WO2014128189A1 - 2-aminopyrimidine derivatives for the treatment of viral infections - Google Patents

2-aminopyrimidine derivatives for the treatment of viral infections Download PDF

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Publication number
WO2014128189A1
WO2014128189A1 PCT/EP2014/053273 EP2014053273W WO2014128189A1 WO 2014128189 A1 WO2014128189 A1 WO 2014128189A1 EP 2014053273 W EP2014053273 W EP 2014053273W WO 2014128189 A1 WO2014128189 A1 WO 2014128189A1
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WO
WIPO (PCT)
Prior art keywords
compound
pharmaceutically acceptable
formula
polymorph
solvate
Prior art date
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PCT/EP2014/053273
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English (en)
French (fr)
Inventor
David Craig Mc Gowan
Pierre Jean-Marie Bernard Raboisson
Tim Hugo Maria Jonckers
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Janssen R&D Ireland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47739156&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2014128189(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to UAA201508985A priority Critical patent/UA118751C2/uk
Priority to AU2014220717A priority patent/AU2014220717B2/en
Priority to NZ709769A priority patent/NZ709769B2/en
Priority to KR1020217006452A priority patent/KR102300861B1/ko
Priority to MYPI2015702627A priority patent/MY191389A/en
Priority to ES14705356T priority patent/ES2733361T3/es
Priority to CN201480009711.3A priority patent/CN105189468B/zh
Priority to DK14705356.5T priority patent/DK2958900T3/da
Priority to EA201591524A priority patent/EA035174B1/ru
Priority to CA2897587A priority patent/CA2897587C/en
Priority to SG11201506639XA priority patent/SG11201506639XA/en
Application filed by Janssen R&D Ireland filed Critical Janssen R&D Ireland
Priority to US14/769,773 priority patent/US9598378B2/en
Priority to MX2015010856A priority patent/MX367915B/es
Priority to BR112015020118-0A priority patent/BR112015020118B1/pt
Priority to KR1020157022968A priority patent/KR102225233B1/ko
Priority to EP14705356.5A priority patent/EP2958900B1/en
Priority to JP2015558440A priority patent/JP6404835B2/ja
Publication of WO2014128189A1 publication Critical patent/WO2014128189A1/en
Priority to IL239859A priority patent/IL239859A0/en
Priority to PH12015501648A priority patent/PH12015501648A1/en
Priority to HK16101637.9A priority patent/HK1213569A1/zh
Priority to US15/464,050 priority patent/US10259793B2/en
Priority to AU2018204422A priority patent/AU2018204422A1/en
Priority to US16/382,816 priority patent/US10647684B2/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms

