosahexaenoic acid) ), EPA (eicosapentaenoic acid), arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester a plant stanol ester, a rice bran fatty alcohol, a polyene phosphatidylcholine, wherein the content of the fat-soluble substance B is 0 to 30% by weight, preferably the content of the fat-soluble substance B is by weight. 0.01% to 30%; the content of the fat-soluble substance B is 0 to 30% by weight, which means that the fat-soluble substance B is not contained up to 30% of the fat-soluble substance B; the linolenic acid includes α-linen Acid or gamma-linolenic acid, the medium long chain fatty acid comprising a medium chain fatty acid or a long chain fatty acid.
本发明所述脂溶性物质A和脂溶性物质B都是脂肪酸类或脂溶性物质，通常是从植物油或动物油中提取的，或者是从植物油或动物油(如鱼油、磷虾油)中提取后进一步再合成的化合物或油脂，例如，卵磷脂是从大豆油或蛋黄中提取的，磷脂酰丝氨酸是以卵磷脂和L-丝氨酸为原料，采用磷脂酶转化反应后，纯化后制得；再例如，植物甾醇包括从大豆油、菜籽油、玉米油、葵花籽油、塔罗油中提取的β-谷甾醇、菜油甾醇、豆甾醇等；The fat-soluble substance A and the fat-soluble substance B of the present invention are both fatty acids or fat-soluble substances, usually extracted from vegetable oil or animal oil, or further extracted from vegetable oil or animal oil (such as fish oil, krill oil). a resynthesized compound or fat, for example, lecithin is extracted from soybean oil or egg yolk, and phosphatidylserine is produced by using lecithin and L-serine as a raw material, and is purified by a phospholipase conversion reaction; for example, Phytosterols include β-sitosterol, campesterol, stigmasterol, etc. extracted from soybean oil, rapeseed oil, corn oil, sunflower oil, and tallow oil;
另一方面，本发明所述脂溶性物质A或脂溶性物质B，通常会以一定含量的比例存在于油脂中，本发明所述脂溶性物质A或脂溶性物质B，也可以以含有所述脂溶性物质A或脂溶性物质B的植物油或动物油，或者是从植物油或动物油中提取后进一步再合成或发酵的化合物或油脂应用于本发明。例如，α-亚麻酸含量大于30％的紫苏籽油、亚麻籽油、牡丹籽油、美藤果油或杜仲籽油作为α-亚麻酸的供体，应用于本发明；γ-亚麻酸含量大于8％的γ-亚麻酸油脂作为γ-亚麻酸的供体，应用于本发明；On the other hand, the fat-soluble substance A or the fat-soluble substance B of the present invention is usually present in the oil and fat in a certain amount, and the fat-soluble substance A or the fat-soluble substance B of the present invention may also contain the above-mentioned A vegetable oil or animal oil of the fat-soluble substance A or the fat-soluble substance B, or a compound or fat which is further synthesized or fermented after being extracted from vegetable oil or animal oil is used in the present invention. For example, perilla seed oil, linseed oil, peony seed oil, cane fruit oil or eucommia seed oil having an α-linolenic acid content of more than 30% is used as a donor of α-linolenic acid, and is applied to the present invention; γ-linolenic acid Γ-linolenic acid oil having a content of more than 8% is used as a donor of γ-linolenic acid, and is applied to the present invention;
例如，油酸或亚油酸含量大于40％的大豆油、玉米油、花生油、葵花籽油、橄榄油、水飞蓟籽油、长柄扁桃油、棕榈油、芝麻油、核桃仁油、菜籽油、红花籽油、葡萄籽油、米糠油、辣椒籽油、花椒籽油、芥菜籽油、椰子油、棉籽油、小麦胚芽油、杜仲籽油、番茄籽油、水飞蓟籽油、南瓜籽油、磷虾油、茶属油，包括茶叶籽油、油茶籽油或茶树油，长柄扁桃油、光皮梾木果油、盐地碱蓬籽油、美藤果油、盐肤木果油、牡丹籽油、翅果油、御米油、石榴籽油、鸦胆子油、月见草油、黑加仑油、乳木果油、玻璃苣油、木姜子油、松籽油、大麻籽油、胡桃油、芥花油或生姜油作为油酸或亚油酸的供体，应用于本发明；For example, soybean oil, corn oil, peanut oil, sunflower oil, olive oil, milk thistle seed oil, long handle almond oil, palm oil, sesame oil, walnut oil, rapeseed with oleic acid or linoleic acid content greater than 40% Oil, safflower seed oil, grape seed oil, rice bran oil, pepper seed oil, pepper seed oil, mustard seed oil, coconut oil, cottonseed oil, wheat germ oil, Eucommia seed oil, tomato seed oil, milk thistle seed oil , pumpkin seed oil, krill oil, tea oil, including tea seed oil, camellia seed oil or tea tree oil, long handle almond oil, light skin beech oil, salt soda seed oil, cane fruit oil, salt Skin oil, peony seed oil, samara oil, glutinous rice oil, pomegranate seed oil, brucea oil, evening primrose oil, blackcurrant oil, shea butter, borage oil, wood ginger oil, pine nuts Oil, hemp seed oil, walnut oil, canola oil or ginger oil as a donor of oleic acid or linoleic acid, used in the present invention;
例如，中长链脂肪酸食用油中含有大于11％的中链脂肪酸、大于10％的长链脂肪酸，中长链脂肪酸食用油可作为中长链脂肪酸、中链脂肪酸或长链脂肪酸的供体，应用于本发明；For example, medium-long-chain fatty acid edible oil contains more than 11% of medium-chain fatty acids and more than 10% of long-chain fatty acids, and medium-long-chain fatty acid edible oil can be used as a medium-long-chain fatty acid, medium-chain fatty acid or long-chain fatty acid. Applied to the present invention;
例如，神经酸含量在3％～8％的元宝枫籽油或鲨鱼油作为神经酸的供体，应用于本发明；For example, ingot ore oil having a lingonic acid content of 3% to 8% or a shark oil as a donor of nervonic acid is used in the present invention;
例如，DHA含量在3％～6％的DHA藻油作为DHA的供体，应用于本发明，DHA含量在3％～15％的鱼油或鱼油提取物作为DHA的供体，应用于本发明，DHA含量大于3％的磷虾油作为DHA的供体，应用于本发明；For example, DHA algal oil having a DHA content of 3% to 6% is used as a donor of DHA, and is applied to the present invention, and a fish oil or fish oil extract having a DHA content of 3% to 15% is used as a donor of DHA, and is applied to the present invention. Krill oil having a DHA content of more than 3% is used as a donor of DHA, and is applied to the present invention;
例如，总磷脂含量大于35％的大豆磷脂、磷虾油、大豆卵磷脂、蛋黄磷脂、蛋黄卵磷脂 作为磷脂的供体，应用于本发明。For example, soybean phospholipids, krill oil, soy lecithin, egg yolk phospholipids, egg yolk lecithin with a total phospholipid content greater than 35% As a donor of phospholipids, it is used in the present invention.
进一步的，本发明提供含有乳化剂、脂溶性物质A和脂溶性物质B的亲水性脂类组合物，所述乳化剂选自下述一种或多种物质：磷脂、蔗糖脂肪酸酯、单，双甘油脂肪酸酯、聚甘油脂肪酸酯、丙二醇脂肪酸酯、乳酸脂肪酸甘油酯、吐温20、吐温40、吐温60、吐温80、司盘20、司盘40、司盘60、司盘65、司盘80；其中乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.1％～6％；所述脂溶性物质A选自中链甘油三酯和下述一种或多种物质：油酸、亚油酸、α-亚麻酸、γ-亚麻酸、甘油二酯、中长链脂肪酸，其中中链甘油三酯在亲水性脂类组合物中的含量以重量比计为30％～99％，优选中链甘油三酯的含量以重量比计为40％～99％，优选中链甘油三酯的含量以重量比计为45％～98％；所述脂溶性物质B选自下述一种或多种物质：神经酸、DHA、EPA、花生四烯酸、维生素E、维生素A、维生素D、共轭亚油酸、共轭亚油酸甘油酯、磷脂酰丝氨酸、植物甾醇、植物甾醇酯、植物甾烷醇酯、米糠脂肪烷醇、多烯磷脂酰胆碱，其中脂溶性物质B的含量以重量比计为0～30％，优选脂溶性物质B的含量以重量比计为0.01％～30％；所述中长链脂肪酸包括中链脂肪酸或长链脂肪酸，所述乳化剂还包括其各种型号、规格、聚合度、酯化度、单/双酯，或其包含的单体成分，所述磷脂包括卵磷脂、磷脂酰乙醇胺、磷脂酰肌醇或磷脂酰甘油；Further, the present invention provides a hydrophilic lipid composition containing an emulsifier, a fat-soluble substance A, and a fat-soluble substance B, the emulsifier being selected from one or more of the following: a phospholipid, a sucrose fatty acid ester, Mono, diglycerin fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty acid glyceride, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80; wherein the content of the emulsifier is 0.05% to 8% by weight, preferably the content of the emulsifier is 0.1% to 6% by weight; the fat-soluble substance A is selected from the group consisting of Medium chain triglyceride and one or more of the following: oleic acid, linoleic acid, alpha-linolenic acid, gamma-linolenic acid, diglyceride, medium long chain fatty acid, wherein medium chain triglyceride is hydrophilic The content of the lipid composition is 30% to 99% by weight, preferably the content of the medium chain triglyceride is 40% to 99% by weight, preferably the content of the medium chain triglyceride is by weight. 45% to 98%; the fat-soluble substance B is selected from one or more of the following substances: nervonic acid, DHA, EPA, peanut Tetraenoic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, The phosphatidylcholine wherein the content of the fat-soluble substance B is 0 to 30% by weight, preferably the content of the fat-soluble substance B is 0.01% to 30% by weight; the medium-long chain fatty acid includes a medium chain Fatty acid or long-chain fatty acid, the emulsifier also includes various types, specifications, degree of polymerization, degree of esterification, mono/diester, or monomer components thereof, including lecithin, phosphatidylethanolamine, Phosphatidylinositol or phosphatidylglycerol;
所述脂溶性物质B的含量以重量比计为0.01％～30％，优选脂溶性物质B的含量以重量比计为0.05％～25％，优选脂溶性物质B的含量以重量比计为0.01％、0.02％、0.03％、0.04％、0.05％、0.06％、0.07％、0.08％、0.09％、0.1％、0.2％、0.3％、0.4％、0.5％、0.6％、0.7％、0.8％、0.9％、1％、1.1％、1.2％、1.3％、1.4％、1.5％、1.5％、1.6％、1.7％、1.8％、1.9％、2％、2.1％、2.2％、2.3％、2.4％、2.5％、2.6％、2.7％、2.8％、2.9％、3％、3.1％、3.2％、3.3％、3.4％、3.5％、3.6％、3.7％、3.8％、3.9％、4％、4.1％、4.2％、4.3％、4.4％、4.5％、4.6％、4.7％、4.8％、4.9％、5％、5.1％、5.2％、5.3％、5.4％、5.5％、5.6％、5.7％、5.8％、5.9％、6％、6.1％、6.2％、6.3％、6.4％、6.5％、6.6％、6.7％、6.8％、6.9％、7％、7.1％、7.2％、7.3％、7.4％、7.5％、7.6％、7.7％、7.8％、7.9％、8％、8.1％、8.2％、8.3％、8.4％、8.5％、8.6％、8.7％、8.8％、8.9％、9％、9.1％、9.2％、9.3％、9.4％、9.5％、9.6％、9.7％、9.8％、9.9％、10％、11％、12％、13％、14％、15％、16％、17％、18％、19％、20％、21％、22％、23％、24％、25％、26％、27％、28％、29％、30％。The content of the fat-soluble substance B is 0.01% to 30% by weight, preferably the content of the fat-soluble substance B is 0.05% to 25% by weight, and preferably the content of the fat-soluble substance B is 0.01 by weight. %, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4% 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1 %, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5%, 5.1%, 5.2%, 5.3%, 5.4%, 5.5%, 5.6%, 5.7%, 5.8%, 5.9%, 6%, 6.1%, 6.2%, 6.3%, 6.4%, 6.5%, 6.6%, 6.7%, 6.8%, 6.9%, 7%, 7.1%, 7.2%, 7.3%, 7.4% , 7.5%, 7.6%, 7.7%, 7.8%, 7.9%, 8%, 8.1%, 8.2 8.3%, 8.4%, 8.5%, 8.6%, 8.7%, 8.8%, 8.9%, 9%, 9.1%, 9.2%, 9.3%, 9.4%, 9.5%, 9.6%, 9.7%, 9.8%, 9.9 %, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%.
进一步的，本发明提供含有乳化剂、脂溶性物质A和脂溶性物质B的亲水性脂类组合物，所述乳化剂选自下述一种或多种物质：磷脂、蔗糖脂肪酸酯、单，双甘油脂肪酸酯、聚甘油脂肪酸酯、丙二醇脂肪酸酯、乳酸脂肪酸甘油酯、吐温20、吐温40、吐温60、吐温80、司盘20、司盘40、司盘60、司盘65、司盘80，其中乳化剂的含量以重量比计为0.05％～8％；所述脂溶性物质A选自亚麻酸和下述一种或多种物质：油酸、亚油酸、中链甘油三酯、甘油二酯、中长链脂肪酸，其中亚麻酸在亲水性脂类组合物中的含量以重量比计为30％～99％；所述脂溶性物质B选自下述一种或多种物质：神经酸、DHA、EPA、花生四烯酸、维生素E、维生素A、维生素D、共轭亚油酸、共轭亚油酸甘油酯、磷脂酰丝氨酸、植物甾醇、 植物甾醇酯、植物甾烷醇酯、米糠脂肪烷醇、多烯磷脂酰胆碱，其中脂溶性物质B的含量以重量比计为0.01％～30％，所述亚麻酸包括α-亚麻酸或γ-亚麻酸。Further, the present invention provides a hydrophilic lipid composition containing an emulsifier, a fat-soluble substance A, and a fat-soluble substance B, the emulsifier being selected from one or more of the following: a phospholipid, a sucrose fatty acid ester, Mono, diglycerin fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty acid glyceride, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80, wherein the content of the emulsifier is 0.05% to 8% by weight; the fat-soluble substance A is selected from the group consisting of linolenic acid and one or more of the following substances: oleic acid, sub Oleic acid, medium chain triglyceride, diglyceride, medium long chain fatty acid, wherein the content of linolenic acid in the hydrophilic lipid composition is 30% to 99% by weight; the fat soluble substance B is selected From one or more of the following: nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, plant Sterol, a plant sterol ester, a plant stanol ester, a rice bran fatty alkanol, a polyene phosphatidylcholine, wherein the content of the fat-soluble substance B is 0.01% to 30% by weight, and the linolenic acid comprises α-linolenic acid or Γ-linolenic acid.
进一步的，本发明提供含有乳化剂、脂溶性物质A和脂溶性物质B的亲水性脂类组合物，所述乳化剂选自下述一种或多种物质：磷脂、蔗糖脂肪酸酯、单，双甘油脂肪酸酯、聚甘油脂肪酸酯、丙二醇脂肪酸酯、乳酸脂肪酸甘油酯、吐温20、吐温40、吐温60、吐温80、司盘20、司盘40、司盘60、司盘65、司盘80，其中乳化剂的含量以重量比计为0.05％～8％；所述脂溶性物质A选自亚油酸和下述一种或多种物质：油酸、α-亚麻酸、γ-亚麻酸、中链甘油三酯、甘油二酯、中长链脂肪酸，其中亚油酸在亲水性脂类组合物中的含量以重量比计为30％～99％；所述脂溶性物质B选自下述一种或多种物质：神经酸、DHA、EPA、花生四烯酸、维生素E、维生素A、维生素D、共轭亚油酸、共轭亚油酸甘油酯、磷脂酰丝氨酸、植物甾醇、植物甾醇酯、植物甾烷醇酯、米糠脂肪烷醇、多烯磷脂酰胆碱，其中脂溶性物质B的含量以重量比计为0.01％～30％。Further, the present invention provides a hydrophilic lipid composition containing an emulsifier, a fat-soluble substance A, and a fat-soluble substance B, the emulsifier being selected from one or more of the following: a phospholipid, a sucrose fatty acid ester, Mono, diglycerin fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty acid glyceride, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80, wherein the content of the emulsifier is 0.05% to 8% by weight; the fat-soluble substance A is selected from the group consisting of linoleic acid and one or more of the following substances: oleic acid, Α-linolenic acid, γ-linolenic acid, medium-chain triglyceride, diglyceride, medium-long-chain fatty acid, wherein the content of linoleic acid in the hydrophilic lipid composition is 30% to 99% by weight The fat-soluble substance B is selected from one or more of the following: nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid Glycerides, phosphatidylserine, phytosterols, phytosterol esters, plant stanol esters, rice bran fatty alkanols, polyene phosphorus The fatty choline, wherein the content of the fat-soluble substance B is 0.01% to 30% by weight.
进一步的，本发明提供含有乳化剂、脂溶性物质A和脂溶性物质B的亲水性脂类组合物，所述乳化剂选自下述一种或多种物质：磷脂、蔗糖脂肪酸酯、单，双甘油脂肪酸酯、聚甘油脂肪酸酯、丙二醇脂肪酸酯、乳酸脂肪酸甘油酯、吐温20、吐温40、吐温60、吐温80、司盘20、司盘40、司盘60、司盘65、司盘80，其中乳化剂的含量以重量比计为0.05％～8％；所述脂溶性物质A选自油酸和下述一种或多种物质：亚油酸、α-亚麻酸、γ-亚麻酸、中链甘油三酯、甘油二酯、中长链脂肪酸，其中油酸在亲水性脂类组合物中的含量以重量比计为30％～99％；所述脂溶性物质B选自下述一种或多种物质：神经酸、DHA、EPA、花生四烯酸、维生素E、维生素A、维生素D、共轭亚油酸、共轭亚油酸甘油酯、磷脂酰丝氨酸、植物甾醇、植物甾醇酯、植物甾烷醇酯、米糠脂肪烷醇、多烯磷脂酰胆碱，其中脂溶性物质B的含量以重量比计为0.01％～30％。Further, the present invention provides a hydrophilic lipid composition containing an emulsifier, a fat-soluble substance A, and a fat-soluble substance B, the emulsifier being selected from one or more of the following: a phospholipid, a sucrose fatty acid ester, Mono, diglycerin fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty acid glyceride, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80, wherein the content of the emulsifier is 0.05% to 8% by weight; the fat-soluble substance A is selected from the group consisting of oleic acid and one or more of the following substances: linoleic acid, Α-linolenic acid, γ-linolenic acid, medium chain triglyceride, diglyceride, medium long chain fatty acid, wherein the content of oleic acid in the hydrophilic lipid composition is 30% to 99% by weight; The fat-soluble substance B is selected from one or more of the following: nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glycerin Ester, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phospholipid The choline base, wherein the content of the fat-soluble substance B is 0.01% to 30% by weight.
进一步具体的，本发明提供一种含有乳化剂、中链甘油三酯和脂溶性物质A的亲水性脂类组合物，所述脂溶性物质A选自油酸、亚油酸、α-亚麻酸、γ-亚麻酸、中长链脂肪酸、甘油二酯中的一种或多种，其中中链甘油三酯和脂溶性物质A的含量以重量比计大于45％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.1％～6％，最优选乳化剂的含量以重量比计为0.3％～2.5％。More specifically, the present invention provides a hydrophilic lipid composition containing an emulsifier, a medium chain triglyceride, and a fat-soluble substance A, which is selected from the group consisting of oleic acid, linoleic acid, and α-linen. One or more of acid, γ-linolenic acid, medium-long chain fatty acid, and diglyceride, wherein the content of the medium chain triglyceride and the fat-soluble substance A is more than 45% by weight, and the content of the emulsifier is by weight. The ratio is preferably 0.05% to 8%, preferably the content of the emulsifier is 0.1% to 6% by weight, and most preferably the emulsifier is 0.3% to 2.5% by weight.
进一步具体的，本发明提供一种含有乳化剂、中链甘油三酯和脂溶性物质B的亲水性脂类组合物，所述脂溶性物质B选自神经酸、DHA、EPA、花生四烯酸、维生素E、维生素A、维生素D、共轭亚油酸、共轭亚油酸甘油酯、磷脂酰丝氨酸、植物甾醇、植物甾醇酯、植物甾烷醇酯、米糠脂肪烷醇、多烯磷脂酰胆碱中的一种或多种，其中中链甘油三酯的含量以重量比计为60％～99.5％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.1％～6％，脂溶性物质B的含量以重量比计为0.01％～30％，优选脂溶性物质B的 含量以重量比计为0.05％～25％，优选脂溶性物质B的含量以重量比计为0.01％、0.02％、0.03％、0.04％、0.05％、0.06％、0.07％、0.08％、0.09％、0.1％、0.2％、0.3％、0.4％、0.5％、0.6％、0.7％、0.8％、0.9％、1％、1.1％、1.2％、1.3％、1.4％、1.5％、1.5％、1.6％、1.7％、1.8％、1.9％、2％、2.1％、2.2％、2.3％、2.4％、2.5％、2.6％、2.7％、2.8％、2.9％、3％、3.1％、3.2％、3.3％、3.4％、3.5％、3.6％、3.7％、3.8％、3.9％、4％、4.1％、4.2％、4.3％、4.4％、4.5％、4.6％、4.7％、4.8％、4.9％、5％、5.1％、5.2％、5.3％、5.4％、5.5％、5.6％、5.7％、5.8％、5.9％、6％、6.1％、6.2％、6.3％、6.4％、6.5％、6.6％、6.7％、6.8％、6.9％、7％、7.1％、7.2％、7.3％、7.4％、7.5％、7.6％、7.7％、7.8％、7.9％、8％、8.1％、8.2％、8.3％、8.4％、8.5％、8.6％、8.7％、8.8％、8.9％、9％、9.1％、9.2％、9.3％、9.4％、9.5％、9.6％、9.7％、9.8％、9.9％、10％、11％、12％、13％、14％、15％、16％、17％、18％、19％、20％、21％、22％、23％、24％、25％、26％、27％、28％、29％、30％。More specifically, the present invention provides a hydrophilic lipid composition containing an emulsifier, a medium chain triglyceride, and a fat-soluble substance B, the fat-soluble substance B being selected from the group consisting of nervonic acid, DHA, EPA, and arachidene. Acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phospholipid One or more of choline, wherein the content of the medium chain triglyceride is 60% to 99.5% by weight, and the content of the emulsifier is 0.05% to 8% by weight, preferably the content of the emulsifier. The weight ratio is 0.1% to 6%, and the content of the fat-soluble substance B is 0.01% to 30% by weight, preferably the fat-soluble substance B The content is 0.05% to 25% by weight, and preferably the content of the fat-soluble substance B is 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09% by weight. , 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.5%, 1.6 %, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9% , 5%, 5.1%, 5.2%, 5.3%, 5.4%, 5.5%, 5.6%, 5.7%, 5.8%, 5.9%, 6%, 6.1%, 6.2%, 6.3%, 6.4%, 6.5%, 6.6 %, 6.7%, 6.8%, 6.9%, 7%, 7.1%, 7.2%, 7.3%, 7.4%, 7.5%, 7.6%, 7.7%, 7.8%, 7.9%, 8%, 8.1%, 8.2%, 8.3%, 8.4%, 8.5%, 8.6%, 8.7%, 8.8%, 8.9%, 9%, 9.1%, 9.2%, 9.3%, 9.4%, 9.5%, 9.6%, 9.7%, 9.8%, 9.9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19% 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%.
具体的，本发明提供一种含有乳化剂、神经酸、脂溶性物质A的亲水性脂类组合物，所述脂溶性物质A选自油酸、亚油酸、亚麻酸、中链甘油三酯、中长链脂肪酸、甘油二酯中的一种或多种，脂溶性物质A的含量以重量比计大于45％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.1％～6％，神经酸的含量以重量比计为0.01％～30％，优选神经酸的含量以重量比计为0.01％、0.02％、0.03％、0.04％、0.05％、0.06％、0.07％、0.08％、0.09％、0.1％、0.2％、0.3％、0.4％、0.5％、0.6％、0.7％、0.8％、0.9％、1％、1.1％、1.2％、1.3％、1.4％、1.5％、1.5％、1.6％、1.7％、1.8％、1.9％、2％、2.1％、2.2％、2.3％、2.4％、2.5％、2.6％、2.7％、2.8％、2.9％、3％、3.1％、3.2％、3.3％、3.4％、3.5％、3.6％、3.7％、3.8％、3.9％、4％、4.1％、4.2％、4.3％、4.4％、4.5％、4.6％、4.7％、4.8％、4.9％、5％、5.1％、5.2％、5.3％、5.4％、5.5％、5.6％、5.7％、5.8％、5.9％、6％、6.1％、6.2％、6.3％、6.4％、6.5％、6.6％、6.7％、6.8％、6.9％、7％、7.1％、7.2％、7.3％、7.4％、7.5％、7.6％、7.7％、7.8％、7.9％、8％、8.1％、8.2％、8.3％、8.4％、8.5％、8.6％、8.7％、8.8％、8.9％、9％、9.1％、9.2％、9.3％、9.4％、9.5％、9.6％、9.7％、9.8％、9.9％、10％、11％、12％、13％、14％、15％、16％、17％、18％、19％、20％、21％、22％、23％、24％、25％、26％、27％、28％、29％、30％。Specifically, the present invention provides a hydrophilic lipid composition containing an emulsifier, a nervonic acid, and a fat-soluble substance A, wherein the fat-soluble substance A is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and medium chain glycerin One or more of an ester, a medium long chain fatty acid, and a diglyceride, the content of the fat-soluble substance A is more than 45% by weight, and the content of the emulsifier is 0.05% to 8% by weight, preferably an emulsifier. The content is 0.1% to 6% by weight, and the content of the nerve acid is 0.01% to 30% by weight, and preferably the content of the nerve acid is 0.01%, 0.02%, 0.03%, 0.04% by weight. 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2% , 1.3%, 1.4%, 1.5%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8 %, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5 , 4.6%, 4.7%, 4.8%, 4.9%, 5%, 5.1%, 5.2%, 5.3%, 5.4%, 5.5%, 5.6%, 5.7%, 5.8%, 5.9%, 6%, 6.1%, 6.2 %, 6.3%, 6.4%, 6.5%, 6.6%, 6.7%, 6.8%, 6.9%, 7%, 7.1%, 7.2%, 7.3%, 7.4%, 7.5%, 7.6%, 7.7%, 7.8%, 7.9%, 8%, 8.1%, 8.2%, 8.3%, 8.4%, 8.5%, 8.6%, 8.7%, 8.8%, 8.9%, 9%, 9.1%, 9.2%, 9.3%, 9.4%, 9.5% , 9.6%, 9.7%, 9.8%, 9.9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22 %, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%.
