WO2015180593A1 - Dérivés de benzodiallyle hétérocycliques ayant une activité antivirale - Google Patents

Dérivés de benzodiallyle hétérocycliques ayant une activité antivirale Download PDF

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Publication number
WO2015180593A1
WO2015180593A1 PCT/CN2015/079652 CN2015079652W WO2015180593A1 WO 2015180593 A1 WO2015180593 A1 WO 2015180593A1 CN 2015079652 W CN2015079652 W CN 2015079652W WO 2015180593 A1 WO2015180593 A1 WO 2015180593A1
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WO
WIPO (PCT)
Prior art keywords
alkyl
independently
ring
group
membered
Prior art date
Application number
PCT/CN2015/079652
Other languages
English (en)
Chinese (zh)
Inventor
张所明
Original Assignee
上海唐润医药科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 上海唐润医药科技有限公司 filed Critical 上海唐润医药科技有限公司
Publication of WO2015180593A1 publication Critical patent/WO2015180593A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems

Abstract

Cette invention concerne des dérivés de benzodiallyle hétérocycliques représentés par la formule (I), où quand A1 est O ou S, A2 est CR2 et A3 est C(R7)(R8) ; quand A2 est O ou S, A1 est C(R7)(R8) et A3 est CR2 ; quand A3 est O ou S, A1 est C(R7)(R8) et A2 est CR2 ; et Z1, Z2 sont indépendamment ou tous deux liés au R1 voisin pour former ensemble un cycle aromatique, un cycle hétéroaromatique, un cycle naphténique, un cycle hétéronaphténique ou sont des liaisons. Les dérivés de benzodiallyle hétérocycliques selon l'invention manifestent une excellente activité contre le virus de l'hépatite C.
PCT/CN2015/079652 2014-05-30 2015-05-25 Dérivés de benzodiallyle hétérocycliques ayant une activité antivirale WO2015180593A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201410240925.3 2014-05-30
CN201410240925.3A CN105272972B (zh) 2014-05-30 2014-05-30 具有抗病毒活性的苯并杂环己二烯衍生物

Publications (1)

Publication Number Publication Date
WO2015180593A1 true WO2015180593A1 (fr) 2015-12-03

Family

ID=54698080

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2015/079652 WO2015180593A1 (fr) 2014-05-30 2015-05-25 Dérivés de benzodiallyle hétérocycliques ayant une activité antivirale

Country Status (2)

Country Link
CN (1) CN105272972B (fr)
WO (1) WO2015180593A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010091413A1 (fr) * 2009-02-09 2010-08-12 Enanta Pharmaceuticals, Inc. Dérivés du dibenzimidazole liés
US20100316607A1 (en) * 2009-06-16 2010-12-16 Yat Sun Or Hepatitis c virus inhibitors
WO2010148006A1 (fr) * 2009-06-16 2010-12-23 Enanta Pharmaceuticals, Inc. Inhibiteurs du virus de l'hépatite c
WO2011031904A1 (fr) * 2009-09-11 2011-03-17 Enanta Pharmaceuticals, Inc Inhibiteurs du virus de l'hépatite c
WO2011081918A1 (fr) * 2009-12-14 2011-07-07 Enanta Pharmaceuticals, Inc Inhibiteurs du virus de l'hépatite c

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120195857A1 (en) * 2010-08-12 2012-08-02 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010091413A1 (fr) * 2009-02-09 2010-08-12 Enanta Pharmaceuticals, Inc. Dérivés du dibenzimidazole liés
US20100316607A1 (en) * 2009-06-16 2010-12-16 Yat Sun Or Hepatitis c virus inhibitors
WO2010148006A1 (fr) * 2009-06-16 2010-12-23 Enanta Pharmaceuticals, Inc. Inhibiteurs du virus de l'hépatite c
WO2011031904A1 (fr) * 2009-09-11 2011-03-17 Enanta Pharmaceuticals, Inc Inhibiteurs du virus de l'hépatite c
WO2011081918A1 (fr) * 2009-12-14 2011-07-07 Enanta Pharmaceuticals, Inc Inhibiteurs du virus de l'hépatite c

Also Published As

Publication number Publication date
CN105272972A (zh) 2016-01-27
CN105272972B (zh) 2018-12-11

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