WO2017185475A1 - 一种氧化锆牙种植体表面处理方法 - Google Patents

一种氧化锆牙种植体表面处理方法 Download PDF

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WO2017185475A1
WO2017185475A1 PCT/CN2016/084137 CN2016084137W WO2017185475A1 WO 2017185475 A1 WO2017185475 A1 WO 2017185475A1 CN 2016084137 W CN2016084137 W CN 2016084137W WO 2017185475 A1 WO2017185475 A1 WO 2017185475A1
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dental implant
zirconia
implant
treatment
concentration
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PCT/CN2016/084137
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English (en)
French (fr)
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王昌健
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成都贝施美医疗设备有限公司
成都贝施美生物科技有限公司
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Publication of WO2017185475A1 publication Critical patent/WO2017185475A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/01—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics
    • C04B35/48—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on zirconium or hafnium oxides, zirconates, zircon or hafnates
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B41/00—After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone
    • C04B41/009—After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone characterised by the material treated
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B41/00—After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone
    • C04B41/45—Coating or impregnating, e.g. injection in masonry, partial coating of green or fired ceramics, organic coating compositions for adhering together two concrete elements
    • C04B41/50—Coating or impregnating, e.g. injection in masonry, partial coating of green or fired ceramics, organic coating compositions for adhering together two concrete elements with inorganic materials
    • C04B41/5025—Coating or impregnating, e.g. injection in masonry, partial coating of green or fired ceramics, organic coating compositions for adhering together two concrete elements with inorganic materials with ceramic materials
    • C04B41/5042—Zirconium oxides or zirconates; Hafnium oxides or hafnates
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B41/00—After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone
    • C04B41/80—After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone of only ceramics
    • C04B41/81—Coating or impregnation
    • C04B41/85—Coating or impregnation with inorganic materials
    • C04B41/87—Ceramics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/12—Materials or treatment for tissue regeneration for dental implants or prostheses

