WO2015190541A1 - ステント - Google Patents
ステント Download PDFInfo
- Publication number
- WO2015190541A1 WO2015190541A1 PCT/JP2015/066805 JP2015066805W WO2015190541A1 WO 2015190541 A1 WO2015190541 A1 WO 2015190541A1 JP 2015066805 W JP2015066805 W JP 2015066805W WO 2015190541 A1 WO2015190541 A1 WO 2015190541A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- stent
- communication hole
- diameter
- holes
- tubular film
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
- A61F2002/072—Encapsulated stents, e.g. wire or whole stent embedded in lining
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0014—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0017—Angular shapes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0017—Angular shapes
- A61F2230/0019—Angular shapes rectangular
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0004—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof adjustable
- A61F2250/001—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof adjustable for adjusting a diameter
Definitions
- the present invention relates to a stent including a stent body capable of expanding the diameter and a tubular film held on the stent body.
- a tubular intraluminal graft called a stent is carried to the stenosis site through the inside of the blood vessel and the diameter of the stent is expanded so that the stenosis site is expanded from the inside. May be treated with support.
- various operations such as aneurysm occlusion in which a stent is implanted at the site where an aneurysm has occurred and the aneurysm is occluded against the blood vessel are treated. The use of stents is being studied.
- Patent Document 1 discloses that the entire surface of a tubular metal stent body that can be expanded is covered with a flexible polymer film, thereby preventing metal allergy and the like, and smoothing the inner surface of the stent to disturb blood flow. Discloses a stent that suppresses the occurrence of thrombus. Furthermore, in the stent of Patent Document 1, by forming a plurality of micropores in the polymer film, endothelial cells are invaded through the micropores to promote endothelialization inside the stent, and a stent as a foreign substance is transplanted into a blood vessel. This prevents thrombus generation and intimal thickening.
- a stent in which holes are formed in a film that covers the stent body is set to an appropriate value for the opening ratio (hole area per unit area of the film), whereby endothelial cells to the inside of the stent are set.
- the film around the hole can be used as a scaffold for promoting endothelialization inside the stent.
- the aperture ratio when using a stent for the treatment of an aneurysm, by setting the aperture ratio to an appropriate value, it is possible to sufficiently block the blood flowing from the blood vessel into the aneurysm, and the stent. Even when the blood vessel is branched from the site where the graft is implanted, it is possible to prevent the branched blood vessel from being completely blocked by the stent.
- JP 2004-261567 (Claims 1, 2, 5, paragraphs 0012, 0017, 0024 to 0027)
- the film between the holes can have a wide portion and a narrow portion.
- Cheap endothelization inside the stent may be delayed because the endothelial cells such as blood vessels are less likely to penetrate into the part of the wide part of the film that is away from the peripheral edge of the hole, and the stent is implanted into the blood vessel.
- the wide film portion between the holes is located at the branch portion of the blood vessel, so that the stent film may block the branch blood vessel.
- An object of the present invention is to provide a stent that can obtain sufficient strength while easily endothelizing the inside of the stent and that can prevent occlusion of a branch vessel.
- a stent according to the present invention comprises a stent body capable of expanding the diameter and a tubular film held by the stent body, and a plurality of the tubular films communicated inside and outside. And a band-shaped portion having a constant width in the expanded diameter state of the stent body is formed between the adjacent communication holes.
- the band-shaped part between the communication holes in the tubular film is formed in a constant width in a diameter-enlarged state, the strength of a part of the band-shaped part is not generated because a wide part and a narrow part are not generated.
- the width of the belt-like portion can be suppressed as a whole, and the formation of a wide portion can be prevented.
- part away from the periphery of a hole can be reduced, an endothelial cell can be easily penetrate
- the stent is not limited as long as the band-shaped portion of the tubular film has a certain width in the expanded state of the stent body, and even if the stent body is forcibly inflated with a balloon, It may be formed of a shape memory alloy so as to be self-expanding.
- the stent should be used in various luminal parts of the human body such as cerebral artery, coronary artery, bile duct, esophagus, trachea, prostate, ureter, fallopian tube, aorta, peripheral artery, renal artery, carotid artery, cerebral blood vessel, etc. In particular, by using an ultrafine stent, it can be used for treatment in the field of brain surgery.
