WO2017195913A1 - Perles à émulsion solide contenant du dioxyde de titane et composition cosmétique de blanchiment immédiat les contenant - Google Patents

Perles à émulsion solide contenant du dioxyde de titane et composition cosmétique de blanchiment immédiat les contenant Download PDF

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WO2017195913A1
WO2017195913A1 PCT/KR2016/004906 KR2016004906W WO2017195913A1 WO 2017195913 A1 WO2017195913 A1 WO 2017195913A1 KR 2016004906 W KR2016004906 W KR 2016004906W WO 2017195913 A1 WO2017195913 A1 WO 2017195913A1
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Prior art keywords
emulsion
whitening
solid
oil
titanium dioxide
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PCT/KR2016/004906
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English (en)
Korean (ko)
Inventor
이재욱
정택현
강연복
김해란
오진주
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(주)케이피티
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Priority to PCT/KR2016/004906 priority Critical patent/WO2017195913A1/fr
Publication of WO2017195913A1 publication Critical patent/WO2017195913A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29—Titanium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin

Definitions

  • the present invention relates to solid emulsion beads containing titanium dioxide and cosmetic compositions for immediate whitening using the same, and more particularly to continuous lipid lipid or gel-forming substances solid at room temperature as immobilization components and titanium dioxide as immediate whitening components.
  • the present invention relates to a solid emulsion bead prepared by dropwise adding a liquid emulsion containing a phase to a freeze refrigerant, a preparation method thereof, and a cosmetic composition for whitening immediately after use thereof.
  • the present invention was performed as part of the economic cooperation zone industry development project supported by the Ministry of Trade, Industry and Energy for the development of functional cosmetics using the new formulation technology (Task No. A012100145).
  • Whitening cosmetics are cosmetics with the function of whitening skin, and contain whitening functional ingredients such as 'dough extract' (content 2% or more), arbutin (content 2-5%) or niacinamide.
  • whitening cosmetics commonly include "titanium dioxide (TiO2, titania)" as an immediate whitening component (immediate whitening component). Titanium dioxide is a UV-blocking ingredient and is widely used as a cosmetic raw material as a white colorant.
  • the instant whitening effect of commercially available instant whitening cosmetics is not due to the whitening functional ingredients but to the instant whitening ingredients such as titania. If you add too much titanium dioxide, it will be hard to apply, but if you add it properly, you can make your skin look white. If you add emulsifier such as silicone oil or cetylethylhexanoate, and add absorbent such as aluminum hydroxide and silica, It is known to create a smooth skin.
  • emulsifier such as silicone oil or cetylethylhexanoate
  • absorbent such as aluminum hydroxide and silica
  • the 'immediate whitening effect' is a cosmetic effect of a coloring agent that is not related to the whitening of the skin itself, and is a temporary effect that disappears after washing the face.
  • the immediate whitening effect can be seen as a 'brightening' effect rather than 'whitening' (whitening), but this distinction is not strictly applied.
  • Titanium dioxide is widely used as a sunblock component or white pigment in cosmetics because of its excellent whiteness and UV protection effect, but since it shows both fat soluble and water solubility, it is easy to move to an aqueous phase and an oil phase when contained in an emulsion. The interface between the aqueous and oil phases is disturbed, thereby lowering the stability and long-term storage of the emulsion.
  • silica which is easy to hydrate the surface of titanium dioxide, due to physical properties, there is a problem that aggregation of particles is easy and control of size is difficult.
  • Such particle cohesion and emulsion destabilization is a problem that not only titanium dioxide but also many inorganic particles have in common to some extent.
  • PCT / KR2013 / 002592 discloses solid emulsion beads containing lipid or gel-forming materials which are solid at room temperature in a continuous phase and methods for their preparation.
  • Korean Patent Application No. 10-2015-0061234 discloses a chemical, hygienic, dermatological or pharmaceutical active ingredient or activity in the continuous phase, discontinuous phase or both of the solid emulsion beads described above.
  • Formulations further containing additives selected from the components have been proposed, exemplified by the inorganic particles, organic particles, composite particles, microcapsules as additives.
  • the aforementioned inorganic, organic and multiparticulates are merely illustrated as a kind of cosmetic additives, and specific types or types of the aforementioned inorganic, organic and multiparticulates are not described, and specific examples or embodiments using them are described. Is not presented.
  • inorganic particles such as titanium dioxide may degrade the phase stability and the interfacail stability of the emulsion due to the aggregation and / or the phase shifting, resulting in emulsion instability in cosmetics. It limits the choice of formulation.
  • emulsion formulations such as creams and lotions
  • the lotion has a lower oil content than creams, which makes it easier to transport and aggregate titanium dioxide, which impairs emulsion stability and impairs particle application during skin application. The feeling of being pushed by the skin is low. Therefore, when titanium dioxide is applied to an emulsion formulation, a lot of oil formulation is used as a cream formulation with a higher oil content than a lotion formulation with a low oil content, and the problem due to the emulsion instability still occurs.
