CN107693793B - Packaged compositions of hydrophilic lipid compositions, methods of preparation and formulation and uses thereof - Google Patents

Packaged compositions of hydrophilic lipid compositions, methods of preparation and formulation and uses thereof Download PDF

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Publication number
CN107693793B
CN107693793B CN201710841757.7A CN201710841757A CN107693793B CN 107693793 B CN107693793 B CN 107693793B CN 201710841757 A CN201710841757 A CN 201710841757A CN 107693793 B CN107693793 B CN 107693793B
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liquid
fat
lipid composition
emulsifier
content
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CN107693793A (en
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雷凡琦
王保红
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Jiangsu Hailaikang Biotechnology Co ltd
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Fujian Aozheng Investment Development Co ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/02—Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by the production or working-up
    • A23D7/04—Working-up
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/005—Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/005—Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
    • A23D7/0053—Compositions other than spreads
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/01—Other fatty acid esters, e.g. phosphatides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/01—Other fatty acid esters, e.g. phosphatides
    • A23D7/011—Compositions other than spreads
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/06—Preservation of finished products
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
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    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4993—Derivatives containing from 2 to 10 oxyalkylene groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/10—General cosmetic use

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Abstract

The invention provides a hydrophilic lipid composition containing an emulsifier and liquid fat, a packaging composition thereof, and a preparation and use method thereof, wherein the hydrophilic lipid composition has excellent hydrophilicity, can be quickly dissolved in water to form uniform and stable emulsion, is convenient for operation and meal preparation, can form uniform emulsion within 1-5 seconds by mixing and shaking, is beneficial to quick and convenient preparation of the lipid composition and water-based liquid, has the advantages of instant preparation and instant use, and is also beneficial to oral absorption and utilization of fat-soluble components; the invention also provides the application of the health-care food in the aspects of preparing medicines, formula foods with special medical application, health-care foods or nutritional foods, and the instant blending and the instant use of users are greatly facilitated.

Description

Packaged compositions of hydrophilic lipid compositions, methods of preparation and formulation and uses thereof
The invention relates to a health product composition, in particular to a packaging combination of a hydrophilic lipid composition, a preparation method thereof, and blending use and application thereof.
The health product composition comprises medicines, formula foods with special medical application, health foods, nutritional foods, cosmetics and the like, and particularly relates to a composition containing emulsifier and non-aqueous liquid fat.
In one aspect, it is well known that lipid materials including unsaturated fatty acids are completely incompatible with water, however, in the use of healthy products, lipid materials with healthy nutrition and water-soluble healthy nutrients are often used simultaneously, and the prior art is to prepare lipid materials and water-based liquids as emulsions for patients or special people, however, such pre-prepared emulsions, in order to maintain the stability of the emulsions and prolong the commercial shelf life, are added with a large amount of or excess emulsifier, and in order to maintain the stability of unsaturated fatty acids, are added with a large amount of antioxidant and preservative, and the pH of the emulsions is adjusted by using basic compounds, such as sodium hydroxide, which are not beneficial to the oral absorption of fatty acids and even bring health risks; furthermore, unsaturated fatty acids and esters, such as linolenic acid, linoleic acid, oleic acid, arachidonic acid, conjugated linoleic acid glyceride, DHA, EPA, nervonic acid, etc., are easily oxidized and degraded in aqueous mixed solution, and especially at the temperature above 40 ℃, the degradation is accelerated, so that a great amount of unsaturated fatty acids are lost, and the quality safety of the composition is seriously influenced.
On the other hand, lipid substances, especially unsaturated fatty acids, are very greasy and unacceptable when consumed directly; therefore, the unsaturated fatty acid is prepared into soft capsules for oral ingestion in the prior art, which is not favorable for the convenience of oral ingestion, is not favorable for the oral ingestion of larger dose, and is also not favorable for the oral ingestion.
Chinese patent publication nos. CN104397702A, CN104490773A, and CN104397706A disclose emulsion compositions containing phospholipids, other fat-soluble substances, and water, which are processed by high-speed stirring, emulsifying, and homogenizing to form uniform emulsion of the fat-soluble substances and water, which is beneficial for eating and absorption. Disadvantageously, however, the fat-soluble substances of unsaturated fatty acids are easily oxidized and degraded in the aqueous mixture, and especially at temperatures above 40 ℃, the degradation is accelerated, which results in a great loss of unsaturated fatty acids and seriously affects the quality safety of the composition.
In general, a lipid composition containing no water has good stability, but the lipid composition containing no water has strong oiliness, is completely insoluble in water and floats on the water surface, and cannot be uniformly mixed with water by stirring or shaking, so that the lipid composition is extremely unfavorable for the blending and use of the lipid composition, and the application range of the lipid composition in the use of medical products or health foods is severely limited, and particularly, the lipid composition is difficult to be uniformly mixed with an aqueous solution or be blended into a homogenized diet which can be orally taken in nutritional foods/special medical use formula foods; moreover, the blending with the water aqua is required to be carried out quickly and easily by a user, the blended mixed solution is emulsion, and the layering which is visible to naked eyes is not easy to occur, so that the edible and the use are facilitated.
In practical applications, the liquid fat containing no water should satisfy the following four conditions when being formulated with water-based liquids into a product state easy to be orally ingested, especially in practical applications or clinical uses such as formulation foods for nutritional foods, special medical uses, medicines, and the like:
1. hydrophilic and can be mixed with water-based liquid and dispersed to form emulsion to improve unacceptable greasy taste;
2. stirring or shaking with water-based liquid in a container can form uniform emulsion in a short time, such as 10 seconds, to ensure rapid and convenient preparation;
3. emulsions with water-based liquids have good stability and are not prone to significant delamination, e.g., no visible delamination for at least 1 minute, to allow the user a longer drinking or oral intake;
4. the formed emulsion can still form uniform emulsion after being layered after standing and being slightly shaken, so that the emulsion is convenient for a user to drink intermittently or take orally.
Obviously, the prior art fails to satisfy these four requirements for lipid compositions containing no water, and the lipid compositions containing no water are usually made into soft capsule preparations, which greatly limits the intake requirements of consumers or patients, for example, for patients who cannot swallow but need enteral nutrition support, the soft capsule preparations cannot be taken by tube feeding, and the oral absorption and utilization of fat-soluble substances are also limited.
Summary of the inventionthe object of the present invention is to provide a lipid composition having excellent hydrophilicity and rapidly dissolving in an aqueous liquid to form an emulsion, and a method for formulating the same. The lipid composition has excellent hydrophilicity, ensures the product quality of the lipid composition during production, storage, transportation and shelf life, is beneficial to being mixed and dissolved with water-based liquid during use, and can be conveniently and quickly used.
The present invention provides hydrophilic lipid compositions comprising a liquid fat and an emulsifier, which lipid compositions form emulsions upon mixing with a water-based liquid by shaking. Further, the invention also provides a packaging composition, a preparation method, a blending use and an application thereof.
The liquid fat is defined as fatty acid or oil which is liquid at normal temperature and pressure, and includes saturated or unsaturated fatty acid, saturated or unsaturated oil, triglyceride of saturated or unsaturated fatty acid, diglyceride of saturated or unsaturated fatty acid, such as but not limited to oleic acid, linoleic acid, linolenic acid, medium chain triglyceride, diglyceride, medium and long chain fatty acid, etc.
The invention provides a hydrophilic lipid composition containing an emulsifier, a fat-soluble substance A and a fat-soluble substance B, wherein the emulsifier is selected from one or more of the following substances: phospholipid, sucrose fatty acid ester, mono-diglycerol fatty acid ester, polyglycerol fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty glyceride, tween 20, tween 40, tween 60, tween 80, span 20, span 40, span 60, span 65 and span 80, wherein the content of the emulsifier is 0.05-8% by weight, preferably 0.1-6% by weight; the fat-soluble substance A is selected from one or more of the following substances: oleic acid, linoleic acid, linolenic acid, medium-chain triglyceride, diglyceride and medium-long chain fatty acid, wherein the content of the fat-soluble substance A is more than 45 percent in weight ratio; the fat-soluble substance B is selected from one or more of the following substances: nervonic acid (cis-15-tetracosenoic acid), DHA (docosahexaenoic acid), EPA (eicosapentaenoic acid), arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol ester, phytostanol ester, rice bran fatty alkanol, and polyene phosphatidyl choline, wherein the content of the fat-soluble substance B is 0-30% by weight, and preferably the content of the fat-soluble substance B is 0.01-30% by weight; the content of the fat-soluble substance B is 0-30% by weight, which means that the fat-soluble substance B does not contain the fat-soluble substance B and contains up to 30% of the fat-soluble substance B; the linolenic acid comprises alpha-linolenic acid or gamma-linolenic acid, and the medium-long chain fatty acid comprises a medium-chain fatty acid or a long-chain fatty acid.
The fat-soluble substance A and the fat-soluble substance B are both fatty acids or fat-soluble substances, and are usually extracted from vegetable oil or animal oil, or are compounds or grease which are further synthesized after being extracted from vegetable oil or animal oil (such as fish oil and krill oil), for example, lecithin is extracted from soybean oil or egg yolk, and phosphatidylserine is prepared by taking lecithin and L-serine as raw materials, adopting phospholipase for conversion reaction and purifying; as another example, phytosterols include beta-sitosterol, campesterol, stigmasterol, and the like extracted from soybean oil, rapeseed oil, corn oil, sunflower seed oil, tall oil, and the like;
on the other hand, the fat-soluble substance a or the fat-soluble substance B of the present invention is usually present in the fat or oil in a certain content ratio, and the fat-soluble substance a or the fat-soluble substance B of the present invention may be applied to the present invention as vegetable oil or animal oil containing the fat-soluble substance a or the fat-soluble substance B, or as a compound or fat extracted from vegetable oil or animal oil and then further synthesized or fermented. For example, perilla seed oil, linseed oil, peony seed oil, maytenia fruit oil or eucommia seed oil with alpha-linolenic acid content of more than 30% is used as a donor of the alpha-linolenic acid, and is applied to the invention; the gamma-linolenic acid grease with the gamma-linolenic acid content of more than 8 percent is used as a donor of the gamma-linolenic acid and is applied to the invention;
for example, soybean oil, corn oil, peanut oil, sunflower oil, olive oil, silybum marianum seed oil, almond oil, palm oil, sesame oil, walnut kernel oil, rapeseed oil, safflower seed oil, grape seed oil, rice bran oil, capsicum seed oil, zanthoxylum seed oil, canola oil, coconut oil, cottonseed oil, wheat germ oil, eucommia seed oil, tomato seed oil, silybum marianum seed oil, pumpkin seed oil, krill oil, tea oil including tea seed oil, camellia seed oil or tea tree oil, almond oil, cornus glabra fruit oil, suaeda salsa seed oil, meadow vine fruit oil, rhus chinensis fruit oil, peony seed oil, wing fruit oil, imperial rice oil, pomegranate seed oil, brucea javanica oil, evening primrose oil, blackcurrant oil, shea butter, litsea oil, hemp seed oil, walnut oil, canola oil or ginger oil having an oleic acid or linoleic acid content of greater than 40% are used as donors for oleic acid or linoleic acid, application to the present invention;
for example, the medium-long chain fatty acid edible oil contains more than 11% of medium-chain fatty acid and more than 10% of long-chain fatty acid, and the medium-long chain fatty acid edible oil can be used as a donor of the medium-long chain fatty acid, the medium-long chain fatty acid or the long-chain fatty acid and is applied to the invention;
for example, acer truncatum seed oil or shark oil with nervonic acid content of 3% -8% is used as the nervonic acid donor in the invention;
for example, DHA algae oil with DHA content of 3% to 6% is used as a donor of DHA in the present invention, fish oil or fish oil extract with DHA content of 3% to 15% is used as a donor of DHA in the present invention, and krill oil with DHA content of more than 3% is used as a donor of DHA in the present invention;
for example, soybean phospholipids, krill oil, soybean lecithin, egg yolk phospholipids, and egg yolk lecithin having a total phospholipid content of more than 35% are used as phospholipid donors in the present invention.
Further, the present invention provides a hydrophilic lipid composition comprising an emulsifier selected from one or more of the following: phospholipid, sucrose fatty acid ester, mono-diglycerol fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty glyceride, tween 20, tween 40, tween 60, tween 80, span 20, span 40, span 60, span 65 and span 80; wherein the content of the emulsifier is 0.05-8% by weight, preferably 0.1-6% by weight; the fat-soluble substance A is selected from medium-chain triglyceride and one or more of the following substances: oleic acid, linoleic acid, alpha-linolenic acid, gamma-linolenic acid, diglyceride, medium-long chain fatty acid, wherein the content of medium-chain triglyceride in the hydrophilic lipid composition is 30-99% by weight, preferably the content of medium-chain triglyceride is 40-99% by weight, and preferably the content of medium-chain triglyceride is 45-98% by weight; the fat-soluble substance B is selected from one or more of the following substances: nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol ester, phytostanol ester, rice bran fatty alkanol and polyene phosphatidyl choline, wherein the content of the fat-soluble substance B is 0-30% by weight, and preferably the content of the fat-soluble substance B is 0.01-30% by weight; the medium-long chain fatty acid comprises medium-chain fatty acid or long-chain fatty acid, the emulsifier also comprises various types, specifications, polymerization degree, esterification degree, mono/diester or monomer components contained in the emulsifier, and the phospholipid comprises lecithin, phosphatidylethanolamine, phosphatidylinositol or phosphatidylglycerol;
the content of the fat-soluble substance B is 0.01 to 30% by weight, preferably 0.05 to 25% by weight, more preferably 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.4%, 3.5%, 4.5%, 4%, 4.5%, 4%, 3.5%, 4%, 3.5%, 4%, 4.5%, 4%, 3%, 3.5%, 4% of the content of the fat, 5.6%, 5.7%, 5.8%, 5.9%, 6%, 6.1%, 6.2%, 6.3%, 6.4%, 6.5%, 6.6%, 6.7%, 6.8%, 6.9%, 7%, 7.1%, 7.2%, 7.3%, 7.4%, 7.5%, 7.6%, 7.7%, 7.8%, 7.9%, 8%, 8.1%, 8.2%, 8.3%, 8.4%, 8.5%, 8.6%, 8.7%, 8.8%, 8.9%, 9%, 9.1%, 9.2%, 9.3%, 9.4%, 9.5%, 9.6%, 9.7%, 9.8%, 9.9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%.
