WO2017164429A1 - Bille d'émulsion et son procédé de fabrication - Google Patents

Bille d'émulsion et son procédé de fabrication Download PDF

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Publication number
WO2017164429A1
WO2017164429A1 PCT/KR2016/002865 KR2016002865W WO2017164429A1 WO 2017164429 A1 WO2017164429 A1 WO 2017164429A1 KR 2016002865 W KR2016002865 W KR 2016002865W WO 2017164429 A1 WO2017164429 A1 WO 2017164429A1
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Prior art keywords
emulsion
beads
acid
alcohol
gum
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PCT/KR2016/002865
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English (en)
Korean (ko)
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신찬재
고태성
조현오
정성윤
홍여주
손태훈
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(주)바이오제닉스
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Priority to JP2017563218A priority Critical patent/JP2019512457A/ja
Publication of WO2017164429A1 publication Critical patent/WO2017164429A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the present invention relates to emulsion beads and a method for preparing the same, and more particularly, to a core-shell type emulsion beads and a method for preparing the same, including a liquid emulsion containing an active ingredient.
  • Korean Laid-Open Patent Publication No. 2009-0069741 discloses a method of simply cooling a solution containing pigment, carrageenan, agar and polyhydric alcohol to make a gel and extruding it through a micronozzle to obtain semi-transparent polymer gel beads.
  • Korean Laid-Open Patent No. 2009-0069741 discloses a method of simply cooling a solution containing pigment, carrageenan, agar and polyhydric alcohol to make a gel and extruding it through a micronozzle to obtain semi-transparent polymer gel beads.
  • 195-0012596 prepares an aqueous phase containing ethanol and water, and an oil phase containing digested polyisobutene, pearl powder and jojoba oil, respectively, and injecting the oil phase completely into the aqueous phase.
  • a fragrance lasting cosmetic containing dispersed pearlescent fluid beads.
  • the polymer gel beads or pearlescent fluid beads have little cosmetic role, but merely serve to modify the appearance of the cosmetics containing the same.
  • the present applicant has completed the present invention to provide an emulsion bead and a method of manufacturing the same that can maximize the stability of the active ingredient as well as minimize the skin irritation that can occur from the active ingredient.
  • An object of the present invention is to improve the stability of the active ingredient, to maximize the skin cosmetic effect, to provide an emulsion bead and a manufacturing method thereof that can satisfy the user's aesthetics.
  • a liquid emulsion containing an active ingredient is added to a freeze coolant maintained at a temperature of 10 ° C. or less to prepare solid beads, and to form a film using a cationic polymer material. It provides a method for producing an emulsion bead comprising the step.
  • the active ingredient according to an embodiment of the present invention is not limited so long as it shows an effective activity such as whitening and / or wrinkle improvement, UV blocking, skin moisturizing and / or soothing skin, but a non-limiting example thereof is medicinal tree Extract, Arbutin, Ethyl Ascorbyl Ether, Soluble Licorice Extract, Ascorbyl Glucoside, Magnesium Ascorbyl Phosphate, Niacinamide, Alpha-bisabolol, Ascorbyl Triisopalmitate, Retinol, Retinyl Palmitate, Adenosine, Poly Or at least one selected from toxylated retinamide, beta carotene, lutein, green tea polyphenols, catechins (EGCG), ubiquinol / quinone, and derivatives thereof.
  • the formulations stabilized in the above-described active ingredient also belong to the scope of the present invention.
  • Liquid emulsion according to an embodiment of the present invention is not limited, but is preferably water-in-oil type (W / O), oil-in-water type (O / W), water-in-oil type (W / O / W) or water-in-oil type (O / W / O) and the like, and may further include auxiliaries used in the art in addition to the above-mentioned active ingredient.
  • examples of the auxiliary agent include fatty substances, organic solvents, solubilizers, thickeners, gelling agents, softeners, antioxidants, suspending agents, stabilizers, blowing agents, surfactants, water, fillers, metal ion sequestrants, preservatives, ultraviolet rays Blocking agents, wetting agents, antioxidants, pH adjusting agents, oils, dyes, pigments and flavorings may be one or more selected, and may be appropriately selected and used according to the desired formulation and / or efficacy.
  • Method for producing an emulsion bead comprises the steps of forming a primary bead of a solid phase by a freeze cooling method using a freeze refrigerant; And forming a coating layer using a cationic polymer material using the primary beads as a core layer (core material).
