WO2015064596A1 - Contenant pour gouttes ophtalmiques - Google Patents

Contenant pour gouttes ophtalmiques Download PDF

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Publication number
WO2015064596A1
WO2015064596A1 PCT/JP2014/078673 JP2014078673W WO2015064596A1 WO 2015064596 A1 WO2015064596 A1 WO 2015064596A1 JP 2014078673 W JP2014078673 W JP 2014078673W WO 2015064596 A1 WO2015064596 A1 WO 2015064596A1
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WO
WIPO (PCT)
Prior art keywords
nozzle
container
cap
ophthalmic
ophthalmic container
Prior art date
Application number
PCT/JP2014/078673
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English (en)
Japanese (ja)
Inventor
繁彦 小久保
Original Assignee
ロート製薬株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ロート製薬株式会社 filed Critical ロート製薬株式会社
Publication of WO2015064596A1 publication Critical patent/WO2015064596A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein

Definitions

  • the present invention relates to an eye drop container for containing eye drops (eye drops).
  • ophthalmic containers Conventionally, it includes a container body with a nozzle and a cap that is detachably attached to the container body.
  • ophthalmic containers are generally known.
  • Patent Document 1 as one type of eye drop container, when a cap is attached to a container body, a shaft-shaped plug portion formed on the cap side is inserted into the nozzle hole (lightly press-fitted), and the plug is inserted. The nozzle opening is closed by the part. According to such an eye drop container, liquid leakage from the nozzle can be prevented while being carried.
  • an eye drop container has been considered in which the diameter of the nozzle is reduced and the amount of eye drops once applied, for example, about 40-50 ⁇ l, is about half of that amount, for example, about 20-30 ⁇ l.
  • the diameter of the nozzle hole is relatively small, and the cap portion on the cap side is also made smaller. For this reason, it becomes difficult to manage the dimensions of the nozzle hole and the plug portion, and it is difficult to reliably prevent liquid leakage from the nozzle.
  • the nozzle is formed of an elastomer, a soft resin, or the like, if the plug portion is inserted into the nozzle hole for a long period of time, the nozzle hole may be deformed (expanded) and cause liquid leakage. In the case of a conventional nozzle having a relatively large diameter, such a phenomenon does not occur because the periphery of the nozzle hole is thick.
  • An object of the present invention is to provide a technique capable of preventing liquid leakage from an eye drop container suitable for a small amount of eye drop without causing the disadvantage of causing deformation of a nozzle.
  • An ophthalmic container of the present invention comprises a container body provided with a nozzle through which ophthalmic solution is led out, and a cap removably attached to the container body, and the nozzle has a head portion provided with a nozzle hole.
  • the cap includes a side wall surrounding the nozzle, a ceiling connected to the side wall and opposed to the top of the nozzle, and a first protruding from the ceiling and inserted into the nozzle hole A plug portion, and a cylindrical second plug portion that protrudes at a position on a concentric circle centered on the first plug portion of the ceiling portion and contacts the outer peripheral surface of the head portion. It is.
  • FIG. 2 is a cross-sectional view taken along the line II-II in FIG. 1 showing the eye drop container.
  • FIG. 2 is a cross-sectional view taken along the line II-II in FIG. 1 showing the eye drop container.
  • An ophthalmic container (hereinafter abbreviated as “container”) C is a container body including a liquid container 10 in which an ophthalmic solution (eye drops) is stored and a nozzle 16 for deriving the eye drops stored in the liquid container 10. 1 and a cap 2 that is detachably attached to the container main body 1 so as to cover the nozzle 16.
  • the container C is a so-called twist cap type container.
  • the method of using the container C is the same as the conventional one. That is, when instilling ophthalmic solution, the tip of the nozzle 16 faces downward with the cap 20 removed, and the ophthalmic solution is dripped from the tip of the nozzle 16 by lightly pressing the liquid container 11.
  • the liquid container 10 has a flat shape in the front-rear direction (direction perpendicular to the paper surface of FIG. 1).
  • the liquid container 10 includes a liquid container 11 that can store about 10 to 15 ml of ophthalmic solution, a shoulder 12 that is connected to the upper side thereof, and a cylindrical mouth that is connected to the upper side and is located at the upper center of the liquid container 11. And neck 13.
  • the liquid container 10 has a configuration in which the liquid container 11, the shoulder 12, and the cylindrical mouth / neck 13 are integrally formed of a synthetic resin material such as polypropylene, polyethylene, or polyethylene terephthalate.
  • the nozzle 16 is fixed to the liquid container 10 by being inserted into the cylindrical mouth / neck portion 13.