Further, the present invention provides a hydrophilic lipid composition comprising an emulsifier selected from one or more of the following: phospholipid, sucrose fatty acid ester, mono-diglycerol fatty acid ester, polyglycerol fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty glyceride, tween 20, tween 40, tween 60, tween 80, span 20, span 40, span 60, span 65 and span 80, wherein the content of the emulsifier is 0.05-8% by weight; the fat-soluble substance A is selected from linolenic acid and one or more of the following substances: oleic acid, linoleic acid, medium chain triglyceride, diglyceride and medium-long chain fatty acid, wherein the content of the linolenic acid in the hydrophilic lipid composition is 30-99 percent by weight; the fat-soluble substance B is selected from one or more of the following substances: nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol ester, phytostanol ester, rice bran fatty alkanol and polyene phosphatidyl choline, wherein the content of fat-soluble substances B is 0.01-30% by weight, and the linolenic acid comprises alpha-linolenic acid or gamma-linolenic acid.
Further, the present invention provides a hydrophilic lipid composition comprising an emulsifier selected from one or more of the following: phospholipid, sucrose fatty acid ester, mono-diglycerol fatty acid ester, polyglycerol fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty glyceride, tween 20, tween 40, tween 60, tween 80, span 20, span 40, span 60, span 65 and span 80, wherein the content of the emulsifier is 0.05-8% by weight; the fat-soluble substance A is selected from linoleic acid and one or more of the following substances: oleic acid, alpha-linolenic acid, gamma-linolenic acid, medium chain triglyceride, diglyceride and medium-long chain fatty acid, wherein the content of the linoleic acid in the hydrophilic lipid composition is 30 to 99 percent by weight; the fat-soluble substance B is selected from one or more of the following substances: nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol ester, phytostanol ester, rice bran fatty alkanol and polyene phosphatidyl choline, wherein the content of the fat-soluble substance B is 0.01-30% by weight.
Further, the present invention provides a hydrophilic lipid composition comprising an emulsifier selected from one or more of the following: phospholipid, sucrose fatty acid ester, mono-diglycerol fatty acid ester, polyglycerol fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty glyceride, tween 20, tween 40, tween 60, tween 80, span 20, span 40, span 60, span 65 and span 80, wherein the content of the emulsifier is 0.05-8% by weight; the fat-soluble substance A is selected from oleic acid and one or more of the following substances: linoleic acid, alpha-linolenic acid, gamma-linolenic acid, medium chain triglyceride, diglyceride and medium-long chain fatty acid, wherein the content of the oleic acid in the hydrophilic lipid composition is 30-99 percent by weight; the fat-soluble substance B is selected from one or more of the following substances: nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol ester, phytostanol ester, rice bran fatty alkanol and polyene phosphatidyl choline, wherein the content of the fat-soluble substance B is 0.01-30% by weight.
More specifically, the present invention provides a hydrophilic lipid composition comprising an emulsifier, medium chain triglycerides and a lipid-soluble substance a selected from one or more of oleic acid, linoleic acid, alpha-linolenic acid, gamma-linolenic acid, medium-long chain fatty acids, diglycerides, wherein the content of medium chain triglycerides and lipid-soluble substance a is more than 45% by weight, the content of emulsifier is 0.05 to 8% by weight, preferably the content of emulsifier is 0.1 to 6% by weight, most preferably the content of emulsifier is 0.3 to 2.5% by weight.
More specifically, the present invention provides a hydrophilic lipid composition comprising an emulsifier, medium-chain triglycerides and a fat-soluble substance B selected from one or more of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin a, vitamin D, conjugated linoleic acid glycerides, phosphatidylserine, phytosterol esters, phytostanol esters, rice bran fatty alkanols, and polyene phosphatidylcholine, wherein the medium-chain triglycerides are contained in an amount of 60 to 99.5% by weight, the emulsifier is contained in an amount of 0.05 to 8% by weight, preferably the emulsifier is contained in an amount of 0.1 to 6% by weight, the fat-soluble substance B is contained in an amount of 0.01 to 30% by weight, preferably the fat-soluble substance B is contained in an amount of 0.05 to 25% by weight, and preferably the fat-soluble substance B is contained in an amount of 0.01% by weight, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 7.5%, 6%, 7.6%, 6.5%, 7.6%, 6.6%, 7.6%, 6%, 6.5%, 7.6%, 6%, 7.6%, 6.6%, 7%, 6%, 6.5%, 7.6%, 6%, 6.5%, 7%, 6%, 6.6%, 7%, 6.6%, 6%, 7%, 6%, 6.6%, 7.6.6%, 7%, 6%, 7%, 6%, 6.5%, 7%, 6%, 6.6.6%, 7%, 6%, 6.6%, 7.6%, 6%, 7.6%, 7%, 6, 7.8%, 7.9%, 8%, 8.1%, 8.2%, 8.3%, 8.4%, 8.5%, 8.6%, 8.7%, 8.8%, 8.9%, 9%, 9.1%, 9.2%, 9.3%, 9.4%, 9.5%, 9.6%, 9.7%, 9.8%, 9.9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%.
Specifically, the invention provides a hydrophilic lipid composition containing an emulsifier, nervonic acid and a fat-soluble substance A, wherein the fat-soluble substance A is selected from one or more of oleic acid, linoleic acid, linolenic acid, medium-chain triglyceride, medium-long-chain fatty acid and diglyceride, the content of the fat-soluble substance A is more than 45% by weight, the content of the emulsifier is 0.05-8% by weight, the content of the emulsifier is preferably 0.1-6% by weight, the content of the nervonic acid is 0.01-30% by weight, the content of the nervonic acid is preferably 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 0.9%, 1.1.1%, 1%, 1.4%, 1.5%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5%, 5.1%, 5.2%, 5.3%, 5.4%, 5.5%, 5.6%, 5.7%, 5.8%, 5.9%, 6%, 6.1%, 6.2%, 6.3%, 6.4%, 6.5%, 6.6%, 6.7%, 6.8%, 6.9%, 7%, 7.1%, 7.2%, 7.3%, 7.4%, 7.6%, 7.9%, 8%, 8.9%, 8%, 8.9.9%, 8.9%, 8%, 8.9.9%, 8%, 8.9%, 8%, 9.9%, 8%, 7.9.9%, 8%, 8.9%, 8%, 8.9.9%, 8.9.6%, 7%, 8%, 7%, 8%, 8.9.9%, 8%, 9.9.9%, 9%, 7.9%, 7.9.9%, 8%, 8.6%, 8, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%.
Specifically, the invention provides a hydrophilic lipid composition containing an emulsifier, DHA and a fat-soluble substance A, wherein the fat-soluble substance A is selected from one or more of oleic acid, linoleic acid, linolenic acid, medium-chain triglyceride, medium-long chain fatty acid and diglyceride, the content of the fat-soluble substance A is more than 45% by weight, the content of the emulsifier is 0.05-8% by weight, the content of the emulsifier is preferably 0.1-6% by weight, the content of DHA is 0.01-30% by weight, and the content of DHA is preferably 0.04-25% by weight.
Specifically, the invention provides a hydrophilic lipid composition containing an emulsifier, EPA and a fat-soluble substance A, wherein the fat-soluble substance A is selected from one or more of oleic acid, linoleic acid, linolenic acid, medium-chain triglyceride, medium-long chain fatty acid and diglyceride, the content of the fat-soluble substance A is more than 45% by weight, the content of the emulsifier is 0.05-8% by weight, the content of the emulsifier is preferably 0.1-6% by weight, the content of the EPA is 0.01-30% by weight, and the content of the EPA is preferably 0.04-25% by weight.
Specifically, the present invention provides a hydrophilic lipid composition comprising an emulsifier, arachidonic acid, and a fat-soluble substance a selected from one or more of oleic acid, linoleic acid, linolenic acid, medium-chain triglycerides, medium-and long-chain fatty acids, and diglycerides, wherein the content of the fat-soluble substance a is more than 45% by weight, the content of the emulsifier is 0.05 to 8% by weight, preferably the content of the emulsifier is 0.1 to 6% by weight, the content of the arachidonic acid is 0.01 to 30% by weight, and preferably the content of the arachidonic acid is 0.04 to 25% by weight.
Specifically, the invention provides a hydrophilic lipid composition containing an emulsifier, vitamin E and a fat-soluble substance A, wherein the fat-soluble substance A is selected from one or more of oleic acid, linoleic acid, linolenic acid, medium-chain triglyceride, medium-long chain fatty acid and diglyceride, the content of the fat-soluble substance A is more than 45% by weight, the content of the emulsifier is 0.05-8% by weight, the content of the emulsifier is preferably 0.1-6% by weight, the content of the vitamin E is 0.01-30% by weight, and the content of the vitamin E is preferably 0.04-25% by weight.
Specifically, the present invention provides a hydrophilic lipid composition comprising an emulsifier, conjugated linoleic acid, and a fat-soluble substance a selected from one or more of oleic acid, linoleic acid, linolenic acid, medium-chain triglycerides, medium-long-chain fatty acids, and diglycerides, wherein the content of the fat-soluble substance a is greater than 45% by weight, the content of the emulsifier is 0.05% to 8% by weight, preferably the content of the emulsifier is 0.1% to 6% by weight, the content of the conjugated linoleic acid is 0.01% to 25% by weight, and preferably the content of the conjugated linoleic acid is 0.04% to 20% by weight.
Specifically, the invention provides a hydrophilic lipid composition containing an emulsifier, conjugated linoleic acid glyceride and a fat-soluble substance A, wherein the fat-soluble substance A is selected from one or more of oleic acid, linoleic acid, linolenic acid, medium-chain triglyceride, medium-long-chain fatty acid and diglyceride, the content of the fat-soluble substance A is more than 45% by weight, the content of the emulsifier is 0.05-8% by weight, the content of the emulsifier is preferably 0.1-6% by weight, the content of the conjugated linoleic acid glyceride is 0.01-25% by weight, and the content of the conjugated linoleic acid glyceride is preferably 0.04-20% by weight.
Specifically, the invention provides a hydrophilic lipid composition containing an emulsifier, phosphatidylserine and a fat-soluble substance A, wherein the fat-soluble substance A is selected from one or more of oleic acid, linoleic acid, linolenic acid, medium-chain triglyceride, medium-long chain fatty acid and diglyceride, the content of the fat-soluble substance A is more than 45% by weight, the content of the emulsifier is 0.05-8% by weight, the content of the emulsifier is preferably 0.1-6% by weight, the content of the phosphatidylserine is 0.01-30% by weight, and the content of the phosphatidylserine is preferably 0.04-25% by weight.
Specifically, the invention provides a hydrophilic lipid composition containing an emulsifier, polyene phosphatidyl choline and a fat-soluble substance A, wherein the fat-soluble substance A is selected from one or more of oleic acid, linoleic acid, linolenic acid, medium-chain triglyceride, medium-long-chain fatty acid and diglyceride, the content of the fat-soluble substance A is more than 45% by weight, the content of the emulsifier is 0.05-8% by weight, the content of the emulsifier is preferably 0.1-6% by weight, the content of the polyene phosphatidyl choline is 0.01-25% by weight, and the content of the polyene phosphatidyl choline is preferably 0.04-25% by weight.
Specifically, the invention provides a hydrophilic lipid composition containing an emulsifier, phytosterol and a fat-soluble substance A, wherein the fat-soluble substance A is selected from one or more of oleic acid, linoleic acid, linolenic acid, medium-chain triglyceride, medium-long chain fatty acid and diglyceride, the content of the fat-soluble substance A is more than 45% by weight, the content of the emulsifier is 0.05-8% by weight, the content of the emulsifier is preferably 0.1-6% by weight, the content of the phytosterol is 0.01-30% by weight, and the content of the phytosterol is preferably 0.04-25% by weight.
Specifically, the invention provides a hydrophilic lipid composition containing an emulsifier, a phytosterol ester and a fat-soluble substance A, wherein the fat-soluble substance A is selected from one or more of oleic acid, linoleic acid, linolenic acid, medium-chain triglyceride, medium-long-chain fatty acid and diglyceride, the content of the fat-soluble substance A is more than 45% by weight, the content of the emulsifier is 0.05-8% by weight, the content of the emulsifier is preferably 0.1-6% by weight, the content of the phytosterol ester is 0.01-30% by weight, and the content of the phytosterol ester is preferably 0.05-26% by weight.