Definitions

  • This invention relates to 2-aminopyhnnidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
  • the present invention relates to the use of 2-aminopyrimidine derivatives in the treatment of viral infections, immune or inflammatory disorders, whereby the modulation, or agonism, of toll-like-receptors (TLRs) is involved.
  • TLRs toll-like-receptors
  • Toll-Like Receptors are primary transmembrane proteins characterized by an extracellular leucine rich domain and a cytoplasmic extension that contains a conserved region.
  • the innate immune system can recognize pathogen- associated molecular patterns via these TLRs expressed on the cell surface of certain types of immune cells. Recognition of foreign pathogens activates the production of cytokines and upregulation of co-stimulatory molecules on phagocytes. This leads to the modulation of T cell behaviour.
  • TLR1 to TLR13 TLRs
  • TLR1 to TLR13 TLRs
  • equivalent forms of many of these have been found in other mammalian species.
  • equivalents of certain TLR found in humans are not present in all mammals.
  • a gene coding for a protein analogous to TLR10 in humans is present in mice, but appears to have been damaged at some point in the past by a retrovirus.
  • mice express TLRs 1 1 , 12, and 13, none of which are represented in humans.
  • Other mammals may express TLRs which are not found in humans.
  • TLR14 may have TLRs distinct from mammals, as demonstrated by TLR14, which is found in the Takifugu pufferfish. This may complicate the process of using experimental animals as models of human innate immunity.
  • TLRs see the following journal articles. Hoffmann, J.A., Nature, 426, p33-38, 2003; Akira, S., Takeda, K., and Kaisho, T., Annual Rev. Immunology, 21 , p335-376, 2003; Ulevitch, R. J., Nature Reviews: Immunology, 4, p512-520, 2004.
  • Ri is hydrogen, (Ci-6)-alkyl, or aryl
  • the compounds of formula (I) and their pharmaceutically acceptable salts, tautomer(s), stereo-isomeric forms, solvate or polymorph thereof have activity as pharmaceuticals, in particular as modulators of Toll-Like Receptors (especially TLR7 and/or TLR8 activity).
  • the present invention provides a pharmaceutical composition
  • a pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt, tautomer, stereo-isomeric form, solvate or polymorph thereof together with one or more pharmaceutically acceptable excipients, diluents or carriers.
  • a compound of formula (I) or a pharmaceutically acceptable salt, solvate, tautomer, stereo-isomeric form or polymorph thereof according to the current invention, or a pharmaceutical composition comprising said compound of formula(l) or a pharmaceutically acceptable salt, solvate, tautomer, stereo- isomeric form or polymorph thereof can be used as a medicament.
  • a compound of formula (I) or its pharmaceutically acceptable salt, solvate, tautomer, stereo-isomeric form or polymorph thereof, or said pharmaceutical composition comprising said compound of formula (I) or a pharmaceutically acceptable salt, solvate, tautomer, stereo-isomeric form or polymorph thereof can be used accordingly in the treatment of a disorder where the modulation of TLR's, more specifically TLR7 and /or TLR8, is involved.
  • (C-i-3)-alkyl refers to a straight-chain, branched-chain or cyclic saturated aliphatic hydrocarbon containing the specified number of carbon atoms.
  • aryl means an aromatic ring structure optionally comprising one or two heteroatoms selected from N, O and S, in particular from N and O. Said aromatic ring structure may have 4, 5, 6 or 7 ring atoms. In particular, said aromatic ring structure may have 5 or 6 ring atoms.
  • (Ci -6 )-alkoxy refers to an alkyl (carbon and hydrogen chain) group singular bonded to oxygen like for instance a methoxy group or ethoxy group.
  • (C 3- 6)-cycloalkyl means refers to a carbocyclic ring containing the specified number of carbon atoms.
  • stereoisomers stereoisomers
  • stereoisomeric forms or “stereochemically isomeric forms” hereinbefore or hereinafter are used interchangeably.
  • the invention includes all stereoisomers of the compounds of the invention either as a pure stereoisomer or as a mixture of two or more stereoisomers.
  • Enantiomers are stereoisomers that are non-superimposable mirror images of each other.
  • a 1 :1 mixture of a pair of enantiomers is a racemate or racemic mixture.
  • Diastereomers are stereoisomers that are not enantiomers, i.e. they are not related as mirror images. If a compound contains a double bond, the substituents may be in the E or the Z configuration. If a compound contains an at least disubstituted non-aromatic cyclic group, the substituents may be in the cis or trans configuration. Therefore, the invention includes enantiomers, diastereomers, racemates, E isomers, Z isomers, cis isomers, trans isomers and mixtures thereof, whenever chemically possible.
  • the absolute configuration is specified according to the Cahn-lngold-Prelog system.
  • the configuration at an asymmetric atom is specified by either R or S.
