Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
  • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
  • A61K8/9783—Angiosperms [Magnoliophyta]
  • A61K8/9789—Magnoliopsida [dicotyledons]
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
  • A61K8/0216—Solid or semisolid forms
  • A61K8/022—Powders; Compacted Powders
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
  • A61K8/04—Dispersions; Emulsions
  • A61K8/06—Emulsions
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
  • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
  • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
  • A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine

Definitions

• the present invention relates to a cosmetic composition for alleviating skin inflammation, and more particularly to a cosmetic composition for alleviating skin irritation and skin inflammation containing hydrangea fermented product.
• One of the most important functions of the skin is its protective function as a barrier. Skin exposed directly to the outside environment is the most important primary line of defense against loss of body fluids and protecting the body from harmful environments. It also acts as a barrier against toxic substances, microorganisms, physical stimuli or ultraviolet rays. However, when the skin barrier function is subjected to various stimuli outside and inside the skin, the skin barrier is damaged and the skin becomes hay or the skin is irritated. In addition, failure to effectively control the initial inflammatory reaction occurs at this time may be aggravated by severe dermatitis.
• IL-6 inter leukin-6
• IL-8 inter leukin-8
• IL- ⁇ inter leukin- ⁇
• IL-6 is a typical cytokine produced by activated monocytes, epithelial cells and vascular endothelial cells to mediate inflammatory reactions.
• IL-6 is secreted by T cells and macrophages to stimulate immune response and inflammatory reactions. It is a cytokine that regulates it.
• Activated macrophage also activates the inflammatory process by overproducing nitric oxide (NO) or prostaglandin (E2) (PGE2) as well as inflammation-inducing cytokines. Promoting and anti-inflammatory microdust particles have been reported to increase the expression of these inflammatory cytokines in human keratinocytes.
• NO nitric oxide
• PGE2 prostaglandin
• Korean Laid-Open Patent Publication No. 2007-0011939 proposes a cosmetic composition containing a camellia flower extract.
• Korean Patent Publication No. 2010-0086698 proposes a skin composition for calming and irritating the skin including mung bean fermentation-enzyme extract
• Korean Patent Publication No. 2013-0016930 discloses a sage, lemon balm, wood starch and onion extract. Atopic skin and skin irritation cosmetic composition comprising as an active ingredient was mentioned.
• 2015-0078948 proposes a cosmetic composition for improving skin inflammation or alleviating skin irritation, including mistletoe, pine 3 ⁇ 4 and rock brush combination extract as an active ingredient, Korean Patent Publication No. 2009-0091547 It proposes a cosmetic composition for anti-inflammatory and skin irritation relief containing a mixed extract of and casualties.
• none of the cosmetic compositions described above It does not describe the skin irritation and skin inflammation relieving effect of the same hydrangea fermented extract.
• the present inventors have studied to overcome the problems of the prior art, as a result of recognizing that the inflammatory cytokines increased by various stimuli, in particular fine dust stimulation is associated with skin irritation and dermatitis Screening of plant extracts that inhibit the expression of inflammatory cytokines was screened and screened. Among them, fermented hydrangea extracts suppressed the expression of inflammatory-induced cytokines IL-6, IL-8 and IL- ⁇ . By confirming that it is effective in alleviating skin irritation and inflammation, thereby completing the present invention.
• the main object of the present invention is to reduce the skin irritation and inflammation by inhibiting the expression of the inflammation-induced cytokines IL-6, IL-8 and IL- ⁇ that are increased by various stimuli, in particular fine dust stimulation It is to provide a cosmetic composition for alleviating skin inflammation containing a hydrangea fermentation having.
• Another object of the present invention is the hydrangea fermentation product of the present invention is applied as a base formulation of the functional cosmetic composition to impart skin irritation and skin inflammation alleviating effect to prevent and improve skin troubles, improve hunger, prevent dermatitis and improve To provide a cosmetic composition that can be.
• the present invention provides a cosmetic composition for skin irritation relief and skin inflammation alleviation containing hydrangea fermented product as an active ingredient.
• Hydrangea Ulydrangea macrophyUa is a deciduous shrub of the Rosaceae genus, which blooms in June-July and initially becomes light blue and then turns pale again. Depending on the soil, the color changes from neutral to white, acidic to blue, and alkaline to pink.
• the present inventors have confirmed that hydrangea fermentation can alleviate skin irritation and skin inflammation by inhibiting the expression of inflammation-induced cytokines, and completed the present invention.
• the above-mentioned fermented soybean product is obtained by fermenting a spoonful of sesame seed extract.
• “Fermentation using Ewha Valley” means cultivating a mixture of hwahwagok and water, specifically hwahwago 10%, hydrangea extract 13 ⁇ 4, the remaining weight part is mixed in a ratio of 89% water 25t ;, 4 Anaerobic daily production it means.
• the hwahwagok means the leaven made with rice, preferably characterized in that prepared by inoculating the koji culture and yeast liquid culture cultured rice cake.
• the Koji culture is sterilized with rice calibrated at 38-42% water at 121 ° C. for 30 minutes, inoculated with Rhesus bacteria (Aspergi l lus oryzae) and cultured and dried solid culture (Koj i).
• yeast liquid culture Sacharomyces cerevi si ae refers to the culture cultured yeast in potato dextrose liquid medium.
