WO2017134837A1 - Nouvel agent pour la pousse des cheveux - Google Patents

Nouvel agent pour la pousse des cheveux Download PDF

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Publication number
WO2017134837A1
WO2017134837A1 PCT/JP2016/058617 JP2016058617W WO2017134837A1 WO 2017134837 A1 WO2017134837 A1 WO 2017134837A1 JP 2016058617 W JP2016058617 W JP 2016058617W WO 2017134837 A1 WO2017134837 A1 WO 2017134837A1
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Prior art keywords
hair
extract
hair growth
scientific name
head
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PCT/JP2016/058617
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English (en)
Japanese (ja)
Inventor
大 鮎澤
裕貴 高氏
健輔 三木
ナジール ホサイン モハマド
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イチバンライフ株式会社
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth

Definitions

  • the present invention relates to a hair growth agent characterized by combining a plurality of herbal extracts that promote the growth of cells involved in hair formation and synergistically enhancing the hair growth effect.
  • Ayurveda In treating intractable diseases or lifestyle-related diseases, the long-lived science “Ayurveda” of India 5,000 years is considered to be very useful. Ayurveda has tested a myriad of plant materials (hereinafter referred to as herbs) and combined them to address disease treatment and healthy longevity. The herbs used by Ayurveda have been supported by numerous clinical trials and provide a treasure trove of bioactive substances. Herbal materials exhibiting hair growth or hair growth effects are also known (Non-Patent Documents 1 to 5), and hair products combining herbs are also commercially available. Further, scientific verification has already begun on herb materials having physiological effects such as hair growth, including research by the inventors (Patent Documents 1 to 12). However, the most important combination of herbs that Ayurveda places most emphasis on has not been scientifically verified due to the difficulty of the experimental design and the scale of the experiment.
  • Ayurveda uses three life principles (Vata, Pitta, Kapa) to capture life phenomena and diagnose and treat diseases.
  • three life principles are utilized.
  • a combination of three herb ingredients creates many effective drugs such as healthy longevity recipes. Even if each herb is not effective, the combination of the three types can produce an excellent effect.
  • the present invention employs this rule, and based on the combination of three kinds of herbs, can create a composition for the head having a sufficient hair growth effect.
  • JP-A-2011-157319 Melanin production inhibitor JP 2010-222273 Hair nourishing composition JP 2010-159213 A Antioxidant JP 2010-150176 A skin external preparation JP 2010-1000055 A Melanin production inhibitor JP2010-047497 Elastin production promoter JP 2009-227598 A Reactive oxygen species cell disorder inhibitor or recovery agent JP2009-184997 Collagen production promoter JP 2008-184441 A skin external preparation for promoting cell growth JP 2008-184440 A skin external preparation for improving UV cell damage JP 2008-184439 A skin external preparation for improving reactive oxygen species cell damage JP-A-2008-143784 Cell growth promoter
  • the inventor has conducted various physiological tests on many traditional herbs widely used by Ayurveda from the viewpoint of promoting cosmetic health. Using extracts of herbs that are said to have hair growth effects, we have examined the effects of promoting growth and stress resistance on hair matrix cells, dermal papilla cells, epidermal keratinocytes, and dermal fibroblasts involved in hair formation. It was. Some herbs showed significant growth promoting effects in these cell types. Some of these results are described in Patent Documents 1 to 12. In addition, even when these herbs were combined, a slight synergistic effect was observed in the proliferation test using a single cell type. Hair formation is a joint work of the above cell types, and hair growth tests using living bodies are inevitable.
  • a composition for the head (hereinafter referred to as a hair growth agent) characterized by containing all the extracts of Amura (scientific name: Emblica officinals), anemonefish (scientific name: Wedelia calendulacea), Takasaburo (scientific name: Eclipta alba) as active ingredients.
  • the hair growth agent having a remarkable hair growth effect is provided.
  • the cosmetic method characterized by applying this hair growth agent to a scalp is provided.
  • At least one extract in addition to the mixture of herbal extracts, at least one extract, more preferably all of the extracts of the first box (Centella asiatica), Indian pine (Scientific name: Plumbago zeylica), and chiletta assembly (scientific name: Swertia chirata)
  • the hair growth agent which has the further remarkable hair growth effect is provided.