  • the present invention provides a new emulsion formulation and a method for preparing the same that can solve the problems of particle coagulation, emulsion instability and resulting formulation instability when applying titanium dioxide to emulsion formulations such as creams and lotions.
  • the present inventors have added a liquid emulsion containing a lipid or gel-forming substance which is a solid at room temperature as an immobilized component in the continuous phase of the emulsion and titanium dioxide as an immediate whitening component to a freeze refrigerant, and the cosmetic composition for immediate whitening of the solid emulsion beads.
  • titanium dioxide is contained in the stationary phase, and thus, aggregation and migration are prevented, thereby finding that the stability and long-term storage of the emulsion are not reduced.
  • the whitening cosmetic compositions according to the invention can be prepared in any emulsion formulations such as creams, lotions and the like, wherein the aforementioned immobilization ingredients can further improve the dispersibility and skin applicability of titanium dioxide.
  • an instant whitening cosmetic composition containing titanium dioxide as an instant whitening component includes titanium dioxide as an instant whitening component in a continuous phase immobilized with a lipid or a gel-forming material which is solid at room temperature as an immobilizing component, Particle agglomeration and migration are prevented to provide excellent emulsion stability and long-term storage, and the dispersibility and skin coverage of titanium dioxide can be improved by the immobilized components.
  • FIG. 1A is a photograph showing cosmetic preparations for whitening immediately after submerged solid emulsion beads of white appearance prepared in Example 1 and containing immobilized component and titanium dioxide in a continuous phase
  • FIGS. 1B and 1C show the white appearance described above. This photo shows the appearance of the solid emulsion beads before applying to the back of the hand and the immediate whitening effect after the application.
  • Figure 2a is a photograph showing the appearance of a cosmetic for whitening immediately after the solid emulsion beads of the pink appearance prepared in Example 2 containing the immobilized component and titanium dioxide in the continuous phase submerged in the base
  • Figures 2b and 2c is a pink This photo shows the appearance of the solid emulsion beads on the back of the hand and the immediate whitening effect after the application.
  • a first object of the present invention is to provide a cosmetic composition for immediate whitening using solid emulsion beads comprising a lipid or gel-forming substance which is a solid at room temperature as an immobilization component in an emulsion phase and titanium dioxide as an immediate whitening component. It is.
  • the above-mentioned emulsions are emulsions of water-in-oil (W / O), oil-in-water (O / W), oil-in-water (W / O / W), or water-in-oil (O / W / O) types. It may be selected from, preferably an oil-in-water emulsion, and the above-mentioned continuous phase is an aqueous phase.
  • a second object of the present invention is to provide a solid emulsion bead comprising a lipid or gel-forming substance which is a solid at room temperature as an immobilization component in the continuous phase of the emulsion and immediately containing titanium dioxide as a whitening component in the resulting fixed phase.
  • said solid emulsion beads are added to a base selected from the group consisting of cosmetic, hygienic, dermatological or pharmaceutical compositions.
  • It is a third object of the present invention to provide an immediate whitening cosmetic comprising the following component (a) and component (b):
  • a cosmetic composition for immediate whitening comprising solid emulsion beads containing a lipid or gel-forming substance which is a solid at room temperature as an immobilizing agent and a titanium dioxide as a whitening agent in a continuous or discontinuous phase, and
  • a base selected from the group consisting of cosmetic compositions, hygiene compositions, dermatological compositions or pharmaceutical compositions.
  • Emulsion beads are prepared. Bringing the resulting solid emulsion beads back to room temperature causes the frozen solid aqueous phase to liquefy again, resulting in the emulsion beads being unable to maintain their solid state and bead form.
  • a water-in-oil type liquid emulsion is prepared by adding a solid material at room temperature to a gel-forming substance such as agar (agar), and dropping the resulting liquid emulsion in the form of beads on a freeze refrigerant as described above.
  • the aqueous phase is frozen to give solid emulsion beads.
  • the solid aqueous phase that was frozen forms gels due to the gel-forming material contained therein or remains solid due to materials that are solid at room temperature, thus not liquefying again and consequently solid
  • the state and the shape of the beads can be maintained as it is (cf. PCT / KR2013 / 002592 and Korean Patent Application No. 10-2013-0145083).
  • gel-forming materials which can be used as immobilization components in the present invention and lipids which are solid at room temperature are described in the foregoing prior documents, which are incorporated herein in their entirety.
  • gel-forming materials usable in the present invention, mention may be made of gel-forming polymers such as cationic polymers, gum materials such as indigum and guar gum, carrageenan, agar and mixtures thereof.
  • plant exudate such as tragacanth gum and gum arabic
  • Plant seed rubbery materials such as grasshopper soybean gum and guar gum
  • Semisynthetic rubbery materials such as CMC (carboxy methyl cellulose), hydroxypropylcellulose and methylcellulose
  • Seaweed extracts such as propylene glycol alginate
  • Fermentation products such as xanthan rubber and dextran
  • substances such as low methoxy pectin.
