CN104397702A - Lecithin-containing aqueous emulsifying agent as well as preparation method and application thereof - Google Patents
Lecithin-containing aqueous emulsifying agent as well as preparation method and application thereof Download PDFInfo
- Publication number
- CN104397702A CN104397702A CN201410754526.9A CN201410754526A CN104397702A CN 104397702 A CN104397702 A CN 104397702A CN 201410754526 A CN201410754526 A CN 201410754526A CN 104397702 A CN104397702 A CN 104397702A
- Authority
- CN
- China
- Prior art keywords
- emulsion
- purified water
- lecithin
- cla
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000787 lecithin Substances 0.000 title claims abstract description 196
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- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J7/00—Phosphatide compositions for foodstuffs, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
- A23L33/11—Plant sterols or derivatives thereof, e.g. phytosterols
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention provides an emulsion composition containing lecithin, other liposoluble substances and water. The water content of the emulsion composition in percent by weight is larger than 70%; the other liposoluble substances comprise one or more of arachidonic acid, linolenic acid, linoleic acid, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, polyene phosphatidyl choline, phosphatidyl ethanolamine, phosphatidylinositol, phosphatidyl glycerol, phytosterol, phytosterol ester, plant stanol ester and medium-long-chain fatty acid. The preparation method of the emulsion composition comprises the steps of mixing and emulsifying the lecithin and the other liposoluble substances with the water to obtain the emulsion composition, wherein the water content of the emulsion composition in percent by weight is larger than 70%, and the particle sizes of fat globules in the emulsion are smaller than 5 micrometers. Furthermore, the invention provides a preparation method of the emulsion composition and the application of the emulsion composition in oral phosphatide and unsaturated fatty acid replenishers and protection of heart and cerebral vessels.
Description
Technical field
The present invention relates to a kind of healthy product composition, specifically containing the aqua type fuel-water emulsion of lecithin, and preparation method thereof with its application.
Healthy product composition of the present invention, refers to medicine, medical food, health food, nutraceutical or cosmetics etc.
Background technology
The common name phosphatid ylcholine of lecithin, be described as " the 3rd nutrient " arranged side by side with protein, vitamin, since last century the nineties, phosphatide research has achieved significant effect in life science and brain science field, lecithin has good effect to the nutrition of human body with healthy, show: 1, human nutrition needs: the exogenous choline 90% of needed by human body is provided by lecithin, lecithin provides choline to have two large benefits: one, can be degraded into methylamine because of microbial action in enteron aisle unlike free choline; Secondly, it is the acquisition choline that methylates continuously by cephalin (PE) in liver and other fibr tissues, and this building-up process needs certain hour, therefore when meals choline is not enough, the endogenous resource remaining lecithin (PC) in body can supplement human body needs; 2, to the regulating action of serum lipids: regulate serum lipid level to mean and can reduce cholesterol levels, protection liver, also can Improving memory power, booster immunization power and lipotropic vigor; 3, healthy heart: in the sixties in 20th century, scientists just finds that lecithin may have the effect of cardioprotection, in further studying, finally confirm that lecithin has positive role to health of heart, this is because it can regulate the content of cholesterol in human body, effectively reduce the incidence of disease of cholesterol, high fat of blood and coronary heart disease; 4, useful brain: in cranial nerve cell, the content of lecithin accounts for 17% ~ 20% of its quality, " choline " is the basis of lecithin, the ample supply of lecithin ensures that " choline " synthesizes " acetylcholine " with " acetyl " in human body fully, " acetylcholine " is IC a kind of Information Conduction material, thus improve the activate degree of brain cell, improve memory and intellectual level; 5, prevention and therapy arteriosclerosis: the effect that lecithin has emulsification, cuts grease, blood circulation can be promoted, improve serum lipids, remove peroxide, Blood Cholesterol and neutral fat content are reduced, reduce fat in the holdup time of blood vessel, promote the dissipation of atherosis spot, prevent the blood vessel internal membrane damage caused by cholesterol.Take lecithin, to high fat of blood and high cholesterol, there is significant effect, thus can prevention and therapy arteriosclerosis (hypertension, miocardial infarction, cerebral hemorrhage); 6, Palmitoleic Acid: lecithin is the indispensable material of each cell of human body, if lacked, the power of regeneration of Skin Cell will be reduced, cause pachylosis, have wrinkle, if suitably absorb lecithin, skin regeneration vigor just can ensure, adds the good hydrophily of lecithin and lipophile, and skin is certainly just glossy.In addition, the inositol contained by lecithin or the main nutrient of hair, can suppress alopecia, makes white hair slowly blackening, 7, delay senility: people with age, memory can go down, its reason and acetyl choline content deficiency have certain relation, it is the main cause causing senile dementia that the neurotransmitter (acetylcholine) of brain reduces, compound required when acetylcholine is the transmission of nervous system information, and " choline " is the basis of lecithin, the ample supply of lecithin has the acetyl in enough choline and human body to be combined into " acetylcholine " by guarantee body, thus become brain sufficient Information Conduction material is provided, large brain-capacity directly absorbs lecithin and choline from blood, and be converted into acetylcholine very soon, the long-term lecithin that supplements can slow down the process be losing one's memory, the generation of prevention or postponement senile dementia, 8, adjustment psychology: social competition is growing more intense, under people are in nervous environment and all pressure for a long time, often suffer from the diseases such as anxiety, irritability, irritability, insomnia, tinnitus, i.e. vegetative nervous disorder, is commonly called neurasthenia, often supplement lecithin, cerebral nerve can be made to obtain nutritional supplementation in time, and the duty of keeping fit, is beneficial to dispelling fatigue, intensify brain cell, improve the disease such as irritability, irritability, insomnia caused because of nervous, 9, PFT is activated: alveolar is the cell of picked-up oxygen in body, alveolar is moistening, the oxygen sucked easily dissolves, otherwise then causes body anoxic, and lecithin has good hydrophily, alveolar can be made to keep moistening, thus improve the intake of body oxygen, more weak or smoker's alveolar dry, take the photograph hypoxgia for PFT, and motion, easier to be tired because of anoxic after work, should lecithin be supplemented more.
Lecithin has been processed to various health food, as soft capsule, tablet etc., does not also find the emulsification preparation containing lecithin.
Adverse influence is, lecithin and have the composition of collaborative pharmacological action with lecithin, and its existence largely affects composition digesting and assimilating in human body, is all absorbed in the mode of Passive diffusion in vivo; In addition, different formula combination, formulation, preparation method or existing way, its bioavilability is also significantly different.
Summary of the invention
Inventor surprisingly finds, other liposoluble substance of collaborative pharmacological action is had to make emulsification preparation by lecithin with lecithin, be conducive to fully absorbing of lecithin and other liposoluble substance, can their producing level of large increase, and better pharmacology synergy.
The invention provides a kind of emulsion compositions containing lecithin, other liposoluble substance and water, in described composition, the content of water is greater than 70% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm; Other liposoluble substance described comprises one or more compositions following: arachidonic acid, leukotrienes (comprising alpha-linolenic acid or gamma-Linolenic acid), linoleic acid, CLA, conjugated linoleic acid glyceride, phosphatidylserine, Polyene Phosphatidylcholine, phosphatidyl-ethanolamine, phosphatidylinositols, phosphatidyl glycerol, phytosterol, phytosterin ester, plant stanol ester, middle LCFA;
Preferably, above-mentioned emulsion composition provided by the invention, in described composition, the content of water is greater than 75% with mass ratio range, and the fat globule particle diameter in emulsion is less than 3 μm, such as, make the fat globule particle diameter in liquid be 2 μm, 1 μm etc.;
Preferably, above-mentioned emulsion composition provided by the invention, in described composition, the content of water is greater than 80% with mass ratio range, and the fat globule particle diameter in emulsion is less than 2 μm, such as, make the fat globule particle diameter in liquid be 1 μm, 0.5 μm, 0.3 μm etc.
