WO2017164275A1 - Composition pour amélioration de l'environnement de la cavité buccale - Google Patents

Composition pour amélioration de l'environnement de la cavité buccale Download PDF

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Publication number
WO2017164275A1
WO2017164275A1 PCT/JP2017/011619 JP2017011619W WO2017164275A1 WO 2017164275 A1 WO2017164275 A1 WO 2017164275A1 JP 2017011619 W JP2017011619 W JP 2017011619W WO 2017164275 A1 WO2017164275 A1 WO 2017164275A1
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composition
propionic acid
bacteria
oral
acid bacteria
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PCT/JP2017/011619
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English (en)
Japanese (ja)
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聡美 伊藤
理子 澤▲崎▼
研一 北條
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株式会社明治
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Priority to JP2018507389A priority Critical patent/JP7107835B2/ja
Priority to CN201780018624.8A priority patent/CN109152728B/zh
Priority to SG11201807875XA priority patent/SG11201807875XA/en
Publication of WO2017164275A1 publication Critical patent/WO2017164275A1/fr

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor

Definitions

  • the present invention relates to a composition for improving the oral environment, and more particularly to a food composition for improving the oral environment.
  • the bodily sensation obtained with the above-described oral refreshing confectionery is due to a transient refreshing feeling caused by the ingredients that impart a refreshing sensation, and the bad breath cannot be fundamentally solved.
  • oral bacteria can be removed locally or temporarily using a conventional mouthwash containing a bactericidal component, there is a risk that oral bacteria may spread and settle from another site.
  • disrupting the stable bacterial flora with a bactericide may make it easier for pathogenic bacteria to settle (Non-patent Document 1).
  • An object of the present invention is to provide a novel composition for improving the oral environment.
  • the present inventors have promoted the growth of Bifidobacterium genus bacteria derived from human oral cavity by fermented propionic acid bacteria, and ingested tablets containing fermented propionic acid bacteria in the oral cavity. To actually promote the growth of Bifidobacteria, and also to reduce the bad breath and reduce the number of bad breath-causing bacteria by letting the subject take tablets containing fermented propionic acid bacteria I found.
  • the present invention is based on these findings.
  • a composition for improving the oral environment and an agent for improving the oral environment containing a fermented product of propionic acid bacteria as an active ingredient (hereinafter sometimes referred to as “the composition and the agent of the present invention”).
  • the composition and the agent of the present invention The composition and agent according to [1] above, wherein the propionic acid bacterium is Propionibacterium freudenreichii .
  • the fermented product is a whey fermented product.
  • composition and agent according to any one of [1] to [4] above, for suppressing bad breath [6] The composition and agent according to any one of [1] to [5] above, which is a food composition. [7] The composition and agent according to any one of [1] to [6] above, which are in the form of a tablet. [8] The composition and preparation according to any one of the above [1] to [7], which are in a packaging form suitable for once intake. [9] The composition and preparation according to any one of [1] to [8] above, which are in a packaging form suitable for multiple intakes. [10] Use of a fermentation product of propionic acid bacteria for the production of a composition for improving the oral environment or a composition for suppressing bad breath. [11] A method for improving oral environment and oral malodor control, comprising ingesting or administering an effective amount of a fermented propionic acid bacterium to a subject in need of oral environment improvement or bad breath suppression Method.
  • an oral environment improving composition and an oral environment improving agent containing a fermented product of propionic acid bacteria as an active ingredient.
  • the active ingredient of the composition and the preparation of the present invention is a fermented product of natural microorganisms conventionally used in the production of foods, and since the microorganism is used, the fermented product can be produced in large quantities. Therefore, it can be said that the composition and the preparation of the present invention are very attractive techniques from the viewpoint of safety and cost.
  • the composition and the agent of the present invention comprise a fermented product of propionic acid bacteria as an active ingredient.
  • the fermented product of propionic acid bacteria used in the present invention is a fermented product obtained by culturing propionic acid bacteria.
  • Nutrient sources of the medium used in the culture process include dairy products, yeast extract, soybean extract, and these enzymes. Examples include processed products.
  • the culture medium is preferably a medium containing a dairy proteolytic enzyme-treated product.