Specifically, the invention provides a hydrophilic lipid composition containing an emulsifier, a phytostanol ester and a fat-soluble substance A, wherein the fat-soluble substance A is selected from one or more of oleic acid, linoleic acid, linolenic acid, medium-chain triglycerides, medium-long-chain fatty acids and diglycerides, the content of the fat-soluble substance A is more than 45% by weight, the content of the emulsifier is 0.05-8% by weight, preferably the content of the emulsifier is 0.1-6% by weight, the content of the phytostanol ester is 0.01-30% by weight, and preferably the content of the phytostanol ester is 0.04-25% by weight.
In particular, the invention provides a hydrophilic lipid composition comprising linolenic acid, an emulsifier and a fat-soluble substance B, wherein the fat-soluble substance B is selected from one or more of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol ester, phytostanol ester, rice bran fatty alkanol and polyene phosphatidylcholine, and the linolenic acid comprises alpha-linolenic acid or gamma-linolenic acid, wherein the content of the linolenic acid is 45-99.5% by weight, the content of the emulsifier is 0.05-8% by weight, the content of the emulsifier is preferably 0.3-2.5% by weight, the content of the fat-soluble substance B is 0.01-30% by weight, the content of the fat-soluble substance B is preferably 0.05-20% by weight, preferably, the content of the fat-soluble substance B is 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.5%, 6%, 6.5%, 6.6%, 6%, 6.7%, 6.5%, 6%, 6.5%, 6%, 6.6%, 6%, 6.5%, 6%, 6.7%, 6%, 6.5%, 6%, 7.1%, 7.2%, 7.3%, 7.4%, 7.5%, 7.6%, 7.7%, 7.8%, 7.9%, 8%, 8.1%, 8.2%, 8.3%, 8.4%, 8.5%, 8.6%, 8.7%, 8.8%, 8.9%, 9%, 9.1%, 9.2%, 9.3%, 9.4%, 9.5%, 9.6%, 9.7%, 9.8%, 9.9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%.
The invention provides a hydrophilic lipid composition, which contains linoleic acid, an emulsifier and a fat-soluble substance B, the fat-soluble substance B is selected from one or more of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid glyceride, phosphatidyl serine, phytosterol ester, phytostanol ester, rice bran fatty alkanol and polyene phosphatidyl choline, wherein the content of linoleic acid is 45-99% by weight, the content of emulsifier is 0.05-8% by weight, the content of emulsifier is preferably 0.3-2.5% by weight, the content of fat-soluble substance B is 0.01-30% by weight, the content of fat-soluble substance B is preferably 0.04-25% by weight, and the content of fat-soluble substance B is preferably 0.06-23% by weight.
The invention provides a hydrophilic lipid composition, which contains oleic acid, an emulsifier and a fat-soluble substance B, wherein the fat-soluble substance B is selected from one or more of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol ester, phytostanol ester, rice bran fatty alkanol and polyene phosphatidyl choline, the content of the oleic acid is 45-99% by weight, the content of the emulsifier is 0.05-8% by weight, the content of the emulsifier is preferably 0.3-2.5% by weight, the content of the fat-soluble substance B is 0.01-30% by weight, and the content of the fat-soluble substance B is preferably 0.05-20% by weight.
The invention provides a hydrophilic lipid composition, which contains medium-chain triglyceride, an emulsifier and a fat-soluble substance B, wherein the fat-soluble substance B is selected from one or more of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol ester, phytostanol ester, rice bran fatty alkanol and polyene phosphatidyl choline, the content of the medium-chain triglyceride is 40-99.5% by weight, the content of the emulsifier is 0.05-8% by weight, the content of the emulsifier is preferably 0.1-6% by weight, the content of the fat-soluble substance B is 0.01-30% by weight, and the content of the fat-soluble substance B is preferably 0.05-25% by weight.
The invention provides a hydrophilic lipid composition, which comprises diglyceride, an emulsifier and a fat-soluble substance B, wherein the fat-soluble substance B is selected from one or more of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol ester, phytostanol ester, rice bran fatty alkanol and polyene phosphatidyl choline, the content of the diglyceride is 45-99% by weight, the content of the emulsifier is 0.05-8% by weight, the content of the emulsifier is preferably 0.3-2.5% by weight, the content of the fat-soluble substance B is 0.01-30% by weight, and the content of the fat-soluble substance B is preferably 0.05-20% by weight.
The invention provides a hydrophilic lipid composition, which contains medium-long chain fatty acid, an emulsifier and a fat-soluble substance B, wherein the fat-soluble substance B is selected from one or more of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol ester, phytostanol ester, rice bran fatty alkanol and polyene phosphatidyl choline, wherein the content of the medium-long chain fatty acid is 45-99% by weight, the content of the emulsifier is 0.05-8% by weight, the content of the emulsifier is preferably 0.3-2.5% by weight, the content of the fat-soluble substance B is 0.01-30% by weight, and the content of the fat-soluble substance B is preferably 0.05-20% by weight.
The invention provides a hydrophilic lipid composition, which contains oleic acid, linoleic acid, an emulsifier and a fat-soluble substance B, wherein the fat-soluble substance B is selected from one or more of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol ester, phytostanol ester, rice bran fatty alkanol and polyene phosphatidyl choline, the total content of the oleic acid and the linoleic acid is 45-99% by weight, the content of the emulsifier is 0.05-8% by weight, the content of the emulsifier is preferably 0.1-6% by weight, the content of the fat-soluble substance B is 0.01-30% by weight, and the content of the fat-soluble substance B is preferably 0.05-20% by weight.
The invention provides a hydrophilic lipid composition, which comprises linolenic acid, linoleic acid, an emulsifier and a fat-soluble substance B, wherein the fat-soluble substance B is selected from one or more of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol ester, phytostanol ester, rice bran fatty alkanol and polyene phosphatidyl choline, the total content of the linolenic acid and the linoleic acid is 45-99% by weight, the content of the emulsifier is 0.05-8% by weight, the content of the emulsifier is preferably 0.1-6% by weight, the content of the fat-soluble substance B is 0.01-30% by weight, and the content of the fat-soluble substance B is preferably 0.05-20% by weight.
The invention provides a hydrophilic lipid composition, which comprises linolenic acid, medium-chain triglyceride, an emulsifier and a fat-soluble substance B, wherein the fat-soluble substance B is selected from one or more of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol ester, phytostanol ester, rice bran fatty alkanol and polyene phosphatidylcholine, wherein the total content of the linolenic acid and the medium-chain triglyceride is 45-99% by weight, the content of the emulsifier is 0.05-8% by weight, the content of the emulsifier is preferably 0.1-6% by weight, the content of the fat-soluble substance B is 0.01-30% by weight, and the content of the fat-soluble substance B is preferably 0.05-20% by weight.
The invention provides a hydrophilic lipid composition, which contains linoleic acid, medium-chain triglyceride, an emulsifier and a fat-soluble substance B, wherein the fat-soluble substance B is selected from one or more of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol ester, phytostanol ester, rice bran fatty alkanol and polyene phosphatidylcholine, wherein the total content of the linoleic acid and the medium-chain triglyceride is 45-99% by weight, the content of the emulsifier is 0.05-8% by weight, the content of the emulsifier is preferably 0.1-6% by weight, the content of the fat-soluble substance B is 0.01-30% by weight, and the content of the fat-soluble substance B is preferably 0.05-20% by weight.
The invention provides a hydrophilic lipid composition, which contains medium-chain triglyceride, linoleic acid, linolenic acid, an emulsifier and a fat-soluble substance B, the fat-soluble substance B is selected from one or more of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid glyceride, phosphatidyl serine, phytosterol ester, phytostanol ester, rice bran fatty alkanol and polyene phosphatidyl choline, wherein the total content of the medium chain triglyceride, the linoleic acid and the linolenic acid is 45 to 99 percent by weight, the content of the emulsifier is 0.05 to 8 percent by weight, the content of the emulsifier is preferably 0.1 to 6 percent by weight, the content of the fat-soluble substance B is 0.01 to 30 percent by weight, and the content of the fat-soluble substance B is preferably 0.05 to 20 percent by weight.
The invention provides a hydrophilic lipid composition, which contains medium-chain triglyceride, linolenic acid, linoleic acid, oleic acid, an emulsifier and a fat-soluble substance B, the fat-soluble substance B is selected from one or more of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid glyceride, phosphatidyl serine, phytosterol ester, phytostanol ester, rice bran fatty alkanol and polyene phosphatidyl choline, wherein the total content of the medium chain triglyceride, the linolenic acid, the linoleic acid and the oleic acid is 45-99 percent by weight, the content of the emulsifier is 0.05-8 percent by weight, the content of the emulsifier is preferably 0.1-6 percent by weight, the content of the fat-soluble substance B is 0.01-30 percent by weight, and the content of the fat-soluble substance B is preferably 0.05-20 percent by weight.
The invention provides a hydrophilic lipid composition, which contains medium-chain triglyceride, medium-chain and long-chain fatty acid, an emulsifier and a fat-soluble substance B, the fat-soluble substance B is selected from one or more of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid glyceride, phosphatidyl serine, phytosterol ester, phytostanol ester, rice bran fatty alkanol and polyene phosphatidyl choline, wherein the total content of the medium-chain triglyceride and the medium-chain fatty acid is 45-99 percent by weight, the content of the emulsifier is 0.05-8 percent by weight, the content of the emulsifier is preferably 0.1-6 percent by weight, the content of the fat-soluble substance B is 0.01-30 percent by weight, and the content of the fat-soluble substance B is preferably 0.05-20 percent by weight.
The invention provides a hydrophilic lipid composition, which contains medium-chain triglyceride, diglyceride, emulsifier and fat-soluble substance B, wherein the fat-soluble substance B is selected from one or more of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol ester, phytostanol ester, rice bran fatty alkanol and polyene phosphatidyl choline, the total content of the medium-chain triglyceride and the diglyceride is 45-99% by weight, the content of the emulsifier is 0.05-8% by weight, the content of the emulsifier is preferably 0.1-6% by weight, and the content of the fat-soluble substance B is 0.01-30% by weight.
The invention provides a hydrophilic lipid composition, which comprises linolenic acid, diglyceride, an emulsifier and a fat-soluble substance B, wherein the fat-soluble substance B is selected from one or more of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol ester, phytostanol ester, rice bran fatty alkanol and polyene phosphatidyl choline, the total content of the linolenic acid and the diglyceride is 45-99% by weight, the content of the emulsifier is 0.05-8% by weight, the content of the emulsifier is preferably 0.1-6% by weight, the content of the fat-soluble substance B is 0.01-30% by weight, and the content of the fat-soluble substance B is preferably 0.05-20% by weight.
The invention provides a hydrophilic lipid composition, which contains diglyceride, linoleic acid, an emulsifier and a fat-soluble substance B, wherein the fat-soluble substance B is selected from one or more of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol ester, phytostanol ester, rice bran fatty alkanol and polyene phosphatidyl choline, the total content of the diglyceride and the linoleic acid is 45-99% by weight, the content of the emulsifier is 0.05-8% by weight, the content of the emulsifier is preferably 0.1-6% by weight, the content of the fat-soluble substance B is 0.01-30% by weight, and the content of the fat-soluble substance B is preferably 0.05-20% by weight.
The invention provides a hydrophilic lipid composition, which contains diglyceride, linoleic acid, linolenic acid, an emulsifier and a fat-soluble substance B, wherein the fat-soluble substance B is selected from one or more of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol ester, phytostanol ester, rice bran fatty alkanol and polyene phosphatidyl choline, the total content of the diglyceride, the linoleic acid and the linolenic acid is 45-99% by weight, the content of the emulsifier is 0.05-8% by weight, the content of the emulsifier is preferably 0.1-6% by weight, the content of the fat-soluble substance B is 0.01-30% by weight, and the content of the fat-soluble substance B is preferably 0.05-20% by weight.
The invention provides a hydrophilic lipid composition, which contains medium-long chain fatty acid, diglyceride, emulsifier and fat-soluble substance B, wherein the fat-soluble substance B is selected from one or more of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol ester, phytostanol ester, rice bran fatty alkanol and polyene phosphatidyl choline, the total content of the medium-long chain fatty acid and the diglyceride is 45-99% by weight, the content of the emulsifier is 0.05-8% by weight, the content of the emulsifier is preferably 0.1-6% by weight, the content of the fat-soluble substance B is 0.01-30% by weight, and the content of the fat-soluble substance B is preferably 0.05-20% by weight.
The invention provides a hydrophilic lipid composition, which contains linolenic acid, medium-long chain fatty acid, an emulsifier and a fat-soluble substance B, wherein the fat-soluble substance B is selected from one or more of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol ester, phytostanol ester, rice bran fatty alkanol and polyene phosphatidylcholine, wherein the total content of the linolenic acid and the medium-long chain fatty acid is 45-99% by weight, the content of the emulsifier is 0.05-8% by weight, the content of the emulsifier is preferably 0.1-6% by weight, the content of the fat-soluble substance B is 0.01-30% by weight, and the content of the fat-soluble substance B is preferably 0.05-20% by weight.