Should illustrate and it will be understood by those skilled in the art that, lecithin of the present invention, arachidonic acid, leukotrienes (comprising alpha-linolenic acid or gamma-Linolenic acid), linoleic acid, CLA, conjugated linoleic acid glyceride, phosphatidylserine, Polyene Phosphatidylcholine, phosphatidyl-ethanolamine, phosphatidylinositols, phosphatidyl glycerol, phytosterol, phytosterin ester, plant stanol ester, middle LCFAs etc. are all fats or liposoluble substance, normally extract from vegetable oil or yolk, or synthesize compound more further after extracting from vegetable oil, such as, lecithin extracts from soybean oil or yolk, phosphatidylserine is for raw material with lecithin and Serine, after adopting phosphatidase conversion reaction, obtained after purifying, again such as, phytosterol comprises the cupreol, campesterol, stigmasterol etc. that extract from soybean oil, rapeseed oil, corn oil, sunflower oil, Tall oil,
On the other hand, lecithin of the present invention, arachidonic acid, alpha-linolenic acid, gamma-Linolenic acid, linoleic acid, CLA, conjugated linoleic acid glyceride, phosphatidylserine, Polyene Phosphatidylcholine, phosphatidyl-ethanolamine, phosphatidylinositols, phosphatidyl glycerol, phytosterol, phytosterin ester, plant stanol ester, these fats such as middle LCFA or liposoluble substance, usual meeting is present in vegetable fat with the ratio of certain content, special, above-mentioned liposoluble substance of the present invention also comprises the vegetable oil containing these liposoluble substances, such as, lecithin is present in soybean oil extract or oleic acid with the content of 40 ~ 60%, lecithin, phosphatidyl-ethanolamine, the ratio that phosphatidylinositols and phosphatidyl glycerol are greater than 35% with total phospholipids content is present in krill oil, and leukotrienes exists in peony seed oil or eucommia ulmoides seed oil with the content being greater than 40%, and linoleic acid exists silybum marianum seed oil with the content of 20% ~ 40%, safflower seed oil, Suaeda salsa seed oil or tea seed oil in, etc.,
Should illustrate and understand, lecithin of the present invention, arachidonic acid, leukotrienes, alpha-linolenic acid, gamma-Linolenic acid, linoleic acid, CLA, conjugated linoleic acid glyceride, phosphatidylserine, Polyene Phosphatidylcholine, phosphatidyl-ethanolamine, phosphatidylinositols, phosphatidyl glycerol, phytosterol, phytosterin ester, plant stanol ester or middle LCFA etc. both can be that sterling is applied to the present invention, also can be containing lecithin, arachidonic acid, alpha-linolenic acid, gamma-Linolenic acid, linoleic acid, CLA, conjugated linoleic acid glyceride, phosphatidylserine, Polyene Phosphatidylcholine, phosphatidyl-ethanolamine, phosphatidylinositols, phosphatidyl glycerol, phytosterol, phytosterin ester, the non-sterling of plant stanol ester or middle LCFA is applied to the present invention, such as be applied to the present invention with Vegetable oil or plant extracts oil, such as, linolenic acid content be greater than 40% in peony seed oil or eucommia ulmoides seed oil as linolenic donor, directly apply to the present invention, linoleic acid content 20% ~ 55% silybum marianum seed oil, safflower seed oil, Suaeda salsa seed oil or tea seed oil, as linoleic donor, directly apply to the present invention.
Concrete, the invention provides a kind of emulsion compositions containing lecithin, arachidonic acid and water, in described composition, the content of water is greater than 75% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm, such as, the fat globule particle diameter in liquid is made to be 3 μm, 1 μm, 0.5 μm, 0.3 μm etc.;
Concrete, the invention provides a kind of emulsion compositions containing lecithin, alpha-linolenic acid and water, in described composition, the content of water is greater than 75% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm, such as, the fat globule particle diameter in liquid is made to be 3 μm, 1 μm, 0.5 μm, 0.3 μm etc.;
Concrete, the invention provides a kind of emulsion compositions containing lecithin, gamma-Linolenic acid and water, in described composition, the content of water is greater than 75% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm, such as, the fat globule particle diameter in liquid is made to be 3 μm, 1 μm, 0.5 μm, 0.3 μm etc.;
Concrete, the invention provides a kind of emulsion compositions containing lecithin, linoleic acid and water, in described composition, the content of water is greater than 75% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm, such as, the fat globule particle diameter in liquid is made to be 3 μm, 1 μm, 0.5 μm, 0.3 μm etc.;
Concrete, the invention provides a kind of emulsion compositions containing lecithin, CLA (or conjugated linoleic acid glyceride) and water, in described composition, the content of water is greater than 75% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm, such as, the fat globule particle diameter in liquid is made to be 3 μm, 1 μm, 0.5 μm, 0.3 μm etc.;
Concrete, the invention provides a kind of emulsion compositions containing lecithin, phosphatidylserine and water, in described composition, the content of water is greater than 75% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm, such as, the fat globule particle diameter in liquid is made to be 3 μm, 1 μm, 0.5 μm, 0.3 μm etc.;
Concrete, the invention provides a kind of emulsion compositions containing lecithin, Polyene Phosphatidylcholine and water, in described composition, the content of water is greater than 75% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm, such as, the fat globule particle diameter in liquid is made to be 3 μm, 1 μm, 0.5 μm, 0.3 μm etc.;
Concrete, the invention provides a kind of emulsion compositions containing lecithin, phosphatidyl-ethanolamine and water, in described composition, the content of water is greater than 75% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm, such as, the fat globule particle diameter in liquid is made to be 3 μm, 1 μm, 0.5 μm, 0.3 μm etc.;
Concrete, the invention provides a kind of emulsion compositions containing lecithin, phosphatidyl-4 alcohol and water, in described composition, the content of water is greater than 75% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm, such as, the fat globule particle diameter in liquid is made to be 3 μm, 1 μm, 0.5 μm, 0.3 μm etc.;
Concrete, the invention provides a kind of emulsion compositions containing lecithin, phosphatidyl glycerol and water, in described composition, the content of water is greater than 75% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm, such as, the fat globule particle diameter in liquid is made to be 3 μm, 1 μm, 0.5 μm, 0.3 μm etc.;
Concrete, the invention provides a kind of containing lecithin, phytosterol (or phytosterin ester, or plant stanol ester) and the emulsion compositions of water, in described composition, the content of water is greater than 75% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm, such as, the fat globule particle diameter in liquid is made to be 3 μm, 1 μm, 0.5 μm, 0.3 μm etc.;
Concrete, the invention provides a kind of emulsion compositions containing lecithin, middle LCFA and water, in described composition, the content of water is greater than 75% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm, such as, the fat globule particle diameter in liquid is made to be 3 μm, 1 μm, 0.5 μm, 0.3 μm etc.;
Concrete, the invention provides a kind of emulsion compositions containing lecithin, linoleic acid, leukotrienes and water, in described composition, the content of water is greater than 75% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm, such as, the fat globule particle diameter in liquid is made to be 3 μm, 1 μm, 0.5 μm, 0.3 μm etc.;
Concrete, the invention provides a kind of emulsion compositions containing lecithin, CLA, gamma-Linolenic acid and water, in described composition, the content of water is greater than 75% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm, such as, the fat globule particle diameter in liquid is made to be 3 μm, 1 μm, 0.5 μm, 0.3 μm etc.;
Concrete, the invention provides a kind of containing lecithin, arachidonic acid, CLA, alpha-linolenic acid, phytosterol (or phytosterin ester, or plant stanol ester) and the emulsion compositions of water, in described composition, the content of water is greater than 75% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm, such as, the fat globule particle diameter in liquid is made to be 3 μm, 1 μm, 0.5 μm, 0.3 μm etc.;
Concrete, the invention provides a kind of emulsion compositions containing lecithin, arachidonic acid, alpha-linolenic acid, middle LCFA and water, in described composition, the content of water is greater than 75% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm, such as, the fat globule particle diameter in liquid is made to be 3 μm, 1 μm, 0.5 μm, 0.3 μm etc.;
Concrete, the invention provides a kind of emulsion compositions containing lecithin, arachidonic acid, CLA, alpha-linolenic acid, middle LCFA and water, in described composition, the content of water is greater than 75% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm, such as, the fat globule particle diameter in liquid is made to be 3 μm, 1 μm, 0.5 μm, 0.3 μm etc.;
Concrete, the invention provides a kind of containing lecithin, arachidonic acid, linoleic acid, phosphatidylserine, phytosterol (or phytosterin ester, or plant stanol ester) and the emulsion compositions of water, in described composition, the content of water is greater than 75% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm, such as, the fat globule particle diameter in liquid is made to be 3 μm, 1 μm, 0.5 μm, 0.3 μm etc.;
Concrete, the invention provides a kind of emulsion compositions containing lecithin, arachidonic acid, CLA and water, in described composition, the content of water is greater than 75% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm, such as, the fat globule particle diameter in liquid is made to be 3 μm, 1 μm, 0.5 μm, 0.3 μm etc.;
Concrete, the invention provides a kind of emulsion compositions containing lecithin, arachidonic acid, linoleic acid, CLA and water, in described composition, the content of water is greater than 75% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm, such as, the fat globule particle diameter in liquid is made to be 3 μm, 1 μm, 0.5 μm, 0.3 μm etc.;
Concrete, the invention provides a kind of emulsion compositions containing lecithin, arachidonic acid, linoleic acid, CLA, phosphatidylserine and water, in described composition, the content of water is greater than 75% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm, such as, the fat globule particle diameter in liquid is made to be 3 μm, 1 μm, 0.5 μm, 0.3 μm etc.;
Concrete, the invention provides a kind of emulsion compositions containing lecithin, arachidonic acid, linoleic acid, CLA and water, in described composition, the content of water is greater than 75% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm, such as, the fat globule particle diameter in liquid is made to be 3 μm, 1 μm, 0.5 μm, 0.3 μm etc.;
Concrete, the invention provides a kind of emulsion compositions containing lecithin, arachidonic acid, phosphatidyl-ethanolamine, CLA and water, in described composition, the content of water is greater than 75% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm, such as, the fat globule particle diameter in liquid is made to be 3 μm, 1 μm, 0.5 μm, 0.3 μm etc.;
Concrete, the invention provides a kind of emulsion compositions containing lecithin, arachidonic acid, phosphatidylinositols, CLA and water, in described composition, the content of water is greater than 75% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm, such as, the fat globule particle diameter in liquid is made to be 3 μm, 1 μm, 0.5 μm, 0.3 μm etc.;
Concrete, the invention provides a kind of emulsion compositions containing lecithin, arachidonic acid, phosphatidyl glycerol, CLA and water, in described composition, the content of water is greater than 75% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm, such as, the fat globule particle diameter in liquid is made to be 3 μm, 1 μm, 0.5 μm, 0.3 μm etc.;
Concrete, the invention provides a kind of emulsion compositions containing lecithin, arachidonic acid, CLA, middle LCFA and water, in described composition, the content of water is greater than 75% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm, such as, the fat globule particle diameter in liquid is made to be 3 μm, 1 μm, 0.5 μm, 0.3 μm etc.;
Concrete, the invention provides a kind of emulsion compositions containing lecithin, leukotrienes, middle LCFA and water, in described composition, the content of water is greater than 75% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm, such as, the fat globule particle diameter in liquid is made to be 3 μm, 1 μm, 0.5 μm, 0.3 μm etc.;
Concrete, the invention provides a kind of containing lecithin, arachidonic acid, CLA, phytosterol (or phytosterin ester, or plant stanol ester), the emulsion compositions of middle LCFA and water, in described composition, the content of water is greater than 75% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm, such as, the fat globule particle diameter in liquid is made to be 3 μm, 1 μm, 0.5 μm, 0.3 μm etc.;
Concrete, the invention provides a kind of emulsion compositions containing lecithin, arachidonic acid, CLA, alpha-linolenic acid, middle LCFA and water, in described composition, the content of water is greater than 75% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm, such as, the fat globule particle diameter in liquid is made to be 3 μm, 1 μm, 0.5 μm, 0.3 μm etc.;
Concrete, the invention provides a kind of containing lecithin, arachidonic acid, gamma-Linolenic acid, CLA, phosphatidylserine, phytosterol (or phytosterin ester, or plant stanol ester) and the emulsion compositions of water, in described composition, the content of water is greater than 75% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm, such as, the fat globule particle diameter in liquid is made to be 3 μm, 1 μm, 0.5 μm, 0.3 μm etc.