  • the amount of the gel-forming substance described above is not particularly limited, but is 0.1 to 5% by weight, particularly 0.2 to 4% by weight, preferably 0.4 to 3% by weight, more preferably 0.5 to the total weight of the bead emulsion beads. It may be contained in an amount of ⁇ 2% by weight. If the content is 0.1% by weight or less, the resultant bead emulsion beads are difficult to maintain at room temperature, and above 5% by weight, the bead emulsion beads may not be broken well at room temperature or the foreign body may increase the feeling of foreign matter.
  • the lipid material which is a solid at room temperature usable in the present invention it can be exemplified that it is a solid at room temperature and has a melting point of at least room temperature, specifically 40 ° C or more, particularly 50 to 100 ° C, preferably 60 to 80 ° C.
  • Specific examples of lipids that are solid at room temperature include behenyl alcohol, cetyl alcohol (mp 49 ° C.), stearyl alcohol (mp 69 ° C.), glyceryl monostearate, higher alcohols such as cetostearyl alcohol or batyl alcohol, fatty acids. Mention may be made of lipid peptides and mixtures thereof.
  • the amount of the lipid material that is solid at room temperature is not particularly limited, but is 0.1 to 10% by weight, particularly 0.2 to 7% by weight, preferably 0.3 to 5% by weight, more preferably of the total weight of the bead emulsion beads. May be used in an amount of 0.5 to 5% by weight. If the content is 0.1% by weight or less, the resultant bead emulsion beads are difficult to maintain at room temperature, and above 10% by weight, the bead emulsion beads may not be broken well at room temperature or may cause an increase in foreign body feeling.
  • solid emulsion beads may be prepared in the form of emulsions of two or more compositions coexisting in one bead by using two or more emulsions having the same or different composition together.
  • Emulsions having the same or different compositions described above may be prepared in layered form with the same circumference.
  • two or more emulsions having different functions e.g. color, fragrance
  • composition composition ratio, composition
  • the method for producing beaded emulsion beads having a layered structure from two or more emulsions having different functions may be applied to cosmetics using a color delivery system.
  • the solid emulsion beads which can be used in the above-mentioned immediate whitening cosmetic composition comprise a lipid or gel-forming substance which is solid at room temperature as an immobilization component, and the resulting The stationary phase contains titanium dioxide as an immediate whitening component, which may be prepared by a method comprising the following steps (i) to (v):
  • said solid emulsion beads are added to a base selected from the group consisting of cosmetic, hygienic, dermatological or pharmaceutical compositions.
  • the discontinuous phase of the emulsion can be prepared by conventional methods.
  • the continuous phase aqueous phase
  • the continuous phase may be prepared by adding a water-soluble additive to water, and in some cases by heating to a temperature of 50 to 90 ° C. to dissolve the discontinuous phase (oil phase) in the oil. It may be prepared by adding oil-soluble additives and, if desired, dissolving by heating to a temperature of 50 to 90 °C.
  • Additives can be exemplified by the active substances described below in the detailed description of the invention.
  • the continuous phase of the emulsion can also be prepared in a conventional manner, for example in the case of oil-in-water emulsions, as described above, water soluble additives are added to the water, and in some cases 50 to 90 ° C. It can be dissolved by heating to a temperature of to produce a continuous phase (aqueous phase).
  • a continuous phase comprising an immobilized component and an immediate whitening component can be prepared by simultaneously or sequentially adding the immobilized component and the immediate whitening component to the medium and, if necessary, heating to a temperature of 50 to 90 ° C.
  • the above-described continuous phase is preferably an aqueous phase.
  • the order of including the immobilized component and the immediate whitening component in a continuous or discontinuous phase is not limited and may be added simultaneously or sequentially.
  • the immobilization component and titanium dioxide are simultaneously added to the continuous phase medium and stirred while heating to a temperature of 50 to 90 ° C. as necessary, so that the aforementioned immobilization component is dissolved or melted in the medium and the titanium dioxide is dispersed in the medium. You can.
  • the above-mentioned immediate whitening component can be included in both continuous and discontinuous phases.
  • the liquid phase in which the discontinuous phase is dispersed in the continuous phase can be prepared by introducing the discontinuous phase into the continuous phase with stirring.
  • the discontinuous phase For example, by dispersing by adding discontinuous phases containing no immobilized component and immediate whitening component without discontinuous phase, or by adding discontinuous phases containing them with continuous phase not including immobilized component and immediate whitening component Can be dispersed.
  • an aqueous phase containing an immobilized component and an instant whitening component is introduced under stirring with an oil phase containing no immobilized component and an immediate whitening component, thereby including the immobilized component and the immediate whitening component in a continuous phase (aqueous phase).
  • a water-in-oil type liquid emulsion can be prepared.
  • the temperature of the continuous phase and the discontinuous phase is a temperature at which the immobilized component is not solidified or gelled, for example, 40 to 100 ° C, preferably 50 to 90 ° C, more preferably 60 to 80 ° C. It is good to have a temperature of. If the temperature is too high, the medium may evaporate or the additive may be denatured. If the temperature is too low, the immobilization may proceed during the process.
  • the immobilization temperature means a temperature at which the immobilization component is solidified or gelled, and it is preferable to use an immobilization component having an immobilization temperature of 50 to 90 ° C from the viewpoint of manufacture and use of cosmetics.