The invention provides a hydrophilic lipid composition, which contains linoleic acid, medium-long chain fatty acid, an emulsifier and a fat-soluble substance B, wherein the fat-soluble substance B is selected from one or more of nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol ester, phytostanol ester, rice bran fatty alkanol and polyene phosphatidylcholine, wherein the total content of the linoleic acid and the medium-long chain fatty acid is 45-99% by weight, the content of the emulsifier is 0.05-8% by weight, the content of the emulsifier is preferably 0.1-6% by weight, the content of the fat-soluble substance B is 0.01-30% by weight, and the content of the fat-soluble substance B is preferably 0.05-20% by weight.
The emulsifier is selected from one or more of the following substances: phospholipid, sucrose fatty acid ester, mono-diglycerol fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty glyceride, tween 20, tween 40, tween 60, tween 80, span 20, span 40, span 60, span 65 and span 80; wherein the content of the emulsifier is 0.05-8% by weight, preferably 0.1-6% by weight;
preferably, in the hydrophilic lipid composition, the content of the emulsifier is 0.07-7% by weight;
preferably, in the hydrophilic lipid composition, the content of the emulsifier is 0.1-6% by weight;
preferably, in the hydrophilic lipid composition, the content of the emulsifier is 0.2-5% by weight;
preferably, in the hydrophilic lipid composition, the content of the emulsifier is 0.3-4% by weight;
preferably, in the hydrophilic lipid composition, the content of the emulsifier is 0.4-3.5% by weight;
preferably, in the hydrophilic lipid composition, the content of the emulsifier is 0.5-3% by weight;
preferably, in the hydrophilic lipid composition, the content of the emulsifier is 0.6-2.5% by weight;
preferably, in the hydrophilic lipid composition, the content of the emulsifier is 0.75-2% by weight;
preferably, in the hydrophilic lipid composition, the content of the emulsifier is 0.8-1.8% by weight;
preferably, in the hydrophilic lipid composition, the content of the emulsifier is 0.85-1.7% by weight;
preferably, in the hydrophilic lipid composition, the content of the emulsifier is 0.9-1.6% by weight;
preferably, in the hydrophilic lipid composition, the content of the emulsifier is 0.95-1.5% by weight;
preferably, in the hydrophilic lipid composition, the content of the emulsifier is 1.0-1.4% by weight;
preferably, in the hydrophilic lipid composition, the content of the emulsifier is 0.4-1.6% by weight;
preferably, in the hydrophilic lipid composition, the content of the emulsifier is 0.5-1.5% by weight;
preferably, in the hydrophilic lipid composition, the content of the emulsifier is 0.6-1.4% by weight;
preferably, in the hydrophilic lipid composition, the content of the emulsifier is 0.7-1.3% by weight;
preferably, the content of the emulsifier in the hydrophilic lipid composition is 0.8-1.2% by weight.
Wherein, the emulsifier also comprises various types, specifications, polymerization degree, esterification degree, mono/diester or monomer components contained in the emulsifier. Specifically, the phospholipid includes, but is not limited to, lecithin, phosphatidylethanolamine, phosphatidylinositol or phosphatidylglycerol, preferably, the content of lecithin (i.e. phosphatidylcholine) in the phospholipid is more than 40%, preferably, the content of lecithin in the phospholipid is more than 50%; preferably the lecithin content of the phospholipids is greater than 60%; sucrose fatty acid esters include, but are not limited to, the various S-1 to S-16 versions thereof; mono, diglycerol fatty acid esters include, but are not limited to, glycerol mono, distearate, glycerol mono, dioleate, glycerol mono, dilaurate, glycerol mono, dilinoleate, glycerol mono, dipalmitate, glycerol mono, dibehenate; polyglycerol fatty acid esters include, but are not limited to, polyglycerol stearate, polyglycerol oleate, polyglycerol laurate, dimer, trimer, tetramer, hexamer, nonamer of polyglycerol myristate or polyglycerol palmitate, and the like, for example including, but not limited to, triglycerol stearate, triglycerol oleate, triglycerol laurate, triglycerol myristate, triglycerol palmitate, tetraglycerol oleate, tetraglycerol laurate, tetraglycerol myristate, tetraglycerol palmitate, diglycerol stearate, diglycerol oleate, diglycerol laurate, diglycerol myristate, diglycerol palmitate, diglycerol stearate, nonaglycerol stearate, and the like; propylene glycol fatty acid esters including, but not limited to, propylene glycol oleate, propylene glycol linoleate, propylene glycol stearate, and the like; the glycerol lactate fatty acid esters include, but are not limited to, glycerol lactate esters of oleic acid, linoleic acid, stearic acid, linolenic acid, and the like.
Preferably, the emulsifier is a phospholipid, wherein the content of the phospholipid is 0.2-3.5% by weight, and the content of the phospholipid is preferably 0.5-2.5% by weight.
Preferably, the emulsifier is selected from phospholipids and one or more of the following: sucrose fatty acid ester, mono-diglycerol fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty glyceride, tween 20, tween 40, tween 60, tween 80, span 20, span 40, span 60, span 65 and span 80; wherein the content of the emulsifier is 0.1-4% by weight, preferably 0.2-3% by weight.
Preferably, the emulsifier comprises a sucrose fatty acid ester and one or more of the following: phospholipid, mono-diglycerol fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty glyceride, tween 20, tween 40, tween 60, tween 80, span 20, span 40, span 60, span 65 and span 80; wherein the content of the emulsifier is 0.06-5% by weight, preferably 0.3-3% by weight.
Preferably, the emulsifier comprises mono-and diglycerol fatty acid esters and one or more of the following: phospholipid, sucrose fatty acid ester, polyglycerol fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty glyceride, tween 20, tween 40, tween 60, tween 80, span 20, span 40, span 60, span 65 and span 80; wherein the content of the emulsifier is 0.06-5% by weight, preferably 0.3-3% by weight.
Preferably, the emulsifier comprises a polyglyceryl fatty acid ester and one or more of the following: phospholipid, sucrose fatty acid ester, mono-diglycerol fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty acid glyceride, tween 20, tween 40, tween 60, tween 80, span 20, span 40, span 60, span 65 and span 80; wherein the content of the emulsifier is 0.06-5% by weight, preferably 0.3-3% by weight.
Preferably, the emulsifier comprises a propylene glycol fatty acid ester and one or more of the following: phospholipid, sucrose fatty acid ester, polyglycerol fatty acid ester, mono-diglycerol fatty acid ester, lactic acid fatty acid glyceride, tween 20, tween 40, tween 60, tween 80, span 20, span 40, span 60, span 65 and span 80; wherein the content of the emulsifier is 0.06-5% by weight, preferably 0.3-3% by weight.
Preferably, the emulsifier comprises fatty acid glyceride lactate and one or more of the following: phospholipid, sucrose fatty acid ester, polyglycerol fatty acid ester, mono-diglycerol fatty acid ester, propylene glycol fatty acid ester, tween 20, tween 40, tween 60, tween 80, span 20, span 40, span 60, span 65 and span 80; wherein the content of the emulsifier is 0.06-5% by weight, preferably 0.3-3% by weight.
Specifically, it is preferable that the content of the emulsifier according to the present invention is 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.5%, 6%, 6.5%, 6%, 6.5%, 6%, 7%, 6%, 6.7%, 6% and 5%, 6% by weight percentage of the total, 7.3%, 7.4%, 7.5%, 7.6%, 7.7%, 7.8%, 7.9% or 8%.
Preferably, the content of lecithin (i.e. phosphatidylcholine) in the phospholipid, preferably the phospholipid, of the present invention is more than 40%, preferably the content of lecithin in the phospholipid is more than 50%; preferably, the lecithin content of the phospholipids is greater than 60%.
Specifically, the phospholipid is preferably selected from soybean phospholipid, soybean lecithin, egg yolk phospholipid, egg yolk lecithin or krill oil.
Further, the hydrophilic lipid composition of the present invention may further comprise one or more other functional ingredients, such as but not limited to lutein, lutein ester, coenzyme Q10, carotene, astaxanthin, lycopene, soy isoflavones, plant extracts or propolis. For example, in particular, krill oil having a lipidated astaxanthin content of greater than 500mg/kg may be used as a donor lipid for astaxanthin in the hydrophilic lipid compositions of the present invention.
Further, the hydrophilic lipid compositions of the present invention may also contain taste modifying ingredients, such as, but not limited to, flavorants or essences, sweeteners, such as steviol glycosides, glycyrrhizin, sucralose, and the like.
The hydrophilic lipid composition has excellent hydrophilicity, and can quickly form uniform and stable emulsion in water-based liquid through shaking;
alternatively, the hydrophilic lipid compositions of the present invention, which have excellent hydrophilicity, can rapidly form uniform, stable emulsions upon shaking in water-based liquids containing ethanol.
The water-based liquid comprises water, liquid with the water content of more than 60 percent, or aqueous solution containing ethanol.
The shaking of the mixture in the invention refers to the operation of causing the mixture to rapidly flow, roll or/and collide with the container by vibration, shaking or shaking, and includes the shaking of the mixture by the hand of a user, or the shaking of the mixture by the operation of a machine, such as the operation of a manipulator.
The liquid fat of the present invention includes fatty acids or fats that are liquid at normal temperature and pressure, and preferably includes saturated or unsaturated fatty acids, saturated or unsaturated fats, triglycerides of saturated or unsaturated fatty acids, diglycerides of saturated or unsaturated fatty acids, such as oleic acid, linoleic acid, alpha-linolenic acid, gamma-linolenic acid, medium chain triglycerides, diglycerides, medium chain fatty acids, and the like.
The emulsion is a complex and thermodynamically stable system, especially different fat types or fat-soluble components, because the fat-water distribution and the binding energy state of each component are different, the stability of the whole system is crucial, the multi-component fat emulsion system is easy to have unstable phenomena of fat floating, flocculation or layering and the like, the production method and the process determine the shape and the size of fat globules in the emulsion and whether the micro phenomena of aggregation and the like occur, thereby influencing the instability of fat floating, flocculation or layering and the like of the emulsion on a macroscopic level and influencing the digestive absorption and utilization of the emulsion to human bodies.
However, the emulsifier is disadvantageously mixed with vegetable oil and left for a long time at normal temperature or in an environment slightly lower than the normal temperature, which may cause the grease to become turbid, for example, the phospholipid may precipitate, which may seriously affect the quality of the product. The inventors have studied that this phenomenon occurs because the emulsifier is not easily blended with the vegetable oil, for example, the phospholipid has a freezing point higher than that of the vegetable oil, so that the phospholipid that cannot be blended with the vegetable oil precipitates at a temperature lower than the freezing point thereof, thereby causing the oil to become turbid, or the phospholipid precipitates.
Therefore, the preparation method of the hydrophilic lipid composition is of great importance, and the inventor finds that the emulsifier and the vegetable oil are in a blending and mutual-dissolving state through heating and high-speed mixing, so that the emulsifier and the vegetable oil are uniformly distributed, and are further quickly and accurately cooled, or an oil-gas mixed and dissolved composition is formed, so that the emulsifier molecules can form a colloidal solution of a small-molecule microcrystalline state under a high-dispersion state when the emulsifier molecules are quickly cooled, and a stable blending body of the emulsifier and the vegetable oil is achieved.
Further, the present invention provides a method for preparing the above hydrophilic lipid composition, which comprises:
(1) preparing materials: weighing emulsifier, liquid fat and other fat-soluble substances according to a formula, fixing the volume to the required production, stirring, mixing and dispersing uniformly;
(2) placing the liquid prepared in the step (1) in an emulsifying tank, heating to ensure that the temperature of the liquid is over 45 ℃, stirring for 3-25 min under the condition that the stirring speed is greater than 500r/min, preferably under the condition that the stirring speed is greater than 1000r/min, then rapidly cooling the liquid to be below 25 ℃ within 3-5 min, stopping stirring, and standing; or, putting the liquid prepared in the step (1) into an emulsifying tank, heating to ensure that the temperature of the liquid is over 45 ℃, homogenizing in a homogenizer at the pressure of 20-58 MPa, rapidly cooling the liquid to below 25 ℃ within 3-5 min, and stopping stirring;
(3) filling: and (3) carrying out vacuum degassing on the oily liquid, filling, sealing, packaging and inspecting to obtain the hydrophilic lipid composition.
The hydrophilic lipid composition prepared by the above method of the present invention is generally a transparent oil with a light yellow to deep yellow color. Further, the hydrophilic lipid composition is formulated with a water-based liquid by shaking to form an emulsion.
The affinity and dispersibility of the hydrophilic lipid composition with water-based liquid are crucial, and the inventive oil-gas miscible composition preparation method has good improvement effect on the blending of the emulsifier in the liquid fat and the hydrophilicity of the lipid composition. Further, the present invention provides a second process for preparing a hydrophilic lipid composition, which comprises:
(1) preparing materials: weighing emulsifier, liquid fat and other fat-soluble substances according to a formula, fixing the volume to the required production, stirring, mixing and dispersing uniformly;
(2) placing the liquid prepared in the step (1) in an emulsifying tank, continuously introducing nitrogen into the oily liquid or keeping the pressure in the emulsifying tank to be more than 1.3 atmospheric pressure, and stirring for 3-25 min under the condition that the stirring speed is more than 300r/min to enable the oily liquid to be non-transparent nitrogen-rich foam type oily liquid, and stopping stirring;
(3) filling: filling the oily liquid prepared in the step (2) into a container, filling nitrogen into the container according to needs, enabling the gas pressure in the container to be larger than 1.2 atmospheric pressure, sealing, packaging and inspecting to obtain the hydrophilic lipid composition.