• the hydrangea extract may be extracted with any solvent conventionally used, preferably with water, lower alcohols having 1 to 4 carbon atoms, butylene glycol, propylene glycol, glycerin or a mixed solvent thereof Characterized in that.
• a conventional plant extraction method for example, hot water extraction, reflux angle extraction, ultrasonic extraction, supercritical extraction, etc. may be used. Specifically, hydrangea is crushed to make powder Then, it was immersed in the aforementioned extraction solvent and extracted at room temperature for 24 to 72 hours.
• the hydrangea fermentation is characterized in that it contains 0.001 to 30% by weight relative to the total weight of the cosmetic composition. If the hydrangea fermentation is less than 0.001 weight 3 ⁇ 4, there is a possibility that the skin inflammatory effect is weak, it is not preferable, and conversely, more than 30 weight 3 ⁇ 4> may be undesirable in terms of economics.
• the hydrangea fermentation is characterized in that to reduce the skin irritation and inflammation by inhibiting inflammatory cytokines.
• the hydrangea fermentation of the present invention showed an excellent inhibitory effect, in particular the skin inflammation inhibitory effect than the non-fermented hydrangea extract It was confirmed that it is better. From these results, it can be seen that the hydrangea fermentation product of the present invention can not only relieve skin inflammation by inhibiting inflammation-induced cytokines, but also relieve skin irritation such as fine dust.
• the cosmetic composition is one selected from the group consisting of flexible lotion, nutrition lotion, nutrition essence, nutrition oil, moisturizing oil, nutrition cream, powder, pack, foundation, makeup base, cleansing, shampoo, lotion ointment It is characterized by the above-mentioned formulation.
• Ingredients included in the cosmetic composition of the present invention as an active ingredient may include components commonly used in cosmetic compositions in addition to the fermentation product, for example, conventional auxiliary agents such as stabilizers, solubilizers, vitamins, pigments and flavorings. And carriers.
• the hydrangea fermentation product of the present invention is characterized by the expression of inflammatory induced cytokines ((IL-6, IL-8, IL- ⁇ ) overexpressed by various stimuli, in particular, fine dust. It can be effectively suppressed to alleviate skin irritation and skin inflammation.
• inflammatory induced cytokines (IL-6, IL-8, IL- ⁇ ) overexpressed by various stimuli, in particular, fine dust. It can be effectively suppressed to alleviate skin irritation and skin inflammation.
• Example 1 is a view showing the results for Experimental Example 1 showing the degree of IL-6 gene expression inhibition of inflammation-induced cytokines.
• Figure 2 is a view showing the results for Experiment 1 showing the degree of gene expression inhibition of inflammation-induced cytokines.
• Figure 3 is a diagram showing the results for Experiment 1 showing the degree of inhibition of IL-1 ⁇ gene expression in inflammation-induced cytokines.
• Figure 4 is a view showing a photograph of the result of measuring that the epidermal layer damaged by the fine dust is recovered when the hydrangea cabbage fermentation extract treatment.
• Hydrangea fermented product was prepared by using the hydrangea extract of the hydrangea extract obtained in Example 1.
• Ewhagok is characterized by the use of two kinds of spawns of koji culture and yeast liquid culture.
• Cozy culture is a solid culture (Koj i) cultured and dried by inoculation with Rhesus bacteria (Aspergi l lus oryzae) after sterilization of rice calibrated to 38-42% water at 121 ° C for 30 minutes.
• Yeast liquid culture (Saccharomyces cerevi siae) refers to the culture cultured yeast in potato dextrose liquid medium.
• the hwahwago of the present invention is made by the following method, first, 100 parts by weight of the washed rice 20 to 24 hours at 60 ° C., and then crushed. The powder that has passed through the sieve of about 40 mesh is recovered, watered to 40 to 45% of water, and then formed in a uniform shape. Round rice is reshaped into hole cakes and then steamed at 100 ° C for 1 hour. Two kinds of koji culture and yeast liquid culture incubated beforehand are inoculated and mixed to 13 ⁇ 4 of each weight part. Complete the Ewha Valley by incubating the unit for 4 days at 25 ° C.
• the amount of expression was measured by treating fine dust (PM10) on IL-1 ⁇ , IL-6, and IL-8, which are inflammation-induced cytokines. More specifically, the fine dust was treated for HaCaT cells, which are keratinocytes, and each raw material produced in Examples 1 and 2 was brought to a final concentration.
• PM10 fine dust
• HaCaT cells which are keratinocytes
• the lotion containing the fermented extract obtained in Example 2 was prepared by the usual method according to the composition components and composition ratios shown in Table 1 below.
• a moisture cream containing the fermented extract obtained in Example 2 was prepared according to a conventional method according to the composition and composition ratio as shown in Table 2 below. Table 2
• a moisturizing cream containing the fermented extract obtained in Example 2 was prepared by a conventional method according to the composition and composition ratio as shown in Table 3 below.
• the cosmetic composition containing the hydrangea fermentation product according to the present invention as an active ingredient inhibits the expression of inflammation-induced cytokines (IL-6, IL-8, IL-1 ⁇ ) and stimulates the skin.
• inflammation-induced cytokines IL-6, IL-8, IL-1 ⁇
• Patent Document 0001 KR 10-2007-0011939 A (Patent Document 0002) KR 10-2010-0086698 A (Patent Document 0003) KR 10-2013-0016930 A (Patent Document 0004) KR 10-2015-0078948 A (Patent Document 0005) KR 10-2009-0091547 A

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• 2016
  • 2016-06-30 KR KR1020160082366A patent/KR101867308B1/ko active IP Right Grant
• 2017
  • 2017-06-30 CN CN201780040265.6A patent/CN109414399B/zh active Active
  • 2017-06-30 WO PCT/KR2017/006952 patent/WO2018004293A2/ko active Application Filing

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