CN107812194A - Hydrophilic lipid composite, it prepares and concocting method and is applied in combination - Google Patents
Hydrophilic lipid composite, it prepares and concocting method and is applied in combination Download PDFInfo
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- CN107812194A CN107812194A CN201710896585.3A CN201710896585A CN107812194A CN 107812194 A CN107812194 A CN 107812194A CN 201710896585 A CN201710896585 A CN 201710896585A CN 107812194 A CN107812194 A CN 107812194A
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- oil
- lipid composite
- acid
- emulsifying agent
- hydrophily
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Abstract
The present invention, which provides, contains liquid aliphatic, liposoluble substance B and emulsifying agent hydrophily lipid composite, the liquid aliphatic is selected from leukotrienes, medium chain triglyceride etc., the emulsifying agent is selected from phosphatide, sucrose fatty ester etc., the liposoluble substance B is selected from lutein ester, lutein, Co-Q10, carrotene, astaxanthin, lycopene, isoflavones, the hydrophily lipid composite passes through mixing in water fluid, shake rolling, it can be formed in 1~5 second homogeneous, stable emulsion, be advantageous to the quick of lipid composite and water fluid, convenient allotment, with instant allotment, immediately the advantages of using, it is also beneficial to oral absorption and the utilization of liquid aliphatic and liposoluble substance B, greatly facilitate the instant allotment of user, immediately use;Present invention also offers its composition and its packaging compositions, allotment application method, and its application in terms of medicine, special medicine purposes formula food, health food or nutraceutical is prepared.
Description
Technical field
It is specifically hydrophilic containing health-nutrition effect or pharmacological action material the present invention relates to a kind of healthy product composition
Property lipid composite, and preparation method thereof, its allotment uses and applies.
Healthy product composition of the present invention, including medicine, special medicine purposes formula food, health food, nutrition
Food, cosmetics etc., the composition specifically containing emulsifying agent, water-free liquid aliphatic class.
Background technology
On the one hand, it is well known that lipid material and water are completely incompatible, but in healthy product in use, past
Toward needing the lipid material with health-nutrition effect or pharmacological action to be used with fat-soluble health-nutrition material simultaneously, especially
Its for being used for fatty acid nutritive and other liposoluble substances in special medicine purposes formula food or medicine simultaneously and
Need by oral administration or during intestinal absorption, generally require it is previously prepared into emulsion with water fluid, it is but this previously prepared
Emulsion, in order to keep the stability of emulsion, extend commercially available storage life, the emulsifying agent added with a large amount of even excess, simultaneously
In order to keep the stability of unrighted acid, also added with substantial amounts of antioxidant, preservative, and alkali compounds is used, such as
Sodium hydroxide adjusts the pH value of emulsion, and these are unfavorable for the oral absorption of aliphatic acid, or even can bring health risk;Again
Person, liquid aliphatic, especially unrighted acid and ester, such as leukotrienes, linoleic acid, oleic acid hold very much in aqueous mixed liquor
Oxidizable, degraded, the especially temperature more than 40 DEG C, meeting accelerated degradation, cause a large amount of losses of unrighted acid, and seriously
Influence the quality safety of composition.
On the other hand, liquid aliphatic is very greasy when directly drinking and is difficult to receive;Therefore prior art is led to
Cross and soft capsule is made in liquid aliphatic and other liposoluble substances is orally ingested, it is convenient that this is unfavorable for being orally ingested very much
Property, also it is unfavorable for being orally ingested for larger dose, nor be beneficial to oral absorption.
Generally, the composition of water-free liquid aliphatic and liposoluble substance, it has good stability, but water-free fat
Based composition, its oiliness is strong, and completely immiscible and swim on the water surface with water, lipid composite and water can not be made by stirring or rocking
Well mixed, this allotment for lipid composite is using totally unfavorable, in medical product or healthy food etc. in use, it makes
With scope critical constraints, particularly with needing lipid composite being well mixed with aqua, or need to adjust lipid composite
Homogenate diet that can be oral in nutraceutical/special medicine purposes formula food is made into, is very difficult;Also, also to expire
Sufficient user quickly and easily carries out the allotment with water fluid, and deployed mixed liquor is in emulsion, and is not susceptible to meat
The visible layering of eye, be advantageous to edible and use.
In actual applications, the composition of water-free liquid aliphatic and liposoluble substance, is configured to water fluid
, especially should in reality such as preparation nutraceutical, special medicine purposes formula food, medicines when being easy to the Product Status being orally ingested
With or Clinical practice in, following four condition should be met:
1st, there is hydrophily, can be mixed with water fluid and disperse to form emulsion, to improve the greasy mouth that it is difficult to receive
Sense;
2nd, stir or rock in a reservoir with water fluid, homogeneous emulsion can be formed in a short period of time, such as 10
Homogeneous emulsion is formed in second, to ensure quick and convenience when preparing;
3rd, the emulsion formed with water fluid has preferable stability, is susceptible to significantly be layered, such as at least
Visible layering did not occurred in 1 minute, so that user has the longer time drunk or be orally ingested;
4th, the emulsion formed through slight wobble, can still form homogeneous emulsion, in favor of making after standing is layered
User drinks or is orally ingested by phased manner.
Clearly for water-free lipid composite, prior art can not meet this above-mentioned four conditions, typically will not
Aqueous lipid composite makes the preparation of soft capsule to use, and this strongly limits the intake demand of consumer or patient, example
Such as, the patient of EN support is needed for that can not be swallowed, this soft capsule preparation is that its tube feed can not be taken in
, it also limit oral absorption and the utilization of liquid aliphatic and other liposoluble substances.
The content of the invention
It is an object of the invention to provide a kind of liquid aliphatic and the composition of liposoluble substance, this lipid composite has
Excellent hydrophily, both ensure that lipid composite production, storage transport, shelf life product quality, again be beneficial to using
When allocated, dissolved with water fluid, can quickly and easily use.
The invention provides the hydrophily lipid composite containing liquid aliphatic, liposoluble substance B and emulsifying agent, the fat
After based composition mixes with water fluid, shaken by shaking, emulsion can be formed.Further, present invention also offers its packages groups
Compound, preparation method, and it quickly leached in water fluid and formed emulsion lipid composite and its concocting method,
Using
Liquid aliphatic of the present invention, is defined as presenting the aliphatic acid or grease of liquid at normal temperatures and pressures, including saturation or
Undersaturated aliphatic acid, saturation or undersaturated grease, the triglycerides of saturated or undersaturated aliphatic acid, saturation or unsaturation
Aliphatic acid diglyceride, such as including but not limited to oleic acid, linoleic acid, leukotrienes, medium chain triglyceride, diglyceride,
Middle long chain fatty acids, etc..
The present invention provides the hydrophily lipid composite containing liquid aliphatic, liposoluble substance B and emulsifying agent, the liquid
Fat is selected from following one or more materials:Oleic acid, linoleic acid, leukotrienes, medium chain triglyceride, diglyceride, middle long-chain fat
Fat acid, wherein content of the liquid aliphatic in hydrophily lipid composite are more than 45% with weight ratio meter;
The emulsifying agent is selected from following one or more materials:Phosphatide, sucrose fatty ester, list, it is diglycerine fatty acid ester, poly- sweet
Oil and fat acid esters, methyl glycol fatty acid ester, lactic acid fatty glyceride, polysorbas20, polysorbate40, polysorbate60, Tween 80, sapn
20th, the content of span 40, sorbester p18, sorbester p38, sorbester p17, wherein emulsifying agent in hydrophily lipid composite is with weight ratio meter
For 0.05%~8%, content of the preferred emulsifier in hydrophily lipid composite is using weight ratio meter as 0.1%~6%;
The liposoluble substance B is selected from following one or more materials:Lutein ester, lutein, Co-Q10, carrotene, shrimp
Blue or green element, lycopene, isoflavones, wherein contents of the liposoluble substance B in hydrophily lipid composite is with weight ratio meter
For 0.01%~30%;
The leukotrienes includes alpha-linolenic acid or gamma-Linolenic acid, and the carrotene includes beta carotene or alpha-carotene, institute
Stating middle long chain fatty acids includes medium chain fatty acid or long chain fatty acids.
On the other hand, liquid aliphatic of the present invention would generally be present in grease with the ratio of certain content, the present invention
The liquid aliphatic can also be with containing the liquid aliphatic vegetable oil or animal oil, or from vegetable oil or animal oil
The compound or grease for further synthesizing or fermenting again after extraction are applied to the present invention.For example, alpha-linolenic acid content is more than 30%
Donor as alpha-linolenic acid of Purple Perilla Seed Oil, linseed oil, peony seed oil, oil and fat of sacha inchi or eucommia ulmoides seed oil, applied to this hair
It is bright;Gamma-linolenic acid oil donor as gamma-Linolenic acid of the gamma -linolenic acid content more than 8%, evening primrose oil, blackcurrant oil,
Borage oil also can be as the donor plant oil of gamma-Linolenic acid, applied to the present invention;
For example, the soybean oil of oleic acid or linoleic acid content more than 40%, corn oil, peanut oil, sunflower oil, olive oil, fine grinding
Ji seed oil, amygdalus pedunculata pall oil, palm oil, sesame oil, Semen Juglandis oil, rapeseed oil, safflower seed oil, grape-kernel oil, rice bran oil, capsicum
Seed oil, Fructus Zanthoxyli oil, canola, coconut oil, cottonseed oil, wheat-germ oil, eucommia ulmoides seed oil, tomato seed oil, silybum marianum seed oil,
Pumpkin seed oil, krill oil, Camellia oil, including tea seed oil, camellia seed oil or tea oil, amygdalus pedunculata pall oil, smooth bark Lai wood fruit oil,
Suaeda salsa seed oil, oil and fat of sacha inchi, rhus glabra oil, peony seed oil, samara oil, imperial rice bran oil, granada seed oil, brucea fruit oil, the moon
See careless oil, blackcurrant oil, shea butter, borage oil, Litsea cubeba oil, pine-seed oil, hemp-seed oil, nut oil, canola oil or life
Ginger oil is as oleic acid or linoleic donor, applied to the present invention;
For example, contain the medium chain fatty acid more than 11%, the long chain fatty acids more than 10% in middle long chain fatty acids edible oil, in
The donor of long chain fatty acids, medium chain fatty acid or long chain fatty acids during long chain fatty acids edible oil can be used as, applied to the present invention;
For example, soybean lecithin of the total phospholipids content more than 35%, krill oil, soybean lecithin, yolk phospholipid, egg yolk lecithin are made
For the donor of phosphatide, applied to the present invention.
Further, the present invention provides the hydrophily lipid combination containing liquid aliphatic, liposoluble substance B and emulsifying agent
Thing, the emulsifying agent are selected from following one or more materials:Phosphatide, sucrose fatty ester, list, it is diglycerine fatty acid ester, poly- sweet
Oil and fat acid esters, methyl glycol fatty acid ester, lactic acid fatty glyceride, polysorbas20, polysorbate40, polysorbate60, Tween 80, sapn
20th, span 40, sorbester p18, sorbester p38, sorbester p17;Wherein content of the emulsifying agent in hydrophily lipid composite is with weight ratio meter
For 0.05%~8%, content of the preferred emulsifier in hydrophily lipid composite is using weight ratio meter as 0.1%~6%;It is described
Liquid aliphatic is selected from medium chain triglyceride and following one or more materials:Oleic acid, linoleic acid, alpha-linolenic acid, gamma-Linolenic acid,
Diglyceride, middle long chain fatty acids, wherein content of the medium chain triglyceride in hydrophily lipid composite using weight ratio meter as
10%~99%, using weight ratio meter as 20%~99%, preferably medium chain triglyceride contains for the preferred content of medium chain triglyceride
Amount is using weight ratio meter as 45%~98%;The liposoluble substance B is selected from following one or more materials:Lutein ester, leaf are yellow
Element, Co-Q10, carrotene, astaxanthin, lycopene, isoflavones, wherein liposoluble substance B combine in hydrophily lipid
Content in thing is using weight ratio meter as 0.01%~30%, preferred contents of the liposoluble substance B in hydrophily lipid composite
Using weight ratio meter as 0.03%~20%;The middle long chain fatty acids include medium chain fatty acid or long chain fatty acids, the emulsification
Agent also includes its various model, specification, the degree of polymerization, esterification degree, mono-/bis-ester, or its monomer component for including, the phosphatide include
Lecithin, phosphatidyl-ethanolamine, phosphatidylinositols or phosphatidyl glycerol;
Contents of the liposoluble substance B in hydrophily lipid composite is using weight ratio meter as 0.01%~30%, preferred fat
Using weight ratio meter as 0.03%~20%, preferably liposoluble substance B's contents of the soluble substance B in hydrophily lipid composite exists
Content in hydrophily lipid composite is using weight ratio meter as 0.05%~15%, and preferably liposoluble substance B is in hydrophily lipid
Content in composition is using weight ratio meter as 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%,
0.08%th, 0.09%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%,
1.1%th, 1.2%, 1.3%, 1.4%, 1.5%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%,
2.3%th, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%,
3.6%th, 3.7%, 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%,
4.9%th, 5%, 5.1%, 5.2%, 5.3%, 5.4%, 5.5%, 5.6%, 5.7%, 5.8%, 5.9%, 6%, 6.1%,
6.2%th, 6.3%, 6.4%, 6.5%, 6.6%, 6.7%, 6.8%, 6.9%, 7%, 7.1%, 7.2%, 7.3%, 7.4%,
7.5%th, 7.6%, 7.7%, 7.8%, 7.9%, 8%, 8.1%, 8.2%, 8.3%, 8.4%, 8.5%, 8.6%, 8.7%,
8.8%th, 8.9%, 9%, 9.1%, 9.2%, 9.3%, 9.4%, 9.5%, 9.6%, 9.7%, 9.8%, 9.9%, 10%,
11%th, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%,
26%th, 27%, 28%, 29%, 30%.
Further, the present invention provides the hydrophily lipid combination containing liquid aliphatic, liposoluble substance B and emulsifying agent
Thing, the emulsifying agent are selected from following one or more materials:Phosphatide, sucrose fatty ester, list, it is diglycerine fatty acid ester, poly- sweet
Oil and fat acid esters, methyl glycol fatty acid ester, lactic acid fatty glyceride, polysorbas20, polysorbate40, polysorbate60, Tween 80, sapn
20th, the content of span 40, sorbester p18, sorbester p38, sorbester p17, wherein emulsifying agent in hydrophily lipid composite is with weight ratio meter
For 0.05%~8%;The liquid aliphatic is selected from leukotrienes and following one or more materials:Oleic acid, linoleic acid, medium chain triglyceride
Three esters, diglyceride, middle long chain fatty acids, wherein content of the leukotrienes in hydrophily lipid composite using weight ratio meter as
1%~99%;The liposoluble substance B is selected from following one or more materials:Lutein ester, lutein, Co-Q10, carrot
Element, astaxanthin, lycopene, isoflavones, wherein contents of the liposoluble substance B in hydrophily lipid composite is with weight
Than being calculated as 0.01%~30%, the leukotrienes includes alpha-linolenic acid or gamma-Linolenic acid.
Further, the present invention provides the hydrophily lipid combination containing liquid aliphatic, liposoluble substance B and emulsifying agent
Thing, the emulsifying agent are selected from following one or more materials:Phosphatide, sucrose fatty ester, list, it is diglycerine fatty acid ester, poly- sweet
Oil and fat acid esters, methyl glycol fatty acid ester, lactic acid fatty glyceride, polysorbas20, polysorbate40, polysorbate60, Tween 80, sapn
20th, the content of span 40, sorbester p18, sorbester p38, sorbester p17, wherein emulsifying agent in hydrophily lipid composite is with weight ratio meter
For 0.05%~8%;The liquid aliphatic is selected from linoleic acid and following one or more materials:Oleic acid, alpha-linolenic acid, γ-Asia
Numb acid, medium chain triglyceride, diglyceride, middle long chain fatty acids, content of its Linoleic acid in hydrophily lipid composite
Using weight ratio meter as 1%~99%;The liposoluble substance B is selected from following one or more materials:Lutein ester, lutein,
Co-Q10, carrotene, astaxanthin, lycopene, isoflavones, wherein liposoluble substance B is in hydrophily lipid composite
In content using weight ratio meter as 0.01%~30%.
Further, the present invention provides the hydrophily lipid combination containing liquid aliphatic, liposoluble substance B and emulsifying agent
Thing, the emulsifying agent are selected from following one or more materials:Phosphatide, sucrose fatty ester, list, it is diglycerine fatty acid ester, poly- sweet
Oil and fat acid esters, methyl glycol fatty acid ester, lactic acid fatty glyceride, polysorbas20, polysorbate40, polysorbate60, Tween 80, sapn
20th, the content of span 40, sorbester p18, sorbester p38, sorbester p17, wherein emulsifying agent in hydrophily lipid composite is with weight ratio meter
For 0.05%~8%;The liquid aliphatic is selected from oleic acid and following one or more materials:Linoleic acid, alpha-linolenic acid, γ-Asia
Numb acid, medium chain triglyceride, diglyceride, middle long chain fatty acids, wherein content of the oleic acid in hydrophily lipid composite with
Weight ratio meter is 1%~99%;The liposoluble substance B is selected from following one or more materials:It is lutein ester, lutein, auxiliary
Enzyme Q10, carrotene, astaxanthin, lycopene, isoflavones, wherein liposoluble substance B is in hydrophily lipid composite
Content using weight ratio meter as 0.01%~30%.