  • Resolved stereoisomers whose absolute configuration is not known can be designated by (+) or (-) depending on the direction in which they rotate plane polarized light.
  • resolved enantiomers whose absolute configuration is not known can be designated by (+) or (-) depending on the direction in which they rotate plane polarized light.
  • stereoisomer is substantially free, i.e. associated with less than 50%, preferably less than 20%, more preferably less than 10%, even more preferably less than 5%, in particular less than 2% and most preferably less than 1 %, of the other stereoisomers.
  • a compound of Formula (I) is for instance specified as (R)
  • a compound of Formula (I) is for instance specified as E
  • this means that the compound is substantially free of the Z isomer
  • a compound of Formula (I) is for instance specified as cis, this means that the compound is substantially free of the trans isomer.
  • Pharmaceutically acceptable salts of the compounds of formula (I) include the acid addition and base salts thereof. Suitable acid addition salts are formed from acids which form non-toxic salts. Suitable base salts are formed from bases which form non-toxic salts.
  • the compounds of the invention may also exist in unsolvated and solvated forms.
  • solvate is used herein to describe a molecular complex comprising the compound of the invention and one or more pharmaceutically acceptable solvent molecules, for example, ethanol.
  • polymorph refers to the ability of the compound of the invention to exist in more than one form or crystal structure.
  • the compounds of the present invention may be administered as crystalline or amorphous products. They may be obtained for example as solid plugs, powders, or films by methods such as precipitation, crystallization, freeze drying, spray drying, or evaporative drying. They may be administered alone or in combination with one or more other compounds of the invention or in combination with one or more other drugs. Generally, they will be administered as a formulation in association with one or more pharmaceutically acceptable excipients.
  • excipient is used herein to describe any ingredient other than the compound(s) of the invention. The choice of excipient depends largely on factors such as the particular mode of administration, the effect of the excipient on solubility and stability, and the nature of the dosage form.
  • compositions of the present invention may be formulated into various pharmaceutical forms for administration purposes.
  • compositions there may be cited all compositions usually employed for systemically administering drugs.
  • an effective amount of the particular compound, optionally in addition salt form, as the active ingredient is combined in intimate admixture with a pharmaceutically acceptable carrier, which carrier may take a wide variety of forms depending on the form of preparation desired for administration.
  • a pharmaceutically acceptable carrier which carrier may take a wide variety of forms depending on the form of preparation desired for administration.
  • These pharmaceutical compositions are desirably in unitary dosage form suitable, for example, for oral, rectal, or percutaneous administration.
  • any of the usual pharmaceutical media may be employed such as, for example, water, glycols, oils, alcohols and the like in the case of oral liquid preparations such as suspensions, syrups, elixirs, emulsions, and solutions; or solid carriers such as starches, sugars, kaolin, diluents, lubricants, binders, disintegrating agents and the like in the case of powders, pills, capsules, and tablets. Because of their ease in administration, tablets and capsules represent the most advantageous oral dosage unit forms, in which case solid pharmaceutical carriers are obviously employed. Also included are solid form preparations that can be converted, shortly before use, to liquid forms.
  • the carrier optionally comprises a penetration enhancing agent and/or a suitable wetting agent, optionally combined with suitable additives of any nature in minor proportions, which additives do not introduce a significant deleterious effect on the skin. Said additives may facilitate the administration to the skin and/or may be helpful for preparing the desired compositions.
  • These compositions may be administered in various ways, e.g., as a transdermal patch, as a spot-on, as an ointment.
  • the compounds of the present invention may also be administered via inhalation or insufflation by means of methods and formulations employed in the art for administration via this way.
  • the compounds of the present invention may be administered to the lungs in the form of a solution, a suspension or a dry powder. It is especially advantageous to formulate the aforementioned pharmaceutical compositions in unit dosage form for ease of administration and uniformity of dosage.