  • the nozzle 16 includes a substantially spherical top portion 17 and a substantially truncated cone-shaped body that is connected to the lower side of the top portion 17 and extends in the vertical direction along the central axis of the nozzle 16.
  • the head portion 17, the body portion 18, the flange portion 19 and the leg portion 20 are integrated with a soft synthetic resin material such as low-density polyethylene, linear low-density polyethylene, high-density polyethylene, or polypropylene, or an elastomer. It has the structure shape
  • a soft synthetic resin material such as low-density polyethylene, linear low-density polyethylene, high-density polyethylene, or polypropylene, or an elastomer. It has the structure shape
  • the nozzle 16 has a nozzle hole 22 extending in the vertical direction from the tip of the head portion 17 to the lower end of the body portion 18 along the center line.
  • the ophthalmic solution in the liquid container 10 is led to the tip of the head portion 17 through the nozzle hole 22.
  • the outer diameter of the body portion 18 of the nozzle 16 gradually decreases from the flange portion 19 side toward the leading end portion 17 side (from the base end portion to the tip end portion). The area is gradually reduced).
  • the tip of the nozzle 16 is made thinner than the conventional container of this type (the container for eye drops described in the background art), and the diameter of the nozzle hole 22 is approximately 0. 0. 0. It is set to 5 mm to 1.5 mm. As a result, the amount of one eye drop can be suppressed to about 20 to 30 ⁇ l, for example.
  • the cap 2 is formed so as to cover the container body 1 above the shoulder portion 10. More specifically, the cap 2 includes a side wall portion 30 that surrounds the nozzle 16 and the cylindrical mouth-and-neck portion 13 and the like, and a ceiling portion 32 that is connected to the upper end of the side wall portion 30 and faces the head portion 17 of the nozzle 16. It has a crested cylindrical shape.
  • the side wall portion 30 and the ceiling portion 32 are integrally formed of a synthetic resin material such as polypropylene, polyethylene, polystyrene, etc., like the liquid container 10.
  • the side wall portion 30 has a side surface of the liquid storage portion 11 and a side surface of the cap 2 in a state where the cap 2 is mounted on the container body 1 (hereinafter simply referred to as a cap mounting state). It is configured to form a smooth outline line that is continuous in the vertical direction.
  • a shaft-shaped first plug portion 34 that protrudes downward (nozzle 16 side) from the center of the bottom surface is integrally formed on the ceiling portion 32 of the cap 2.
  • a cylindrical second plug portion 36 that protrudes downward from a position on a concentric circle centering on the first plug portion 34 is integrally formed on the ceiling portion 32 of the cap 2.
  • the first plug portion 34 is inserted into the nozzle hole 22 from the tip of the nozzle 16 to close the nozzle hole 22 in a cap mounted state.
  • the first plug portion 34 has a hemispherical distal end portion and is formed in a cross-sectional mountain shape whose outer diameter dimension gradually increases from the distal end side toward the proximal end side. With this configuration, when the cap is attached, the first plug portion 34 is inserted into the nozzle hole 22 so that the outer peripheral surface of the first plug portion 34 is in close contact with the opening edge of the nozzle hole 22.
  • the second plug portion 36 substantially closes the nozzle 16 by being in close contact with the outer peripheral surface of the head portion 17 of the nozzle 16 in the cap mounted state.
  • the inner diameter dimension D ⁇ b> 2 of the second plug part 36 is set to a value slightly smaller than the maximum diameter dimension D ⁇ b> 1 of the head part 17 of the nozzle 16.
  • the second plug portion 36 is in close contact with the nozzle 16 from the outside only at the position of the substantially maximum diameter of the head portion 17 formed in a spherical shape in the cap mounted state.
  • a taper portion for inviting the nozzle 16 (leading portion 17) to the inside of the second plug portion 36 when the cap 2 is attached to the container body 1 is provided inside the tip (lower end) of the second plug portion 36. 36a is formed.
  • the ceiling portion 32 of the cap 2 is further provided with a pair of locking arms extending downward from the positions of the lower surfaces of the cap portions 34 and 36 on both the left and right sides (left and right sides in FIG. 1). 38 is integrally formed.
  • These locking arms 38 lock the cap 2 attached to the container main body 1 to the container main body 1, and the cap 2 is attached to the container main body 1 when the cap 2 is attached to the container main body 1. It is a guide.
  • a locking projection 13 a is formed on the outer peripheral surface of the base end portion of the cylindrical mouth-neck portion 13 of the liquid container 10.
  • a locking recess 38 a is formed in the vicinity of the tip of the opposing surface of each locking arm 38.