具体的，本发明提供一种含有乳化剂、DHA、脂溶性物质A的亲水性脂类组合物，所述脂溶性物质A选自油酸、亚油酸、亚麻酸、中链甘油三酯、中长链脂肪酸、甘油二酯中的一种或多种，脂溶性物质A的含量以重量比计大于45％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.1％～6％，DHA的含量以重量比计为0.01％～30％，优选DHA的含量以重量比计为0.04％～25％。Specifically, the present invention provides a hydrophilic lipid composition containing an emulsifier, DHA, and a fat-soluble substance A, which is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and medium chain triglyceride. One or more of medium-long chain fatty acids and diglycerides, the content of the fat-soluble substance A is more than 45% by weight, and the content of the emulsifier is 0.05% to 8% by weight, preferably an emulsifier. The content is 0.1% to 6% by weight, and the content of DHA is 0.01% to 30% by weight, and preferably the content of DHA is 0.04% to 25% by weight.
具体的，本发明提供一种含有乳化剂、EPA、脂溶性物质A的亲水性脂类组合物，所述脂溶性物质A选自油酸、亚油酸、亚麻酸、中链甘油三酯、中长链脂肪酸、甘油二酯中的一种或多种，脂溶性物质A的含量以重量比计大于45％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.1％～6％，EPA的含量以重量比计为0.01％～30％，优 选EPA的含量以重量比计为0.04％～25％。Specifically, the present invention provides a hydrophilic lipid composition containing an emulsifier, EPA, and a fat-soluble substance A, which is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and medium chain triglyceride. One or more of medium-long chain fatty acids and diglycerides, the content of the fat-soluble substance A is more than 45% by weight, and the content of the emulsifier is 0.05% to 8% by weight, preferably an emulsifier. The content is 0.1% to 6% by weight, and the EPA content is 0.01% to 30% by weight. The content of EPA is selected to be 0.04% to 25% by weight.
具体的，本发明提供一种含有乳化剂、花生四烯酸、脂溶性物质A的亲水性脂类组合物，所述脂溶性物质A选自油酸、亚油酸、亚麻酸、中链甘油三酯、中长链脂肪酸、甘油二酯中的一种或多种，脂溶性物质A的含量以重量比计大于45％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.1％～6％，花生四烯酸的含量以重量比计为0.01％～30％，优选花生四烯酸的含量以重量比计为0.04％～25％。Specifically, the present invention provides a hydrophilic lipid composition containing an emulsifier, arachidonic acid, and a fat-soluble substance A, wherein the fat-soluble substance A is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and medium chain. One or more of triglyceride, medium long chain fatty acid, and diglyceride, the content of the fat-soluble substance A is more than 45% by weight, and the content of the emulsifier is 0.05% to 8% by weight, preferably The content of the emulsifier is 0.1% to 6% by weight, the content of arachidonic acid is 0.01% to 30% by weight, and the content of arachidonic acid is preferably 0.04% to 25% by weight.
具体的，本发明提供一种含有乳化剂、维生素E、脂溶性物质A的亲水性脂类组合物，所述脂溶性物质A选自油酸、亚油酸、亚麻酸、中链甘油三酯、中长链脂肪酸、甘油二酯中的一种或多种，脂溶性物质A的含量以重量比计大于45％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.1％～6％，维生素E的含量以重量比计为0.01％～30％，优选维生素E的含量以重量比计为0.04％～25％。Specifically, the present invention provides a hydrophilic lipid composition containing an emulsifier, vitamin E, and a fat-soluble substance A, wherein the fat-soluble substance A is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and medium chain glycerin One or more of an ester, a medium long chain fatty acid, and a diglyceride, the content of the fat-soluble substance A is more than 45% by weight, and the content of the emulsifier is 0.05% to 8% by weight, preferably an emulsifier. The content is 0.1% to 6% by weight, and the content of vitamin E is 0.01% to 30% by weight, and preferably the content of vitamin E is 0.04% to 25% by weight.
具体的，本发明提供一种含有乳化剂、共轭亚油酸、脂溶性物质A的亲水性脂类组合物，所述脂溶性物质A选自油酸、亚油酸、亚麻酸、中链甘油三酯、中长链脂肪酸、甘油二酯中的一种或多种，脂溶性物质A的含量以重量比计大于45％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.1％～6％，共轭亚油酸的含量以重量比计为0.01％～25％，优选共轭亚油酸的含量以重量比计为0.04％～20％。Specifically, the present invention provides a hydrophilic lipid composition containing an emulsifier, a conjugated linoleic acid, and a fat-soluble substance A, wherein the fat-soluble substance A is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and the like. One or more of chain triglyceride, medium long chain fatty acid, and diglyceride, the content of the fat-soluble substance A is more than 45% by weight, and the content of the emulsifier is 0.05% to 8% by weight. Preferably, the content of the emulsifier is 0.1% to 6% by weight, the content of the conjugated linoleic acid is 0.01% to 25% by weight, and the content of the conjugated linoleic acid is preferably 0.04% by weight. 20%.
具体的，本发明提供一种含有乳化剂、共轭亚油酸甘油酯、脂溶性物质A的亲水性脂类组合物，所述脂溶性物质A选自油酸、亚油酸、亚麻酸、中链甘油三酯、中长链脂肪酸、甘油二酯中的一种或多种，脂溶性物质A的含量以重量比计大于45％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.1％～6％，共轭亚油酸甘油酯的含量以重量比计为0.01％～25％，优选共轭亚油酸甘油酯的含量以重量比计为0.04％～20％。Specifically, the present invention provides a hydrophilic lipid composition containing an emulsifier, a conjugated linoleic acid glyceride, and a fat-soluble substance A, which is selected from the group consisting of oleic acid, linoleic acid, and linolenic acid. One or more of medium chain triglyceride, medium long chain fatty acid, and diglyceride, the content of the fat-soluble substance A is more than 45% by weight, and the content of the emulsifier is 0.05% to 8 by weight. %, preferably the content of the emulsifier is from 0.1% to 6% by weight, and the content of the conjugated linoleic acid glyceride is from 0.01% to 25% by weight, preferably the content of the conjugated linoleic acid glyceride is by weight. The ratio is 0.04% to 20%.
具体的，本发明提供一种含有乳化剂、磷脂酰丝氨酸、脂溶性物质A的亲水性脂类组合物，所述脂溶性物质A选自油酸、亚油酸、亚麻酸、中链甘油三酯、中长链脂肪酸、甘油二酯中的一种或多种，脂溶性物质A的含量以重量比计大于45％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.1％～6％，磷脂酰丝氨酸的含量以重量比计为0.01％～30％，优选磷脂酰丝氨酸的含量以重量比计为0.04％～25％。Specifically, the present invention provides a hydrophilic lipid composition containing an emulsifier, phosphatidylserine, and a fat-soluble substance A, which is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and medium chain glycerin. One or more of a triester, a medium long chain fatty acid, and a diglyceride, the content of the fat-soluble substance A is more than 45% by weight, and the content of the emulsifier is 0.05% to 8% by weight, preferably emulsified. The content of the agent is from 0.1% to 6% by weight, the content of phosphatidylserine is from 0.01% to 30% by weight, and the content of phosphatidylserine is preferably from 0.04% to 25% by weight.
具体的，本发明提供一种含有乳化剂、多烯磷脂酰胆碱、脂溶性物质A的亲水性脂类组合物，所述脂溶性物质A选自油酸、亚油酸、亚麻酸、中链甘油三酯、中长链脂肪酸、甘油二酯中的一种或多种，脂溶性物质A的含量以重量比计大于45％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.1％～6％，多烯磷脂酰胆碱的含量以重量比计为0.01％～25％，优选多烯磷脂酰胆碱的含量以重量比计为0.04％～25％。Specifically, the present invention provides a hydrophilic lipid composition containing an emulsifier, polyene phosphatidylcholine, and a fat-soluble substance A, wherein the fat-soluble substance A is selected from the group consisting of oleic acid, linoleic acid, and linolenic acid. One or more of medium chain triglyceride, medium long chain fatty acid, and diglyceride, the content of the fat-soluble substance A is more than 45% by weight, and the content of the emulsifier is 0.05% to 8% by weight. Preferably, the content of the emulsifier is 0.1% to 6% by weight, and the content of polyene phosphatidylcholine is 0.01% to 25% by weight, preferably the content of polyene phosphatidylcholine is by weight. 0.04% to 25%.
具体的，本发明提供一种含有乳化剂、植物甾醇、脂溶性物质A的亲水性脂类组合物， 所述脂溶性物质A选自油酸、亚油酸、亚麻酸、中链甘油三酯、中长链脂肪酸、甘油二酯中的一种或多种，脂溶性物质A的含量以重量比计大于45％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.1％～6％，植物甾醇的含量以重量比计为0.01％～30％，优选植物甾醇的含量以重量比计为0.04％～25％。Specifically, the present invention provides a hydrophilic lipid composition containing an emulsifier, phytosterol, and a fat-soluble substance A, The fat-soluble substance A is selected from one or more of oleic acid, linoleic acid, linolenic acid, medium chain triglyceride, medium long chain fatty acid, and diglyceride, and the content of the fat-soluble substance A is in terms of weight ratio. More than 45%, the content of the emulsifier is 0.05% to 8% by weight, preferably the content of the emulsifier is 0.1% to 6% by weight, and the content of phytosterol is 0.01% to 30% by weight. Preferably, the content of phytosterol is from 0.04% to 25% by weight.
具体的，本发明提供一种含有乳化剂、植物甾醇酯、脂溶性物质A的亲水性脂类组合物，所述脂溶性物质A选自油酸、亚油酸、亚麻酸、中链甘油三酯、中长链脂肪酸、甘油二酯中的一种或多种，脂溶性物质A的含量以重量比计大于45％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.1％～6％，植物甾醇酯的含量以重量比计为0.01％～30％，优选植物甾醇酯的含量以重量比计为0.05％～26％。Specifically, the present invention provides a hydrophilic lipid composition containing an emulsifier, a phytosterol ester, and a fat-soluble substance A, which is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and medium chain glycerin. One or more of a triester, a medium long chain fatty acid, and a diglyceride, the content of the fat-soluble substance A is more than 45% by weight, and the content of the emulsifier is 0.05% to 8% by weight, preferably emulsified. The content of the agent is from 0.1% to 6% by weight, and the content of the phytosterol ester is from 0.01% to 30% by weight, preferably from 0.05% to 26% by weight of the phytosterol ester.
具体的，本发明提供一种含有乳化剂、植物甾烷醇酯、脂溶性物质A的亲水性脂类组合物，所述脂溶性物质A选自油酸、亚油酸、亚麻酸、中链甘油三酯、中长链脂肪酸、甘油二酯中的一种或多种，脂溶性物质A的含量以重量比计大于45％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.1％～6％，植物甾烷醇酯的含量以重量比计为0.01％～30％，优选植物甾烷醇酯的含量以重量比计为0.04％～25％。Specifically, the present invention provides a hydrophilic lipid composition containing an emulsifier, a plant stanol ester, and a fat-soluble substance A, wherein the fat-soluble substance A is selected from the group consisting of oleic acid, linoleic acid, linolenic acid, and the like. One or more of chain triglyceride, medium long chain fatty acid, and diglyceride, the content of the fat-soluble substance A is more than 45% by weight, and the content of the emulsifier is 0.05% to 8% by weight. Preferably, the content of the emulsifier is from 0.1% to 6% by weight, and the content of the plant stanol ester is from 0.01% to 30% by weight, preferably the content of the plant stanol ester is 0.04% by weight. 25%.
特别的，本发明提供一种亲水性脂类组合物，含有亚麻酸、乳化剂、脂溶性物质B，所述脂溶性物质B选自神经酸、DHA、EPA、花生四烯酸、维生素E、维生素A、维生素D、共轭亚油酸、共轭亚油酸甘油酯、磷脂酰丝氨酸、植物甾醇、植物甾醇酯、植物甾烷醇酯、米糠脂肪烷醇、多烯磷脂酰胆碱中的一种或多种，所述亚麻酸包括α-亚麻酸或γ-亚麻酸，其中亚麻酸的含量以重量比计为45％～99.5％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.3％～2.5％，脂溶性物质B的含量以重量比计为0.01％～30％，优选脂溶性物质B的含量以重量比计为0.05％～20％，优选脂溶性物质B的含量以重量比计为0.01％、0.02％、0.03％、0.04％、0.05％、0.06％、0.07％、0.08％、0.09％、0.1％、0.2％、0.3％、0.4％、0.5％、0.6％、0.7％、0.8％、0.9％、1％、1.1％、1.2％、1.3％、1.4％、1.5％、1.5％、1.6％、1.7％、1.8％、1.9％、2％、2.1％、2.2％、2.3％、2.4％、2.5％、2.6％、2.7％、2.8％、2.9％、3％、3.1％、3.2％、3.3％、3.4％、3.5％、3.6％、3.7％、3.8％、3.9％、4％、4.1％、4.2％、4.3％、4.4％、4.5％、4.6％、4.7％、4.8％、4.9％、5％、5.1％、5.2％、5.3％、5.4％、5.5％、5.6％、5.7％、5.8％、5.9％、6％、6.1％、6.2％、6.3％、6.4％、6.5％、6.6％、6.7％、6.8％、6.9％、7％、7.1％、7.2％、7.3％、7.4％、7.5％、7.6％、7.7％、7.8％、7.9％、8％、8.1％、8.2％、8.3％、8.4％、8.5％、8.6％、8.7％、8.8％、8.9％、9％、9.1％、9.2％、9.3％、9.4％、9.5％、9.6％、9.7％、9.8％、9.9％、10％、11％、12％、13％、14％、15％、16％、17％、18％、19％、20％、21％、22％、23％、24％、25％、26％、27％、28％、29％、30％。In particular, the present invention provides a hydrophilic lipid composition comprising linolenic acid, an emulsifier, and a fat-soluble substance B, wherein the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, arachidonic acid, and vitamin E. , vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidylcholine One or more of the linolenic acid includes α-linolenic acid or γ-linolenic acid, wherein the content of linolenic acid is 45% to 99.5% by weight, and the content of the emulsifier is 0.05% by weight. 8%, preferably, the content of the emulsifier is 0.3% to 2.5% by weight, and the content of the fat-soluble substance B is 0.01% to 30% by weight, preferably the content of the fat-soluble substance B is 0.05% by weight. ～20%, preferably, the content of the fat-soluble substance B is 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.2%, 0.3 by weight. %, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2% 1.3%, 1.4%, 1.5%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8% 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5 %, 4.6%, 4.7%, 4.8%, 4.9%, 5%, 5.1%, 5.2%, 5.3%, 5.4%, 5.5%, 5.6%, 5.7%, 5.8%, 5.9%, 6%, 6.1%, 6.2%, 6.3%, 6.4%, 6.5%, 6.6%, 6.7%, 6.8%, 6.9%, 7%, 7.1%, 7.2%, 7.3%, 7.4%, 7.5%, 7.6%, 7.7%, 7.8% 7.9%, 8%, 8.1%, 8.2%, 8.3%, 8.4%, 8.5%, 8.6%, 8.7%, 8.8%, 8.9%, 9%, 9.1%, 9.2%, 9.3%, 9.4%, 9.5 %, 9.6%, 9.7%, 9.8%, 9.9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%.
本发明提供一种亲水性脂类组合物，含有亚油酸、乳化剂、脂溶性物质B，所述脂溶性物质B选自神经酸、DHA、EPA、花生四烯酸、维生素E、维生素A、维生素D、共轭亚油酸、 共轭亚油酸甘油酯、磷脂酰丝氨酸、植物甾醇、植物甾醇酯、植物甾烷醇酯、米糠脂肪烷醇、多烯磷脂酰胆碱中的一种或多种，其中亚油酸的含量以重量比计为45％～99％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.3％～2.5％，脂溶性物质B的含量以重量比计为0.01％～30％，优选脂溶性物质B的含量以重量比计为0.04％～25％，优选脂溶性物质B的含量以重量比计为0.06％～23％。The present invention provides a hydrophilic lipid composition comprising linoleic acid, an emulsifier, and a fat-soluble substance B, wherein the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, and vitamins. A, vitamin D, conjugated linoleic acid, One or more of conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidylcholine, wherein linoleic acid is present The weight ratio is 45% to 99%, the content of the emulsifier is 0.05% to 8% by weight, preferably the content of the emulsifier is 0.3% to 2.5% by weight, and the content of the fat-soluble substance B is by weight. The ratio of the fat-soluble substance B is preferably 0.04% to 25% by weight, and preferably the content of the fat-soluble substance B is 0.06% to 23% by weight.
本发明提供一种亲水性脂类组合物，含有油酸、乳化剂、脂溶性物质B，所述脂溶性物质B选自神经酸、DHA、EPA、花生四烯酸、维生素E、维生素A、维生素D、共轭亚油酸、共轭亚油酸甘油酯、磷脂酰丝氨酸、植物甾醇、植物甾醇酯、植物甾烷醇酯、米糠脂肪烷醇、多烯磷脂酰胆碱中的一种或多种，其中油酸的含量以重量比计为45％～99％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.3％～2.5％，脂溶性物质B的含量以重量比计为0.01％～30％，优选脂溶性物质B的含量以重量比计为0.05％～20％。The present invention provides a hydrophilic lipid composition comprising oleic acid, an emulsifier, and a fat-soluble substance B, wherein the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, and vitamin A. , vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidylcholine Or a plurality of, wherein the content of oleic acid is 45% to 99% by weight, the content of the emulsifier is 0.05% to 8% by weight, and preferably the content of the emulsifier is 0.3% to 2.5% by weight. The content of the fat-soluble substance B is 0.01% to 30% by weight, and preferably the content of the fat-soluble substance B is 0.05% to 20% by weight.
本发明提供一种亲水性脂类组合物，含有中链甘油三酯、乳化剂、脂溶性物质B，所述脂溶性物质B选自神经酸、DHA、EPA、花生四烯酸、维生素E、维生素A、维生素D、共轭亚油酸、共轭亚油酸甘油酯、磷脂酰丝氨酸、植物甾醇、植物甾醇酯、植物甾烷醇酯、米糠脂肪烷醇、多烯磷脂酰胆碱中的一种或多种，其中中链甘油三酯的含量以重量比计为40％～99.5％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.1％～6％，脂溶性物质B的含量以重量比计为0.01％～30％，优选脂溶性物质B的含量以重量比计为0.05％～25％。The present invention provides a hydrophilic lipid composition comprising medium chain triglyceride, an emulsifier, and a fat-soluble substance B, wherein the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, arachidonic acid, and vitamin E. , vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidylcholine One or more, wherein the content of the medium chain triglyceride is 40% to 99.5% by weight, and the content of the emulsifier is 0.05% to 8% by weight, preferably the content of the emulsifier is by weight The content of the fat-soluble substance B is from 0.01% to 30% by weight, and the content of the fat-soluble substance B is preferably from 0.05% to 25% by weight.
本发明提供一种亲水性脂类组合物，含有甘油二酯、乳化剂、脂溶性物质B，所述脂溶性物质B选自神经酸、DHA、EPA、花生四烯酸、维生素E、维生素A、维生素D、共轭亚油酸、共轭亚油酸甘油酯、磷脂酰丝氨酸、植物甾醇、植物甾醇酯、植物甾烷醇酯、米糠脂肪烷醇、多烯磷脂酰胆碱中的一种或多种，其中甘油二酯的含量以重量比计为45％～99％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.3％～2.5％，脂溶性物质B的含量以重量比计为0.01％～30％，优选脂溶性物质B的含量以重量比计为0.05％～20％。The present invention provides a hydrophilic lipid composition comprising a diglyceride, an emulsifier, and a fat-soluble substance B, wherein the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, and vitamins. A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidylcholine One or more kinds, wherein the content of the diglyceride is 45% to 99% by weight, the content of the emulsifier is 0.05% to 8% by weight, and the content of the emulsifier is preferably 0.3% by weight. 2.5%, the content of the fat-soluble substance B is 0.01% to 30% by weight, and preferably the content of the fat-soluble substance B is 0.05% to 20% by weight.
本发明提供一种亲水性脂类组合物，含有中长链脂肪酸、乳化剂、脂溶性物质B，所述脂溶性物质B选自神经酸、DHA、EPA、花生四烯酸、维生素E、维生素A、维生素D、共轭亚油酸、共轭亚油酸甘油酯、磷脂酰丝氨酸、植物甾醇、植物甾醇酯、植物甾烷醇酯、米糠脂肪烷醇、多烯磷脂酰胆碱中的一种或多种，其中中长链脂肪酸的含量以重量比计为45％～99％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.3％～2.5％，脂溶性物质B的含量以重量比计为0.01％～30％，优选脂溶性物质B的含量以重量比计为0.05％～20％。The present invention provides a hydrophilic lipid composition comprising a medium long chain fatty acid, an emulsifier, and a fat soluble substance B, wherein the fat soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, Vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidylcholine One or more, wherein the content of the medium long chain fatty acid is 45% to 99% by weight, the content of the emulsifier is 0.05% to 8% by weight, and preferably the content of the emulsifier is 0.3 by weight. % to 2.5%, the content of the fat-soluble substance B is 0.01% to 30% by weight, and the content of the fat-soluble substance B is preferably 0.05% to 20% by weight.
本发明提供一种亲水性脂类组合物，含有油酸、亚油酸、乳化剂、脂溶性物质B，所述 脂溶性物质B选自神经酸、DHA、EPA、花生四烯酸、维生素E、维生素A、维生素D、共轭亚油酸、共轭亚油酸甘油酯、磷脂酰丝氨酸、植物甾醇、植物甾醇酯、植物甾烷醇酯、米糠脂肪烷醇、多烯磷脂酰胆碱中的一种或多种，其中油酸和亚油酸的总含量以重量比计为45％～99％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.1％～6％，脂溶性物质B的含量以重量比计为0.01％～30％，优选脂溶性物质B的含量以重量比计为0.05％～20％。The present invention provides a hydrophilic lipid composition comprising oleic acid, linoleic acid, an emulsifier, and a fat-soluble substance B, The fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol One or more of ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidylcholine, wherein the total content of oleic acid and linoleic acid is 45% to 99% by weight, emulsifier The content is 0.05% to 8% by weight, preferably the content of the emulsifier is 0.1% to 6% by weight, and the content of the fat-soluble substance B is 0.01% to 30% by weight, preferably a fat-soluble substance. The content of B is 0.05% to 20% by weight.
本发明提供一种亲水性脂类组合物，含有亚麻酸、亚油酸、乳化剂、脂溶性物质B，所述脂溶性物质B选自神经酸、DHA、EPA、花生四烯酸、维生素E、维生素A、维生素D、共轭亚油酸、共轭亚油酸甘油酯、磷脂酰丝氨酸、植物甾醇、植物甾醇酯、植物甾烷醇酯、米糠脂肪烷醇、多烯磷脂酰胆碱中的一种或多种，其中亚麻酸和亚油酸的总含量以重量比计为45％～99％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.1％～6％，脂溶性物质B的含量以重量比计为0.01％～30％，优选脂溶性物质B的含量以重量比计为0.05％～20％。The present invention provides a hydrophilic lipid composition comprising linolenic acid, linoleic acid, an emulsifier, and a fat-soluble substance B, wherein the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, arachidonic acid, and vitamins. E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidylcholine One or more of the following, wherein the total content of linolenic acid and linoleic acid is 45% to 99% by weight, and the content of the emulsifier is 0.05% to 8% by weight, preferably the content of the emulsifier is The weight ratio is from 0.1% to 6%, and the content of the fat-soluble substance B is from 0.01% to 30% by weight, and preferably the content of the fat-soluble substance B is from 0.05% to 20% by weight.
本发明提供一种亲水性脂类组合物，含有亚麻酸、中链甘油三酯、乳化剂、脂溶性物质B，所述脂溶性物质B选自神经酸、DHA、EPA、花生四烯酸、维生素E、维生素A、维生素D、共轭亚油酸、共轭亚油酸甘油酯、磷脂酰丝氨酸、植物甾醇、植物甾醇酯、植物甾烷醇酯、米糠脂肪烷醇、多烯磷脂酰胆碱中的一种或多种，其中亚麻酸和中链甘油三酯的总含量以重量比计为45％～99％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.1％～6％，脂溶性物质B的含量以重量比计为0.01％～30％，优选脂溶性物质B的含量以重量比计为0.05％～20％。The present invention provides a hydrophilic lipid composition comprising linolenic acid, medium chain triglyceride, emulsifier, fat-soluble substance B, and the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, and arachidonic acid. , vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidyl One or more of choline, wherein the total content of linolenic acid and medium chain triglyceride is 45% to 99% by weight, and the content of the emulsifier is 0.05% to 8% by weight, preferably emulsified The content of the agent is from 0.1% to 6% by weight, and the content of the fat-soluble substance B is from 0.01% to 30% by weight, and preferably the content of the fat-soluble substance B is from 0.05% to 20% by weight.
本发明提供一种亲水性脂类组合物，含有亚油酸、中链甘油三酯、乳化剂、脂溶性物质B，所述脂溶性物质B选自神经酸、DHA、EPA、花生四烯酸、维生素E、维生素A、维生素D、共轭亚油酸、共轭亚油酸甘油酯、磷脂酰丝氨酸、植物甾醇、植物甾醇酯、植物甾烷醇酯、米糠脂肪烷醇、多烯磷脂酰胆碱中的一种或多种，其中亚油酸和中链甘油三酯的总含量以重量比计为45％～99％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.1％～6％，脂溶性物质B的含量以重量比计为0.01％～30％，优选脂溶性物质B的含量以重量比计为0.05％～20％。The present invention provides a hydrophilic lipid composition comprising linoleic acid, medium chain triglyceride, emulsifier, fat-soluble substance B, and the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, and arachidene. Acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phospholipid One or more of choline, wherein the total content of linoleic acid and medium chain triglyceride is 45% to 99% by weight, and the content of emulsifier is 0.05% to 8% by weight. Preferably, the content of the emulsifier is 0.1% to 6% by weight, the content of the fat-soluble substance B is 0.01% to 30% by weight, and preferably the content of the fat-soluble substance B is 0.05% to 20% by weight. .