  • the cationic polymer material is not limited as long as it is a material capable of forming a film, but preferred examples thereof include whey protein, collagen, gelatin, chitosan, cationic guar gum ( It is preferable to select from amine-containing polymer materials such as cationic gua gum, polylysine, polyvinylamine, and chitin.
  • the present invention is a solid phase bead comprising a liquid emulsion containing the active ingredient; And a shell layer containing a cationic polymer material using the beads as a core layer.
  • the core-shell type emulsion beads according to one embodiment of the present invention comprise at least one selected from lipid materials and gel-forming materials in a continuous phase.
  • the lipid material and the gel-forming material are coated with a feeling of use without foreign substances, and is not limited as long as it is a solid material at room temperature capable of forming a solid bead by a freezing refrigerant, but isostaryl alcohol, stearyl alcohol, cetyl Alcohol, cetostearyl alcohol, higher alcohols selected from behenyl alcohol, batyl alcohol, glyceryl monostearate, hexadecyl alcohol, and the like; Fatty acids selected from isostearic acid, oleic acid, lauric acid, stearic acid, palmitic acid, behenic acid and mystic acid; Petroleum waxes such as paraffin wax, polyethylene, wax, braze, beeswax and microcrystalline wax; Mineral waxes such as ozokerite and ceresin; Natural waxe
  • examples of the gel-forming substance include agar, carrageenan, sodium alginate, locust gum, guar gum, tara gum, gum arabic, xanthan gum, hyaluronic acid, pectin, konjac, karaya gum, tragacanth gum, lach gum, dex Tran, starch, cellulose, gelatin, and derivatives thereof, but is not limited thereto, and at least one selected from anionic lipid materials and gel-forming materials capable of ionically bonding with cationic polymer materials included in the shell layer. It is characterized by including.
  • the emulsion beads according to the present invention can stably minimize discoloration and / or lowering of titer even in the long term even under the influence of the external environment, thereby significantly increasing the stability of the cosmetic composition.
  • it is excellent in adhesion to the skin to give a soft and refreshing feeling, and can provide a differentiated appearance to increase the likelihood of the product.
  • the emulsion beads according to the invention can be stably held in shape without prolonged swelling and / or breakage, so that the quality of the filled product can be maintained for a long time.
  • 1 is a structure of the emulsion beads of the core-shell structure according to the present invention.
  • solid beads of the present invention may have the same meaning as “solid primary beads”, “core layer” and “core material”, and the term “film” is the same as “film layer” and “shell layer”. It can mean.
  • the present invention can significantly improve the stability of the active ingredient having a beneficial effect on the skin, by maximizing the skin cosmetic effect by continuously supplying it to the skin.
  • the emulsion beads according to the present invention is characterized in that the surface is cationic, it is designed to be applied with improved adhesion to the anionic skin due to this feature.
  • the emulsion beads according to an embodiment of the present invention can be visually identified to allow the user to satisfy curiosity and / or aesthetics, and to maximize the skin cosmetic effect by continuously supplying an active substance to the skin. .
  • Emulsion beads according to an embodiment of the present invention are solid phase beads including a liquid emulsion containing the active ingredient; And a shell layer containing a cationic polymer material using the beads as a core layer.
  • the emulsion beads are prepared in the form of a solid emulsion of a liquid bead, thereby primarily preventing oxidation by external influence factors such as heat, light, air, moisture, and metal ions, and further preventing oxidation by the shell layer. It will play a role.
  • the shell layer is characterized in that it is provided with at least one or more layers, in order to improve the stability of the active ingredient may of course have two or more layers.
  • the thickness of the shell layer is not limited, but may be formed to a thickness of 10 ⁇ m to 1,000 ⁇ m from the surface of the core layer, preferably 10 ⁇ m to 500 ⁇ m thickness, more preferably 10 ⁇ m to 300 ⁇ m thickness range It is good in terms of improving the stability of the effective material and providing a feeling of use without foreign substances.
  • Emulsion beads according to an embodiment of the present invention may have a shell layer in the core layer by physical bonding according to the hydrogel mechanism.
  • the core layer includes a material having an anionic property capable of ionically bonding with a cationic polymer material included in the shell layer.
  • the anionic material may be at least one selected from lipid material and gel-forming material.
  • the cationic polymer material according to an embodiment of the present invention is not limited as long as it is a material capable of forming a film, but a preferred example is whey protein, collagen, gelatin, chitosan, and chitosan.