  • the freeze coolant can be maintained at a temperature below room temperature, preferably below 10 ° C, more preferably below 0 ° C.
  • the freeze refrigerant is sufficient to be at a temperature at which the immobilized component (lipid or gel-forming material which is solid at room temperature) contained in the continuous phase can be solidified or gelled, for example, 10 ° C. or less.
  • the liquid emulsion which is usually heated to 50 to 90 ° C., is cooled to a temperature of room temperature or lower, solidification or gelation may be performed due to the immobilization component included in the continuous phase. Therefore, the liquid emulsion beads can be converted to solid emulsion beads even when the freeze refrigerant has a temperature of 0 ° C. or more and room temperature or less.
  • the freeze refrigerant usable in the present invention is not particularly limited as long as it can be easily removed from the resulting solid emulsion beads without breaking the liquid emulsion added in the form of beads.
  • liquefied gases e.g., liquefied oxygen, liquefied nitrogen, liquefied air
  • oils that are liquid and fluid at low temperatures e.g. silicone oils and mineral oils
  • liquefied hydrocarbons, etc. may be mentioned.
  • silicone oils or mineral oils which may be used as cosmetic bases.
  • the droplet size (diameter or longest distance) of the emulsion may be 0.5-20 mm, specifically 1-10 mm, preferably 2-8 mm, particularly 3-6 mm.
  • the droplets of the emulsion can be adjusted to the desired size and / or shape by appropriately adjusting the emulsion viscosity, nozzle diameter and injection pressure, and those skilled in the art will appreciate the desired droplets by appropriately adjusting and combining the emulsion viscosity, nozzle diameter and injection pressure.
  • the size and / or shape may be appropriately selected.
  • the titanium dioxide (titania) powder used immediately as a whitening ingredient is not particularly limited as long as it can be normally used in cosmetics. Titanium dioxide is generally used in amounts of 2-3% in sunscreens (5% or less with zinc oxide), 1 ⁇ 2% in sunsprays (3% or less with zinc oxide) and 0.5-1% in cosmetics such as creams. . Sun cream or cream cosmetics may contain titanium dioxide in an amount of up to 25%, but if the amount of titanium dioxide is too large, there is a problem that turbidity occurs.
  • titanium dioxide has excellent whiteness and ultraviolet ray blocking effect and is widely used as a sunblock component or a white pigment in cosmetics.
  • titanium dioxide shows both fat solubility and water solubility, when contained in the emulsion, the stability of the emulsion becomes unstable and the long-term storage of the emulsion is lowered.
  • titanium silica has a problem that, unlike silica, physical particles are easy to aggregate and difficult to control the size.
  • the stationary phase (continuous or discontinuous phase) of the emulsion containing the immobilized component is solidified or gelled through a freeze-heating process, whereby the movement and movement of the fixed phase and its components are substantially stopped ( Hereinafter referred to as immobilization).
  • immobilization the continuous phase or the discontinuous phase is fixed to become a stationary phase
  • titanium dioxide contained in the fixed phase is also fixed together, thereby preventing destabilization of the emulsion due to movement of the titanium dioxide particles and aggregation due to collision of the titanium dioxide particles.
  • the titanium dioxide particles may be included in the fixed phase, the non-fixed phase (or the fluidized phase), or both, but from the viewpoint of particle aggregation and interfacial stability, it is preferable to include only the fixed phase. If the titanium dioxide particles are included in the non-fixed phase, not only there is a problem of aggregation, but also a problem of disturbing the non-fixed phase may occur by moving from the inside of the phase to the trademark surface (interface).
  • the components used as immobilization components i.e., lipids or gel-forming substances which are solid at room temperature, can improve the dispersibility of titanium dioxide in the organic phase or the aqueous phase, and have a foreign matter or matte of titanium dioxide powder when applied to the skin. It can play a role in reducing feeling.
  • the solid emulsion beads described above are at least 0.01% by volume, specifically 0.1% by volume, based on the volume of the base, selected from cosmetic, dermatological, hygienic or pharmaceutical compositions. It may be included in an amount of at least%, preferably at least 1% by volume, particularly at least 5% by volume.
  • the cosmetic container since the cosmetic container may be filled with the solid emulsion beads, then all or part of the empty space between the solid emulsion beads may be filled with a base, so that the upper limit of the amount of the emulsion beads added is not limited.
  • the base described above is an aqueous solution product in which all components are completely or substantially dissolved in water, a solubilized product in which a small amount of oil is transparently dissolved in water by a surfactant, and an oil component in water is colored by a surfactant. And emulsified product in a turbid state, and / or fine solid particles in water or oil may have the form of a dispersed product uniformly dispersed by a surfactant.
  • cosmetic, skin, hygienic or pharmaceutical active ingredients or active ingredients are added to the emulsion beads by adding a cosmetic, dermatological, hygienic or pharmaceutical active phase to the continuous or discontinuous phase of the emulsion of the solid emulsion beads described above.