本发明提供一种亲水性脂类组合物，含有中链甘油三酯、亚油酸、亚麻酸、乳化剂、脂溶性物质B，所述脂溶性物质B选自神经酸、DHA、EPA、花生四烯酸、维生素E、维生素A、维生素D、共轭亚油酸、共轭亚油酸甘油酯、磷脂酰丝氨酸、植物甾醇、植物甾醇酯、植物甾烷醇酯、米糠脂肪烷醇、多烯磷脂酰胆碱中的一种或多种，其中中链甘油三酯、亚油酸和亚麻酸的总含量以重量比计为45％～99％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.1％～6％，脂溶性物质B的含量以重量比计为0.01％～30％， 优选脂溶性物质B的含量以重量比计为0.05％～20％。The present invention provides a hydrophilic lipid composition comprising medium chain triglyceride, linoleic acid, linolenic acid, an emulsifier, and a fat-soluble substance B, wherein the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, Arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, One or more of polyene phosphatidylcholines, wherein the total content of medium chain triglyceride, linoleic acid and linolenic acid is 45% to 99% by weight, and the content of emulsifier is by weight 0.05% to 8%, preferably the content of the emulsifier is 0.1% to 6% by weight, and the content of the fat-soluble substance B is 0.01% to 30% by weight. The content of the fat-soluble substance B is preferably 0.05% to 20% by weight.
本发明提供一种亲水性脂类组合物，含有中链甘油三酯、亚麻酸、亚油酸、油酸、乳化剂、脂溶性物质B，所述脂溶性物质B选自神经酸、DHA、EPA、花生四烯酸、维生素E、维生素A、维生素D、共轭亚油酸、共轭亚油酸甘油酯、磷脂酰丝氨酸、植物甾醇、植物甾醇酯、植物甾烷醇酯、米糠脂肪烷醇、多烯磷脂酰胆碱中的一种或多种，其中中链甘油三酯、亚麻酸、亚油酸和油酸的总含量以重量比计为45％～99％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.1％～6％，脂溶性物质B的含量以重量比计为0.01％～30％，优选脂溶性物质B的含量以重量比计为0.05％～20％。The present invention provides a hydrophilic lipid composition comprising medium chain triglyceride, linolenic acid, linoleic acid, oleic acid, emulsifier, fat-soluble substance B, and the fat-soluble substance B is selected from the group consisting of nervonic acid and DHA. , EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fat One or more of an alkanol or a polyene phosphatidylcholine, wherein the total content of medium chain triglyceride, linolenic acid, linoleic acid and oleic acid is 45% to 99% by weight, and the emulsifier is The content is 0.05% to 8% by weight, preferably the content of the emulsifier is 0.1% to 6% by weight, and the content of the fat-soluble substance B is 0.01% to 30% by weight, preferably the fat-soluble substance B. The content is 0.05% to 20% by weight.
本发明提供一种亲水性脂类组合物，含有中链甘油三酯、中长链脂肪酸、乳化剂、脂溶性物质B，所述脂溶性物质B选自神经酸、DHA、EPA、花生四烯酸、维生素E、维生素A、维生素D、共轭亚油酸、共轭亚油酸甘油酯、磷脂酰丝氨酸、植物甾醇、植物甾醇酯、植物甾烷醇酯、米糠脂肪烷醇、多烯磷脂酰胆碱中的一种或多种，其中中链甘油三酯和中长链脂肪酸的总含量以重量比计为45％～99％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.1％～6％，脂溶性物质B的含量以重量比计为0.01％～30％，优选脂溶性物质B的含量以重量比计为0.05％～20％。The present invention provides a hydrophilic lipid composition comprising medium chain triglyceride, medium long chain fatty acid, emulsifier, fat soluble substance B, and the fat soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, and peanut. Acrylic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene One or more of phosphatidylcholines, wherein the total content of medium chain triglyceride and medium long chain fatty acid is 45% to 99% by weight, and the content of emulsifier is 0.05% to 8 by weight. %, preferably, the content of the emulsifier is 0.1% to 6% by weight, the content of the fat-soluble substance B is 0.01% to 30% by weight, and the content of the fat-soluble substance B is preferably 0.05% by weight. 20%.
本发明提供一种亲水性脂类组合物，含有中链甘油三酯、甘油二酯、乳化剂、脂溶性物质B，所述脂溶性物质B选自神经酸、DHA、EPA、花生四烯酸、维生素E、维生素A、维生素D、共轭亚油酸、共轭亚油酸甘油酯、磷脂酰丝氨酸、植物甾醇、植物甾醇酯、植物甾烷醇酯、米糠脂肪烷醇、多烯磷脂酰胆碱中的一种或多种，其中中链甘油三酯和甘油二酯的总含量以重量比计为45％～99％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.1％～6％，脂溶性物质B的含量以重量比计为0.01％～30％。The present invention provides a hydrophilic lipid composition comprising medium chain triglyceride, diglyceride, emulsifier, fat-soluble substance B, and the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, and arachidene. Acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phospholipid One or more of choline, wherein the total content of medium chain triglyceride and diglyceride is 45% to 99% by weight, and the content of emulsifier is 0.05% to 8% by weight. The content of the emulsifier is preferably from 0.1% to 6% by weight, and the content of the fat-soluble substance B is from 0.01% to 30% by weight.
本发明提供一种亲水性脂类组合物，含有亚麻酸、甘油二酯、乳化剂、脂溶性物质B，所述脂溶性物质B选自神经酸、DHA、EPA、花生四烯酸、维生素E、维生素A、维生素D、共轭亚油酸、共轭亚油酸甘油酯、磷脂酰丝氨酸、植物甾醇、植物甾醇酯、植物甾烷醇酯、米糠脂肪烷醇、多烯磷脂酰胆碱中的一种或多种，其中亚麻酸和甘油二酯的总含量以重量比计为45％～99％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.1％～6％，脂溶性物质B的含量以重量比计为0.01％～30％，优选脂溶性物质B的含量以重量比计为0.05％～20％。The present invention provides a hydrophilic lipid composition comprising linolenic acid, diglyceride, an emulsifier, and a fat-soluble substance B, wherein the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, arachidonic acid, and vitamins. E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidylcholine One or more of the following, wherein the total content of linolenic acid and diglyceride is 45% to 99% by weight, and the content of the emulsifier is 0.05% to 8% by weight, preferably the content of the emulsifier is The weight ratio is from 0.1% to 6%, and the content of the fat-soluble substance B is from 0.01% to 30% by weight, and preferably the content of the fat-soluble substance B is from 0.05% to 20% by weight.
本发明提供一种亲水性脂类组合物，含有甘油二酯、亚油酸、乳化剂、脂溶性物质B，所述脂溶性物质B选自神经酸、DHA、EPA、花生四烯酸、维生素E、维生素A、维生素D、共轭亚油酸、共轭亚油酸甘油酯、磷脂酰丝氨酸、植物甾醇、植物甾醇酯、植物甾烷醇酯、米糠脂肪烷醇、多烯磷脂酰胆碱中的一种或多种，其中甘油二酯和亚油酸的总含量以重量比计为45％～99％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计 为0.1％～6％，脂溶性物质B的含量以重量比计为0.01％～30％，优选脂溶性物质B的含量以重量比计为0.05％～20％。The present invention provides a hydrophilic lipid composition comprising diglyceride, linoleic acid, an emulsifier, and a fat-soluble substance B, wherein the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, arachidonic acid, Vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidylcholine One or more of the bases, wherein the total content of the diglyceride and the linoleic acid is 45% to 99% by weight, and the content of the emulsifier is 0.05% to 8% by weight, preferably an emulsifier Content by weight The content of the fat-soluble substance B is from 0.01% to 30% by weight, and the content of the fat-soluble substance B is preferably from 0.05% to 20% by weight.
本发明提供一种亲水性脂类组合物，含有甘油二酯、亚油酸、亚麻酸、乳化剂、脂溶性物质B，所述脂溶性物质B选自神经酸、DHA、EPA、花生四烯酸、维生素E、维生素A、维生素D、共轭亚油酸、共轭亚油酸甘油酯、磷脂酰丝氨酸、植物甾醇、植物甾醇酯、植物甾烷醇酯、米糠脂肪烷醇、多烯磷脂酰胆碱中的一种或多种，其中甘油二酯、亚油酸和亚麻酸的总含量以重量比计为45％～99％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.1％～6％，脂溶性物质B的含量以重量比计为0.01％～30％，优选脂溶性物质B的含量以重量比计为0.05％～20％。The present invention provides a hydrophilic lipid composition comprising diglyceride, linoleic acid, linolenic acid, an emulsifier, and a fat-soluble substance B, wherein the fat-soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, and peanut. Acrylic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene One or more of phosphatidylcholine, wherein the total content of diglyceride, linoleic acid and linolenic acid is 45% to 99% by weight, and the content of emulsifier is 0.05% to 8 by weight. %, preferably, the content of the emulsifier is 0.1% to 6% by weight, the content of the fat-soluble substance B is 0.01% to 30% by weight, and the content of the fat-soluble substance B is preferably 0.05% by weight. 20%.
本发明提供一种亲水性脂类组合物，含有中长链脂肪酸、甘油二酯、乳化剂、脂溶性物质B，所述脂溶性物质B选自神经酸、DHA、EPA、花生四烯酸、维生素E、维生素A、维生素D、共轭亚油酸、共轭亚油酸甘油酯、磷脂酰丝氨酸、植物甾醇、植物甾醇酯、植物甾烷醇酯、米糠脂肪烷醇、多烯磷脂酰胆碱中的一种或多种，其中中长链脂肪酸和甘油二酯的总含量以重量比计为45％～99％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.1％～6％，脂溶性物质B的含量以重量比计为0.01％～30％，优选脂溶性物质B的含量以重量比计为0.05％～20％。The present invention provides a hydrophilic lipid composition comprising a medium long chain fatty acid, a diglyceride, an emulsifier, a fat soluble substance B, and the fat soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, and arachidonic acid. , vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidyl One or more of choline, wherein the total content of the medium long chain fatty acid and the diglyceride is 45% to 99% by weight, and the content of the emulsifier is 0.05% to 8% by weight, preferably emulsified. The content of the agent is from 0.1% to 6% by weight, and the content of the fat-soluble substance B is from 0.01% to 30% by weight, and preferably the content of the fat-soluble substance B is from 0.05% to 20% by weight.
本发明提供一种亲水性脂类组合物，含有亚麻酸、中长链脂肪酸、乳化剂、脂溶性物质B，所述脂溶性物质B选自神经酸、DHA、EPA、花生四烯酸、维生素E、维生素A、维生素D、共轭亚油酸、共轭亚油酸甘油酯、磷脂酰丝氨酸、植物甾醇、植物甾醇酯、植物甾烷醇酯、米糠脂肪烷醇、多烯磷脂酰胆碱中的一种或多种，其中亚麻酸和中长链脂肪酸的总含量以重量比计为45％～99％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.1％～6％，脂溶性物质B的含量以重量比计为0.01％～30％，优选脂溶性物质B的含量以重量比计为0.05％～20％。The present invention provides a hydrophilic lipid composition comprising linolenic acid, a medium long chain fatty acid, an emulsifier, and a fat soluble substance B, wherein the fat soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, arachidonic acid, Vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidylcholine One or more of the bases, wherein the total content of the linolenic acid and the medium long-chain fatty acid is 45% to 99% by weight, and the content of the emulsifier is 0.05% to 8% by weight, preferably an emulsifier The content is 0.1% to 6% by weight, and the content of the fat-soluble substance B is 0.01% to 30% by weight, and preferably the content of the fat-soluble substance B is 0.05% to 20% by weight.
本发明提供一种亲水性脂类组合物，含有亚油酸、中长链脂肪酸、乳化剂、脂溶性物质B，所述脂溶性物质B选自神经酸、DHA、EPA、花生四烯酸、维生素E、维生素A、维生素D、共轭亚油酸、共轭亚油酸甘油酯、磷脂酰丝氨酸、植物甾醇、植物甾醇酯、植物甾烷醇酯、米糠脂肪烷醇、多烯磷脂酰胆碱中的一种或多种，其中亚油酸和中长链脂肪酸的总含量以重量比计为45％～99％，乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.1％～6％，脂溶性物质B的含量以重量比计为0.01％～30％，优选脂溶性物质B的含量以重量比计为0.05％～20％。The present invention provides a hydrophilic lipid composition comprising linoleic acid, a medium long chain fatty acid, an emulsifier, a fat soluble substance B, and the fat soluble substance B is selected from the group consisting of nervonic acid, DHA, EPA, and arachidonic acid. , vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidyl One or more of choline, wherein the total content of linoleic acid and medium long-chain fatty acid is 45% to 99% by weight, and the content of emulsifier is 0.05% to 8% by weight, preferably emulsified The content of the agent is from 0.1% to 6% by weight, and the content of the fat-soluble substance B is from 0.01% to 30% by weight, and preferably the content of the fat-soluble substance B is from 0.05% to 20% by weight.
本发明所述乳化剂选自下述一种或多种物质：磷脂、蔗糖脂肪酸酯、单，双甘油脂肪酸酯、聚甘油脂肪酸酯、丙二醇脂肪酸酯、乳酸脂肪酸甘油酯、吐温20、吐温40、吐温60、吐温80、司盘20、司盘40、司盘60、司盘65、司盘80；其中乳化剂的含量以重量比计为 0.05％～8％，优选乳化剂的含量以重量比计为0.1％～6％；The emulsifier of the present invention is selected from one or more of the following: phospholipids, sucrose fatty acid esters, mono-, diglycerin fatty acid esters, polyglycerol fatty acid esters, propylene glycol fatty acid esters, lactic acid fatty acid glycerides, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80; the content of emulsifier is by weight 0.05% to 8%, preferably the content of the emulsifier is 0.1% to 6% by weight;
优选的，所述亲水性脂类组合物中，乳化剂的含量以重量比计为0.07％～7％；Preferably, in the hydrophilic lipid composition, the content of the emulsifier is 0.07% to 7% by weight;
优选的，所述亲水性脂类组合物中，乳化剂的含量以重量比计为0.1％～6％；Preferably, in the hydrophilic lipid composition, the content of the emulsifier is 0.1% to 6% by weight;
优选的，所述亲水性脂类组合物中，乳化剂的含量以重量比计为0.2％～5％；Preferably, in the hydrophilic lipid composition, the content of the emulsifier is 0.2% to 5% by weight;
优选的，所述亲水性脂类组合物中，乳化剂的含量以重量比计为0.3％～4％；Preferably, in the hydrophilic lipid composition, the content of the emulsifier is 0.3% to 4% by weight;
优选的，所述亲水性脂类组合物中，乳化剂的含量以重量比计为0.4％～3.5％；Preferably, in the hydrophilic lipid composition, the content of the emulsifier is 0.4% to 3.5% by weight;
优选的，所述亲水性脂类组合物中，乳化剂的含量以重量比计为0.5％～3％；Preferably, in the hydrophilic lipid composition, the content of the emulsifier is 0.5% to 3% by weight;
优选的，所述亲水性脂类组合物中，乳化剂的含量以重量比计为0.6％～2.5％；Preferably, in the hydrophilic lipid composition, the content of the emulsifier is 0.6% to 2.5% by weight;
优选的，所述亲水性脂类组合物中，乳化剂的含量以重量比计为0.75％～2％；Preferably, in the hydrophilic lipid composition, the content of the emulsifier is 0.75% to 2% by weight;
优选的，所述亲水性脂类组合物中，乳化剂的含量以重量比计为0.8％～1.8％；Preferably, in the hydrophilic lipid composition, the content of the emulsifier is 0.8% to 1.8% by weight;
优选的，所述亲水性脂类组合物中，乳化剂的含量以重量比计为0.85％～1.7％；Preferably, in the hydrophilic lipid composition, the content of the emulsifier is 0.85% to 1.7% by weight;
优选的，所述亲水性脂类组合物中，乳化剂的含量以重量比计为0.9％～1.6％；Preferably, in the hydrophilic lipid composition, the content of the emulsifier is 0.9% to 1.6% by weight;
优选的，所述亲水性脂类组合物中，乳化剂的含量以重量比计为0.95％～1.5％；Preferably, in the hydrophilic lipid composition, the content of the emulsifier is 0.95% to 1.5% by weight;
优选的，所述亲水性脂类组合物中，乳化剂的含量以重量比计为1.0％～1.4％；Preferably, in the hydrophilic lipid composition, the content of the emulsifier is 1.0% to 1.4% by weight;
优选的，所述亲水性脂类组合物中，乳化剂的含量以重量比计为0.4％～1.6％；Preferably, in the hydrophilic lipid composition, the content of the emulsifier is 0.4% to 1.6% by weight;
优选的，所述亲水性脂类组合物中，乳化剂的含量以重量比计为0.5％～1.5％；Preferably, in the hydrophilic lipid composition, the content of the emulsifier is 0.5% to 1.5% by weight;
优选的，所述亲水性脂类组合物中，乳化剂的含量以重量比计为0.6％～1.4％；Preferably, in the hydrophilic lipid composition, the content of the emulsifier is 0.6% to 1.4% by weight;
优选的，所述亲水性脂类组合物中，乳化剂的含量以重量比计为0.7％～1.3％；Preferably, in the hydrophilic lipid composition, the content of the emulsifier is 0.7% to 1.3% by weight;
优选的，所述亲水性脂类组合物中，乳化剂的含量以重量比计为0.8％～1.2％。Preferably, in the hydrophilic lipid composition, the content of the emulsifier is from 0.8% to 1.2% by weight.
其中，所述乳化剂还包括其各种型号、规格、聚合度、酯化度、单/双酯，或其包含的单体成分。具体的，磷脂包括但不限于卵磷脂、磷脂酰乙醇胺、磷脂酰肌醇或磷脂酰甘油，优选的，所述磷脂中的卵磷脂(即磷脂酰胆碱)的含量大于40％，优选所述磷脂中的卵磷脂的含量大于50％；优选所述磷脂中的卵磷脂的含量大于60％；蔗糖脂肪酸酯包括但不限于其S-1至S-16的各种型号；单，双甘油脂肪酸酯包括但不限于单，双硬脂酸甘油酯、单，双油酸甘油酯、单，双月桂酸甘油酯、单，双亚油酸甘油酯、单，双亚麻酸甘油酯、单，双棕榈酸甘油酯、单，双山嵛酸甘油酯；聚甘油脂肪酸酯包括但不限于聚甘油硬脂酸酯、聚甘油油酸酯、聚甘油月桂酸酯、聚甘油肉豆蔻酸酯或聚甘油棕榈酸酯的二聚物、三聚物、 四聚物、六聚物、九聚物，等等，例如包括但不限于三聚甘油硬脂酸酯、三聚甘油油酸酯、三聚甘油月桂酸酯、三聚甘油肉豆蔻酸酯、三聚甘油棕榈酸酯、四聚甘油硬脂酸酯、四聚甘油油酸酯、四聚甘油月桂酸酯、四聚甘油肉豆蔻酸酯、四聚甘油棕榈酸酯、二聚甘油硬脂酸酯、二聚甘油油酸酯、二聚甘油月桂酸酯、二聚甘油肉豆蔻酸酯、二聚甘油棕榈酸酯、六聚甘油硬脂酸酯、九聚甘油硬脂酸酯，等等；丙二醇脂肪酸酯包括但不限于丙二醇油酸酯、丙二醇亚油酸酯、丙二醇硬脂酸酯，等等；乳酸脂肪酸甘油酯包括但不限于油酸、亚油酸、硬脂酸、亚麻酸的乳酸甘油酯，等等。Wherein, the emulsifier further includes various types, specifications, degrees of polymerization, degree of esterification, mono/diester, or monomer components thereof. Specifically, the phospholipids include, but are not limited to, lecithin, phosphatidylethanolamine, phosphatidylinositol or phosphatidylglycerol. Preferably, the content of lecithin (ie, phosphatidylcholine) in the phospholipid is greater than 40%, preferably The content of lecithin in the phospholipid is greater than 50%; preferably, the content of lecithin in the phospholipid is greater than 60%; the sucrose fatty acid esters include, but are not limited to, various models of S-1 to S-16; single, double glycerol Fatty acid esters include, but are not limited to, glyceryl monostearate, mono, diolein, mono, dilauric glyceride, mono, bis linoleate, mono, linolenic glyceride, single , dipalmitin, mono, bis-capric glyceride; polyglycerol fatty acid esters including, but not limited to, polyglyceryl stearate, polyglyceryl oleate, polyglyceryl laurate, polyglyceryl myristate Or dimers, trimers of polyglyceryl palmitate, Tetramers, hexamers, nonamers, and the like, including, but not limited to, triglyceryl stearate, triglyceride oleate, triglyceride laurate, triglycerol myristate, Triglyceride palmitate, tetrapolyglyceryl stearate, tetrapolyglycerol oleate, tetrapolyglycerol laurate, tetrapolyglycerol myristate, tetraglyceride palmitate, diglyceryl stearic acid Esters, diglycerol oleate, diglycerin laurate, diglycerin myristate, diglycerin palmitate, hexaglyceryl stearate, nonaglyceryl stearate, etc.; Propylene glycol fatty acid esters include, but are not limited to, propylene glycol oleate, propylene glycol linoleate, propylene glycol stearate, and the like; lactic acid fatty acid glycerides include, but are not limited to, oleic acid, linoleic acid, stearic acid, linolenic acid Lactic acid glyceride, and so on.
优选的，所述乳化剂为磷脂，其中磷脂的含量以重量比计为0.2％～3.5％，优选磷脂的含量以重量比计为0.5％～2.5％。Preferably, the emulsifier is a phospholipid, wherein the content of the phospholipid is 0.2% to 3.5% by weight, preferably the content of the phospholipid is 0.5% to 2.5% by weight.
优选的，所述乳化剂选自磷脂和下述一种或多种物质：蔗糖脂肪酸酯、单，双甘油脂肪酸酯、聚甘油脂肪酸酯、丙二醇脂肪酸酯、乳酸脂肪酸甘油酯、吐温20、吐温40、吐温60、吐温80、司盘20、司盘40、司盘60、司盘65、司盘80；其中乳化剂的含量以重量比计为0.1％～4％，优选乳化剂的含量以重量比计为0.2％～3％。Preferably, the emulsifier is selected from the group consisting of phospholipids and one or more of the following: sucrose fatty acid esters, mono-, diglycerin fatty acid esters, polyglycerol fatty acid esters, propylene glycol fatty acid esters, lactic acid fatty acid glycerides, spit Temperature 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80; the content of emulsifier is 0.1% to 4% by weight. Preferably, the content of the emulsifier is from 0.2% to 3% by weight.
优选的，所述乳化剂包括蔗糖脂肪酸酯和下述一种或多种物质：磷脂、单，双甘油脂肪酸酯、聚甘油脂肪酸酯、丙二醇脂肪酸酯、乳酸脂肪酸甘油酯、吐温20、吐温40、吐温60、吐温80、司盘20、司盘40、司盘60、司盘65、司盘80；其中乳化剂的含量以重量比计为0.06％～5％，优选乳化剂的含量以重量比计为0.3％～3％。Preferably, the emulsifier comprises a sucrose fatty acid ester and one or more of the following: phospholipid, mono-, diglycerin fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty acid glyceride, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80; the content of emulsifier is 0.06% to 5% by weight. The content of the emulsifier is preferably from 0.3% to 3% by weight.
优选的，所述乳化剂包括单，双甘油脂肪酸酯和下述一种或多种物质：磷脂、蔗糖脂肪酸酯、聚甘油脂肪酸酯、丙二醇脂肪酸酯、乳酸脂肪酸甘油酯、吐温20、吐温40、吐温60、吐温80、司盘20、司盘40、司盘60、司盘65、司盘80；其中乳化剂的含量以重量比计为0.06％～5％，优选乳化剂的含量以重量比计为0.3％～3％。Preferably, the emulsifier comprises a mono-, diglycerin fatty acid ester and one or more of the following: phospholipids, sucrose fatty acid esters, polyglycerol fatty acid esters, propylene glycol fatty acid esters, lactic acid fatty acid glycerides, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80; the content of emulsifier is 0.06% to 5% by weight. The content of the emulsifier is preferably from 0.3% to 3% by weight.
优选的，所述乳化剂包括聚甘油脂肪酸酯和下述一种或多种物质：磷脂、蔗糖脂肪酸酯、单，双甘油脂肪酸酯、丙二醇脂肪酸酯、乳酸脂肪酸甘油酯、吐温20、吐温40、吐温60、吐温80、司盘20、司盘40、司盘60、司盘65、司盘80；其中乳化剂的含量以重量比计为0.06％～5％，优选乳化剂的含量以重量比计为0.3％～3％。Preferably, the emulsifier comprises a polyglycerol fatty acid ester and one or more of the following: phospholipid, sucrose fatty acid ester, mono-, diglycerin fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty acid glyceride, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80; the content of emulsifier is 0.06% to 5% by weight. The content of the emulsifier is preferably from 0.3% to 3% by weight.
优选的，所述乳化剂包括丙二醇脂肪酸酯和下述一种或多种物质：磷脂、蔗糖脂肪酸酯、聚甘油脂肪酸酯、单，双甘油脂肪酸酯、乳酸脂肪酸甘油酯、吐温20、吐温40、吐温60、吐温80、司盘20、司盘40、司盘60、司盘65、司盘80；其中乳化剂的含量以重量比计为0.06％～5％，优选乳化剂的含量以重量比计为0.3％～3％。Preferably, the emulsifier comprises a propylene glycol fatty acid ester and one or more of the following: phospholipids, sucrose fatty acid esters, polyglycerol fatty acid esters, mono-, diglycerin fatty acid esters, lactic acid fatty acid glycerides, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80; the content of emulsifier is 0.06% to 5% by weight. The content of the emulsifier is preferably from 0.3% to 3% by weight.
优选的，所述乳化剂包括乳酸脂肪酸甘油酯和下述一种或多种物质：磷脂、蔗糖脂肪酸酯、聚甘油脂肪酸酯、单，双甘油脂肪酸酯、丙二醇脂肪酸酯、吐温20、吐温40、吐温60、吐温80、司盘20、司盘40、司盘60、司盘65、司盘80；其中乳化剂的含量以重量比 计为0.06％～5％，优选乳化剂的含量以重量比计为0.3％～3％。Preferably, the emulsifier comprises lactic acid fatty acid glyceride and one or more of the following: phospholipid, sucrose fatty acid ester, polyglycerin fatty acid ester, mono, diglycerin fatty acid ester, propylene glycol fatty acid ester, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80; emulsifier content by weight ratio The content of the emulsifier is preferably from 0.3% to 3% by weight, and is preferably from 0.3% to 3% by weight.