- the stent may be one in which the communication hole is set in a hexagonal shape in the expanded state of the stent body.
- the film around the communication holes can be configured in a honeycomb structure, and sufficient strength can be obtained while increasing the aperture ratio of the tubular film to a desired value. be able to.
- the stent may be one in which the communication hole is set to a diamond shape in the expanded state of the stent body.
- the communication hole is set to a rhombus, when expanding the diameter of the stent body, the peripheral part of the communication hole can be deformed like a pantograph and can follow the deformation of the stent body.
- the communication hole is not limited to a hexagon or a rhombus, and may be any shape such as a quadrilateral other than a rhombus, a triangle, or an arc, as long as it can form a band-shaped portion having a constant width therebetween. Also good.
- the present invention also includes a stent body capable of expanding the diameter and a tubular film held by the stent body, and a plurality of communication holes communicating with the inside and outside of the tubular film are arranged in a plurality of rows in the stent circumferential direction.
- the plurality of rows of communication holes are formed by alternately shifting the positions in the stent circumferential direction, and the rows of communication holes adjacent to each other are formed by overlapping the ends in the stent central axis direction in the stent circumferential direction.
- a stent is provided.
- the peripheral portion of the communication hole is obtained by expanding the stent body and forcibly stretching the tubular film in the stent circumferential direction.
- the central portion excluding the end portion can be applied with a pulling force in the circumferential direction of the stent.
- the portion of the peripheral edge of the communication hole that intersects the stent peripheral direction can be deformed into a mountain shape, and the peripheral edges of the communication holes adjacent to each other can be deformed substantially in parallel.
- the belt-like portion between the communication holes can be formed with a constant width.
- the communication hole may be any one in which the peripheral edge of the communication hole is deformed into a mountain shape when the tubular film is stretched in the stent circumferential direction, and therefore, “a plurality of communication holes are arranged in the stent circumferential direction and in a plurality of rows”.
- the term “communication holes” does not necessarily mean that the communication holes are accurately arranged in the circumferential direction of the stent, and it is a concept including that the communication holes are arranged to be inclined with respect to the circumferential direction of the stent.
- the communication holes can be formed in various shapes, for example, a rectangular shape in which a pair of opposite sides are parallel to the stent central axis direction before the stent body is expanded.
- the communication holes before diameter expansion are rectangular, and the pair of opposite sides are set parallel to the stent central axis direction, so by expanding the diameter of the stent body, the pair of opposite sides are deformed into a mountain shape.
- the rectangular communication hole can be deformed into a hexagon, and the expanded tubular film can be formed into a honeycomb structure.
- the communication hole after diameter-expansion can also be comprised in a rhombus by setting the length of a side (remaining opposite side) sufficiently short with respect to the pair of opposite sides of a rectangle.
- the communication holes may be set in a hexagonal shape in which the pair of opposite sides are parallel to the stent central axis direction in a state before the diameter expansion of the stent body.
- the communication holes before diameter expansion are rectangular, and the pair of opposite sides are set parallel to the stent central axis direction, so by expanding the diameter of the stent body, the pair of opposite sides are deformed into a mountain shape.
- the hexagonal communication hole can be transformed into a rhombus.
- the communication hole may be set to an ellipse whose major axis is parallel to the stent central axis direction before the stent body is expanded.
- the communication hole before diameter expansion is set to an elliptical shape whose major axis is parallel to the stent central axis direction, so that by expanding the diameter of the stent body, a pair of sandwiching the major axis of the peripheral edge of the communication hole
- the elliptical communication hole can be deformed into a diamond shape by deforming the portion of the above.
- the plurality of communication holes need not all have the same shape, and a combination of communication holes having different shapes such as a rectangle and a square, or a combination of communication holes having different sizes may be employed.
- a plurality of communication holes are formed in the tubular film held by the stent body, and the band-like portions between the communication holes adjacent to each other are set to have a constant width in an expanded state. Yes.