Definitions

  • the present invention belongs to the technical field of oral prosthetics, and in particular relates to a surface treatment method for zirconia dental implants.
  • titanium implants are mainly used in clinical practice. In order to improve titanium implant-bone binding ability and shorten healing healing, most of them are treated on pure titanium planting surface.
  • TiUnite titanium easily, porous titanium oxide structure
  • the implants produced by Swiss company Zhuoman are carried out on the surface.
  • SLA large particle etch blasting
  • SLActive active hydrophilic
  • the surface roughness can reach 1.5-1.8 ⁇ , and the bone contact area is increased by 192% compared with the mechanical area.
  • individual patients with titanium implants are allergic to Ti, undergo CT scans, and MRI tests, which have an impact on the signal and limit their widespread use.
  • zirconia ceramic implants have good biocompatibility, no irritation to gums, no allergic reaction, high strength and other excellent properties, and gradually replace titanium implants to become an emerging implant. Application prospects.
  • the zirconia ceramic and the acid are less likely to react, and therefore, it is difficult to form an acid-etched porous structure on the surface of the implant.
  • the secondary sintering will form a fault on the surface of the implant, which affects the success rate of planting.
  • no systematic research has been done on the surface treatment method of zirconia ceramic implants.
  • the object of the present invention is to overcome the shortcomings of the prior art and provide a surface treatment method for a zirconia dental implant, which is simple in operation, convenient in processing, low in cost, and suitable for industrialized mass production.
  • a method for treating a surface of a zirconia dental implant It includes the following steps:
  • Acid etching the dental implant after the borax treatment is completely immersed in an acidic solution for acid etching to obtain an acid-etched dental implant; wherein the acidic solution is HF and ⁇ 3
  • the concentration of HF is 1.5 ⁇ 2.3mol/L, and the concentration of HNO 3 is 5 ⁇ 5.8mol/L;
  • the ball-milled zirconia powder is configured to be suspended in water, and the dental implant after the step S3 is soaked in the suspension for 4 ⁇ 8 s;
  • S5. Sintering The soaked dental implant is sintered at a temperature of 1500 to 1600 ° C for 1 to 1.5 hours.
  • the anhydrous ethanol washing time is 12 to 18 minutes, and the deionized water cleaning time is 5 to 10 minutes.
  • the borax treatment is performed, the nozzle is 0.5 to 1.5 cm away from the dental implant, and the nozzle is uniformly sprayed perpendicular to the dental implant for 20 to 40 s.
  • the concentration of the suspension in step S4 is 0.005 to 0.01%.
  • the present invention has the following advantages:
  • the present invention is impregnated with a ball-milled zirconia suspension on the surface of the zirconia ceramic implant, and the porous pore diameter of the zirconia ceramic implant surface is controlled by the difference in particle size of the zirconia powder after ball milling.
  • the same blasting and acid etching treatment before immersion increased the surface roughness of the denture to a certain extent. Due to the later sintering, the surface roughness of the denture is significantly increased, so that the implant material and the host bone can be improved.