  • a medium containing a carbon source is preferred, and the carbon source in the present invention refers to a carbon source that can be assimilated by propionic acid bacteria.
  • Examples of carbon sources that can be assimilated by propionic acid bacteria include lactose, glucose, lactic acid, glycerol, gluten, and cellulose, and lactose is particularly preferable.
  • the carbon source content in the medium before the start of the culture is preferably 4 to 8% by mass, more preferably 4 to 7% by mass, and particularly preferably 4 to 6.7% by mass.
  • a medium containing lactose as a carbon source whey powder, casein, skim milk powder, whey protein concentrate in which whey is dialyzed to reduce lactose content, or lactose content is further purified. Examples include separated whey protein isolates.
  • protease can be used as they are or after being treated with protease, and can be used as a carbon source that can be assimilated by propionic acid bacteria such as peptone such as yeast extract and trypticase, and glucose, lactose and lactose-treated lactase.
  • propionic acid bacteria such as peptone such as yeast extract and trypticase
  • glucose lactose and lactose-treated lactase.
  • sugars such as saccharides and / or disaccharides, and minerals such as lactic acid, glycerol, gluten, cellulose, and whey minerals.
  • a culture medium can be prepared by adding.
  • Dairy products used as nutrient sources for culture media include raw milk, concentrated milk, whole milk powder, skim milk, skim milk powder, milk protein (MPC (milk protein concentrate)), casein, whey, concentrated whey, whey protein concentrate ( WPC), whey protein isolate (WPI), whey powder, and the like.
  • MPC milk protein concentrate
  • WPC milk protein concentrate
  • WPI whey protein isolate
  • whey powder and the like.
  • whey, concentrated whey, and whey protein concentrate are preferable.
  • whey fermented product of propionic acid bacteria using whey, concentrated whey or a proteolytic enzyme-treated product of whey protein concentrate as a nutrient source of the medium is referred to as “whey fermented product of propionic acid bacteria”.
  • Propionibacterium Propionibacterium
  • Propionibacterium SIMO eggplant Propionicimonas
  • Propionibacterium Fe LUX Propioniferax
  • Propionibacterium micro-bi um Propionimicrobium
  • propionyl Although there is a Vibrio ( Propionivibrio ) genus and the like, and not particularly limited, bacteria belonging to the genus Propionibacterium are preferable.
  • the bacteria of the genus Propionibacterium for example, Propionibacterium, Freudenberg Reich (Propionibacterium freudenreichii), Propionibacterium-Toeni (Propionibacterium thoenii), Propionibacterium-reed Diplomat Pio Western (Propionibacterium acidipropionici), professional Propionibacterium jensenii , Propionibacterium avidum , Propionibacterium acnes , Propionibacterium lymphophilum , Propionibacterium lymphophilum ( Propionibacterium lymphophilum ) And propionic acid bacteria such as Propionibacterium granulosam ).
  • Propionibacterium freudenreich is more preferable, and in particular, Propionibacterium freudenreich IFO12424, Propionibacterium freudenreich ATCC6207, Propionibacterium freudenreich ET-3 strain (FERM BP-8115) ) Is preferred.
  • the production of a fermentation product of propionic acid bacteria can be carried out, for example, as follows. -After inoculating the precultured propionic acid bacteria-containing culture solution into the culture solution (1 to 3 L), main culture is performed. -During the culture at 30 to 40 ° C, the culture solution is sparged with 0.1 to 1 L / min of nitrogen gas and anaerobically cultured at a stirring speed of 50 to 200 rpm for 140 to 160 hours. At this time, after culturing for 1 to 2 days after inoculation of propionic acid bacteria, a saccharide which is an arbitrary medium composition component may be continuously added at 0.5 to 20 mL / hour.
  • the fermented product of propionic acid bacteria which is an active ingredient of the present invention is obtained by culturing propionic acid bacteria, and includes both propionic acid bacteria and cultures.
  • the obtained fermentation product of propionic acid bacteria may be used as it is, but may be appropriately concentrated, diluted, dried or the like.
  • a fermented product of propionic acid bacteria is also produced according to a known production method described in International Publication No. 2003/016544, International Publication No. 2005/099725, International Publication No. 2009/107380, International Publication No. 2012/132913, or the like. You can also Alternatively, a commercial product containing a fermented product of propionic acid bacteria (for example, B.G.S.POWDER (manufactured by Meiji Co., Ltd.) may be used.
  • B.G.S.POWDER manufactured by Meiji Co., Ltd.
  • the composition and the agent of the present invention can be used alone or in a mixture with other components of the fermentation product of propionic acid bacteria.
  • the content of fermented propionic acid bacteria (solid content conversion standard) in the composition and preparation of the present invention is not particularly limited as long as the effect of improving the oral environment is exhibited, but it should be 10 to 100% by mass It is preferably 10 to 50% by mass, more preferably 10 to 20% by mass.