The hydrophilic lipid composition prepared by the method is a foam type oil and fat substance containing nitrogen, is non-transparent, and contains fine and uniform bubbles by visual inspection or is in a foam state in liquid oil and fat. Further, the hydrophilic lipid composition is formulated with a water-based liquid by shaking to form an emulsion.
Further, the present invention provides a method for preparing the hydrophilic lipid composition according to the third aspect, which comprises:
(1) preparing materials: weighing emulsifier, liquid fat and other fat-soluble substances according to the formula for later use;
(2) mixing and stirring the liquid fat and the fat-soluble substances to uniformly mix and disperse the liquid fat and the fat-soluble substances to obtain a mixture of the fat-soluble substances;
(3) premixing of the emulsifier: placing a mixture of an emulsifier and the fat-soluble substances prepared in the step (2) with the weight of the emulsifier being 3-7 times that of the emulsifier in an emulsification tank, continuously introducing nitrogen into the oily liquid or keeping the pressure in the emulsification tank to be higher than 1.3 atmospheric pressure, stirring at a stirring speed of more than 300r/min to enable the oily liquid to be non-transparent nitrogen-rich foam oily liquid or enable the grease to be foam, and stopping stirring;
(4) placing the premixed material of the emulsifier prepared in the step (3) into an emulsifying tank, adding the mixture of the rest fat-soluble substances, continuously introducing nitrogen into the oily liquid or keeping the pressure in the emulsifying tank to be more than 1.3 atmospheric pressure, stirring at the stirring speed of more than 300r/min to enable the oily liquid to be a non-transparent nitrogen-rich foam type grease, and stopping stirring;
(5) filling: and (3) filling the oily liquid prepared in the step (4) into a container, filling nitrogen into the container according to requirements, enabling the gas pressure in the container to be larger than 1.2 atmospheric pressure, sealing, packaging and inspecting to obtain the hydrophilic lipid composition. Further, the hydrophilic lipid composition is formulated with a water-based liquid by shaking to form an emulsion.
In another aspect, the present invention provides a hydrophilic lipid composition comprising an emulsifier and liquid fat, characterized by being prepared by the above-mentioned first preparation method, second preparation method or third preparation method.
Further, the invention provides a foam type hydrophilic lipid composition, which comprises the emulsifier, the fat-soluble substance A, the fat-soluble substance B and nitrogen, wherein the emulsifier is selected from one or more of the following substances: phospholipid, sucrose fatty acid ester, mono-diglycerol fatty acid ester, polyglycerol fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty glyceride, tween 20, tween 40, tween 60, tween 80, span 20, span 40, span 60, span 65 and span 80, wherein the content of the emulsifier is 0.05-8% by weight; the fat-soluble substance A is selected from one or more of the following substances: oleic acid, linoleic acid, linolenic acid, medium-chain triglyceride, diglyceride and medium-long chain fatty acid, wherein the content of the fat-soluble substance A is more than 45 percent in weight ratio; the fat-soluble substance B is selected from one or more of the following substances: nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol ester, phytostanol ester, rice bran fatty alkanol and polyene phosphatidyl choline, wherein the content of the fat-soluble substance B is 0-30% by weight, and preferably the content of the fat-soluble substance B is 0.01-30% by weight; the linolenic acid comprises alpha-linolenic acid or gamma-linolenic acid, the medium-long chain fatty acid comprises medium-chain fatty acid or long-chain fatty acid, the emulsifier also comprises various types, specifications, polymerization degree, esterification degree, mono/diester or monomer components contained in the emulsifier, and the content of lecithin in the phospholipid is more than 40%; preferably the emulsifier is selected from phospholipids and one or more of the following: sucrose fatty acid ester, mono-diglycerol fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty glyceride, tween 20, tween 40, tween 60, tween 80, span 20, span 40, span 60, span 65 and span 80; wherein the content of the emulsifier is 0.1 to 4 percent by weight, preferably 0.2 to 3 percent by weight; the preparation method adopts the second preparation method or the third preparation method.
The inventor surprisingly found that the hydrophilic lipid composition provided by the invention can be quickly formed into an emulsion by shaking in a water-based liquid, for example, the hydrophilic lipid composition and the water-based liquid are mixed in a closed container by shaking, for example, in a beverage bottle closed by a bottle cap, the total volume of the hydrophilic lipid composition and the water-based liquid in the container is not higher than 98% of the total volume of the container, and the emulsion can be instantly formed by shaking vigorously for 1-3 times by hands, and the emulsion is still kept for 5min, even more than 10min, and still keeps a uniform and stable emulsion, thereby being greatly convenient for a consumer or a patient to prepare and eat; in addition, after the hydrophilic lipid composition and the water-based liquid are mixed to form an emulsion, the emulsion can be dispersed into the emulsion even if the emulsion is slightly shaken after being kept still for a long time to be layered, and drinking or eating cannot be influenced. The inventors refer to the process or technique of instantly forming an emulsion of the lipid composition provided by the present invention with a water-based liquid under shaking as "oil-water instant mixing".
It should be noted that the observation of whether the emulsion is stratified or not is based on the occurrence of a state in which the lipid material floats on the surface of the water-based liquid and a clear separation of the lipid material from the water-based liquid occurs; in addition, during observation, attention should be paid to distinguish the nature of the layering of the emulsion from the presence of bubbles or foam on the surface of the emulsion; in general, the present hydrophilic lipid compositions and water-based liquids when shaken to form emulsions will create bubbles or foam of the emulsion, and the bubbles or foam will float on the surface of the emulsion, but the floating bubbles or foam will not cause the emulsion to delaminate, which is a difference.
Further, the present invention provides a method of using a hydrophilic lipid composition comprising an emulsifier and a liquid fat, which comprises adding the hydrophilic lipid composition to a water-based liquid, shaking the mixture to form an emulsion, and further using the emulsion, for example, preferably as a product for nutritional treatment such as a potable blend oil, a potable health oil, etc.;
alternatively, or in addition, the present invention provides a method of using the hydrophilic lipid composition, comprising mixing the hydrophilic lipid composition of the present invention with a water-based liquid, and shaking the mixture in a closed container to form an emulsion;
wherein the water-based liquid comprises water, liquid with water content more than 60%, or water solution containing ethanol; the shaking is preferably performed at a frequency of at least 1 shaking within 1 second and for a time of not less than 1 second.
Further, the present invention provides a method for blending a hydrophilic lipid composition comprising an emulsifier and a liquid fat with a water-based liquid, comprising mixing the lipid composition with the water-based liquid followed by shaking to form an emulsion, wherein the water-based liquid comprises water, a liquid having a water content of greater than 60%, or an aqueous solution comprising ethanol.
In another aspect, the present invention provides a hydrophilic lipid composition comprising an emulsifier and a liquid fat, which has rapid water emulsification properties, and is preferably formulated into an emulsion using a formulation bottle, and in particular, a method for rapidly formulating a hydrophilic lipid composition into an aqueous emulsion using a water-based liquid, which comprises: pouring the hydrophilic lipid composition and the water-based liquid into a mixing bottle, wherein the weight ratio of the water-based liquid to the hydrophilic lipid composition is more than 3:1, preferably the weight ratio of the water-based liquid to the hydrophilic lipid composition is more than 10:1, so that the total volume of the hydrophilic lipid composition and the water-based liquid does not exceed 98% of the capacity of the mixing bottle, screwing the cover of the mixing bottle, shaking the mixing bottle by hands or a mechanical arm for at least 1 time within 1 second, so that the shaking time of the mixing bottle is not more than 10 seconds, particularly the shaking time of the mixing bottle is not more than 5 seconds, when the mixing bottle is shaken, the distance of each displacement of the mixing bottle is not less than 10 centimeters, and the mixing liquid moves to the rest space of the mixing bottle, preferably the mixing liquid moves to the rest space of the mixing bottle and impacts the cover of the mixing bottle, so that a uniform emulsion can be formed, and the emulsion is kept in a uniform emulsion state after, no delamination occurs; the blending bottles comprise glass bottles with covers, plastic bottles with covers, aluminum-plastic paper boxes with covers, metal containers with covers, such as high-molecular PET bottles, high-density polyethylene bottles and the like; preferably the volume of the formulation bottle is not more than 3 liters, most preferably the volume of the formulation bottle is not more than 3 liters, preferably the volume of the formulation bottle is 2.5 liters, 1.5 liters, 1 liter, 0.9 liters, 0.8 liters, 0.7 liters, 0.6 liters, 0.5 liters, 0.45 liters, 0.4 liters, 0.3 liters, 0.2 liters, 0.15 liters, 0.1 liters, 0.09 liters, 0.08 liters, 0.07 liters, 0.06 liters, 0.05 liters or 0.04 liters, etc.; the water-based liquid comprises water, liquid with the water content of more than 60 percent, or aqueous solution containing ethanol.
For example, the water-based liquid of the present invention includes, but is not limited to, water, an aqueous solution of carbohydrate (e.g., monosaccharide, disaccharide, oligosaccharide, polysaccharide, etc.), an aqueous solution of dietary fiber (e.g., inulin, fructooligosaccharide, polydextrose), an aqueous suspension of dietary fiber, an animal emulsion, an animal protein powder emulsion, a vegetable protein emulsion, an aqueous solution or suspension of probiotic bacteria, an aqueous solution of amino acid, an aqueous solution of vitamin, fruit juice, vegetable juice, an aqueous extract of plant, an aqueous solution or aqueous suspension of plant extract (e.g., an aqueous solution of tea or coffee, an aqueous suspension of tea or coffee), an aqueous ethanol solution, a homogenized meal, and the like.
The hydrophilic lipid composition containing the emulsifier and the liquid fat has unexpected rapid water emulsification performance, and brings great convenience and novelty to the use of the composition.
The hydrophilic lipid composition of the present invention can be rapidly or instantaneously dispersed in water by shaking, and has a rapid hydrophilic characteristic. Furthermore, the invention provides a technical scheme for rapidly preparing the hydrophilic lipid composition into emulsion. A hydrophilic lipid composition comprising an emulsifier selected from one or more of the following: phospholipid, sucrose fatty acid ester, mono-diglycerol fatty acid ester, polyglycerol fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty glyceride, tween 20, tween 40, tween 60, tween 80, span 20, span 40, span 60, span 65 and span 80, wherein the content of the emulsifier is 0.05-8% by weight, preferably 0.1-6% by weight; the fat-soluble substance A is selected from one or more of the following substances: oleic acid, linoleic acid, alpha-linolenic acid, gamma-linolenic acid, medium chain triglyceride, diglyceride and medium-long chain fatty acid, wherein the content of the fat-soluble substance A is more than 45 percent in weight ratio; the fat-soluble substance B is selected from one or more of the following substances: nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol ester, phytostanol ester, rice bran fatty alkanol and polyene phosphatidyl choline, wherein the content of fat-soluble substances B is 0-30% by weight, the method is characterized in that an emulsion can be formed within 5 seconds by shaking a hydrophilic lipid composition and a water-based liquid, and the formed emulsion is kept still for at least 1min, can keep a uniform emulsion state and does not generate layering, wherein the weight ratio of the water-based lipid composition to the hydrophilic lipid composition is more than 3:1, and preferably the weight ratio of the water-based lipid composition to the hydrophilic lipid composition is more than 10: 1;
the water-based liquid comprising: water, liquid with water content more than 60%, or water solution containing ethanol;
the shaking refers to the movement of the mixture in the container to generate movement, tumbling or/and collision impact by the operation method of vibration, shaking or sloshing, and includes the shaking of the mixture by the hand of the user, or the shaking of the mixture by the machine operation, for example, the operation of a manipulator.
The velocity of the sloshing, preferably the frequency of at least 1 sloshing within 1 second;
the medium-long chain fatty acid comprises a medium-chain fatty acid or a long-chain fatty acid;
preferably, the content of the fat-soluble substance B is 0.01-30% by weight;
preferably, the method is characterized in that the emulsion is formed by shaking the hydrophilic lipid composition and the water-based liquid within 4 seconds;
preferably, the method is characterized in that the hydrophilic lipid composition and the water-based liquid form an emulsion within 3 seconds by shaking;
preferably, the method is characterized in that the hydrophilic lipid composition and the water-based liquid form an emulsion within 2 seconds by shaking;
preferably, the method is characterized in that the emulsion is formed within 1 second by shaking the hydrophilic lipid composition with the water-based liquid.
The hydrophilic lipid composition belongs to fat-type compositions, and in order to be convenient to use and better to absorb, the hydrophilic lipid composition is necessary to form emulsion in water-based liquid. For example, the present invention provides said hydrophilic lipid composition as a health food or drink partner for various water-based liquid foods, preferably as a homogenized meal, milk, beverage, aqueous solution, fruit juice, coffee, liquid food such as porridge, rice paste, batter, reconstituted food such as reconstituted oatmeal, reconstituted milk powder, reconstituted coffee, reconstituted solid beverage, etc.; preferably used as drinking blend oil and drinkable health oil for water blending; more preferably, the emulsion is prepared from a water-based liquid.