  • Cationic guar gum (Cationic gua gum), polylysine (Polylysine), polyvinylamine (Polyvinylamine), chitin (chitin) and the like
  • Cationic guar gum (Cationic gua gum)
  • Polylysine Polylysine
  • polyvinylamine Polyvinylamine
  • chitin (chitin) and the like may be selected from one or more amine-containing polymers, more preferably whey protein (whey) protein, collagen (collagen), gelatin (Gelatin), chitosan (Chitosan), chitin (chitin) and the like is preferably at least one.
  • the active ingredient according to an embodiment of the present invention is not limited as long as it shows an effective activity such as whitening and / or wrinkle improvement, UV blocking, skin moisturizing and / or soothing, but is not limited thereto.
  • the formulations stabilized in the above-described active ingredient also fall within the scope of the present invention.
  • the emulsion bead according to an embodiment of the present invention is not limited, but it can be crushed well by hand with a small force to give a soft feeling and improved adhesion, and even when used in a pumping container, the emulsion bead is broken while being pumped and used. A feeling of use and adhesiveness can also be provided.
  • Method for producing an emulsion bead comprises the steps of forming a primary bead of a solid phase by a freeze cooling method using a freeze refrigerant; And forming a film from a cationic polymer material using the primary bead as a core layer (core material).
  • the primary bead according to an embodiment of the present invention can be prepared by dropping a liquid emulsion containing the active ingredient in a freeze refrigerant maintained at a temperature of 10 °C or less.
  • the liquid emulsion is not limited, but preferably water-in-oil type (W / O), oil-in-water type (O / W), water-in-oil type (W / O / W) or oil-in-water type (O / W / O)
  • the liquid emulsion may be prepared by mixing one or more two or more liquid emulsions.
  • the active ingredient is not limited as long as it shows an effective activity such as whitening and / or wrinkle improvement, UV blocking, skin moisturizing and / or soothing skin.
  • the liquid emulsion according to an embodiment of the present invention may further include an adjuvant used in the art in addition to the above-described active ingredient.
  • the auxiliary agent include fatty substances, organic solvents, solubilizers, thickeners, gelling agents, softeners, antioxidants, suspending agents, stabilizers, blowing agents, surfactants, water, fillers, metal ion sequestrants, preservatives, ultraviolet rays Blocking agents, wetting agents, antioxidants, pH adjusting agents, oils, dyes, pigments and flavorings may be one or more selected, and may be appropriately selected and used according to the desired formulation and / or efficacy.
  • Non-limiting examples of fatty substances in the aforementioned adjuvants include cholesterol; Phytosterols; Sphingosine; Phytosphingosine; Cerebroside; Ceramide I, Ceramide II, Ceramide III, Ceramide IIIB, Ceramide IV, Ceramide V, Ceramide VI, Alkanolamide are myristyl oxostearamide monoethanolamine, Myristyl arachidamide monoethanolamine, Palmityl oxostearamide monoethanol Ceramides such as amine and palmityl arachidamide monoethanolamine; Saturated or unsaturated fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid or linoleic acid; Lanolin alcohol, lauryl alcohol, myristyl alcohol, batyl alcohol, behenyl alcohol, benzyl alcohol, cetearyl alcohol, cetyl alcohol, stearyl alcohol, arachidyl alcohol, oleyl alcohol, isocety
  • the organic solvent may be ethanol, propanol, glycerol, 2-butoxyethanol, propylene glycol, propylene glycol, benzyl alcohol, phenoxyethanol, and the like, and non-limiting examples of the antioxidant adenosine, arbutin, vitamin C, vitamin B3, vitamin B5, vitamin H, kojic acid (Kojic acid), acetylglucosamine and the like, the pH adjuster by mixing the acidic and alkaline substances to maintain the pH value of the cosmetic composition is 5.0 to 7.0 It is preferred to be used.
  • triacidolamine, sodium chloride such as lactic acid, citric acid, malic acid, glycolic acid, glycolic acid, or a mixture thereof
  • sodium hydroxide such as sodium hydroxide, sodium citrate, sodium lactate or mixtures thereof, but it is not limited thereto.