  • the interface effect increases the binding ability between the implant and the bone, thereby improving the clinical success rate of the dental implant;
  • the method of the invention is simple in operation, convenient in processing, low in cost, and suitable for industrial large-scale production.
  • Embodiment 1 A zirconia dental implant surface treatment method, comprising the following steps:
  • the dry day of anhydrous ethanol is 12min, and the time of deionized water is 5min;
  • Sandblasting treatment the washed dental implant is subjected to borax treatment with alumina particles having a diameter of 125 ⁇ m under a pressure of 0.5 MPa; the borax is treated with a nozzle, the nozzle is 0.5 cm from the dental implant, and the nozzle Sprayed evenly on the dental implant for 20s;
  • the concentration of HF is 1.5 mol / L, the concentration of HNO 3 is 5 mol / L;
  • the ball-milled zirconia powder is configured to be suspended in water, and the concentration of the suspension is 0.005%.
  • the dental implant after the acid etching in step S3 is immersed in the suspension for 4 s;
  • Example 2 A zirconia dental implant surface treatment method, which comprises the following steps:
  • the time of washing with absolute ethanol is 18min, and the time between deionized water cleaning is lOmin;
  • Sandblasting treatment the washed dental implant is subjected to borax treatment with alumina particles having a diameter of 140 ⁇ m under a pressure of 0.6 MPa; the borax is treated with a nozzle, the nozzle is 1.5 cm from the dental implant, and the nozzle Sprayed evenly on the dental implant for 40s;
  • the concentration of HF is 2.3 mol / L, the concentration of HNO 3 is 5.8 mol / L;
  • Example 3 A method for treating a surface of a zirconia dental implant, which comprises the following steps:
  • the concentration of HF is 1.7 mol / L, the concentration of HNO 3 is 5.3 mol / L;
  • step S4 Soaking: the ball-milled zirconia powder is arranged in a suspension with water, the concentration of the suspension is 0.007%, and the dental implant after the acid etching in step S3 is soaked in the suspension for 5 s;
  • Embodiment 4 A zirconia dental implant surface treatment method, which comprises the following steps:
  • the time of washing with absolute ethanol is 16min, and the time between deionized water is 9min;
  • step S4 Soaking: the ball-milled zirconia powder is arranged into a suspension with water, the concentration of the suspension is 0.009%, and the dental implant after the acid etching in step S3 is soaked in the suspension for 7 s;

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Ceramic Engineering (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Structural Engineering (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Materials Engineering (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Composite Materials (AREA)
  • Manufacturing & Machinery (AREA)
  • Dental Preparations (AREA)
  • Dental Prosthetics (AREA)

Abstract

一种氧化锆牙种植体表面处理方法，它包括清洗（S1）、喷砂处理（S2）、酸蚀（S3）、浸泡（S4）和烧结（S5）。在氧化锆陶瓷种植体表面浸有球磨后的氧化锆悬浮液，利用球磨后氧化锆粉体的粒径不同来控制氧化锆陶瓷种植体表面的多孔孔径，同时在浸泡前进行了喷砂和酸蚀处理，一定程度上增加了义齿表面粗糙度，由于后期的烧结，使义齿表面的粗糙度显著增加，因此，可以改善植入材料与宿主骨之前的界面效应，增加了种植体与骨之间的结合能力，从而提高了牙种植体的临床成功率；本方法操作简单、处理方便、成本低、适用于工业化大规模生产。