Still further, the present invention provides a packaged composition comprising the hydrophilic lipid composition of the present invention and an aqueous-based liquid, and a method of formulating the packaged composition into an emulsion.
A packaged composition comprising separately packaging and combining a hydrophilic lipid composition with an aqueous-based liquid, said hydrophilic lipid composition comprising a liquid fat and an emulsifier, wherein the liquid fat is selected from one or more of the group consisting of: medium chain triglycerides, alpha-linolenic acid, gamma-linolenic acid, diglycerides, oleic acid, linoleic acid, medium and long chain fatty acids, the content of liquid fat in the hydrophilic lipid composition being more than 45% by weight;
the emulsifier is selected from one or more of the following: phospholipid, sucrose fatty acid ester, mono-diglycerol fatty acid ester, polyglycerol fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty glyceride, tween 20, tween 40, tween 60, tween 80, span 20, span 40, span 60, span 65 and span 80, wherein the content of the emulsifier in the hydrophilic lipid composition is 0.05-8% by weight;
the water-based liquid is selected from water, liquid with the water content of more than 60 percent, or aqueous solution containing ethanol;
the weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 3: 1;
the sum of the volumes of the aqueous-based liquid and the hydrophilic lipid composition is no greater than 98% of the volume of the container holding the aqueous-based liquid.
The above packaged composition, wherein the hydrophilic lipid composition further comprises a fat-soluble substance B, and the fat-soluble substance B is selected from one or more of the following substances: nervonic acid, DHA, EPA, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol ester, phytostanol ester, rice bran fatty alkanol and polyene phosphatidyl choline, wherein the content of the fat-soluble substance B in the hydrophilic lipid composition is 0.01-30% by weight.
In particular, the hydrophilic lipid compositions of the present invention in various combinations, specific ingredients, ratios, methods of preparation, and methods of formulation are all suitable for use in the hydrophilic lipid compositions of the packaged composition described above.
The packaging composition comprises the hydrophilic lipid composition and the water-based liquid which are separately packaged and combined together, such as forming a combined package or a packaging bag, or for example, the separate package of the lipid composition and the separate package of the water-based liquid are combined together in the form of a sticking fixing, a labeling fixing or a packaging kit to form a packaging composition, wherein the "combining together in the form of a sticking fixing, a labeling fixing or a packaging kit" means that the separate package of the lipid composition and the separate package of the water-based liquid are combined together in the form of an adhesive tape or an adhesive glue and the like; or the product label of the lipid composition and the product label of the water-based liquid are used for combining the independent package of the lipid composition and the independent package of the water-based liquid by the acting force of binding, wrapping, winding and the like of the labels; or the lipid composition and the water-based liquid are provided in a package kit, for example, a groove is provided on the container of the water-based liquid, the package of the lipid composition is clamped in the groove to form the package kit, or the lipid composition is sealed in the container in a cavity of a cover member of the container, the water-based liquid is sealed in the container, the cover member of the container is mounted on an opening of the container to seal the container, so that the lipid composition and the water-based liquid are sealed independently, and when in use, the cover member of the container is opened to release the lipid composition in the cover member to be mixed with the water-based liquid in the container, and further, a uniform emulsion is formed by shaking; for example, the lid member of the container may refer to a solution similar to that disclosed in international publication WO 2007/129126.
Or, the packaging composition comprises the hydrophilic lipid composition of the invention which is packaged independently and is in the same packaging box unit with a blending bottle, the blending bottle is an empty bottle with a cover, preferably, a scale mark for marking the amount of the water-based liquid to be added is marked on the blending bottle, when in use, only a package of the hydrophilic lipid composition is required to be opened, the hydrophilic lipid composition is poured into the blending bottle, and then the water-based liquid is added, so that the blending and shaking are convenient, the fatty acid composition can form a uniform emulsion in the water-based liquid for use, and a user can determine the amount of the added hydrophilic lipid composition and the amount of the added water-based liquid by himself/herself.
Alternatively, in the case of the packaged composition of the present invention, the label of the package of the hydrophilic lipid composition may not be provided with a bottle, but the label of the package of the hydrophilic lipid composition is provided with information on the content of an emulsion obtained by mixing the lipid composition with a water-based liquid in a container and shaking the mixture, and the packaged composition of the lipid composition of the present invention, that is, the hydrophilic lipid composition, and the product label thereof is provided with information on the content of an emulsion obtained by mixing the hydrophilic lipid composition with a water-based liquid and shaking the mixture.
The above packaging composition is more convenient for combination and storage of lipid composition and water-based liquid, and is more convenient for use in preparation of lipid composition and water-based liquid, and the method for preparing hydrophilic lipid composition and water-based liquid into emulsion comprises: pouring the hydrophilic lipid composition into a container containing the water-based liquid, wherein the weight ratio of the water-based liquid to the hydrophilic lipid composition is more than 3:1, so that the total volume of the hydrophilic lipid composition and the water-based liquid is not more than 98% of the capacity of the container, screwing down a cover of the container, shaking the mixing bottle by hand or a mechanical hand at a frequency of at least 1 time within 1 second, so that the shaking of the container is not more than 10 seconds, and when the container is shaken, the distance of each displacement of the container is not less than 10 centimeters, and moving the mixed liquid to the residual space of the container to form emulsion, preferably, when the container is shaken, moving the mixed liquid to the residual space of the container and mixing the cover of the bottle;
wherein the hydrophilic lipid composition comprises any one of the hydrophilic lipid compositions of the present invention;
the water-based liquid is selected from water, liquid with the water content of more than 60 percent, or aqueous solution containing ethanol;
the container for the water-based liquid is selected from a glass bottle with a cover, a plastic bottle with a cover, an aluminum-plastic paper box with a cover and a metal container with a cover, and the volume of the container is not more than 3 liters.
The invention also provides the hydrophilic lipid composition which is suitable for medicines, formula foods for special medical application, health-care foods, nutritional foods or cosmetics and the like, on one hand, the hydrophilic lipid composition contains unsaturated fatty acids and fat health components which have the effects of recovering human health and diseases, and is particularly suitable for preparing medicines, formula foods for special medical application, health-care foods, nutritional foods or cosmetics, on the other hand, the hydrophilic lipid composition of the invention is in a liquid state and can be used as an oil solvent to dissolve fat-soluble medicines and further can be prepared and dispersed in water-based liquid to form emulsion for use, so as to be beneficial to oral administration, absorption and utilization of the fat-soluble medicines, for example, the fat-soluble medicines comprise adefovir dipivoxil, tenofovir disoproxil, lutein ester, coenzyme Q10 and the like. In addition, when used in cosmetics, the cosmetic composition is used as an emollient essential oil, a skin care essential oil, a hair care essential oil, or a water-soluble cosmetic composition for moisturizing and moisturizing the face and skin, and a skin nourishing oil emulsion, etc., for caring and beautifying the skin, etc. In particular, the hydrophilic lipid composition of the invention is used as a product for health care and nutrition treatment such as drinking blend oil and drinking healthy oil. In particular to the application in preparing homogenate diet of formula food with special medical application.
Therefore, the invention also provides the application of the hydrophilic lipid composition containing the emulsifier and the liquid fat to the preparation or preparation of medicaments, special medical purpose formula foods, health foods, nutritional foods or cosmetics by mixing the hydrophilic lipid composition with water-based liquid and further shaking the hydrophilic lipid composition into emulsion, particularly the application to the preparation or preparation of medicaments, special medical purpose formula foods, health foods and nutritional foods which are taken orally immediately or the application to the preparation or preparation of cosmetics which are used immediately, which is greatly convenient for users to prepare and use immediately.
The invention also provides the use of a hydrophilic lipid composition comprising an emulsifier and liquid fat to prepare an emulsion by mixing with a water-based liquid and shaking.
The invention also provides the application of the hydrophilic lipid composition containing the emulsifier and the liquid fat in preparing the homogenate diet of the formula food with special medical application by mixing the hydrophilic lipid composition with the water-based liquid and further shaking to prepare emulsion.
The invention also provides an emulsion prepared by mixing the hydrophilic lipid composition containing the emulsifier and the liquid fat with the water-based liquid and shaking, and further applied to the preparation of food, wherein the emulsion is used for replacing water in the preparation of food and is applied to the preparation of food, including but not limited to the preparation of steamed food, cooked food, prepared flour food, various mixed foods or brewed food and beverage.
In one aspect, the hydrophilic lipid compositions of the present invention provide unsaturated fatty acids, such as nervonic acid, alpha-linolenic acid, gamma-linolenic acid, DHA, EPA, arachidonic acid, and the like, and lipid soluble drugs or nutrients, such as vitamin E, medium chain triglycerides, phospholipids, vitamin a, vitamin D, lutein esters, coenzyme Q10, and the like, that are beneficial for human health and disease treatment; on the other hand, the emulsifier and the fat-soluble substances have good pharmacological synergistic effect, and have good synergistic effect on human health, particularly on the aspect of oral supplement of phospholipid, unsaturated fatty acid, fat-soluble medicines and the like. Therefore, in a further aspect, the present invention provides the use of a hydrophilic lipid composition comprising an emulsifier and liquid fat, mixed with a water-based liquid and shaken to prepare an orally ingestible emulsion for the preparation of a medicament or a special food for the prevention and treatment of cardiovascular and cerebrovascular diseases; the application in preparing medicines or special foods for nourishing or protecting cranial nerves; the application in preparing the medicine for preventing and treating the neurodegenerative diseases; the application in the preparation of medicines for reducing the risk of myocardial infarction, cerebral apoplexy or cardiovascular diseases; the application in preparing medicines for improving myocardial ischemia and cerebral ischemia, protecting heart and brain cells, reducing blood lipid, preventing and treating cardiovascular and cerebrovascular diseases, and protecting heart and cerebral vessels; the application in the preparation of the medicine or the special food for treating the fatty liver; the application in preparing weight-reducing medicines or special foods; the application in preparing anti-fatigue drugs or special foods; the use in the manufacture of a medicament or a specific food product for providing unsaturated fatty acids; or the use in the manufacture of a medicament or a specific food product providing fat solubility.
The hydrophilic lipid composition can also be used in the preparation of meals, and in any meals which need to be prepared or blended by water, the emulsion prepared by the hydrophilic lipid composition and the water can be used for replacing the application of the water in the preparation of meals, so that the prepared meals not only supplement fatty acid and liquid fat which are necessary for human bodies, moreover, the prepared meal has appropriate light and thick oil fragrance, is favorable for improving appetite, and more importantly, the process of preparing the meal, on one hand, the method is fun for consumers, and particularly, the oil-based substances and the water-based substances are instantly changed into emulsion through the shaking process of one or two seconds, so that the drinking or eating desire of the consumers is greatly improved, this process of self-adjusting the diet, creates a psychological desire to aid in the intake of the healthy nutritional oil-based substances of the present invention; on the other hand, the process of blending the hydrophilic lipid composition with water is a process of making a meal maker feel handy, brain-arouse and use eyes, and particularly, the oil-based substance and the water-based substance are instantly changed into emulsion through the shaking process of one or two seconds, so that the drinking or eating desire of consumers is greatly improved, and the psychological desire generated in the process of self-blending the meal is favorable for the intake of the healthy and nutritional oil-based substance; in addition, the pressure is released in the shaking (vibrating and shaking) process, a pleasant mood is brought in the process, the eating mood is optimized, the pleasant mood state is favorable for eating health, the healthy and nutritional oil-based substance disclosed by the invention can be used for exerting the effect, the eating quantity of the beverage or the homogenate meal can be increased, the drinking abandon rate is reduced, and the waste and the pollution are reduced.
The hydrophilic lipid composition provided by the invention realizes a product blending mode of rapid oil-water blending, and has great significance. For the beverage or homogenate meal, the oil-based substance and the water-based substance are respectively and independently packaged and combined together, and are quickly mixed to form emulsion in a shaking and blending mode when in use.
In a further health sense, the hydrophilic lipid composition provided by the invention can not only bring more healthy fat to consumers, such as medium-chain triglyceride, omega-3 fatty acid, omega-6 fatty acid, phospholipid, arachidonic acid, vitamin E, vitamin A, vitamin D, conjugated linoleic acid, phytosterol and other substances in health, nutrition and disease prevention and treatment categories, such as cardiovascular and cerebrovascular protection, intelligence improvement and nutritional nerves; but also makes the consumers obtain the substances which are beneficial to the health and the disease prevention and treatment in the way of beverage, homogenate meal and common meal more easily and conveniently.
Conceivably, the hydrophilic lipid composition provided by the invention is beneficial to improving the existing dietary habits of people, and even beneficial to improving the food making habits and food collocation ideas of human beings.
It should be understood that the oral preparation needs to be absorbed from the gastrointestinal tract to enter the blood of human body to achieve physiological effect, and the quality of oral absorption directly affects the therapeutic effect of the medicine. Bioavailability (Bioavailability) refers to the degree and rate of utilization of a formulation as it is absorbed into the blood circulation, in terms of the concept of pharmacy.