Further specifically, present invention offer is a kind of to contain the hydrophilic of emulsifying agent, medium chain triglyceride and liposoluble substance B
Property lipid composite, the liposoluble substance B are selected from following one or more materials:Lutein ester, lutein, Co-Q10, Hu
Radish element, astaxanthin, lycopene, isoflavones, wherein content of the medium chain triglyceride in hydrophily lipid composite with
Weight ratio meter is 1%~99.5%, content of the emulsifying agent in hydrophily lipid composite using weight ratio meter as 0.05%~
8%, using weight ratio meter as 0.2%~4%, liposoluble substance B's content of the preferred emulsifier in hydrophily lipid composite exists
Content in hydrophily lipid composite is using weight ratio meter as 0.01%~30%, and preferably liposoluble substance B is in hydrophily lipid
Content in composition is using weight ratio meter as 0.03%~20%, and preferably liposoluble substance B is in hydrophily lipid composite
Content is using weight ratio meter as 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%,
0.09%th, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%,
1.3%th, 1.4%, 1.5%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%,
2.5%th, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%,
3.8%th, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5%,
5.1%th, 5.2%, 5.3%, 5.4%, 5.5%, 5.6%, 5.7%, 5.8%, 5.9%, 6%, 6.1%, 6.2%, 6.3%,
6.4%th, 6.5%, 6.6%, 6.7%, 6.8%, 6.9%, 7%, 7.1%, 7.2%, 7.3%, 7.4%, 7.5%, 7.6%,
7.7%th, 7.8%, 7.9%, 8%, 8.1%, 8.2%, 8.3%, 8.4%, 8.5%, 8.6%, 8.7%, 8.8%, 8.9%,
9%th, 9.1%, 9.2%, 9.3%, 9.4%, 9.5%, 9.6%, 9.7%, 9.8%, 9.9%, 10%, 11%, 12%,
13%th, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%,
28%th, 29%, 30%.
Further specifically, the present invention provides a kind of hydrophily lipid containing emulsifying agent, leukotrienes and liposoluble substance B
Composition, the liposoluble substance B are selected from following one or more materials:Lutein ester, lutein, Co-Q10, carrotene,
The content of astaxanthin, lycopene, isoflavones, wherein leukotrienes in hydrophily lipid composite using weight ratio meter as
1%~99.5%, the leukotrienes includes alpha-linolenic acid or gamma-Linolenic acid, emulsifying agent containing in hydrophily lipid composite
Amount using weight ratio meter as 0.05%~8%, content of the preferred emulsifier in hydrophily lipid composite using weight ratio meter as
The content of 0.3%~2.5%, liposoluble substance B in hydrophily lipid composite is excellent using weight ratio meter as 0.01%~30%
Contents of the liposoluble substance B in hydrophily lipid composite is selected using weight ratio meter as 0.03%~20%, preferably fat-soluble thing
Contents of the matter B in hydrophily lipid composite is using weight ratio meter as 0.01%, 0.02%, 0.03%, 0.04%, 0.05%,
0.06%th, 0.07%, 0.08%, 0.09%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%,
0.9%th, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%,
2.1%th, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%, 3.3%,
3.4%th, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%,
4.7%th, 4.8%, 4.9%, 5%, 5.1%, 5.2%, 5.3%, 5.4%, 5.5%, 5.6%, 5.7%, 5.8%, 5.9%,
6%th, 6.1%, 6.2%, 6.3%, 6.4%, 6.5%, 6.6%, 6.7%, 6.8%, 6.9%, 7%, 7.1%, 7.2%,
7.3%th, 7.4%, 7.5%, 7.6%, 7.7%, 7.8%, 7.9%, 8%, 8.1%, 8.2%, 8.3%, 8.4%, 8.5%,
8.6%th, 8.7%, 8.8%, 8.9%, 9%, 9.1%, 9.2%, 9.3%, 9.4%, 9.5%, 9.6%, 9.7%, 9.8%,
9.9%th, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%,
24%th, 25%, 26%, 27%, 28%, 29%, 30%.
The present invention provides a kind of hydrophily lipid composite, contains liquid aliphatic, emulsifying agent, liposoluble substance B, the fat
Soluble substance B in lutein ester, lutein, Co-Q10, carrotene, astaxanthin, lycopene, isoflavones one
Kind is a variety of, and wherein content of the liquid aliphatic in hydrophily lipid composite is using weight ratio meter as 45%~99%, emulsifying agent
Using weight ratio meter as 0.05%~8%, preferred emulsifier combines content in hydrophily lipid composite in hydrophily lipid
Content in thing is using weight ratio meter as 0.1%~6%, and content of the preferred emulsifier in hydrophily lipid composite is with weight ratio
Be calculated as 0.3%~2.5%, contents of the liposoluble substance B in hydrophily lipid composite using weight ratio meter as 0.01%~
30%, preferably contents of the liposoluble substance B in hydrophily lipid composite is using weight ratio meter as 0.04%~20%, preferred fat
Contents of the soluble substance B in hydrophily lipid composite is using weight ratio meter as 0.06%~15%;
Wherein, the liquid aliphatic is linoleic acid;
The liquid aliphatic is oleic acid;
The liquid aliphatic is diglyceride;
The liquid aliphatic is middle long chain fatty acids;
The liquid aliphatic is oleic acid and linoleic acid;
The liquid aliphatic is linolenic and linoleic, and leukotrienes includes alpha-linolenic acid or gamma-Linolenic acid;
The liquid aliphatic is leukotrienes and medium chain triglyceride, and leukotrienes includes alpha-linolenic acid or gamma-Linolenic acid;
The liquid aliphatic is linoleic acid and medium chain triglyceride;
The liquid aliphatic is medium chain triglyceride, linoleic acid plus linolenic acid, and leukotrienes includes alpha-linolenic acid or gamma-Linolenic acid;
The liquid aliphatic is medium chain triglyceride, leukotrienes, linoleic plus oleic acid, and leukotrienes includes alpha-linolenic acid or γ-Asia
Numb acid;
The liquid aliphatic is medium chain triglyceride and middle long chain fatty acids;
The liquid aliphatic is medium chain triglyceride and diglyceride;
The liquid aliphatic is leukotrienes and diglyceride, and leukotrienes includes alpha-linolenic acid or gamma-Linolenic acid;
The liquid aliphatic is diglyceride and linoleic acid;
The liquid aliphatic is diglyceride, linoleic acid plus linolenic acid, and leukotrienes includes alpha-linolenic acid or gamma-Linolenic acid;
The liquid aliphatic is middle long chain fatty acids and diglyceride;
The liquid aliphatic is leukotrienes and middle long chain fatty acids, and leukotrienes includes alpha-linolenic acid or gamma-Linolenic acid;
Or the liquid aliphatic is linoleic acid and middle long chain fatty acids.
Combined specifically, the present invention provides a kind of emulsifying agent, liposoluble substance B, liquid aliphatic hydrophily lipid of containing
Thing, the liquid aliphatic is in oleic acid, linoleic acid, leukotrienes, medium chain triglyceride, middle long chain fatty acids, diglyceride
One or more, content of the liquid aliphatic in hydrophily lipid composite are more than 45% with weight ratio meter, and emulsifying agent is hydrophilic
Content in property lipid composite is using weight ratio meter as 0.05%~8%, and preferred emulsifier is in hydrophily lipid composite
Content using weight ratio meter as 0.1%~6%, contents of the liposoluble substance B in hydrophily lipid composite using weight ratio meter as
0.01%~30%, preferably contents of the liposoluble substance B in hydrophily lipid composite using weight ratio meter as 0.04%~
25%;
Wherein, the liposoluble substance B is lutein ester;
The liposoluble substance B is lutein;
The liposoluble substance B is Co-Q10;
The liposoluble substance B is carrotene;
The liposoluble substance B is astaxanthin;
The liposoluble substance B is lycopene;
Or the liposoluble substance B is isoflavones.
Emulsifying agent of the present invention is selected from following one or more materials:Phosphatide, sucrose fatty ester, list, diglycerol fat
Fat acid esters, polyglyceryl fatty acid ester, methyl glycol fatty acid ester, lactic acid fatty glyceride, polysorbas20, polysorbate40, polysorbate60, tell
Temperature 80, span 20, span 40, sorbester p18, sorbester p38, sorbester p17;Wherein content of the emulsifying agent in hydrophily lipid composite
Using weight ratio meter as 0.05%~8%, content of the preferred emulsifier in hydrophily lipid composite is using weight ratio meter as 0.1%
~6%;
Preferably, in the hydrophily lipid composite, content of the emulsifying agent in hydrophily lipid composite is with weight ratio meter
For 0.07%~7%;
Preferably, in the hydrophily lipid composite, content of the emulsifying agent in hydrophily lipid composite is with weight ratio meter
For 0.1%~6%;
Preferably, in the hydrophily lipid composite, content of the emulsifying agent in hydrophily lipid composite is with weight ratio meter
For 0.2%~5%;
Preferably, in the hydrophily lipid composite, content of the emulsifying agent in hydrophily lipid composite is with weight ratio meter
For 0.3%~4%;
Preferably, in the hydrophily lipid composite, content of the emulsifying agent in hydrophily lipid composite is with weight ratio meter
For 0.35%~2.5%;
Preferably, in the hydrophily lipid composite, content of the emulsifying agent in hydrophily lipid composite is with weight ratio meter
For 0.4%~3.5%;
Preferably, in the hydrophily lipid composite, content of the emulsifying agent in hydrophily lipid composite is with weight ratio meter
For 0.5%~3%;
Preferably, in the hydrophily lipid composite, content of the emulsifying agent in hydrophily lipid composite is with weight ratio meter
For 0.6%~2.5%;
Preferably, in the hydrophily lipid composite, content of the emulsifying agent in hydrophily lipid composite is with weight ratio meter
For 0.75%~2%;
Preferably, in the hydrophily lipid composite, content of the emulsifying agent in hydrophily lipid composite is with weight ratio meter
For 0.8%~1.8%;
Preferably, in the hydrophily lipid composite, content of the emulsifying agent in hydrophily lipid composite is with weight ratio meter
For 0.85%~1.7%;
Preferably, in the hydrophily lipid composite, content of the emulsifying agent in hydrophily lipid composite is with weight ratio meter
For 0.9%~1.6%;
Preferably, in the hydrophily lipid composite, content of the emulsifying agent in hydrophily lipid composite is with weight ratio meter
For 0.95%~1.5%;
Preferably, in the hydrophily lipid composite, content of the emulsifying agent in hydrophily lipid composite is with weight ratio meter
For 1.0%~1.4%;
Preferably, in the hydrophily lipid composite, content of the emulsifying agent in hydrophily lipid composite is with weight ratio meter
For 0.4%~1.6%;
Preferably, in the hydrophily lipid composite, content of the emulsifying agent in hydrophily lipid composite is with weight ratio meter
For 0.5%~1.5%;
Preferably, in the hydrophily lipid composite, content of the emulsifying agent in hydrophily lipid composite is with weight ratio meter
For 0.6%~1.4%;
Preferably, in the hydrophily lipid composite, content of the emulsifying agent in hydrophily lipid composite is with weight ratio meter
For 0.7%~1.3%;
Preferably, in the hydrophily lipid composite, content of the emulsifying agent in hydrophily lipid composite is with weight ratio meter
For 0.8%~1.2%.
Wherein, the emulsifying agent also includes its various model, specification, the degree of polymerization, esterification degree, mono-/bis-ester, or it is included
Monomer component.Specifically, phosphatide includes but is not limited to lecithin, phosphatidyl-ethanolamine, phosphatidylinositols or phosphatidyl glycerol, it is excellent
Choosing, the content of the lecithin (i.e. phosphatidyl choline) in the phosphatide more than 40%, lecithin in preferably described phosphatide
Content is more than 50%;It is preferred that the content of the lecithin in the phosphatide is more than 60%;Sucrose fatty ester includes but is not limited to it
S-1 to S-16 various models;Single, diglycerine fatty acid ester includes but is not limited to single, bi-tristearin, list, double oleic acid
Glyceride, list, dilaurate glyceride, list, dilinoleic acid glyceride, list, double glyceryl linolenates, list, double palmitic acids
Ester, list, double Compritol 888 ATOs;Polyglyceryl fatty acid ester includes but is not limited to polyglycerol stearate, Unigly GO 102S, gathered
Glycerol monolaurate, the dimer of polyglyceryl myristate or POGE-A, trimer, tetramer, hexamer, nine
Polymers, etc., such as including but not limited to three polyglycerol stearates, three Unigly GO 102Ss, three polyglyceryl laurates, three
Polyglyceryl myristate, three POGE-As, four polyglycerol stearates, four Unigly GO 102Ss, the four polyglycereol moons
Cinnamic acid ester, four polyglyceryl myristates, four POGE-As, two polyglycerol stearates, two Unigly GO 102Ss, two
Polyglyceryl laurate, two polyglyceryl myristates, two POGE-As, six polyglycerol stearates, nine polyglycereol
Stearate, etc.;It is hard that methyl glycol fatty acid ester includes but is not limited to propylene glycol oleate, propane diols linoleate, propane diols
Resin acid ester, etc.;Lactic acid fatty glyceride includes but is not limited to oleic acid, linoleic acid, stearic acid, linolenic lactic acid glycerine
Ester, etc..
Preferably, the emulsifying agent is phosphatide, and wherein content of the phosphatide in hydrophily lipid composite is with weight ratio meter
For 0.2%~3.5%, preferably content of the phosphatide in hydrophily lipid composite is using weight ratio meter as 0.4%~2.5%.
Preferably, the emulsifying agent is selected from phosphatide and following one or more materials:Sucrose fatty ester, list, diglycerol
Fatty acid ester, polyglyceryl fatty acid ester, methyl glycol fatty acid ester, lactic acid fatty glyceride, polysorbas20, polysorbate40, polysorbate60,
Tween 80, span 20, span 40, sorbester p18, sorbester p38, sorbester p17;Wherein emulsifying agent containing in hydrophily lipid composite
Amount using weight ratio meter as 0.1%~4%, content of the preferred emulsifier in hydrophily lipid composite using weight ratio meter as
0.2%~3%.
Preferably, the emulsifying agent includes sucrose fatty ester and following one or more materials:Phosphatide, list, diglycerol
Fatty acid ester, polyglyceryl fatty acid ester, methyl glycol fatty acid ester, lactic acid fatty glyceride, polysorbas20, polysorbate40, polysorbate60,
Tween 80, span 20, span 40, sorbester p18, sorbester p38, sorbester p17;Wherein emulsifying agent containing in hydrophily lipid composite
Amount using weight ratio meter as 0.06%~5%, content of the preferred emulsifier in hydrophily lipid composite using weight ratio meter as
0.3%~3%.
Preferably, the emulsifying agent includes single, diglycerine fatty acid ester and following one or more materials:Phosphatide, sucrose
Fatty acid ester, polyglyceryl fatty acid ester, methyl glycol fatty acid ester, lactic acid fatty glyceride, polysorbas20, polysorbate40, polysorbate60,
Tween 80, span 20, span 40, sorbester p18, sorbester p38, sorbester p17;Wherein emulsifying agent containing in hydrophily lipid composite
Amount using weight ratio meter as 0.06%~5%, content of the preferred emulsifier in hydrophily lipid composite using weight ratio meter as
0.3%~3%.
Preferably, the emulsifying agent includes polyglyceryl fatty acid ester and following one or more materials:Phosphatide, sucrose fat
Acid esters, list, diglycerine fatty acid ester, methyl glycol fatty acid ester, lactic acid fatty glyceride, polysorbas20, polysorbate40, polysorbate60,
Tween 80, span 20, span 40, sorbester p18, sorbester p38, sorbester p17;Wherein emulsifying agent containing in hydrophily lipid composite
Amount using weight ratio meter as 0.06%~5%, content of the preferred emulsifier in hydrophily lipid composite using weight ratio meter as
0.3%~3%.
Preferably, the emulsifying agent includes methyl glycol fatty acid ester and following one or more materials:Phosphatide, sucrose fat
Acid esters, polyglyceryl fatty acid ester, list, diglycerine fatty acid ester, lactic acid fatty glyceride, polysorbas20, polysorbate40, polysorbate60,
Tween 80, span 20, span 40, sorbester p18, sorbester p38, sorbester p17;Wherein emulsifying agent containing in hydrophily lipid composite
Amount using weight ratio meter as 0.06%~5%, content of the preferred emulsifier in hydrophily lipid composite using weight ratio meter as
0.3%~3%.
