WO2014077062A1 - Agent de stérilisation de la peau de type gel transparent - Google Patents

Agent de stérilisation de la peau de type gel transparent Download PDF

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Publication number
WO2014077062A1
WO2014077062A1 PCT/JP2013/077645 JP2013077645W WO2014077062A1 WO 2014077062 A1 WO2014077062 A1 WO 2014077062A1 JP 2013077645 W JP2013077645 W JP 2013077645W WO 2014077062 A1 WO2014077062 A1 WO 2014077062A1
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Prior art keywords
component
mass
transparent gel
content
skin
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PCT/JP2013/077645
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English (en)
Japanese (ja)
Inventor
孝夫 尾杉
友紀 川口
俊輔 廣島
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ライオン株式会社
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Priority to KR1020157006454A priority Critical patent/KR102022747B1/ko
Priority to JP2014546908A priority patent/JP6120872B2/ja
Publication of WO2014077062A1 publication Critical patent/WO2014077062A1/fr
Priority to PH12015500865A priority patent/PH12015500865A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4425—Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/042—Gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A61K8/416—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/26—Optical properties
    • A61K2800/262—Transparent; Translucent

Definitions

  • the present invention relates to a transparent gel-like skin disinfectant.
  • a gel-like disinfectant has been used as a method for easily disinfecting skin such as fingers.
  • a gel-like fungicide a quaternary ammonium salt fungicide represented by benzalkonium chloride is widely used because it has a wide bactericidal spectrum and has an immediate effect.
  • the quaternary ammonium salt disinfectant has a higher disinfecting power as the pH is higher, but the skin irritation becomes stronger.
  • a feeling of use of a gel-like disinfectant the thing which does not sag when picked up and has good elongation is required, and a thickener is blended for this requirement.
  • the quaternary ammonium salt fungicide when used in combination with an anionic thickener such as carboxyvinyl polymer, it forms an anion-cation complex, resulting in white turbidity and poor appearance as well as bactericidal activity. Is greatly reduced, and the immediate effect is impaired.
  • the gel-like disinfectant is also required to have quick drying as a characteristic, and ethanol is blended for this requirement (see, for example, Patent Document 1).
  • the ethanol has an action of suppressing the formation of an anion-cation complex and also has an action of clarifying the gel-like fungicide. Since ethanol has skin irritation, it is desirable to suppress it to less than 40% by mass for the purpose of suppressing skin irritation during continuous use. However, at this concentration, formation of an anion-cation complex is suppressed to make it transparent. There is a problem that can not be.
  • a transparent gel-like skin disinfectant having a transparent appearance, an excellent bactericidal power with little skin irritation, an easy to stretch, a quick-drying property and no stickiness after drying.
  • the current situation is that there is a strong demand for this.
  • the present invention has a transparent gel-like appearance that is transparent in appearance, has excellent sterilizing power with little skin irritation, is easy to stretch, has quick drying properties, and has no stickiness after drying.
  • An object is to provide a skin disinfectant.
  • the present invention is based on the above findings by the present inventors, the transparent gel-like skin disinfectant of the present invention as a means for solving the above problems, (A) at least one quaternary ammonium salt fungicide selected from benzalkonium chloride, benzethonium chloride, and cetylpyridinium chloride; (B) N-coconut oil fatty acid acyl L-arginine ethyl DL-pyrrolidone carboxylate; (C) at least one polyhydric alcohol selected from hexylene glycol, 1,2-pentanediol, 1,6-hexanediol, propylene glycol, sorbitol, and xylitol; (D) ethanol, (E) a carboxyvinyl polymer; The content of the component (B) is 0.01% by mass to 0.3% by mass, the content of the component (D) is 15% by mass to 35% by mass, and the component (A) The mass ratio [(C
  • the conventional problems can be solved, the object can be achieved, the appearance is transparent, the skin irritation is low, the sterilizing power is excellent, the stretch is easy, and the quick-drying property is achieved. It can provide a transparent gel-like skin disinfectant that has an excellent feeling of use, having no stickiness after drying.
  • the transparent gel skin disinfectant of the present invention comprises a quaternary ammonium salt disinfectant (hereinafter sometimes referred to as “component (A)”), N-coconut oil fatty acid acyl L-arginine ethyl DL-pyrrolidone carvone.