  • the preparation of the present invention may be a fermented product of propionic acid bacteria, and the composition of the present invention may be a fermented product of propionic acid bacteria and other components.
  • composition and agent of the present invention may contain a saccharide that can be assimilated by oral bifidobacteria in addition to the fermented propionic acid bacterium.
  • a saccharide that can be assimilated by oral bifidobacteria in addition to the fermented propionic acid bacterium.
  • select Bifidobacterium such as glucose, galactose, fructose, sucrose, maltose, melibiose, lactose and other monosaccharides and disaccharides, raffinose, lactulose, fructooligosaccharide, isomaltoligosaccharide, galactooligosaccharide, etc.
  • An example of an oligosaccharide that is allowed to proliferate is palatinose.
  • the content of saccharides that can be assimilated by oral bifidobacteria in the compositions and preparations of the present invention is not particularly limited as long as the effect of improving the oral environment is exhibited, but 0 to 80 mass. %, Preferably 0 to 60% by mass.
  • the composition of the present invention is used for improving the oral environment and can be used as an oral environment improving agent.
  • the improvement of the oral environment is used in the meaning including the improvement of the oral flora, for example, the reduction and / or proliferation of the total number of oral pathogenic bacteria such as bad breath-causing bacteria and periodontal disease-related bacteria. And the increase in the total number of so-called good bacteria such as oral bifidobacteria and / or promotion of proliferation.
  • the halitosis causing bacteria Fusobacterium genus bacteria such as Fusobacterium nucleatum (Fusobacterium nucleatum), etc.
  • Beironera bacteria such Beironera-disper (Veillonella dispar) and the like.
  • Periodontal disease-related bacteria include Porphyromonas gingivalis and other Porphyromonas bacteria, Prevotella intermedia , Prevotella nigrescens and other Prevotella bacteria, and Treponema.
  • -Denticola Treponema denticola
  • Tannella forsythensis Tannella forsythensis
  • Actinobacillus actinomycetemcomitans Actinobacillus actinomycetemcomitans ) etc.
  • Bifidobacteria in the oral cavity include Bifidobacterium dentium , Bifidobacterium adolescentis , Bifidobacterium longum , Bifidobacterium longum , Bifidobacterium urinalis ( Bifidobacterium urinalis ) and the like.
  • the total number of oral pathogens such as bad breath causing bacteria and periodontal disease-related bacteria can be reduced, or the growth can be suppressed.
  • Oral diseases such as diseases can be prevented or treated. That is, the composition and the agent of the present invention can be used for suppressing bad breath and can be used as a bad breath suppressant.
  • bad breath refers to what a person feels a bad breath component contained in exhaled breath, and is a general term for malodors emitted from the oral cavity together with exhaled breath.
  • Representative components of the malodor include volatile sulfur-containing compounds such as hydrogen sulfide and methyl mercaptan.
  • compositions and preparation of the present invention are not particularly limited as long as the effect of improving the oral environment is exhibited, and even in a solid form, a liquid, a semi-liquid, a gel, or a paste It may be in the form of powder.
  • the composition and agent of the present invention include food compositions such as tablets (for example, troches and chewable tablets), gums, gummies, candy, tablet confectionery, beverages, yogurt, jelly, edible films, and dentifrices.
  • Oral care compositions such as mouthwashes, mouthwashes, denture cleaners, orally disintegrating tablets, and gels, and tablets, gums, gummies, and candy are preferred from the viewpoints of portability and oral retention.
  • the composition and the agent of the present invention can contain other known additives as optional components in addition to the fermentation product of propionic acid bacteria.
  • composition and agent of the present invention when providing the composition and agent of the present invention as a tablet, in addition to the fermented product of propionic acid bacteria, carbohydrates, excipients, sweeteners, acidulants, fragrances, colorants, preservatives, stabilizers , One or more components selected from emulsifiers, plant extracts, fruit juice powders, and the like can be blended and produced by conventional methods.
  • the fermented product of propionic acid bacteria Since the fermented product of propionic acid bacteria has an excellent action for improving the oral environment, it can be provided in foods taken daily or foods taken as supplements. That is, the composition and agent of the present invention can be provided as a food composition.
  • the composition and the preparation of the present invention are usually used for the normal production of the food except that the fermented product of propionic acid bacteria as an active ingredient is blended. It can be manufactured according to the procedure.
  • the fermented product of propionic acid bacteria which is an active ingredient of the present invention can be prepared by containing the fermented product of propionic acid bacteria as it is in the food, and the food composition is propion. It is a food containing an effective amount of fermented acid bacteria.