Description

说明书 发明名称：一种氧化锆牙种植体表面处理方法 技术领域
[0001] 本发明属于口腔修复技术领域， 具体涉及一种氧化锆牙种植体表面处理方法。
背景技术
[0002] 随着生活水平和审美要求的不断提高， 种植义齿修复已成为口腔修复的重要组 成部分。 目前， 临床上主要应用的是钛种植体， 为了提高钛种植体 -骨结合能力 以及缩短愈合吋间， 大多在纯钛种植表面进行处理。 例如瑞典诺贝尔公司生产 的种植体表面进行了 TiUnite (钛易耐， 多孔性的氧化钛结构） 表面处理， 可以 有效的促进与骨的结合； 瑞士士卓曼公司生产的种植体在其表面进行了 SLA (大 颗粒酸蚀喷砂） 处理， 以及在 SLA基础上进一步升级了 SLActive (活性亲水） 表 面处理技术； 韩国登腾公司生产的种植体表面进行了 RBM (可吸收性喷砂介质 ) 处理， 其表面粗糙度可以达到 1.5-1.8μηι间， 与骨接触面积比机械面积增加 192 %。 但是， 钛种植体个别患者对 Ti过敏， 进行 CT扫描、 核磁共振检査吋， 对信 号产生影响， 限制了其广泛应用。
[0003] 近年来， 研究发现氧化锆陶瓷种植体生物相容性好， 对牙龈无刺激， 无过敏反 应， 具有高强度等优异性质， 逐渐代替钛种植体而成为一种新兴种植体， 有着 广泛的应用前景。 但氧化锆陶瓷和酸不易发生反应， 因此， 很难在种植体表面 形成酸蚀后的多孔结构。 同吋， 对氧化锆陶瓷种植体表面等离子喷射羟基磷灰 石后， 由于进行二次烧结， 会在种植体表面形成断层， 影响了种植的成功率。 目前， 对于氧化锆陶瓷种植体的表面处理方法还没有形成系统的研究。
技术问题
[0004] 本发明的目的在于克服现有技术的缺点， 提供种氧化锆牙种植体表面处理方法 ， 该方法操作简单、 处理方便、 成本低、 适用于工业化大规模生产。
问题的解决方案
技术解决方案
[0005] 本发明的目的通过以下技术方案来实现： 一种氧化锆牙种植体表面处理方法， 它包括以下步骤：
[0006] SI.清洗： 将氧化锆牙种植体经过无水乙醇和去离子水超声清洗， 并自然干燥
[0007] S2.喷砂处理： 将清洗后的牙种植体在 0.5〜0.6MPa的气压下， 以直径为 125
〜140μηι的氧化铝颗粒进行硼砂处理；
[0008] S3.酸蚀： 浆硼砂处理处理后的牙种植体完全浸没于酸性溶液进行酸蚀， 得到 酸蚀的牙种植体； 其中， 所述酸性溶液为 HF和 ΗΝΟ 3
的混合溶液， HF的浓度为 1.5〜2.3mol/L， HNO 3的浓度为 5〜5.8mol/L;
[0009] S4.浸泡： 将球磨后的氧化锆粉体用水配置成悬浮液， 将步骤 S3酸蚀后的牙种 植体浸泡在悬浮液中浸泡 4〜8s；
[0010] S5.烧结： 将浸泡后的牙种植体在 1500〜1600°C温度下烧结 l〜1.5h。
[0011] 进一步地， 步骤 S1中所述无水乙醇清洗的吋间为 12〜18min， 去离子水清洗的 吋间为 5〜10min。
[0012] 进一步地， 步骤 S2所述硼砂处理吋， 喷嘴距离牙种植体 0.5〜1.5cm， 喷嘴垂 直于牙种植体均匀喷射 20〜40s。
[0013] 进一步地， 步骤 S4中所述悬浮液的浓度 0.005〜0.01%。
发明的有益效果
有益效果
[0014] 本发明具有以下优点： 本发明在氧化锆陶瓷种植体表面浸有球磨后的氧化锆悬 浮液， 利用球磨后氧化锆粉体的粒径不同来控制氧化锆陶瓷种植体表面的多孔 孔径， 同吋在浸泡前进行了喷砂和酸蚀处理， 一定程度上增加了义齿表面粗糙 度， 由于后期的烧结， 使义齿表面的粗糙度显著增加， 因此， 可以改善植入材 料与宿主骨之前的界面效应， 增加了种植体与骨之间的结合能力， 从而提高了 牙种植体的临床成功率； 本发明方法操作简单、 处理方便、 成本低、 适用于工 业化大规模生产。
本发明的实施方式
[0015] 下面结合实施例对本发明做进一步的描述， 本发明的保护范围不局限于以下所 述。
[0016] 实施例 1 : 一种氧化锆牙种植体表面处理方法， 它包括以下步骤：
[0017] S1.清洗： 将氧化锆牙种植体经过无水乙醇和去离子水超声清洗， 并自然干燥