Preferably, the emulsifying agent includes lactic acid fatty glyceride and following one or more materials:Phosphatide, Sucrose Fatty Acid Ester
Fat acid esters, polyglyceryl fatty acid ester, list, diglycerine fatty acid ester, methyl glycol fatty acid ester, polysorbas20, polysorbate40, polysorbate60,
Tween 80, span 20, span 40, sorbester p18, sorbester p38, sorbester p17;Wherein emulsifying agent containing in hydrophily lipid composite
Amount using weight ratio meter as 0.06%~5%, content of the preferred emulsifier in hydrophily lipid composite using weight ratio meter as
0.3%~3%.
Specifically, it is preferred that content of the emulsifying agent of the present invention in hydrophily lipid composite using weight ratio meter as
0.05%th, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%,
0.8%th, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%,
2%th, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.1%, 3.2%,
3.3%th, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%,
4.6%th, 4.7%, 4.8%, 4.9%, 5%, 5.1%, 5.2%, 5.3%, 5.4%, 5.5%, 5.6%, 5.7%, 5.8%,
5.9%th, 6%, 6.1%, 6.2%, 6.3%, 6.4%, 6.5%, 6.6%, 6.7%, 6.8%, 6.9%, 7%, 7.1%,
7.2%th, 7.3%, 7.4%, 7.5%, 7.6%, 7.7%, 7.8%, 7.9% or 8%.
Preferably, the content of the lecithin (i.e. phosphatidyl choline) in phosphatide of the present invention, preferably phosphatide is more than 40%,
It is preferred that the content of the lecithin in the phosphatide is more than 50%;It is preferred that the content of the lecithin in the phosphatide is more than 60%.
Specifically, it is preferred that the phosphatide is selected from soybean lecithin, soybean lecithin, yolk phospholipid, egg yolk lecithin or krill
Oil.
Further, in the lipid composite of the invention, other fat-soluble work(of one or more can also be contained
Can composition, such as nervonic acid (NA), DHA (docosahexaenoic acid), EPA (eicosapentaenoic acid),
Arachidonic acid, vitamin E, CLA, conjugated linoleic acid glyceride, phosphatidylserine, phytosterol, phytosterol
Ester, plant stanol ester or Polyene Phosphatidylcholine.
Further, in hydrophily lipid composite of the present invention, the composition that can be improved containing taste such as wraps
Include but be not limited to flavorant or flavoring essence, sweetener, such as steviol glycoside, glycyrrhizin, Sucralose, etc..
Hydrophily lipid composite of the present invention, there is outstanding hydrophily, it shakes in water fluid through shaking,
Homogeneous, stable emulsion can quickly be formed;
Or hydrophily lipid composite of the present invention, there is outstanding hydrophily, it is in the water fluid containing ethanol
In, shaken through shaking, can quickly form homogeneous, stable emulsion.
Water fluid of the present invention, including water, water content are more than 60% liquid, or the aqueous solution containing ethanol.
Rolling of the present invention of shaking, refers to the operating method by vibrating, rocking or rock, mixture is produced in a reservoir
Quick flowing, rolling or/and the motion of collision impact, mixture is set to produce rolling of shaking with hand including the use of person, or, using machine
Operation makes mixture produce rolling of shaking, for example with the operation of manipulator.
Liquid aliphatic of the present invention, including the aliphatic acid or grease of liquid are presented at normal temperatures and pressures, preferably include
Saturated or undersaturated aliphatic acid, saturation or undersaturated grease, the triglycerides of saturated or undersaturated aliphatic acid, saturation or
The diglyceride of undersaturated aliphatic acid, such as including but not limited to oleic acid, linoleic acid, alpha-linolenic acid, gamma-Linolenic acid, middle chain
Triglycerides, diglyceride, middle long chain fatty acids, etc..
Emulsion is a complicated, thermodynamic stable system, especially different types of fats or fat-soluble ingredient, by
Different in the fat-water distribution and combination energy state of each component, the stability for whole system is vital, multi-component fat
Newborn system, it is easy to the wild effects such as fat floating, flocculation or layering, production method and technique occur, decide emulsion
The form and size of middle fat globule, and the microphenomenons such as aggregation whether can occur, so as to influence the fat of emulsion in macroscopic aspect
Fat floating, flocculation or layering etc. are unstable, in addition, also contributing to emulsion digesting and assimilating and utilizing to human body.
However, disadvantageously, after emulsifying agent mixes with liquid aliphatic and fat-soluble ingredient, in normal temperature or slightly below normal temperature
Under environment, grease can be become cloudy by being long placed in, such as phosphatide can separate out precipitation, have a strong impact on the quality of product.Inventor is by grinding
The reason for studying carefully, such a phenomenon occurs is due to that emulsifying agent is not easy to produce blending effect, example with liquid aliphatic and liposoluble substance
Freezing point such as phosphatide is higher than the freezing point of vegetable oil so that the phosphatide that can not be blended with liquid aliphatic and liposoluble substance,
Precipitation can be separated out at a temperature of less than its freezing point, so as to cause grease to become cloudy, or phosphatide can separate out precipitation.
Therefore, the preparation method of hydrophily lipid composite of the present invention is vital that inventor has found, by adding
Heat, mixed at high speed make emulsifying agent and vegetable oil generation blending, state of dissolving each other, and are allowed to be evenly distributed, and further quickly, precisely drop
Temperature, or form the miscible composition of oil-gas, makes emulsifier molecules in rapid cooling, in emulsified dose point of high dispersion state
Son can form the colloidal solution of small molecule crystallite state, reach the stable mixture of emulsifying agent and vegetable oil.
Further, the present invention provides a kind of preparation method of above-mentioned hydrophily lipid composite, and it includes:
(1) dispensing:Emulsifying agent, liquid aliphatic, other liposoluble substances are weighed by formula, is settled to required output, stirring is mixed
Splitting or integrating dissipates uniform;
(2) liquid prepared in (1) is placed in emulsion tank, heating makes fluid temperature be more than 45 DEG C, big in speed of agitator
Under conditions of 500r/min, speed of agitator is preferable over more than under conditions of 1000r/min, is stirred 3~25min of operation,
Then rapidly by liquid cooling to less than 25 DEG C in 3~5min, stop stirring, stand;Or the liquid that will be prepared in (1)
Body is placed in emulsion tank, and heating makes fluid temperature be more than 45 DEG C, and the homogeneous that pressure is 20~58MPa is carried out in homogenizer,
Then rapidly by liquid cooling to less than 25 DEG C in 3~5min, stirring is stopped;
(3) it is filling:Oily liquids is subjected to vacuum outgas, it is filling, sealing, packaging, examine, produce hydrophily lipid group of the present invention
Compound.
Hydrophily lipid composite prepared by the above method of the present invention, generally in faint yellow to russet clear oil
Thing.Further, hydrophily lipid composite and water fluid are shaken to be deployed into emulsion by shaking.
For hydrophily lipid composite of the present invention, compatibility, dispersiveness with water fluid are most important
, the preparation method of composition miscible using oil-gas of the invention, produced altogether in liquid aliphatic for emulsifying agent
It is mixed, and all there is good raising to act on for the hydrophily of lipid composite.Further, the invention provides hydrophily
Second of preparation method of lipid composite, it includes:
(1) dispensing:Emulsifying agent, liquid aliphatic, other liposoluble substances are weighed by formula, is settled to required output, stirring is mixed
Splitting or integrating dissipates uniform;
(2) liquid prepared in (1) is placed in emulsion tank, nitrogen is continually fed into oily liquids or keeps emulsion tank
In pressure be more than 1.3 atmospheric pressure, and be stirred 3~25min of operation under conditions of speed of agitator is more than 300r/min, make
The grease thing of the foam type rich in nitrogen of nontransparent shape is presented in oily liquids, stops stirring;
(3) it is filling:The oily liquids prepared in (2) is filling in container, optionally container is carried out to be filled with nitrogen, and make appearance
Gas pressure intensity is more than 1.2 atmospheric pressure in device, pressurizing window, packaging, examines, produces hydrophily lipid composite.
Hydrophily lipid composite prepared by the above method of the present invention, is the foam type grease thing containing nitrogen, is presented non-
Transparence, the visible wherein bubble containing fine uniform is estimated, or foam-like is presented in the grease of liquid.Further, by parent
Aqueous lipid composition is shaken to be deployed into emulsion with water fluid by shaking.
Further, the present invention provides the preparation method of the hydrophily lipid composite described in the third, and it includes:
(1) dispensing:Emulsifying agent, liquid aliphatic, other liposoluble substances are weighed by formula, it is stand-by;
(2) liquid aliphatic and liposoluble substance are mixed, stirring, its mixing is uniformly dispersed, obtain the mixing of liposoluble substance
Thing;
(3) premixing of emulsifying agent:Take the mixing of the liposoluble substance prepared in (2) of 3~7 times of emulsifying agent and emulsifying agent weight
Thing, it is placed in emulsion tank, nitrogen is continually fed into oily liquids or keeps the pressure in emulsion tank to be more than 1.3 atmospheric pressure,
And stirred under conditions of speed of agitator is more than 300r/min, make oily liquids that the foam type rich in nitrogen of nontransparent shape be presented
Grease thing, or grease present foam-like, stop stirring;
(4) pre-mixed material of the emulsifying agent prepared in (3) is placed in emulsion tank, adds the mixed of remaining liposoluble substance
Compound, nitrogen is continually fed into oily liquids or keeps the pressure in emulsion tank to be more than 1.3 atmospheric pressure, and in speed of agitator
More than being stirred under conditions of 300r/min, make oily liquids that the foam type grease thing rich in nitrogen of nontransparent shape be presented, stop
Stirring;
(5) it is filling:The oily liquids prepared in (4) is filling in container, optionally container is carried out being filled with nitrogen and make appearance
Gas pressure intensity is more than 1.2 atmospheric pressure in device, pressurizing window, packaging, examines, produces hydrophily lipid composite.Further, will
Hydrophily lipid composite is shaken to be deployed into emulsion with water fluid by shaking.
Another aspect, the present invention provides one kind and contains emulsifying agent, liposoluble substance and liquid aliphatic hydrophily lipid
Composition, it is characterised in that be made of the first above-mentioned preparation method, second of preparation method or the third preparation method.
Further, the present invention provides a kind of hydrophily lipid composite of foam type, contains liquid of the present invention
Fat, liposoluble substance B, emulsifying agent and nitrogen, the emulsifying agent are selected from following one or more materials:Phosphatide, sucrose fat
Acid esters, list, diglycerine fatty acid ester, polyglyceryl fatty acid ester, methyl glycol fatty acid ester, lactic acid fatty glyceride, polysorbas20,
Polysorbate40, polysorbate60, Tween 80, span 20, span 40, sorbester p18, sorbester p38, sorbester p17, wherein emulsifying agent are in hydrophily fat
Content in based composition is using weight ratio meter as 0.1%~7%;The liquid aliphatic is selected from following one or more materials:Oil
Acid, linoleic acid, leukotrienes, medium chain triglyceride, diglyceride, middle long chain fatty acids, wherein liquid aliphatic is in hydrophily lipid
Content in composition is more than 45% with weight ratio meter;The liposoluble substance B is selected from following one or more materials:Lutein
Ester, lutein, Co-Q10, carrotene, astaxanthin, lycopene, isoflavones, wherein liposoluble substance B is in hydrophily
Content in lipid composite is using weight ratio meter as 0.01%~30%, and preferably liposoluble substance B is in hydrophily lipid composite
In content using weight ratio meter as 0.03%~20%;The leukotrienes includes alpha-linolenic acid or gamma-Linolenic acid, the middle long-chain
Aliphatic acid includes medium chain fatty acid or long chain fatty acids, and the emulsifying agent also includes its various models, specification, the degree of polymerization, esterification
Degree, mono-/bis-ester, or its monomer component for including, the content of lecithin is more than 40% in the phosphatide;It is preferred that the emulsifying agent choosing
From phosphatide and following one or more materials:Sucrose fatty ester, list, diglycerine fatty acid ester, polyglyceryl fatty acid ester, the third two
Alcohol fatty acid ester, lactic acid fatty glyceride, polysorbas20, polysorbate40, polysorbate60, Tween 80, span 20, span 40, sorbester p18,
Sorbester p38, sorbester p17;Wherein content of the emulsifying agent in hydrophily lipid composite is using weight ratio meter as 0.1%~4%, preferably
Content of the emulsifying agent in hydrophily lipid composite is using weight ratio meter as 0.2%~3%;Its preparation method uses above-mentioned second
The preparation method or the third preparation method of kind.
Inventor surprisingly has found, hydrophily lipid composite provided by the invention, in water fluid, is shaken through shaking, can
Quick or moment forms emulsion, for example, by the operation for rolling of shaking, hydrophily lipid composite of the present invention and water fluid are existed
Mixed in the container of closing, such as in the beverage bottle using bottle cap closing, hydrophily lipid composite is holding with water fluid
Cumulative volume in device is not higher than 98% volume space of container total capacity, by way of hand shakes rolling, rolling 1~3 of acutely shaking
Secondary, lipid composite of the present invention and water fluid can form emulsion at once, the emulsion stand 5min, or even 10min with
On, homogeneous, stable emulsion is still kept, user's allotment is very easy to and eats;In addition, the hydrophily lipid combines
Thing and water fluid are allocated to form emulsion after, even if after standing and being layered through the long period, through slight wobble, can still disperse
For emulsion, can't influence to drink or eat.Inventor is by lipid composite provided by the invention and water fluid in rolling of shaking
Under effect, moment forms the process or technology of emulsion, is referred to as " oil-water wink mixes ".
It should be noted that whether observation emulsion is layered, it is so that the liquid level that lipid material swims in water fluid occurs
On, and it is standard to form lipid material clearly released state occur with water fluid;In addition, in observation, it shall be noted that area
Bubble present on the liquid level of other emulsion or foam and the essential distinction of emulsion layering;Generally, hydrophily lipid of the present invention
Composition is forming emulsion with water fluid through cross to shake rolling, can all produce the bubble or foam of emulsion, and caused
Bubble or floatation of foam are on the liquid level of emulsion, but the bubble of this floating or foam are not that emulsion is layered, this
One phenomenon is it is noted that difference.
Further, the invention provides combined containing emulsifying agent, liposoluble substance and liquid aliphatic hydrophily lipid
The application method of thing, it includes adding hydrophily lipid composite in water fluid, is shaken through shaking, form it into emulsion and enter
One step uses, for example, it is preferable to which conduct is orally drunk, enteron aisle pipe watches use;
Or further, the present invention provides the application method of described hydrophily lipid composite, it is included institute of the present invention
After the hydrophily lipid composite stated mixes with water fluid, shaken in the container of closing by shaking, become emulsion;
Wherein, the water fluid includes the liquid of water, water content more than 60%, or the aqueous solution containing ethanol;It is described to shake
Shake, the frequency of at least 1 time rolling of shaking preferably was carried out in 1 second, and the time for rolling of shaking is no less than 1 second.
Further, the invention provides combined containing emulsifying agent, liposoluble substance and liquid aliphatic hydrophily lipid
The method that thing mixes with water fluid and is deployed into emulsion, including by lipid composite with being shaken after water fluid mixture
Shake and form emulsion, the water fluid includes the liquid of water, water content more than 60%, or the aqueous solution containing ethanol.
On the other hand, it is provided by the invention to be combined containing emulsifying agent, liposoluble substance and liquid aliphatic hydrophily lipid
Thing, there is quick water emulsification performance, preferably by the hydrophilic lipid composite of the present invention and be deployed into milkiness using allotment bottle
Liquid, particularly, the method as the fast deployment of hydrophily lipid composite and water fluid into emulsion in the following manner:Will
Hydrophily lipid composite is poured into allotment bottle with water fluid, wherein the weight ratio of water fluid and hydrophily lipid composite
More than 3:1, the weight ratio of preferably water fluid and hydrophilic lipid composite is more than 10:1, such as preferred water fluid and parent
The weight ratio of aqueous lipid composition is (10~300):1, the cumulative volume of hydrophily lipid composite and water fluid is not surpassed
The 98% of allotment bottle capacity is crossed, tightens the lid of allotment bottle, will allocate bottle with hand or manipulator shakes at least 1 time in being shaken in 1 second
Frequency, make allotment bottle shake rolling be no more than 10 seconds, especially make allotment bottle shake rolling be no more than 5 seconds, allotment bottle shake rolling when, allotment
The distance of each displacement of bottle is not less than 10 centimetres, and moves the remaining space of mixed liquor to allotment bottle, preferably makes mixed liquor
Moved to the remaining space of allotment bottle and impact the lid of allotment bottle, you can form homogeneous emulsion, the emulsion is in room temperature
Lower standing 5min keeps homogeneous milkiness liquid status, is not layered;The allotment bottle, including vial with cover, modeling with cover
Bottle, aluminium with cover-modeling carton, canister with cover are expected, for example, macromolecule PET bottle, polyethylene bottle, etc.;It is preferred that allocate bottle
Volume be not more than 3 liters, most preferably allocate bottle volume be not more than 3 liters, preferably allocate bottle volume for 2.5 liters, 1.5 liters, 1
Rise, 0.9 liter, 0.8 liter, 0.7 liter, 0.6 liter, 0.5 liter, 0.45 liter, 0.4 liter, 0.3 liter, 0.2 liter, 0.15 liter, 0.1 liter, 0.09
Rise, 0.08 liter, 0.07 liter, 0.06 liter, 0.05 liter or 0.04 liter, etc.;The water fluid includes water, water content is more than 60%
Liquid, or the aqueous solution containing ethanol.