  • non-limiting examples of the surfactant include polyhydric alcohols including glyceryl monostearate, polyglyceryl-4isostearate, sorbitan monostearate and sugar ester monostearate; Polyoxyethylenemethylpolysiloxanes comprising ester-based PIG-8 dimethicone, PIG-10 dimethicone, PIG-9 methyletherdimethicone, PIG-3 dimethicone and PIG-11 methyletherdimethicone, of fatty acids Copolymers; Poly (oxyethylene-oxypropylene) methylpolysiloxane copolymer comprising sebum / fiji-20 / 20 butyletherdimethicone and sebum / fiji-20 / 20 dimethicone; And alkyl chain-silicone chain branched poly (oxyethylene-oxypropylene) methylpolysiloxane copolymers comprising cetyl-figage / fiji-10 / 1-dimethi
  • Non-limiting examples of the chelating agent sodium diphosphate, sodium triphosphate, 1-hydroxyethane-1,1-diphosphoic acid, nitrilotrimethylene phosphoic acid, nitrilotriacetic acid, Ethylenediaminetetraacetate, 1,2,3,4-cyclopentanetetracarboxylic acid, citric acid, O -carboxymethyltatron acid, O -carboxymethyloxysuccinic acid, and the like, and in particular, ethylenediamine It is preferable to use tetraacetate (for example, ethylenediaminetetraacetate-2Na, -3Na, -4Na, etc.).
  • tetraacetate for example, ethylenediaminetetraacetate-2Na, -3Na, -4Na, etc.
  • preservative examples include capryl glycol, paraoxybenzoic acid alkyl ester, benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, phenoxyethanol, paraben, pentanediol, benzoic acid, salicylic acid, dihydroacetic acid or The salts thereof, ethylhexylglycerin, 1,2-hexanediol, caprylglycol trophorone, p-oxybenzoic acid ester, 3-trifluoromethyl-4,4'-dichlorocarbavanide and 2,4,4'- Trichloro-2-hydroxydiphenyl ether and the like.
  • Non-limiting example of the oil is a silicone oil selected from cyclomethicone (Cyclomethicone), Methicone (Methicone), phenyltrimethicone (Phenyltremethicone) and Methiconol (Methiconol); And hydrocarbon oils selected from squalane, polybutene, polyisobutene, polydecene, hydrogenated polydecene, and the like.
  • the dyes, fragrances and pigments may be used in the art, of course, the pigments are azo, phthalocyanine, quinacridone, isoindolinone, perinone perylene, tren, Organic pigments selected from dioxazine, anthraquinone series, indigo series, aniline series, diketopyrrolopyrrole series, xanthene series, pyrene series, quinoline series, triphenylmethane series, fluorane series and / or insoluble salts thereof (Nat Salts of metals such as rings, potassium, calcium, barium, aluminum), and non-limiting examples include insoluble azo pigments or azo lake pigments [orange or red pigments (eg pigment red 1, 3, 4); ⁇ -naphthol-based azo pigments such as 6, 48, and 57: 1 (red 202); Condensed azo compounds, high molecular weight azo pigments, azomethine groups as well as pyrazorone
  • phthalocyanine-based pigments copper phthalocyanine, for example, blue pigments such as pigment blue 15 and 15: 3 (phthalocyanine blue), pigment green 7 (phthalocyanine green) and the like); Cridone pigments (such as purple pigments such as Pigment Violet 19), isoindolinone pigments (such as yellow pigments such as Pigment Yellow 110), perinone perylene pigments (red pigments such as Pigment Red 179, 190, etc.) ), Trench pigments (such as blue pigments such as Pigment Blue 60), dioxazine pigments (such as purple pigments such as pigment violet 23), anthraquinone pigments (pigment yellow 108, 123, blood Yellow, orange or red pigments such as cement red 83, 177, indigo or thio indigo pigments (blue pigments such as indigo, indigo white; purple pigments such as indirubin; red pigments such as
  • the freeze refrigerant according to an embodiment of the present invention is not limited if it can be maintained at a temperature of less than 10 °C but preferably selected from silicon oil, mineral oil, paraffin oil, liquid nitrogen, liquid oxygen, liquid air, etc. It may be one or more freeze refrigerant.
  • the method for producing an emulsion bead according to the present invention may be carried out at a temperature of -75 to 10 °C using the freeze refrigerant, preferably -30 to 20 °C, more preferably of -10 to 10 °C It is preferably carried out in the temperature range.
  • one or more selected from the lipid material and the gel-forming material may be included in the continuous phase.