- the band-shaped portion it is possible to prevent the band-shaped portion from forming a wide portion, so that endothelial cells can be easily infiltrated by infiltrating endothelial cells almost entirely inside the stent, and a decrease in the strength of part of the band-shaped portion can be prevented. Sufficient strength can be obtained, and the occlusion of the branch blood vessel by the wide portion can be prevented.
- the stent 1 is used for treating a stenosis site in a lumen such as a blood vessel by expanding it from the inside, or for treating a blood vessel by occluding an aneurysm.
- a stent body 2 that can be expanded and a tubular film 3 held by the stent body 2, and a plurality of communication holes 4 that communicate with the inside and outside of the tubular film 3 are arranged in a plurality of rows in the circumferential direction of the stent.
- a plurality of rows of communication holes 4 are formed by alternately shifting the positions in the stent circumferential direction, and the communication holes 4 in rows adjacent to each other are overlapped with each other in the stent central axis direction in the stent circumferential direction. Is formed.
- the stent body 2 is, for example, made of a metal having a tubular shape and having a mesh-like structure that can be expanded flexibly.
- the diameter of the stent body 2 is about 10 to 100 mm before diameter expansion, and the diameter is 1/10 to 1/10 of the length.
- the diameter is set to about 1/2 and the thickness is set to about 30 to 500 ⁇ m, and the diameter is expanded to about twice the diameter before the expansion.
- the metal constituting the stent body 2 include biocompatible stainless steel, titanium, tantalum, aluminum, tungsten, nickel / titanium alloy, cobalt / chromium / nickel / iron alloy, and the like.
- the stent body 2 may have a self-expandable shape that has been heat-treated and shape-memorized, or may be forcibly expanded by a balloon.
- the tubular film 3 is made of, for example, a highly flexible polymer elastomer, and has a film thickness and a covering portion thickness of 5 ⁇ m to 100 ⁇ m and covers the entire surface of the stent body 2.
- the polymer elastomer include segmented polyurethane, polyolefin-based polymer, and silicone-based polymer.
- the segmented polyurethane polymer has excellent antithrombotic properties and excellent properties such as strength and elongation. This is preferable because it can follow the expanded diameter without breaking.
- the tubular film 3 does not necessarily have to cover the entire surface of the stent body 2, and may be, for example, a film simply wound around the stent body 2.
- the communication hole 4 has a pair of opposite sides 5 in parallel with the stent central axis direction (left and right direction in FIG. 3) in a state before the diameter expansion of the stent body 2.
- 6 is set to a horizontally long rectangle parallel to the circumferential direction of the stent (vertical direction in FIG. 3).
- the shape and arrangement of the communication holes 4 before the stent diameter expansion will be described using the symbols shown in FIG.
- the length of the side 6 as the height (Sh) of the communication hole 4 in the stent circumferential direction is 1.0, and other dimensions are shown as a ratio, the width (Sw) of the communication hole 4 in the stent central axis direction is shown.
- the length of the opposite side 5 is 3.3, the pitch (Ph) in the stent circumferential direction of the communication hole 4 is 4.3, the pitch (Pw) in the stent central axis direction of the communication hole 4 is 4.5, and the communication hole 4
- the width (Mh) of the upper and lower belt-like portions 7 is 1.2
- the width (Mw) of the left and right belt-like portions 8 of the communication hole 4 is 1.2.
- the height (Sh) of the communication hole 4 in the stent circumferential direction is, for example, about 30 ⁇ m.
- the balloon is expanded by applying hydraulic pressure, and the diameter of the stent 1 is expanded from about 3 mm to about 5 mm in diameter, as shown in FIGS. 6 remains unchanged, the pair of opposite sides 5 are deformed into a mountain shape, and the shape of the communication hole 4 is deformed from a horizontally long rectangle to a regular hexagon.
- the width of the band-like portions 7 and 8 around the communication hole 4 is about 30 ⁇ m, which is almost constant in all directions.
- the width (Sw) of the communication hole 4 is 3.3 times the height (Sh)
- the left and right belt-like portions 8 of the communication hole 4 are stretched in the stent circumferential direction as the diameter increases.
- the opposite side 5 deformed into a chevron is about twice as long as the side 6, and the communication hole 4 after diameter expansion forms a regular hexagon.