Further, the emulsion compositions containing lecithin water that the present invention is above-mentioned, optionally can also contain sweetener, described sweetener is selected from that stevioside, fructose, xylitol, sucrose, Sucralose, D-sorbite, HFCS, protein sugar, Aspartame, acesulfame potassium, stachyose, knob are sweet, at least one in glucose, honey, polyglucose.
Further; in the present composition; can also other one or more functional components be contained, nutrition or other compositions wholesome etc. such as such as inositol, l-cn, vitamin B2, vitamin B12, vitamin C, vitamin E, vitamin D, taurine, oligoisomaltose, probio, Bifidobacterium, ginseng, Antrodia camphorata, barrenwort, Cordyceps militaris, agate coffee, eucommia Bark male flower.
Emulsion compositions of the present invention, the emulsion that a kind of chyle fat is formed, be one complicated, thermodynamic stable system, especially different grease classes or fat-soluble ingredient, because the fat-water distribution of each component is with different in conjunction with energy state, stability for whole system is vital, multi-component fat breast system, be easy to occur fat floating, the wild effects such as flocculation or layering, production method and technique, decide form and the size of fat globule in emulsion, and whether can there is the microphenomenons such as gathering, thus affect the fat floating of emulsion in macroscopic aspect, the instability such as flocculation or layering, certainly, also emulsion digesting and assimilating and utilizing in human body is affected.
Further, the invention provides a kind of preparation method of the emulsion compositions containing lecithin, other liposoluble substance and purified water, it comprises: lecithin, other liposoluble substance mixed with water, emulsification and make uniform liquid, wherein the content of water is greater than 70% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm;
Especially, the invention provides a kind of preparation method of the emulsion compositions containing lecithin, other liposoluble substance and purified water, it comprises:
(1) prepare burden: take lecithin, other liposoluble substance by formula, add in purified water, be settled to required output, be uniformly mixed and be uniformly dispersed;
(2) emulsification: the liquid prepared in (1) is placed in emulsion tank, nitrogen or carbon dioxide is passed into continuously bottom emulsion tank, fluid temperature be 45 ~ 65 DEG C, under speed of agitator is greater than the condition of 2000r/min, carry out emulsification procedure 5 ~ 35min, then after emulsion being cooled to 25 DEG C in 5min, stop stirring and stopping passing into nitrogen or carbon dioxide, leave standstill;
Preferably, nitrogen or carbon dioxide intake are 10 ~ 80L/min, and emulsification speed of agitator is not less than 2800r/min;
(3) homogeneous: the emulsion that step (2) is obtained is filtered through 100 ~ 500 orders, filtrate is in temperature 50 ~ 98 DEG C, pressure is that 15 ~ 58MPa carries out homogeneous, optionally repeatedly homogeneous can be carried out, and make the fat globule particle diameter in emulsion be less than 5 μm, the fat globule particle diameter in liquid is preferably made to be less than 3 μm, the fat globule particle diameter in liquid is such as made to be 2 μm, 1 μm, 0.5 μm, 0.3 μm etc., homogeneous, refer to that the feed liquid of material is in extruding, material refinement is made under the triple role that thump and decompression expand, broken is more tiny, thus make material energy evenly mutual mixing, whole product system is more stable, preferably, the present invention proposes homogeneous treatment technology, through repeatedly homogeneous process, make lecithin, other liposoluble substance, the Homogeneous phase mixing such as purified water also keep stable homogeneous,
(4) filling, sterilizing: the emulsion after homogeneous is carried out vacuum outgas, canned, sealing, and sterilizing 4 seconds ~ 35 minutes under 85 ~ 135 DEG C of conditions;
(5) pack, check, obtain product of the present invention;
In described emulsion compositions, the content of purified water is greater than 70% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm, and in preferred described emulsion compositions, the content of purified water is greater than 75% with mass ratio range, and the fat globule particle diameter in emulsion is less than 3 μm;
Other liposoluble substance described comprises one or more compositions following: arachidonic acid, leukotrienes, alpha-linolenic acid, gamma-Linolenic acid, linoleic acid, CLA, conjugated linoleic acid glyceride, phosphatidylserine, Polyene Phosphatidylcholine, phosphatidyl-ethanolamine, phosphatidylinositols, phosphatidyl glycerol, phytosterol, phytosterin ester, plant stanol ester, middle LCFA.
The present invention surprisingly finds, the obtained emulsion containing lecithin, other liposoluble substance and water, fat globule particle diameter distributed effect is good, so-called domain size distribution effect, refer to particle size homogeneity, difference in size rate, form regularity etc., it is the most critical factor of reflection fat globule particle diameter and stability of emulsion.Especially in emulsification procedure, pass into gas (nitrogen or carbon dioxide), the blending and stirring and the cavitation that form gas and liquid when high-speed stirred is sheared are sheared, various fat-soluble ingredient energy rapid dispersion is made to be emulsified into the fat globule of uniform particle diameter, little and the narrow diameter distribution of fat globule particle diameter, and, adopt, in 5min, emulsion is quickly cooled to 25 DEG C, the form of fat globule is made to present homogeneous, regular spherical shape, fat globule drop is stoped to regroup, emulsion intercalation method tool is increased significantly, and significantly improves its bioavilability.