  • extracts from Yugao (scientific name: Lagenaria siceraria) and aloe vera (scientific name: Aloe vera) may be blended simultaneously.
  • nucleic acids, amino acids or vitamins may be added at the same time.
  • Hair growth agents provided by the present invention include herbs that activate hair follicles and scalp cells. It also contains wastes that cause scalp aging and herbs that promote the excretion of toxins. By continuously applying to the scalp, it exhibits hair loss prevention, hair growth effect, and hair growth effect regardless of age and sex, and without side effects.
  • the hair growth agent of the present invention contains all the extracts of three herbs (Amla, Takasaburo, Anemone) as active ingredients.
  • the hair growth agent of the present invention contains at least one of three herbs (composite, Indian pine, chillet assembly), more preferably all extracts as active ingredients.
  • the hair growth agent of the present invention comprises at least one of 10 kinds of herbs (Bernoki, Togebarelia, Atlantic cedar, Ceylon Nikkei, Licorice, Bussouge, Yorsokei, water lily, sandalwood, Seitakami balun), more preferably all active ingredients. Include as. Preferably, all of these ten kinds of extracts are included.
  • the hair growth agent of this invention it is desirable to mix
  • nucleic acids refer to purine or pyrimidine deoxyribose or ribose, or derivatives thereof.
  • the nucleic acids may be blended alone, but it is desirable to blend a mixture thereof.
  • a mixture of thymidine, deoxyadenosine, deoxyguanosine, and deoxycytidine may be used, or a mixture of uridine, adenosine, guanosine, and cytidine.
  • it may be a mixture of thymine, adenine, guanine, and cytosino, and an extract of an organism such as yeast may be used as a source of nucleic acids.
  • amino acids as nutrients at the same time in addition to the mixture of herbal extracts described above.
  • the amino acids may be, for example, a mixture of 20 kinds of amino acids or their derivatives, or a part thereof.
  • the hair growth agent of the present invention is formulated with vitamins as nutrients in addition to the above herbal extract mixture.
  • Vitamins refer to 13 types of vitamin A, B 1 , B 2 , B 6 , B 12 , C, D, E, K, folic acid, niacin, biotin, pantothenic acid or derivatives thereof. A mixture of these or a part of the mixture may be used. Moreover, you may use the extract of yeast or a plant for a supply source.
  • the herb is a useful plant (fruit, leaf, stem, stem, bark, seedling, flower, fruit, seed, root, etc.) collected from the Indian subcontinent, the Middle East, Southeast Asia, etc. Or a mixture of multiple parts or whole plant).
  • the production area of the above-mentioned plant characterizing the present invention is not particularly limited. Any of them can be used as a plant body leaf, stem, stem, bark, bud, flower, fruit, seed, root, etc. or a mixture of a plurality of sites or extracted from the whole plant. In the present invention, sites recommended by Ayurveda (described in Table 1) were used.
  • each part When obtaining an extract from a plant, each part may be used as it is, but after appropriately performing pretreatment such as drying, shredding, crushing, pressing or fermentation, a solvent is used at low or warm temperature.
  • a solvent is used at low or warm temperature.
  • the extraction method is not particularly limited, and examples thereof include a method of immersing one part or two or more parts of the plant in a solvent at low temperature or room temperature to warming.
  • the extraction time is set according to the type of extraction solvent and the extraction temperature, but is preferably about 1 to 2 weeks.
  • the extraction solvent examples include water, lower monohydric alcohols (methyl alcohol, ethyl alcohol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, etc.), liquid polyhydric alcohols (glycerin, propylene glycol, dipropylene glycol).
  • 1,3-butylene glycol etc. 1,3-butylene glycol etc.
  • lower esters ethyl acetate, butyl acetate etc.
  • hydrocarbons benzene, hexane, pentane etc.
  • ketones acetone, methyl ethyl ketone etc.
  • ethers diethyl ether, tetrahydrofuran, di Propyl ether, etc.
  • acetonitrile and the like and one or more of them can be used.