具体的，优选本发明所述乳化剂的含量以重量比计为0.05％、0.06％、0.07％、0.08％、0.09％、0.1％、0.2％、0.3％、0.4％、0.5％、0.6％、0.7％、0.8％、0.9％、1％、1.1％、1.2％、1.3％、1.4％、1.5％、1.5％、1.6％、1.7％、1.8％、1.9％、2％、2.1％、2.2％、2.3％、2.4％、2.5％、2.6％、2.7％、2.8％、2.9％、3％、3.1％、3.2％、3.3％、3.4％、3.5％、3.6％、3.7％、3.8％、3.9％、4％、4.1％、4.2％、4.3％、4.4％、4.5％、4.6％、4.7％、4.8％、4.9％、5％、5.1％、5.2％、5.3％、5.4％、5.5％、5.6％、5.7％、5.8％、5.9％、6％、6.1％、6.2％、6.3％、6.4％、6.5％、6.6％、6.7％、6.8％、6.9％、7％、7.1％、7.2％、7.3％、7.4％、7.5％、7.6％、7.7％、7.8％、7.9％或8％。Specifically, it is preferred that the content of the emulsifier of the present invention is 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6% by weight, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2% , 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9 %, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5%, 5.1%, 5.2%, 5.3%, 5.4%, 5.5%, 5.6%, 5.7%, 5.8%, 5.9%, 6%, 6.1%, 6.2%, 6.3%, 6.4%, 6.5%, 6.6%, 6.7%, 6.8%, 6.9%, 7%, 7.1%, 7.2% , 7.3%, 7.4%, 7.5%, 7.6%, 7.7%, 7.8%, 7.9% or 8%.
优选的，本发明所述磷脂，优选磷脂中的卵磷脂(即磷脂酰胆碱)的含量大于40％，优选所述磷脂中的卵磷脂的含量大于50％；优选所述磷脂中的卵磷脂的含量大于60％。Preferably, the phospholipid of the present invention, preferably the lecithin (ie phosphatidylcholine) in the phospholipid is greater than 40%, preferably the lecithin in the phospholipid is greater than 50%; preferably the lecithin in the phospholipid The content is more than 60%.
具体的，优选所述磷脂选自大豆磷脂、大豆卵磷脂、蛋黄磷脂、蛋黄卵磷脂或磷虾油。Specifically, it is preferred that the phospholipid is selected from the group consisting of soybean phospholipids, soy lecithin, egg yolk phospholipids, egg yolk lecithin or krill oil.
进一步的，本发明亲水性的脂类组合物中，还可以含有其它一种或多种功能成分，例如包括但不限于叶黄素、叶黄素酯、辅酶Q10、胡萝卜素、虾青素、番茄红素、大豆异黄酮、植物提取物或蜂胶。例如，特殊的，脂化虾青素含量大于500mg/kg的磷虾油，可作为虾青素的供体油脂应用于本发明亲水性的脂类组合物中。Further, the hydrophilic lipid composition of the present invention may further contain other one or more functional ingredients, such as, but not limited to, lutein, lutein ester, coenzyme Q10, carotene, astaxanthin. , lycopene, soy isoflavones, plant extracts or propolis. For example, a special krill oil having a lipidated astaxanthin content of more than 500 mg/kg can be used as a donor fat of astaxanthin in the hydrophilic lipid composition of the present invention.
进一步的，所述本发明亲水性的脂类组合物中，还可以含有口味改良的成分，例如包括但不限于食用香料或食用香精，甜味剂，例如甜菊糖苷、甘草甜素、三氯蔗糖，等等。Further, the hydrophilic lipid composition of the present invention may further contain taste-improving ingredients such as, but not limited to, flavors or flavors, sweeteners such as stevioside, glycyrrhizin, trichloro Sucrose, and so on.
本发明所述的亲水性脂类组合物，具有优秀的亲水性，它在水基液体中，经振晃，可快速形成均一、稳定的乳浊液；The hydrophilic lipid composition of the invention has excellent hydrophilicity, and can vibrate in a water-based liquid to rapidly form a uniform and stable emulsion;
或者，本发明所述的亲水性脂类组合物，具有优秀的亲水性，它在含有乙醇的水基液体中，经振晃，可快速形成均一、稳定的乳浊液。Alternatively, the hydrophilic lipid composition of the present invention has excellent hydrophilicity, and it can rapidly form a uniform and stable emulsion by shaking in a water-based liquid containing ethanol.
本发明所述水基液体，包括水、含水量大于60％的液体，或者含有乙醇的水溶液。The water-based liquid of the present invention comprises water, a liquid having a water content of more than 60%, or an aqueous solution containing ethanol.
本发明所述振晃，是指通过振动、摇晃或晃动的操作方法，使混合物在容器中产生快速流动、翻滚或/和碰撞冲击的运动，包括使用者用手使混合物产生振晃，或者，采用机器操作使混合物产生振晃，例如采用机械手的操作。The vibration of the present invention refers to a movement of a mixture which causes rapid flow, tumbling or/and impact impact in a container by vibration, shaking or shaking, including the user shaking the mixture by hand, or Machine operation is used to oscillate the mixture, for example by robotic operation.
本发明所述的液体脂肪，包括在常温常压下呈现液态的脂肪酸或油脂，优选包括饱和或不饱和的脂肪酸、饱和或不饱和的油脂、饱和或不饱和的脂肪酸的甘油三酯、饱和或不饱和的脂肪酸的甘油二酯，例如包括但不限于油酸、亚油酸、α-亚麻酸、γ-亚麻酸、中链甘油三酯、甘油二酯、中长链脂肪酸，等等。The liquid fat of the present invention comprises a fatty acid or fat which exhibits a liquid state at normal temperature and pressure, preferably comprising a saturated or unsaturated fatty acid, a saturated or unsaturated fat, a triglyceride of a saturated or unsaturated fatty acid, a saturated or Diglycerides of unsaturated fatty acids include, for example, but are not limited to, oleic acid, linoleic acid, alpha-linolenic acid, gamma-linolenic acid, medium chain triglycerides, diglycerides, medium long chain fatty acids, and the like.
乳浊液是一个复杂的、热力学稳定体系，尤其是不同的油脂类型或脂溶性组分，由于 各组分的脂-水分布和结合能态各异，对于整个体系的稳定性是至关重要的，多组分的脂乳体系，很容易出现脂肪上浮、絮凝或分层等不稳定现象，生产方法和工艺，决定着乳浊液中脂肪球的形态与大小，以及是否会发生聚集等微观现象，从而影响宏观层面上乳液的脂肪上浮、絮凝或分层等不稳定，另外，也影响着乳浊液对人体的消化吸收和利用。Emulsion is a complex, thermodynamically stable system, especially different oil types or fat-soluble components, due to The lipid-water distribution and binding energy state of each component are different, which is crucial for the stability of the whole system. The multi-component milk system is prone to instability such as fat floating, flocculation or delamination. The production method and process determine the shape and size of the fat globule in the emulsion, and whether microscopic phenomena such as aggregation occur, which affects the instability of the fat floating, flocculation or stratification of the emulsion on the macroscopic level, and also affects The absorption, absorption and utilization of the emulsion by the human body.
然而，不利的是，乳化剂与植物油混合后，于常温或略低于常温的环境下，久置会使油脂变浑浊，例如磷脂会析出沉淀，严重影响产品的品质。发明人经过研究，发生此种现象的原因是由于乳化剂不易于与植物油共混，例如磷脂的凝固点高于植物油的凝固点，使得无法与植物油共混的磷脂，在低于其凝固点的温度下会析出沉淀，从而导致油脂变浑浊，或者磷脂会析出沉淀。However, it is disadvantageous that after the emulsifier is mixed with the vegetable oil, the environment may be turbid for a long time at a normal temperature or slightly lower than the normal temperature. For example, the phospholipid may precipitate and seriously affect the quality of the product. The inventors have studied that the reason for this phenomenon is that the emulsifier is not easily blended with vegetable oils, for example, the freezing point of phospholipids is higher than the freezing point of vegetable oil, so that phospholipids that cannot be blended with vegetable oil will be at a temperature lower than the freezing point thereof. The precipitate precipitates, causing the oil to become cloudy, or the phospholipids will precipitate.
因此，本发明亲水性脂类组合物的制备方法是至关重要的，发明人发现，通过加热、高速混合使乳化剂与植物油产生共混、互溶状态，使之分布均匀，并进一步快速、精准降温，或者形成油-气混溶的组合物，使乳化剂分子在迅速降温时，在高分散状态下乳化剂分子会形成小分子微晶态的胶体溶液，达到乳化剂与植物油的稳定共混体。Therefore, the preparation method of the hydrophilic lipid composition of the present invention is crucial, and the inventors have found that the emulsifier and the vegetable oil are blended and miscible by heating and high-speed mixing, so that the distribution is uniform and further rapid, Precise cooling, or oil-gas-miscible composition, when the emulsifier molecules are rapidly cooled, the emulsifier molecules will form a small molecule microcrystalline colloidal solution in a highly dispersed state, achieving a stable emulsifier and vegetable oil. Mixed.
进一步的，本发明提供上述的亲水性脂类组合物的一种制备方法，它包括：Further, the present invention provides a preparation method of the above hydrophilic lipid composition, which comprises:
(1)配料：按配方称取乳化剂、液体脂肪、其它脂溶性物质，定容至所需生产量，搅拌混合、分散均匀；(1) Ingredients: Weigh the emulsifier, liquid fat and other fat-soluble substances according to the formula, and dilute to the required production amount, stir and mix, and disperse evenly;
(2)将(1)中配制好的液体置于乳化罐中，加热使液体温度为45℃以上，于搅拌转速大于500r/min的条件下，优选于搅拌转速大于1000r/min的条件下，进行搅拌操作3～25min，然后在3～5min内迅速将液体冷却至25℃以下，停止搅拌，静置；或者，将(1)中配制好的液体置于乳化罐中，加热使液体温度为45℃以上，于均质机中进行压力为20～58MPa的均质，然后在3～5min内迅速将液体冷却至25℃以下，停止搅拌；(2) placing the liquid prepared in (1) in an emulsification tank, heating to make the liquid temperature above 45 ° C, and at a stirring speed of more than 500 r / min, preferably at a stirring speed of more than 1000 r / min, Stir the operation for 3 to 25 minutes, then quickly cool the liquid to below 25 ° C within 3 to 5 minutes, stop stirring, and let stand; or, place the liquid prepared in (1) in an emulsion tank, and heat to make the liquid temperature Above 45 ° C, the pressure is 20 ~ 58MPa homogenization in the homogenizer, and then quickly cooled the liquid to below 25 ° C within 3 ~ 5min, stop stirring;
(3)灌装：将油状液体进行真空脱气，灌装，封口，包装、检验，即得本发明亲水性脂类组合物。(3) Filling: The oily liquid is vacuum degassed, filled, sealed, packaged and inspected to obtain the hydrophilic lipid composition of the present invention.
本发明上述方法制备的亲水性脂类组合物，通常呈淡黄色至深黄色的透明油状物。进一步的，将亲水性脂类组合物与水基液体通过振晃而调配成乳浊液。The hydrophilic lipid composition prepared by the above method of the present invention is usually a pale yellow to dark yellow transparent oil. Further, the hydrophilic lipid composition and the water-based liquid are blended into an emulsion by shaking.
对于本发明所述的亲水性脂类组合物，与水基液体的亲和性和分散性是至关重要的，本发明创造性的采用油-气混溶的组合物制备方法，对于乳化剂在液体脂肪中产生共混，以及对于脂类组合物的亲水性都具有良好的提高作用。进一步的，本发明提供了亲水性脂类组合物的第二种制备方法，它包括：For the hydrophilic lipid composition of the present invention, the affinity and dispersibility with the water-based liquid are critical, and the inventive method for preparing an oil-gas miscible composition for an emulsifier Blending is produced in the liquid fat and has a good effect on the hydrophilicity of the lipid composition. Further, the present invention provides a second preparation method of a hydrophilic lipid composition, which comprises:
(1)配料：按配方称取乳化剂、液体脂肪、其它脂溶性物质，定容至所需生产量，搅拌混合、分散均匀； (1) Ingredients: Weigh the emulsifier, liquid fat and other fat-soluble substances according to the formula, and dilute to the required production amount, stir and mix, and disperse evenly;
(2)将(1)中配制好的液体置于乳化罐中，向油状液体中持续通入氮气或者保持乳化罐中的压强大于1.3大气压，并于搅拌转速大于300r/min的条件下进行搅拌操作3～25min，使油状液体呈现非透明状的富含氮气的泡沫型的油状液体，停止搅拌；(2) placing the liquid prepared in (1) in an emulsification tank, continuously introducing nitrogen into the oily liquid or keeping the pressure in the emulsification tank stronger than 1.3 atm, and stirring at a stirring speed of more than 300 r/min. After operation for 3 to 25 minutes, the oily liquid is rendered as a non-transparent nitrogen-rich foam-like oily liquid, and the stirring is stopped;
(3)灌装：将(2)中制备的油状液体灌装于容器中，视需要对容器进行充入氮气，并使容器中气体压强大于1.2大气压，密封封口，包装、检验，即得亲水性脂类组合物。(3) Filling: Fill the container with the oily liquid prepared in (2), fill the container with nitrogen as needed, and make the gas pressure in the container stronger than 1.2 atmospheres, seal and seal, package and inspect, then get pro Aqueous lipid composition.
本发明上述方法制备的亲水性脂类组合物，是含有氮气的泡沫型油脂物，呈现非透明状，目测可见其中含有细小均匀的气泡，或者液体的油脂中呈现泡沫状。进一步的，将亲水性脂类组合物与水基液体通过振晃而调配成乳浊液。The hydrophilic lipid composition prepared by the above method of the present invention is a foam-type oily substance containing nitrogen gas, which exhibits a non-transparent shape, and it is visually observed that fine or uniform bubbles are contained therein, or the liquid fat or oil exhibits a foamy shape. Further, the hydrophilic lipid composition and the water-based liquid are blended into an emulsion by shaking.
进一步的，本发明提供第三种所述的亲水性脂类组合物的制备方法，它包括：Further, the present invention provides a method for preparing a third of the hydrophilic lipid composition, which comprises:
(1)配料：按配方称取乳化剂、液体脂肪、其它脂溶性物质，待用；(1) Ingredients: Weigh emulsifier, liquid fat, other fat-soluble substances according to the formula, and use;
(2)将液体脂肪和脂溶性物质混合、搅拌，使其混合分散均匀，得到脂溶性物质的混合物；(2) mixing and stirring the liquid fat and the fat-soluble substance, mixing and dispersing uniformly, and obtaining a mixture of the fat-soluble substance;
(3)乳化剂的预混合：取乳化剂及乳化剂重量3～7倍的(2)中制备的脂溶性物质的混合物，置于乳化罐中，向油状液体中持续通入氮气或者保持乳化罐中的压强大于1.3大气压，并于搅拌转速大于300r/min的条件下搅拌，使油状液体呈现非透明状的富含氮气的泡沫型的油状液体，或者油脂呈现泡沫状，停止搅拌；(3) Premixing of emulsifier: a mixture of the emulsifier and the emulsifier 3 to 7 times the weight of the fat-soluble substance prepared in (2), placed in an emulsification tank, continuously passed into the oily liquid or kept emulsified The pressure in the tank is stronger than 1.3 atm, and is stirred at a stirring speed of more than 300 r/min, so that the oily liquid exhibits a non-transparent nitrogen-rich foam-like oily liquid, or the oil is foamy, and the stirring is stopped;
(4)将(3)中配制好的乳化剂的预混合物料置于乳化罐中，加入剩余的脂溶性物质的混合物，向油状液体中持续通入氮气或者保持乳化罐中的压强大于1.3大气压，并于搅拌转速大于300r/min的条件下搅拌，使油状液体呈现非透明状的富含氮气的泡沫型油脂物，停止搅拌；(4) placing the premixed emulsifier prepared in (3) in an emulsification tank, adding a mixture of the remaining fat-soluble substances, continuously introducing nitrogen into the oily liquid or maintaining the pressure in the emulsification tank at 1.3 atmospheres. And stirring at a stirring speed of more than 300r/min, so that the oily liquid exhibits a non-transparent nitrogen-rich foam-type grease, and the stirring is stopped;
(5)灌装：将(4)中制备的油状液体灌装于容器中，视需要对容器进行充入氮气并使容器中气体压强大于1.2大气压，密封封口，包装、检验，即得亲水性脂类组合物。进一步的，将亲水性脂类组合物与水基液体通过振晃而调配成乳浊液。(5) Filling: Fill the container with the oily liquid prepared in (4), fill the container with nitrogen as needed and make the gas pressure in the container stronger than 1.2 atmospheres, seal and seal, package, and test, that is, hydrophilic Fatty lipid composition. Further, the hydrophilic lipid composition and the water-based liquid are blended into an emulsion by shaking.
另一方面的，本发明提供一种含有乳化剂和液体脂肪的亲水性脂类组合物，其特征在于采用上述第一种制备方法、第二种制备方法或第三种制备方法制成。In another aspect, the present invention provides a hydrophilic lipid composition comprising an emulsifier and a liquid fat, which is characterized by being produced by the above first preparation method, the second preparation method or the third preparation method.
进一步的，本发明提供一种泡沫型的亲水性脂类组合物，含有本发明所述的乳化剂、脂溶性物质A、脂溶性物质B和氮气，所述乳化剂选自下述一种或多种物质：磷脂、蔗糖脂肪酸酯、单，双甘油脂肪酸酯、聚甘油脂肪酸酯、丙二醇脂肪酸酯、乳酸脂肪酸甘油酯、吐温20、吐温40、吐温60、吐温80、司盘20、司盘40、司盘60、司盘65、司盘80，其中乳化剂的含量以重量比计为0.05％～8％；所述脂溶性物质A选自下述一种或多种物质：油酸、亚油酸、亚麻酸、中链甘油三酯、甘油二酯、中长链脂肪酸，其中脂溶性物质A的含量以重量比计大于45％；所述脂溶性物质B选自下述一种或多种物质：神经酸、DHA、EPA、 花生四烯酸、维生素E、维生素A、维生素D、共轭亚油酸、共轭亚油酸甘油酯、磷脂酰丝氨酸、植物甾醇、植物甾醇酯、植物甾烷醇酯、米糠脂肪烷醇、多烯磷脂酰胆碱，其中脂溶性物质B的含量以重量比计为0～30％，优选脂溶性物质B的含量以重量比计为0.01％～30％；所述亚麻酸包括α-亚麻酸或γ-亚麻酸，所述中长链脂肪酸包括中链脂肪酸或长链脂肪酸，所述乳化剂还包括其各种型号、规格、聚合度、酯化度、单/双酯，或其包含的单体成分，所述磷脂中卵磷脂的含量大于40％；优选所述乳化剂选自磷脂和下述一种或多种物质：蔗糖脂肪酸酯、单，双甘油脂肪酸酯、聚甘油脂肪酸酯、丙二醇脂肪酸酯、乳酸脂肪酸甘油酯、吐温20、吐温40、吐温60、吐温80、司盘20、司盘40、司盘60、司盘65、司盘80；其中乳化剂的含量以重量比计为0.1％～4％，优选乳化剂的含量以重量比计为0.2％～3％；其制备方法采用上述第二种的制备方法或第三种的制备方法。Further, the present invention provides a foam type hydrophilic lipid composition comprising the emulsifier, the fat-soluble substance A, the fat-soluble substance B and nitrogen gas according to the present invention, the emulsifier being selected from the group consisting of the following Or a variety of substances: phospholipids, sucrose fatty acid esters, mono-, diglycerin fatty acid esters, polyglycerol fatty acid esters, propylene glycol fatty acid esters, lactic acid fatty acid glycerides, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80, wherein the content of the emulsifier is 0.05% to 8% by weight; the fat-soluble substance A is selected from the following one Or a plurality of substances: oleic acid, linoleic acid, linolenic acid, medium chain triglyceride, diglyceride, medium and long chain fatty acid, wherein the content of the fat-soluble substance A is more than 45% by weight; the fat-soluble substance B is selected from one or more of the following: nervonic acid, DHA, EPA, Arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, a polyene phosphatidylcholine wherein the content of the fat-soluble substance B is 0 to 30% by weight, preferably the content of the fat-soluble substance B is 0.01% to 30% by weight; the linolenic acid includes α-linen Acid or γ-linolenic acid, the medium long chain fatty acid includes a medium chain fatty acid or a long chain fatty acid, and the emulsifier further includes various types, specifications, degrees of polymerization, degree of esterification, mono/diester, or inclusion thereof a monomer component having a lecithin content of greater than 40%; preferably the emulsifier is selected from the group consisting of a phospholipid and one or more of the following: sucrose fatty acid ester, mono-, diglycerin fatty acid ester, polyglycerol Fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty acid glyceride, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80; Wherein the content of the emulsifier is from 0.1% to 4% by weight, preferably an emulsifier Weight ratio in an amount of 0.2% to 3%; prepared using preparation method or the third method for preparing the above-described second.
发明人惊喜地发现，本发明提供的亲水性脂类组合物，在水基液体中，经振晃，可很快形成乳浊液，例如，通过振晃的操作，将本发明亲水性脂类组合物与水基液体在封闭的容器中混合，例如在采用瓶盖封闭的饮料瓶中，亲水性脂类组合物与水基液体在容器中的总体积不高于容器总容量的98％的容量空间中，通过用手振晃的方式，剧烈振晃1～3次，本发明脂类组合物与水基液体能够即刻形成乳浊液，该乳浊液静置5min,甚至10min以上，仍保持均一、稳定的乳浊液，极大地方便了消费者或患者调配和食用；另外，该亲水性脂类组合物与水基液体调配形成乳浊液后，即使经较长时间静置而分层后，经轻微摇晃，仍可以分散为乳浊液，并不会影响饮用或食用。发明人将本发明提供的脂类组合物与水基液体在振晃作用下，瞬间形成乳浊液的过程或技术，称之为“油-水瞬混”。The inventors have surprisingly found that the hydrophilic lipid composition provided by the present invention can rapidly form an emulsion by shaking in a water-based liquid, for example, by the operation of shaking, the hydrophilicity of the present invention. The lipid composition is mixed with the water-based liquid in a closed container, for example, in a beverage bottle closed with a cap, the total volume of the hydrophilic lipid composition and the water-based liquid in the container is not higher than the total capacity of the container. In 98% of the capacity space, by vigorous shaking for 1 to 3 times by hand shaking, the lipid composition of the present invention and the water-based liquid can form an emulsion immediately, and the emulsion is allowed to stand for 5 minutes or even 10 minutes. In addition, the uniform and stable emulsion is maintained, which greatly facilitates the preparation and consumption of the consumer or the patient; in addition, the hydrophilic lipid composition is formulated with the water-based liquid to form an emulsion, even after a long period of time. After standing and stratifying, it can be dispersed into an emulsion after slight shaking, and does not affect drinking or eating. The inventors have described the process or technique of instantaneously forming an emulsion by a lipid composition provided by the present invention and a water-based liquid under the action of shaking, which is called "oil-water instantaneous mixing".
应当说明的是，观测乳浊液是否分层，是以发生脂类物质漂浮在水基液体的液面上，并形成脂类物质与水基液体出现清晰的分离状态为标准；另外，在观测时，应当注意区别乳浊液的液面上存在的气泡或泡沫与乳浊液分层的本质区别；通常，本发明亲水性脂类组合物与水基液体在经过振晃而形成乳浊液，都会产生乳浊液的气泡或泡沫，并且产生的气泡或泡沫漂浮在乳浊液的液面上，但这种漂浮的气泡或泡沫并不是乳浊液发生分层，这一现象要注意区别。It should be noted that observing whether the emulsion is stratified is based on the occurrence of a lipid substance floating on the surface of the water-based liquid and forming a clear separation state between the lipid substance and the water-based liquid; Attention should be paid to distinguishing the essential difference between the bubbles or foams present on the liquid surface of the emulsion and the stratification of the emulsion; in general, the hydrophilic lipid composition of the present invention and the water-based liquid are shaken to form opacity. Liquid, will produce bubbles or foam of the emulsion, and the generated bubbles or bubbles float on the surface of the emulsion, but this floating bubble or foam is not the stratification of the emulsion, this phenomenon should be noted the difference.
进一步的，本发明提供了含有乳化剂和液体脂肪的亲水性脂类组合物的使用方法，它包括将亲水性脂类组合物加入水基液体中，经振晃，使其形成乳浊液而进一步使用，例如，优选作为饮用调和油、可饮用健康油等营养治疗的产品的使用方法；Further, the present invention provides a method for using a hydrophilic lipid composition containing an emulsifier and a liquid fat, which comprises adding a hydrophilic lipid composition to a water-based liquid and shaking it to form an opacity. Further used as a liquid, for example, a method of using a product for nutritional treatment such as drinking oil or drinkable health oil;
或者，进一步的，本发明提供了所述的亲水性脂类组合物的使用方法，它包括将本发明所述的亲水性脂类组合物与水基液体混合后，在封闭的容器中经振晃，使其成为乳浊液；Alternatively, further, the present invention provides a method of using the hydrophilic lipid composition comprising mixing the hydrophilic lipid composition of the present invention with a water-based liquid in a closed container. Shake it to make it an emulsion;
其中，所述水基液体包括水、含水量大于60％的液体，或者含有乙醇的水溶液；所述振晃，优选在1秒钟内进行至少1次振晃的频率，并且振晃的时间不少于1秒钟。 Wherein the water-based liquid comprises water, a liquid having a water content of more than 60%, or an aqueous solution containing ethanol; the shaking, preferably at least one shaking time in one second, and the shaking time is not Less than 1 second.
进一步的，本发明提供了含有乳化剂和液体脂肪的亲水性脂类组合物与水基液体的混合调配的方法，包括将脂类组合物与水基液体混合物后进行振晃而形成乳浊液，所述水基液体包括水、含水量大于60％的液体，或者含有乙醇的水溶液。Further, the present invention provides a method for mixing and mixing a hydrophilic lipid composition containing an emulsifier and a liquid fat with a water-based liquid, comprising shaking a mixture of a lipid composition and a water-based liquid to form an opacifier. The liquid, the water-based liquid includes water, a liquid having a water content of more than 60%, or an aqueous solution containing ethanol.