Further, the invention provides a kind of emulsion compositions containing lecithin, other liposoluble substance and purified water, in described emulsion compositions, the content of purified water is greater than 70% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm, in preferred described emulsion compositions, the content of purified water is greater than 75% with mass ratio range, and the fat globule particle diameter in emulsion is less than 3 μm; Other liposoluble substance described comprises one or more compositions following: arachidonic acid, alpha-linolenic acid, gamma-Linolenic acid, linoleic acid, CLA, conjugated linoleic acid glyceride, phosphatidylserine, Polyene Phosphatidylcholine, phosphatidyl-ethanolamine, phosphatidylinositols, phosphatidyl glycerol, phytosterol, phytosterin ester, plant stanol ester, middle LCFA;
Wherein, the preparation method of described emulsion compositions comprises:
(1) prepare burden: take lecithin, other liposoluble substance by formula, add in purified water, be settled to required output, be uniformly mixed and be uniformly dispersed;
(2) emulsification: the liquid prepared in (1) is placed in emulsion tank, nitrogen or carbon dioxide is passed into continuously bottom emulsion tank, fluid temperature be 45 ~ 65 DEG C, under speed of agitator is greater than the condition of 2000r/min, carry out emulsification procedure 5 ~ 35min, then after emulsion being cooled to 25 DEG C in 5min, stop stirring and stopping passing into nitrogen or carbon dioxide, leave standstill;
Preferably, nitrogen or carbon dioxide intake are 10 ~ 80L/min, and emulsification speed of agitator is not less than 2800r/min;
(3) homogeneous: the emulsion that step (2) is obtained is filtered through 100 ~ 500 orders, filtrate in temperature 50 ~ 98 DEG C, pressure be that 15 ~ 58MPa carries out homogeneous, optionally repeatedly homogeneous can be carried out, and make the fat globule particle diameter in emulsion be less than 5 μm, preferably make the fat globule particle diameter in liquid be less than 3 μm, such as, make the fat globule particle diameter in liquid be 2 μm, 1 μm, 0.5 μm, 0.3 μm etc.;
(4) filling, sterilizing: the emulsion after homogeneous is carried out vacuum outgas, canned, sealing, and sterilizing 4 seconds ~ 35 minutes under 85 ~ 135 DEG C of conditions;
(5) pack, check, to obtain final product;
Concrete, described emulsion compositions contains lecithin, arachidonic acid and purified water;
Concrete, described emulsion compositions contains lecithin, alpha-linolenic acid and purified water;
Concrete, described emulsion compositions contains lecithin, gamma-Linolenic acid and purified water;
Concrete, described emulsion compositions contains lecithin, linoleic acid and purified water;
Concrete, described emulsion compositions contains lecithin, CLA and purified water;
Concrete, described emulsion compositions contains lecithin, conjugated linoleic acid glyceride and purified water;
Concrete, described emulsion compositions contains lecithin, phosphatidylserine and purified water;
Concrete, described emulsion compositions contains lecithin, Polyene Phosphatidylcholine and purified water;
Concrete, described emulsion compositions contains lecithin, phosphatidyl-ethanolamine and purified water;
Concrete, described emulsion compositions contains lecithin, phosphatidylinositols and purified water;
Concrete, described emulsion compositions contains lecithin, phosphatidyl glycerol and purified water;
Concrete, described emulsion compositions contains lecithin, phytosterol (or phytosterin ester, or plant stanol ester) and purified water;
Concrete, described emulsion compositions contains lecithin, middle LCFA and purified water;
Concrete, described emulsion compositions contains lecithin, CLA, gamma-Linolenic acid and purified water;
Concrete, described emulsion compositions contains lecithin, arachidonic acid, CLA, alpha-linolenic acid, phytosterol (or phytosterin ester, or plant stanol ester) and purified water;
Concrete, described emulsion compositions contains lecithin, arachidonic acid, alpha-linolenic acid, middle LCFA and purified water;
Concrete, described emulsion compositions contains lecithin, arachidonic acid, linoleic acid, middle LCFA and purified water;
Concrete, described emulsion compositions contains lecithin, arachidonic acid, linoleic acid, alpha-linolenic acid, middle LCFA and purified water;
Concrete, described emulsion compositions contains lecithin, arachidonic acid, linoleic acid, leukotrienes, middle LCFA and purified water;
Concrete, described emulsion compositions contains lecithin, arachidonic acid, linoleic acid, CLA, alpha-linolenic acid, middle LCFA and purified water;
Concrete, described emulsion compositions contains lecithin, arachidonic acid, CLA, alpha-linolenic acid and purified water;
Concrete, described emulsion compositions contains lecithin, arachidonic acid, CLA, alpha-linolenic acid, middle LCFA and purified water;
Concrete, described emulsion compositions contains lecithin, arachidonic acid, CLA, phosphatidylserine, phytosterol (or phytosterin ester, or plant stanol ester) and purified water;
Concrete, described emulsion compositions contains lecithin, arachidonic acid, CLA and purified water;
Concrete, described emulsion compositions contains lecithin, Polyene Phosphatidylcholine, CLA and purified water;
Concrete, described emulsion compositions contains lecithin, arachidonic acid, Polyene Phosphatidylcholine, CLA and purified water;
Concrete, described emulsion compositions contains lecithin, arachidonic acid, phosphatidyl-ethanolamine, CLA and purified water;
Concrete, described emulsion compositions contains lecithin, arachidonic acid, phosphatidylinositols, CLA and purified water;
Concrete, described emulsion compositions contains lecithin, arachidonic acid, phosphatidyl glycerol, CLA and purified water;
Concrete, described emulsion compositions contains lecithin, arachidonic acid, CLA, middle LCFA and purified water;
Concrete, described emulsion compositions contains lecithin, gamma-Linolenic acid, middle LCFA and purified water;
Concrete, described emulsion compositions contains lecithin, arachidonic acid, CLA, phytosterol (or phytosterin ester, or plant stanol ester), middle LCFA and purified water;
Concrete, described emulsion compositions contains lecithin, arachidonic acid, CLA, alpha-linolenic acid, middle LCFA and purified water;
Concrete, described emulsion compositions contains lecithin, arachidonic acid, gamma-Linolenic acid, CLA, phosphatidylserine, phytosterol (or phytosterin ester, or plant stanol ester) and purified water;
Further, the emulsion compositions that the present invention is above-mentioned, optionally can also contain sweetener, described sweetener is selected from that stevioside, fructose, xylitol, sucrose, Sucralose, D-sorbite, HFCS, protein sugar, Aspartame, acesulfame potassium, stachyose, knob are sweet, at least one in glucose, honey, polyglucose.
Further; in the emulsion compositions that the present invention is above-mentioned; can also other one or more functional components be contained, nutrition or other compositions wholesome etc. such as such as inositol, l-cn, vitamin B2, vitamin B12, vitamin C, vitamin E, vitamin D, taurine, oligoisomaltose, probio, Bifidobacterium, ginseng, Antrodia camphorata, barrenwort, Cordyceps militaris, agate coffee, eucommia Bark male flower.
Should illustrate, the present invention contains the emulsion compositions of lecithin, other liposoluble substance and purified water, special, the filtration order number that it adopts is 100 ~ 500 orders, most preferably filtering order number is 250 ~ 500 orders, the heating temperature of preferred feed 35 ~ 80 DEG C, and preferred homogenization pressure is 25-58Mpa, the vacuum of preferred vacuum outgas is 0.04 ~ 0.09Mpa, preferred sterilising conditions be 115 ~ 121 DEG C 20 minutes.
Further, lecithin of the present invention and other liposoluble substance have good pharmacology synergy, for health, especially at oral supplementation phosphatide and unrighted acid, protection cardiovascular and cerebrovascular, reducing blood lipid, hypotensive, the effect aspects such as treatment fatty liver, there is good synergy, present invention also offers above-mentioned containing containing lecithin, the emulsion compositions of other liposoluble substance and purified water is for the preparation of oral supplementation phosphatide and unrighted acid, protection cardiovascular and cerebrovascular, reducing blood lipid, hypotensive, application in the healthy product for the treatment of fatty liver, described healthy product comprise medicine, medical food, health food or nutraceutical, in addition, the emulsion compositions that the present invention contains lecithin, other liposoluble substance and purified water can also be applied to cosmetics, for the nursing of skin and beauty treatment, etc.
The present invention surprisingly finds, obtained by the present invention containing lecithin, the emulsion of other liposoluble substance and water, fat globule particle diameter distributed effect is good, especially in emulsification procedure, pass into gas (nitrogen or carbon dioxide), the blending and stirring and the cavitation that form gas and liquid when high-speed stirred is sheared are sheared, various fat-soluble ingredient energy rapid dispersion is made to be emulsified into the fat globule of uniform particle diameter, little and the narrow diameter distribution of particle diameter, and, adopt, in 5min, emulsion is quickly cooled to 25 DEG C, the form of fat globule is presented homogeneous, regular spherical shape, fat globule drop can be well stoped to regroup, significantly improve emulsion intercalation method,
In addition, the present invention contains the emulsion of lecithin, other liposoluble substance and water, the little and narrow diameter distribution of fat globule particle diameter, and close to nano-scale, the oral absorption for it utilizes, significant, significantly improves its bioavilability.
Such as, be to be understood that, oral preparation needs just can enter blood of human body to reach physiological action through GI absorption, and the quality of oral absorption, directly affects the result for the treatment of of medicine.According to the concept of pharmacy, bioavilability (Bioavailability) refers to that preparation is rapidly absorbed into sanguimotor producing level and utilizes speed.Compare the preparation of other non-emulsified liquid type, the emulsion that the present invention contains lecithin, other liposoluble substance and water has excellent water-oiliness dissolubility, the oral drug preparation taking liposoluble substance as active ingredient is entered in sanguimotor degree and speed in absorption, there is significant facilitation and meaning.Preparation enters the absorption process after stomach and intestine, divide two stages, namely disintegration or dispersion and two stages of Gastrointestinal Wall Absorption, first need to scatter in gastric juice or intestinal juice, and then contact and be attached to gastrointestinal wall and carry out absorbing and entering blood, this two stages all can affect the performance with drug effect that absorbs of medicine, liposoluble substance is prepared as water dispersible good, extra small and the emulsion of narrow diameter distribution of fat globule particle diameter, stripping and the rate of dispersion of liposoluble substance are significantly accelerated, substantially increase degree and the rate of dispersion of its disintegration dispersion in gastric juice or intestinal juice, then the contact of liposoluble substance and gastrointestinal wall is more abundant, be attached to Gastrointestinal Wall Absorption and to enter the active ingredient of blood also more abundant, this raising for the bioavilability of liposoluble substance is significant.
detailed description of the inventionin implementation process of the present invention, those of ordinary skill in the art are not departing from the scope of the present invention various embodiment that the basis with Spirit Essence produces and are modifying apparent and be easily carry out.By the following examples application of the present invention etc. done and illustrate further, but do not represent embodiment limitation of the present invention.
Embodiment 1, compound lecithin emulsions and preparation method thereof
Recipe quantity by weight percentage, contains:
Lecithin 0.5% ~ 5.5%, is preferably 2.5%,
Arachidonic acid 0.03% ~ 3%, is preferably 1.5%,
Sucralose 0 ~ 0.05%, is preferably 0.01%,
Purified water adds to 100%;
Preparation: (1) prepares burden: take Sucralose by formula and add in purified water, make to dissolve completely, separately take lecithin, arachidonic acid, add in purified water successively, be settled to required output, be uniformly mixed and be uniformly dispersed;
(2) emulsification: the liquid prepared in (1) is placed in emulsion tank, nitrogen or the carbon dioxide of 20 ~ 30L/min is passed into continuously bottom emulsion tank, fluid temperature be 45 ~ 65 DEG C, under speed of agitator is greater than the condition of 2500r/min, carry out emulsification procedure 10 ~ 20min, then interlayer cooling water is passed into, after making emulsion be cooled to 25 DEG C in 5min, stop stirring and stopping passing into nitrogen or carbon dioxide, leave standstill;
(3) homogeneous: emulsion obtained for step (2) is filtered through 200 ~ 500 orders, filtrate in temperature 50 ~ 98 DEG C, pressure be that 25 ~ 35MPa carries out homogeneous;
(4) filling, sterilizing: the emulsion after homogeneous is carried out vacuum outgas, canned, sealing, and 115 ~ 121 DEG C of sterilizings 20 minutes;
(5) pack, check, obtain compound lecithin emulsions preparation;
Through laser diffraction analyzer, the fat globule particle size distribution of this emulsion formulations is at 2 ~ 3 μm, and taste has the fragrance of grease, slightly sweet taste.