  • vegetable oil sesame oil, coconut oil, olive oil, etc.
  • physiological saline phosphate buffer, phosphate buffered saline, etc.
  • physiological saline phosphate buffer, phosphate buffered saline, etc.
  • purification treatment such as deodorization and decolorization may be performed within a range not impairing the effects of the present invention.
  • an antiseptic / antifungal agent phenoxyethanol, p-hydroxybenzoates, etc.
  • filtration at a low temperature for 1-2 days, followed by filtration.
  • extraction was performed for 1 to 10 days by using water-containing ethyl alcohol or 1,3-butylene glycol having a concentration of 0 to 100% by volume at room temperature or warming.
  • the method of filtering later is mentioned.
  • the dry solid content is preferably 0.000001 to 10% by mass, more preferably 0.00001 to 3%. % By mass.
  • the hair growth agent of the present invention is preferably applied to the scalp and used in combination with a cosmetic method such as massage if necessary.
  • a cosmetic method such as massage if necessary.
  • the dosage of the hair growth agent of the present invention is too small, the effect of the invention cannot be obtained, and if it is too large, side effects may occur. It is preferably 0.0002 to 1340 ⁇ g / square centimeter / day, more preferably 0.0002 to 270 ⁇ g / square centimeter / day, per scalp unit area (1 square centimeter) in terms of dry solid content of the plant extract.
  • the hair growth agent of the present invention is selected from various commonly used medicinal ingredients, for example, other hair growth and hair nourishing agents, moisturizers, anti-inflammatory agents, antioxidants, cell activators, UV protection agents, blood circulation promoters and the like. It can be used in combination with one or more medicinal agents. Thereby, the effect of the present invention can be further enhanced.
  • hair growth agent of the present invention for example, as a hair growth assisting ingredient, for example, assembly extract, garlic extract, cephalanthin, ⁇ -oryzanol, carpronium chloride, acetylcholine, capsicum tincture, cantalis tincture, ginger tincture, nonyl acid vanillamide, salicylic acid Resorcinol, lactic acid, placenta extract, pentadecanoic acid glyceride, hinokitiol, allantoin, glycyrrhizic acid, glycyrrhetinic acid, isopropylmethylphenol, triclosan, zinc pyrithione, hinokitiol, menthol, camphor, photosensitizer 301, Cordyceps extract, trans-3, 4, -Dimethyl-3-hydroxyflavanone, Western Hypericum extract, Dutch mustard extract, Clara extract, Wheat germ extract, Salamander extract, Other women Rumon like, it may also
  • a moisturizing agent for example, alginic acid, sodium alginate, xylitol, glucose, polyethylene glycol, propylene glycol, dipropylene glycol, glycerin, polyglycerin, 1,3-butylene glycol, 1,2 -Pentanediol, hexylene glycol, xylitol, sorbitol, POE methyl glucoside, maltitol, maltose, mannitol, lysine, honey, royal jelly, chondroitin sulfate, sodium chondroitin sulfate, hyaluronic acid, sodium hyaluronate, sodium acetyl hyaluronate, mucoitin sulfate , Caronic acid, tranexamic acid, betaine, trehalose, chitosan, urea, ceramide, atelocollagen, chol
  • hair growth agent of the present invention for example, aminocaproic acid, allantoin, indomethacin, bisabolol, saponin, lysothium chloride, azulene, guaiazulene, guaiazulene sulfonate, glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its Derivatives, salicylic acid and derivatives thereof, hinokitiol, photosensitizer, tranexamic acid and derivatives thereof, zinc oxide, turmeric extract, ganoderm extract, button extract, litchi extract, bitumen extract and the like can be added.
  • an antioxidant for example, astaxanthin, ⁇ -carotene, ⁇ -oryzanol, kinetin, tocopherol, dibutylhydroxytoluene, flavonoid, SOD, catalase, fullerene, phytic acid, ferulic acid, chlorogen Acid, propyl gallate, green tea extract, rosemary extract, rosehip extract, ginger extract, horsetail extract, hamamelis extract, parsley extract, loquat leaf extract, grapefruit extract, citrus extract, lychee
  • An extract, mugwort extract, peach leaf extract, mango extract, button pi extract, pine bark extract, platinum, ubiquinone, ⁇ -lipoic acid and the like can be added.