The present invention contains emulsifying agent, liposoluble substance and liquid aliphatic hydrophily lipid composite, has unexpected
Quick water emulsification performance, be used for bringing great convenience and novel sense.
Hydrophily lipid composite of the present invention is shaken by shaking, can rapidly or moment scattered in water forms milkiness
Liquid, there is quick hydrophilic characteristic.Further, the invention provides described hydrophily lipid composite fast deployment into breast
The technical scheme of turbid.A kind of hydrophily lipid composite containing liquid aliphatic, liposoluble substance B and emulsifying agent, the breast
Agent is selected from following one or more materials:Phosphatide, sucrose fatty ester, list, diglycerine fatty acid ester, polyglycerol fatty acid
Ester, methyl glycol fatty acid ester, lactic acid fatty glyceride, polysorbas20, polysorbate40, polysorbate60, Tween 80, span 20, span 40,
The content of sorbester p18, sorbester p38, sorbester p17, wherein emulsifying agent in hydrophily lipid composite using weight ratio meter as 0.05%~
8%, content of the preferred emulsifier in hydrophily lipid composite is using weight ratio meter as 0.1%~6%;The liquid aliphatic choosing
From following one or more materials:Oleic acid, linoleic acid, alpha-linolenic acid, gamma-Linolenic acid, medium chain triglyceride, diglyceride, in
The content of long chain fatty acids, wherein liquid aliphatic in hydrophily lipid composite is more than 45% with weight ratio meter;The liposoluble
Property substance B is selected from following one or more materials:Lutein ester, lutein, Co-Q10, carrotene, astaxanthin, tomato red
Element, isoflavones, wherein contents of the liposoluble substance B in hydrophily lipid composite using weight ratio meter as 0.01%~
30%, it is characterised in that hydrophily lipid composite and water fluid are shaken by shaking, emulsion can be formed within 5 seconds,
And the emulsion that is formed stands at least 1min, can keep homogeneous milkiness liquid status, not be layered, wherein water fluid with
The weight ratio of hydrophilic lipid composite is more than 3:1, the weight ratio of preferably water fluid and hydrophilic lipid composite is big
In 10:1;
The water fluid, including:Water, water content are more than 60% liquid, or the aqueous solution containing ethanol;
The rolling of shaking, refers to the operating method by vibrating, rocking or rock, and mixture is produced motion, rolling in a reservoir
Or/and the motion of collision impact, such as mixed liquor is moved to the remaining space of container, preferably make residue of the mixed liquor to container
Spatial movement and the lid for impacting allotment bottle, mixture is set to produce rolling of shaking with hand including the use of person, or, made using machine operation
Mixture produces rolling of shaking, for example with the operation of manipulator;
The speed of the rolling of shaking, the frequency of at least 1 time rolling of shaking, and the distance of each displacement of container were preferably carried out in 1 second
Not less than 10 centimetres;
The middle long chain fatty acids include medium chain fatty acid or long chain fatty acids;
Preferably, contents of the liposoluble substance B in hydrophily lipid composite is using weight ratio meter as 0.01%~30%;
Preferably, it is characterised in that hydrophily lipid composite and water fluid are shaken by shaking, breast can be formed within 4 seconds
Turbid;
Preferably, it is characterised in that hydrophily lipid composite and water fluid are shaken by shaking, breast can be formed within 3 seconds
Turbid;
Preferably, it is characterised in that hydrophily lipid composite and water fluid are shaken by shaking, breast can be formed within 2 seconds
Turbid;
Preferably, it is characterised in that hydrophily lipid composite and water fluid are shaken by shaking, breast can be formed within 1 second
Turbid.
Hydrophily lipid composite of the present invention, belongs to lard type composition, for easy to use, more preferable absorption,
Hydrophily lipid composite of the present invention is formed into emulsion in water base liquid to be very important.For example, this is sent out
The bright healthy food or beverage mate for providing described hydrophily lipid composite as various water base liquid foods, preferably
As homogenate diet, milk, beverage, the aqueous solution, fruit juice, coffee, liquid food, such as gruel, rice paste, batter, reconstituted food, wheat is such as reconstituted
Piece, soaking milk powder, reconstitute coffee, reconstitute solid beverage, etc.;Used it is preferred that being deployed into emulsion using water fluid.
Further, invention further provides contain hydrophily lipid composite of the present invention and water fluid
Packaging compositions, the packaging compositions method that is deployed into emulsion.
A kind of packaging compositions, including hydrophily lipid composite is independently packed and combined one with water fluid
Rise, the hydrophily lipid composite contains liquid aliphatic, liposoluble substance B and emulsifying agent, and wherein liquid aliphatic is selected from following
One or more materials:Medium chain triglyceride, alpha-linolenic acid, gamma-Linolenic acid, diglyceride, oleic acid, linoleic acid, middle long-chain fat
Fat acid, content of the liquid aliphatic in hydrophily lipid composite are more than 45% with weight ratio meter;
Liposoluble substance B is selected from following one or more materials:Lutein ester, lutein, Co-Q10, carrotene, astaxanthin,
Lycopene, isoflavones, contents of the liposoluble substance B in hydrophily lipid composite using weight ratio meter as 0.01%~
30%;
Emulsifying agent is selected from following one or more materials:Phosphatide, sucrose fatty ester, list, diglycerine fatty acid ester, polyglycerol ester
Fat acid esters, methyl glycol fatty acid ester, lactic acid fatty glyceride, polysorbas20, polysorbate40, polysorbate60, Tween 80, span 20, department
Disk 40, sorbester p18, sorbester p38, sorbester p17, content of the emulsifying agent in hydrophily lipid composite is using weight ratio meter as 0.05%
~8%;
The water fluid, 60% liquid, or the aqueous solution containing ethanol are more than selected from water, water content;
The weight ratio of the water fluid and hydrophily lipid composite is more than 3:1;
The volume summation of the water fluid and hydrophily lipid composite is not more than the container capacity of receiving water fluid
98%.
Specifically, various combinations provided by the invention, the hydrophily fat of specific composition, proportioning, preparation method, concocting method
Based composition, the hydrophily lipid composite suitable for above-mentioned packaging compositions.
The packaging compositions, including hydrophily lipid composite of the present invention is independently wrapped with water fluid
Fill and combine, such as combine in same packing box or packaging bag, such as, by the independence bag of lipid composite
The form that dress fixed or packed external member by pasting fixed, label with the independent packaging of water fluid combines the formation bag together with
Fill composition, described " form for fixing or packing external member by pasting fixed, label is combined ", refer to by adhesive tape or
The modes such as sticky glue combine the independent packaging of lipid composite and the independent packaging of water fluid;Or with lipid group
The Product labelling of compound, the Product labelling of water fluid, by active forces such as the binding of label, parcel, windings, lipid is combined
The independent packaging of thing and the independent packaging of water fluid are combined;Or by the independent packaging of lipid composite and water base fluid
The independent packaging of body is arranged to pack the mode of external member, combines or fits together, for example, being set on the container of water fluid
One groove, form packaging external member by the packing material card of lipid composite in a groove, or lipid composite is independent sealed
In the chamber of the The lid component of container, water fluid is sealed in container, and the The lid component of container is arranged on opening for container
Container is sealed at mouthful so that lipid composite is each independent sealed with water fluid, when in use, by the lid structure of container
Part is opened, and is discharged the lipid composite in The lid component, is mixed with the water fluid in container, further, is shaken by shaking and shape
Into homogeneous emulsion;For example, the The lid component of described container, refers to be similar to international publication WO2007/129126 institutes public affairs
The technical scheme opened.
Or in the packaging compositions, including by hydrophily lipid composite independent packaging of the present invention, and with
Allotment bottle is present in same packaging housing unit simultaneously, and the allotment bottle is the empty bottle with lid, preferably allocates on bottle indicating
The graduation mark of the amount in need for adding water fluid, in use, only need the packing material opening of hydrophily lipid composite, will
Hydrophily lipid composite is poured into allotment bottle, adds water fluid, to facilitate allotment, rolling of shaking, makes aliphatic acid composition very
Homogeneous emulsion is formed in water fluid well and is used, is also convenient for the hydrophily lipid group that user decides addition in its sole discretion
The amount of the amount of compound and the water fluid added.
Or special situation is, packaging compositions of the present invention, in the packaging compositions, can not adjust
With bottle, but it is labeled with the label of the packing material of hydrophily lipid composite and passes through the lipid composite with water fluid
Mix in a reservoir and by mixed liquor shake and shake and obtain the content information of emulsion, and the bag of lipid composite of the present invention
Fill the technology contents of composition, i.e. hydrophily lipid composite, and be labeled with its Product labelling and combine hydrophily lipid
Thing shakes with the mixed merga pass of water fluid to shake and obtains the content of emulsion.
Combination, storage of the above-mentioned packaging compositions more convenient for lipid composite and water fluid, are more beneficial for lipid group
The allotment of compound and water fluid uses, the method that described hydrophily lipid composite is deployed into emulsion with water fluid,
Including:Hydrophily lipid composite is added in the container for accommodating water fluid, wherein water fluid and hydrophily lipid
The weight ratio of composition is more than 3:1, the cumulative volume of hydrophily lipid composite and water fluid is no more than container capacity
98%, the lid of container is tightened, bottle will be allocated in the frequency of shaking at least 1 time of being shaken in 1 second with hand or manipulator, container is shaken rolling
No more than 10 seconds, container shake rolling when, the distance of each displacement of container is not less than 10 centimetres, and makes mixed liquor to the surplus of container
Complementary space move and form emulsion, preferably container shake rolling when, mixed liquor is moved to the remaining space of container and impact allotment
The lid of bottle;
Wherein hydrophily lipid composite includes any one hydrophily lipid composite of the present invention;
The water fluid, 60% liquid, or the aqueous solution containing ethanol are more than selected from water, water content;
The container of the water fluid, selected from vial with cover, plastic bottle with cover, aluminium with cover-modeling carton, gold with cover
Belong to container, and the volume of container is not more than 3 liters.
Specifically, to include but is not limited to water, the aqueous solution of carbohydrate (such as single for water fluid of the present invention
Sugar, disaccharide, oligosaccharide, polysaccharide etc.), the aqueous solution (such as inulin, FOS, polydextrose), the dietary fiber of dietary fiber
Aqueous suspension, the aqueous solution of amino acid, the aqueous solution of vitamin, (such as potassium chloride, magnesium sulfate is water-soluble for the aqueous solution of electrolyte
Liquid), the aqueous solution of probiotics or suspension, animal emulsion (such as milk, goat milk, mare's milk), animal albumen powder aqueous emulsion (such as
Milk powder, the aqueous emulsion of goat milk powder, the aqueous emulsion of refined lactoprotein powder), the aqueous emulsion (soybean protein of plant protein powder
The aqueous emulsion of powder, peanut protein powder), liquid juice, liquid vegetable juice, the aqueous extract of plant, plant extracts it is water-soluble
Liquid or water suspension (such as water suspension of the aqueous solution of tealeaves or coffee, tealeaves or coffee), homogenate diet, ethanol water are (as drunk
With wine, beer, cocktail), etc..
Preferably, water fluid of the present invention is selected from the aqueous solution of following one or more materials:Sucrose, glucose,
It is fructose, maltose, chitosan oligosaccharide, FOS, xylo-oligosaccharide, polydextrose, inulin, taurine, cysteine, cystine, sweet
Propylhomoserin, aspartic acid, asparagine, glutamic acid, glutamine, lysine, arginine, ornithine, vitamin C, vitamin B,
L-cn, folic acid, nicotinic acid, choline, inositol;Or, it is preferred that water fluid of the present invention is selected from animal emulsion, animal
The aqueous emulsion of albumen powder or the aqueous emulsion of plant protein powder.
Above-mentioned preferable water fluid, on the one hand, water-soluble or protide functional materials are provide not only, with this hair
The hydrophily lipid composite of bright offer has the pharmacological action of Synergistic, and on the other hand, above-mentioned water fluid is more beneficial for
With hydrophily lipid composite is quick under rolling effect of shaking forms emulsion, and keep good, the emulsion that is not easy to be layered
Stability.
Present invention also offers described hydrophily lipid composite be applied to medicine, special medicine purposes formula food,
Health food, nutraceutical or cosmetics, etc., on the one hand, contain in the hydrophily lipid composite to health and
The unrighted acid and fats health ingredients of rehabilitation effect, are particularly suitable for use in and prepare medicine, special medicine purposes is matched somebody with somebody
Square food, health food, nutraceutical or cosmetics, on the other hand, hydrophily lipid composite of the invention belong to liquid,
Grease type solvent can be used as, fat-soluble medicine is dissolved and can further be allocated, is dispersed in shape in water fluid
Use, in favor of the oral of fat-soluble medicine, absorption and utilize, for example, fat-soluble medicine includes A Defu into emulsion
Wei ester, tenofovir disoproxil, liposoluble vitamin, etc..In addition, when being used for cosmetics, as moisturizing essential oil, heal-care essential oil, shield
Send out essential oil, or be dissolved in water as face, the moisturizing of skin, repairing cosmetics, and skin-nourishing oil breast, etc., for pair
Nursing and beauty of skin, etc..Particularly, hydrophily lipid composite of the present invention, as ready-mixed oil is drunk, can drink
With the health such as healthy oil, health care, nutrition treatment product.Particularly, the homogenate diet of special medicine purposes formula food is being prepared
In application.
Therefore, present invention also offers the hydrophily lipid group containing the liquid aliphatic, liposoluble substance and emulsifying agent
Compound is further shaken to be deployed into emulsion by being mixed with water fluid by shaking, and is preparing or allocating medicine, special doctor
The application in terms of purposes formula food, health food, nutraceutical or cosmetics is learned, is especially orally taken the photograph immediately in preparation or allotment
Application in the medicine that enters, special medicine purposes formula food, health food, nutraceutical, or it is instant preparing or allocating
Application in the cosmetics used, greatly facilitate the instant allotment of user, use immediately.
Present invention also offers the hydrophily lipid composite containing liquid aliphatic, liposoluble substance and emulsifying agent by with
Water fluid mix, through shake shake and be prepared into the application in emulsion.
Present invention also offers the hydrophily lipid composite containing liquid aliphatic, liposoluble substance and emulsifying agent by with
Water fluid mix, and further through shake shake and be deployed into emulsion, preparing the even of special medicine purposes formula food food
Starch the application in meals.
On the one hand, hydrophily lipid composite of the present invention, can provide beneficial for health and disease treatment
Unrighted acid, such as alpha-linolenic acid, gamma-Linolenic acid, etc., and fat-soluble medicine or nutriment, such as medium chain triglyceride
Three esters, lutein ester, lutein, Co-Q10, carrotene, astaxanthin, lycopene, isoflavones, etc.;The opposing party
Face, emulsifying agent and liposoluble substance of the present invention have good pharmacology synergy, for health, especially in oral supplementation
Phosphatide, unrighted acid and fat-soluble medicine etc., there is good synergy.Therefore, further, it is of the invention
Additionally provide containing emulsifying agent and liquid aliphatic hydrophily lipid composite by being mixed with water fluid, through shake shake and prepare
Into the emulsion for being available for orally drinking, the application in terms of the medicine or Special food of preventing and treating cardiovascular and cerebrovascular disease is prepared;Making
Application in terms of standby oxidation resistant medicine or Special food;In terms of medicine or Special food that unrighted acid is provided is prepared
Application;Or the application in terms of the fat-soluble medicine of offer or Special food are provided.
Hydrophily lipid composite of the present invention, it is deployed into the process of emulsion, for consumers, a side
Face, it is a kind of enjoyment, oil-based materials and water-based material is especially changed into milkiness by the rolling process of shaking of one or two second, moment
Liquid, drastically increases the desire of user, this from formulated product or the process used, caused psychological desire contribute to
The intake of the material of health-nutrition of the present invention;On the other hand, by hydrophily lipid composite of the present invention and the process of water allotment, it is
It is a kind of to start, beat one's brains and the process with eye, oil-based materials and water-based material are especially passed through into the rolling process of shaking of one or two second, wink
Between be changed into emulsion, drastically increase the desire drunk or fed of consumer, it is this from the process for allocating diet, it is produced
Psychological desire contribute to health-nutrition of the present invention oil-based materials intake;In addition, the mistake of this rolling of shaking (vibrate and rock)
Journey can discharge pressure, and what this process was brought is a kind of pleasant mood, optimize diet mood, this state being in a cheerful frame of mind
Contribute to healthy diet, the effect for not only facilitating the oil-based materials of health-nutrition of the present invention plays, can more improve to beverage or
Drink rate is abandoned in the amount of homogenate diet, reduction, is reduced and is wasted and pollute.