； 无水乙醇清洗的吋间为 12min， 去离子水清洗的吋间为 5min;
[0018] S2.喷砂处理： 将清洗后的牙种植体在 0.5MPa的气压下， 以直径为 125μηι的 氧化铝颗粒进行硼砂处理； 所述硼砂处理吋， 喷嘴距离牙种植体 0.5cm， 喷嘴垂 直于牙种植体均匀喷射 20s ;
[0019] S3.酸蚀： 浆硼砂处理处理后的牙种植体完全浸没于酸性溶液进行酸蚀， 得到 酸蚀的牙种植体； 其中， 所述酸性溶液为 HF和 HNO 3
的混合溶液， HF的浓度为 1.5mol/L， HNO 3的浓度为 5mol/L;
[0020] S4.浸泡： 将球磨后的氧化锆粉体用水配置成悬浮液， 悬浮液的浓度 0.005%， 将步骤 S3酸蚀后的牙种植体浸泡在悬浮液中浸泡 4s ;
[0021] S5.烧结： 将浸泡后的牙种植体在 1500°C温度下烧结 lh。
[0022] 实施例 2: —种氧化锆牙种植体表面处理方法， 它包括以下步骤：
[0023] S1.清洗： 将氧化锆牙种植体经过无水乙醇和去离子水超声清洗， 并自然干燥
； 无水乙醇清洗的吋间为 18min， 去离子水清洗的吋间为 lOmin;
[0024] S2.喷砂处理： 将清洗后的牙种植体在 0.6MPa的气压下， 以直径为 140μηι的 氧化铝颗粒进行硼砂处理； 所述硼砂处理吋， 喷嘴距离牙种植体 1.5cm， 喷嘴垂 直于牙种植体均匀喷射 40s ;
[0025] S3.酸蚀： 浆硼砂处理处理后的牙种植体完全浸没于酸性溶液进行酸蚀， 得到 酸蚀的牙种植体； 其中， 所述酸性溶液为 HF和 HNO 3
的混合溶液， HF的浓度为 2.3mol/L， HNO 3的浓度为 5.8mol/L;
[0026] S4.浸泡： 将球磨后的氧化锆粉体用水配置成悬浮液， 悬浮液的浓度 0.01%， 将 步骤 S3酸蚀后的牙种植体浸泡在悬浮液中浸泡 8s ;
[0027] S5.烧结： 将浸泡后的牙种植体在 1600°C温度下烧结 1.5h。
[0028] 实施例 3: —种氧化锆牙种植体表面处理方法， 它包括以下步骤：
[0029] S1.清洗： 将氧化锆牙种植体经过无水乙醇和去离子水超声清洗， 并自然干燥
； 无水乙醇清洗的吋间为 14min， 去离子水清洗的吋间为 7min; [0030] S2.喷砂处理： 将清洗后的牙种植体在 0.54MPa的气压下， 以直径为 130μηι的 氧化铝颗粒进行硼砂处理； 所述硼砂处理吋， 喷嘴距离牙种植体 0.8cm， 喷嘴垂 直于牙种植体均匀喷射 28s ;
[0031] S3.酸蚀： 浆硼砂处理处理后的牙种植体完全浸没于酸性溶液进行酸蚀， 得到 酸蚀的牙种植体； 其中， 所述酸性溶液为 HF和 HNO 3
的混合溶液， HF的浓度为 1.7mol/L， HNO 3的浓度为 5.3mol/L;
[0032] S4.浸泡： 将球磨后的氧化锆粉体用水配置成悬浮液， 悬浮液的浓度 0.007%， 将步骤 S3酸蚀后的牙种植体浸泡在悬浮液中浸泡 5s ;
[0033] S5.烧结： 将浸泡后的牙种植体在 1530°C温度下烧结 1.2h。
[0034] 实施例 4: 一种氧化锆牙种植体表面处理方法， 它包括以下步骤：
[0035] S1.清洗： 将氧化锆牙种植体经过无水乙醇和去离子水超声清洗， 并自然干燥
； 无水乙醇清洗的吋间为 16min， 去离子水清洗的吋间为 9min;
[0036] S2.喷砂处理： 将清洗后的牙种植体在 0.58MPa的气压下， 以直径为 135μηι的 氧化铝颗粒进行硼砂处理； 所述硼砂处理吋， 喷嘴距离牙种植体 1.3cm， 喷嘴垂 直于牙种植体均匀喷射 35s ;
[0037] S3.酸蚀： 浆硼砂处理处理后的牙种植体完全浸没于酸性溶液进行酸蚀， 得到 酸蚀的牙种植体； 其中， 所述酸性溶液为 HF和 HNO 3
的混合溶液， HF的浓度为 2ol/L， ΗΝΟ ^ 浓度为 5.6mol/L;
[0038] S4.浸泡： 将球磨后的氧化锆粉体用水配置成悬浮液， 悬浮液的浓度 0.009%， 将步骤 S3酸蚀后的牙种植体浸泡在悬浮液中浸泡 7s ;
[0039] S5.烧结： 将浸泡后的牙种植体在 1585°C温度下烧结 1.4h。