  • the lipid material and the gel-forming material are coated with a feeling of use without foreign substances, and is not limited as long as it is a solid material at room temperature capable of forming a solid bead by a freezing refrigerant, but isostaryl alcohol, stearyl alcohol, cetyl Alcohol, cetostearyl alcohol, higher alcohols selected from behenyl alcohol, batyl alcohol, glyceryl monostearate, hexadecyl alcohol, and the like; Fatty acids selected from isostearic acid, oleic acid, lauric acid, stearic acid, palmitic acid, behenic acid and mystic acid; Petroleum waxes such as paraffin wax, polyethylene, wax, braze, beeswax and microcrystalline wax; Mineral waxes such as ozokerite and cere
  • examples of the gel-forming substance include agar, carrageenan, sodium alginate, locust gum, guar gum, tara gum, gum arabic, xanthan gum, hyaluronic acid, pectin, konjac, karaya gum, tragacanth gum, lach gum, dex Tran, starch, cellulose, gelatin, and derivatives thereof, but is not limited thereto.
  • the stability of the beads may not be affected. It is preferable at the point which can improve, Lipid substances, such as fatty acids, a lipid peptide; A gel-forming substance such as carrageenan or sodium alginate; and a substance having at least one anionic selected from.
  • the cationic polymer material not only makes the surface zeta potential of the finally produced emulsion beads have a (+) value, but surprisingly contained in the core layer It has been found that the stability of the active ingredient can be significantly improved.
  • the emulsion beads according to the present invention have surprising titer stability and storage stability compared to the primary beads.
  • the cationic polymer material is not limited as long as it is a material capable of forming a film, but preferred examples thereof include whey protein, collagen, gelatin, chitosan, cationic guar gum ( Cationic gua gum, polylysine (Polylysine), polyvinylamine (polyvinylamine), chitin (chitin) and the like may be one or more selected, preferably whey protein (collagen) (collagen), gelatin (Gelatin), The choice of chitosan, chitin, etc. is preferred in terms of being able to impart better cationic surface zeta potential.
  • the liquid emulsion may be prepared as a solid bead by mixing two or more different liquid emulsions and dropping them into one drop.
  • the liquid emulsion may be prepared by using a nozzle, the shape of the nozzle is not limited, but is preferably provided with a Y-shaped tip or a hollow tip.
  • the shell layer means a film prepared using a cationic polymer material, which can be formed of one or more layers as desired.
  • the thickness of the shell layer is not limited, but may be formed to a thickness of 10 ⁇ m to 200 ⁇ m from the surface of the core layer, it is preferably formed in the range of 10 ⁇ m to 100 ⁇ m, more preferably 10 ⁇ m to 50 ⁇ m It is good in terms of improving the stability of the effective material and giving a feeling of use without foreign matter.
  • the final emulsion beads prepared by the manufacturing method according to an embodiment of the present invention may have an average diameter in the range of 0.1 to 10 mm, the final form thereof is not limited.
  • the emulsion beads according to the present invention can be used without limitation as long as it is a cosmetic composition used in the art, non-limiting examples thereof softening cosmetics, astringent cosmetics, nutrient cosmetics, nutrition cream, massage cream, essence, eye cream And cosmetic compositions formulated with eye essences, packs, gels, body lotions, body creams, body oils, body essences and the like.
  • the emulsion beads according to the present invention may be contained in 0.1 to 20 wt%, relative to the total weight (100 wt%) of the cosmetic composition.
  • the liquid emulsion prepared by the above method was dropped through a 1.0 mm diameter nozzle (diameter 1 mm straight nozzle of sus material) at a rate of 5 mL / min, and dropped into a mineral oil cooled to 10 ° C.
  • Beads of the solid phase prepared by the above method were buried in the mineral oil component on the surface, and the washing process was performed to remove them.
  • the beads were placed in a 1.0 wt% surfactant (Tween 80, Daejung), and then washed for 10 minutes using an ultrasonic cleaner (SD-350H, ultrasonic power; 300 W, ultrasonic frequency; 40 KHz). It was. This washing process was also repeated five times and finally washed with water to prepare beads in the solid phase.
  • the prepared primary bead was confirmed that the average diameter of the sphere is formed to 2.5 mm.
  • 70 g of the primary beads prepared by the above method was added to 30 g of a polylysine solution (0.5 wt% in H 2 O, manufactured by Zhengzhou Bainafo Bioengineering), and stirred at 400 rpm for 1 hour to prepare core-shell emulsion beads.