  • Unit dosage form as used herein refers to physically discrete units suitable as unitary dosages, each unit containing a predetermined quantity of active ingredient calculated to produce the desired therapeutic effect in association with the required pharmaceutical carrier. Examples of such unit dosage forms are tablets (including scored or coated tablets), capsules, pills, powder packets, wafers, suppositories, injectable solutions or suspensions and the like, and segregated multiples thereof.
  • an effective daily amount would be from 0.01 mg/kg to 50 mg/kg body weight, more preferably from 0.1 mg/kg to 10 mg/kg body weight. It may be appropriate to administer the required dose as two, three, four or more sub-doses at appropriate intervals throughout the day. Said sub-doses may be formulated as unit dosage forms, for example, containing 1 to 1000 mg, and in particular 5 to 200 mg of active ingredient per unit dosage form.
  • the exact dosage and frequency of administration depends on the particular compound of formula (I) used, the particular condition being treated, the severity of the condition being treated, the age, weight and general physical condition of the particular patient as well as other medication the individual may be taking, as is well known to those skilled in the art. Furthermore, it is evident that the effective amount may be lowered or increased depending on the response of the treated subject and/or depending on the evaluation of the physician prescribing the compounds of the instant invention. The effective amount ranges mentioned above are therefore only guidelines and are not intended to limit the scope or use of the invention to any extent.
  • Triethylamine (10.5 g, 103.75 mmol, 2.4 eq.) was added to the solution of A (10 g, 43.23 mmol, 1 eq.) in CH 2 CI 2 (200 mL) at 0°C.
  • Methanesulfonyl chloride (6.4 g, 55.87 mmol, 1 .3 eq.) was added dropwise to the solution and stirred 1 .5 hours at 0°C. CH2CI2 (500 mL) was added.
  • the solution was washed with aq. NaHCO3, brine, and dried over Na2SO 4 , the solids were removed by filtration and the solvent of the filtrate was removed under reduced pressure to give B. Used as such without further purification.
  • HEK293 cells transiently transfected with a TLR7 or TLR8 expression vector and NFKB-IUC reporter construct. Briefly, HEK293 cells were grown in culture medium (DMEM supplemented with 10% FCS and 2 mM Glutamine). For transfection of cells in 15 cm dishes, cells were detached with Trypsin-EDTA, transfected with a mix of CMV-TLR7 or TLR8 plasmid (1700 ng), NFKB-IUC plasmid (850 ng) and a transfection reagent and incubated for 48 h at 37°C in a humidified 5% CO2 atmosphere.
  • Transfected cells were then washed in PBS, detached with Trypsin-EDTA and resuspended in medium to a density of 1 .25 x 10 5 cells/mL. Forty microliters of cells were then dispensed into each well in 384-well plates, where 200 nL of compound in 100% DMSO was already present. Following 6 hours incubation at 37°C, 5% CO 2 , the luciferase activity was deternnined by adding 15 ⁇ _ of Steady Lite Plus substrate (Perkin Elmer) to each well and readout performed on a ViewLux ultraHTS microplate imager (Perkin Elmer). Dose response curves were generated from measurements performed in quadruplicates. Lowest effective concentrations (LEC) values, defined as the concentration that induces an effect which is at least two fold above the standard deviation of the assay, were determined for each compound.
  • LEC Lowest effective concentrations
  • Compound toxicity was determined in parallel using a similar dilution series of compound with 40 ⁇ per well of cells transfected with the CMV-TLR7 construct alone (1 .25 x 10 5 cells/mL), in 384-well plates. Cell viability was measured after 6 hours incubation at 37°C, 5% CO2 by adding 15 ⁇ of ATP lite (Perkin Elmer) per well and reading on a ViewLux ultraHTS microplate imager (Perkin Elmer). Data was reported as CC50.
  • the potential of compounds to induce IFN-I was also evaluated by measuring the activation of interferon-stimulated responsive elements (ISRE) by conditioned media from PBMC.
  • ISRE interferon-stimulated responsive elements
  • the ISRE element of sequence GAAACTGAAACT is highly responsive to the STAT1 -STAT2-IRF9 transcription factor, activated upon binding of IFN-I to their receptor IFNAR (Clontech, PT3372-5W).
  • the plasmid pISRE-Luc from Clontech contains 5 copies of this ISRE element, followed by the firefly luciferase ORF.
  • a HEK293 cell line stably transfected with pISRE-Luc (HEK-ISREluc) was established to profile the conditioned PBMC cell culture media.
  • PBMCs were prepared from buffy coats of at least two donors using a standard Ficoll centrifugation protocol. Isolated PBMCs were resuspended in RPMI medium supplemented with 10% human AB serum and 2 x 10 5 cells/well were dispensed into 384-well plates containing compounds (70 ⁇ total volume). After overnight incubation, 10 ⁇ _ of supernatant was transferred to 384-well plates containing 5 x 10 3 HEK-ISREluc cells/well in 30 ⁇ _ (plated the day before).
  • NA not available. All compounds showed no toxicity up to the highest tested concentration. All compounds showed no activity (LEC >25 ⁇ ) in the HEK 293 NF-kB counterscreen assay described above.