Claims

权利要求书
[权利要求 1] 一种氧化锆牙种植体表面处理方法， 其特征在于， 它包括以下步骤：
51.清洗： 将氧化锆牙种植体经过无水乙醇和去离子水超声清洗， 并自然干燥；
52.喷砂处理： 将清洗后的牙种植体在 0.5〜0.6MPa的气压下， 以直 径为 125〜140μηι的氧化铝颗粒进行硼砂处理；
53.酸蚀： 浆硼砂处理处理后的牙种植体完全浸没于酸性溶液进行酸 蚀， 得到酸蚀的牙种植体； 其中， 所述酸性溶液为 HF和 ΗΝΟ 3的混合 溶液， HF的浓度为 1.5〜2.3mol/L， HNO 3的浓度为 5〜5.8mol/L;
54.浸泡： 将球磨后的氧化锆粉体用水配置成悬浮液， 将步骤 S3酸蚀 后的牙种植体浸泡在悬浮液中浸泡 4〜8s；
55.烧结： 将浸泡后的牙种植体在 1500〜1600°C温度下烧结 l〜1.5h。
[权利要求 2] 如权利要求 1所述的一种氧化锆牙种植体表面处理方法， 其特征在于
， 步骤 S1中所述无水乙醇清洗的吋间为 12〜18min， 去离子水清洗的 吋间为 5〜10min。
[权利要求 3] 如权利要求 1所述的一种氧化锆牙种植体表面处理方法， 其特征在于
， 步骤 S2所述硼砂处理吋， 喷嘴距离牙种植体 0.5〜1.5cm， 喷嘴垂直 于牙种植体均匀喷射 20〜40s。
[权利要求 4] 如权利要求 1所述的一种氧化锆牙种植体表面处理方法， 其特征在于
， 步骤 S4中所述悬浮液的浓度 0.005〜0.01%。
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Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107266066A (zh) * 2017-05-25 2017-10-20 绍兴华晶科技有限公司 一种氧化锆种植体的表面处理方法
CN107266065A (zh) * 2017-05-25 2017-10-20 绍兴华晶科技有限公司 氧化锆种植体的表面处理方法
CN108283731B (zh) * 2017-12-22 2021-07-09 香港大学深圳医院 一种氧化锆表面的纳米介孔磷酸钙颗粒涂层、其制备方法及用途
EP4371548A2 (en) * 2018-03-30 2024-05-22 Shofu Inc. Opaque imparting liquid for zirconia
CN109125801A (zh) * 2018-07-05 2019-01-04 广州壹凌医疗器械科技有限公司 一种氧化锆表面处理的方法
CN109674546A (zh) * 2018-12-19 2019-04-26 洋紫荆牙科器材(北京)有限公司 一种义齿种植体表面处理工艺
CN109608233A (zh) 2019-01-30 2019-04-12 成都贝施美医疗科技股份有限公司 一种改善牙科用二氧化锆陶瓷通透性的技术
CN109987969B (zh) * 2019-04-29 2021-07-06 成都贝施美生物科技有限公司 一种快速浸泡氧化锆义齿染色液
CN111646822B (zh) * 2020-03-27 2021-04-06 温州医科大学附属口腔医院 一种氧化锆陶瓷表面原位生长蜂窝状纳米结构的制备方法及制备的改性氧化锆陶瓷
CN111807835A (zh) * 2020-07-25 2020-10-23 巩义正宇新材料有限公司 一种高稳定氧化锆及其生产工艺
CN112274692B (zh) * 2020-09-29 2023-06-09 嘉兴市京吟生物科技有限公司 氧化锆种植体生物涂层制备方法及氧化锆种植体
CN116571422A (zh) * 2023-04-27 2023-08-11 无锡斯贝尔磁性材料有限公司 一种eq36产品涂层方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005027771A1 (en) * 2003-09-24 2005-03-31 Nobel Biocare Ab (Publ) Method and arrangement for a dental installation
CN101332130A (zh) * 2007-04-19 2008-12-31 斯特劳曼控股公司 提供牙种植体表面形貌的方法
CN101707927A (zh) * 2007-07-06 2010-05-12 维塔假牙制造厂H·劳特有限责任两合公司 陶瓷体及其制备方法
CN102499899A (zh) * 2011-10-25 2012-06-20 辽宁爱尔创生物材料有限公司 一种氧化锆陶瓷种植体的表面处理方法
CN105125413A (zh) * 2015-07-17 2015-12-09 南宁市美皓医疗器械有限公司 微创磨牙玻璃陶瓷贴面的制作方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1237945C (zh) * 2000-10-09 2006-01-25 刘宝林 改良的牙种植体表面的喷砂处理方法
CN102232876A (zh) * 2010-05-06 2011-11-09 江苏创英医疗器械有限公司 牙种植体表面处理工艺
CN102552044B (zh) * 2012-01-19 2014-01-08 浙江大学 一种多尺度复杂结构的牙种植体表面的制备方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005027771A1 (en) * 2003-09-24 2005-03-31 Nobel Biocare Ab (Publ) Method and arrangement for a dental installation
CN101332130A (zh) * 2007-04-19 2008-12-31 斯特劳曼控股公司 提供牙种植体表面形貌的方法
CN101707927A (zh) * 2007-07-06 2010-05-12 维塔假牙制造厂H·劳特有限责任两合公司 陶瓷体及其制备方法
CN102499899A (zh) * 2011-10-25 2012-06-20 辽宁爱尔创生物材料有限公司 一种氧化锆陶瓷种植体的表面处理方法
CN105125413A (zh) * 2015-07-17 2015-12-09 南宁市美皓医疗器械有限公司 微创磨牙玻璃陶瓷贴面的制作方法

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