  • Core-shell emulsion beads (spherical average diameter of 2.5 mm, the thickness of the shell layer 30 um was washed once with purified water.
  • the core-shell emulsion beads prepared by the above method were placed in a vial (50 ml) and stored in a room temperature (25 ⁇ 2 ° C.), a cold and thermostat bath (4 ⁇ 2 ° C.), and a high temperature thermostat (45 ⁇ 2 ° C.), and were separated for one week To evaluate the stability of each emulsion beads for 4 weeks, the results are shown in Table 2 below.
  • the core-shell emulsion beads prepared by the above method were put into a pumping container (100 ml) and pumped once on the back of the hand to evaluate the feeling of use and discomfort of the skin at the time of collapse of the emulsion beads, and the results are shown in Table 3 below. It was. The individual items were rated on a scale of 10.
  • Example 1 In preparing the emulsion beads of Example 1, except that the cationic guar gum solution (0.5wt% in H 2 O, product name; Esaflor EC4, manufacturer; Lamberti) instead of the polylysine solution was carried out in the same manner Core-shell emulsion beads (sphere average diameter 3.0 mm, shell layer thickness 50 um) were prepared.
  • the cationic guar gum solution 0.5wt% in H 2 O, product name; Esaflor EC4, manufacturer; Lamberti
  • Example 1 To prepare a liquid-in-water emulsion in the same manner as in Example 1 using the components shown in Table 1, after the preparation of the primary beads in the same manner as in Example 1 core-shell emulsion beads (spherical average diameter This thickness of 2.8 mm and the shell layer were 30 um).
  • Core-shell emulsion beads (a spherical average diameter of 3.0 mm, the thickness of the shell layer is 40 um) were prepared in the same manner as in Example 2 using the same liquid emulsion as in Example 3.
  • Example 1 To prepare a liquid-in-water emulsion in the same manner as in Example 1 using the components shown in Table 1, after the preparation of the primary beads in the same manner as in Example 1 core-shell emulsion beads (spherical average diameter 3.0 mm and the thickness of the shell layer were 40 micrometers).
  • Core-shell emulsion beads (a spherical average diameter of 4.0 mm, the thickness of the shell layer is 50 um) were prepared in the same manner as in Example 2 using the same liquid emulsion as in Example 5.
  • ⁇ relatively poor; The beads are partially collapsed, so that the components in the beads are oozed out
  • the stability to the temperature is superior to the comparative example, in particular in the high temperature of the bath over time Stability and mechanical strength have been dramatically improved to prevent the collapse of beads optimally to prevent the active ingredient from leaching out, and also to minimize the change in its potency.
  • the emulsion beads according to the present invention can be implemented with excellent feeling and application characteristics with a fresh feeling.
  • the emulsion beads according to the present invention is imparted with a cationic property to the outermost layer can not only stably penetrate into the skin active ingredients to help the skin whitening and wrinkle improvement without skin irritation with excellent feeling and application properties
  • stably including the active ingredients in the emulsion beads it is expected to maintain its stability for a long time, thereby improving the skin cosmetic effect.
  • emulsion beads that can modify the formulation's inherent form, color and / or texture, etc., it is possible to provide the user with visual enjoyment, aesthetic sensibility and enjoyment of makeup.

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Abstract

La présente invention concerne une bille d'émulsion et son procédé de fabrication, et plus spécifiquement, une bille d'émulsion stable de structure coeur-écorce et son procédé de fabrication, la bille d'émulsion comprenant une émulsion à l'état liquide contenant une substance active dont la stabilité est augmentée afin de maximiser un effet d'embellissement de la peau, et qui permet de satisfaire la sensation esthétique d'un utilisateur.
PCT/KR2016/002865 2016-03-21 2016-03-22 Bille d'émulsion et son procédé de fabrication WO2017164429A1 (fr)

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CN114617780A (zh) * 2020-12-11 2022-06-14 伽蓝（集团）股份有限公司 一种视黄醇衍生物油性凝胶珠、包含油性凝胶珠的皮肤护理组合物及制备方法
CN114762661A (zh) * 2021-01-12 2022-07-19 万华化学集团股份有限公司 一种低温稳定的核壳结构柔珠及其制备方法
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CN113234002A (zh) * 2021-04-24 2021-08-10 云南博浩生物科技集团股份有限公司 一种叶黄素晶体的产业化生产方法

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