  • each of the locking arms 38 is formed so that the opposing surface has an arc shape so as to correspond to the outer peripheral surface shape of the cylindrical mouth-and-neck portion 13 over the entire arm longitudinal direction, and the opposing surface is a cylindrical mouth.
  • the interval is set so as to come into contact with the outer peripheral surface of the neck 13 from both the left and right sides.
  • the cap 2 is rotated about 90 ° around the cylindrical mouth-neck portion 13 from the cap-mounted state shown in FIG. 1, thereby removing the cap 2 from the container body 1.
  • the cap 2 rides on the shoulder portion 12 of the liquid container 10, and the cap 2 is pushed upward along with this riding. Thereby, the latching state of each latching arm 38 with respect to the cylindrical mouth neck part 13 is cancelled
  • the cap 2 is attached along the cylindrical mouth and neck 13 of the container body 1 (liquid container 10). Specifically, the cap body 2 is covered with the cap 2 so that the nozzle 16 and the cylindrical mouth-neck portion 13 are inserted between the locking arms 38, and the cap 2 is guided along the cylindrical mouth-neck portion 13. Then, the cap 2 is pushed into the container body 1 side.
  • the first plug portion 34 of the cap 2 is inserted into the nozzle hole 22 and the nozzle hole 22 is closed as shown in FIG.
  • the top portion 17 of the nozzle 16 is inserted inside the second plug portion 36, and the inner peripheral surface of the second plug portion 36 is in close contact with the nozzle 16 at the position of the substantially maximum diameter of the top portion 17.
  • the nozzle 16 is closed by the plug portions 34 and 36.
  • the locking projections 13 a of the cylindrical mouth and neck portion 13 are inserted into the locking recesses 38 a of the locking arms 38, whereby the cap 2 is locked to the container body 1.
  • the nozzle 16 is double-closed by the first plug portion 34 and the second plug portion 36 as described above. Precisely, the nozzle hole 22 is blocked by the first plug portion 34, thereby preventing liquid leakage from the nozzle hole 22. Even if the ophthalmic solution flows out from the nozzle hole 22, the second plug portion 36 is in close contact with the nozzle 16 (head portion 17) and the gap between the nozzle 16 and the second plug portion 36 is sealed. The ophthalmic solution is prevented from leaking outside the two-plug portion 36. Therefore, liquid leakage from the container C can be prevented to a high degree.
  • the second plug portion 36 is in contact with the nozzle 16 from the outside, even when the first plug portion 34 is inserted into the nozzle hole 22 for a long period of time, the deformation (expansion) of the nozzle hole 22 is performed. Is suppressed.
  • the spherical top portion 17 is formed on the nozzle 16 and the second stopper portion 36 contacts the nozzle 16 at the position of the substantially maximum diameter, so that the detachability operability of the cap 2 is hindered.
  • the ophthalmic solution can be prevented from leaking without inconvenience such as deformation of the nozzle 16 during the attaching / detaching operation. That is, in order to reliably prevent liquid leakage, it is necessary to bring the second plug portion 36 into close contact with the nozzle 16. In this case, resistance when the cap 2 is attached and detached increases, and operability is hindered. It is conceivable that the nozzle 16 itself is deformed.
  • the nozzle 16 and the second plug portion can be formed with a relatively small contact area where contact resistance does not become too large. It is possible to ensure a sufficient contact pressure with which 36 can be brought into close contact with each other, that is, a liquid-tight state can be achieved. Therefore, the ophthalmic solution can be highly prevented from leaking without the inconvenience such as hindering the detachability of the cap 2.
  • the cap 2 is attached. At this time, the nozzle 16 is smoothly guided to the inside of the second plug portion 36. Therefore, the nozzle 16 abuts against the end surface (lower end surface) of the second plug portion 36 and is prevented from being deformed.
  • the container C mentioned above is an illustration of preferable embodiment of the eye drop container which concerns on this invention.
  • the specific structure can be suitably changed in the range which does not deviate from the summary of this invention.
  • the body portion 18 of the nozzle 16 is formed such that the outer diameter dimension gradually decreases from the flange portion 19 (liquid container 10 side) toward the head portion 17.
  • the outer diameter dimension of the trunk portion 18 may be constant from the flange portion 19 to the head portion 17.
  • the constriction is formed at the connecting portion between the head portion 17 and the body portion 18, liquid breakage at the time of instillation is good.
  • the body portion 18 of the nozzle 16 is formed so that the outer surface changes in a curved shape in the direction along the central axis. It may be formed to change upward. Further, the cross-sectional shape of the body portion 18 of the nozzle 16 is not limited to a circle, but may be a quadrangle or a polygon more than that.