- the communication holes 4 and the surrounding belt-like portions 7 and 8 after the diameter expansion are formed by making the shape and arrangement size of the communication holes 4 before the stent diameter expansion different. It can be set to another shape.
- FIG. 5A shows Sh as 1.0, Sw as 3.7, Ph as 6.7, Pw as 4.0, Mh as 2.3, and Mw as 0.3.
- FIG. 5B shows Sh as 1.0, Sw as 3.7, Ph as 4.0, Pw as 6.7, Mh as 1.0, and Mw as 3.0.
- FIG. 5C shows Sh as 1.0, Sw as 7.0, Ph as 5.6, Pw as 8.8, Mh as 1.8, and Mw as 1.8.
- the width (Mw) of the left and right belt-like portions 8 of the communication hole 4 is smaller than the width (Sw) of the communication hole 4 in the stent central axis direction, and the ends of the communication holes 4 are connected to each other. It can be seen that the communication hole 4 can be deformed into a hexagonal shape after diameter expansion by overlapping in the stent circumferential direction.
- the width (Mh) of the upper and lower belt-like portions 7 of the communication hole 4 and the width (Mw) of the left and right belt-like portions 8 of the communication hole 4 are, for example, 0.5 ⁇ Mw / Mh ⁇ 2 It is understood that the widths of the band-like portions 7 and 8 can be made substantially constant even after the diameter expansion by setting substantially the same as 0.0.
- the shape of the communication hole 4 after the diameter expansion becomes a rhombus.
- Sw / Sh 10
- the shape of the communication hole 4 after the diameter expansion can be said to be approximately a rhombus.
- a method for manufacturing the stent 1 will be described.
- a cylindrical mandrel made of stainless steel is immersed in a polyurethane solution, and a polyurethane film is coated on the outer surface of the mandrel.
- the stent body 2 having a diameter of 3 mm is closely attached to the outside of the polyurethane film, and then strongly overlapped.
- the stent body 2 is immersed in a polyurethane solution to form a film, and the polyurethane film is coated on both surfaces of the stent body 2 so that the stent body 2 is integrated.
- a polyurethane film having a thickness of about 20 ⁇ m is formed.
- the polyurethane solution is, for example, a 12% by weight solution of segmented polyurethane with respect to tetrahydrofuran (for example, Milactolan (registered trademark) manufactured by Nihon Milactolan).
- the polyurethane film protruding from both ends of the stent body 2 is cut out and immersed in ethanol, and the stent body 2 and the polyurethane film integrated with the stent body 2 are extracted from the mandrel. Thereafter, by using an excimer laser or the like, the horizontally long rectangular communication holes 4 are formed in a plurality of rows in the polyurethane film integrated with the stent body 2 to form the tubular film 3, and the manufacture of the stent 1 is completed.
- the band-shaped portions 7 and 8 having a constant width are formed around the communication hole 4 in the diameter-expanded state, it is possible to prevent the wide portion from being formed without reducing the strength of the tubular film 3. Endothelial cells can easily penetrate into almost the entire inside of the stent to promote endothelialization of the inner surface of the stent, and blockage of the branch blood vessels due to the wide portion of the tubular film 3 can be prevented. Moreover, since the diameter of the stent 1 is expanded and the communication hole 4 is deformed from a horizontally long rectangle to a hexagon, the formation of the communication hole 4 can be facilitated.
- this invention is not limited to said embodiment, A change can be suitably added within the scope of the present invention.
- a pair of opposite sides are parallel to the stent central axis direction in the state before diameter expansion of the stent body 2 instead of the laterally long rectangular communication holes 4.
- the pair of opposite sides is deformed into a mountain shape while expanding the stent body 2 (FIG. 6 (b)).
- the shape of the communication hole 9 can be a rhombus, and a band-like portion having a constant width can be formed around the communication hole 9 (FIG. 6C).
- an elliptical communication hole 10 whose major axis is parallel to the stent central axis direction before the diameter expansion of the stent body 2 may be formed in the tubular film 3 before diameter expansion.