  • component (A) quaternary ammonium salt disinfectant
  • component (B) An acid salt
  • component (C) polyhydric alcohol
  • component (D) ethanol
  • component (E) a carboxyvinyl polymer
  • the quaternary ammonium salt fungicide as the component (A) is at least one selected from benzalkonium chloride, benzethonium chloride, and cetylpyridinium chloride.
  • the component (A) is a component having a high bactericidal power against bacteria such as E. coli. Among these, benzalkonium chloride is preferable because it is excellent in sterilizing power, speed of drying, and non-stickiness after drying.
  • the content of the component (A) in the transparent gel skin disinfectant is preferably 0.01% by mass to 0.3% by mass, more preferably 0.02% by mass to 0.2% by mass. If the content of the component (A) is less than 0.01% by mass, the sterilizing power may be insufficient, and if it exceeds 0.3% by mass, white turbidity may occur and the sterilizing power is insufficient. May become difficult to stretch, slow to dry, may cause stickiness after drying, may cause skin irritation, and the like.
  • N-coconut oil fatty acid acyl L-arginine ethyl DL-pyrrolidone carboxylate N-coconut oil fatty acid acyl L-arginine ethyl DL-pyrrolidone carboxylate
  • the N-coconut oil fatty acid acyl L-arginine ethyl DL-pyrrolidone carboxylate as the component (B) is advantageously added to the transparent gel-like skin disinfectant to improve the disinfecting power. It is.
  • a commercial item can be used for the said (B) component. Specific examples of the commercially available product include CAE (registered trademark) (cocoyl arginine ethyl PCA, manufactured by Ajinomoto Healthy Supply Co., Ltd.) under the trade name.
  • the content of the component (B) in the transparent gel-like skin disinfectant is from 0.01% by mass to 0.3% by mass, and from 0.05% by mass to 0.2 mass% is preferable. If the content of the component (B) is less than 0.01% by mass, the sterilizing power may be insufficient. If it exceeds 0.3% by mass, white turbidity may occur and the sterilizing power is insufficient. , Stickiness may occur after drying, and skin irritation may occur.
  • the polyhydric alcohol as the component (C) is at least one selected from hexylene glycol, 1,2-pentanediol, 1,6-hexanediol, propylene glycol, sorbitol, and xylitol.
  • the component (C) is advantageous in that it can improve the transparency of the transparent gel-like skin disinfectant. Among these, hexylene glycol and 1,2-pentanediol are preferable from the viewpoint of excellent transparency and bactericidal activity.
  • the content of the component (C) in the transparent gel skin disinfectant is preferably 5% by mass to 15% by mass and more preferably 8% by mass to 12% by mass from the viewpoint of excellent transparency.
  • the content of the component (C) is less than 5% by mass, white turbidity occurs, sterilizing power may be insufficient, may not be easily stretched, and when it exceeds 15% by mass, drying may be delayed. , Stickiness may occur after drying.
  • Blending ethanol as the component (D) in the transparent gel-like skin disinfectant is advantageous in that the transparency, bactericidal power, and drying speed can be improved.
  • the content of the component (D) in the transparent gel skin disinfectant is excellent in transparency, bactericidal power, easiness of stretching, speed of drying, and less skin irritation. 35% by mass, preferably 20% by mass to 30% by mass. When the content of the component (D) is less than 15% by mass, white turbidity may occur, sterilizing power may be insufficient, it may be difficult to extend, and drying may be slow, and the content exceeds 35% by mass. If it is difficult to stretch, the skin may become rough during continuous use.
  • ⁇ (E) component carboxyvinyl polymer>
  • the viscosity of the component (E) is not particularly limited and may be appropriately selected depending on the intended purpose.
  • An aqueous solution containing 0.2% by mass of the component (E) is neutralized with sodium hydroxide to adjust the pH.
  • the viscosity at 20 ° C. when the viscosity is 7.0 to 7.5 is 2,000 mPa ⁇ s to 30,000 mPa ⁇ s because it is excellent in transparency, speed of drying, and non-stickiness after drying. It is preferably 3,000 mPa ⁇ s to 14,000 mPa ⁇ s. If the viscosity is less than 2,000 mPa ⁇ s, the transparent gel-like skin disinfectant may not be thickened appropriately.
  • the said (E) component may be used individually by 1 type, and may use together 2 or more types from which the said viscosity differs.
