WO2023280290A1 - Dérivé de pyrrole sulfonyle, son procédé de préparation et son utilisation - Google Patents

Dérivé de pyrrole sulfonyle, son procédé de préparation et son utilisation Download PDF

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WO2023280290A1
WO2023280290A1 PCT/CN2022/104528 CN2022104528W WO2023280290A1 WO 2023280290 A1 WO2023280290 A1 WO 2023280290A1 CN 2022104528 W CN2022104528 W CN 2022104528W WO 2023280290 A1 WO2023280290 A1 WO 2023280290A1
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mmol
alkyl
compound
synthesis
room temperature
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Chinese (zh)
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罗明
向俊峰
何锦
刘军华
王衡新
邓俐丽
宋志林
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天地恒一制药股份有限公司
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/402—1-aryl substituted, e.g. piretanide
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    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

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Abstract

La présente invention concerne une classe de dérivés de pyrrole sulfonyle, leur procédé de préparation, une composition pharmaceutique les contenant, et leur utilisation dans la préparation d'un médicament. Plus particulièrement, la présente invention concerne un dérivé de pyrrole sulfonyle tel que représenté par la formule générale (I), son procédé de préparation, une composition pharmaceutique le contenant et son utilisation en tant qu'agent thérapeutique, en particulier en tant qu'inhibiteur de sécrétion d'acide gastrique et bloqueur d'acide compétitif au potassium (P-CAB).
PCT/CN2022/104528 2021-07-09 2022-07-08 Dérivé de pyrrole sulfonyle, son procédé de préparation et son utilisation WO2023280290A1 (fr)

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CN101300229A (zh) * 2005-08-30 2008-11-05 武田药品工业株式会社 作为胃酸分泌抑制剂的1-杂环基磺酰基、2-氨基甲基、5-(杂)芳基取代的1-h-吡咯衍生物
WO2014019442A1 (fr) * 2012-08-03 2014-02-06 上海恒瑞医药有限公司 Dérivés de benzofurane, procédé de préparation et utilisation médicale de ceux-ci
US20140343070A1 (en) * 2004-09-30 2014-11-20 Takeda Pharmaceutical Company Limited Proton pump inhibitors
CN105330647A (zh) * 2014-08-14 2016-02-17 江苏柯菲平医药股份有限公司 吡咯磺酰类衍生物、其制备方法及其在医药上的应用
CN107875387A (zh) * 2016-09-29 2018-04-06 江苏柯菲平医药股份有限公司 一种含有吡咯磺酰类衍生物的复方药物及其用途
CN108558831A (zh) * 2018-06-08 2018-09-21 上海璃道医药科技有限公司 取代吡咯-4-烷基胺类化合物及其用途

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1628957B1 (fr) * 2003-05-26 2010-09-29 Takeda Pharmaceutical Company Limited Derives de sulfopyrrole
CN105985278A (zh) * 2015-01-27 2016-10-05 江苏柯菲平医药股份有限公司 吡咯磺酰类衍生物、其制备方法及其在医药上的应用

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140343070A1 (en) * 2004-09-30 2014-11-20 Takeda Pharmaceutical Company Limited Proton pump inhibitors
CN101300229A (zh) * 2005-08-30 2008-11-05 武田药品工业株式会社 作为胃酸分泌抑制剂的1-杂环基磺酰基、2-氨基甲基、5-(杂)芳基取代的1-h-吡咯衍生物
WO2014019442A1 (fr) * 2012-08-03 2014-02-06 上海恒瑞医药有限公司 Dérivés de benzofurane, procédé de préparation et utilisation médicale de ceux-ci
CN105330647A (zh) * 2014-08-14 2016-02-17 江苏柯菲平医药股份有限公司 吡咯磺酰类衍生物、其制备方法及其在医药上的应用
CN107875387A (zh) * 2016-09-29 2018-04-06 江苏柯菲平医药股份有限公司 一种含有吡咯磺酰类衍生物的复方药物及其用途
CN108558831A (zh) * 2018-06-08 2018-09-21 上海璃道医药科技有限公司 取代吡咯-4-烷基胺类化合物及其用途

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