Hydrophily lipid composite provided by the invention, the product preparing mode that oil-water quickly mutually melts is realized, there is weight
Big meaning.For beverage or homogenate diet, oil-based materials are independently packed with water-based material, and by both independent packaging groups
It is combined, both is quickly mixed by way of shaking and shaking allotment when in use and form emulsion, this method causes
Oil-based materials each independently preserve with water fluid and significantly improve respective stability, without adding emulsion stabilizing agent,
Avoid unrighted acid and other liposoluble substances are degraded in water-bearing media, greatly improve the stabilization of product
Property, quality is ensure that, also extend shelf life or shelf-life, be advantageous to the quality assurance and circulation of commodity.On the other hand, this hair
The hydrophily lipid composite of bright offer can quickly leach in water and form homogeneous, stable emulsion, it is easy to operation and
Prepared by canteen, by the rolling that mixes, shakes, homogeneous emulsion can be formed in 1~5 second, is advantageous to lipid composite and water base fluid
Quick, the convenient allotment of body, there is allotment, the advantages of using immediately immediately, be also beneficial to liposoluble constituent oral absorption and
Utilize, greatly facilitate the instant allotment of user, use immediately.
Further healthy meaning is hydrophily lipid composite provided by the invention, liquid aliphatic and fat-soluble thing
Matter B has pharmacology synergy, can not only bring the more health fat of user, such as medium chain triglyceride, unsaturation
The health such as fat, phosphatide, nutrition, the material of disease prevention and cure class, also provide lutein ester, lutein, Co-Q10, carrot
The liposoluble substance B such as element, astaxanthin, lycopene, isoflavones, there is good pharmacology to cooperate with health, disease prevention and cure
Effect.
It should be understood that, oral preparation needs that by the absorption of intestines and stomach blood of human body could be entered to reach physiology work
With, the quality of oral absorption, the therapeutic effect of medicine is directly affected.According to the concept of pharmacy, bioavilability
(Bioavailability) refer to preparation to be rapidly absorbed into sanguimotor producing level and utilize speed.
Hydrophily lipid composite and its concocting method of the present invention, solve the shortcomings of prior art, have following
Advantage:1st, grease-like composition, not aqueous, stability is good;2nd, there is outstanding hydrophily, can be mixed with water and disperse to form milkiness
Liquid, be advantageous to edible and easy to operation;3rd, allotment is convenient, fast, by rolling of shaking in a reservoir, can be formed in 1~5 second homogeneous
Emulsion, allocate or make the mood for bringing pleasure to diet, help to discharge pressure and healthy diet, optimize diet feelings
Thread;4th, functional fatty acid and liposoluble substance B bioavilability are improved;5th, the emulsion formed has preferable stabilization
Property, more than 5min is stood, homogeneous, stable emulsion can be kept;6th, the emulsion formed is after being long placed in and being layered, through light
It is micro- to rock, homogeneous emulsion can be still formed, is advantageous to user and drinks or be orally ingested by phased manner.
It is fast in water base liquid containing emulsifying agent, liposoluble substance compared to the preparation of other non-emulsified liquid types, the present invention
Speed forms emulsion, has excellent water-oily dissolution characteristics, is being inhaled for the oral formulations using liposoluble substance as active ingredient
Take in into terms of sanguimotor degree and speed, there is significant facilitation and meaning, this life for liposoluble substance
The raising of thing availability is significant.The absorption process that preparation enters after stomach and intestine, in two stages, i.e., scattered and gastrointestinal wall
Absorb two stages, scatter firstly the need of in gastric juice or intestinal juice, then contact again and be attached to gastrointestinal wall absorbed and
Into blood, the two stages can all influence the liposoluble substance of unrighted acid and other healthy functions absorb and
The performance of health benefit, liposoluble substance is prepared as the good emulsion of water dispersible, the dissolution of liposoluble substance and point
Scattered speed is dramatically speeded up, substantially increase it in gastric juice or intestinal juice disperse degree and rate of dispersion, make liposoluble substance with
The contact of gastrointestinal wall is more abundant, and the active ingredient for being attached to Gastrointestinal Wall Absorption and entering blood is also more abundant, and this is for liposoluble
The raising of the bioavilability of property material is significant.For example, lutein ester, lutein, Co-Q10, carrotene, shrimp
Blue or green element, lycopene, isoflavones, medium chain triglyceride, alpha-linolenic acid, gamma-Linolenic acid etc. pass through parent provided by the invention
Aqueous lipid composition is deployed into emulsion with water fluid and drunk, and its bioavilability (Bioavailability) substantially changes
It is kind, there is highly significant effect.
For embodiment in the implementation process of the present invention, those of ordinary skill in the art are not departing from the model of the present invention
Enclose is obvious and is easy to perform with caused various embodiments and modification on the basis of Spirit Essence.Pass through
The following examples are further elaborated with come application to the present invention etc., it is not intended that limit of the embodiment to the present invention
System.
Embodiment 1, hydrophilic lipid composite, its preparation and concocting method, it is applied in combination.
Hydrophilic lipid composite, recipe quantity by weight percentage, contain respectively:
Wherein, the phosphatide is selected from soybean lecithin, soybean lecithin, yolk phospholipid, egg yolk lecithin or krill oil.
Its preparation method one, including:
(1) dispensing:By formula weigh emulsifying agent, liquid aliphatic, other liposoluble substances respectively, as lutein ester, Co-Q10,
Beta carotene, astaxanthin, lycopene or isoflavones, required output is settled to, is stirred, is uniformly dispersed, or
Person, other liposoluble substances are first added into liquid aliphatic and it is dissolved completely in liquid aliphatic, add emulsifying agent, stirring is mixed
Splitting or integrating dissipates uniform;
(2) liquid prepared in (1) is placed in emulsion tank, heating makes fluid temperature be more than 45 DEG C, big in speed of agitator
Under conditions of 500r/min, be stirred 3~25min of operation, then in 3~5min rapidly by liquid cooling to 25 DEG C with
Under, stop stirring, stand;Or the liquid prepared in (1) is placed in emulsion tank, heating make fluid temperature for 45 DEG C with
On, in homogenizer carry out pressure be 20~58MPa homogeneous, then in 3~5min rapidly by liquid cooling to 25 DEG C with
Under, stop stirring;
(3) it is filling:Oily liquids is subjected to vacuum outgas, it is filling, sealing, packaging, examine, produce.
Or its preparation method two, including:
(1) dispensing:By formula weigh emulsifying agent, liquid aliphatic, other liposoluble substances respectively, as lutein ester, Co-Q10,
Beta carotene, astaxanthin, lycopene or isoflavones, required output is settled to, is stirred, is uniformly dispersed, or
Person, other liposoluble substances are first added into liquid aliphatic and it is dissolved completely in liquid aliphatic, add emulsifying agent, stirring is mixed
Splitting or integrating dissipates uniform;
(2) liquid prepared in (1) is placed in emulsion tank, nitrogen is continually fed into oily liquids or keeps emulsion tank
In pressure be more than 1.3 atmospheric pressure, and be stirred 3~25min of operation under conditions of speed of agitator is more than 300r/min, make
The foam type grease thing rich in nitrogen of nontransparent shape is presented in oily liquids, stops stirring;
(3) it is filling:The oily liquids prepared in (2) is filling in container, further container is carried out to be filled with nitrogen, and make appearance
Gas pressure intensity is more than 1.2 atmospheric pressure in device, pressurizing window, packaging, examines, produces.
Or its preparation method three, including:
(1) dispensing:Emulsifying agent, liquid aliphatic, other liposoluble substances are weighed respectively by formula, it is stand-by;
(2) liquid aliphatic and other liposoluble substances are mixed, stirring, its mixing is uniformly dispersed, obtain liposoluble substance
Mixture, or, first by other liposoluble substances, as lutein ester, Co-Q10, beta carotene, astaxanthin, lycopene or
Isoflavones, add liquid aliphatic and it is dissolved completely in liquid aliphatic, be stirred, be uniformly dispersed;
(3) premixing of emulsifying agent:Take the mixing of the liposoluble substance prepared in (2) of 3~7 times of emulsifying agent and emulsifying agent weight
Thing, it is placed in emulsion tank, nitrogen is continually fed into oily liquids or keeps the pressure in emulsion tank to be more than 1.3 atmospheric pressure,
And stirred under conditions of speed of agitator is more than 300r/min, make oily liquids that the foam type rich in nitrogen of nontransparent shape be presented
Foam-like is presented in grease thing, or grease, stops stirring;
(4) pre-mixed material of the emulsifying agent prepared in (3) is placed in emulsion tank, adds the mixed of remaining liposoluble substance
Compound, nitrogen is continually fed into oily liquids or keeps the pressure in emulsion tank to be more than 1.3 atmospheric pressure, and in speed of agitator
More than being stirred under conditions of 300r/min, make oily liquids that the foam type grease thing rich in nitrogen of nontransparent shape be presented, stop
Stirring;
(5) it is filling:The oily liquids prepared in (4) is filling in container, further container is carried out being filled with nitrogen and make appearance
Gas pressure intensity is more than 1.2 atmospheric pressure in device, pressurizing window, packaging, examines, produces.
Fast deployment performance:The hydrophily lipid composite that any one in the present embodiment matches is poured into water fluid
Allocate in bottle, the weight ratio of wherein water fluid and hydrophilic lipid composite is more than 10:1, make hydrophily lipid composite
It is no more than the 98% of allotment bottle capacity with the cumulative volume of water fluid, tightens the lid of allotment bottle, will be allocated with hand or manipulator
Bottle shakes the frequency of at least 1 time in being shaken in 1 second, allotment bottle is shaken rolling at most 5 seconds, allotment bottle shake rolling when, allocate each position of bottle
The distance of shifting is not less than 10 centimetres, and moves the remaining space of mixed liquor to allotment bottle, preferably makes mixed liquor to allotment bottle
Remaining space move and impact allotment bottle lid, as stated above, you can form homogeneous emulsion, the emulsion is in room
The lower standing 5min of temperature is still in homogeneous emulsion, is not layered;The allotment bottle, be vial with cover, plastic bottle with cover,
Aluminium with cover-modeling carton, canister with cover, for example, macromolecule PET bottle, polyethylene bottle, etc.;It is with cover to be to be able to
Tighten lid and shake and shake the operation of allotment, the volume for preferably allocating bottle is not more than 3 liters, such as the volume of preferred allotment bottle is
0.5 liter, the water fluid includes the liquid of water, water content more than 60%, or the aqueous solution containing ethanol, such as the water
Base fluid body is selected from the aqueous solution of following one or more materials:Sucrose, glucose, fructose, maltose, chitosan oligosaccharide, FOS,
Xylo-oligosaccharide, polydextrose, inulin, taurine, cysteine, cystine, glycine, aspartic acid, asparagine, paddy ammonia
Acid, glutamine, lysine, arginine, ornithine, vitamin C, vitamin B, l-cn, folic acid, nicotinic acid, choline, flesh
Alcohol.
Embodiment 2, hydrophilic lipid composite, it is prepared and concocting method.
Hydrophilic lipid composite, recipe quantity by weight percentage, contain respectively:
Wherein, the phosphatide is selected from soybean lecithin, soybean lecithin, yolk phospholipid, egg yolk lecithin or krill oil;Alpha-linolenic acid
Donor plant grease separation from linseed oil, Purple Perilla Seed Oil, pumpkin seed oil, peony seed oil, eucommia ulmoides seed oil or oil and fat of sacha inchi;γ-Asia
The donor grease separation of numb acid is oily from gamma-linolenic acid oil, evening primrose oil, blackcurrant oil, borage;Linoleic donor plant grease separation
From soybean oil, corn oil, peanut oil, sunflower oil, olive oil, silybum marianum seed oil, pumpkin seed oil, amygdalus pedunculata pall oil, palm oil,
Sesame oil, Semen Juglandis oil, rapeseed oil, safflower seed oil, grape-kernel oil, rice bran oil, Suaeda salsa seed oil, wheat-germ oil, corn
Embryo oil, pine-seed oil, hemp-seed oil, smooth bark Lai wood fruit oil, rhus glabra oil, peony seed oil, samara oil, imperial rice bran oil, Tomato Seed
Oil, Fructus Zanthoxyli oil, canola, Camellia oily (including tea seed oil, camellia seed oil or tea oil), shea butter, borage oil,
Capsicum seed oil, coconut oil or cottonseed oil;The donor plant grease separation of oleic acid is from soybean oil, corn oil, peanut oil, sunflower oil, olive
It is olive oil, pumpkin seed oil, silybum marianum seed oil, amygdalus pedunculata pall oil, palm oil, sesame oil, Semen Juglandis oil, evening primrose oil, rapeseed oil, red
In flower seed oil, grape-kernel oil, rice bran oil, Litsea cubeba oil, capsicum seed oil, granada seed oil, brucea fruit oil or coconut oil.
Preparation method:Its preparation method is with being preparation method one, preparation method two or the preparation method three-phase in embodiment 1
Together, the preparation method in embodiment 1 can be completely suitable for the present embodiment.
Allotment:The hydrophily lipid composite water fluid of any one proportioning is shaken to be deployed into milkiness by shaking
Liquid, preferably described water fluid are selected from the aqueous solution of following one or more materials:Sucrose, glucose, fructose, maltose, shell
Oligosaccharides, FOS, xylo-oligosaccharide, polydextrose, inulin, taurine, cysteine, cystine, glycine, aspartic acid,
Asparagine, glutamic acid, glutamine, lysine, arginine, ornithine, vitamin C, vitamin B, l-cn, folic acid,
Nicotinic acid, choline, inositol, or water fluid are selected from water, animal emulsion, the aqueous emulsion of animal albumen powder or plant protein powder
Aqueous emulsion.
Embodiment 3, hydrophilic lipid composite, it is prepared and concocting method.
Hydrophilic lipid composite, recipe quantity by weight percentage, contain respectively:
Wherein, the phosphatide includes soybean lecithin, soybean lecithin, yolk phospholipid, egg yolk lecithin or krill oil;It is linoleic
Donor plant grease separation is flat from soybean oil, corn oil, peanut oil, sunflower oil, olive oil, silybum marianum seed oil, pumpkin seed oil, long handle
Peach oil, palm oil, sesame oil, Semen Juglandis oil, rapeseed oil, safflower seed oil, grape-kernel oil, Suaeda salsa seed oil, wheat-germ oil,
Maize germ oil, pine-seed oil, hemp-seed oil, smooth bark Lai wood fruit oil, rhus glabra oil, peony seed oil, samara oil, imperial rice bran oil, kind
Eggplant seed oil, Fructus Zanthoxyli oil, canola, Camellia oily (including tea seed oil, camellia seed oil or tea oil), rice bran oil, the wooden fruit of breast
Oil, borage oil, capsicum seed oil, coconut oil or cottonseed oil;The donor plant grease separation of oleic acid from soybean oil, corn oil, peanut oil,
Sunflower oil, olive oil, pumpkin seed oil, silybum marianum seed oil, amygdalus pedunculata pall oil, palm oil, sesame oil, Semen Juglandis oil, oenothera biennis
Oil, rapeseed oil, safflower seed oil, grape-kernel oil, rice bran oil, Litsea cubeba oil, capsicum seed oil, granada seed oil, brucea fruit oil or coconut
In oil.
Preparation method:Its preparation method is with being preparation method one, preparation method two or the preparation method three-phase in embodiment 1
Together, the preparation method in embodiment 1 can be completely suitable for the present embodiment.
Allotment:The hydrophily lipid composite water fluid of any one proportioning is shaken to be deployed into milkiness by shaking
Liquid, such as preferred water fluid are selected from the aqueous solution of following one or more materials:Sucrose, glucose, fructose, maltose, shell
Oligosaccharides, FOS, xylo-oligosaccharide, polydextrose, inulin, taurine, cysteine, cystine, glycine, aspartic acid,
Asparagine, glutamic acid, glutamine, lysine, arginine, ornithine, vitamin C, vitamin B, l-cn, folic acid,
Nicotinic acid, choline, inositol, or water fluid are selected from water, animal emulsion, the aqueous emulsion of animal albumen powder or plant protein powder
Aqueous emulsion.
Embodiment 4, hydrophilic lipid composite, it is prepared and concocting method.
Hydrophilic lipid composite, recipe quantity by weight percentage, contain respectively:
Wherein, the phosphatide is selected from soybean lecithin, soybean lecithin, yolk phospholipid, egg yolk lecithin or krill oil;Alpha-linolenic acid
Donor plant grease separation from linseed oil, Purple Perilla Seed Oil, pumpkin seed oil, peony seed oil, eucommia ulmoides seed oil or oil and fat of sacha inchi;γ-Asia
The donor grease separation of numb acid is oily from gamma-linolenic acid oil, evening primrose oil, blackcurrant oil, borage;Linoleic donor plant grease separation
From soybean oil, corn oil, peanut oil, sunflower oil, olive oil, silybum marianum seed oil, pumpkin seed oil, amygdalus pedunculata pall oil, palm oil,
Sesame oil, Semen Juglandis oil, rapeseed oil, safflower seed oil, grape-kernel oil, Suaeda salsa seed oil, wheat-germ oil, maize germ oil,
Pine-seed oil, hemp-seed oil, smooth bark Lai wood fruit oil, rhus glabra oil, peony seed oil, samara oil, imperial rice bran oil, tomato seed oil, Chinese prickly ash
Seed oil, canola, Camellia oily (including tea seed oil, camellia seed oil or tea oil), rice bran oil, shea butter, borage oil,
Capsicum seed oil, coconut oil or cottonseed oil;The donor plant grease separation of oleic acid is from soybean oil, corn oil, peanut oil, sunflower oil, olive
It is olive oil, pumpkin seed oil, silybum marianum seed oil, amygdalus pedunculata pall oil, palm oil, sesame oil, Semen Juglandis oil, evening primrose oil, rapeseed oil, red
In flower seed oil, grape-kernel oil, rice bran oil, Litsea cubeba oil, capsicum seed oil, granada seed oil, brucea fruit oil or coconut oil.