另一方面，本发明提供的含有乳化剂和液体脂肪的亲水性脂类组合物，具有快速的水乳化性能，优选使用调配瓶将本发明亲水性的脂类组合物与调配成乳浊液，特别的，以如下方法作为亲水性脂类组合物与水基液体的快速调配成水乳浊液的方法：将亲水性脂类组合物与水基液体倒入调配瓶中，其中水基液体与亲水性脂类组合物的重量比大于3:1，优选水基液体与亲水性的脂类组合物的重量比大于10:1，使亲水性脂类组合物和水基液体的总体积不超过调配瓶容量的98％，拧紧调配瓶的盖子，用手或机械手将调配瓶于1秒钟内振晃至少1次的频率，使调配瓶振晃不超过10秒钟，尤其使调配瓶振晃不超过5秒钟，调配瓶振晃时，调配瓶每次位移的距离不小于10厘米，并且使混合液向调配瓶的剩余空间运动，优选使混合液向调配瓶的剩余空间运动并冲击调配瓶的盖子，即可形成均一的乳浊液，该乳浊液在室温下静置5min保持均一乳浊液状态，不发生分层；所述调配瓶，包括带盖的玻璃瓶、带盖的塑料瓶、带盖的铝-塑纸盒、带盖的金属容器，例如，高分子PET瓶，高密度聚乙烯瓶瓶，等等；优选调配瓶的容积不大于3升，最优选调配瓶的容积不大于3升，优选调配瓶的容积为2.5升、1.5升、1升、0.9升、0.8升、0.7升、0.6升、0.5升、0.45升、0.4升、0.3升、0.2升、0.15升、0.1升、0.09升、0.08升、0.07升、0.06升、0.05升或0.04升，等等；所述水基液体包括水、含水量大于60％的液体，或者含有乙醇的水溶液。In another aspect, the hydrophilic lipid composition containing an emulsifier and a liquid fat provided by the present invention has rapid water emulsification performance, and the hydrophilic lipid composition of the present invention is preferably formulated into an opacity using a blending bottle. Liquid, in particular, as a method for rapidly formulating a hydrophilic lipid composition with a water-based liquid into an aqueous emulsion by pouring a hydrophilic lipid composition and a water-based liquid into a mixing bottle, wherein The weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 3:1, preferably the weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 10:1, such that the hydrophilic lipid composition and water The total volume of the base liquid does not exceed 98% of the capacity of the blending bottle. Tighten the lid of the blending bottle and shake the blending bottle at least once in 1 second by hand or robot to shake the blending bottle for no more than 10 seconds. In particular, the mixing bottle is shaken for no more than 5 seconds. When the bottle is shaken, the distance of the mixing bottle is not less than 10 cm per movement, and the mixture is moved to the remaining space of the mixing bottle, preferably the mixing solution is adjusted to the bottle. The remaining space moves and impacts the cover of the bottle , a uniform emulsion can be formed, which is allowed to stand at room temperature for 5 minutes to maintain a uniform emulsion state without delamination; the dispensing bottle includes a glass bottle with a lid, a plastic bottle with a lid, Aluminum-plastic carton with lid, metal container with lid, for example, polymer PET bottle, high-density polyethylene bottle, etc.; preferably, the volume of the bottle is not more than 3 liters, and most preferably the volume of the bottle is not more than 3 liters, preferably volume of 2.5 liter, 1.5 liter, 1 liter, 0.9 liter, 0.8 liter, 0.7 liter, 0.6 liter, 0.5 liter, 0.45 liter, 0.4 liter, 0.3 liter, 0.2 liter, 0.15 liter, 0.1 liter 0.09 liters, 0.08 liters, 0.07 liters, 0.06 liters, 0.05 liters or 0.04 liters, etc.; the water-based liquid comprises water, a liquid having a water content greater than 60%, or an aqueous solution containing ethanol.
本发明含有乳化剂和液体脂肪的亲水性脂类组合物，具有意想不到的快速的水乳化性能，对其使用带来极大方便和新奇感。The hydrophilic lipid composition containing the emulsifier and the liquid fat of the invention has unexpected rapid water emulsification performance, and brings great convenience and novelty to its use.
本发明所述的亲水性脂类组合物通过振晃，能够迅速或瞬间在水中分散，具有快速亲水的特性。进一步的，本发明提供了所述的亲水性脂类组合物快速调配成乳浊液的技术方案。一种含有乳化剂、脂溶性物质A和脂溶性物质B的亲水性脂类组合物，所述乳化剂选自下述一种或多种物质：磷脂、蔗糖脂肪酸酯、单，双甘油脂肪酸酯、聚甘油脂肪酸酯、丙二醇脂肪酸酯、乳酸脂肪酸甘油酯、吐温20、吐温40、吐温60、吐温80、司盘20、司盘40、司盘60、司盘65、司盘80，其中乳化剂的含量以重量比计为0.05％～8％，优选乳化剂的含量以重量比计为0.1％～6％；所述脂溶性物质A选自下述一种或多种物质：油酸、亚油酸、α-亚麻酸、γ-亚麻酸、中链甘油三酯、甘油二酯、中长链脂肪酸，其中脂溶性物质A的含量以重量比计大于45％；所述脂溶性物质B选自下述一种或多种物质：神经酸、DHA、EPA、花生四烯酸、维生素E、维生素A、维生素D、共轭亚油酸、共轭亚油酸甘油酯、磷脂酰丝氨酸、植物甾醇、植物甾醇酯、植物甾烷醇酯、米糠脂肪烷醇、多烯磷脂酰胆碱，其中脂溶性物质B的含量以重量比计为0～30％，其特征在于将亲水性脂类组合物与水基液体通过振晃，可在5秒钟之内形成乳浊液，并且所形成的乳浊液静置至少1min，可保持均一 乳浊液状态，不发生分层，其中水基液体与亲水性的脂类组合物的重量比大于3:1，优选水基液体与亲水性的脂类组合物的重量比大于10:1；The hydrophilic lipid composition of the present invention can be rapidly and instantaneously dispersed in water by shaking, and has a property of being fast and hydrophilic. Further, the present invention provides a technical solution for rapidly formulating the hydrophilic lipid composition into an emulsion. A hydrophilic lipid composition comprising an emulsifier, a fat-soluble substance A and a fat-soluble substance B, the emulsifier being selected from one or more of the following: a phospholipid, a sucrose fatty acid ester, a single, a double glycerin Fatty acid esters, polyglycerol fatty acid esters, propylene glycol fatty acid esters, lactic acid fatty acid glycerides, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80, wherein the content of the emulsifier is 0.05% to 8% by weight, preferably the content of the emulsifier is 0.1% to 6% by weight; the fat-soluble substance A is selected from the following one Or a plurality of substances: oleic acid, linoleic acid, α-linolenic acid, γ-linolenic acid, medium chain triglyceride, diglyceride, medium and long-chain fatty acid, wherein the content of the fat-soluble substance A is greater than 45 by weight. %; the fat-soluble substance B is selected from one or more of the following: nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleum Acid glycerides, phosphatidylserine, phytosterols, phytosterol esters, plant stanol esters, rice bran fatty alkanols, The phosphatidylcholine, wherein the content of the fat-soluble substance B is 0 to 30% by weight, characterized in that the hydrophilic lipid composition and the water-based liquid are oscillated by shaking, and can be formed within 5 seconds. Emulsion, and the formed emulsion is allowed to stand for at least 1 min to maintain uniformity In the emulsion state, no delamination occurs, wherein the weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 3:1, preferably the weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 10: 1;
所述水基液体，包括：水、含水量大于60％的液体，或者含有乙醇的水溶液；The water-based liquid comprises: water, a liquid having a water content of more than 60%, or an aqueous solution containing ethanol;
所述振晃，是指通过振动、摇晃或晃动的操作方法，使混合物在容器中产生运动、翻滚或/和碰撞冲击的运动，包括使用者用手使混合物产生振晃，或者，采用机器操作使混合物产生振晃，例如采用机械手的操作。The vibration refers to a movement, a tumbling or/and a collision impact of the mixture in the container by vibration, shaking or shaking, including shaking the mixture by the user by hand, or using a machine operation. The mixture is shaken, for example by the operation of a robot.
所述振晃的速度，优选在1秒钟内进行至少1次振晃的频率；The speed of the shaking is preferably a frequency at which at least one shaking occurs in one second;
所述中长链脂肪酸包括中链脂肪酸或长链脂肪酸；The medium long chain fatty acid comprises a medium chain fatty acid or a long chain fatty acid;
优选的，所述脂溶性物质B的含量以重量比计为0.01％～30％；Preferably, the content of the fat-soluble substance B is 0.01% to 30% by weight;
优选的，其特征在于将亲水性脂类组合物与水基液体通过振晃，可在4秒钟之内形成乳浊液；Preferably, it is characterized in that the hydrophilic lipid composition and the water-based liquid are shaken to form an emulsion within 4 seconds;
优选的，其特征在于将亲水性脂类组合物与水基液体通过振晃，可在3秒钟之内形成乳浊液；Preferably, it is characterized in that the hydrophilic lipid composition and the water-based liquid are shaken to form an emulsion within 3 seconds;
优选的，其特征在于将亲水性脂类组合物与水基液体通过振晃，可在2秒钟之内形成乳浊液；Preferably, it is characterized in that the hydrophilic lipid composition and the water-based liquid are shaken to form an emulsion within 2 seconds;
优选的，其特征在于将亲水性脂类组合物与水基液体通过振晃，可在1秒钟之内形成乳浊液。Preferably, it is characterized in that the hydrophilic lipid composition and the water-based liquid are shaken to form an emulsion within one second.
本发明所述的亲水性脂类组合物，属于脂肪型组合物，为了使用方便、更好吸收，将本发明所述的亲水性脂类组合物在水基的液体形成乳浊液是非常必要的。例如，将本发明提供了所述的亲水性脂类组合物作为各种水基的液体食物的健康食品或饮品伴侣，优选作为匀浆膳、牛奶、饮料、水溶液、果汁、咖啡、流食，如稀饭、米糊、面糊、冲调食品，如冲调麦片、冲调奶粉、冲调咖啡、冲调固体饮料，等等；优选作为可用于水调配的饮用调和油、可饮用健康油；更优选采用水基液体调配成乳浊液使用。The hydrophilic lipid composition of the present invention belongs to a fat type composition, and the hydrophilic lipid composition of the present invention forms an emulsion in a water-based liquid for convenient use and better absorption. very necessary. For example, the present invention provides the hydrophilic lipid composition as a health food or beverage companion for various water-based liquid foods, preferably as a homogenate diet, milk, beverage, aqueous solution, juice, coffee, liquid food, Such as porridge, rice paste, batter, brewed food, such as brewed cereal, brewed milk powder, brewed coffee, brewed solid beverage, etc.; preferably used as a blending oil for drinking water, drinkable healthy oil; It is preferred to use a water-based liquid formulated into an emulsion.
更进一步的，本发明进一步提供了含有本发明所述亲水性脂类组合物与水基液体的包装组合物、该包装组合物调配成乳浊液的方法。Still further, the present invention further provides a packaging composition comprising the hydrophilic lipid composition of the present invention and a water-based liquid, the method of which the packaging composition is formulated into an emulsion.
一种包装组合物，包括将亲水性脂类组合物与水基液体分别独立包装并组合在一起，所述亲水性脂类组合物含有液体脂肪和乳化剂，其中液体脂肪选自下述一种或多种物质：中链甘油三酯、α-亚麻酸、γ-亚麻酸、甘油二酯、油酸、亚油酸、中长链脂肪酸，液体脂肪在亲水性脂类组合物中的含量以重量比计大于45％；A packaging composition comprising separately packaging and combining a hydrophilic lipid composition and a water-based liquid, the hydrophilic lipid composition comprising a liquid fat and an emulsifier, wherein the liquid fat is selected from the group consisting of One or more substances: medium chain triglyceride, α-linolenic acid, γ-linolenic acid, diglyceride, oleic acid, linoleic acid, medium and long-chain fatty acid, liquid fat in hydrophilic lipid composition The content is greater than 45% by weight;
乳化剂选自下述一种或多种物质：磷脂、蔗糖脂肪酸酯、单，双甘油脂肪酸酯、聚甘 油脂肪酸酯、丙二醇脂肪酸酯、乳酸脂肪酸甘油酯、吐温20、吐温40、吐温60、吐温80、司盘20、司盘40、司盘60、司盘65、司盘80，乳化剂在亲水性脂类组合物中的含量以重量比计为0.05％～8％；The emulsifier is selected from one or more of the following: phospholipids, sucrose fatty acid esters, mono-, diglycerin fatty acid esters, polyglycans Oil fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty acid glyceride, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80 The content of the emulsifier in the hydrophilic lipid composition is 0.05% to 8% by weight;
所述水基液体，选自水、含水量大于60％的液体，或者含有乙醇的水溶液；The water-based liquid is selected from the group consisting of water, a liquid having a water content of more than 60%, or an aqueous solution containing ethanol;
所述水基液体与亲水性脂类组合物的重量比大于3:1；The weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 3:1;
所述水基液体与亲水性脂类组合物的体积总和不大于容纳水基液体的容器容量的98％。The sum of the volume of the water-based liquid and the hydrophilic lipid composition is not more than 98% of the capacity of the container containing the water-based liquid.
上述的包装组合物，所述亲水性脂类组合物中进一步含有脂溶性物质B，所述脂溶性物质B选自下述一种或多种物质：神经酸、DHA、EPA、花生四烯酸、维生素E、维生素A、维生素D、共轭亚油酸、共轭亚油酸甘油酯、磷脂酰丝氨酸、植物甾醇、植物甾醇酯、植物甾烷醇酯、米糠脂肪烷醇、多烯磷脂酰胆碱，其中脂溶性物质B在亲水性脂类组合物中的含量以重量比计为0.01％～30％。In the above packaging composition, the hydrophilic lipid composition further contains a fat-soluble substance B selected from one or more of the following substances: nervonic acid, DHA, EPA, and arachidene. Acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phospholipid The choline is a content of the fat-soluble substance B in the hydrophilic lipid composition in an amount of from 0.01% to 30% by weight.
具体的，本发明提供的各种组合、具体成分、配比、制备方法、调配方法的亲水性脂类组合物，均适用于上述包装组合物的亲水性脂类组合物。Specifically, the hydrophilic lipid composition of various combinations, specific components, ratios, preparation methods, and formulation methods provided by the present invention are all applicable to the hydrophilic lipid composition of the above-mentioned packaging composition.
所述包装组合物，包括将本发明所述的亲水性脂类组合物与水基液体分别独立包装并组合在一起，例如形成组合在同一个包装盒或包装袋中，或者例如，将脂类组合物的独立包装与水基液体的独立包装通过粘贴固定、标签固定或包装套件的形式组合在在一起形成包装组合物，所述“通过粘贴固定、标签固定或包装套件的形式组合在一起”，是指通过胶带或粘性胶等方式将脂类组合物的独立包装与水基液体的独立包装组合在一起；或者用脂类组合物的产品标签、水基液体的产品标签，通过标签的捆绑、包裹、缠绕等作用力，将脂类组合物的独立包装与水基液体的独立包装组合在一起；或者将脂类组合物的独立包装与水基液体的独立包装设置成包装套件的方式，组合在一起，例如，在水基液体的容器上设置一个凹槽，将脂类组合物的包装物卡在凹槽中，形成包装套件，或者将脂类组合物独立密封于容器的盖构件的腔室中，将水基液体密封于容器中，并将容器的盖构件安装在容器的开口处对容器进行密封，使得脂类组合物与水基液体各自独立密封，在使用时，将容器的盖构件打开，释放出盖构件中的脂类组合物，与容器中的水基液体混合，进一步，通过振晃而形成均一的乳浊液；例如，所述的容器的盖构件，可参考类似于国际公布WO2007/129126所公开的技术方案。The packaging composition comprises separately packaging and combining the hydrophilic lipid composition of the present invention and a water-based liquid, for example, forming a combination in the same package or packaging, or, for example, a fat Individual packaging of the composition of the composition and individual packaging of the water-based liquid are combined together in the form of a affixing, labeling or packaging kit to form a packaging composition, which is "combined by means of adhesive fastening, label fixing or packaging kit" ", means that the individual packaging of the lipid composition is combined with the independent packaging of the water-based liquid by means of tape or adhesive glue; or the product label of the lipid composition, the product label of the water-based liquid, through the label Bundling, wrapping, winding, etc., combining the individual packaging of the lipid composition with the independent packaging of the water-based liquid; or the independent packaging of the lipid composition and the independent packaging of the water-based liquid into a packaging package , put together, for example, a groove is formed in the container of the water-based liquid, and the package of the lipid composition is stuck in the groove Forming a packaging kit, or separately sealing the lipid composition into the chamber of the lid member of the container, sealing the water-based liquid in the container, and installing the lid member of the container at the opening of the container to seal the container, so that the grease is sealed The composition and the water-based liquid are each independently sealed. When in use, the lid member of the container is opened, the lipid composition in the lid member is released, mixed with the water-based liquid in the container, and further, uniformity is formed by shaking. The emulsion; for example, the cover member of the container can be referred to a technical solution similar to that disclosed in International Publication WO2007/129126.
或者，所述包装组合物中，包括将本发明所述的亲水性脂类组合物独立包装，并与调配瓶同时存在于同一个包装盒单元中，所述调配瓶是带有盖的空瓶，优选调配瓶上标示有需要加入水基液体的量的刻度线，使用时，只需要将亲水性脂类组合物的包装物打开，将亲水性脂类组合物倒入调配瓶中，再加入水基液体，以方便调配、振晃，使脂肪酸组合物很好地在水基液体中形成均一的乳浊液而使用，也方便使用者自行决定加入的亲水性脂类 组合物的量和加入的水基液体的量。Alternatively, the packaging composition comprises separately packaging the hydrophilic lipid composition of the present invention and presenting it in the same package unit simultaneously with the dispensing bottle, the dispensing bottle being empty with a lid The bottle, preferably the adjustment bottle, is marked with a scale line for the amount of water-based liquid to be added. In use, it is only necessary to open the package of the hydrophilic lipid composition and pour the hydrophilic lipid composition into the preparation bottle. The water-based liquid is further added to facilitate the preparation and shaking, so that the fatty acid composition can be well formed into a uniform emulsion in the water-based liquid, and the user can also decide to add the hydrophilic lipid. The amount of the composition and the amount of water-based liquid added.
或者，特殊的情况是，本发明所述的包装组合物，所述包装组合物中，可以没有调配瓶，但是亲水性脂类组合物的包装物的标签上标示有将所述脂类组合物与水基液体通过在容器中混合并将混合液进行振晃而得到乳浊液的内容信息，也是本发明脂类组合物的包装组合物的技术内容，即，亲水性脂类组合物，并且其产品标签上标示有将亲水性脂类组合物与水基液体混合并通过振晃而得到乳浊液的内容。Or, in particular, in the packaging composition of the present invention, the packaging composition may be free of the blending bottle, but the label of the packaging of the hydrophilic lipid composition is marked with the combination of the lipids. The content of the emulsion is obtained by mixing the mixture with the water-based liquid and shaking the mixture, and is also the technical content of the packaging composition of the lipid composition of the present invention, that is, the hydrophilic lipid composition. And the product label is marked with the content of the hydrophilic lipid composition mixed with the water-based liquid and obtained by shaking to obtain an emulsion.
上述包装组合物更方便于脂类组合物与水基液体的组合、储存，更有利于脂类组合物与水基液体的调配使用，所述的亲水性脂类组合物与水基液体调配成乳浊液的方法，包括：将亲水性脂类组合物倒入容纳有水基液体的容器中，其中水基液体与亲水性脂类组合物的重量比大于3:1，使亲水性脂类组合物和水基液体的总体积不超过容器容量的98％，拧紧容器的盖子，用手或机械手将调配瓶于1秒钟内振晃至少1次的频率，使容器振晃不超过10秒钟，容器振晃时，容器每次位移的距离不小于10厘米，并且使混合液向容器的剩余空间运动而形成乳浊液，优选容器振晃时，使混合液向容器的剩余空间运动并冲击调配瓶的盖子；The above packaging composition is more convenient for the combination and storage of the lipid composition and the water-based liquid, and is more advantageous for the preparation of the lipid composition and the water-based liquid, and the hydrophilic lipid composition is mixed with the water-based liquid. The method for forming an emulsion comprises: pouring a hydrophilic lipid composition into a container containing a water-based liquid, wherein a weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 3:1, so that the pro The total volume of the aqueous lipid composition and the water-based liquid does not exceed 98% of the container capacity. Tighten the lid of the container and shake the container at least once in 1 second by hand or robot to shake the container. In less than 10 seconds, when the container is shaken, the container is displaced by a distance of not less than 10 cm each time, and the mixed liquid is moved to the remaining space of the container to form an emulsion, preferably, when the container is shaken, the mixed solution is directed to the container. The remaining space moves and impacts the cover of the bottle;
其中亲水性脂类组合物包括本发明所述的任意一种亲水性脂类组合物；Wherein the hydrophilic lipid composition comprises any of the hydrophilic lipid compositions of the present invention;
所述水基液体，选自水、含水量大于60％的液体，或者含有乙醇的水溶液；The water-based liquid is selected from the group consisting of water, a liquid having a water content of more than 60%, or an aqueous solution containing ethanol;
所述水基液体的容器，选自带盖的玻璃瓶、带盖的塑料瓶、带盖的铝-塑纸盒、带盖的金属容器，并且容器的容积不大于3升。The water-based liquid container is selected from the group consisting of a glass bottle with a lid, a plastic bottle with a lid, an aluminum-plastic paper box with a lid, a metal container with a lid, and a container having a volume of no more than 3 liters.
具体的，本发明所述的水基液体包括但不限于水、碳水化合物的水溶液(例如单糖、双糖、低聚糖、多糖等)、膳食纤维的水溶液(例如菊粉、低聚果糖、聚葡萄糖)、膳食纤维的水混悬液、氨基酸的水溶液、维生素的水溶液、电解质的水溶液(如氯化钾、硫酸镁的水溶液)、益生菌的水溶液或混悬液、动物乳液(如牛奶、羊奶、马奶)、动物蛋白粉的水乳浊液(如牛奶粉、羊奶粉的水乳浊液、精制乳蛋白粉的水乳浊液)、植物蛋白粉的水乳浊液(大豆蛋白粉、花生蛋白粉的水乳浊液)、液体果汁、液体蔬菜汁、植物的水提取液、植物提取物的水溶液或水浊液(例如茶叶或咖啡的水溶液、茶叶或咖啡的水浊液)、匀浆膳、乙醇水溶液(如饮用酒、啤酒、鸡尾酒)，等等。Specifically, the water-based liquids of the present invention include, but are not limited to, water, aqueous solutions of carbohydrates (eg, monosaccharides, disaccharides, oligosaccharides, polysaccharides, etc.), aqueous solutions of dietary fibers (eg, inulin, oligofructose, Polydextrose), aqueous suspension of dietary fiber, aqueous solution of amino acid, aqueous solution of vitamins, aqueous solution of electrolyte (such as aqueous solution of potassium chloride or magnesium sulfate), aqueous solution or suspension of probiotics, animal emulsion (such as milk, Milk emulsion of goat milk, horse milk), animal protein powder (such as milk powder, water emulsion of goat milk powder, water emulsion of refined milk protein powder), water emulsion of vegetable protein powder (soy protein An aqueous emulsion of powder, peanut protein powder), liquid fruit juice, liquid vegetable juice, water extract of plants, aqueous solution of plant extract or water turbid liquid (for example, aqueous solution of tea or coffee, water turbid liquid of tea or coffee) , homogenized diet, aqueous ethanol solution (such as drinking wine, beer, cocktails), and so on.
优选的，本发明所述水基液体选自下述一种或多种物质的水溶液：蔗糖、葡萄糖、果糖、麦芽糖、壳寡糖、低聚果糖、低聚木糖、聚葡萄糖、菊粉、牛磺酸、半胱氨酸、胱氨酸、甘氨酸、天冬氨酸、天冬酰胺、谷氨酸、谷氨酰胺、赖氨酸、精氨酸、鸟氨酸、维生素C、维生素B、左旋肉碱、叶酸、烟酸、胆碱、肌醇；或者，优选的，本发明所述水基液体选自动物乳液、动物蛋白粉的水乳浊液或植物蛋白粉的水乳浊液。Preferably, the water-based liquid of the present invention is selected from the group consisting of an aqueous solution of one or more of the following: sucrose, glucose, fructose, maltose, chitooligosaccharide, oligofructose, xylooligosaccharide, polydextrose, inulin, Taurine, cysteine, cystine, glycine, aspartic acid, asparagine, glutamic acid, glutamine, lysine, arginine, ornithine, vitamin C, vitamin B, L-carnitine, folic acid, nicotinic acid, choline, inositol; or, preferably, the water-based liquid of the present invention is selected from the group consisting of an animal emulsion, an aqueous emulsion of animal protein powder or an aqueous emulsion of vegetable protein powder.
上述水基液体，一方面，不仅提供了水溶性或蛋白类的营养物质，与本发明提供的亲 水性脂类组合物具有营养协同的药理作用，另一方面，上述水基液体更有利于与亲水性脂类组合物在振晃作用下快速形成乳浊液，并保持良好的、不易分层的乳浊液的稳定性。The above water-based liquid, on the one hand, not only provides water-soluble or protein-based nutrients, but also provides the pros provided by the present invention. The aqueous lipid composition has a nutritional synergistic pharmacological effect. On the other hand, the above water-based liquid is more advantageous for rapidly forming an emulsion with a hydrophilic lipid composition under the action of vibration, and maintaining good and not easy to stratify. The stability of the emulsion.