  • “containing an effective amount” of a fermented product of propionic acid bacteria means that the fermented product of propionic acid bacteria is ingested within a predetermined range when an amount normally consumed in each food is ingested. Say quantity.
  • the composition and preparation of the present invention can be provided as a composition and preparation comprising a fermented product of propionic acid bacteria in a single intake effective for improving the oral environment.
  • the intake amount of the fermented propionic acid bacteria effective for improving the oral environment and the number of intakes per day can be determined depending on the age, symptoms, and body sensation of the user.
  • the intake amount of the fermented product of propionic acid bacteria effective for improving the oral environment is 100 mg to 1000 mg / time, preferably 100 mg to 300 mg / time, in terms of solid content.
  • the number of intakes of the fermented propionic acid bacteria per day effective for improving the oral environment is 1 to 10 times / day, preferably 1 to 5 times / day.
  • compositions and the preparation of the present invention are provided as a composition containing a fermented product of propionic acid bacteria for a single intake
  • the composition is in a unit package form so that the effective intake can be ingested. It is desirable to provide in.
  • a description relating to the intake amount is provided on the package so that an effective intake amount for one dose can be ingested, or a document including the description is provided together.
  • the composition and preparation of this invention can exhibit the improvement effect of the oral environment more excellent by taking continuously. For example, when the effective intake for one day is provided in a plurality of packages, a plurality of packages for the effective intake for one day can be provided as a set for convenience of intake.
  • the packaging form for providing the composition and the preparation of the present invention is not particularly limited as long as it defines a certain amount.
  • wrapping paper, packaging sheet, bag, soft bag, paper container, can, bottle Examples of containers that can be accommodated include capsules and plastic cases.
  • composition and the preparation of the present invention can be ingested by the user himself / herself by determining the amount of intake according to the experience. Therefore, the composition and the preparation of the present invention can be preferably provided in a form in which the intake can be adjusted according to the taste of the intake person, that is, in a form suitable for multiple intakes. Examples include tablets, powders, gums, gummi, and candy. Examples of packaging suitable for multiple intake include plastic cases, cans, bottles, and wrapping paper.
  • the composition and the preparation of the present invention can be provided as a plurality of tablets containing a plurality of doses (for example, 10 to 15 doses). A form that can be taken in a plurality (for example, about 1 to 10) is preferable.
  • a tablet with multiple doses (for example, 10 to 15 doses) can take any of the packaging forms as described above, and a plastic case is preferred from the viewpoint of convenience of storage and portability and ease of intake.
  • compositions and the preparation of the present invention are preferably ingested continuously for 3 days or more in order to exert their effects better, the administration and ingestion period is more preferably 1 to 2 weeks, particularly preferably 1 to 4 Week.
  • “continuously” means to continue taking a predetermined amount every day.
  • an effective intake for a certain period for example, one week may be provided as a set for continuous intake.
  • improvement of the oral environment comprising ingesting or administering an effective amount of a fermented propionic acid bacterium to a subject in need of improvement of the oral environment or suppression of bad breath
  • Methods and halitosis control methods are provided.
  • the method for improving the oral environment and the method for suppressing bad breath of the present invention can be carried out according to the description of the composition and the preparation of the present invention.
  • the subject of ingestion or administration is a mammal including a human, and is a human or non-human mammal.
  • a fermented propionic acid bacterium for the production of a composition for improving the oral environment or a halitosis suppression composition.
  • the present invention also provides the use of a fermented product of propionic acid bacteria for the production of an oral environment improving agent or a bad breath suppressant.
  • the present invention further provides a fermented product of propionic acid bacteria for use in improving the oral environment or suppressing bad breath.
  • a fermented product of propionic acid bacteria as an oral environment improving agent or a halitosis suppressant.