Embodiment 2, composite phospholipid emulsion formulations and preparation method thereof
Recipe quantity by weight percentage, contains:
Lecithin 0.5% ~ 5%, is preferably 4.0%,
Phosphatidylserine 0.05% ~ 3%, is preferably 0.3%,
Purified water adds to 100%;
Preparation: (1) prepares burden: take lecithin, phosphatidylserine by formula, add in purified water successively, be settled to required output, be uniformly mixed and be uniformly dispersed;
(2) emulsification: the liquid prepared in (1) is placed in emulsion tank, nitrogen or the carbon dioxide of 20 ~ 30L/min is passed into continuously bottom emulsion tank, fluid temperature be 45 ~ 65 DEG C, under speed of agitator is greater than the condition of 2800r/min, carry out emulsification procedure 15 ~ 30min, then interlayer cooling water is passed into, after making emulsion be cooled to 25 DEG C in 5min, stop stirring and stopping passing into nitrogen or carbon dioxide, leave standstill;
(3) homogeneous: emulsion obtained for step (2) is filtered through 200 ~ 500 orders, filtrate in temperature 50 ~ 98 DEG C, pressure be that 45 ~ 55MPa carries out homogeneous;
(4) filling, sterilizing: the emulsion after homogeneous is carried out vacuum outgas, canned, sealing, and 115 ~ 121 DEG C of sterilizings 20 minutes;
(5) pack, check, obtain composite phospholipid emulsion;
Through laser diffraction analyzer, the fat globule particle size distribution of this emulsion formulations is at 0.5 ~ 1 μm, and taste has the fragrance of grease, optionally can add appropriate sweetener or taste modifying agent.
Embodiment 3, composite phospholipid emulsion and preparation method thereof
Recipe quantity by weight percentage, contains:
Lecithin 0.5% ~ 8%, is preferably 5.5%,
Peony seed oil leukotrienes (linolenic acid content >=38%) 0.5% ~ 10%, is preferably 1.5%(in linolenic acid content),
Purified water adds to 100%;
Preparation: (1) prepares burden: take lecithin, peony seed oil leukotrienes by formula, add successively in purified water, be settled to required output, be uniformly mixed and be uniformly dispersed;
(2) emulsification: the liquid prepared in (1) is placed in emulsion tank, nitrogen or the carbon dioxide of 20 ~ 30L/min is passed into continuously bottom emulsion tank, fluid temperature be 45 ~ 65 DEG C, under speed of agitator is greater than the condition of 2800r/min, carry out emulsification procedure 15 ~ 30min, then interlayer cooling water is passed into, after making emulsion be cooled to 25 DEG C in 5min, stop stirring and stopping passing into nitrogen or carbon dioxide, leave standstill;
(3) homogeneous: emulsion obtained for step (2) is filtered through 200 ~ 500 orders, filtrate in temperature 50 ~ 98 DEG C, pressure be that 45 ~ 55MPa carries out homogeneous;
(4) filling, sterilizing: the emulsion after homogeneous is carried out vacuum outgas, canned, sealing, and 115 ~ 121 DEG C of sterilizings 20 minutes;
(5) pack, check, obtain composite phospholipid emulsion formulations;
Through laser diffraction analyzer, the fat globule particle size distribution of this emulsion formulations is at 0.5 ~ 1 μm, and taste has the fragrance of grease, optionally can add appropriate sweetener or taste modifying agent.
Embodiment 4, composite phospholipid emulsion formulations and preparation method thereof
Recipe quantity by weight percentage, contains:
Lecithin 0.5% ~ 5%, is preferably 3.5%,
CLA 0.5% ~ 5%, is preferably 1.5%,
Phosphatidylserine 0.1% ~ 5%, is preferably 0.2%,
Purified water adds to 100%;
Preparation: (1) prepares burden: take lecithin, CLA, phosphatidylserine by formula, add in purified water successively, be settled to required output, be uniformly mixed and be uniformly dispersed;
(2) emulsification: the liquid prepared in (1) is placed in emulsion tank, nitrogen or the carbon dioxide of 20 ~ 30L/min is passed into continuously bottom emulsion tank, fluid temperature be 45 ~ 65 DEG C, under speed of agitator is greater than the condition of 2800r/min, carry out emulsification procedure 15 ~ 30min, then interlayer cooling water is passed into, after making emulsion be cooled to 25 DEG C in 5min, stop stirring and stopping passing into nitrogen or carbon dioxide, leave standstill;
(3) homogeneous: emulsion obtained for step (2) is filtered through 200 ~ 500 orders, filtrate in temperature 50 ~ 98 DEG C, pressure be that 45 ~ 55MPa carries out homogeneous;
(4) filling, sterilizing: the emulsion after homogeneous is carried out vacuum outgas, canned, sealing, and 115 ~ 121 DEG C of sterilizings 20 minutes;
(5) pack, check, obtain composite phospholipid emulsion formulations;
Through laser diffraction analyzer, the fat globule particle size distribution of this emulsion formulations is at 0.5 ~ 1 μm, and taste has the fragrance of grease, optionally can add appropriate sweetener or taste modifying agent.
Embodiment 5, composite phospholipid emulsion formulations and preparation method thereof
Recipe quantity by weight percentage, contains:
Lecithin 0.5% ~ 5%, is preferably 3.5%,
CLA 0.5% ~ 5%, is preferably 1.5%,
Phytosterol 0.2% ~ 1%, is preferably 0.5%,
Purified water adds to 100%;
Preparation: (1) prepares burden: take lecithin, CLA, phytosterol by formula, add in purified water successively, be settled to required output, be uniformly mixed and be uniformly dispersed;
(2) emulsification: the liquid prepared in (1) is placed in emulsion tank, nitrogen or the carbon dioxide of 20 ~ 30L/min is passed into continuously bottom emulsion tank, fluid temperature be 45 ~ 65 DEG C, under speed of agitator is greater than the condition of 2800r/min, carry out emulsification procedure 15 ~ 30min, then interlayer cooling water is passed into, after making emulsion be cooled to 25 DEG C in 5min, stop stirring and stopping passing into nitrogen or carbon dioxide, leave standstill;
(3) homogeneous: emulsion obtained for step (2) is filtered through 200 ~ 500 orders, filtrate in temperature 50 ~ 98 DEG C, pressure be that 45 ~ 55MPa carries out homogeneous;
(4) filling, sterilizing: the emulsion after homogeneous is carried out vacuum outgas, canned, sealing, and 115 ~ 121 DEG C of sterilizings 20 minutes;
(5) pack, check, obtain composite phospholipid emulsion formulations;
Through laser diffraction analyzer, the fat globule particle size distribution of this emulsion formulations is at 0.5 ~ 1 μm, and taste has the fragrance of grease, optionally can add appropriate sweetener or taste modifying agent.
Embodiment 6, composite phospholipid emulsion formulations and preparation method thereof
Recipe quantity by weight percentage, contains:
Lecithin 0.5% ~ 5%, is preferably 3.5%,
Alpha-linolenic acid eucommia ulmoides seed oil (alpha-linolenic acid >=45%) 0.03% ~ 2%, is preferably 1.5%,
CLA 0.5% ~ 5%, is preferably 1.5%,
Purified water adds to 100%;
Preparation: (1) prepares burden: take lecithin, alpha-linolenic acid eucommia ulmoides seed oil, CLA by formula, add successively in purified water, be settled to required output, be uniformly mixed and be uniformly dispersed;
(2) emulsification: the liquid prepared in (1) is placed in emulsion tank, nitrogen or the carbon dioxide of 20 ~ 30L/min is passed into continuously bottom emulsion tank, fluid temperature be 45 ~ 65 DEG C, under speed of agitator is greater than the condition of 2800r/min, carry out emulsification procedure 15 ~ 30min, then interlayer cooling water is passed into, after making emulsion be cooled to 25 DEG C in 5min, stop stirring and stopping passing into nitrogen or carbon dioxide, leave standstill;
(3) homogeneous: emulsion obtained for step (2) is filtered through 200 ~ 500 orders, filtrate in temperature 50 ~ 98 DEG C, pressure be that 45 ~ 55MPa carries out homogeneous;
(4) filling, sterilizing: the emulsion after homogeneous is carried out vacuum outgas, canned, sealing, and 115 ~ 121 DEG C of sterilizings 20 minutes;
(5) pack, check, obtain composite phospholipid emulsion formulations;
Through laser diffraction analyzer, the fat globule particle size distribution of this emulsion formulations is at 0.5 ~ 1 μm, and taste has the fragrance of grease, optionally can add appropriate sweetener or taste modifying agent.