本发明还提供了所述的亲水性脂类组合物适用于药物、特殊医学用途配方食品、保健食品、营养食品或化妆品，等等，一方面，所述亲水性脂类组合物中含有对人体健康和疾病康复作用的不饱和脂肪酸和脂肪类健康成分，尤其适用于制备药物、特殊医学用途配方食品、保健食品、营养食品或化妆品，另一方面，本发明的亲水性脂类组合物属于液体状，可作为油脂类溶剂，对脂溶性的药物进行溶解并进一步可将其调配、分散在水基液体中形成乳浊液使用，以利于脂溶性的药物的口服、吸收和利用，例如，脂溶性的药物包括阿德福韦酯、替诺福韦酯、叶黄素酯、辅酶Q10，等等。另外，用于化妆品时，作为润肤精油、护肤精油、护发精油，或者溶于水作为脸部、皮肤的补水、补油化妆品，以及皮肤营养油乳，等等，用于对皮肤的护理和美容，等等。特别的，本发明所述的亲水性脂类组合物，作为饮用调和油，可饮用健康油等健康、保健、营养治疗的产品。特别的，在制备特殊医学用途配方食品的匀浆膳中的应用。The present invention also provides the hydrophilic lipid composition for use in medicine, special medical use formula, health food, nutraceutical or cosmetic, etc., on the one hand, the hydrophilic lipid composition contains The unsaturated fatty acid and fat health component for rejuvenating human health and disease are especially suitable for preparing medicine, special medical use formula, health food, nutritious food or cosmetics, and on the other hand, the hydrophilic lipid combination of the present invention The substance is in the form of a liquid, and can be used as a solvent for oils and fats, and is soluble in a fat-soluble drug, and can be further formulated and dispersed in a water-based liquid to form an emulsion, thereby facilitating oral administration, absorption and utilization of a fat-soluble drug. For example, fat-soluble drugs include adefovir dipivoxil, tenofovir, lutein, coenzyme Q10, and the like. In addition, when used in cosmetics, it is used as an emollient oil, skin care essential oil, hair care essential oil, or dissolved in water as a hydrating and oil replenishing agent for the face and skin, as well as skin nutrient oil, etc., for skin care. And beauty, and more. In particular, the hydrophilic lipid composition of the present invention can be used as a drinking and blending oil, and can be used for health, health care, and nutritional treatment of health oil. In particular, the use in the preparation of homogenized meals for formulas for special medical uses.
因此，本发明还提供了含有所述乳化剂和液体脂肪的亲水性脂类组合物通过与水基液体混合，并进一步经振晃而调配成乳浊液，在制备或调配药物、特殊医学用途配方食品、保健食品、营养食品或化妆品方面的应用，尤其在制备或调配即时口服摄入的药物、特殊医学用途配方食品、保健食品、营养食品中的应用，或者在制备或调配即时使用的化妆品中的应用，极大的方便使用者的即时调配、即时使用。Therefore, the present invention also provides a hydrophilic lipid composition containing the emulsifier and liquid fat by mixing with a water-based liquid and further oscillating to prepare an emulsion, in the preparation or formulation of a drug, special medicine Uses in formulas, health foods, nutraceuticals or cosmetics, especially in the preparation or deployment of immediate oral intake medications, special medical use formulas, health foods, nutraceuticals, or in the preparation or deployment of ready-to-use The application in cosmetics is very convenient for the user to immediately deploy and use.
本发明还提供了含有乳化剂和液体脂肪的亲水性脂类组合物通过与水基液体混合，经振晃而制备成乳浊液中的应用。The present invention also provides an application of a hydrophilic lipid composition containing an emulsifier and a liquid fat by mixing with a water-based liquid to prepare an emulsion by shaking.
本发明还提供了含有乳化剂和液体脂肪的亲水性脂类组合物通过与水基液体混合，并进一步经振晃而调配成乳浊液，在制备特殊医学用途配方食品食品的匀浆膳中的应用。The invention also provides a homogenate diet for preparing a special medical use formula food by mixing a hydrophilic lipid composition containing an emulsifier and a liquid fat with a water-based liquid and further oscillating to form an emulsion. Application in .
本发明还提供了含有乳化剂和液体脂肪的亲水性脂类组合物通过与水基液体混合，经振晃而制备成乳浊液，而进一步用于餐食制作中的应用，用乳浊液代替餐食制作中的水应用于餐食制作中，包括但不限于制作蒸品食物、煮品食物、调制面粉类食品、拌食各类食品或冲调食品饮料中的应用。The present invention also provides a hydrophilic lipid composition containing an emulsifier and a liquid fat, which is prepared by mixing with a water-based liquid and being shaken to prepare an emulsion, and is further used for the production of meals, using opacity. Liquid instead of water in the production of meals is used in the production of meals, including but not limited to the application of steamed food, cooked food, prepared flour, mixed foods or prepared foods and beverages.
一方面，本发明所述的亲水性脂类组合物，能提供对于人体健康和疾病治疗有益的不饱和脂肪酸，如神经酸、α-亚麻酸、γ-亚麻酸、DHA、EPA、花生四烯酸，等等，以及脂溶性药物或营养物质，如维生素E、中链甘油三酯、磷脂、维生素A、维生素D、叶黄素酯、辅酶Q10，等等；另一方面，本发明乳化剂和脂溶性物质具有良好的药理协同作用，对于人体健康，尤其在口服补充磷脂、不饱和脂肪酸和脂溶性药物等方面，具有良好的协同作用。因此，更进一步的，本发明还提供了含有乳化剂和液体脂肪的亲水性脂类组合物通过与水 基液体混合，经振晃而制备成可供口服饮用的乳浊液，在制备防治心脑血管疾病的药物或特殊食品方面的应用；在制备营养或保护脑神经的药物或特殊食品方面的应用；在制备防治神经退行性疾病的药物中的应用；在制备降低发生心肌梗死、脑卒中或心血管疾病导致的风险的药物中应用；在制备改善心肌缺血和改善脑缺血、保护心脑细胞、降血脂、防治心脑血管疾病、保护心脑血管的药物中的应用；在制备治疗脂肪肝的药物或特殊食品方面的应用；在制备减肥的药物或特殊食品方面的应用；在制备抗疲劳的药物或特殊食品方面的应用；在制备提供不饱和脂肪酸的药物或特殊食品方面的应用；或者，在制备提供脂溶性的药物或特殊食品方面的应用。In one aspect, the hydrophilic lipid composition of the present invention can provide unsaturated fatty acids beneficial to the treatment of human health and diseases, such as nervonic acid, α-linolenic acid, γ-linolenic acid, DHA, EPA, and peanuts. Oleic acid, and the like, as well as fat-soluble drugs or nutrients such as vitamin E, medium chain triglycerides, phospholipids, vitamin A, vitamin D, lutein ester, coenzyme Q10, etc.; on the other hand, the present invention is emulsified The agent and the fat-soluble substance have good pharmacological synergistic effects, and have good synergistic effects on human health, especially in oral supplementation of phospholipids, unsaturated fatty acids and fat-soluble drugs. Therefore, still further, the present invention also provides a hydrophilic lipid composition containing an emulsifier and a liquid fat through with water The base liquid is mixed, shaken to prepare an emulsion for oral drinking, and is used for preparing medicines or special foods for preventing and treating cardiovascular and cerebrovascular diseases; and for preparing medicines or special foods for nourishing or protecting cranial nerves In the preparation of drugs for preventing and treating neurodegenerative diseases; in the preparation of drugs for reducing the risk of myocardial infarction, stroke or cardiovascular disease; in the preparation of improving myocardial ischemia and improving cerebral ischemia, protecting the heart and brain Use of cells, hypolipidemic, prevention and treatment of cardiovascular and cerebrovascular diseases, drugs for protecting cardiovascular and cerebrovascular diseases; application in the preparation of drugs or special foods for treating fatty liver; application in preparation of drugs or special foods for weight loss; Use of fatigued drugs or special foods; application in the preparation of drugs or special foods that provide unsaturated fatty acids; or in the preparation of drugs or special foods that provide fat-soluble drugs.
本发明所述的亲水性脂类组合物，也可用于餐食制作中，在任何需要用水来制作或调配的各种餐食中，都可以用本发明所述的亲水性脂类组合物与水调配成的乳浊液来代替水在餐食制作中的应用，由此制作的餐食，不仅补充了人体必需的脂肪酸和液体脂肪，而且，所制作出的餐食，还有淡浓相宜的油香味，有利于提高食欲，更重要的是，餐食制作的过程，对于消费者来说，一方面，是一种乐趣，尤其是将油基物质与水基物质通过一两秒钟的振晃过程，瞬间变为乳浊液，极大地提高了消费者的饮用或进食的欲望，这种自调配饮食的过程，所产生的心理欲望有助于本发明健康营养的油基物质的摄入；另一方面，将本发明亲水性脂类组合物与水调配的过程，是一种调餐食制作者动手、动脑及用眼的过程，尤其是将油基物质与水基物质通过一两秒钟的振晃过程，瞬间变为乳浊液，极大地提高了消费者的饮用或进食的欲望，这种自调配饮食的过程，所产生的心理欲望有助于本发明健康营养的油基物质的摄入；另外，这种振晃(振动和摇晃)的过程会释放压力，这种过程带来的是一种愉悦的心情，优化了饮食情绪，这种心情愉悦的状态有助于饮食健康，不仅有助于本发明健康营养的油基物质的作用发挥，更能提高对饮料或匀浆膳的食用量，降低弃饮率，减少浪费和污染。The hydrophilic lipid composition of the present invention can also be used in the preparation of meals, and the hydrophilic lipid combination of the present invention can be used in any meal which needs to be prepared or formulated with water. The emulsion formulated with water and water replaces the application of water in the preparation of meals. The prepared food not only supplements the essential fatty acids and liquid fat, but also the prepared meals. Concentrated oily aromas help to increase appetite and, more importantly, the process of making meals, for the consumer, on the one hand, is a pleasure, especially by passing oil-based substances and water-based substances for a second or two. The vibration process of the clock instantly turns into an emulsion, which greatly enhances the consumer's desire to drink or eat. The self-producing diet process produces a psychological desire to contribute to the healthy and nutrient-based oil-based substance of the present invention. Ingestion; on the other hand, the process of formulating the hydrophilic lipid composition of the present invention with water is a process of cooking, brain-moving and using the eye, especially for oil-based substances and water-based substances. The substance oscillates through a second or two Cheng, instantly becomes an emulsion, greatly increasing the consumer's desire to drink or eat. The self-producing diet process produces a psychological desire to contribute to the healthy nutrition of the present invention; In addition, this process of vibration (vibration and shaking) releases stress. This process brings a pleasant mood and optimizes eating mood. This pleasant state helps the diet to be healthy, not only helpful. The action of the oil-based substance of the healthy nutrition of the invention can further improve the consumption of the beverage or the homogenized meal, reduce the rate of discarded beverages, and reduce waste and pollution.
本发明提供的亲水性脂类组合物，实现了油-水快速相融的产品调配方式，具有重大意义。对于饮料或匀浆膳，将油基物质与水基物质分别独立包装，并将两者的独立包装组合在一起，在使用时通过振晃调配的方式而使两者快速混合而形成乳浊液，这种方法使得油基物质与水基物质独立保存而使各自的稳定性显著提高，无需添加乳浊液稳定剂，避免了不饱和脂肪酸发生降解，极大提高了产品的稳定性、保证了质量、保持了良好的风味和口感，也延长了货架期或保质期，有利于商品的质量保证和流通。The hydrophilic lipid composition provided by the invention realizes the product blending mode of oil-water rapid blending, and has great significance. For beverage or homogenized diets, the oil-based substance and the water-based substance are separately packaged separately, and the individual packages of the two are separately combined, and the two are rapidly mixed to form an emulsion by shaking and mixing. This method allows oil-based substances to be independently stored with water-based substances, so that their respective stability is significantly improved, no need to add an emulsion stabilizer, avoiding degradation of unsaturated fatty acids, greatly improving product stability and ensuring Quality, maintain a good flavor and taste, and also extend the shelf life or shelf life, which is conducive to the quality assurance and circulation of goods.
更进一步的健康意义是，本发明提供的亲水性脂类组合物，不仅可以带给消费者更多的健康脂肪，例如中链甘油三酯、ω-3脂肪酸、ω-6脂肪酸、磷脂、花生四烯酸、维生素E、维生素A、维生素D、共轭亚油酸、植物甾醇等健康、营养、疾病防治类的物质，例如保护心脑血管、提高智力、营养神经；而且使得消费者更容易、更方便地以饮料、匀浆膳、普通餐食的方式获得这些对身体健康、疾病防治十分有益的物质。 A further health significance is that the hydrophilic lipid composition provided by the present invention can not only bring more healthy fat to consumers, such as medium chain triglycerides, omega-3 fatty acids, omega-6 fatty acids, phospholipids, Arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid, plant sterols and other health, nutrition, disease prevention and control substances, such as protecting the cardiovascular and cerebrovascular, improving intelligence, nutrition nerves; and making consumers more It is easy and convenient to obtain these substances which are very beneficial to health and disease prevention by means of beverages, homogenized meals and ordinary meals.
可以想象到，本发明提供的亲水性脂类组合物，有利于改善人们现有的饮食习惯，甚至有利于改善人类的餐食制作习惯和餐食搭配理念。It is conceivable that the hydrophilic lipid composition provided by the invention is beneficial to improving people's existing eating habits, and even beneficial to improving human meal making habits and meal matching concepts.
应当理解的,口服的制剂需要经过胃肠道的吸收才能进入人体血液以达到生理作用,口服吸收的好坏,直接影响着药物的治疗效果。按照药剂学的概念,生物利用度(Bioavailability)指制剂被吸收进入血液循环的利用程度和利用速度。It should be understood that the oral preparation needs to be absorbed by the gastrointestinal tract to enter the human blood to achieve physiological effects, and the oral absorption is directly and directly affects the therapeutic effect of the drug. According to the concept of pharmacy, Bioavailability refers to the degree of utilization and utilization rate of the preparation absorbed into the blood circulation.
相比其它非乳化液型的制剂,本发明含有乳化剂、脂溶性物质，在水基的液体中快速形成乳浊液，具有优异的水-油溶解性,对于以脂溶性物质为活性成份的口服制剂在吸收进入血液循环的程度与速度方面,具有显著的促进作用和意义,这对于脂溶性物质的生物利用度的提高具有重要意义。制剂进入胃肠后的吸收过程,分两个阶段,即分散和胃肠壁吸收两个阶段,首先需要在胃液或肠液中分散开,然后再接触并附着于胃肠壁进行吸收而进入血液,这两个阶段都会影响不饱和脂肪酸和其它健康功能的脂溶性物质的吸收利用和健康作用的发挥,将脂溶性物质制备为水分散性好的乳化液形式,脂溶性物质的溶出和分散速度显著加快,大大提高了它在胃液或肠液中分散的程度和分散速度,使脂溶性物质与胃肠壁的接触更充分,附着于胃肠壁吸收而进入血液的活性成份也更加充分,这对于脂溶性物质的生物利用度的提高具有重要意义。例如，神经酸、DHA、EPA、磷脂酰丝氨酸、中链甘油三酯、α-亚麻酸、γ-亚麻酸等经过本发明提供的亲水性脂类组合物与水基液体调配成乳浊液饮用，其生物利用度(Bioavailability)明显改善，具有非常显著作用。Compared with other non-emulsion type preparations, the present invention contains an emulsifier, a fat-soluble substance, rapidly forms an emulsion in a water-based liquid, has excellent water-oil solubility, and is active as a fat-soluble substance. Oral preparations have a significant promoting effect and significance in the extent and speed of absorption into the blood circulation, which is of great significance for the improvement of the bioavailability of fat-soluble substances. The absorption process of the preparation into the gastrointestinal tract is divided into two stages, namely, dispersion and absorption of the gastrointestinal wall. First, it needs to be dispersed in the gastric juice or intestinal fluid, and then contacted and attached to the gastrointestinal wall for absorption and into the blood. These two stages will affect the absorption and utilization of fat-soluble substances of unsaturated fatty acids and other healthy functions, and the health effects. The fat-soluble substances are prepared in the form of a water-dispersible emulsion, and the dissolution and dispersion speed of the fat-soluble substances are remarkable. Accelerate, greatly increase the degree of dispersion and dispersion speed in gastric juice or intestinal juice, make the fat-soluble substance more fully contact with the gastrointestinal wall, and adhere to the gastrointestinal wall to absorb the active ingredients into the blood, which is more sufficient. The improvement of the bioavailability of soluble substances is of great significance. For example, a hydrophilic lipid composition provided by the present invention, such as nervonic acid, DHA, EPA, phosphatidylserine, medium chain triglyceride, α-linolenic acid, γ-linolenic acid, etc., is formulated into an emulsion with a water-based liquid. Drinking, its bioavailability is significantly improved, and has a very significant effect.
本发明亲水性脂类组合物及其调配方法，解决了现有技术的诸多缺点，具有以下优点：1、油脂类成分，不含水，稳定性好；2、具有优秀的亲水性，能与水混合并分散形成乳浊液，有利于食用和便于操作；3、调配方便、快捷，通过在容器中振晃，可在1～5秒内形成均一的乳浊液，给饮食调配或制作带来愉悦的心情，有助于释放压力和饮食健康，优化饮食情绪；4、提高功能性脂肪酸或脂溶性物质的生物利用度；5、所形成的乳浊液有较好的稳定性，静置5min以上，可保持均一、稳定的乳浊液；6、所形成的乳浊液在久置发生分层后，经轻微摇晃，仍可形成均一的乳浊液，有利于使用者间断性地饮用或口服摄入。The hydrophilic lipid composition of the invention and the preparation method thereof solve many shortcomings of the prior art, and have the following advantages: 1. Oil-based components, no water, good stability; 2. Excellent hydrophilicity, energy It is mixed with water and dispersed to form an emulsion, which is convenient for consumption and easy to operate. 3. It is convenient and quick to mix. By shaking in the container, a uniform emulsion can be formed in 1 to 5 seconds to prepare or make a diet. Bring a pleasant mood, help release stress and diet, optimize eating mood; 4, improve the bioavailability of functional fatty acids or fat-soluble substances; 5, the emulsion formed has better stability, static After being placed for more than 5 minutes, a uniform and stable emulsion can be maintained. 6. After the stratification is formed for a long time, the emulsion can be formed by a slight shaking, which is beneficial to the user intermittently. Drink or take it orally.
具体实施方式 在本发明的实施过程中,本领域普通技术人员在不脱离本发明的范围和精神实质的基础上产生的各种实施方案和修饰是显而易见的并且是容易进行的。通过下面的实施例来对本发明的应用等做进一步具体说明,但并不表示实施例对本发明的限制。DETAILED DESCRIPTION OF THE INVENTION Various embodiments and modifications made by those skilled in the art without departing from the scope and spirit of the invention are obvious and The application and the like of the present invention are further illustrated by the following examples, which are not intended to limit the invention.
实施例1、亲水性的脂类组合物、其制备及调配方法、组合使用。Example 1. A hydrophilic lipid composition, a preparation and formulation method thereof, and a combination use.
亲水性的脂类组合物，处方量以重量百分比计，分别含有： A hydrophilic lipid composition, in a percentage by weight, containing:
Figure PCTCN2017101851-appb-000001
Figure PCTCN2017101851-appb-000001
其中，所述磷脂选自大豆磷脂、大豆卵磷脂、蛋黄磷脂、蛋黄卵磷脂或磷虾油。Wherein the phospholipid is selected from the group consisting of soybean phospholipids, soy lecithin, egg yolk phospholipids, egg yolk lecithin or krill oil.
其制备方法一，包括：The preparation method thereof comprises:
(1)配料：按配方称取乳化剂、液体脂肪、其它脂溶性物质，定容至所需生产量，搅拌混合、分散均匀，或者，先将其它脂溶性物质，如神经酸、DHA、花生四烯酸、植物甾醇酯或磷脂酰丝氨酸加入液体脂肪并使其完全溶解于液体脂肪，再加入乳化剂，搅拌混合、分散均匀； (1) Ingredients: Weigh emulsifier, liquid fat, other fat-soluble substances according to the formula, dilute to the required production amount, mix and mix evenly, or firstly add other fat-soluble substances such as nervonic acid, DHA, peanuts. The tetraenoic acid, phytosterol ester or phosphatidylserine is added to the liquid fat and completely dissolved in the liquid fat, and then the emulsifier is added, stirred and mixed, and uniformly dispersed;
(2)将(1)中配制好的液体置于乳化罐中，加热使液体温度为45℃以上，于搅拌转速大于500r/min的条件下，进行搅拌操作3～25min，然后在3～5min内迅速将液体冷却至25℃以下，停止搅拌，静置；或者，将(1)中配制好的液体置于乳化罐中，加热使液体温度为45℃以上，于均质机中进行压力为20～58MPa的均质，然后在3～5min内迅速将液体冷却至25℃以下，停止搅拌；(2) The liquid prepared in (1) is placed in an emulsification tank, heated to a temperature of 45 ° C or higher, and stirred at a stirring speed of more than 500 r/min for 3 to 25 minutes, and then at 3 to 5 minutes. The liquid is quickly cooled to below 25 ° C, the stirring is stopped, and the mixture is allowed to stand; or, the liquid prepared in (1) is placed in an emulsification tank, and the temperature of the liquid is 45 ° C or higher, and the pressure is performed in the homogenizer. Homogenization of 20 to 58 MPa, and then quickly cool the liquid to below 25 ° C within 3 to 5 minutes, and stop stirring;
(3)灌装：将油状液体进行真空脱气，灌装，封口，包装、检验，即得。(3) Filling: The oily liquid is vacuum degassed, filled, sealed, packaged and inspected.
或者，其制备方法二，包括：Or, the preparation method 2 thereof includes:
(1)配料：按配方称取乳化剂、液体脂肪、其它脂溶性物质，定容至所需生产量，搅拌混合、分散均匀，或者，先将其它脂溶性物质，如神经酸、DHA、花生四烯酸、植物甾醇酯或磷脂酰丝氨酸加入液体脂肪并使其完全溶解于液体脂肪，再加入乳化剂，搅拌混合、分散均匀；(1) Ingredients: Weigh emulsifier, liquid fat, other fat-soluble substances according to the formula, dilute to the required production amount, mix and mix evenly, or firstly add other fat-soluble substances such as nervonic acid, DHA, peanuts. The tetraenoic acid, phytosterol ester or phosphatidylserine is added to the liquid fat and completely dissolved in the liquid fat, and then the emulsifier is added, stirred and mixed, and uniformly dispersed;
(2)将(1)中配制好的液体置于乳化罐中，向油状液体中持续通入氮气或者保持乳化罐中的压强大于1.3大气压，并于搅拌转速大于300r/min的条件下进行搅拌操作3～25min，使油状液体呈现非透明状的富含氮气的泡沫型油脂物，停止搅拌；(2) placing the liquid prepared in (1) in an emulsification tank, continuously introducing nitrogen into the oily liquid or keeping the pressure in the emulsification tank stronger than 1.3 atm, and stirring at a stirring speed of more than 300 r/min. After operation for 3 to 25 minutes, the oily liquid is rendered as a non-transparent nitrogen-rich foam-type grease, and the stirring is stopped;
(3)灌装：将(2)中制备的油状液体灌装于容器中，进一步对容器进行充入氮气，并使容器中气体压强大于1.2大气压，密封封口，包装、检验，即得。(3) Filling: The oily liquid prepared in (2) is filled in a container, and the container is further filled with nitrogen gas, and the gas pressure in the container is stronger than 1.2 atm, sealed and sealed, packaged, and inspected.
或者，其制备方法三，包括：Or, the preparation method thereof includes:
(1)配料：按配方称取乳化剂、液体脂肪、其它脂溶性物质，待用；(1) Ingredients: Weigh emulsifier, liquid fat, other fat-soluble substances according to the formula, and use;
(2)将液体脂肪和脂溶性物质混合、搅拌，使其混合分散均匀，得到脂溶性物质的混合物，或者，先将其它脂溶性物质，如神经酸、DHA、花生四烯酸、植物甾醇酯或磷脂酰丝氨酸加入液体脂肪并使其完全溶解于液体脂肪，搅拌混合、分散均匀；(2) mixing and stirring the liquid fat and the fat-soluble substance, mixing and dispersing uniformly to obtain a mixture of fat-soluble substances, or firstly, other fat-soluble substances such as nervonic acid, DHA, arachidonic acid, phytosterol ester Or phosphatidylserine is added to the liquid fat and completely dissolved in the liquid fat, stirred and mixed uniformly;
(3)乳化剂的预混合：取乳化剂及乳化剂重量3～7倍的(2)中制备的脂溶性物质的混合物，置于乳化罐中，向油状液体中持续通入氮气或者保持乳化罐中的压强大于1.3大气压，并于搅拌转速大于300r/min的条件下搅拌，使油状液体呈现非透明状的富含氮气的泡沫型油脂物，或者油脂呈现泡沫状，停止搅拌；(3) Premixing of emulsifier: a mixture of the fat-soluble substance prepared in (2) in an amount of 3 to 7 times by weight of the emulsifier and the emulsifier, placed in an emulsification tank, continuously supplied with nitrogen into the oily liquid or kept emulsified The pressure in the tank is stronger than 1.3 atmospheres, and is stirred under the stirring speed of more than 300r/min, so that the oily liquid exhibits a non-transparent nitrogen-rich foam-type grease, or the oil is foamed, and the stirring is stopped;
(4)将(3)中配制好的乳化剂的预混合物料置于乳化罐中，加入剩余的脂溶性物质的混合物，向油状液体中持续通入氮气或者保持乳化罐中的压强大于1.3大气压，并于搅拌转速大于300r/min的条件下搅拌，使油状液体呈现非透明状的富含氮气的泡沫型油脂物，停止搅拌；(4) placing the premixed emulsifier prepared in (3) in an emulsification tank, adding a mixture of the remaining fat-soluble substances, continuously introducing nitrogen into the oily liquid or maintaining the pressure in the emulsification tank at 1.3 atmospheres. And stirring at a stirring speed of more than 300r/min, so that the oily liquid exhibits a non-transparent nitrogen-rich foam-type grease, and the stirring is stopped;
(5)灌装：将(4)中制备的油状液体灌装于容器中，进一步对容器进行充入氮气并使容器中气体压强大于1.2大气压，密封封口，包装、检验，即得。 (5) Filling: The oily liquid prepared in (4) is filled in a container, and the container is further filled with nitrogen gas and the gas pressure in the container is stronger than 1.2 atm, sealed and sealed, packaged, and inspected.