  • Example 1 Confirmation of growth promoting action of Bifidobacterium genus bacteria derived from human oral cavity by propionate bacteria whey fermentation product (1) Preparation of propionate bacteria whey fermentation product Implementation of International Publication No. 2012/132913 According to Example 1, a whey fermentation product of propionic acid bacteria was prepared. Specifically, the Propionibacterium flodenreich ET-3 strain (FERM BP-8115) was activated and precultured at 30 ° C. under anaerobic conditions for 48 hours, and further cultured at 30 ° C. under anaerobic conditions for 72 hours.
  • the Propionibacterium flodenreich ET-3 strain (FERM BP-8115) was activated and precultured at 30 ° C. under anaerobic conditions for 48 hours, and further cultured at 30 ° C. under anaerobic conditions for 72 hours.
  • the culture was centrifuged (centrifugation conditions: 8000 rpm, 4 ° C., 10 minutes), and the culture supernatant was collected and filter sterilized to obtain a culture supernatant.
  • the culture supernatant was used as a whey fermentation product of propionic acid bacteria. It has been confirmed that 1,4-dihydroxy-2-naphthoic acid (DHNA) is contained as a main active ingredient in the whey fermentation product of propionic acid bacteria.
  • DHNA 1,4-dihydroxy-2-naphthoic acid
  • Test method A fermented propionic acid bacterium was added to 5 mL of MN1 medium so that the DHNA would be 25 or 50 ng / mL, and various Bifidobacterium bacteria or controls derived from human oral cavity shown in Table 1 bacteria (Fusobacterium nucleatum (Fusobacterium nucleatum) and Porphyromonas gingivalis (Porphyromonas gingivalis)) were inoculated 10 ⁇ 30 [mu] L, and incubated at 37 ° C.. After culturing for 15 to 21 hours, the absorbance was measured using a spectrophotometer (manufactured by Beckman).
  • the MN1 medium is composed of trypticase peptone 2 g, phyton peptone 0.75 g, yeast extract 1.25 g, K 2 HPO 4 0.5 g, KH 2 PO 4 0.75 g, MgCl 2 .6H 2 O 0.125 g, L -0.125 g of cysteine / hydrochloride, 2.5 mg of FeSO 4 ⁇ 7H 2 O and 20 g of glucose were dissolved in 1000 mL of pure water, adjusted to pH 6.5 with hydrochloric acid or sodium hydroxide, and then autoclaved at 121 ° C for 15 minutes. It was prepared by doing.
  • the content of DHNA in the whey fermented product was measured under the following HPLC analysis conditions using a high-performance liquid chromatograph (HPLC-UV) analyzer equipped with an ultraviolet spectrophotometric detector.
  • HPLC-UV high-performance liquid chromatograph
  • Example 2 Ingestion test of whey fermented product of propionic acid bacteria (1) Test food A tablet containing a powder composed mainly of fermented whey of propionic acid bacteria was prepared according to a conventional method and used as a test food. . In the tablet, 95 mg of whey fermented product (prepared according to Example 1 (1)) per grain (500 mg) was blended in solid mass, and 308 mg of glucose was blended.
  • Bacteria test Saliva immediately after waking up was collected, and the number of Bifidobacterium bacteria in the saliva was counted by real-time PCR.
  • Example 3 Evaluation of oral environment improvement effect by ingestion of fermented product containing propionic acid bacterium
  • the effect of whey fermented product of propionic acid bacterium on oral environment was evaluated.
  • Test food A tablet containing a powder composed mainly of a whey fermentation product of propionic acid bacteria was prepared according to a conventional method and used as a test food.
  • the tablet contained 95 mg of whey fermented product (prepared according to Example 1 (1)) in terms of solid content per tablet (900 mg).
  • the bad breath was measured by measuring the concentration of a volatile sulfur compound (hydrogen sulfide, methyl mercaptan) that is a bad breath causing substance in oral gas using oral chroma (Abi Medical Co., Ltd.).
  • a volatile sulfur compound hydrogen sulfide, methyl mercaptan
  • Bacteria testing was performed by collecting saliva immediately after waking up and counting the number of Fusobacterium nucleatum, known as bad breath causing bacteria, by real-time PCR.
  • Fig. 3 shows the results of the bacterial test. From the results shown in FIG. 3, it was found that the number of Fusobacterium nucleatum in saliva (in the oral cavity) decreased by ingesting a tablet containing a whey fermented product of propionic acid bacteria for 4 weeks.

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Abstract

L'invention a pour objet de fournir une nouvelle composition pour amélioration de l'environnement de la cavité buccale. Plus précisément, l'invention fournit une composition pour amélioration de l'environnement de la cavité buccale qui contient en tant que principe actif un produit de fermentation de bactéries propioniques. La composition de l'invention peut servir de composition alimentaire. De préférence, les bactéries propioniques sont des Propionibacterium freudenreichii, et leur produit de fermentation est un produit de fermentation de lactoserum.
PCT/JP2017/011619 2016-03-24 2017-03-23 Composition pour amélioration de l'environnement de la cavité buccale WO2017164275A1 (fr)

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JP2018507389A JP7107835B2 (ja) 2016-03-24 2017-03-23 口腔内環境改善用組成物
CN201780018624.8A CN109152728B (zh) 2016-03-24 2017-03-23 口腔内环境改善用组合物
SG11201807875XA SG11201807875XA (en) 2016-03-24 2017-03-23 Composition for improving oral cavity environment

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