Embodiment 7, composite phospholipid olefin(e) acid emulsion formulations and preparation method thereof
Recipe quantity by weight percentage, contains:
Lecithin 0.5% ~ 5%, is preferably 3%,
CLA 0.02% ~ 1%, is preferably 0.5%,
Phosphatidyl-ethanolamine 0.02% ~ 1%, is preferably 0.5%,
Arachidonic acid 0.02% ~ 1%, is preferably 0.5%,
Purified water adds to 100%;
Preparation: (1) prepares burden: take lecithin, CLA, phosphatidyl-ethanolamine, arachidonic acid by formula, add in purified water successively, be settled to required output, be uniformly mixed and be uniformly dispersed;
(2) emulsification: the liquid prepared in (1) is placed in emulsion tank, nitrogen or the carbon dioxide of 20 ~ 30L/min is passed into continuously bottom emulsion tank, fluid temperature be 45 ~ 65 DEG C, under speed of agitator is greater than the condition of 2800r/min, carry out emulsification procedure 15 ~ 30min, then interlayer cooling water is passed into, after making emulsion be cooled to 25 DEG C in 5min, stop stirring and stopping passing into nitrogen or carbon dioxide, leave standstill;
(3) homogeneous: emulsion obtained for step (2) is filtered through 200 ~ 500 orders, filtrate in temperature 50 ~ 98 DEG C, pressure be that 45 ~ 55MPa carries out homogeneous;
(4) filling, sterilizing: the emulsion after homogeneous is carried out vacuum outgas, canned, sealing, and 115 ~ 121 DEG C of sterilizings 20 minutes;
(5) pack, check, obtain composite phospholipid olefin(e) acid emulsion formulations;
Through laser diffraction analyzer, the fat globule particle size distribution of this emulsion formulations is at 0.5 ~ 1 μm, and taste has the fragrance of grease, optionally can add appropriate sweetener or taste modifying agent.
Embodiment 8, composite phospholipid olefin(e) acid emulsion formulations and preparation method thereof
Recipe quantity by weight percentage, contains:
Lecithin 0.5% ~ 5%, is preferably 2.5%,
CLA 0.02% ~ 1%, is preferably 0.3%,
Arachidonic acid 0.02% ~ 1%, is preferably 0.2%,
Polyene Phosphatidylcholine 0.02% ~ 10%, is preferably 5%,
Purified water adds to 100%;
Preparation: (1) prepares burden: take lecithin, CLA, arachidonic acid, Polyene Phosphatidylcholine by formula, add in purified water successively, be settled to required output, be uniformly mixed and be uniformly dispersed;
(2) emulsification: the liquid prepared in (1) is placed in emulsion tank, nitrogen or the carbon dioxide of 20 ~ 30L/min is passed into continuously bottom emulsion tank, fluid temperature be 45 ~ 65 DEG C, under speed of agitator is greater than the condition of 2800r/min, carry out emulsification procedure 15 ~ 30min, then interlayer cooling water is passed into, after making emulsion be cooled to 25 DEG C in 5min, stop stirring and stopping passing into nitrogen or carbon dioxide, leave standstill;
(3) homogeneous: emulsion obtained for step (2) is filtered through 200 ~ 500 orders, filtrate in temperature 50 ~ 98 DEG C, pressure be that 45 ~ 55MPa carries out homogeneous;
(4) filling, sterilizing: the emulsion after homogeneous is carried out vacuum outgas, canned, sealing, and 115 ~ 121 DEG C of sterilizings 20 minutes;
(5) pack, check, obtain composite phospholipid olefin(e) acid emulsion formulations;
Through laser diffraction analyzer, the fat globule particle size distribution of this emulsion formulations is at 0.3 ~ 0.7 μm, and taste has the fragrance of grease, optionally can add appropriate sweetener or taste modifying agent.
Embodiment 9, composite phospholipid olefin(e) acid sterol emulsion and preparation method thereof
Recipe quantity by weight percentage, contains:
Lecithin 0.5% ~ 5%, is preferably 3.5%,
Linoleic acid 0.5% ~ 5%, is preferably 1%,
CLA 0.02% ~ 1%, is preferably 0.5%,
Arachidonic acid 0.02% ~ 1%, is preferably 0.2%,
Leukotrienes 0.02% ~ 1%, is preferably 0.2%,
Phosphatidylserine 0.02% ~ 1%, is preferably 0.2%,
Phytosterol 0.02% ~ 1%, is preferably 0.5%,
Phosphatidyl-ethanolamine 0.02% ~ 1%, is preferably 0.2%,
Middle LCFA 0.5% ~ 5%, is preferably 1.5%,
Purified water adds to 100%;
Preparation: (1) prepares burden: take lecithin, linoleic acid, CLA, arachidonic acid, leukotrienes, phosphatidylserine, phytosterol, phosphatidyl-ethanolamine, middle LCFA by formula, add successively in purified water, be settled to required output, be uniformly mixed and be uniformly dispersed;
(2) emulsification: the liquid prepared in (1) is placed in emulsion tank, nitrogen or the carbon dioxide of 25L/min is passed into continuously bottom emulsion tank, fluid temperature be 45 ~ 55 DEG C, under the condition of speed of agitator 2800r/min, carry out emulsification procedure 20min, then interlayer cooling water is passed into, after making emulsion be cooled to 25 DEG C in 5min, stop stirring and stopping passing into nitrogen, leave standstill;
(3) homogeneous: emulsion obtained for step (2) is filtered through 500 orders, filtrate in temperature 80 ~ 90 DEG C, pressure be that 30MPa carries out homogeneous;
(4) filling, sterilizing: the emulsion after homogeneous is carried out vacuum outgas, canned, sealing, and 115 ~ 121 DEG C of sterilizings 20 minutes;
(5) pack, check, obtain composite phospholipid olefin(e) acid sterol emulsion formulations;
Through laser diffraction analyzer, the fat globule particle size distribution of this emulsion formulations is at 0.5 ~ 1 μm, and taste has the fragrance of grease, optionally can add appropriate sweetener or taste modifying agent.
The application in following of embodiment 10, composite phospholipid emulsion described in embodiment 1 to embodiment 9
Application in the healthy product preparing oral supplementation phosphatide or unrighted acid;
Application in the healthy product of preparation protection cardiovascular and cerebrovascular;
Application in the healthy product of preparation reducing blood lipid;
Application in the healthy product of preparation treatment fatty liver;
Application in the healthy product that preparation is hypotensive;
In preparation to the application in the cosmetics of skin nursing and beauty treatment.
Embodiment 11, composite phospholipid emulsion intercalation method of the present invention are studied
Completely according to the preferred amounts formula of embodiment 9, be prepared into emulsion according to a conventional method, the preferred amounts composite phospholipid olefin(e) acid sterol emulsion prepared with embodiment 9 carry out respectively centrifugal, heat and boil and thawing 5 times repeatedly, the states of matter change before and after contrast operation, its stability of analysis and comparison.Result is as following table 1.
Table 1
| Relatively content | Fat globule domain size distribution | 500r/min is centrifugal | 1000r/min is centrifugal | 2000r/min is centrifugal | 20min is boiled in heating | Thawing 5 times repeatedly |
| Embodiment 9 composite phospholipid olefin(e) acid sterol emulsion | 0.5 ~ 1 μm, narrow diameter distribution | Without significant change | Without significant change | Without significant change | Without significant change | Without significant change |
| The emulsion that conventional method is made | 8 ~ 22 μm, domain size distribution is wide | Without significant change | A small amount of oil droplet is separated out | More oil droplet is separated out, liquid layered, uneven color | A small amount of oil droplet is separated out | More oil droplet is separated out, liquid layered, uneven color |
As can be seen from Table 1, composite phospholipid emulsion intercalation method of the present invention is significantly higher than conventional fat type emulsion.
The bioavailability study of embodiment 12, composite phospholipid emulsion of the present invention
The present invention contains the emulsion of lecithin, other liposoluble substance and water, the little and narrow diameter distribution of fat globule particle diameter, and close to nano-scale, the oral absorption for it utilizes, significant; Such as, be to be understood that, oral preparation needs just can enter blood of human body to reach physiological action through GI absorption, and the quality of oral absorption, directly affects the result for the treatment of of medicine.According to the concept of pharmacy, bioavilability (Bioavailability) refers to that preparation is rapidly absorbed into sanguimotor producing level and utilizes speed.Compare the preparation of other non-emulsified liquid type, the present invention contain lecithin, the emulsion of other liposoluble substance and water has excellent water-oiliness dissolubility, the oral drug preparation taking liposoluble substance as active ingredient is entered in sanguimotor degree and speed in absorption, there is significant facilitation and meaning.Preparation enters the absorption process after stomach and intestine, divide two stages, namely disintegration or dispersion and two stages of Gastrointestinal Wall Absorption, first need to scatter in gastric juice or intestinal juice, and then contact and be attached to gastrointestinal wall and carry out absorbing and entering blood, this two stages all can affect the performance with drug effect that absorbs of medicine, liposoluble substance is prepared as water dispersible good, extra small and the emulsion of narrow diameter distribution of fat globule particle diameter, stripping and the rate of dispersion of liposoluble substance are significantly accelerated, substantially increase degree and the rate of dispersion of its disintegration dispersion in gastric juice or intestinal juice, then the contact of liposoluble substance and gastrointestinal wall is more abundant, be attached to Gastrointestinal Wall Absorption and to enter the active ingredient of blood also more abundant, this raising for the bioavilability of liposoluble substance is significant.