  • aminobutyric acid for example, aminobutyric acid, ginkgo biloba extract, fennel extract, Dutch mustard extract, carrot extract, clara extract, chlorella extract, saffron extract, soybean An extract, a sesame extract, a photosensitizer, etc. can also be added.
  • a blood circulation promoter for example, a salamander extract, a pepper extract, a senkyu extract, a chimpan extract, a red pepper extract, a red pepper extract, a button extract, a nonyl acid wallenyl amide Nicotinic acid benzyl ester, nicotinic acid ⁇ -butoxyethyl ester, capsaicin, cantalis tincture, ictamol, caffeine, tannic acid, ⁇ -borneol, nicotinic tocopherol, inositol hexanicotinate, acetylcholine, cephalanthin, ⁇ -oryzanol, etc. Can be added.
  • a salamander extract for example, a salamander extract, a pepper extract, a senkyu extract, a chimpan extract, a red pepper extract, a red pepper extract, a button extract, a nonyl acid wallenyl amide Nicotinic
  • the hair growth agent of the present invention in addition to the above components, water, fats and oils, waxes, hydrocarbons, fatty acids, which are components usually used for external preparations, within a range not impairing the effects of the present invention, Higher alcohols, esters, plant extracts, vitamins, water-soluble polymers, surfactants, metal soaps, alcohols, polyhydric alcohols, pH adjusters, preservatives, fragrances, powders, thickeners, pigments , Chelating agents, and the like can be appropriately blended.
  • the dosage form of the hair growth agent of the present invention is not particularly limited, and examples thereof include low viscosity liquids, pastes, creams, foams, emulsions, packs, ointments, powders, aerosols, patches and the like.
  • the present invention can be applied to any of cosmetics, quasi drugs, and pharmaceuticals. Specifically, for example, hair growth and nourishing agents, hair art, hair liquid, head lotion, head emulsion, head cream, head mousse, eyebrow serum, eyelash serum, shampoo, rinse It can be applied to hair treatment etc.
  • mice Three types of samples indicated by symbols (16 herb mixed extract, 16 herb oil extract, 16 herb mixed extract supplemented with supplementary ingredients) were applied daily to the left and right of the back of 5 mice each. Some of the mice photographed after 7 weeks are shown. It is a figure which shows the result of applying about 1-2 mL of oil extract of 16 kinds of herbs twice in the morning and evening for 12 male monitors. Table 5 shows the observation results of the five monitors indicated. It is a figure which shows the result of having applied about 1 to 2 mL to the scalp twice about two types of samples (recipe A & B of Table 6) twice a day about 17 male monitors. Table 7 shows the observation results of the seven monitors designated.
  • Table 7 shows the observation results of the five monitors indicated.
  • [Table 1] A table showing the site of use of herbs used in the present invention and known physiological effects.
  • [Table 2] A table summarizing the results of cell tests using herbal extracts.
  • [Table 3] Composition table of samples used for mouse hair growth test.
  • [Table 4] The results of hair growth tests using mice are summarized.
  • [Table 5] A table summarizing the results of a human monitor test using hair oil.
  • Table 7 A table summarizing the results of a human monitor test using hair art.
  • the cell test, mouse animal test, and human monitor test that are the basis of the present invention will be described with reference to examples.
  • the cell test there are four cell types: hair matrix that synthesizes hair, hair papilla cells that control the hair cycle of hair matrix cells, epidermal keratinocytes that support hair follicles, and dermal fibroblasts that support hair follicles and epidermis It was used. It has been proved by medical research and the like that the mouse test can test many samples in a relatively short time and at the same time can be used as a substitute for a human model. A human monitor was used for the final evaluation of the hair growth agent. In addition, this invention is not restrict
  • a collagen-coated dish (60 mm) is seeded with 1 ⁇ 10 4 hair matrix cells (purchased from Toyobo), and FBS (5%), MSC growth supplement (1%) in Mesenchymal Stem Cell Medium (ScienCell Research Laboratories).