Preparation method:Its preparation method is with being preparation method one, preparation method two or the preparation method three-phase in embodiment 1
Together, the preparation method in embodiment 1 can be completely suitable for the present embodiment.
Allotment:The hydrophily lipid composite water fluid of any one proportioning is shaken to be deployed into milkiness by shaking
Liquid, such as preferred water fluid are selected from the aqueous solution of following one or more materials:Sucrose, glucose, fructose, maltose, shell
Oligosaccharides, FOS, xylo-oligosaccharide, polydextrose, inulin, taurine, cysteine, cystine, glycine, aspartic acid,
Asparagine, glutamic acid, glutamine, lysine, arginine, ornithine, vitamin C, vitamin B, l-cn, folic acid,
Nicotinic acid, choline, inositol, or water fluid are selected from the water of animal emulsion, the aqueous emulsion of animal albumen powder or plant protein powder
Emulsion.
Embodiment 5, the lipid composite containing lutein ester or lutein, it is prepared and concocting method.
Hydrophilic lipid composite, recipe quantity by weight percentage, contain respectively:
Wherein, the phosphatide is selected from soybean lecithin, soybean lecithin, yolk phospholipid, egg yolk lecithin or krill oil;Leukotrienes bag
Include alpha-linolenic acid, gamma-Linolenic acid;
Its preparation method one, including:
(1) dispensing:Lutein ester or lutein are weighed by formula, adds medium chain triglyceride, stirring makes lutein ester or leaf yellow
Element is dissolved in medium chain triglyceride, adds phosphatide, leukotrienes, linoleic acid, oleic acid, vitamin E, DHA, is stirred, disperses
Uniformly;(2) emulsification or homogeneous:The liquid prepared in (1) is placed in emulsion tank, heating makes fluid temperature be more than 45 DEG C,
Under conditions of speed of agitator is more than 500r/min, 3~25min of emulsification procedure is carried out, then rapidly by liquid in 3~5min
Less than 25 DEG C are cooled to, stops stirring, is stood;Or the liquid prepared in (1) is placed in emulsion tank, heating makes liquid
Temperature is more than 45 DEG C, is that 20~58MPa carries out homogeneous in pressure, then rapidly by liquid cooling to 25 DEG C in 3~5min
Hereinafter, stop stirring, stand;(3) it is filling:Oily liquids is subjected to vacuum outgas, it is filling, sealing, packaging, examine, produce.
Or its preparation method two, including:
Lutein ester or lutein are weighed by formula, adds medium chain triglyceride, stirring is dissolved in lutein ester or lutein
Medium chain triglyceride, phosphatide, leukotrienes, linoleic acid, oleic acid, vitamin E, DHA are added, be stirred, be uniformly dispersed;(2)
The liquid prepared in (1) is placed in emulsion tank, the pressure being continually fed into oily liquids in nitrogen or holding emulsion tank
It is powerful to make oily liquid more than 3~25min of operation is stirred under conditions of 300r/min in 1.3 atmospheric pressure, and in speed of agitator
The foam type grease thing rich in nitrogen of nontransparent shape is presented in body, stops stirring;
(3) it is filling:The oily liquids prepared in (2) is filling in container, further container is carried out to be filled with nitrogen, and make appearance
Gas pressure intensity is more than 1.2 atmospheric pressure in device, pressurizing window, packaging, examines, produces.
Allotment:The hydrophily lipid composite water fluid of any one proportioning is shaken to be deployed into milkiness by shaking
Liquid, such as preferred water fluid are selected from the aqueous solution of following one or more materials:Sucrose, glucose, fructose, maltose, shell
Oligosaccharides, FOS, xylo-oligosaccharide, polydextrose, inulin, taurine, cysteine, cystine, glycine, aspartic acid,
Asparagine, glutamic acid, glutamine, lysine, arginine, ornithine, vitamin C, vitamin B, l-cn, folic acid,
Nicotinic acid, choline, inositol, or water fluid are selected from water, animal emulsion, the aqueous emulsion of animal albumen powder or plant protein powder
Aqueous emulsion.
Embodiment 6, the lipid composite containing Co-Q10, it is prepared and concocting method.
Hydrophilic lipid composite, recipe quantity by weight percentage, contain respectively:
Wherein, the phosphatide includes soybean lecithin, soybean lecithin, yolk phospholipid or egg yolk lecithin;Linolenic donor is planted
Thing oil includes linseed oil, Purple Perilla Seed Oil, pumpkin seed oil, peony seed oil, evening primrose oil, blackcurrant oil, borage oil, hempseed
Oil, eucommia ulmoides seed oil or oil and fat of sacha inchi;Linoleic donor plant oil includes soybean oil, corn oil, peanut oil, sunflower oil, olive
Olive oil, silybum marianum seed oil, pumpkin seed oil, amygdalus pedunculata pall oil, palm oil, sesame oil, Semen Juglandis oil, rapeseed oil, safflower seed oil, Portugal
Grape seed oil, Suaeda salsa seed oil, wheat-germ oil, maize germ oil, smooth bark Lai wood fruit oil, rhus glabra oil, peony seed oil, the moon
See careless oil, blackcurrant oil, borage oil, samara oil, imperial rice bran oil, tomato seed oil, Fructus Zanthoxyli oil, canola, canola oil, Camellia
Oily (including tea seed oil, camellia seed oil or tea oil), rice bran oil, capsicum seed oil, coconut oil, granada seed oil, Litsea cubeba oil, pine
Seed oil, nut oil, hemp-seed oil, brucea fruit oil or cottonseed oil;The donor plant oil of oleic acid includes soybean oil, corn oil, peanut
Oil, sunflower oil, olive oil, pumpkin seed oil, silybum marianum seed oil, amygdalus pedunculata pall oil, palm oil, sesame oil, Semen Juglandis oil, vegetable seed
Oil, safflower seed oil, grape-kernel oil, rice bran oil, canola oil, capsicum seed oil or coconut oil;DHA donor vegetable and animals oils include DHA
Algae oil, krill oil, fish oil or fish oil extract;EPA donor vegetable and animals oils include krill oil, fish oil or fish oil extract;
Its preparation method one, including:
(1) dispensing:Co-Q10 is weighed by formula, adds liquid aliphatic, stirring makes Co-Q10 be dissolved in liquid aliphatic, added
Phosphatide, methyl glycol fatty acid ester and other liposoluble substances, are stirred, are uniformly dispersed;(2) emulsification or homogeneous:It will match somebody with somebody in (1)
The liquid made is placed in emulsion tank, and heating makes fluid temperature be more than 45 DEG C, is more than 500r/min condition in speed of agitator
Under, 3~25min of emulsification procedure is carried out, then rapidly by liquid cooling to less than 25 DEG C in 3~5min, stops stirring, it is quiet
Put;Or the liquid prepared in (1) is placed in emulsion tank, heating make fluid temperature be more than 45 DEG C, in pressure be 20~
58MPa carries out homogeneous, then rapidly by liquid cooling to less than 25 DEG C in 3~5min, stops stirring, stands;(3) it is filling:
Oily liquids is subjected to vacuum outgas, it is filling, sealing, packaging, examine, produce.
Or its preparation method two, including:
Co-Q10 is weighed by formula, adds liquid aliphatic, stirring makes Co-Q10 be dissolved in liquid aliphatic, adds phosphatide, third
Diol fatty acid ester and other liposoluble substances, are stirred, are uniformly dispersed;(2) liquid prepared in (1) is placed in emulsification
In tank, nitrogen is continually fed into oily liquids or keeps the pressure in emulsion tank to be more than 1.3 atmospheric pressure, and in speed of agitator
More than 3~25min of operation is stirred under conditions of 300r/min, make oily liquids that the bubble rich in nitrogen of nontransparent shape be presented
Foam type grease thing, stop stirring;
(3) it is filling:The oily liquids prepared in (2) is filling in container, further container is carried out to be filled with nitrogen, and make appearance
Gas pressure intensity is more than 1.2 atmospheric pressure in device, pressurizing window, packaging, examines, produces.
Allotment:The hydrophily lipid composite water fluid of any one proportioning is shaken to be deployed into milkiness by shaking
Liquid, such as preferred water fluid are selected from the aqueous solution of following one or more materials:Sucrose, glucose, fructose, maltose, shell
Oligosaccharides, FOS, xylo-oligosaccharide, polydextrose, inulin, taurine, cysteine, cystine, glycine, aspartic acid,
Asparagine, glutamic acid, glutamine, lysine, arginine, ornithine, vitamin C, vitamin B, l-cn, folic acid,
Nicotinic acid, choline, inositol, or water fluid are selected from water, animal emulsion, the aqueous emulsion of animal albumen powder or plant protein powder
Aqueous emulsion.
Embodiment 7, the lipid composite containing isoflavones, it is prepared and concocting method.
Hydrophilic lipid composite, recipe quantity by weight percentage, contain respectively:
Wherein, the phosphatide includes soybean lecithin, soybean lecithin, yolk phospholipid or egg yolk lecithin;Linolenic donor is planted
Thing oil includes linseed oil, Purple Perilla Seed Oil, pumpkin seed oil, peony seed oil, evening primrose oil, blackcurrant oil, borage oil, hempseed
Oil, eucommia ulmoides seed oil or oil and fat of sacha inchi;The donor plant oil of oleic acid includes soybean oil, corn oil, peanut oil, sunflower oil, olive
Oil, pumpkin seed oil, silybum marianum seed oil, amygdalus pedunculata pall oil, palm oil, sesame oil, Semen Juglandis oil, rapeseed oil, safflower seed oil, grape
Seed oil, rice bran oil, canola oil, capsicum seed oil or coconut oil;Linoleic donor plant oil includes soybean oil, corn oil, peanut
Oil, sunflower oil, olive oil, silybum marianum seed oil, pumpkin seed oil, amygdalus pedunculata pall oil, palm oil, sesame oil, Semen Juglandis oil, vegetable seed
Oil, safflower seed oil, grape-kernel oil, Suaeda salsa seed oil, wheat-germ oil, maize germ oil, smooth bark Lai wood fruit oil, rhus glabra
Oil, peony seed oil, evening primrose oil, blackcurrant oil, borage oil, samara oil, imperial rice bran oil, tomato seed oil, Fructus Zanthoxyli oil, mustard seeds
Oil, canola oil, Camellia oily (including tea seed oil, camellia seed oil or tea oil), rice bran oil, capsicum seed oil, coconut oil, pomegranate seed
Oil, Litsea cubeba oil, pine-seed oil, nut oil, hemp-seed oil, brucea fruit oil or cottonseed oil;The isoflavones, it is included but not
It is limited to daidzin, daidzein, genistein, genistin;
Its preparation method one, including:
(1) dispensing:Isoflavones is weighed by formula, adds liquid aliphatic, stirring makes isoflavones be dissolved in liquid aliphatic,
Phosphatide, lactic acid fatty glyceride, vitamin E are added, is stirred, is uniformly dispersed;(2) emulsification or homogeneous:It will match somebody with somebody in (1)
The liquid made is placed in emulsion tank, and heating makes fluid temperature be more than 45 DEG C, is more than 500r/min condition in speed of agitator
Under, 3~25min of emulsification procedure is carried out, then rapidly by liquid cooling to less than 25 DEG C in 3~5min, stops stirring, it is quiet
Put;Or the liquid prepared in (1) is placed in emulsion tank, heating make fluid temperature be more than 45 DEG C, in pressure be 20~
58MPa carries out homogeneous, then rapidly by liquid cooling to less than 25 DEG C in 3~5min, stops stirring, stands;(3) it is filling:
Oily liquids is subjected to vacuum outgas, it is filling, sealing, packaging, examine, produce.
Or its preparation method two, including:
Isoflavones is weighed by formula, adds liquid aliphatic, stirring makes isoflavones be dissolved in liquid aliphatic, adds phosphorus
Fat, lactic acid fatty glyceride, vitamin E, are stirred, are uniformly dispersed;(2) liquid prepared in (1) is placed in emulsification
In tank, nitrogen is continually fed into oily liquids or keeps the pressure in emulsion tank to be more than 1.3 atmospheric pressure, and in speed of agitator
More than 3~25min of operation is stirred under conditions of 300r/min, make oily liquids that the bubble rich in nitrogen of nontransparent shape be presented
Foam type grease thing, stop stirring;
(3) it is filling:The oily liquids prepared in (2) is filling in container, further container is carried out to be filled with nitrogen, and make appearance
Gas pressure intensity is more than 1.2 atmospheric pressure in device, pressurizing window, packaging, examines, produces.
Allotment:The hydrophily lipid composite water fluid of any one proportioning is shaken to be deployed into milkiness by shaking
Liquid, such as preferred water fluid are selected from the aqueous solution of following one or more materials:Sucrose, glucose, fructose, maltose, shell
Oligosaccharides, FOS, xylo-oligosaccharide, polydextrose, inulin, taurine, cysteine, cystine, glycine, aspartic acid,
Asparagine, glutamic acid, glutamine, lysine, arginine, ornithine, vitamin C, vitamin B, l-cn, folic acid,
Nicotinic acid, choline, inositol, or water fluid are selected from water, animal emulsion, the aqueous emulsion of animal albumen powder or plant protein powder
Aqueous emulsion.
Embodiment 8, the lipid composite containing lycopene, it is prepared and concocting method.
Hydrophilic lipid composite, recipe quantity by weight percentage, contain respectively:
Wherein, the phosphatide includes soybean lecithin, soybean lecithin, yolk phospholipid or egg yolk lecithin;Linolenic donor is planted
Thing oil includes linseed oil, Purple Perilla Seed Oil, pumpkin seed oil, peony seed oil, evening primrose oil, blackcurrant oil, borage oil, hempseed
Oil, eucommia ulmoides seed oil or oil and fat of sacha inchi;The donor plant oil of oleic acid includes soybean oil, corn oil, peanut oil, sunflower oil, olive
Oil, pumpkin seed oil, silybum marianum seed oil, amygdalus pedunculata pall oil, palm oil, sesame oil, Semen Juglandis oil, rapeseed oil, safflower seed oil, grape
Seed oil, rice bran oil, canola oil, capsicum seed oil or coconut oil;Linoleic donor plant oil includes soybean oil, corn oil, peanut
Oil, sunflower oil, olive oil, silybum marianum seed oil, pumpkin seed oil, amygdalus pedunculata pall oil, palm oil, sesame oil, Semen Juglandis oil, vegetable seed
Oil, safflower seed oil, grape-kernel oil, Suaeda salsa seed oil, wheat-germ oil, maize germ oil, smooth bark Lai wood fruit oil, rhus glabra
Oil, peony seed oil, evening primrose oil, blackcurrant oil, borage oil, samara oil, imperial rice bran oil, tomato seed oil, Fructus Zanthoxyli oil, mustard seeds
Oil, canola oil, Camellia oily (including tea seed oil, camellia seed oil or tea oil), rice bran oil, capsicum seed oil, coconut oil, pomegranate seed
Oil, Litsea cubeba oil, pine-seed oil, nut oil, hemp-seed oil, brucea fruit oil or cottonseed oil;DHA donor vegetable and animals oils include DHA
Algae oil, krill oil, fish oil or fish oil extract;EPA donor vegetable and animals oils include krill oil, fish oil or fish oil extract;
Its preparation method one, including:
(1) dispensing:Weigh lycopene and other liposoluble substances by formula, add liquid aliphatic, stirring make lycopene and
Other liposoluble substances are dissolved in liquid aliphatic, add phosphatide, list, diglycerine fatty acid ester, vitamin E, are stirred, divide
Dissipate uniform;(2) emulsification or homogeneous:The liquid prepared in (1) is placed in emulsion tank, heating make fluid temperature for 45 DEG C with
On, under conditions of speed of agitator is more than 500r/min, 3~25min of emulsification procedure is carried out, then rapidly will in 3~5min
Liquid cooling stops stirring to less than 25 DEG C, stands;Or the liquid prepared in (1) is placed in emulsion tank, heating makes
Fluid temperature be more than 45 DEG C, in pressure be 20~58MPa carry out homogeneous, then in 3~5min rapidly by liquid cooling extremely
Less than 25 DEG C, stop stirring, stand;(3) it is filling:Oily liquids is subjected to vacuum outgas, it is filling, sealing, packaging, examine, i.e.,
.