快速调配性能：将本实施例中任意一种配比的亲水性脂类组合物与水基液体倒入调配瓶中，其中水基液体与亲水性的脂类组合物的重量比大于10:1，使亲水性脂类组合物和水基液体的总体积不超过调配瓶容量的98％，拧紧调配瓶的盖子，用手或机械手将调配瓶于1秒钟内振晃至少1次的频率，使调配瓶振晃至多5秒钟，调配瓶振晃时，调配瓶每次位移的距离不小于10厘米，并且使混合液向调配瓶的剩余空间运动，优选使混合液向调配瓶的剩余空间运动并冲击调配瓶的盖子，按上述方法，即可形成均一的乳浊液，该乳浊液在室温下静置5min仍呈均一乳浊液，不发生分层；所述调配瓶，是带盖的玻璃瓶、带盖的塑料瓶、带盖的铝-塑纸盒、带盖的金属容器，例如，高分子PET瓶，高密度聚乙烯瓶瓶，等等；带盖是为了能够拧紧盖子进行振晃调配的操作，优选调配瓶的容积不大于3升，例如优选调配瓶的容积为0.5升，所述含水基液体包括水、含水量大于60％的液体，或者含有乙醇的水溶液，例如所述水基液体选自下述一种或多种物质的水溶液：蔗糖、葡萄糖、果糖、麦芽糖、壳寡糖、低聚果糖、低聚木糖、聚葡萄糖、菊粉、牛磺酸、半胱氨酸、胱氨酸、甘氨酸、天冬氨酸、天冬酰胺、谷氨酸、谷氨酰胺、赖氨酸、精氨酸、鸟氨酸、维生素C、维生素B、左旋肉碱、叶酸、烟酸、胆碱、肌醇。Rapid compounding performance: Pour any proportion of the hydrophilic lipid composition and water-based liquid in the present embodiment into a mixing bottle, wherein the weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 10 :1, so that the total volume of the hydrophilic lipid composition and the water-based liquid does not exceed 98% of the capacity of the blending bottle, tighten the lid of the blending bottle, and shake the blending bottle at least once in 1 second by hand or robot. The frequency of the bottle is shaken for up to 5 seconds. When the bottle is shaken, the distance of the bottle is not less than 10 cm per movement, and the mixture is moved to the remaining space of the bottle, preferably the mixture is dispensed. The remaining space moves and impacts the cover of the bottle, and according to the above method, a uniform emulsion can be formed. The emulsion is still in a uniform emulsion after standing at room temperature for 5 minutes, and no delamination occurs; , is a glass bottle with a lid, a plastic bottle with a lid, an aluminum-plastic paper box with a lid, a metal container with a lid, for example, a polymer PET bottle, a high-density polyethylene bottle, etc.; Capable of tightening the lid for vibrating and dispensing, preferably mixing the bottle The volume of the bottle is not more than 3 liters. For example, the volume of the bottle is preferably 0.5 liter. The aqueous base liquid includes water, a liquid having a water content of more than 60%, or an aqueous solution containing ethanol. For example, the water-based liquid is selected from the following one. Aqueous solution of one or more substances: sucrose, glucose, fructose, maltose, chitosan oligosaccharide, oligofructose, xylooligosaccharide, polydextrose, inulin, taurine, cysteine, cystine, glycine, Aspartic acid, asparagine, glutamic acid, glutamine, lysine, arginine, ornithine, vitamin C, vitamin B, L-carnitine, folic acid, niacin, choline, inositol.
实施例2、亲水性的脂类组合物、其制备及调配方法。Example 2. Hydrophilic lipid composition, preparation and formulation method thereof.
亲水性的脂类组合物，处方量以重量百分比计，分别含有：A hydrophilic lipid composition, in a percentage by weight, containing:
Figure PCTCN2017101851-appb-000002
Figure PCTCN2017101851-appb-000002
Figure PCTCN2017101851-appb-000003
Figure PCTCN2017101851-appb-000003
其中，所述磷脂选自大豆磷脂、大豆卵磷脂、蛋黄磷脂、蛋黄卵磷脂或磷虾油；α-亚麻酸的供体植物油选自亚麻籽油、紫苏籽油、南瓜籽油、牡丹籽油、杜仲籽油或美藤果油；γ-亚麻酸的供体油选自γ-亚麻酸油脂；亚油酸的供体植物油选自大豆油、玉米油、花生油、葵花籽油、橄榄油、水飞蓟籽油、南瓜籽油、长柄扁桃油、棕榈油、芝麻油、核桃仁油、菜籽油、红花籽油、葡萄籽油、盐地碱蓬籽油、小麦胚芽油、玉米胚芽油、光皮梾木果油、盐肤木果油、牡丹籽油、翅果油、御米油、番茄籽油、花椒籽油、芥菜籽油、茶属油(包括茶叶籽油、油茶籽油或茶树油)、米糠油、乳木果油、玻璃苣油、辣椒籽油、椰子油或棉籽油；油酸的供体植物油选自大豆油、玉米油、花生油、葵花籽油、橄榄油、南瓜籽油、水飞蓟籽油、长柄扁桃油、棕榈油、芝麻油、核桃仁油、菜籽油、红花籽油、葡萄籽油、米糠油、辣椒籽油、石榴籽油、鸦胆子油或椰子油中；神经酸的供体动植物油包括元宝枫籽油或鲨鱼油；DHA的供体动植物油包括DHA藻油、磷虾油、鱼油或鱼油提取物；EPA的供体动植物油包括磷虾油、鱼油或鱼油提取物。Wherein the phospholipid is selected from the group consisting of soybean phospholipid, soybean lecithin, egg yolk phospholipid, egg yolk lecithin or krill oil; the donor vegetable oil of α-linolenic acid is selected from the group consisting of linseed oil, perilla seed oil, pumpkin seed oil, and peony seed. Oil, Eucommia seed oil or Meito fruit oil; γ-linolenic acid donor oil is selected from γ-linolenic acid oil; linoleic acid donor vegetable oil is selected from soybean oil, corn oil, peanut oil, sunflower oil, olive oil , milk thistle seed oil, pumpkin seed oil, long handle almond oil, palm oil, sesame oil, walnut oil, rapeseed oil, safflower seed oil, grape seed oil, salicin seed oil, wheat germ oil, corn Germ oil, light-skinned avocado oil, salted wood fruit oil, peony seed oil, samara oil, glutinous rice oil, tomato seed oil, pepper seed oil, mustard seed oil, tea oil (including tea seed oil, Camellia seed oil or tea tree oil), rice bran oil, shea butter, borage oil, pepper seed oil, coconut oil or cottonseed oil; oleic acid donor vegetable oil is selected from the group consisting of soybean oil, corn oil, peanut oil, sunflower oil, Olive oil, pumpkin seed oil, milk thistle seed oil, long handle almond oil, palm oil, sesame oil, Peach kernel oil, rapeseed oil, safflower seed oil, grape seed oil, rice bran oil, chili seed oil, pomegranate seed oil, Brucea javanica oil or coconut oil; the supply of nerve acid animal and vegetable oil includes acerola seed oil or shark oil DHA's donor animal and vegetable oils include DHA algae oil, krill oil, fish oil or fish oil extract; EPA's donor animal and vegetable oils include krill oil, fish oil or fish oil extract.
制备方法：其制备方法与是实施例1中的制备方法一、制备方法二或制备方法三相同，实施例1中的制备方法可完全适用于本实施例。 Preparation method: The preparation method is the same as the preparation method 1, the preparation method 2 or the preparation method 3 in the first embodiment, and the preparation method in the embodiment 1 can be completely applied to the embodiment.
调配：将任意一种配比的亲水性脂类组合物用水基液体通过振晃而调配成乳浊液，优选所述水基液体选自下述一种或多种物质的水溶液：蔗糖、葡萄糖、果糖、麦芽糖、壳寡糖、低聚果糖、低聚木糖、聚葡萄糖、菊粉、牛磺酸、半胱氨酸、胱氨酸、甘氨酸、天冬氨酸、天冬酰胺、谷氨酸、谷氨酰胺、赖氨酸、精氨酸、鸟氨酸、维生素C、维生素B、左旋肉碱、叶酸、烟酸、胆碱、肌醇，或者水基液体选自动物乳液、动物蛋白粉的水乳浊液或植物蛋白粉的水乳浊液。Formulation: any one of the proportions of the hydrophilic lipid composition is formulated into an emulsion by shaking with a water-based liquid, preferably the aqueous liquid is selected from the aqueous solution of one or more of the following: sucrose, Glucose, fructose, maltose, chitosan oligosaccharide, oligofructose, xylooligosaccharide, polydextrose, inulin, taurine, cysteine, cystine, glycine, aspartic acid, asparagine, valley Acid, glutamine, lysine, arginine, ornithine, vitamin C, vitamin B, L-carnitine, folic acid, niacin, choline, inositol, or water-based liquid selected from animal lotions, animals An aqueous emulsion of protein powder or an aqueous emulsion of vegetable protein powder.
实施例3、亲水性的脂类组合物、其制备及调配方法。Example 3, a hydrophilic lipid composition, a preparation thereof, and a formulation method.
亲水性的脂类组合物，处方量以重量百分比计，分别含有：A hydrophilic lipid composition, in a percentage by weight, containing:
Figure PCTCN2017101851-appb-000004
Figure PCTCN2017101851-appb-000004
Figure PCTCN2017101851-appb-000005
Figure PCTCN2017101851-appb-000005
其中，所述磷脂包括大豆磷脂、大豆卵磷脂、蛋黄磷脂、蛋黄卵磷脂或磷虾油；亚油酸的供体植物油选自大豆油、玉米油、花生油、葵花籽油、橄榄油、水飞蓟籽油、南瓜籽油、长柄扁桃油、棕榈油、芝麻油、核桃仁油、菜籽油、红花籽油、葡萄籽油、盐地碱蓬籽油、小麦胚芽油、玉米胚芽油、光皮梾木果油、盐肤木果油、牡丹籽油、翅果油、御米油、番茄籽油、花椒籽油、芥菜籽油、茶属油(包括茶叶籽油、油茶籽油或茶树油)、米糠油、辣椒籽油、石榴籽油、鸦胆子油或椰子油；油酸的供体植物油选自大豆油、玉米油、花生油、葵花籽油、橄榄油、南瓜籽油、水飞蓟籽油、长柄扁桃油、棕榈油、芝麻油、核桃仁油、菜籽油、红花籽油、葡萄籽油、米糠油、辣椒籽油或椰子油。Wherein the phospholipid comprises soybean phospholipid, soybean lecithin, egg yolk phospholipid, egg yolk lecithin or krill oil; the donor vegetable oil of linoleic acid is selected from the group consisting of soybean oil, corn oil, peanut oil, sunflower oil, olive oil, water fly Quail seed oil, pumpkin seed oil, long handle almond oil, palm oil, sesame oil, walnut kernel oil, rapeseed oil, safflower seed oil, grape seed oil, salicin seed oil, wheat germ oil, corn germ oil, Light-skinned avocado oil, salted wood fruit oil, peony seed oil, samara oil, glutinous rice oil, tomato seed oil, pepper seed oil, mustard seed oil, tea oil (including tea seed oil, camellia seed oil) Or tea tree oil), rice bran oil, chili seed oil, pomegranate seed oil, Brucea javanica oil or coconut oil; oleic acid donor vegetable oil is selected from the group consisting of soybean oil, corn oil, peanut oil, sunflower oil, olive oil, pumpkin seed oil, Milk thistle seed oil, long handle almond oil, palm oil, sesame oil, walnut kernel oil, rapeseed oil, safflower seed oil, grape seed oil, rice bran oil, chili seed oil or coconut oil.
制备方法：其制备方法与是实施例1中的制备方法一、制备方法二或制备方法三相同，实施例1中的制备方法可完全适用于本实施例。Preparation method: The preparation method is the same as the preparation method 1, the preparation method 2 or the preparation method 3 in the first embodiment, and the preparation method in the embodiment 1 can be completely applied to the embodiment.
调配：将任意一种配比的亲水性脂类组合物用水基液体通过振晃而调配成乳浊液，例如优选水基液体选自下述一种或多种物质的水溶液：蔗糖、葡萄糖、果糖、麦芽糖、壳寡糖、低聚果糖、低聚木糖、聚葡萄糖、菊粉、牛磺酸、半胱氨酸、胱氨酸、甘氨酸、天冬氨酸、天冬酰胺、谷氨酸、谷氨酰胺、赖氨酸、精氨酸、鸟氨酸、维生素C、维生素B、左旋肉碱、叶酸、烟酸、胆碱、肌醇，或者水基液体选自动物乳液、动物蛋白粉的水乳浊液或植物蛋白粉的水乳浊液。Formulation: any one of the proportions of the hydrophilic lipid composition is formulated into an emulsion by shaking with a water-based liquid. For example, it is preferred that the water-based liquid is selected from an aqueous solution of one or more of the following: sucrose, glucose , fructose, maltose, chitosan oligosaccharide, oligofructose, xylooligosaccharide, polydextrose, inulin, taurine, cysteine, cystine, glycine, aspartic acid, asparagine, glutamine Acid, glutamine, lysine, arginine, ornithine, vitamin C, vitamin B, L-carnitine, folic acid, niacin, choline, inositol, or water-based liquid selected from animal lotion, animal protein An aqueous emulsion of powdered water or vegetable protein powder.
实施例4、亲水性的脂类组合物、其制备及调配方法。Example 4, a hydrophilic lipid composition, a preparation thereof, and a formulation method.
亲水性的脂类组合物，处方量以重量百分比计，分别含有：A hydrophilic lipid composition, in a percentage by weight, containing:
Figure PCTCN2017101851-appb-000006
Figure PCTCN2017101851-appb-000006
Figure PCTCN2017101851-appb-000007
Figure PCTCN2017101851-appb-000007
其中，所述磷脂选自大豆磷脂、大豆卵磷脂、蛋黄磷脂、蛋黄卵磷脂或磷虾油；α-亚麻酸的供体植物油包括亚麻籽油、紫苏籽油、南瓜籽油、牡丹籽油、杜仲籽油或美藤果油；γ-亚麻酸的供体油选自γ-亚麻酸油脂；亚油酸的供体植物油选自大豆油、玉米油、花生油、葵花籽油、橄榄油、水飞蓟籽油、南瓜籽油、长柄扁桃油、棕榈油、芝麻油、核桃仁油、菜籽油、红花籽油、葡萄籽油、盐地碱蓬籽油、小麦胚芽油、玉米胚芽油、光皮梾木果油、盐肤木果油、牡丹籽油、翅果油、御米油、番茄籽油、花椒籽油、芥菜籽油、茶属油(包括茶叶籽油、油茶籽油或茶树油)、米糠油、辣椒籽油、石榴籽油、鸦胆子油或椰子油；油酸的供体植物油选自大豆油、玉米油、花生油、葵花籽油、橄榄油、南瓜籽油、水飞蓟籽油、长柄扁桃油、棕榈油、芝麻油、核桃仁油、菜籽油、红花籽油、葡萄籽油、米糠油、辣椒籽油或椰子油。Wherein the phospholipid is selected from the group consisting of soybean phospholipid, soybean lecithin, egg yolk phospholipid, egg yolk lecithin or krill oil; the donor vegetable oil of α-linolenic acid comprises linseed oil, perilla seed oil, pumpkin seed oil, peony seed oil , Eucommia seed oil or Meito fruit oil; γ-linolenic acid donor oil is selected from γ-linolenic acid oil; linoleic acid donor vegetable oil is selected from soybean oil, corn oil, peanut oil, sunflower oil, olive oil, Milk thistle seed oil, pumpkin seed oil, long handle almond oil, palm oil, sesame oil, walnut oil, rapeseed oil, safflower seed oil, grape seed oil, salicin seed oil, wheat germ oil, corn germ Oil, light-skinned avocado oil, salted wood fruit oil, peony seed oil, samara oil, glutinous rice oil, tomato seed oil, pepper seed oil, mustard seed oil, tea oil (including tea seed oil, oil tea) Seed oil or tea tree oil), rice bran oil, chili seed oil, pomegranate seed oil, Brucea javanica oil or coconut oil; oleic acid donor vegetable oil is selected from soybean oil, corn oil, peanut oil, sunflower oil, olive oil, pumpkin seeds Oil, milk thistle seed oil, long handle almond oil, palm oil, sesame oil, walnut oil Rapeseed oil, safflower seed oil, grape seed oil, rice bran oil, chili oil or coconut oil.
制备方法：其制备方法与是实施例1中的制备方法一、制备方法二或制备方法三相同，实施例1中的制备方法可完全适用于本实施例。Preparation method: The preparation method is the same as the preparation method 1, the preparation method 2 or the preparation method 3 in the first embodiment, and the preparation method in the embodiment 1 can be completely applied to the embodiment.
调配：将任意一种配比的亲水性脂类组合物用水基液体通过振晃而调配成乳浊液，例如优选水基液体选自下述一种或多种物质的水溶液：蔗糖、葡萄糖、果糖、麦芽糖、壳寡糖、低聚果糖、低聚木糖、聚葡萄糖、菊粉、牛磺酸、半胱氨酸、胱氨酸、甘氨酸、天冬氨酸、天冬酰胺、谷氨酸、谷氨酰胺、赖氨酸、精氨酸、鸟氨酸、维生素C、维生素B、左旋肉碱、叶酸、烟酸、胆碱、肌醇，或者水基液体选自动物乳液、动物蛋白粉的水乳浊液或植物蛋白粉的水乳浊液。Formulation: any one of the proportions of the hydrophilic lipid composition is formulated into an emulsion by shaking with a water-based liquid. For example, it is preferred that the water-based liquid is selected from an aqueous solution of one or more of the following: sucrose, glucose , fructose, maltose, chitosan oligosaccharide, oligofructose, xylooligosaccharide, polydextrose, inulin, taurine, cysteine, cystine, glycine, aspartic acid, asparagine, glutamine Acid, glutamine, lysine, arginine, ornithine, vitamin C, vitamin B, L-carnitine, folic acid, niacin, choline, inositol, or water-based liquid selected from animal lotion, animal protein An aqueous emulsion of powdered water or vegetable protein powder.
实施例5、实施例2至实施例4的亲水性的脂类组合物快速调配性能及包装组合。 The rapid formulation performance and packaging combination of the hydrophilic lipid compositions of Example 5 and Examples 2 to 4.
取实施例2至实施例4中任意一种配比的亲水性的脂类组合物，具有良好的快速调配性能。快速调配性能：将实施例中任意一种配比的亲水性脂类组合物与水基液体倒入调配瓶中，其中水基液体与亲水性的脂类组合物的重量比大于3:1，优选水基液体与亲水性的脂类组合物的重量比大于10:1，使亲水性脂类组合物和水基液体的总体积不超过调配瓶容量的50％，拧紧调配瓶的盖子，用手或机械手将调配瓶于1秒钟内振晃至少1次的频率，使调配瓶振晃至多5秒钟，调配瓶振晃时，调配瓶每次位移的距离不小于10厘米，并且使混合液向调配瓶的剩余空间运动，优选使混合液向调配瓶的剩余空间运动并冲击调配瓶的盖子，按上述方法，即可形成均一的乳浊液，该乳浊液在室温下静置5min仍呈均一乳浊液，不发生分层；所述调配瓶，是带盖的玻璃瓶、带盖的塑料瓶、带盖的铝-塑纸盒、带盖的金属容器，例如，高分子PET瓶，高密度聚乙烯瓶瓶，等等；带盖是为了能够拧紧盖子进行振晃调配的操作，优选调配瓶的容积不大于3升，例如优选调配瓶的容积为0.5升，所述含水基液体包括水、含水量大于60％的液体，或者含有乙醇的水溶液，例如包括但不限于动物乳液、果汁、果蔬饮料、植物提取液或饮料、碳水化合物溶液或饮料、植物蛋白饮料、动物乳粉的水乳液、氨基酸的水溶液，等等。The hydrophilic lipid composition of any one of Examples 2 to 4 was obtained, and had a good rapid formulation property. Rapid formulation performance: Pour any proportion of the hydrophilic lipid composition of the embodiment with a water-based liquid into the mixing bottle, wherein the weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 3: 1. Preferably, the weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 10:1, so that the total volume of the hydrophilic lipid composition and the water-based liquid does not exceed 50% of the capacity of the blending bottle, and the mixing bottle is tightened. Cover, use the hand or robot to shake the bottle at least once in 1 second, so that the bottle shakes for up to 5 seconds. When the bottle is shaken, the distance of the bottle is not less than 10 cm. And moving the mixture to the remaining space of the blending bottle, preferably moving the mixture to the remaining space of the blending bottle and impacting the cap of the blending bottle, as described above, to form a uniform emulsion, the emulsion at room temperature After standing for 5 minutes, it still shows a uniform emulsion without delamination; the matching bottle is a glass bottle with a lid, a plastic bottle with a lid, an aluminum-plastic paper box with a lid, a metal container with a lid, for example , polymer PET bottles, high density polyethylene bottles, etc.; with cover is In order to be able to tighten the lid for the operation of the shaking arrangement, it is preferred that the volume of the blending bottle is not more than 3 liters, for example, preferably the volume of the blending bottle is 0.5 liter, the aqueous-based liquid comprises water, a liquid having a water content of more than 60%, or contains ethanol. Aqueous solutions, for example, but not limited to, animal emulsions, fruit juices, fruit and vegetable beverages, plant extracts or beverages, carbohydrate solutions or beverages, vegetable protein beverages, aqueous emulsions of animal milk powder, aqueous solutions of amino acids, and the like.
包装组合：一种包装组合物，包括将实施例中任意一种配比的亲水性脂类组合物独立包装，并与调配瓶同时存在于同一个包装盒或同一个包装袋中，所述调配瓶是带有盖子的空瓶；或者，所述调配瓶中预先装有一定体积的水基液体，用来将脂肪酸组合物直接加入调配瓶，通过振晃而形成均一的乳浊液；或者所述包装组合物中，亲水性脂类组合物的独立包装与调配瓶是同时存在于一个包装盒或包装袋中，也可以是通过粘贴固定、标签固定的方式形成组合包装，也可以是装有亲水性脂类组合物的包装瓶或包装袋与调配瓶以包装套件的形式固定在一起，或者所述包装组合物中含有本实施例中任意一种配比的亲水性脂类组合物，并且其标签上体现有将亲水性脂类组合物与水基液体通过振晃而得到乳浊液的内容。其中所述水基液体与亲水性脂类组合物的体积总和不大于容纳水基液体的容器容量或调配瓶容量的98％。Packing combination: a packaging composition comprising independently packaging a hydrophilic lipid composition of any one of the embodiments and presenting in the same package or the same package simultaneously with the dispensing bottle, The dispensing bottle is an empty bottle with a lid; or the conditioning bottle is pre-loaded with a volume of water-based liquid for directly adding the fatty acid composition to the mixing bottle to form a uniform emulsion by shaking; or In the packaging composition, the independent packaging and the blending bottle of the hydrophilic lipid composition are simultaneously present in one package or the packaging bag, or may be formed by sticking and fixing, and the label is fixed, or may be The packaging bottle or the packaging bag containing the hydrophilic lipid composition is fixed together with the dispensing bottle in the form of a packaging kit, or the packaging composition contains the hydrophilic lipid of any one of the ratios in the embodiment. The composition, and the labeling body thereof, has a content obtained by shaking a hydrophilic lipid composition and a water-based liquid to obtain an emulsion. Wherein the sum of the volume of the water-based liquid and the hydrophilic lipid composition is not more than 98% of the capacity of the container containing the water-based liquid or the capacity of the blended bottle.
包装组合：将实施例中任意一种配比的亲水性脂类组合物独立密封于容器的盖构件的腔室中，将水基液体密封于容器中，并将容器的盖构件安装在容器的开口处对容器进行密封，使得脂类组合物与水基液体各自独立密封，在使用时，将容器的盖构件打开，释放出盖构件中的脂类组合物，与容器中的水基液体混合，进一步，通过振晃而形成均一的乳浊液；Packing combination: The hydrophilic lipid composition of any one of the examples is separately sealed in the chamber of the lid member of the container, the water-based liquid is sealed in the container, and the lid member of the container is mounted on the container The container is sealed at the opening so that the lipid composition and the water-based liquid are each independently sealed. When in use, the lid member of the container is opened to release the lipid composition in the lid member, and the water-based liquid in the container Mixing, further, forming a uniform emulsion by shaking;
或者，将容器的盖构件的腔室中的脂类组合物以直径为0.4mm～2mm的液柱形式射入水基液体中，例如通过容器的盖构件的腔室中的高压气体将脂类组合物喷射出来，或者通过活塞加压、推注的方式将脂类组合物喷射出来，使脂类组合物与水基液体混合、振晃而形成乳浊液，所述水基液体包括水、含水量大于60％的液体，或者含有乙醇的水溶液。其中所述水基液体与亲水性脂类组合物的体积总和不大于容纳水基液体的容器容量的98％。 Alternatively, the lipid composition in the chamber of the lid member of the container is injected into the water-based liquid in the form of a liquid column having a diameter of 0.4 mm to 2 mm, for example, by a high-pressure gas in a chamber of the lid member of the container. The composition is sprayed out, or the lipid composition is sprayed by means of piston pressurization or bolus injection, and the lipid composition is mixed with a water-based liquid and shaken to form an emulsion, the water-based liquid including water, A liquid having a water content of more than 60% or an aqueous solution containing ethanol. Wherein the sum of the volume of the water-based liquid and the hydrophilic lipid composition is not more than 98% of the capacity of the container containing the water-based liquid.