  • FBS 5%
  • MSC growth supplement (1%) in Mesenchymal Stem Cell Medium (ScienCell Research Laboratories).
  • the plant extract diluted 1000 to 100,000 times the day after sowing was added to the medium in an amount of 1% by volume.
  • 50% ethanol was added to the medium in an amount of 1% volume.
  • the medium was changed every 4 days, and the same amount of plant extract or 50% ethanol was added each time.
  • the proliferation effect was determined by counting the number of cells on the 14th day.
  • the results of cell proliferation rate are shown in Table 2 according to
  • a dish (60 mm petri dish) coated with poly-L-lysine was seeded with 1 ⁇ 10 4 papilla cells (purchased from Toyobo), and Papilla Cell Growth Medium (Toyobo) was FCS (1%), ITT (0. 5%), BPE (1%), and Cyp (0.5%) were used in the same manner as above.
  • the plant extract diluted 1000 to 100,000 times the day after sowing was added to the medium so as to be 1% by volume.
  • 50% ethanol was added to the medium in an amount of 1% by mass.
  • the medium was changed every 4 days, and the same amount of plant extract or 50% ethanol was added each time.
  • the proliferation effect was determined by counting the number of cells on the 14th day.
  • the results of cell proliferation rate are shown in Table 2 according to the following evaluation criteria.
  • Epidermal keratinocytes Each plant extract prepared as described above was evaluated for its growth promoting effect on epidermal keratinocytes as described below.
  • mice As a mouse hair growth test experimental animal, a 6-week-old BDF-1 male mouse in the rest period of the hair cycle was purchased. Mice enter the regression phase of the hair cycle at 6 weeks and enter the resting phase from 7 weeks. After acclimatization for one week, the back of the mouse was shaved with a clipper and a shaver, and samples were applied to the back once or twice a day. Five mice were used for each sample. In order to avoid the influence of individual differences, the two samples to be compared were applied to the left and right of the back of the same mouse. Observation and photographing were performed every week, and after 6 to 7 weeks, the hair growth effect was determined according to the following evaluation criteria.
  • the preparation method of the herb 16 type oil sample used for said Example is described. 16 kinds of herb powder were put into heated sesame oil and heated on low heat for 5-10 minutes. After cooling, a transparent oil fraction was collected by filtration and used as an oil extraction sample. This sample was used for the mouse test described above and the human monitor test described below.
  • Score 1 No change in skin color in test area
  • Score 2 Skin color in test area changed to black / gray (pre-stage of hair growth)
  • Score 3 hair began to grow in the form of dots in the test area
  • Score 4 hair grew densely in 1/3 to 1/2 of the test area
  • Score 5 hair grew almost over the entire test area
  • the combination of herbs used in the present invention was born from the inventor's many years of basic research on herbs.
  • the hair growth effect of the present invention far surpasses existing similar products, and the superiority, novelty, and usefulness in the medical or cosmetic field are clear.
  • the greatest feature of the present invention is that it is effective for both men and women and has no side effects. These features are specific to the present invention only. This is because cytotoxicity tests are conducted on all components, and safe components and added amounts are employed. From the above, the present invention is a gospel for many people who suffer from hair loss.