- the communicating hole 10 before diameter expansion into a horizontally long oval shape (FIG. 7 (a))
- the both sides of the major axis are deformed into a mountain shape while expanding the stent body 2 (FIG. 7 (b))
- the shape of the communication hole 10 after the diameter expansion can be formed into a rhombus, and a band-like portion having a constant width can be formed around the communication hole 10 (FIG. 7C).
- a band-like portion having a constant width is formed between the communication holes after the diameter expansion, and the shape of the communication holes before the diameter expansion is not particularly limited.
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Prostheses (AREA)
Abstract
Description
2 ステント本体
3 管状フィルム
4 連通孔
5 対辺
6 側辺
7 帯状部分
8 帯状部分
9 連通孔
10 連通孔
Claims (7)
- 拡径可能なステント本体と、該ステント本体に保持された管状フィルムとを備え、前記管状フィルムに、内外を連通する複数の連通孔が形成されると共に、互いに隣接する連通孔の間に、ステント本体の拡径状態で一定幅をなす帯状部分が形成されたことを特徴とするステント。
- 前記連通孔は、ステント本体の拡径状態で六角形に設定されたことを特徴とする請求項1に記載のステント。
- 前記連通孔は、ステント本体の拡径状態で菱形に設定されたことを特徴とする請求項1に記載のステント。
- 拡径可能なステント本体と、該ステント本体に保持された管状フィルムとを備え、前記管状フィルムに、内外を連通する複数の連通孔がステント周方向かつ複数列に配列され、該複数列の連通孔は、ステント周方向の位置を交互にずらして形成されると共に、互いに隣接する列の連通孔がステント中心軸方向における端部同士をステント周方向に重ねて形成されたことを特徴とするステント。
- 前記連通孔は、ステント本体の拡径前の状態で一対の対辺がステント中心軸方向と平行な長方形に設定されたことを特徴とする請求項4に記載のステント。
- 前記連通孔は、ステント本体の拡径前の状態で一対の対辺がステント中心軸方向と平行な六角形に設定されたことを特徴とする請求項4に記載のステント。
- 前記連通孔は、ステント本体の拡径前の状態で長軸がステント中心軸方向と平行な楕円形に設定されたことを特徴とする請求項4に記載のステント。
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15807438.5A EP3156011A4 (en) | 2014-06-12 | 2015-06-11 | Stent |
US15/317,571 US20170128244A1 (en) | 2014-06-12 | 2015-06-11 | Stent |
JP2016527852A JP6711748B2 (ja) | 2014-06-12 | 2015-06-11 | ステント |
CN201580030800.0A CN106456345B (zh) | 2014-06-12 | 2015-06-11 | 支架 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014121080 | 2014-06-12 | ||
JP2014-121080 | 2014-06-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2015190541A1 true WO2015190541A1 (ja) | 2015-12-17 |
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US (1) | US20170128244A1 (ja) |
EP (1) | EP3156011A4 (ja) |
JP (2) | JP6711748B2 (ja) |
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CN107115165A (zh) * | 2017-05-11 | 2017-09-01 | 常州大学 | 一种加筋硅酮气道支架的制备技术 |
JPWO2022259382A1 (ja) * | 2021-06-08 | 2022-12-15 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006118248A1 (ja) * | 2005-04-28 | 2006-11-09 | Japan Science And Technology Agency | 細胞増殖抑制部材、細胞転移抑制部材、細胞増殖抑制方法、細胞転移抑制方法、積層フィルムおよび医療用具 |
JP2011156083A (ja) * | 2010-01-29 | 2011-08-18 | Nippon Zeon Co Ltd | 消化器系ステント |
WO2012011269A1 (ja) * | 2010-07-20 | 2012-01-26 | 株式会社 京都医療設計 | ステント用カバー部材及びステント装置 |
WO2013191005A1 (ja) * | 2012-06-18 | 2013-12-27 | 株式会社パイオラックスメディカルデバイス | ステント |
JP2014508569A (ja) * | 2011-01-14 | 2014-04-10 | ダブリュ.エル.ゴア アンド アソシエイツ,インコーポレイティド | ステント |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6334868B1 (en) * | 1999-10-08 | 2002-01-01 | Advanced Cardiovascular Systems, Inc. | Stent cover |
EP1550477B1 (en) * | 2002-08-23 | 2015-11-04 | National Cerebral and Cardiovascular Center | Stent and process for producing the same |