实施例6、实施例1～4中任何一种配比的亲水性脂类组合物，取1克亲水性脂类组合物，加入2～150毫升的水基液体，经振晃，5秒钟内，甚至1秒钟内即可形成乳浊液，并且，形成的乳浊液在室温静置5min以上，能保持稳定存在，可保持均一、稳定，不发生分层现象；In Example 6, the hydrophilic lipid composition of any one of Examples 1 to 4, 1 g of the hydrophilic lipid composition was added, and 2 to 150 ml of the water-based liquid was added, and the mixture was shaken, 5 In the second, even within 1 second, the emulsion can be formed, and the formed emulsion can be kept stable at room temperature for more than 5 minutes, and can be kept stable, and can be kept uniform and stable without delamination;
或者，将亲水性脂类组合物与水基液体倒入调配瓶中，其中水或含水量大于60％的水基液体与亲水性的脂类组合物的重量比大于3:1，优选水基液体与亲水性的脂类组合物的重量比大于10:1，使亲水性脂类组合物和水基液体的总体积不超过调配瓶容量的70％，拧紧调配瓶的盖子，用手或机械手将调配瓶于1秒钟内振晃至少2次的频率，使调配瓶振晃至多5秒钟，调配瓶振晃时，调配瓶每次位移的距离不小于10厘米，并且使混合液向调配瓶的剩余空间运动，优选使混合液向调配瓶的剩余空间运动并冲击调配瓶的盖子，按上述方法，即可形成均一的乳浊液，该乳浊液在室温下静置5min仍呈均一乳浊液，不发生分层；所述调配瓶，可以是带盖的玻璃瓶、带盖的塑料瓶、带盖的铝-塑纸盒、带盖的金属容器。Alternatively, the hydrophilic lipid composition and the water-based liquid are poured into a mixing bottle, wherein the weight ratio of the water-based liquid having a water content of more than 60% to the hydrophilic lipid composition is greater than 3:1, preferably The weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 10:1, so that the total volume of the hydrophilic lipid composition and the water-based liquid does not exceed 70% of the capacity of the blending bottle, and the lid of the blending bottle is tightened. Use the hand or robot to shake the mixing bottle at least 2 times in 1 second to shake the mixing bottle for up to 5 seconds. When the bottle is shaken, the distance of the mixing bottle is not less than 10 cm each time, and The mixed liquid moves to the remaining space of the mixing bottle, preferably, the mixed liquid is moved to the remaining space of the mixing bottle and impacts the cover of the mixing bottle, and a uniform emulsion is formed according to the above method, and the emulsion is allowed to stand at room temperature. The emulsion is still uniform in 5 minutes, and no stratification occurs; the mixing bottle can be a glass bottle with a lid, a plastic bottle with a lid, an aluminum-plastic paper box with a lid, and a metal container with a lid.
实施例7、实施例1～4中任何一种配比的含有乳化剂和液体脂肪的亲水性脂类组合物通过与水基液体混合，并进一步经振晃而调配成乳浊液，在制备或调配药物、特殊医学用途配方食品、保健食品、营养食品或化妆品方面的应用，供使用者的即时调配、即时使用。 The hydrophilic lipid composition containing the emulsifier and the liquid fat of any of the examples 7 and 4 to 4 is prepared by mixing with a water-based liquid and further shaking to form an emulsion. Preparation or formulation of pharmaceuticals, special medical formulas, health foods, nutraceuticals or cosmetics for immediate deployment and immediate use by users.

Claims (24)

  1. 一种包装组合物，包括将亲水性脂类组合物与水基液体分别独立包装并组合在一起，所述亲水性脂类组合物含有液体脂肪和乳化剂，其中液体脂肪选自下述一种或多种物质：中链甘油三酯、α-亚麻酸、γ-亚麻酸、甘油二酯、油酸、亚油酸、中长链脂肪酸，液体脂肪在亲水性脂类组合物中的含量以重量比计大于45％；A packaging composition comprising separately packaging and combining a hydrophilic lipid composition and a water-based liquid, the hydrophilic lipid composition comprising a liquid fat and an emulsifier, wherein the liquid fat is selected from the group consisting of One or more substances: medium chain triglyceride, α-linolenic acid, γ-linolenic acid, diglyceride, oleic acid, linoleic acid, medium and long-chain fatty acid, liquid fat in hydrophilic lipid composition The content is greater than 45% by weight;
    乳化剂选自下述一种或多种物质：磷脂、蔗糖脂肪酸酯、单，双甘油脂肪酸酯、聚甘油脂肪酸酯、丙二醇脂肪酸酯、乳酸脂肪酸甘油酯、吐温20、吐温40、吐温60、吐温80、司盘20、司盘40、司盘60、司盘65、司盘80，乳化剂在亲水性脂类组合物中的含量以重量比计为0.05％～8％；The emulsifier is selected from one or more of the following: phospholipids, sucrose fatty acid esters, mono-, diglycerin fatty acid esters, polyglycerol fatty acid esters, propylene glycol fatty acid esters, lactic acid fatty acid glycerides, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80, the content of emulsifier in the hydrophilic lipid composition is 0.05% by weight. ~8%;
    所述水基液体，选自水、含水量大于60％的液体，或者含有乙醇的水溶液；The water-based liquid is selected from the group consisting of water, a liquid having a water content of more than 60%, or an aqueous solution containing ethanol;
    所述水基液体与亲水性脂类组合物的重量比大于3:1；The weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 3:1;
    所述水基液体与亲水性脂类组合物的体积总和不大于容纳水基液体的容器容量的98％。The sum of the volume of the water-based liquid and the hydrophilic lipid composition is not more than 98% of the capacity of the container containing the water-based liquid.
  2. 根据权利要求1所述的包装组合物，所述液体脂肪选自中链甘油三酯和下述一种或多种物质：油酸、亚油酸、亚麻酸、甘油二酯、中长链脂肪酸，其中中链甘油三酯在亲水性脂类组合物中的含量以重量比计为30％～99％。The packaging composition according to claim 1, wherein the liquid fat is selected from the group consisting of medium chain triglycerides and one or more of the following: oleic acid, linoleic acid, linolenic acid, diglyceride, medium and long chain fatty acid. Wherein the medium chain triglyceride is contained in the hydrophilic lipid composition in an amount of from 30% to 99% by weight.
  3. 根据权利要求1所述的包装组合物，所述乳化剂选自磷脂和下述一种或多种物质：蔗糖脂肪酸酯、单，双甘油脂肪酸酯、聚甘油脂肪酸酯、丙二醇脂肪酸酯、乳酸脂肪酸甘油酯、吐温20、吐温40、吐温60、吐温80、司盘20、司盘40、司盘60、司盘65、司盘80，其中乳化剂在亲水性脂类组合物中的含量以重量比计为0.1％～4％。The packaging composition according to claim 1, wherein the emulsifier is selected from the group consisting of phospholipids and one or more of the following: sucrose fatty acid esters, mono-, diglycerin fatty acid esters, polyglycerol fatty acid esters, propylene glycol fatty acids Ester, lactic acid fatty acid glyceride, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80, in which the emulsifier is hydrophilic The content in the lipid composition is from 0.1% to 4% by weight.
  4. 根据权利要求1所述的包装组合物，所述磷脂中的卵磷脂的含量大于40％。The packaging composition of claim 1 wherein the lecithin is present in the phospholipid in an amount greater than 40%.
  5. 根据权利要求1所述的包装组合物，所述水基液体选自下述一种或多种物质的水溶液：蔗糖、葡萄糖、果糖、麦芽糖、壳寡糖、低聚果糖、低聚木糖、聚葡萄糖、菊粉、牛磺酸、半胱氨酸、胱氨酸、甘氨酸、天冬氨酸、天冬酰胺、谷氨酸、谷氨酰胺、赖氨酸、精氨酸、鸟氨酸、维生素C、维生素B、左旋肉碱、叶酸、烟酸、胆碱、肌醇。The packaging composition according to claim 1, wherein the water-based liquid is selected from the group consisting of an aqueous solution of one or more of the following: sucrose, glucose, fructose, maltose, chitooligosaccharide, oligofructose, xylooligosaccharide, Polydextrose, inulin, taurine, cysteine, cystine, glycine, aspartic acid, asparagine, glutamic acid, glutamine, lysine, arginine, ornithine, Vitamin C, vitamin B, L-carnitine, folic acid, niacin, choline, inositol.
  6. 根据权利要求1所述的包装组合物，所述水基液体选自动物乳液、动物蛋白粉的水乳浊液或植物蛋白粉的水乳浊液。The packaging composition according to claim 1, wherein the water-based liquid is selected from the group consisting of an animal emulsion, an aqueous emulsion of animal protein powder, or an aqueous emulsion of vegetable protein powder.
  7. 根据权利要求1所述的包装组合物，所述亲水性脂类组合物中进一步含有脂溶性物质B，所述脂溶性物质B选自下述一种或多种物质：神经酸、DHA、EPA、花生四烯酸、维生素E、维生素A、维生素D、共轭亚油酸、共轭亚油酸甘油酯、磷脂酰丝氨酸、植物甾醇、植物甾醇酯、植物甾烷醇酯、米糠脂肪烷醇、多烯磷脂酰胆碱，其中脂溶性物质B在亲水性脂类组合物中的含量以重量比计为0.01％～30％。 The packaging composition according to claim 1, wherein the hydrophilic lipid composition further contains a fat-soluble substance B selected from one or more of the following: nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol ester, plant stanol ester, rice bran fat The alcohol, polyene phosphatidylcholine, wherein the content of the fat-soluble substance B in the hydrophilic lipid composition is 0.01% to 30% by weight.
  8. 根据权利要求1所述的包装组合物，所述亲水性脂类组合物采用以下方法制备：它包括：The packaging composition according to claim 1, wherein the hydrophilic lipid composition is prepared by the following method: it comprises:
    (1)配料：按配方称取乳化剂、液体脂肪和其它脂溶性物质，定容至所需生产量，搅拌混合、分散均匀；(1) Ingredients: Weigh emulsifier, liquid fat and other fat-soluble substances according to the formula, and make up to the required production amount, stir and mix, and disperse evenly;
    (2)将(1)中配制好的液体置于乳化罐中，加热使液体温度为45℃以上，于搅拌转速大于500r/min的条件下，进行搅拌操作3～25min，然后在3～5min内迅速将液体冷却至25℃以下，停止搅拌，静置；或者，将(1)中配制好的液体置于乳化罐中，加热使液体温度为45℃以上，于均质机中进行压力为20～58MPa的均质，然后在3～5min内迅速将液体冷却至25℃以下，停止搅拌；(2) The liquid prepared in (1) is placed in an emulsification tank, heated to a temperature of 45 ° C or higher, and stirred at a stirring speed of more than 500 r/min for 3 to 25 minutes, and then at 3 to 5 minutes. The liquid is quickly cooled to below 25 ° C, the stirring is stopped, and the mixture is allowed to stand; or, the liquid prepared in (1) is placed in an emulsification tank, and the temperature of the liquid is 45 ° C or higher, and the pressure is performed in the homogenizer. Homogenization of 20 to 58 MPa, and then quickly cool the liquid to below 25 ° C within 3 to 5 minutes, and stop stirring;
    (3)灌装：将油状液体进行真空脱气，灌装，封口，包装、检验，即得。(3) Filling: The oily liquid is vacuum degassed, filled, sealed, packaged and inspected.
  9. 根据权利要求1所述的包装组合物，所述亲水性脂类组合物采用以下方法制备：它包括：The packaging composition according to claim 1, wherein the hydrophilic lipid composition is prepared by the following method: it comprises:
    (1)配料：按配方称取乳化剂、液体脂肪和其它脂溶性物质，定容至所需生产量，搅拌混合、分散均匀；(1) Ingredients: Weigh emulsifier, liquid fat and other fat-soluble substances according to the formula, and make up to the required production amount, stir and mix, and disperse evenly;
    (2)将(1)中配制好的液体置于乳化罐中，向油状液体中持续通入氮气或者保持乳化罐中的压强大于1.3大气压，并于搅拌转速大于300r/min的条件下进行搅拌操作3～25min，使油状液体呈现非透明状的富含氮气的泡沫型的油状液体，停止搅拌；(2) placing the liquid prepared in (1) in an emulsification tank, continuously introducing nitrogen into the oily liquid or keeping the pressure in the emulsification tank stronger than 1.3 atm, and stirring at a stirring speed of more than 300 r/min. After operation for 3 to 25 minutes, the oily liquid is rendered as a non-transparent nitrogen-rich foam-like oily liquid, and the stirring is stopped;
    (3)灌装：将(2)中制备的油状液体灌装于容器中，进一步对容器进行充入氮气，并使容器中气体压强大于1.2大气压，密封封口，包装、检验，即得。(3) Filling: The oily liquid prepared in (2) is filled in a container, and the container is further filled with nitrogen gas, and the gas pressure in the container is stronger than 1.2 atm, sealed and sealed, packaged, and inspected.
  10. 权利要求1所述的包装组合物中亲水性脂类组合物与水基液体调配成乳浊液的方法，包括：将亲水性脂类组合物倒入容纳有水基液体的容器中，使亲水性脂类组合物和水基液体的总体积不超过容器容量的98％，拧紧容器的盖子，用手或机械手将调配瓶于1秒钟内振晃至少1次的频率，使容器振晃不超过10秒钟，容器振晃时，容器每次位移的距离不小于10厘米，并且使混合液向容器的剩余空间运动并冲击调配瓶的盖子而形成乳浊液；A method of formulating a hydrophilic lipid composition and a water-based liquid into an emulsion in the packaging composition according to claim 1, comprising: pouring a hydrophilic lipid composition into a container containing a water-based liquid, The total volume of the hydrophilic lipid composition and the water-based liquid is not more than 98% of the container capacity, and the lid of the container is tightened, and the mixing bottle is shaken at least once in one second by hand or a robot to make the container Shake for no more than 10 seconds, when the container is shaken, the container is displaced by a distance of not less than 10 cm each time, and the mixture is moved to the remaining space of the container and impacts the cover of the bottle to form an emulsion;
    所述水基液体的容器，选自带盖的玻璃瓶、带盖的塑料瓶、带盖的铝-塑纸盒、带盖的金属容器，并且容器的容积不大于3升。The water-based liquid container is selected from the group consisting of a glass bottle with a lid, a plastic bottle with a lid, an aluminum-plastic paper box with a lid, a metal container with a lid, and a container having a volume of no more than 3 liters.
  11. 一种含有液体脂肪和乳化剂的亲水性脂类组合物与水基液体调配成乳浊液的方法，包括：将亲水性脂类组合物与水基液体倒入调配瓶中，其中水基液体与亲水性脂类组合物的重量比大于3:1，使亲水性脂类组合物和水基液体的总体积不超过调配瓶容量的98％，拧紧调配瓶的盖子，用手或机械手将调配瓶于1秒钟内振晃至少1次的频率，使调配瓶振晃不超过10秒钟，调配瓶振晃时，调配瓶每次位移的距离不小于10厘米，并且使混合液向调配瓶的剩余空间运动而形成乳浊液；A method for formulating a hydrophilic lipid composition containing a liquid fat and an emulsifier and a water-based liquid into an emulsion, comprising: pouring a hydrophilic lipid composition and a water-based liquid into a mixing bottle, wherein the water The weight ratio of the base liquid to the hydrophilic lipid composition is greater than 3:1, so that the total volume of the hydrophilic lipid composition and the water-based liquid does not exceed 98% of the capacity of the blending bottle, and the lid of the blending bottle is tightened by hand. Or the robot will stir the bottle to vibrate at least once in 1 second, so that the bottle is shaken for no more than 10 seconds. When the bottle is shaken, the bottle is displaced by a distance of not less than 10 cm and mixed. The liquid moves to the remaining space of the mixing bottle to form an emulsion;
    所述乳化剂，选自下述一种或多种物质：磷脂、蔗糖脂肪酸酯、单，双甘油脂肪酸酯、聚 甘油脂肪酸酯、丙二醇脂肪酸酯、乳酸脂肪酸甘油酯、吐温20、吐温40、吐温60、吐温80、司盘20、司盘40、司盘60、司盘65、司盘80；The emulsifier is selected from one or more of the following: phospholipids, sucrose fatty acid esters, mono-, diglycerin fatty acid esters, poly Glycerol fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty acid glyceride, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80 ;
    所述液体脂肪，选自下述一种或多种物质：油酸、亚油酸、α-亚麻酸、γ-亚麻酸、中链甘油三酯、甘油二酯、中长链脂肪酸；The liquid fat is selected from one or more of the following: oleic acid, linoleic acid, α-linolenic acid, γ-linolenic acid, medium chain triglyceride, diglyceride, medium long chain fatty acid;
    所述水基液体，选自水、含水量大于60％的液体，或者含有乙醇的水溶液；The water-based liquid is selected from the group consisting of water, a liquid having a water content of more than 60%, or an aqueous solution containing ethanol;
    所述调配瓶，选自带盖的玻璃瓶、带盖的塑料瓶、带盖的铝-塑纸盒、带盖的金属容器，并且调配瓶的容积不大于3升。The dispensing bottle is selected from the group consisting of a glass bottle with a lid, a plastic bottle with a lid, an aluminum-plastic paper box with a lid, a metal container with a lid, and a volume of the bottle of no more than 3 liters.
  12. 根据权利要求11所述的亲水性脂类组合物与水基液体调配成乳浊液的方法，所述水基液体与亲水性脂类组合物的重量比大于10:1。The method of formulating a hydrophilic lipid composition according to claim 11 and a water-based liquid into an emulsion, wherein the weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 10:1.
  13. 根据权利要求11所述的亲水性脂类组合物与水基液体调配成乳浊液的方法，所述调配瓶振晃时间不超过5秒钟。The method of formulating a hydrophilic lipid composition according to claim 11 and a water-based liquid into an emulsion, wherein the conditioning bottle has a shaking time of not more than 5 seconds.
  14. 根据权利要求11所述的亲水性脂类组合物与水基液体调配成乳浊液的方法，所述调配瓶振晃时，使混合液向调配瓶的剩余空间运动并冲击调配瓶的盖子。The method of formulating a hydrophilic lipid composition according to claim 11 and a water-based liquid into an emulsion, wherein when the mixing bottle is shaken, the mixed liquid is moved to the remaining space of the blending bottle and impacts the cap of the blending bottle. .
  15. 根据权利要求11所述的亲水性脂类组合物与水基液体调配成乳浊液的方法，所述乳化剂在亲水性脂类组合物中的含量以重量比计为0.05％～8％，所述液体脂肪在亲水性脂类组合物中的含量以重量比计大于45％。The method for formulating a hydrophilic lipid composition according to claim 11 and an aqueous liquid into an emulsion, wherein the content of the emulsifier in the hydrophilic lipid composition is 0.05% to 8 by weight. %, the content of the liquid fat in the hydrophilic lipid composition is more than 45% by weight.
  16. 根据权利要求11所述的亲水性脂类组合物与水基液体调配成乳浊液的方法，所述亲水性脂类组合物中进一步含有脂溶性物质B，所述脂溶性物质B选自下述一种或多种物质：神经酸、DHA、EPA、花生四烯酸、维生素E、维生素A、维生素D、共轭亚油酸、共轭亚油酸甘油酯、磷脂酰丝氨酸、植物甾醇、植物甾醇酯、植物甾烷醇酯、米糠脂肪烷醇、多烯磷脂酰胆碱，其中脂溶性物质B在亲水性脂类组合物中的含量以重量比计为0.01％～30％。The method of formulating a hydrophilic lipid composition according to claim 11 and a water-based liquid into an emulsion, wherein the hydrophilic lipid composition further comprises a fat-soluble substance B, and the fat-soluble substance B is selected From one or more of the following: nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, plant Sterol, phytosterol ester, plant stanol ester, rice bran fatty alkanol, polyene phosphatidylcholine, wherein the content of fat-soluble substance B in the hydrophilic lipid composition is 0.01% to 30% by weight. .
  17. 根据权利要求11所述的亲水性脂类组合物与水基液体调配成乳浊液的方法，所述液体脂肪选自中链甘油三酯和下述一种或多种物质：油酸、亚油酸、亚麻酸、甘油二酯、中长链脂肪酸，其中中链甘油三酯在亲水性脂类组合物中的含量以重量比计为30％～99％。The method of formulating a hydrophilic lipid composition according to claim 11 and a water-based liquid, wherein the liquid fat is selected from the group consisting of medium chain triglycerides and one or more of the following: oleic acid, Linoleic acid, linolenic acid, diglyceride, medium-long chain fatty acid, wherein the content of the medium chain triglyceride in the hydrophilic lipid composition is 30% to 99% by weight.
  18. 根据权利要求11所述的亲水性脂类组合物与水基液体调配成乳浊液的方法，所述乳化剂选自磷脂和下述一种或多种物质：蔗糖脂肪酸酯、单，双甘油脂肪酸酯、聚甘油脂肪酸酯、丙二醇脂肪酸酯、乳酸脂肪酸甘油酯、吐温20、吐温40、吐温60、吐温80、司盘20、司盘40、司盘60、司盘65、司盘80，其中乳化剂在亲水性脂类组合物中的含量以重量比计为0.1％～4％。The method of formulating a hydrophilic lipid composition according to claim 11 and an aqueous liquid into an emulsion selected from the group consisting of phospholipids and one or more of the following: sucrose fatty acid esters, single, Diglycerin fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty acid glyceride, Tween 20, Tween 40, Tween 60, Tween 80, Span 20, Span 40, Span 60, Span 65, Span 80, wherein the content of the emulsifier in the hydrophilic lipid composition is from 0.1% to 4% by weight.
  19. 根据权利要求11所述的亲水性脂类组合物与水基液体调配成乳浊液的方法，所述水基液体选自下述一种或多种物质的水溶液：蔗糖、葡萄糖、果糖、麦芽糖、壳寡糖、低聚果 糖、低聚木糖、聚葡萄糖、菊粉、牛磺酸、半胱氨酸、胱氨酸、甘氨酸、天冬氨酸、天冬酰胺、谷氨酸、谷氨酰胺、赖氨酸、精氨酸、鸟氨酸、维生素C、维生素B、左旋肉碱、叶酸、烟酸、胆碱、肌醇。The method of formulating a hydrophilic lipid composition according to claim 11 and a water-based liquid, wherein the water-based liquid is selected from the group consisting of an aqueous solution of one or more of the following: sucrose, glucose, fructose, Maltose, chitooligosaccharide, oligosaccharide Sugar, xylooligosaccharides, polydextrose, inulin, taurine, cysteine, cystine, glycine, aspartic acid, asparagine, glutamic acid, glutamine, lysine, fine Amino acid, ornithine, vitamin C, vitamin B, L-carnitine, folic acid, niacin, choline, inositol.
  20. 根据权利要求11所述的亲水性脂类组合物与水基液体调配成乳浊液的方法，所述水基液体选自动物乳液、动物蛋白粉的水乳浊液或植物蛋白粉的水乳浊液。The method of formulating a hydrophilic lipid composition according to claim 11 and an aqueous liquid, wherein the water-based liquid is selected from the group consisting of animal emulsions, aqueous emulsions of animal protein powders, and water of vegetable protein powders. Emulsion.
  21. 根据权利要求11所述的亲水性脂类组合物与水基液体调配成乳浊液的方法，所述亲水性脂类组合物中进一步含有下述一种或多种物质：叶黄素、叶黄素酯、辅酶Q10、胡萝卜素、虾青素、番茄红素、大豆异黄酮。The method of formulating a hydrophilic lipid composition according to claim 11 and a water-based liquid into an emulsion, the hydrophilic lipid composition further comprising one or more of the following substances: lutein , lutein ester, coenzyme Q10, carotene, astaxanthin, lycopene, soy isoflavones.
  22. 根据权利要求11所述的亲水性脂类组合物与水基液体调配成乳浊液的方法，所述亲水性脂类组合物采用以下方法制备，包括：The method of formulating a hydrophilic lipid composition according to claim 11 and an aqueous liquid into an emulsion, wherein the hydrophilic lipid composition is prepared by the following method, comprising:
    (1)配料：按配方称取乳化剂、液体脂肪、脂溶性物质，定容至所需生产量，搅拌混合、分散均匀；(1) Ingredients: Weigh the emulsifier, liquid fat and fat-soluble substance according to the formula, and dilute to the required production amount, stir and mix, and disperse evenly;
    (2)将(1)中配制好的液体置于乳化罐中，加热使液体温度为45℃以上，于搅拌转速大于500r/min的条件下，进行搅拌操作3～25min，然后在3～5min内迅速将液体冷却至25℃以下，停止搅拌，静置；或者，将(1)中配制好的液体置于乳化罐中，加热使液体温度为45℃以上，于均质机中进行压力为20～58MPa的均质，然后在3～5min内迅速将液体冷却至25℃以下，停止搅拌；(2) The liquid prepared in (1) is placed in an emulsification tank, heated to a temperature of 45 ° C or higher, and stirred at a stirring speed of more than 500 r/min for 3 to 25 minutes, and then at 3 to 5 minutes. The liquid is quickly cooled to below 25 ° C, the stirring is stopped, and the mixture is allowed to stand; or, the liquid prepared in (1) is placed in an emulsification tank, and the temperature of the liquid is 45 ° C or higher, and the pressure is performed in the homogenizer. Homogenization of 20 to 58 MPa, and then quickly cool the liquid to below 25 ° C within 3 to 5 minutes, and stop stirring;
    (3)灌装：将油状液体进行真空脱气，灌装，封口，包装、检验，即得。(3) Filling: The oily liquid is vacuum degassed, filled, sealed, packaged and inspected.
  23. 根据权利要求11所述的亲水性脂类组合物与水基液体调配成乳浊液的方法，所述亲水性脂类组合物采用以下方法制备，包括：The method of formulating a hydrophilic lipid composition according to claim 11 and an aqueous liquid into an emulsion, wherein the hydrophilic lipid composition is prepared by the following method, comprising:
    (1)配料：按配方称取乳化剂、液体脂肪、脂溶性物质，定容至所需生产量，搅拌混合、分散均匀；(1) Ingredients: Weigh the emulsifier, liquid fat and fat-soluble substance according to the formula, and dilute to the required production amount, stir and mix, and disperse evenly;
    (2)将(1)中配制好的液体置于乳化罐中，向油状液体中持续通入氮气或者保持乳化罐中的压强大于1.3大气压，并于搅拌转速大于300r/min的条件下进行搅拌操作3～25min，使油状液体呈现非透明状的富含氮气的泡沫型的油状液体，停止搅拌；(2) placing the liquid prepared in (1) in an emulsification tank, continuously introducing nitrogen into the oily liquid or keeping the pressure in the emulsification tank stronger than 1.3 atm, and stirring at a stirring speed of more than 300 r/min. After operation for 3 to 25 minutes, the oily liquid is rendered as a non-transparent nitrogen-rich foam-like oily liquid, and the stirring is stopped;
    (3)灌装：将(2)中制备的油状液体灌装于容器中，进一步对容器进行充入氮气，并使容器中气体压强大于1.2大气压，密封封口，包装、检验，即得。(3) Filling: The oily liquid prepared in (2) is filled in a container, and the container is further filled with nitrogen gas, and the gas pressure in the container is stronger than 1.2 atm, sealed and sealed, packaged, and inspected.
  24. 权利要求11所述的亲水性脂类组合物与水基液体调配成乳浊液的方法，在制备或调配药物、特殊医学用途配方食品、保健食品、营养食品或化妆品方面的应用。 A method for formulating a hydrophilic lipid composition according to claim 11 and a water-based liquid into an emulsion, for use in the preparation or formulation of a medicament, a special medical use formula, a health food, a nutraceutical or a cosmetic.
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