  • the shape of the leading portion 17 is “spherical”.
  • this “spherical” means that the leading end from the base end (body 18 side) toward the leading end. It means a shape in which the outer diameter of the portion 17 gradually increases and reaches a maximum diameter and then gradually decreases, and the outline of the leading portion 17 is rounded as a whole. Therefore, the head portion 17 is not limited to the shape described in FIG. 3 and the like, and can be appropriately changed within a range that matches the above definition.
  • An ophthalmic container of the present invention comprises a container body provided with a nozzle through which ophthalmic solution is led out, and a cap removably attached to the container body, and the nozzle has a head portion provided with a nozzle hole.
  • the cap includes a side wall surrounding the nozzle, a ceiling connected to the side wall and opposed to the top of the nozzle, and a first protruding from the ceiling and inserted into the nozzle hole A plug portion, and a cylindrical second plug portion that protrudes at a position on a concentric circle centered on the first plug portion of the ceiling portion and contacts the outer peripheral surface of the head portion. It is.
  • the nozzle hole is substantially double-closed by the first plug portion and the second plug portion, so that it is possible to prevent liquid leakage more reliably.
  • the second plug portion is in contact with the outer peripheral surface of the nozzle, deformation (expansion) of the nozzle hole is suppressed even when the first plug portion is inserted into the nozzle hole for a long time.
  • the top portion is spherical, and the inner peripheral surface of the second stopper portion is circular in a cross-sectional view.
  • the circular shape in a cross-sectional view does not mean only a strict true circle but also includes a slightly elliptical circle.
  • the nozzle and the second stopper can be satisfactorily brought into close contact with each other with a relatively small contact area where the contact resistance does not increase too much. Therefore, it is possible to highly suppress the ophthalmic solution from leaking without inconveniences such as hindering cap detachment operability and deformation of the nozzle.
  • the top portion of the nozzle is spherical, when the cap is mounted, the nozzle is easily guided to the inside of the second plug portion. Therefore, it is also suppressed that the nozzle hits the end surface of the second plug portion and the nozzle is deformed.
  • the second plug portion is in contact with the head portion at the position of the maximum diameter of the head portion.
  • the inner diameter of the second plug part is preferably smaller than the maximum diameter of the leading part.
  • the second stopper portion has a tapered portion on the inside.
  • the nozzle when the cap is mounted, the nozzle is more easily guided to the inside of the second plug portion, which is advantageous in suppressing deformation of the nozzle during the cap mounting operation.
  • the nozzle includes a body portion having a distal end portion extending along a predetermined central axis and connected to the leading end portion, and a proximal end portion opposite to the leading end portion,
  • the cross-sectional area of the trunk is preferably smaller at the tip than at the base. In this case, it is preferable that the cross-sectional area of the trunk portion gradually decreases from the base end portion toward the tip end portion. Further, it is preferable that the outer surface of the body portion is changed in a curved shape in a direction along the central axis.
  • the body portion may have a constant cross-sectional area from the base end portion to the tip end portion.
  • it is possible to ensure the rigidity of the entire nozzle while reducing the diameter of the nozzle tip and relatively reducing the amount of eye drops once. Therefore, it is advantageous in suppressing deformation of the nozzle due to contact with the outside. That is, it can be suitably used for an eye drop container designed so as to relatively reduce the amount of eye drop once.
  • each of the eye drop containers described above is also useful when the nozzle is made of an elastomer. That is, a flexible material such as an elastomer has a property that it is difficult to return to its original shape when the deformed state is maintained.
  • a flexible material such as an elastomer has a property that it is difficult to return to its original shape when the deformed state is maintained.
  • the plug portion is simply inserted into the nozzle hole, There was a possibility that the deformation of the nozzle may occur because only the force in the direction outward) is applied.
  • the second plug portion comes into contact with the nozzle hole from the outside in a state where the first plug portion is inserted into the nozzle hole, so that the nozzle is bi-directional (radially outward and radially inward). ), The deformation of the nozzle is suppressed.
  • the deformation of the nozzle is effectively suppressed.
  • a flexible material such as an elastomer that has heretofore been difficult to apply as the nozzle material. .