Compared with other non-emulsion preparations, the invention contains the emulsifier and the fat-soluble substances, quickly forms an emulsion in water-based liquid, has excellent water-oil solubility, has obvious promotion effect and significance on the degree and speed of the oral preparation taking the fat-soluble substances as active ingredients in absorbing and entering blood circulation, and has important significance on the improvement of the bioavailability of the fat-soluble substances. The preparation is absorbed after entering the stomach and intestine, and is divided into two stages, namely a dispersion stage and a gastrointestinal wall absorption stage, wherein the two stages are firstly dispersed in gastric juice or intestinal juice and then contacted with and attached to the gastrointestinal wall for absorption and enter the blood, the two stages can influence the absorption and utilization of unsaturated fatty acid and fat-soluble substances with other health functions and the exertion of health functions, the fat-soluble substances are prepared into an emulsion with good water dispersibility, the dissolution and dispersion speeds of the fat-soluble substances are obviously accelerated, the dispersion degree and the dispersion speed of the fat-soluble substances in the gastric juice or the intestinal juice are greatly improved, the contact between the fat-soluble substances and the gastrointestinal wall is more sufficient, the active ingredients attached to the gastrointestinal wall for absorption and enter the blood are also more sufficient, and the preparation has important significance for improving the bioavailability of the fat-soluble substances. For example, nervonic acid, DHA, EPA, phosphatidylserine, medium chain triglyceride, alpha-linolenic acid, gamma-linolenic acid and the like are blended into emulsion by the hydrophilic lipid composition provided by the invention and water-based liquid, so that the Bioavailability (Bioavailability) of the emulsion is obviously improved and the effect is very obvious.
The hydrophilic lipid composition and the preparation method thereof solve the defects of the prior art and have the following advantages: 1. the grease component contains no water and has good stability; 2. the water-soluble starch has excellent hydrophilicity, can be mixed with water and dispersed to form emulsion, is beneficial to eating and convenient to operate; 3. the blending is convenient and quick, and uniform emulsion can be formed in 1-5 seconds by shaking in the container, so that pleasant mood is brought to diet blending or making, pressure release and diet health are facilitated, and diet mood is optimized; 4. improving the bioavailability of the functional fatty acid or the fat-soluble substance; 5. the formed emulsion has better stability, and can keep uniform and stable emulsion after standing for more than 5 min; 6. the formed emulsion can still form uniform emulsion after being layered after being placed for a long time and being slightly shaken, and is beneficial to the discontinuous drinking or oral intake of a user.
Detailed description of the inventionin the practice of the present invention, various embodiments and modifications will be apparent to and can be readily made by those of ordinary skill in the art without departing from the scope and spirit of the invention. The following examples are intended to further specifically illustrate the application and the like of the present invention, but are not intended to limit the present invention.
Example 1 hydrophilic lipid compositions, methods of preparation and formulation thereof, combinations thereof.
A hydrophilic lipid composition, the formulated amounts comprising, in weight percent:
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wherein the phospholipid is selected from soybean phospholipid, soybean lecithin, egg yolk phospholipid, egg yolk lecithin or krill oil.
The preparation method comprises the following steps:
(1) preparing materials: weighing emulsifier, liquid fat and other fat-soluble substances according to the formula, fixing the volume to the required production, stirring, mixing and dispersing uniformly, or adding other fat-soluble substances such as nervonic acid, DHA, arachidonic acid, phytosterol ester or phosphatidylserine into the liquid fat to completely dissolve the liquid fat, adding the emulsifier, stirring, mixing and dispersing uniformly;
(2) putting the liquid prepared in the step (1) into an emulsifying tank, heating to ensure that the temperature of the liquid is over 45 ℃, stirring for 3-25 min under the condition that the stirring speed is more than 500r/min, then rapidly cooling the liquid to be below 25 ℃ within 3-5 min, stopping stirring, and standing; or, putting the liquid prepared in the step (1) into an emulsifying tank, heating to ensure that the temperature of the liquid is over 45 ℃, homogenizing in a homogenizer at the pressure of 20-58 MPa, rapidly cooling the liquid to below 25 ℃ within 3-5 min, and stopping stirring;
(3) filling: vacuum degassing the oily liquid, bottling, sealing, packaging, and inspecting.
Or the preparation method II comprises the following steps:
(1) preparing materials: weighing emulsifier, liquid fat and other fat-soluble substances according to the formula, fixing the volume to the required production, stirring, mixing and dispersing uniformly, or adding other fat-soluble substances such as nervonic acid, DHA, arachidonic acid, phytosterol ester or phosphatidylserine into the liquid fat to completely dissolve the liquid fat, adding the emulsifier, stirring, mixing and dispersing uniformly;
(2) placing the liquid prepared in the step (1) in an emulsifying tank, continuously introducing nitrogen into the oily liquid or keeping the pressure in the emulsifying tank to be more than 1.3 atmospheric pressure, and stirring for 3-25 min under the condition that the stirring speed is more than 300r/min to enable the oily liquid to be a non-transparent nitrogen-rich foam type oil substance, and stopping stirring;
(3) filling: filling the oily liquid prepared in the step (2) into a container, further filling nitrogen into the container, enabling the gas pressure in the container to be larger than 1.2 atmospheric pressure, sealing, packaging and inspecting to obtain the liquid.
Or, the third preparation method comprises the following steps:
(1) preparing materials: weighing emulsifier, liquid fat and other fat-soluble substances according to the formula for later use;
(2) mixing liquid fat and fat-soluble substances, stirring, and uniformly mixing and dispersing to obtain mixture of fat-soluble substances, or adding other fat-soluble substances such as nervonic acid, DHA, arachidonic acid, phytosterol ester or phosphatidylserine into liquid fat and completely dissolving in liquid fat, stirring, mixing, and uniformly dispersing;
(3) premixing of the emulsifier: placing a mixture of an emulsifier and the fat-soluble substances prepared in the step (2) with the weight of the emulsifier being 3-7 times that of the emulsifier in an emulsification tank, continuously introducing nitrogen into the oily liquid or keeping the pressure in the emulsification tank to be higher than 1.3 atmospheric pressure, stirring at a stirring speed of more than 300r/min to enable the oily liquid to be a non-transparent nitrogen-rich foam type grease or to enable the grease to be foam, and stopping stirring;
(4) placing the premixed material of the emulsifier prepared in the step (3) into an emulsifying tank, adding the mixture of the rest fat-soluble substances, continuously introducing nitrogen into the oily liquid or keeping the pressure in the emulsifying tank to be more than 1.3 atmospheric pressure, stirring at the stirring speed of more than 300r/min to enable the oily liquid to be a non-transparent nitrogen-rich foam type grease, and stopping stirring;
(5) filling: and (3) filling the oily liquid prepared in the step (4) into a container, further filling nitrogen into the container, enabling the gas pressure in the container to be larger than 1.2 atmospheric pressure, sealing, packaging and inspecting to obtain the liquid.
Fast blending performance: pouring the hydrophilic lipid composition and the water-based liquid in any ratio in the embodiment into a mixing bottle, wherein the weight ratio of the water-based liquid to the hydrophilic lipid composition is more than 10:1, so that the total volume of the hydrophilic lipid composition and the water-based liquid is not more than 98% of the capacity of the mixing bottle, screwing the cover of the mixing bottle, shaking the mixing bottle by hands or a mechanical hand for at least 1 time within 1 second, shaking the mixing bottle for at most 5 seconds, wherein when the mixing bottle shakes, the displacement distance of the mixing bottle is not less than 10 cm, and the mixed liquid moves to the rest space of the mixing bottle, preferably moves to the rest space of the mixing bottle and impacts the cover of the mixing bottle, so that a uniform emulsion can be formed, and the emulsion still presents a uniform emulsion after standing for 5min at room temperature without layering; the blending bottle is a glass bottle with a cover, a plastic bottle with a cover, an aluminum-plastic paper box with a cover, a metal container with a cover, such as a high polymer PET bottle, a high density polyethylene bottle and the like; the cap is provided to enable the cap to be tightened for shake dispensing operations, preferably the bottle has a volume of no more than 3 liters, for example, preferably the bottle has a volume of 0.5 liter, and the aqueous based liquid includes water, a liquid having a water content of greater than 60%, or an aqueous solution containing ethanol, for example, including but not limited to animal milk, fruit juice, fruit and vegetable drink, plant extract or drink, carbohydrate solution, vegetable protein drink, aqueous emulsion of animal milk powder, aqueous solution of amino acids, and the like.
Example 2, hydrophilic lipid compositions, methods of making and formulating the same.
A hydrophilic lipid composition, the formulated amounts comprising, in weight percent:
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wherein the phospholipid is selected from soybean phospholipid, soybean lecithin, egg yolk phospholipid, egg yolk lecithin or krill oil; the donor vegetable oil of alpha-linolenic acid is selected from linseed oil, perilla seed oil, pumpkin seed oil, peony seed oil, eucommia seed oil or calamus oil; the donor oil of gamma-linolenic acid is selected from gamma-linolenic acid grease; the donor vegetable oil of linoleic acid is selected from soybean oil, corn oil, peanut oil, sunflower seed oil, olive oil, silybum marianum seed oil, pumpkin seed oil, almond oil, palm oil, sesame oil, walnut kernel oil, rapeseed oil, safflower seed oil, grape seed oil, suaeda salsa seed oil, wheat germ oil, corn germ oil, cornus wilsoniana fruit oil, rhus chinensis fruit oil, sambucus chinensis fruit oil, peony seed oil, samara oil, corn millet oil, tomato seed oil, zanthoxylum bungeanum seed oil, mustard seed oil, tea oil (including tea seed oil, camellia seed oil or tea tree oil), rice bran oil, shea butter, borage oil, capsicum seed oil, coconut oil or cottonseed oil; the vegetable oil for supplying oleic acid is selected from soybean oil, corn oil, peanut oil, sunflower seed oil, olive oil, pumpkin seed oil, silybum marianum seed oil, almond oil, palm oil, sesame oil, walnut kernel oil, rapeseed oil, safflower seed oil, grape seed oil, rice bran oil, capsicum seed oil, pomegranate seed oil, brucea javanica oil or coconut oil; the nervonic acid donor animal and vegetable oil comprises Acer Truncatum Bunge seed oil or shark oil; the DHA-providing animal and vegetable oil comprises DHA algae oil, krill oil, fish oil or fish oil extract; the EPA donor animal or vegetable oil comprises krill oil, fish oil or fish oil extract.
The preparation method comprises the following steps: the preparation method is the same as the first preparation method, the second preparation method or the third preparation method in example 1, and the preparation method in example 1 can be completely applied to this example.
Blending: the hydrophilic lipid composition in any proportion is mixed with water-based liquid by shaking to prepare emulsion.
Example 3 hydrophilic lipid compositions, methods of making and formulating the same.
A hydrophilic lipid composition, the formulated amounts comprising, in weight percent:
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wherein the phospholipid comprises soybean phospholipid, soybean lecithin, egg yolk phospholipid, egg yolk lecithin or krill oil; the linoleic acid donor vegetable oil is selected from soybean oil, corn oil, peanut oil, sunflower seed oil, olive oil, silybum marianum seed oil, pumpkin seed oil, almond oil, palm oil, sesame oil, walnut kernel oil, rapeseed oil, safflower seed oil, grape seed oil, suaeda salsa seed oil, wheat germ oil, corn germ oil, cornus wilsoniana seed oil, rhus chinensis fruit oil, peony seed oil, samara oil, rice oil, tomato seed oil, zanthoxylum seed oil, mustard seed oil, tea oil (including tea seed oil, camellia seed oil or tea tree oil), rice bran oil, capsicum seed oil, pomegranate seed oil, brucea javanica oil or coconut oil; the vegetable oil for supplying oleic acid is selected from soybean oil, corn oil, peanut oil, sunflower seed oil, olive oil, pumpkin seed oil, silybum marianum seed oil, almond oil, palm oil, sesame oil, walnut kernel oil, rapeseed oil, safflower seed oil, grape seed oil, rice bran oil, capsicum seed oil or coconut oil.
The preparation method comprises the following steps: the preparation method is the same as the first preparation method, the second preparation method or the third preparation method in example 1, and the preparation method in example 1 can be completely applied to this example.
Blending: the hydrophilic lipid composition in any proportion is mixed with water-based liquid by shaking to prepare emulsion.
Example 4 hydrophilic lipid compositions, methods of making and formulating the same.
A hydrophilic lipid composition, the formulated amounts comprising, in weight percent:
Figure 332557DEST_PATH_IMAGE046
Figure 215063DEST_PATH_IMAGE048
Figure 629863DEST_PATH_IMAGE050
Figure 572412DEST_PATH_IMAGE052
Figure 336579DEST_PATH_IMAGE054
Figure 757196DEST_PATH_IMAGE056
wherein the phospholipid is selected from soybean phospholipid, soybean lecithin, egg yolk phospholipid, egg yolk lecithin or krill oil; the donor vegetable oil of alpha-linolenic acid comprises linseed oil, perilla seed oil, pumpkin seed oil, peony seed oil, eucommia seed oil or mei teng fruit oil; the donor oil of gamma-linolenic acid is selected from gamma-linolenic acid grease; the linoleic acid donor vegetable oil is selected from soybean oil, corn oil, peanut oil, sunflower seed oil, olive oil, silybum marianum seed oil, pumpkin seed oil, almond oil, palm oil, sesame oil, walnut kernel oil, rapeseed oil, safflower seed oil, grape seed oil, suaeda salsa seed oil, wheat germ oil, corn germ oil, cornus wilsoniana seed oil, rhus chinensis fruit oil, peony seed oil, samara oil, rice oil, tomato seed oil, zanthoxylum seed oil, mustard seed oil, tea oil (including tea seed oil, camellia seed oil or tea tree oil), rice bran oil, capsicum seed oil, pomegranate seed oil, brucea javanica oil or coconut oil; the vegetable oil for supplying oleic acid is selected from soybean oil, corn oil, peanut oil, sunflower seed oil, olive oil, pumpkin seed oil, silybum marianum seed oil, almond oil, palm oil, sesame oil, walnut kernel oil, rapeseed oil, safflower seed oil, grape seed oil, rice bran oil, capsicum seed oil or coconut oil.