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PCT/EP2014/053273 2013-02-21 2014-02-20 2-aminopyrimidine derivatives for the treatment of viral infections WO2014128189A1 (en)

Priority Applications (23)

Application Number Priority Date Filing Date Title
JP2015558440A JP6404835B2 (ja) 2013-02-21 2014-02-20 ウイルス感染の治療のための２−アミノピリミジン誘導体
MX2015010856A MX367915B (es) 2013-02-21 2014-02-20 Derivados de 2-aminopirimidina para el tratamiento de infecciones viricas.
US14/769,773 US9598378B2 (en) 2013-02-21 2014-02-20 2-aminopyrimidine derivatives for the treatment of viral infections
KR1020217006452A KR102300861B1 (ko) 2013-02-21 2014-02-20 바이러스 감염의 치료를 위한 2-아미노피리미딘 유도체
AU2014220717A AU2014220717B2 (en) 2013-02-21 2014-02-20 2-aminopyrimidine derivatives for the treatment of viral infections
ES14705356T ES2733361T3 (es) 2013-02-21 2014-02-20 Derivados de 2-aminopirimidina para el tratamiento de infecciones víricas
CN201480009711.3A CN105189468B (zh) 2013-02-21 2014-02-20 用于治疗病毒性感染的2-氨基嘧啶衍生物
BR112015020118-0A BR112015020118B1 (pt) 2013-02-21 2014-02-20 Derivados de 2-aminopirimidina para o tratamento de infecções virais, composição farmacêutica e uso
EA201591524A EA035174B1 (ru) 2013-02-21 2014-02-20 Производные 2-аминопиримидина в качестве модуляторов толл-подобных рецепторов tlr7 и/или tlr8
CA2897587A CA2897587C (en) 2013-02-21 2014-02-20 2-aminopyrimidine derivatives for the treatment of viral infections
SG11201506639XA SG11201506639XA (en) 2013-02-21 2014-02-20 2-aminopyrimidine derivatives for the treatment of viral infections
UAA201508985A UA118751C2 (uk) 2013-02-21 2014-02-20 Похідні 2-амінопіримідину для лікування вірусних інфекцій
NZ709769A NZ709769B2 (en) 2013-02-21 2014-02-20 2-aminopyrimidine derivatives for the treatment of viral infections
MYPI2015702627A MY191389A (en) 2013-02-21 2014-02-20 2-aminopyrimidine derivatives for the treatment of viral infections
DK14705356.5T DK2958900T3 (da) 2013-02-21 2014-02-20 2-aminopyrimidinderivater til behandling af virusinfektioner
KR1020157022968A KR102225233B1 (ko) 2013-02-21 2014-02-20 바이러스 감염의 치료를 위한 2-아미노피리미딘 유도체
EP14705356.5A EP2958900B1 (en) 2013-02-21 2014-02-20 2-aminopyrimidine derivatives for the treatment of viral infections
IL239859A IL239859A0 (en) 2013-02-21 2015-07-09 History of 2-aminopyrimidine for the treatment of viral infections
PH12015501648A PH12015501648A1 (en) 2013-02-21 2015-07-24 2-aminopyrimidine derivatives for the treatment of viral infections
HK16101637.9A HK1213569A1 (zh) 2013-02-21 2016-02-16 用於治療病毒性感染的 -氨基嘧啶衍生物
US15/464,050 US10259793B2 (en) 2013-02-21 2017-03-20 2-aminopyrimidine derivatives for the treatment of viral infections
AU2018204422A AU2018204422A1 (en) 2013-02-21 2018-06-20 2-aminopyrimidine derivatives for the treatment of viral infections
US16/382,816 US10647684B2 (en) 2013-02-21 2019-04-12 2-aminopyrimidine derivatives for the treatment of viral infections