Take entirely according to the formula of embodiment 9, be prepared into according to a conventional method and emulsion, the composite phospholipid olefin(e) acid sterol emulsion prepared with the embodiment of the present invention 9, with under condition, gives rat oral gavage respectively, carries out studying the bioavilability of the total oleic acid comparing two kinds of emulsions; Result of study finds, compound lecithin emulsions of the present invention is compared with the made emulsion of conventional method, and the bioavilability of total oleic acid improves more than 39%, demonstrates the raising of the highly significant of composite phospholipid emulsion of the present invention in bioavilability.
Claims (10)
1. one kind contains lecithin, the emulsion compositions of other liposoluble substance and water, in composition, the content of water is greater than 70% with mass ratio range, other liposoluble substance described comprises one or more compositions following: arachidonic acid, leukotrienes (comprising alpha-linolenic acid or gamma-Linolenic acid), linoleic acid, CLA, conjugated linoleic acid glyceride, phosphatidylserine, Polyene Phosphatidylcholine, phosphatidyl-ethanolamine, phosphatidylinositols, phosphatidyl glycerol, phytosterol, phytosterin ester, plant stanol ester, middle LCFA, wherein, the preparation method of described emulsion compositions comprises: by lecithin, other liposoluble substance mixes with water, emulsification and make uniform liquid, wherein the content of water is greater than 70% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm.
2. the preparation method of emulsion compositions according to claim 1, it comprises:
(1) prepare burden: take lecithin, other liposoluble substance by formula, add in purified water, be settled to required output, be uniformly mixed and be uniformly dispersed;
(2) emulsification: the liquid prepared in (1) is placed in emulsion tank, nitrogen or carbon dioxide is passed into continuously bottom emulsion tank, fluid temperature be 45 ~ 65 DEG C, under speed of agitator is greater than the condition of 2000r/min, carry out emulsification procedure 5 ~ 35min, then after emulsion being cooled to 25 DEG C in 5min, stop stirring and stopping passing into nitrogen or carbon dioxide, leave standstill;
Preferably, nitrogen or carbon dioxide intake are 10 ~ 80L/min, and emulsification speed of agitator is not less than 2800r/min;
(3) homogeneous: emulsion obtained for step (2) is filtered through 100 ~ 500 orders, filtrate is that 15 ~ 58MPa carries out homogeneous in temperature 50 ~ 98 DEG C, pressure, and makes the fat globule particle diameter in emulsion be less than 5 μm;
(4) filling, sterilizing: the emulsion after homogeneous is carried out vacuum outgas, canned, sealing, and sterilizing 4 seconds ~ 35 minutes under 85 ~ 135 DEG C of conditions;
(5) pack, check, to obtain final product;
In described emulsion compositions, the content of purified water is greater than 70% with mass ratio range, and the fat globule particle diameter in emulsion is less than 5 μm; Other liposoluble substance described comprises one or more compositions following: arachidonic acid, leukotrienes, alpha-linolenic acid, gamma-Linolenic acid, linoleic acid, CLA, conjugated linoleic acid glyceride, phosphatidylserine, Polyene Phosphatidylcholine, phosphatidyl-ethanolamine, phosphatidylinositols, phosphatidyl glycerol, phytosterol, phytosterin ester, plant stanol ester, middle LCFA.
3. the emulsion compositions containing lecithin, other liposoluble substance and purified water, in described emulsion compositions, the content of purified water is greater than 70% with mass ratio range, and other liposoluble substance comprises one or more compositions following: arachidonic acid, alpha-linolenic acid, gamma-Linolenic acid, linoleic acid, CLA, conjugated linoleic acid glyceride, phosphatidylserine, Polyene Phosphatidylcholine, phosphatidyl-ethanolamine, phosphatidylinositols, phosphatidyl glycerol, phytosterol, phytosterin ester, plant stanol ester, middle LCFA;
Wherein, the preparation method of described emulsion compositions comprises:
(1) prepare burden: take lecithin, other liposoluble substance by formula, add in purified water, be settled to required output, be uniformly mixed and be uniformly dispersed;
(2) emulsification: the liquid prepared in (1) is placed in emulsion tank, nitrogen or carbon dioxide is passed into continuously bottom emulsion tank, fluid temperature be 45 ~ 65 DEG C, under speed of agitator is greater than the condition of 2000r/min, carry out emulsification procedure 5 ~ 35min, then after emulsion being cooled to 25 DEG C in 5min, stop stirring and stopping passing into nitrogen or carbon dioxide, leave standstill;
(3) homogeneous: the emulsion that step (2) is obtained is filtered through 100 ~ 500 orders, and filtrate is that 15 ~ 58MPa carries out homogeneous in temperature 50 ~ 98 DEG C, pressure, optionally can carry out repeatedly homogeneous, and make the fat globule particle diameter in emulsion be less than 5 μm;
(4) filling, sterilizing: the emulsion after homogeneous is carried out vacuum outgas, canned, sealing, and sterilizing 4 seconds ~ 35 minutes under 85 ~ 135 DEG C of conditions;
(5) pack, check, to obtain final product.
4. according to claim 1 or emulsion compositions according to claim 3, wherein:
Described emulsion compositions contains lecithin, arachidonic acid and purified water;
Described emulsion compositions contains lecithin, alpha-linolenic acid and purified water;
Described emulsion compositions contains lecithin, gamma-Linolenic acid and purified water;
Described emulsion compositions contains lecithin, linoleic acid and purified water;
Described emulsion compositions contains lecithin, CLA and purified water;
Described emulsion compositions contains lecithin, conjugated linoleic acid glyceride and purified water;
Described emulsion compositions contains lecithin, phosphatidylserine and purified water;
Described emulsion compositions contains lecithin, Polyene Phosphatidylcholine and purified water;
Described emulsion compositions contains lecithin, phosphatidyl-ethanolamine and purified water;
Described emulsion compositions contains lecithin, phosphatidylinositols and purified water;
Described emulsion compositions contains lecithin, phosphatidyl glycerol and purified water;
Described emulsion compositions contains lecithin, phytosterol (or phytosterin ester, or plant stanol ester) and purified water;
Described emulsion compositions contains lecithin, middle LCFA and purified water;
Described emulsion compositions contains lecithin, CLA, gamma-Linolenic acid and purified water;
Described emulsion compositions contains lecithin, arachidonic acid, CLA, alpha-linolenic acid, phytosterol (or phytosterin ester, or plant stanol ester) and purified water;
Described emulsion compositions contains lecithin, arachidonic acid, alpha-linolenic acid, middle LCFA and purified water;
Described emulsion compositions contains lecithin, arachidonic acid, linoleic acid, middle LCFA and purified water;
Described emulsion compositions contains lecithin, arachidonic acid, linoleic acid, alpha-linolenic acid, middle LCFA and purified water;
Described emulsion compositions contains lecithin, arachidonic acid, linoleic acid, leukotrienes, middle LCFA and purified water;
Described emulsion compositions contains lecithin, arachidonic acid, linoleic acid, CLA, alpha-linolenic acid, middle LCFA and purified water;
Described emulsion compositions contains lecithin, arachidonic acid, CLA, alpha-linolenic acid and purified water;
Described emulsion compositions contains lecithin, arachidonic acid, CLA, alpha-linolenic acid, middle LCFA and purified water;
Described emulsion compositions contains lecithin, arachidonic acid, CLA, phosphatidylserine, phytosterol (or phytosterin ester, or plant stanol ester) and purified water;
Described emulsion compositions contains lecithin, arachidonic acid, CLA and purified water;
Described emulsion compositions contains lecithin, Polyene Phosphatidylcholine, CLA and purified water;
Described emulsion compositions contains lecithin, arachidonic acid, Polyene Phosphatidylcholine, CLA and purified water;
Described emulsion compositions contains lecithin, arachidonic acid, phosphatidyl-ethanolamine, CLA and purified water;
Described emulsion compositions contains lecithin, arachidonic acid, phosphatidylinositols, CLA and purified water;
Described emulsion compositions contains lecithin, arachidonic acid, phosphatidyl glycerol, CLA and purified water;
Described emulsion compositions contains lecithin, arachidonic acid, CLA, middle LCFA and purified water;
Described emulsion compositions contains lecithin, gamma-Linolenic acid, middle LCFA and purified water;
Described emulsion compositions contains lecithin, arachidonic acid, CLA, phytosterol (or phytosterin ester, or plant stanol ester), middle LCFA and purified water;
Described emulsion compositions contains lecithin, arachidonic acid, CLA, alpha-linolenic acid, middle LCFA and purified water;
Or described emulsion compositions contains lecithin, arachidonic acid, gamma-Linolenic acid, CLA, phosphatidylserine, phytosterol (or phytosterin ester, or plant stanol ester) and purified water.
5. a composite phospholipid emulsion, its recipe quantity by weight percentage, contains:
Lecithin 0.5% ~ 5%,
Phosphatidylserine 0.05% ~ 3%,
Purified water adds to 100%;
Preparation: (1) prepares burden: take lecithin, phosphatidylserine by formula, add in purified water successively, be settled to required output, be uniformly mixed and be uniformly dispersed;
(2) emulsification: the liquid prepared in (1) is placed in emulsion tank, nitrogen or the carbon dioxide of 20 ~ 30L/min is passed into continuously bottom emulsion tank, fluid temperature be 45 ~ 65 DEG C, under speed of agitator is greater than the condition of 2800r/min, carry out emulsification procedure 15 ~ 30min, then interlayer cooling water is passed into, after making emulsion be cooled to 25 DEG C in 5min, stop stirring and stopping passing into nitrogen or carbon dioxide, leave standstill;
(3) homogeneous: emulsion obtained for step (2) is filtered through 200 ~ 500 orders, filtrate in temperature 50 ~ 98 DEG C, pressure be that 45 ~ 55MPa carries out homogeneous;
(4) filling, sterilizing: the emulsion after homogeneous is carried out vacuum outgas, canned, sealing, and 115 ~ 121 DEG C of sterilizings 20 minutes;
(5) pack, check, to obtain final product.