JP4512351B2 (ja) * | 2003-11-28 | 2010-07-28 | ゼオンメディカル株式会社 | 消化器系ステント |
CN2863015Y (zh) * | 2004-11-24 | 2007-01-31 | 深圳市先健科技股份有限公司 | 主动脉术中支架及其输送系统 |
WO2008034007A2 (en) * | 2006-09-15 | 2008-03-20 | Boston Scientific Limited | Medical devices |
US9622888B2 (en) * | 2006-11-16 | 2017-04-18 | W. L. Gore & Associates, Inc. | Stent having flexibly connected adjacent stent elements |
US8926688B2 (en) * | 2008-01-11 | 2015-01-06 | W. L. Gore & Assoc. Inc. | Stent having adjacent elements connected by flexible webs |
BRPI1009556A2 (pt) * | 2009-03-06 | 2019-09-24 | Univ California | implanta vascular, método para gerar uma camada super hidrofílica sobre a superfície de um implante vascular, método de formar uma folha de película fina de níquel titânio, folha de película fina hidrofílica de níquel titânio, sistema e método para tratar uma condição vascular. |
US20130211489A1 (en) * | 2010-02-10 | 2013-08-15 | Apertomed L.L.C. | Methods, Systems and Devices for Treatment of Cerebrospinal Venous Insufficiency and Multiple Sclerosis |
WO2011150118A2 (en) * | 2010-05-25 | 2011-12-01 | The Regents Of The University Of California | Ultra-low fractional area coverage flow diverter for treating aneurysms and vascular diseases |
JP5824794B2 (ja) * | 2010-09-03 | 2015-12-02 | 国立研究開発法人国立循環器病研究センター | 動脈瘤治療用ステント |
CN202515718U (zh) * | 2012-03-23 | 2012-11-07 | 微创医疗器械(上海)有限公司 | 覆膜支架 |
CN103598928B (zh) * | 2013-10-25 | 2015-12-09 | 青岛文创科技有限公司 | 分支型覆膜支架及其输送系统 |
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2015
- 2015-06-11 WO PCT/JP2015/066805 patent/WO2015190541A1/ja active Application Filing
- 2015-06-11 CN CN201580030800.0A patent/CN106456345B/zh active Active
- 2015-06-11 US US15/317,571 patent/US20170128244A1/en active Pending
- 2015-06-11 JP JP2016527852A patent/JP6711748B2/ja active Active
- 2015-06-11 EP EP15807438.5A patent/EP3156011A4/en active Pending
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Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006118248A1 (ja) * | 2005-04-28 | 2006-11-09 | Japan Science And Technology Agency | 細胞増殖抑制部材、細胞転移抑制部材、細胞増殖抑制方法、細胞転移抑制方法、積層フィルムおよび医療用具 |
JP2011156083A (ja) * | 2010-01-29 | 2011-08-18 | Nippon Zeon Co Ltd | 消化器系ステント |
WO2012011269A1 (ja) * | 2010-07-20 | 2012-01-26 | 株式会社 京都医療設計 | ステント用カバー部材及びステント装置 |
JP2014508569A (ja) * | 2011-01-14 | 2014-04-10 | ダブリュ.エル.ゴア アンド アソシエイツ,インコーポレイティド | ステント |
WO2013191005A1 (ja) * | 2012-06-18 | 2013-12-27 | 株式会社パイオラックスメディカルデバイス | ステント |
Non-Patent Citations (1)
Title |
---|
See also references of EP3156011A4 * |
Also Published As
Publication number | Publication date |
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JP6711748B2 (ja) | 2020-06-17 |
JPWO2015190541A1 (ja) | 2017-04-20 |
CN106456345B (zh) | 2021-11-23 |
JP2020124642A (ja) | 2020-08-20 |
CN106456345A (zh) | 2017-02-22 |
EP3156011A4 (en) | 2018-02-14 |
EP3156011A1 (en) | 2017-04-19 |
US20170128244A1 (en) | 2017-05-11 |
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