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Closures For Containers (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

La présente invention a pour objet de concevoir une fonctionnalité associée à un contenant pour gouttes ophtalmiques qui soit appropriée pour une petite quantité de gouttes ophtalmiques et qui puisse empêcher une fuite de la solution, sans avoir l'inconvénient de provoquer une déformation de buse. À cette fin, la présente invention concerne un contenant pour gouttes ophtalmiques comprenant les parties suivantes : un corps principal (1) de contenant comprenant une buse (16) à partir de laquelle une solution de gouttes ophtalmiques est délivrée ; et un bouchon (2) qui s'ajuste sur le corps principal de contenant de façon à pouvoir être retiré. La buse comprend une partie tête (17) comportant un trou de buse. Le bouchon comprend les parties suivantes : une partie paroi latérale (30) qui enferme la buse ; une partie supérieure (32) qui est reliée à la partie paroi latérale et qui fait face à la partie tête de la buse ; un premier obturateur (34) qui est disposé en saillie de la partie supérieure et qui s'introduit dans le trou de buse ; et une seconde partie obturateur tubulaire (36) qui est disposée en saillie de la partie supérieure au niveau d'une position d'un cercle concentrique dont la première partie obturateur constitue le centre.
PCT/JP2014/078673 2013-11-01 2014-10-28 Contenant pour gouttes ophtalmiques WO2015064596A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2013228483A JP6310674B2 (ja) 2013-11-01 2013-11-01 点眼用容器
JP2013-228483 2013-11-01

Publications (1)

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WO2015064596A1 true WO2015064596A1 (fr) 2015-05-07

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PCT/JP2014/078673 WO2015064596A1 (fr) 2013-11-01 2014-10-28 Contenant pour gouttes ophtalmiques

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WO (1) WO2015064596A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6653555B2 (ja) * 2015-11-19 2020-02-26 キタノ製作株式会社 液体注出塗布容器とその使用方法
JP6794285B2 (ja) * 2017-01-31 2020-12-02 株式会社吉野工業所 注出キャップ

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0323065U (fr) * 1989-07-11 1991-03-11
JP2004123220A (ja) * 2002-08-06 2004-04-22 Takeuchi Press Ind Co Ltd 容器の口部
JP2004196417A (ja) * 2002-10-23 2004-07-15 Rohto Pharmaceut Co Ltd 液体用容器のノズル構造
JP3145715U (ja) * 2008-08-06 2008-10-16 常盤薬品工業株式会社 液垂れおよび臭気漏れを防止する容器用口構造

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5543786Y2 (fr) * 1975-05-22 1980-10-15
JP5102686B2 (ja) * 2008-04-17 2012-12-19 伸晃化学株式会社 薬液容器の二重中栓

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0323065U (fr) * 1989-07-11 1991-03-11
JP2004123220A (ja) * 2002-08-06 2004-04-22 Takeuchi Press Ind Co Ltd 容器の口部
JP2004196417A (ja) * 2002-10-23 2004-07-15 Rohto Pharmaceut Co Ltd 液体用容器のノズル構造
JP3145715U (ja) * 2008-08-06 2008-10-16 常盤薬品工業株式会社 液垂れおよび臭気漏れを防止する容器用口構造

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JP2015085997A (ja) 2015-05-07
JP6310674B2 (ja) 2018-04-11

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