  • Pharmaceutically, hygienically or pharmaceutically can impart desired properties.
  • the active ingredients mentioned above are organic, natural or synthetic, inorganic, natural or synthetic, including but not limited to cosmetic oils, pulsating waxes, emulsifiers, emolients, stabilizers, biogenic agents. Mention may be made of vitamins, natural extracts, essential oils, UV-protectors, antioxidants, preservatives, repellents, self-tanning agents, tyrosine inhibitors (bleaches), perfume oils and pigments.
  • the active substance may retain biological and / or therapeutic activity or have several activities that are important for skin care.
  • One or more functional / multifunctional actives are moisturizers, healing / regenerating / activating agents, bleaching / whitening / lightening agents, antioxidant / radical removers, cooling / soothing agents, warming agents, anesthetics, sunscreens / sunblocks, sun tanning agents , Antibiotics, anticellulite, keratin, antifungal, anti psoriasis, anti-inflammatory, antibacterial, astringent, antiseptic, repellent, anti spider, antirosacea / anti-couperosis, anti acne Agent, perfume / fragrance and thermal blister treatment.
  • the active substance can be microencapsulated or unencapsulated.
  • sensitive or labile active substances can be microencapsulated.
  • active agents such as vitamins, oils, natural extracts, essential oils, fragrances such as perfumes and topical drugs such as antibiotics are microencapsulated and effectively protected in monolayer microcapsules. More preferably, active agents such as vitamins, natural extracts, essential oils, naturally occurring individual compounds and topical therapeutic agents may be encapsulated in double- or multi-layered microcapsules.
  • active substances having beneficial properties for the skin are any vegetable oils and herbal extracts, including natural extracts such as essential oils used for topical use.
  • Herbal extracts or vegetable oils are preferably microencapsulated.
  • Preferred herbal extracts and vegetable oils include, but are not limited to, licorice, a whitening and anti-spot preparation known to be useful in the treatment of senile plaques, blemishes during pregnancy, hyperpigmentation after inflammation, and to interfere with tyrosinase and melanin synthesis.
  • Root extract Grape seed extract, which is an antioxidant / free radical scavenger, sunscreen / sunblock, and antifungal agent that maintains the best antioxidant activity when encapsulated; Borage oil, which is a moisturizing, soothing, antioxidant / free radical scavenger and anti-inflammatory agent; Jojoba oil, a moisturizing anti-inflammatory agent; Evening primrose oil as an antioxidant / free radical scavenger and moisturizing, soothing, regenerating / activating; Vitamin Tree Oil (Hippophae / Sea Buckthorn), which contains stable high concentrations of multivitamins and carotenoids, is beneficial as a skin regenerant, and has a calming and anti-inflammatory effect; Tea tree oil, which is a natural antibacterial, antiseptic, antifungal, healing / regenerating / activating effect and anti-inflammatory agent useful for the treatment of acne, psoriasis, vaginitis, etc .; Carrot seed extract and oils useful as healing / regeneration / activators; Camelli
  • the active substance with beneficial properties to the skin is vitamins (eg vitamins A, B, C, D, E, F, K, P) or mixtures thereof.
  • the composition comprises microcapsules comprising one or more of the following vitamins: in the form of vitamin A, free form of retinol or ester form of retinol palmitate, skin regeneration, whitening / lightening, keratinous dissolution, anti acne, Useful as anti-psoriasis and anti-inflammatory agents; Useful as vitamin C (ascorbic acid) and derivatives thereof, antioxidant / free radical scavenger, whitening / lightening and anti-psoriasis; As vitamin E, preferably alpha-tocopherol, useful as antioxidant / free radical scavenger and anti-inflammatory agent; Mixtures of vitamin F, unsaturated linoleic acid and alpha-linolenic fatty acids, also known as essential fatty acids (EFA), are important for skin health and function as mois
  • EFA essential fatty
  • polyphenols eg tannins, flavonoids and lignin
  • saponins e.g., glutathione, glutathione, glutathione, glutathione, glutathione, glut
  • the active agent is a pharmaceutical agent suitable for skin use, such as, but not limited to, antibiotics such as erythromycin, azithromycin or clarithromycin, or any as defined below.
  • antibiotics such as erythromycin, azithromycin or clarithromycin, or any as defined below.