The preparation method comprises the following steps: the preparation method is the same as the first preparation method, the second preparation method or the third preparation method in example 1, and the preparation method in example 1 can be completely applied to this example.
Blending: the hydrophilic lipid composition in any proportion is mixed with water-based liquid by shaking to prepare emulsion.
The hydrophilic lipid compositions of example 5, example 2 to example 4 have fast formulation properties and packaging combinations.
The hydrophilic lipid composition prepared in any one of the ratios of the embodiment 2 to the embodiment 4 has good rapid preparation performance.
Fast blending performance: pouring the hydrophilic lipid composition and the water-based liquid in any ratio in the embodiments into a mixing bottle, wherein the weight ratio of the water-based liquid to the hydrophilic lipid composition is more than 3:1, preferably the weight ratio of the water-based liquid to the hydrophilic lipid composition is more than 10:1, so that the total volume of the hydrophilic lipid composition and the water-based liquid does not exceed 50% of the capacity of the mixing bottle, screwing the cover of the mixing bottle, shaking the mixing bottle by hands or a mechanical arm for at least 1 time within 1 second, shaking the mixing bottle for at most 5 seconds, wherein the displacement distance of the mixing bottle is not less than 10 cm when the mixing bottle is shaken, moving the mixed liquid to the rest space of the mixing bottle, preferably moving the mixed liquid to the rest space of the mixing bottle and impacting the cover of the mixing bottle, and forming a uniform emulsion which still presents a uniform emulsion after standing for 5min at room temperature according to the method, no delamination occurs; the blending bottle is a glass bottle with a cover, a plastic bottle with a cover, an aluminum-plastic paper box with a cover, a metal container with a cover, such as a high polymer PET bottle, a high density polyethylene bottle and the like; the cap is provided to enable the cap to be tightened for shake dispensing operations, preferably the bottle has a volume of no more than 3 liters, for example, preferably the bottle has a volume of 0.5 liter, and the aqueous-based liquid includes water, a liquid having a water content of greater than 60%, or an aqueous solution containing ethanol, for example, including but not limited to animal milk, fruit juice, fruit and vegetable drink, plant extract or drink, carbohydrate solution or drink, vegetable protein drink, aqueous emulsion of animal milk powder, aqueous solution of amino acids, and the like.
Packaging and combining: a packaged composition comprises independently packaging the hydrophilic lipid composition in any ratio in the examples, and storing in the same package box or bag together with a preparation bottle, wherein the preparation bottle is an empty bottle with a cover; or the mixing bottle is pre-filled with a certain volume of water-based liquid which is used for directly adding the fatty acid composition into the mixing bottle and forming uniform emulsion by shaking; or in the packaging composition, the independent package of the hydrophilic lipid composition and the preparation bottle are simultaneously present in one packaging box or packaging bag, or a combined package is formed by sticking and fixing and label fixing, or a packaging bottle or packaging bag containing the hydrophilic lipid composition and the preparation bottle are fixed together in the form of a packaging kit, or the packaging composition contains the hydrophilic lipid composition in any one of the proportions in the embodiment, and the content of emulsion is obtained by shaking the hydrophilic lipid composition and the water-based liquid on the label. Wherein the sum of the volumes of the aqueous-based liquid and the hydrophilic lipid composition is no greater than 98% of the volume of the container or the dispensing bottle containing the aqueous-based liquid.
Packaging and combining: independently sealing the hydrophilic lipid composition in any one of the embodiments in the cavity of the cover member of the container, sealing the water-based liquid in the container, and mounting the cover member of the container at the opening of the container to seal the container, so that the lipid composition and the water-based liquid are independently sealed, and in use, opening the cover member of the container to release the lipid composition in the cover member to be mixed with the water-based liquid in the container, and further, forming a uniform emulsion by shaking;
alternatively, the lipid composition in the chamber of the cap member of the container is injected into the water-based liquid in the form of a liquid column having a diameter of 0.4mm to 2mm, for example, by injecting the lipid composition by high-pressure gas in the chamber of the cap member of the container, or by injecting the lipid composition by piston pressurization or injection, and the lipid composition is mixed with the water-based liquid, shaken and stirred to form an emulsion, wherein the water-based liquid comprises water, a liquid having a water content of more than 60%, or an aqueous solution containing ethanol. Wherein the sum of the volumes of the aqueous-based liquid and the hydrophilic lipid composition is no greater than 98% of the volume of the container holding the aqueous-based liquid.
Example 6, any one of the hydrophilic lipid compositions of examples 1 to 4, taking 1 g of the hydrophilic lipid composition, adding 2 to 150 ml of water-based liquid, shaking the mixture, forming an emulsion within 5 seconds, even within 1 second, and standing the formed emulsion at room temperature for more than 5min, wherein the formed emulsion can be kept stably, can be kept uniform and stable, and does not generate a layering phenomenon;
or pouring the hydrophilic lipid composition and the water-based liquid into a mixing bottle, wherein the weight ratio of water or the water-based liquid with the water content of more than 60 percent to the hydrophilic lipid composition is more than 3:1, preferably the weight ratio of the water-based liquid to the hydrophilic lipid composition is more than 10:1, so that the total volume of the hydrophilic lipid composition and the water-based liquid does not exceed 70 percent of the capacity of the mixing bottle, screwing the cover of the mixing bottle, shaking the mixing bottle by hands or a mechanical arm for at least 2 times within 1 second, shaking the mixing bottle for at most 5 seconds, moving the distance of each displacement of the mixing bottle for not less than 10 centimeters when the mixing bottle is shaken, moving the mixed liquid to the rest space of the mixing bottle, preferably moving the mixed liquid to the rest space of the mixing bottle and impacting the cover of the mixing bottle, and forming uniform emulsion after the above method, the emulsion still presents uniform emulsion after standing for 5 minutes at room temperature, no delamination occurs; the blending bottle can be a glass bottle with a cover, a plastic bottle with a cover, an aluminum-plastic paper box with a cover and a metal container with a cover.
Example 7, example 1-4 any one of the ratio of emulsifier and liquid fat containing hydrophilic lipid composition through with water based liquid mixture, and further through shaking and concocting into emulsion, preparation or blending drugs, special medical uses formula food, health food, nutrition food or cosmetics in the aspect of application.

Claims (4)

1. A packaged composition comprising separately packaging and combining a hydrophilic lipid composition with an aqueous-based liquid, said hydrophilic lipid composition comprising a liquid fat and an emulsifier, wherein the liquid fat is selected from one or more of the group consisting of: medium chain triglycerides, alpha-linolenic acid, gamma-linolenic acid, diglycerides, oleic acid, linoleic acid, medium and long chain fatty acids, the content of liquid fat in the hydrophilic lipid composition being more than 45% by weight;
the emulsifier is selected from one or more of the following: phospholipid, sucrose fatty acid ester, mono-diglycerol fatty acid ester, polyglycerol fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty glyceride, tween 20, tween 40, tween 60, tween 80, span 20, span 40, span 60, span 65 and span 80, wherein the content of the emulsifier in the hydrophilic lipid composition is 0.05-8% by weight;
the water-based liquid is selected from water, liquid with the water content of more than 60 percent, or aqueous solution containing ethanol;
the weight ratio of the water-based liquid to the hydrophilic lipid composition is greater than 3: 1;
the sum of the volumes of the aqueous-based liquid and the hydrophilic lipid composition is no greater than 98% of the volume of the container holding the aqueous-based liquid;
the hydrophilic lipid composition is prepared by a process comprising:
(1) preparing materials: weighing emulsifier, liquid fat and other fat-soluble substances according to the formula, fixing the volume to the required production, stirring, mixing and dispersing uniformly;
(2) putting the liquid prepared in the step (1) into an emulsifying tank, heating to ensure that the temperature of the liquid is over 45 ℃, stirring for 3-25 min under the condition that the stirring speed is more than 500r/min, then rapidly cooling the liquid to be below 25 ℃ within 3-5 min, stopping stirring, and standing; or, putting the liquid prepared in the step (1) into an emulsifying tank, heating to ensure that the temperature of the liquid is over 45 ℃, homogenizing in a homogenizer at the pressure of 20-58 MPa, rapidly cooling the liquid to below 25 ℃ within 3-5 min, and stopping stirring;
(3) filling: vacuum degassing the oily liquid, bottling, sealing, packaging, and inspecting.
2. The packaged composition of claim 1, wherein said hydrophilic lipid composition is prepared instead by a process comprising:
(1) preparing materials: weighing emulsifier, liquid fat and other fat-soluble substances according to the formula, fixing the volume to the required production, stirring, mixing and dispersing uniformly;
(2) placing the liquid prepared in the step (1) in an emulsifying tank, continuously introducing nitrogen into the oily liquid or keeping the pressure in the emulsifying tank to be more than 1.3 atmospheric pressure, and stirring for 3-25 min under the condition that the stirring speed is more than 300r/min to enable the oily liquid to be non-transparent nitrogen-rich foam type oily liquid, and stopping stirring;
(3) filling: filling the oily liquid prepared in the step (2) into a container, further filling nitrogen into the container, enabling the gas pressure in the container to be larger than 1.2 atmospheric pressure, sealing, packaging and inspecting to obtain the liquid.
3. A method of formulating a hydrophilic lipid composition comprising a liquid fat and an emulsifier as an emulsion with a water-based liquid comprising: pouring the hydrophilic lipid composition and the water-based liquid into a mixing bottle, wherein the weight ratio of the water-based liquid to the hydrophilic lipid composition is more than 3:1, so that the total volume of the hydrophilic lipid composition and the water-based liquid is not more than 98% of the capacity of the mixing bottle, screwing the cover of the mixing bottle, shaking the mixing bottle for at least 1 time within 1 second by hands or a mechanical arm, so that the shaking of the mixing bottle is not more than 10 seconds, and when the mixing bottle is shaken, the displacement distance of the mixing bottle is not less than 10 cm, and the mixed liquid moves to the residual space of the mixing bottle to form emulsion;
the emulsifier is selected from one or more of the following substances: phospholipid, sucrose fatty acid ester, mono-diglycerol fatty acid ester, polyglycerol fatty acid ester, propylene glycol fatty acid ester, lactic acid fatty glyceride, tween 20, tween 40, tween 60, tween 80, span 20, span 40, span 60, span 65 and span 80, wherein the content of the emulsifier in the hydrophilic lipid composition is 0.05-8% by weight;
the liquid fat is selected from one or more of the following: oleic acid, linoleic acid, alpha-linolenic acid, gamma-linolenic acid, medium chain triglycerides, diglycerides, medium-long chain fatty acids, the content of said liquid fat in the hydrophilic lipid composition being greater than 45% by weight;
the water-based liquid is selected from water, liquid with the water content of more than 60 percent, or aqueous solution containing ethanol;
the mixing bottle is selected from a glass bottle with a cover, a plastic bottle with a cover, an aluminum-plastic paper box with a cover and a metal container with a cover, and the volume of the mixing bottle is not more than 3 liters;
the hydrophilic lipid composition is prepared by a method comprising:
(1) preparing materials: weighing emulsifier, liquid fat and fat-soluble substances according to a formula, fixing the volume to the required production, stirring, mixing and uniformly dispersing;
(2) putting the liquid prepared in the step (1) into an emulsifying tank, heating to ensure that the temperature of the liquid is over 45 ℃, stirring for 3-25 min under the condition that the stirring speed is more than 500r/min, then rapidly cooling the liquid to be below 25 ℃ within 3-5 min, stopping stirring, and standing; or, putting the liquid prepared in the step (1) into an emulsifying tank, heating to ensure that the temperature of the liquid is over 45 ℃, homogenizing in a homogenizer at the pressure of 20-58 MPa, rapidly cooling the liquid to below 25 ℃ within 3-5 min, and stopping stirring;
(3) filling: vacuum degassing the oily liquid, bottling, sealing, packaging, and inspecting.
4. The method of claim 3 wherein the hydrophilic lipid composition is formulated as an emulsion with a water-based liquid by replacing the hydrophilic lipid composition with a composition prepared by a method comprising:
(1) preparing materials: weighing emulsifier, liquid fat and fat-soluble substances according to a formula, fixing the volume to the required production, stirring, mixing and uniformly dispersing;
(2) placing the liquid prepared in the step (1) in an emulsifying tank, continuously introducing nitrogen into the oily liquid or keeping the pressure in the emulsifying tank to be more than 1.3 atmospheric pressure, and stirring for 3-25 min under the condition that the stirring speed is more than 300r/min to enable the oily liquid to be non-transparent nitrogen-rich foam type oily liquid, and stopping stirring;
(3) filling: filling the oily liquid prepared in the step (2) into a container, further filling nitrogen into the container, enabling the gas pressure in the container to be larger than 1.2 atmospheric pressure, sealing, packaging and inspecting to obtain the liquid.
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