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13156167 2013-02-21
EP13156167.2 2013-02-21

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US14/769,773 A-371-Of-International US9598378B2 (en) 2013-02-21 2014-02-20 2-aminopyrimidine derivatives for the treatment of viral infections
US15/464,050 Continuation US10259793B2 (en) 2013-02-21 2017-03-20 2-aminopyrimidine derivatives for the treatment of viral infections

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WO2014128189A1 true WO2014128189A1 (en) 2014-08-28

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PCT/EP2014/053273 WO2014128189A1 (en) 2013-02-21 2014-02-20 2-aminopyrimidine derivatives for the treatment of viral infections

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US (3) US9598378B2 (da)
EP (1) EP2958900B1 (da)
JP (1) JP6404835B2 (da)
KR (2) KR102225233B1 (da)
CN (1) CN105189468B (da)
AU (2) AU2014220717B2 (da)
BR (1) BR112015020118B1 (da)
CA (1) CA2897587C (da)
CL (1) CL2015002335A1 (da)
DK (1) DK2958900T3 (da)
EA (1) EA035174B1 (da)
ES (1) ES2733361T3 (da)
HK (1) HK1213569A1 (da)
IL (1) IL239859A0 (da)
MX (1) MX367915B (da)
MY (1) MY191389A (da)
PH (1) PH12015501648A1 (da)
SG (1) SG11201506639XA (da)
UA (1) UA118751C2 (da)
WO (1) WO2014128189A1 (da)

Cited By (110)

* Cited by examiner, † Cited by third party
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WO2016141092A1 (en) 2015-03-04 2016-09-09 Gilead Sciences, Inc. Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds
WO2017035230A1 (en) 2015-08-26 2017-03-02 Gilead Sciences, Inc. Deuterated toll-like receptor modulators
WO2017048727A1 (en) 2015-09-15 2017-03-23 Gilead Sciences, Inc. Modulators of toll-like recptors for the treatment of hiv
WO2017106346A2 (en) 2015-12-15 2017-06-22 Gilead Sciences, Inc. Human immunodeficiency virus neutralizing antibodies
WO2017205115A1 (en) 2016-05-27 2017-11-30 Gilead Sciences, Inc. Compounds for the treatment of hepatitis b virus infection
WO2017205078A1 (en) 2016-05-27 2017-11-30 Gilead Sciences, Inc. Methods for treating hepatitis b virus infections using ns5a, ns5b or ns3 inhibitors
WO2018039531A1 (en) 2016-08-26 2018-03-01 Gilead Sciences, Inc. Substituted pyrrolizine compounds and uses thereof
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HK1213569A1 (zh) 2016-07-08
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US20190308940A1 (en) 2019-10-10
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US9598378B2 (en) 2017-03-21
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KR102225233B1 (ko) 2021-03-09
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CN105189468A (zh) 2015-12-23
UA118751C2 (uk) 2019-03-11
KR102300861B1 (ko) 2021-09-10
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US10259793B2 (en) 2019-04-16
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US10647684B2 (en) 2020-05-12
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BR112015020118A2 (pt) 2017-07-18
EA035174B1 (ru) 2020-05-12
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BR112015020118B1 (pt) 2022-02-22
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