  • the active substances used in the present invention can be classified into the following categories:
  • moisturizing or wetting agents such as, but not limited to, evening primrose oil, borage oil, jojoba oil, aloe vera gel, vitamin F, panthenol, and mixtures thereof;
  • healing / activation / regenerating agents such as, but not limited to, vitamin tree oil, tea tree oil, vitamin A, allantoin and derivatives, carotenoids, caroteside extracts and oils, patchouli essential oils, and mixtures thereof
  • bleaching / lightening agents such as, but not limited to, Licorice (Gycyrrhiza Glabra) root extract, arbutin, kojic acid, hardoquinone, beta-hydroxy acids such as salicylic acid, alpha hydroxy acids , Vitamin C and derivatives, and mixtures thereof;
  • antioxidant / free radical scavengers such as, but not limited to, vitamin E, tocotrienols, tocopherols, vitamin F, vitamin C and derivatives thereof, rutin, resveratrol and derivatives thereof, camelia sinensis leaf extract (green tea or black tea), Grape seed extract, evening primrose oil, borage oil, ginger essential oil, curcumin, chitosan, carotenoids, and mixtures thereof;
  • cooling and sedatives such as, but not limited to, menthol, aloe barbadensis leaf extract, camphor, methylsalicylate, menthyllactate, allantoin, bisavaol, chamomile extract and essential oil, evening primrose oil, Borage oil, eucalyptus citridora essential oil, fazulie essential oil, panthenol, and mixtures thereof;
  • warming agents such as, but not limited to, pepper extracts and essential oils, paprika (red pepper) extracts, cinnamon extracts and essential oils, ginger extracts and essential oils, zeolites; And mixtures thereof;
  • anesthetics such as, but not limited to, aloe barbadensis gel (aloe veragel), benzocaine, lidocaine, dibucaine, pramoxin, tetracaine, camphor, resorcinol, and mixtures thereof;
  • sunscreens / sunblock agents such as, but not limited to, p-aminobenzoic acid (PABA) and its esters, benzalzalides, benzophenones, cinnamates, etocrylene, octocrylene, salicylates, Grape seed extract, titanium dioxide, zinc oxide, and mixtures thereof;
  • PABA p-aminobenzoic acid
  • sunscreens / sunblock agents such as, but not limited to, p-aminobenzoic acid (PABA) and its esters, benzalzalides, benzophenones, cinnamates, etocrylene, octocrylene, salicylates, Grape seed extract, titanium dioxide, zinc oxide, and mixtures thereof;
  • PABA p-aminobenzoic acid
  • sunscreens / sunblock agents such as, but not limited to, p-aminobenzoic acid (PABA) and its esters, benzalzalides, benzophen
  • tanning agents such as, but not limited to, 1,3-dihydroxyacetone, melanin, makhacani, erythrulose, 5-hydroxy-1,4-naphthoquinone, 5-hydroxy -1,4-naphthoquinone, and mixtures thereof;
  • topical antibiotics such as, but not limited to, erythromycin, clarithromycin, azithromycin and clindamycin;
  • anticellulite agents such as, but not limited to rutin hydrate, quentin, caffeine, theophylline, theobromine, aminophylline, and mixtures thereof;
  • keratoses useful in the treatment of acne, warts and other skin diseases such as, but not limited to, salicylic acid and other beta-hydroxy acids, alpha hydroxy acids such as glycolic acid, benzoyl peroxide, sulfur, isotretinoin, tretinoin , Aminolevulinic acid, pullulurouracil, grapephytotoxin, grapephylum, proylene glycol, phytic acid, and mixtures thereof;
  • antibacterial agents such as, but not limited to, antibiotics, chamomile essential oils
  • antifungal agents such as, but not limited to, tea tree oil, grape seed extract, eucalyptus citridora essential oil, ursolic acid, essential oil, amphotericin, itaconasol, fluconazole, ketoconazole, myconazole, morpholine , Undecylenic acid, and mixtures thereof;
  • (xv) anti-acne agents such as, but not limited to, benzoyl peroxide, tretinoin, isotretinoin, chamomile essential oil, and mixtures thereof;
  • anti-psoriasis agents such as, but not limited to, retinoids, vitamin A, vitamin C, vitamin D3 and analogs thereof, ergocalciferol, carotenoids, anthrallines, metronidazole, tazarotene, cyclosporine, pyrogalol , Allantoin, and mixtures thereof;
  • anti-inflammatory agents such as, but not limited to, vitamin F, vitamin E, carotenoids, vitamin A, unsaturated fatty acids, rutin, bioflavanoids, vitamin oil, olive oil, salicycin, ginger extract and essential oils, jojoba Oils, chamomile essential oils, eucalyptus citridora essential oils, ursolic acid, triamcinolone, cortisone, prednisone, cortodoxone, flucetonide, medridone, amcinofel, amcinamide, betamethasone and its esters, clocotelone , Dessinolone, desonide, fluchloronide, flumethasone, flunisolide, fluorinide, flucortolone, paramethasone, dexamethasone, fluroandronolone acetonide, acetonide, dichlorison, and mixtures thereof ;
  • astringents such as, but not limited to, witch hazel (Hamamalas vulginania), yarrow (achillamilefolium), rosewood oil, benzoin, aluminum sulfate and other aluminum salts, salicylic acid, zinc oxide, And mixtures thereof;
  • (xix) preservatives such as, but not limited to, honey, curcumin, captan, chlorhexidine and derivatives thereof, hexachlorophene, triclosan, triacetin, sodium usnate, sulfur, and mixtures thereof;
  • repellents such as, but not limited to, essential oils, pyrethrins, permethrins, bioresmethin, dimethylphthalate, and mixtures thereof;
  • antirosacea agents such as, but not limited to, vitamin K, sulfur, marigold oil, rutin, bioflavonoids, and mixtures thereof;
  • active substances beneficial for topical treatment of febrile blisters including but not limited to: acyclovir, antihistamines, local anesthetics, essential oils with antiviral activity, and The mixture;
  • (xxiii) but not limited to, lavender, neroli balm, chamomile essential oil, ginger essential oil, pacific essential oil, eucalyptus citridora essential oil, rosemary essential oil, sandalwood essential oil, tea tree oil Perfumes and perfumes, and mixtures thereof.