6. a composite phospholipid emulsion, its recipe quantity by weight percentage, contains:
Lecithin 0.5% ~ 8%,
Peony seed oil leukotrienes (linolenic acid content >=38%) 0.5% ~ 10%(is in linolenic acid content),
Purified water adds to 100%;
Preparation: (1) prepares burden: take lecithin, peony seed oil leukotrienes by formula, add successively in purified water, be settled to required output, be uniformly mixed and be uniformly dispersed;
(2) emulsification: the liquid prepared in (1) is placed in emulsion tank, nitrogen or the carbon dioxide of 20 ~ 30L/min is passed into continuously bottom emulsion tank, fluid temperature be 45 ~ 65 DEG C, under speed of agitator is greater than the condition of 2800r/min, carry out emulsification procedure 15 ~ 30min, then interlayer cooling water is passed into, after making emulsion be cooled to 25 DEG C in 5min, stop stirring and stopping passing into nitrogen or carbon dioxide, leave standstill;
(3) homogeneous: emulsion obtained for step (2) is filtered through 200 ~ 500 orders, filtrate in temperature 50 ~ 98 DEG C, pressure be that 45 ~ 55MPa carries out homogeneous;
(4) filling, sterilizing: the emulsion after homogeneous is carried out vacuum outgas, canned, sealing, and 115 ~ 121 DEG C of sterilizings 20 minutes;
(5) pack, check, to obtain final product.
7. a composite phospholipid emulsion, its recipe quantity by weight percentage, contains:
Lecithin 0.5% ~ 5%,
CLA 0.5% ~ 5%,
Phosphatidylserine 0.1% ~ 5%,
Purified water adds to 100%;
Preparation: (1) prepares burden: take lecithin, CLA, phosphatidylserine by formula, add in purified water successively, be settled to required output, be uniformly mixed and be uniformly dispersed;
(2) emulsification: the liquid prepared in (1) is placed in emulsion tank, nitrogen or the carbon dioxide of 20 ~ 30L/min is passed into continuously bottom emulsion tank, fluid temperature be 45 ~ 65 DEG C, under speed of agitator is greater than the condition of 2800r/min, carry out emulsification procedure 15 ~ 30min, then interlayer cooling water is passed into, after making emulsion be cooled to 25 DEG C in 5min, stop stirring and stopping passing into nitrogen or carbon dioxide, leave standstill;
(3) homogeneous: emulsion obtained for step (2) is filtered through 200 ~ 500 orders, filtrate in temperature 50 ~ 98 DEG C, pressure be that 45 ~ 55MPa carries out homogeneous;
(4) filling, sterilizing: the emulsion after homogeneous is carried out vacuum outgas, canned, sealing, and 115 ~ 121 DEG C of sterilizings 20 minutes;
(5) pack, check, to obtain final product.
8. a composite phospholipid olefin(e) acid emulsion, its recipe quantity by weight percentage, contains:
Lecithin 0.5% ~ 5%,
CLA 0.02% ~ 1%,
Phosphatidyl-ethanolamine 0.02% ~ 1%,
Arachidonic acid 0.02% ~ 1%,
Purified water adds to 100%;
Preparation: (1) prepares burden: take lecithin, CLA, phosphatidyl-ethanolamine, arachidonic acid by formula, add in purified water successively, be settled to required output, be uniformly mixed and be uniformly dispersed;
(2) emulsification: the liquid prepared in (1) is placed in emulsion tank, nitrogen or the carbon dioxide of 20 ~ 30L/min is passed into continuously bottom emulsion tank, fluid temperature be 45 ~ 65 DEG C, under speed of agitator is greater than the condition of 2800r/min, carry out emulsification procedure 15 ~ 30min, then interlayer cooling water is passed into, after making emulsion be cooled to 25 DEG C in 5min, stop stirring and stopping passing into nitrogen or carbon dioxide, leave standstill;
(3) homogeneous: emulsion obtained for step (2) is filtered through 200 ~ 500 orders, filtrate in temperature 50 ~ 98 DEG C, pressure be that 45 ~ 55MPa carries out homogeneous;
(4) filling, sterilizing: the emulsion after homogeneous is carried out vacuum outgas, canned, sealing, and 115 ~ 121 DEG C of sterilizings 20 minutes;
(5) pack, check, to obtain final product.
9. a composite phospholipid olefin(e) acid sterol emulsion, its recipe quantity by weight percentage, contains:
Lecithin 0.5% ~ 5%,
Linoleic acid 0.5% ~ 5%,
CLA 0.02% ~ 1%,
Arachidonic acid 0.02% ~ 1%,
Leukotrienes 0.02% ~ 1%,
Phosphatidylserine 0.02% ~ 1%,
Phytosterol 0.02% ~ 1%,
Phosphatidyl-ethanolamine 0.02% ~ 1%,
Middle LCFA 0.5% ~ 5%,
Purified water adds to 100%;
Preparation: (1) prepares burden: take lecithin, linoleic acid, CLA, arachidonic acid, leukotrienes, phosphatidylserine, phytosterol, phosphatidyl-ethanolamine, middle LCFA by formula, add successively in purified water, be settled to required output, be uniformly mixed and be uniformly dispersed;
(2) emulsification: the liquid prepared in (1) is placed in emulsion tank, nitrogen or the carbon dioxide of 25L/min is passed into continuously bottom emulsion tank, fluid temperature be 45 ~ 55 DEG C, under the condition of speed of agitator 2800r/min, carry out emulsification procedure 20min, then interlayer cooling water is passed into, after making emulsion be cooled to 25 DEG C in 5min, stop stirring and stopping passing into nitrogen, leave standstill;
(3) homogeneous: emulsion obtained for step (2) is filtered through 500 orders, filtrate in temperature 80 ~ 90 DEG C, pressure be that 30MPa carries out homogeneous;
(4) filling, sterilizing: the emulsion after homogeneous is carried out vacuum outgas, canned, sealing, and 115 ~ 121 DEG C of sterilizings 20 minutes; (5) pack, check, to obtain final product.
10. the application of any one emulsion compositions described in claim 1 to claim 9 in following:
Application in the healthy product preparing oral supplementation phosphatide or unrighted acid;
Application in the healthy product of preparation protection cardiovascular and cerebrovascular;
Application in the healthy product of preparation reducing blood lipid;
Application in the healthy product of preparation treatment fatty liver;
Application in the healthy product that preparation is hypotensive;
In preparation to the application in the cosmetics of skin nursing and beauty treatment.
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| CN106720463A (en) * | 2016-11-21 | 2017-05-31 | 菏泽尧舜牡丹生物科技有限公司 | A kind of peony seed oil containing phosphatidylserine and preparation method thereof |
| CN107744024A (en) * | 2016-09-20 | 2018-03-02 | 福建奥正投资发展有限公司 | Hydrophilic lipid composite, it is prepared and concocting method and application |
| CN107912765A (en) * | 2016-10-07 | 2018-04-17 | 福建奥正投资发展有限公司 | The composition of lipid component and high viscosity food containing water, its preparation method, be applied in combination and apply |
| CN109430659A (en) * | 2018-12-25 | 2019-03-08 | 哈尔滨氧态健康科技股份有限公司 | A kind of peony seed oil cream and preparation method thereof |
| CN109964954A (en) * | 2019-04-03 | 2019-07-05 | 宜兴兴农化工制品有限公司 | A kind of environmentally protective High-efficient Water fundamental mode Pesticidal combination containing Diacloden and gamma cyhalothrin |
| CN114680190A (en) * | 2020-12-29 | 2022-07-01 | 丰益(上海)生物技术研发中心有限公司 | Oil composition for formula milk and preparation method thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107744024A (en) * | 2016-09-20 | 2018-03-02 | 福建奥正投资发展有限公司 | Hydrophilic lipid composite, it is prepared and concocting method and application |
| CN107912765A (en) * | 2016-10-07 | 2018-04-17 | 福建奥正投资发展有限公司 | The composition of lipid component and high viscosity food containing water, its preparation method, be applied in combination and apply |
| CN106720463A (en) * | 2016-11-21 | 2017-05-31 | 菏泽尧舜牡丹生物科技有限公司 | A kind of peony seed oil containing phosphatidylserine and preparation method thereof |
| CN106617078A (en) * | 2017-01-22 | 2017-05-10 | 四川创生生物科技有限公司 | Composition capable of lowering hyperglycemia, hyperlipemia and hypertension and compounded soft capsules prepared from composition |
| CN109430659A (en) * | 2018-12-25 | 2019-03-08 | 哈尔滨氧态健康科技股份有限公司 | A kind of peony seed oil cream and preparation method thereof |
| CN109964954A (en) * | 2019-04-03 | 2019-07-05 | 宜兴兴农化工制品有限公司 | A kind of environmentally protective High-efficient Water fundamental mode Pesticidal combination containing Diacloden and gamma cyhalothrin |
| CN114680190A (en) * | 2020-12-29 | 2022-07-01 | 丰益(上海)生物技术研发中心有限公司 | Oil composition for formula milk and preparation method thereof |
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