Or its preparation method two, including:
Lycopene and other liposoluble substances are weighed by formula, adds liquid aliphatic, stirring makes lycopene and other liposoluble
Property material is dissolved in liquid aliphatic, adds phosphatide, list, diglycerine fatty acid ester, vitamin E, is stirred, is uniformly dispersed;
(2) liquid prepared in (1) is placed in emulsion tank, nitrogen is continually fed into oily liquids or is kept in emulsion tank
Pressure is more than 1.3 atmospheric pressure, and is stirred 3~25min of operation under conditions of speed of agitator is more than 300r/min, makes oily
The foam type grease thing rich in nitrogen of nontransparent shape is presented in liquid, stops stirring;
(3) it is filling:The oily liquids prepared in (2) is filling in container, further container is carried out to be filled with nitrogen, and make appearance
Gas pressure intensity is more than 1.2 atmospheric pressure in device, pressurizing window, packaging, examines, produces.
Allotment:The hydrophily lipid composite water fluid of any one proportioning is shaken to be deployed into milkiness by shaking
Liquid, such as preferred water fluid are selected from the aqueous solution of following one or more materials:Sucrose, glucose, fructose, maltose, shell
Oligosaccharides, FOS, xylo-oligosaccharide, polydextrose, inulin, taurine, cysteine, cystine, glycine, aspartic acid,
Asparagine, glutamic acid, glutamine, lysine, arginine, ornithine, vitamin C, vitamin B, l-cn, folic acid,
Nicotinic acid, choline, inositol, or water fluid are selected from water, animal emulsion, the aqueous emulsion of animal albumen powder or plant protein powder
Aqueous emulsion.
Embodiment 9, the lipid composite containing astaxanthin, it is prepared and concocting method.
Hydrophilic lipid composite, recipe quantity by weight percentage, contain respectively:
Wherein, the phosphatide includes soybean lecithin, soybean lecithin, yolk phospholipid or egg yolk lecithin;Linolenic donor is planted
Thing oil includes linseed oil, Purple Perilla Seed Oil, pumpkin seed oil, peony seed oil, evening primrose oil, blackcurrant oil, borage oil, hempseed
Oil, eucommia ulmoides seed oil or oil and fat of sacha inchi;The donor plant oil of oleic acid includes soybean oil, corn oil, peanut oil, sunflower oil, olive
Oil, pumpkin seed oil, silybum marianum seed oil, amygdalus pedunculata pall oil, palm oil, sesame oil, Semen Juglandis oil, rapeseed oil, safflower seed oil, grape
Seed oil, rice bran oil, canola oil, capsicum seed oil or coconut oil;Linoleic donor plant oil includes soybean oil, corn oil, peanut
Oil, sunflower oil, olive oil, silybum marianum seed oil, pumpkin seed oil, amygdalus pedunculata pall oil, palm oil, sesame oil, Semen Juglandis oil, vegetable seed
Oil, safflower seed oil, grape-kernel oil, Suaeda salsa seed oil, wheat-germ oil, maize germ oil, smooth bark Lai wood fruit oil, rhus glabra
Oil, peony seed oil, evening primrose oil, blackcurrant oil, borage oil, samara oil, imperial rice bran oil, tomato seed oil, Fructus Zanthoxyli oil, mustard seeds
Oil, canola oil, Camellia oily (including tea seed oil, camellia seed oil or tea oil), rice bran oil, capsicum seed oil, coconut oil, pomegranate seed
Oil, Litsea cubeba oil, pine-seed oil, nut oil, hemp-seed oil, brucea fruit oil or cottonseed oil;DHA donor vegetable and animals oils include DHA
Algae oil, krill oil, fish oil or fish oil extract;EPA donor vegetable and animals oils include krill oil, fish oil or fish oil extract;
Its preparation method one, including:
(1) dispensing:Astaxanthin and other liposoluble substances are weighed by formula, adds liquid aliphatic, and stirring makes astaxanthin and other
Liposoluble substance is dissolved in liquid aliphatic, adds phosphatide, sucrose fatty ester, vitamin E, is stirred, is uniformly dispersed;
(2) emulsification or homogeneous:The liquid prepared in (1) is placed in emulsion tank, heating makes fluid temperature be more than 45 DEG C, in stirring
Rotating speed be more than 500r/min under conditions of, carry out 3~25min of emulsification procedure, then in 3~5min rapidly by liquid cooling extremely
Less than 25 DEG C, stop stirring, stand;Or the liquid prepared in (1) is placed in emulsion tank, heating makes the fluid temperature be
More than 45 DEG C, it is that 20~58MPa carries out homogeneous in pressure, then stops in 3~5min rapidly by liquid cooling to less than 25 DEG C
Only stir, stand;(3) it is filling:Oily liquids is subjected to vacuum outgas, it is filling, sealing, packaging, examine, produce.
Or its preparation method two, including:
Astaxanthin and other liposoluble substances are weighed by formula, adds liquid aliphatic, stirring makes astaxanthin and other fat-soluble things
Matter is dissolved in liquid aliphatic, adds phosphatide, sucrose fatty ester, vitamin E, is stirred, is uniformly dispersed;(2) by (1)
The liquid prepared is placed in emulsion tank, and nitrogen is continually fed into oily liquids or keeps the pressure in emulsion tank to be more than
1.3 atmospheric pressure, and 3~25min of operation is stirred under conditions of speed of agitator is more than 300r/min, oily liquids is presented
The foam type grease thing rich in nitrogen of nontransparent shape, stop stirring;
(3) it is filling:The oily liquids prepared in (2) is filling in container, further container is carried out to be filled with nitrogen, and make appearance
Gas pressure intensity is more than 1.2 atmospheric pressure in device, pressurizing window, packaging, examines, produces.
Allotment:The hydrophily lipid composite water fluid of any one proportioning is shaken to be deployed into milkiness by shaking
Liquid, such as preferred water fluid are selected from the aqueous solution of following one or more materials:Sucrose, glucose, fructose, maltose, shell
Oligosaccharides, FOS, xylo-oligosaccharide, polydextrose, inulin, taurine, cysteine, cystine, glycine, aspartic acid,
Asparagine, glutamic acid, glutamine, lysine, arginine, ornithine, vitamin C, vitamin B, l-cn, folic acid,
Nicotinic acid, choline, inositol, or water fluid are selected from water, animal emulsion, the aqueous emulsion of animal albumen powder or plant protein powder
Aqueous emulsion.
Embodiment 10, the lipid composite containing carrotene, it is prepared and concocting method.
Hydrophilic lipid composite, recipe quantity by weight percentage, contain respectively:
Wherein, the phosphatide includes soybean lecithin, soybean lecithin, yolk phospholipid or egg yolk lecithin;Linolenic donor is planted
Thing oil includes linseed oil, Purple Perilla Seed Oil, pumpkin seed oil, peony seed oil, evening primrose oil, blackcurrant oil, borage oil, hempseed
Oil, eucommia ulmoides seed oil or oil and fat of sacha inchi;The donor plant oil of oleic acid includes soybean oil, corn oil, peanut oil, sunflower oil, olive
Oil, pumpkin seed oil, silybum marianum seed oil, amygdalus pedunculata pall oil, palm oil, sesame oil, Semen Juglandis oil, rapeseed oil, safflower seed oil, grape
Seed oil, rice bran oil, canola oil, capsicum seed oil or coconut oil;Linoleic donor plant oil includes soybean oil, corn oil, peanut
Oil, sunflower oil, olive oil, silybum marianum seed oil, pumpkin seed oil, amygdalus pedunculata pall oil, palm oil, sesame oil, Semen Juglandis oil, vegetable seed
Oil, safflower seed oil, grape-kernel oil, Suaeda salsa seed oil, wheat-germ oil, maize germ oil, smooth bark Lai wood fruit oil, rhus glabra
Oil, peony seed oil, evening primrose oil, blackcurrant oil, borage oil, samara oil, imperial rice bran oil, tomato seed oil, Fructus Zanthoxyli oil, mustard seeds
Oil, canola oil, Camellia oily (including tea seed oil, camellia seed oil or tea oil), rice bran oil, capsicum seed oil, coconut oil, pomegranate seed
Oil, Litsea cubeba oil, pine-seed oil, nut oil, hemp-seed oil, brucea fruit oil or cottonseed oil;DHA donor vegetable and animals oils include DHA
Algae oil, krill oil, fish oil or fish oil extract;EPA donor vegetable and animals oils include krill oil, fish oil or fish oil extract;Institute
Stating carrotene includes beta carotene or alpha-carotene;
Its preparation method one, including:
(1) dispensing:Carrotene and other liposoluble substances are weighed by formula, adds liquid aliphatic, stirring makes carrotene and its
Its liposoluble substance is dissolved in liquid aliphatic, adds phosphatide, lactic acid fatty glyceride, vitamin E, is stirred, disperses
Uniformly;(2) emulsification or homogeneous:The liquid prepared in (1) is placed in emulsion tank, heating makes fluid temperature be more than 45 DEG C,
Under conditions of speed of agitator is more than 500r/min, 3~25min of emulsification procedure is carried out, then rapidly by liquid in 3~5min
Less than 25 DEG C are cooled to, stops stirring, is stood;Or the liquid prepared in (1) is placed in emulsion tank, heating makes liquid
Temperature is more than 45 DEG C, is that 20~58MPa carries out homogeneous in pressure, then rapidly by liquid cooling to 25 DEG C in 3~5min
Hereinafter, stop stirring, stand;(3) it is filling:Oily liquids is subjected to vacuum outgas, it is filling, sealing, packaging, examine, produce.
Or its preparation method two, including:
Carrotene and other liposoluble substances are weighed by formula, adds liquid aliphatic, and stirring makes carrotene and other fat-soluble
Material is dissolved in liquid aliphatic, adds phosphatide, lactic acid fatty glyceride, vitamin E, is stirred, is uniformly dispersed;(2)
The liquid prepared in (1) is placed in emulsion tank, the pressure being continually fed into oily liquids in nitrogen or holding emulsion tank
It is powerful to make oily liquid more than 3~25min of operation is stirred under conditions of 300r/min in 1.3 atmospheric pressure, and in speed of agitator
The foam type grease thing rich in nitrogen of nontransparent shape is presented in body, stops stirring;(3) it is filling:The oily liquids that will be prepared in (2)
It is filling that further container is carried out to be filled with nitrogen in container, and gas pressure intensity in container is more than 1.2 atmospheric pressure, sealing envelope
Mouthful, packaging, examine, produce.
Allotment:The hydrophily lipid composite water fluid of any one proportioning is shaken to be deployed into milkiness by shaking
Liquid, such as preferred water fluid are selected from the aqueous solution of following one or more materials:Sucrose, glucose, fructose, maltose, shell
Oligosaccharides, FOS, xylo-oligosaccharide, polydextrose, inulin, taurine, cysteine, cystine, glycine, aspartic acid,
Asparagine, glutamic acid, glutamine, lysine, arginine, ornithine, vitamin C, vitamin B, l-cn, folic acid,
Nicotinic acid, choline, inositol, or water fluid are selected from water, animal emulsion, the aqueous emulsion of animal albumen powder or plant protein powder
Aqueous emulsion.
Embodiment 11, hydrophilic the lipid composite fast deployment performance and packaged combination of embodiment 1 to embodiment 10.
The hydrophilic lipid composite that any one is matched into embodiment 10 of Example 1, has well quick
Allocate performance.
Fast deployment performance:The hydrophily lipid composite that any one in embodiment matches and water fluid are poured into tune
With in bottle, the weight ratio of wherein water fluid and hydrophilic lipid composite is more than 3:1, preferably water fluid with it is hydrophilic
The weight ratio of lipid composite is more than 10:1, the cumulative volume of hydrophily lipid composite and water fluid is no more than allotment bottle and hold
The 50% of amount, the lid of allotment bottle is tightened, will allocate bottle in the frequency of shaking at least 1 time of being shaken in 1 second with hand or manipulator, make tune
Shaken rolling at most 5 seconds with bottle, allotment bottle shake rolling when, the distance of the allotment each displacement of bottle is not less than 10 centimetres, and makes mixed liquor
Moved to the remaining space of allotment bottle, preferably move the remaining space of mixed liquor to allotment bottle and impact the lid of allotment bottle,
As stated above, you can form homogeneous emulsion, it is in still homogeneous emulsion that the emulsion stands 5min at room temperature, is not occurred
Layering;The allotment bottle, is vial with cover, plastic bottle with cover, aluminium with cover-modeling carton, canister with cover, example
Such as, macromolecule PET bottle, polyethylene bottle, etc.;It is with cover to be to be able to tighten lid and shake to shake the operation of allotment, preferably adjust
Volume with bottle is not more than 3 liters, such as the volume of preferred allotment bottle is 0.5 liter, and it is big that the aqueous-based liquid includes water, water content
In 60% liquid, or the aqueous solution containing ethanol, such as including but not limited to animal emulsion, fruit juice, beverage made of fruits or vegetables, plant
Extract solution or beverage, carbohydrate solutions or beverage, vegetable protein beverage, the aqueous emulsion of animal milk powder, amino acid it is water-soluble
Liquid, etc..
Packaged combination:A kind of packaging compositions, including the hydrophily by any one proportioning into embodiment 10 of embodiment 1
Lipid composite independent packaging, and be present in simultaneously in same packing box or same packaging bag with allotment bottle, the allotment
Bottle is the empty bottle with lid;Or the water fluid of certain volume is pre-loaded with the allotment bottle, for by aliphatic acid group
Compound is directly added into allotment bottle, is shaken by shaking to form homogeneous emulsion;Or in the packaging compositions, hydrophily lipid
The independent packaging of composition with allotment bottle is present in simultaneously in a packing box or packaging bag or by pasting admittedly
The mode that fixed, label is fixed formed assembly packaging or Packaging Bottle equipped with hydrophily lipid composite or packaging bag with
Allotment bottle is fixed together in the form of packing external member, or is contained any one in the present embodiment in the packaging compositions and matched somebody with somebody
The hydrophily lipid composite of ratio, and be embodied with its label by hydrophily lipid composite and water fluid by shake shake and
Obtain the content of emulsion.The volume summation of wherein described water fluid and hydrophily lipid composite, which is not more than, accommodates water base fluid
The container capacity of body or the 98% of allotment bottle capacity.
Packaged combination:The independent sealed lid structure in container of hydrophily lipid composite that any one in embodiment is matched
In the chamber of part, water fluid is sealed in container, and opening of the The lid component of container installed in container is entered to container
Row sealing so that lipid composite is each independent sealed with water fluid, when in use, the The lid component of container is opened, release
The lipid composite gone out in The lid component, mix with the water fluid in container, further, shaken by shaking to form homogeneous milkiness
Liquid;Or the lipid composite in the chamber of the The lid component of container is injected into water in the form of a diameter of 0.4mm~2mm fluid column
In base fluid body, such as gases at high pressure in the chamber for passing through the The lid component of container eject lipid composite, or pass through
Piston pressurization, the mode injected eject lipid composite, lipid composite is mixed with water fluid, shake and shake and formed
Emulsion, the water fluid include the liquid of water, water content more than 60%, or the aqueous solution containing ethanol.It is wherein described
Water fluid and 98% of the volume summation of hydrophily lipid composite no more than the container capacity for accommodating water fluid.
The hydrophily lipid composite of any proportioning, takes 1 gram of hydrophily lipid in embodiment 12, embodiment 1~10
Composition, 2~150 milliliters of water fluid is added, shaken through shaking, in 5 seconds, or even emulsion can be formed in 1 second, and
It and the emulsion of formation is being stored at room temperature more than 5min, can keep being stabilized, can keep homogeneous, stably, it is existing that layering does not occur
As;
Or hydrophily lipid composite and water fluid are poured into allotment bottle, the water of its reclaimed water or water content more than 60%
The weight ratio of base fluid body and hydrophilic lipid composite is more than 3:1, preferably water fluid and hydrophilic lipid composite
Weight ratio is more than 10:1, the cumulative volume of hydrophily lipid composite and water fluid is no more than the 70% of allotment bottle capacity, twist
The lid of tight allotment bottle, bottle will be allocated in the frequency of shaking at least 2 times of being shaken in 1 second with hand or manipulator, allotment bottle is shaken rolling extremely
More 5 seconds, allotment bottle shake rolling when, the distance of allotment bottle each displacement is not less than 10 centimetres, and makes mixed liquor to allotment bottle
Remaining space moves, and preferably moves the remaining space of mixed liquor to allotment bottle and impacts the lid of allotment bottle, as stated above,
Homogeneous emulsion can be formed, it is in still homogeneous emulsion that the emulsion stands 5min at room temperature, is not layered;The tune
Can be vial with cover, plastic bottle with cover, aluminium with cover-modeling carton, canister with cover with bottle.