  • microencapsulated menthol which provides cosmetic formulations with a refreshing feel, cooling effect, soothing performance and short-term relief.
  • Microcapsules comprising 10% menthol are used according to the invention in skin care products selected from sunscreen products, after cooling sun exposure lotions, soothing creams and refreshing shaves before and after products.
  • the invention includes active substances and colorants approved by the Personal Care Products Council (formerly Cosmetics, Toiletries and Fragrance Combinations, Cosmetics, Toiletry and Fragrances Association, CTFA) and the Food and Drug Administration (FDA). It is.
  • the microcapsules of the present invention do not contain ethanol.
  • Purified water (component 1) is added to the main mixer, and as the aqueous phase components (components 2 to 10), bifunctional niacinamide, adenosine, moisturizer 1,3-propanediol, preservative 1,2-hexanediol, and instant whitening component titanium dioxide ( TiO 2 ), emulsifier HCO-40, Lipoid P 75-3, immobilizing agent agar (agar) and whitening aid pearl 9002D were sequentially added in the amounts shown in Table 1 and dispersed under stirring. The resulting mixture was heated and dissolved at 95 ° C. to prepare an aqueous phase.
  • Oil phase components (components 11-14) were mixed in the amounts shown in Table 1 below, and the resulting mixture was heated and dissolved at 70-75 ° C. to prepare an oil phase.
  • the aqueous phase prepared in (1) was introduced into the main mixer and stirred.
  • An oil-in-water liquid emulsion was prepared by adding the oil phase prepared in (2) to 68-70 ° C. while maintaining the oil phase in the aqueous phase of the main mixer and emulsifying it under stirring.
  • Solid emulsion beads were prepared by dropping the liquid emulsion prepared in (3) dropwise into the silicone oil (10 ° C. or lower) through the nozzle tip while maintaining the liquid emulsion at approximately 70 ° C.
  • the obtained solid emulsion beads have the shape of beads having a diameter of approximately 6.5 to 7.5 mm, and has the weight composition of Table 1 below.
  • the obtained solid emulsion beads (ton up ring capsules) are applied to the skin and rubbed away without leaving any foreign materials and exhibit an instant whitening effect on the skin by TiO 2 and Pearl 9002D (see FIGS. 1A, 1B and 1C).
  • Purified water (component 1) was added to the main mixer, and as an aqueous phase component (components 2 to 9 and 11), thickener RICE NS 9090, moisturizer 1,3-propanediol, preservative 1,2-hexanediol, and instant whitening component titanium dioxide (TiO2) SD Titan-200, emulsifier HCO-40, Lipoid P 75-3, immobilizing agent agar (agar) and carrageenan, whitening aid component 9001E were sequentially added in the amounts shown in Table 2 and dispersed under stirring. The resulting mixture was heated and dissolved at 95 ° C. to prepare an aqueous phase.
  • aqueous phase component component 2 to 9 and 11
  • thickener RICE NS 9090 moisturizer 1,3-propanediol
  • preservative 1,2-hexanediol preservative 1,2-hexanediol
  • instant whitening component titanium dioxide (TiO2) SD Titan-200 e
  • Oil phase components (components 12-15) were mixed in the amounts shown in Table 2 below, and the resulting mixture was heated and dissolved at 72-74 ° C. to prepare an oil phase.
  • the aqueous phase prepared in (1) was introduced into the main mixer and stirred.
  • An oil-in-water liquid emulsion was prepared by adding the oil phase prepared in (2) to 68-70 ° C. while maintaining the oil phase in the aqueous phase of the main mixer and emulsifying it under stirring.
  • Disperse pigment (component 10) was prepared by mixing and dispersing in a proportion of 95% by weight of dipropylene glycol (DPG) and 5% by weight of pigment Sunpuro Red (iron oxide).
  • DPG dipropylene glycol
  • Sunpuro Red iron oxide
  • Disperse pigment (component 10) was added to the obtained liquid emulsion in the amounts shown in Table 2 and emulsified to prepare a liquid emulsion having a pink appearance.
  • the temperature of the liquid emulsion Maintain at 70 ° C.
  • Solid emulsion beads were prepared by dropping the liquid emulsion prepared in (3) dropwise into the silicone oil (10 ° C. or lower) through the nozzle tip while maintaining the liquid emulsion at approximately 70 ° C.
  • the obtained solid emulsion beads had the form of pink beads having a diameter of approximately 6.5 to 7.5 mm, and has the weight composition of Table 2 below.
  • the obtained round-shaped whitening capsule was applied to the skin and rubbed by hand, and all disappeared without leaving any foreign material, and exhibited an immediate whitening effect on the skin by SD TiTAN-200 and Pearl 9001E.