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Abstract

Les inventeurs ont utilisé des substances d'origine végétale dont des effets sur la pousse des cheveux avaient été suggérés, et ont testé leurs effets de promotion de la croissance sur quatre types de cellules impliquées dans la formation du cheveu. Le résultat a été la découverte de plusieurs substances d'origine végétale dont le potentiel à stimuler la croissance des cellules est prometteur. Une combinaison d'extraits de ces substances a démontré des effets remarquables sur la pousse de nouveaux poils dans des tests portant sur la pousse de nouveaux poils chez la souris. Dans des tests d'observation chez l'homme, il a été montré des effets significatifs de pousse de nouveaux cheveux, indépendamment de l'âge ou du sexe, et sans aucun effet indésirable. Ces caractéristiques ne sont pas observées avec les produits conventionnels de soin des cheveux, et de ce fait la présente invention comprenant une nouvelle combinaison d'extraits de plantes répond de façon suffisante aux critères de nouveauté et d'activité inventive. Le problème que cherche à résoudre l'invention est lié à l'intérêt croissant, d'apparition récente, porté aux produits cosmétiques pour le cuir chevelu, qui a conduit à des tentatives variées visant à fournir un agent pour la pousse de nouveaux cheveux. Cependant, aucun des produits conventionnels n'a atteint un niveau satisfaisant. La raison en est que les causes de la perte des cheveux et les mécanismes de la pousse de nouveaux cheveux sont très compliqués et ne peuvent pas être abordés par des idées simplistes. La cause principale de la perte des cheveux est le vieillissement du cuir chevelu et des follicules pileux. Il existe de ce fait une demande pour le développement d'un agent pour la pousse de nouveaux cheveux qui prenne en considération la régénération du cuir chevelu et des follicules pileux. La solution proposée par l'invention s'appuie sur l'"Ayurveda", une science originaire de l'Inde vieille de 5 000 ans qui utilise souvent des formulations à base de plantes et constitue de ce fait une malle aux trésors de substances physiologiquement actives. Plusieurs centaines de végétaux considérés comme présentant des effets de stimulation de la pousse des cheveux ont été sélectionnés à partir de cette malle aux trésors, et leurs effets sur la croissance de quatre types de cellules qui constituent les follicules pileux et le cuir chevelu ont été examinés. Le résultat a été la découverte de substances d'origine végétale qui favorisent la croissance de chacun de ces types de cellules. Des combinaisons de ces extraits ont été soumises à des essais systématiques étudiant la pousse de nouveaux poils chez la souris. Le résultat a été la découverte d'une combinaison de substances d'origine végétale possédant un effet remarquable sur la pousse de nouveaux cheveux. Cette combinaison a montré des effets remarquables, non observés jusqu'à présent, sur la pousse de nouveaux cheveux dans des tests d'observation chez l'homme auxquels participaient des hommes et des femmes, jeunes et vieux. Les effets de cette combinaison d'extraits de plantes ont été d'activer de manière synergique les différents types de cellules qui constituent les follicules capillaires et le cuir chevelu, et cette combinaison a montré des effets marqués, indépendents de l'âge et du sexe, de prévention de la chute des cheveux, de pousse des cheveux et de pousse de nouveaux cheveux, cela en un court laps de temps (3 à 6 mois). De plus, des substances naturelles ont été utilisées, et aucun effet indésirable d'aucune sorte n'a été observé. Considérant ce qui précède, la présente invention peut représenter une bénédiction pour la plupart des hommes et des femmes, jeunes et vieux, qui souffrent de cheveux clairsemés ou de perte des cheveux.
PCT/JP2016/058617 2016-02-03 2016-03-08 Nouvel agent pour la pousse des cheveux WO2017134837A1 (fr)

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CN108671092A (zh) * 2018-06-11 2018-10-19 杨松林 一种生发护发的中药及其制备方法
US11185492B2 (en) 2018-12-14 2021-11-30 Mary Kay Inc. Cosmetic compositions
CN115466713A (zh) * 2022-09-30 2022-12-13 北京熙朵医疗美容门诊部有限公司 一种用于cht活细胞植发技术的毛囊活化液及其制备方法
JP7585436B1 (ja) 2023-11-14 2024-11-18 株式会社 資生堂 メラニンの産生を抑制するための、アムラおよびハイビスカスの組み合わせ

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WO2021113885A1 (fr) * 2019-12-04 2021-06-10 Sunstar Joint Stock Company Préparations de produit de coloration capillaire à base d'herbes
KR102360708B1 (ko) * 2021-07-08 2022-02-14 (주)와이제이비앤 탈모 예방 및 모발 성장 촉진용 조성물

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US11883524B2 (en) 2018-12-14 2024-01-30 Mary Kay Inc. Cosmetic compositions
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JP7585436B1 (ja) 2023-11-14 2024-11-18 株式会社 資生堂 メラニンの産生を抑制するための、アムラおよびハイビスカスの組み合わせ
JP7585435B1 (ja) 2023-11-14 2024-11-18 株式会社 資生堂 メラニンの産生を抑制するための、リンゴンベリーおよびハイビスカスの組み合わせ

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