Claims (18)
1. the hydrophily lipid composite containing liquid aliphatic, liposoluble substance B and emulsifying agent, the liquid aliphatic is selected from following
One or more materials:Oleic acid, linoleic acid, leukotrienes, medium chain triglyceride, diglyceride, wherein middle long chain fatty acids, liquid
Content of the fat in hydrophily lipid composite is more than 45% with weight ratio meter;
The emulsifying agent is selected from following one or more materials:Phosphatide, sucrose fatty ester, list, it is diglycerine fatty acid ester, poly- sweet
Oil and fat acid esters, methyl glycol fatty acid ester, lactic acid fatty glyceride, polysorbas20, polysorbate40, polysorbate60, Tween 80, sapn
20th, the content of span 40, sorbester p18, sorbester p38, sorbester p17, wherein emulsifying agent in hydrophily lipid composite is with weight ratio meter
For 0.05%~8%;
The liposoluble substance B is selected from following one or more materials:Lutein ester, lutein, Co-Q10, carrotene, shrimp
Blue or green element, lycopene, isoflavones, wherein contents of the liposoluble substance B in hydrophily lipid composite is with weight ratio meter
For 0.01%~30%;
The leukotrienes includes alpha-linolenic acid or gamma-Linolenic acid, and the carrotene includes beta carotene or alpha-carotene, institute
Stating middle long chain fatty acids includes medium chain fatty acid or long chain fatty acids.
2. hydrophily lipid composite according to claim 1, the liquid aliphatic is selected from medium chain triglyceride and following
One or more materials:Oleic acid, linoleic acid, alpha-linolenic acid, gamma-Linolenic acid, diglyceride, middle long chain fatty acids, wherein middle chain
Content of the triglycerides in hydrophily lipid composite is using weight ratio meter as 10%~99%.
3. hydrophily lipid composite according to claim 1, the liquid aliphatic be selected from leukotrienes and it is following a kind of or
Many kinds of substance:Oleic acid, linoleic acid, medium chain triglyceride, diglyceride, middle long chain fatty acids, wherein leukotrienes is in hydrophily fat
Content in based composition is using weight ratio meter as 1%~99%;The leukotrienes includes alpha-linolenic acid or gamma-Linolenic acid.
4. hydrophily lipid composite according to claim 1, the emulsifying agent is selected from phosphatide and following one or more
Material:Sucrose fatty ester, list, diglycerine fatty acid ester, polyglyceryl fatty acid ester, methyl glycol fatty acid ester, lactic acid aliphatic acid
Glyceride, polysorbas20, polysorbate40, polysorbate60, Tween 80, span 20, span 40, sorbester p18, sorbester p38, sorbester p17;It is wherein newborn
Content of the agent in hydrophily lipid composite is using weight ratio meter as 0.2%~3%.
5. hydrophily lipid composite according to claim 1, the content of the lecithin in the phosphatide is more than 40%.
6. the preparation method of the hydrophily lipid composite described in claim 1, it includes:
(1) dispensing:Emulsifying agent, liquid aliphatic, other liposoluble substances are weighed by formula, is settled to required output, stirring is mixed
Splitting or integrating dissipates uniform;
(2) liquid prepared in (1) is placed in emulsion tank, heating makes fluid temperature be more than 45 DEG C, big in speed of agitator
Under conditions of 500r/min, be stirred 3~25min of operation, then in 3~5min rapidly by liquid cooling to 25 DEG C with
Under, stop stirring, stand;Or the liquid prepared in (1) is placed in emulsion tank, heating make fluid temperature for 45 DEG C with
On, in homogenizer carry out pressure be 20~58MPa homogeneous, then in 3~5min rapidly by liquid cooling to 25 DEG C with
Under, stop stirring;
(3) it is filling:Oily liquids is subjected to vacuum outgas, it is filling, sealing, packaging, examine, produce;
Or its preparation method, it includes:
(1) dispensing:Emulsifying agent, liquid aliphatic, other liposoluble substances are weighed by formula, is settled to required output, stirring is mixed
Splitting or integrating dissipates uniform;
(2) liquid prepared in (1) is placed in emulsion tank, nitrogen is continually fed into oily liquids or keeps emulsion tank
In pressure be more than 1.3 atmospheric pressure, and be stirred 3~25min of operation under conditions of speed of agitator is more than 300r/min, make
The grease thing of the foam type rich in nitrogen of nontransparent shape is presented in oily liquids, stops stirring;
(3) it is filling:Will(2)The oily liquids of middle preparation is filling in container, further container is carried out to be filled with nitrogen, and make appearance
Gas pressure intensity is more than 1.2 atmospheric pressure in device, pressurizing window, packaging, examines, produces;
Or its preparation method, it includes:
(1)Dispensing:Emulsifying agent, liquid aliphatic, other liposoluble substances are weighed by formula, it is stand-by;
(2)Liquid aliphatic and liposoluble substance are mixed, stirring, its mixing is uniformly dispersed, obtain the mixing of liposoluble substance
Thing;
(3)The premixing of emulsifying agent:Take 3~7 times of emulsifying agent and emulsifying agent weight(2)The mixing of the liposoluble substance of middle preparation
Thing, it is placed in emulsion tank, nitrogen is continually fed into oily liquids or keeps the pressure in emulsion tank to be more than 1.3 atmospheric pressure,
And stirred under conditions of speed of agitator is more than 300r/min, make oily liquids that the foam type rich in nitrogen of nontransparent shape be presented
Grease thing, stop stirring;
(4)The pre-mixed material of the emulsifying agent prepared in (3) is placed in emulsion tank, adds the mixed of remaining liposoluble substance
Compound, nitrogen is continually fed into oily liquids or keeps the pressure in emulsion tank to be more than 1.3 atmospheric pressure, and in speed of agitator
More than being stirred under conditions of 300r/min, make oily liquids that the foam type grease thing rich in nitrogen of nontransparent shape be presented, stop
Stirring;
(5) it is filling:Will(4)The oily liquids of middle preparation is filling in container, further container is carried out being filled with nitrogen and makes appearance
Gas pressure intensity is more than 1.2 atmospheric pressure in device, pressurizing window, packaging, examines, produces.
7. the method that the hydrophily lipid composite described in claim 1 mixes with water fluid and is deployed into emulsion, including:
Hydrophily lipid composite and water fluid are poured into allotment bottle, wherein the weight of water fluid and hydrophily lipid composite
Than more than 3:1, the cumulative volume of hydrophily lipid composite and water fluid is no more than the 98% of allotment bottle capacity, tighten allotment
The lid of bottle, bottle will be allocated in the frequency of shaking at least 1 time of being shaken in 1 second with hand or manipulator, the rolling of shaking of allotment bottle is no more than 10
Second, the allotment bottle shake rolling when, the distance of allotment bottle each displacement is not less than 10 centimetres, and makes mixed liquor to allotment bottle
Remaining space moves, you can forms homogeneous emulsion;
The allotment bottle, including vial with cover, plastic bottle with cover, aluminium with cover-modeling carton, canister with cover,
And the volume for allocating bottle is not more than 3 liters;
The water fluid includes the liquid of water, water content more than 60%, or the aqueous solution containing ethanol.
8. a kind of packaging compositions, including hydrophily lipid composite is independently packed and combined one with water fluid
Rise, the hydrophily lipid composite contains liquid aliphatic, liposoluble substance B and emulsifying agent, and wherein liquid aliphatic is selected from following
One or more materials:Medium chain triglyceride, alpha-linolenic acid, gamma-Linolenic acid, diglyceride, oleic acid, linoleic acid, middle long-chain fat
Fat acid, content of the liquid aliphatic in hydrophily lipid composite are more than 45% with weight ratio meter;
Liposoluble substance B is selected from following one or more materials:Lutein ester, lutein, Co-Q10, carrotene, astaxanthin,
Lycopene, isoflavones, contents of the liposoluble substance B in hydrophily lipid composite using weight ratio meter as 0.01%~
30%;
Emulsifying agent is selected from following one or more materials:Phosphatide, sucrose fatty ester, list, diglycerine fatty acid ester, polyglycerol ester
Fat acid esters, methyl glycol fatty acid ester, lactic acid fatty glyceride, polysorbas20, polysorbate40, polysorbate60, Tween 80, span 20, department
Disk 40, sorbester p18, sorbester p38, sorbester p17, content of the emulsifying agent in hydrophily lipid composite using weight ratio meter as 0.05%~
8%;
The water fluid, 60% liquid, or the aqueous solution containing ethanol are more than selected from water, water content;
The weight ratio of the water fluid and hydrophily lipid composite is more than 3:1;
The volume summation of the water fluid and hydrophily lipid composite is not more than the container capacity of receiving water fluid
98%。
9. packaging compositions according to claim 8, the liquid aliphatic be selected from medium chain triglyceride and it is following a kind of or
Many kinds of substance:Oleic acid, linoleic acid, alpha-linolenic acid, gamma-Linolenic acid, diglyceride, middle long chain fatty acids, wherein medium chain triglyceride three
Content of the ester in hydrophily lipid composite is using weight ratio meter as 10%~99%.
10. packaging compositions according to claim 8, the liquid aliphatic is selected from leukotrienes and following one or more
Material:Oleic acid, linoleic acid, medium chain triglyceride, diglyceride, middle long chain fatty acids, wherein leukotrienes are in hydrophily lipid group
For content in compound using weight ratio meter as 1%~99%, the leukotrienes includes alpha-linolenic acid or gamma-Linolenic acid.
11. packaging compositions according to claim 8, the emulsifying agent is selected from phosphatide and following one or more materials:
Sucrose fatty ester, list, diglycerine fatty acid ester, polyglyceryl fatty acid ester, methyl glycol fatty acid ester, lactic acid fatty acid glycerine
Ester, polysorbas20, polysorbate40, polysorbate60, Tween 80, span 20, span 40, sorbester p18, sorbester p38, sorbester p17, wherein emulsifying agent
Content in hydrophily lipid composite is using weight ratio meter as 0.2%~3%.
12. packaging compositions according to claim 8, the content of the lecithin in the phosphatide is more than 40%.
13. packaging compositions according to claim 8, the water fluid is selected from the water-soluble of following one or more materials
Liquid:Sucrose, glucose, fructose, maltose, chitosan oligosaccharide, FOS, xylo-oligosaccharide, polydextrose, inulin, taurine, half Guang
Propylhomoserin, cystine, glycine, aspartic acid, asparagine, glutamic acid, glutamine, lysine, arginine, ornithine, dimension
Raw plain C, vitamin B, l-cn, folic acid, nicotinic acid, choline, inositol;Or the water fluid is selected from animal emulsion, animal
The aqueous emulsion of albumen powder or the aqueous emulsion of plant protein powder.
14. packaging compositions according to claim 8, the hydrophily lipid composite is prepared using following methods:It
Including:(1) dispensing:Emulsifying agent, liquid aliphatic, other liposoluble substances are weighed by formula, is settled to required output, stirring is mixed
Splitting or integrating dissipates uniform;
(2) liquid prepared in (1) is placed in emulsion tank, heating makes fluid temperature be more than 45 DEG C, big in speed of agitator
Under conditions of 500r/min, be stirred 3~25min of operation, then in 3~5min rapidly by liquid cooling to 25 DEG C with
Under, stop stirring, stand;Or the liquid prepared in (1) is placed in emulsion tank, heating make fluid temperature for 45 DEG C with
On, in homogenizer carry out pressure be 20~58MPa homogeneous, then in 3~5min rapidly by liquid cooling to 25 DEG C with
Under, stop stirring;
(3) it is filling:Oily liquids is subjected to vacuum outgas, it is filling, sealing, packaging, examine, produce;
Or its preparation method, it includes:
(1) dispensing:Emulsifying agent, liquid aliphatic, other liposoluble substances are weighed by formula, is settled to required output, stirring is mixed
Splitting or integrating dissipates uniform;
(2) liquid prepared in (1) is placed in emulsion tank, nitrogen is continually fed into oily liquids or keeps emulsion tank
In pressure be more than 1.3 atmospheric pressure, and be stirred 3~25min of operation under conditions of speed of agitator is more than 300r/min, make
The grease thing of the foam type rich in nitrogen of nontransparent shape is presented in oily liquids, stops stirring;
(3) it is filling:Will(2)The oily liquids of middle preparation is filling in container, further container is carried out to be filled with nitrogen, and make appearance
Gas pressure intensity is more than 1.2 atmospheric pressure in device, pressurizing window, packaging, examines, produces;
Or its preparation method, it includes:
(1)Dispensing:Emulsifying agent, liquid aliphatic, other liposoluble substances are weighed by formula, it is stand-by;
(2)Liquid aliphatic and liposoluble substance are mixed, stirring, its mixing is uniformly dispersed, obtain the mixing of liposoluble substance
Thing;
(3)The premixing of emulsifying agent:Take 3~7 times of emulsifying agent and emulsifying agent weight(2)The mixing of the liposoluble substance of middle preparation
Thing, it is placed in emulsion tank, nitrogen is continually fed into oily liquids or keeps the pressure in emulsion tank to be more than 1.3 atmospheric pressure,
And stirred under conditions of speed of agitator is more than 300r/min, make oily liquids that the foam type rich in nitrogen of nontransparent shape be presented
Grease thing, stop stirring;
(4)The pre-mixed material of the emulsifying agent prepared in (3) is placed in emulsion tank, adds the mixed of remaining liposoluble substance
Compound, nitrogen is continually fed into oily liquids or keeps the pressure in emulsion tank to be more than 1.3 atmospheric pressure, and in speed of agitator
More than being stirred under conditions of 300r/min, make oily liquids that the foam type grease thing rich in nitrogen of nontransparent shape be presented, stop
Stirring;
(5) it is filling:Will(4)The oily liquids of middle preparation is filling in container, further container is carried out being filled with nitrogen and makes appearance
Gas pressure intensity is more than 1.2 atmospheric pressure in device, pressurizing window, packaging, examines, produces.
15. hydrophily lipid composite is deployed into the side of emulsion with water fluid in the packaging compositions described in claim 8
Method, including:Hydrophily lipid composite is added in the container for accommodating water fluid, wherein water fluid and hydrophily fat
The weight ratio of based composition is more than 3:1, the cumulative volume of hydrophily lipid composite and water fluid is no more than container capacity
98%, the lid of container is tightened, bottle will be allocated in the frequency of shaking at least 1 time of being shaken in 1 second with hand or manipulator, container is shaken rolling
No more than 10 seconds, container shake rolling when, the distance of each displacement of container is not less than 10 centimetres, and makes mixed liquor to the surplus of container
Complementary space moves and forms emulsion;
The container of the water fluid, selected from vial with cover, plastic bottle with cover, aluminium with cover-modeling carton, gold with cover
Belong to container, and the volume of container is not more than 3 liters.
16. the method that hydrophily lipid composite according to claim 15 is deployed into emulsion with water fluid, described
The weight ratio of water fluid and hydrophily lipid composite is(10~300):1.
17. the method that hydrophily lipid composite according to claim 15 is deployed into emulsion with water fluid, described
Allotment bottle shake rolling when, make mixed liquor to allotment bottle remaining space move and impact allocate bottle lid.
18. a kind of hydrophily lipid composite of foam type, contain liquid aliphatic, liposoluble substance B, emulsifying agent and nitrogen, institute
State emulsifying agent and be selected from following one or more materials:Phosphatide, sucrose fatty ester, list, diglycerine fatty acid ester, polyglycereol fat
Acid esters, methyl glycol fatty acid ester, lactic acid fatty glyceride, polysorbas20, polysorbate40, polysorbate60, Tween 80, span 20, sapn
40th, the content of sorbester p18, sorbester p38, sorbester p17, wherein emulsifying agent in hydrophily lipid composite is using weight ratio meter as 0.1%
~7%;
The liquid aliphatic is selected from following one or more materials:Oleic acid, linoleic acid, leukotrienes, medium chain triglyceride, glycerine two
Ester, middle long chain fatty acids, wherein content of the liquid aliphatic in hydrophily lipid composite with weight ratio meter be more than 45%, it is described
Leukotrienes includes alpha-linolenic acid or gamma-Linolenic acid, and the middle long chain fatty acids include medium chain fatty acid or long chain fatty acids;
The liposoluble substance B is selected from following one or more materials:Lutein ester, lutein, Co-Q10, carrotene, shrimp
Blue or green element, lycopene, isoflavones, wherein contents of the liposoluble substance B in hydrophily lipid composite is with weight ratio meter
For 0.01%~30%;
Its preparation method, including:
(1) dispensing:Emulsifying agent, liquid aliphatic, other liposoluble substances are weighed by formula, is settled to required output, stirring is mixed
Splitting or integrating dissipates uniform;
(2) liquid prepared in (1) is placed in emulsion tank, nitrogen is continually fed into oily liquids or keeps emulsion tank
In pressure be more than 1.3 atmospheric pressure, and be stirred 3~25min of operation under conditions of speed of agitator is more than 300r/min, make
The grease thing of the foam type rich in nitrogen of nontransparent shape is presented in oily liquids, stops stirring;
(3) it is filling:Will(2)The oily liquids of middle preparation is filling in container, further container is carried out to be filled with nitrogen, and make appearance
Gas pressure intensity is more than 1.2 atmospheric pressure in device, pressurizing window, packaging, examines, produces.
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