  • the proper mixing ratio of the two immobilizing agents (agar, carrageenan) and the addition of water-soluble silicones provide a very soft feeling of use (see FIGS.
  • Solid emulsion beads of a cream formulation containing 25% oil were prepared as follows to prepare a whitening cosmetic immediately.
  • Purified water (component 1) and serum base KF15001 (component 2) were added to the main mixer, and as an aqueous phase component (components 3 to 11), a moisturizer 1,3-propanediol, preservative 1,2-hexanediol, and conditioning agent ethylhexyl glycerin 40, Lipoid S 75-3, salicylic acid, immobilizing agent agar (agar) and carrageenan, bifunctional niacinamide and adenosine (components 12-13) were sequentially added in the amounts shown in Table 3 and dispersed under stirring. The resulting mixture was heated and dissolved at 95 ° C. to prepare an aqueous phase.
  • the oil phase component (component 14) was heated to 72-74 ° C. and then maintained at 68-70 ° C. to prepare an oil phase.
  • the aqueous phase prepared in (1) was introduced into the main mixer and stirred.
  • An oil-in-water liquid emulsion was prepared by adding the oil phase prepared in (2) to the aqueous phase of the main mixer while maintaining the temperature of the aqueous phase at about 5 to 10 ° C. and emulsifying it under stirring. .
  • the fragrance (component 15) is added and homogenized, and then the temperature is maintained at 70 ° C.
  • Solid emulsion beads were prepared by dropping the liquid emulsion prepared in (3) dropwise into the silicone oil (10 ° C. or lower) through the nozzle tip while maintaining the liquid emulsion at approximately 70 ° C.
  • the obtained solid emulsion beads had the form of white beads having a diameter of approximately 7.5 to 8.5 mm, and has the weight composition of Table 2 below.
  • the obtained round-shaped whitening capsule is applied to the skin and rubbed by hand, and disappears without leaving any foreign substance, and shows an instant whitening effect on the skin by the instant whitening agent titanium dioxide, and the vegetable oil Phyto horse oil (Phyto horse oil) is It is contained in high content and shows high moisturizing effect on skin.
  • the proper mixing ratio of the two fixing agents agar, carrageenan
  • bifunctional niacinamide and adenosine help to whiten and improve wrinkles.
  • Immediately whitening cosmetics according to the present invention and a method for producing the same can be used industrially in the cosmetic industry.

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Abstract

La présente invention concerne : une composition cosmétique de blanchiment immédiat constituée de perles à émulsion solide préparées par égoutture, dans un réfrigérant de congélation, d'une émulsion liquide contenant un matériau lipidique ou un matériau gélifiant, solide à température ambiante, servant d'ingrédient de fixation, et du dioxyde de titane servant d'ingrédient de blanchiment immédiat dans la phase continue d'une émulsion; et un procédé de préparation de cette composition. Comme le dioxyde de titane contenu dans les perles à émulsion solide selon l'invention est inclus dans une phase continue fixe, empêchant ainsi la coagulation et le mouvement, la stabilité et l'aptitude au stockage de longue durée sont préservées. En outre, la composition cosmétique de blanchiment selon l'invention peut être préparée sous n'importe quelle forme d'émulsion, telle qu'une crème, une lotion et analogue, et l'ingrédient de fixation peut également améliorer la dispersibilité et l'applicabilité sur la peau du dioxyde de titane.
PCT/KR2016/004906 2016-05-11 2016-05-11 Perles à émulsion solide contenant du dioxyde de titane et composition cosmétique de blanchiment immédiat les contenant WO2017195913A1 (fr)

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Cited By (1)

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WO2020138569A1 (fr) * 2018-12-28 2020-07-02 주식회사 케이피티 Procédé de fabrication de double capsule dispersée dans l'huile et double capsule dispersée dans l'huile fabriquée à partir de celui-ci

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KR20140144264A (ko) * 2013-03-28 2014-12-18 (주)케이피티 저온냉각에 의한 구슬형 에멀젼 비드의 제조방법 및 수득된 구슬형 에멀젼 비드

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KR100903896B1 (ko) * 1999-07-13 2009-06-19 체엘에르-헤미쉐스 라보라토리움 독토르 쿠르트 리히터 게엠베하 건강상 해로운 자외선으로부터 보호하고 천연 피부보호막을 강화시키기 위한 자외선 보호용 조성물
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KR20110084151A (ko) * 2008-07-31 2011-07-21 솔-겔 테크놀로지스 리미티드 활성성분을 포함하는 마이크로캡슐 및 금속 산화물 쉘, 그의 제조방법 및 그의 용도
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020138569A1 (fr) * 2018-12-28 2020-07-02 주식회사 케이피티 Procédé de fabrication de double capsule dispersée dans l'huile et double capsule dispersée dans l'huile fabriquée à partir de celui-ci
EP3903763A4 (fr) * 2018-12-28 2022-11-16 KPT Ltd Procédé de fabrication de double capsule dispersée dans l'huile et double capsule dispersée dans l'huile fabriquée à partir de celui-ci

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