  • the viscosity of the component (E) can be measured with a BL type viscometer or a BM type viscometer (manufactured by Tokyo Keiki Co., Ltd.). In the case where the viscosity of the component (E) is 100 mPa ⁇ s or more and less than 10,000 mPa ⁇ s, no. 3 rotor or no. The measurement can be performed under the conditions of 1 rotor at 12 rpm and 20 minutes at 4 ° C. using 4 rotors. When the viscosity of the component (E) is 10,000 mPa ⁇ s or more and less than 50,000 mPa ⁇ s, no. The measurement can be performed under the conditions of 1 rotor at 12 rpm and 20 minutes at 4 ° C. using 4 rotors.
  • a commercially available product can be used as the component (E).
  • Specific examples of the commercially available products include trade names of Carbopol 981 (manufactured by Nihon Lubrizol Co., Ltd.), Carbopol ETD2050 (manufactured by Nihon Lubrizol Co., Ltd.), Hibiswako (registered trademark) 105 (Wako Pure Chemical Industries, Ltd.)
  • the viscosity at 20 ° C. when the pH is adjusted to 7.0 to 7.5 is 3,000 mPa ⁇ s to 14,000 mPa ⁇ s.
  • a 0.2% by mass aqueous solution such as Carbopol 980 (manufactured by Nippon Lubrizol Corporation), Hibiswaco (registered trademark) 104 (manufactured by Wako Pure Chemical Industries, Ltd.), etc. is neutralized with sodium hydroxide to adjust the pH to 7
  • a viscosity at 20 ° C. of 0 to 7.5 is 15,000 mPa ⁇ s to 30,000 mPa ⁇ s. These may be used alone or in combination of two or more.
  • Carbopol 981 (0.2% by mass aqueous solution, pH 7.0 to 7.5, viscosity at 20 ° C .: 4 from the viewpoint of transparency, speed of drying, and non-stickiness after drying. , 000 mPa ⁇ s to 7,500 mPa ⁇ s), Carbopol ETD2050 (0.2 mass% aqueous solution, pH 7.0 to 7.5, viscosity at 20 ° C .: 6,000 mPa ⁇ s to 14,000 mPa ⁇ s) Hibiswaco (registered trademark) 105 (0.2% by mass neutralized solution, viscosity at 20 ° C .: 7,000 mPa ⁇ s to 14,000 mPa ⁇ s) is preferable.
  • the content of the component (E) in the transparent gel-like skin disinfectant is 0.1 because it is excellent in transparency, bactericidal power, ease of stretching, speed of drying, and non-stickiness after drying. % By mass to 0.5% by mass is preferable, and 0.3% by mass to 0.4% by mass is more preferable. When the content of the component (E) is less than 0.1% by mass, it tends to sag and difficult to extend to the skin, and when it exceeds 0.5% by mass, white turbidity occurs and the bactericidal power is poor. The feeling of use such as being sufficient, difficult to stretch, slowing drying, and stickiness after drying may be deteriorated.
  • the mass ratio [(C + D) / (A + B)] of the total content of the component (A) and the component (B) and the total content of the component (C) and the component (D) is transparency, From the viewpoint of excellent drying speed and non-stickiness after drying, it is 100 to 400, preferably 150 to 300. When the mass ratio [(C + D) / (A + B)] is less than 100, white turbidity may occur, and the sterilizing power may be insufficient. When the mass ratio exceeds 400, the sterilizing power and the speed of drying are reduced. Later non-stickiness may be insufficient.
  • the other components in the transparent gel skin disinfectant are not particularly limited as long as the effects of the present invention are not impaired, and can be appropriately selected according to the purpose.
  • a surfactant anionic
  • Surfactants cationic surfactants, amphoteric surfactants, etc.
  • polymer compounds other than the component (E) polymer compounds other than the component (E)
  • moisturizers vitamins, amino acids, anti-inflammatory agents, ultraviolet absorbers, cooling agents, Antioxidant, sequestering agent, animal or plant extract or derivative thereof, colorant, fragrance, deodorant, preservative other than component (A), inclusion compound, solvent other than components (C) and (D) , PH adjusting agents and the like.
  • These may be used alone or in combination of two or more.
  • the pH adjuster is not particularly limited and may be appropriately selected depending on the intended purpose. Triethanolamine, ethylenediamine-N, N, N ′, N ′′ -tetra-2-propanol (quadrol) is preferable. .
  • the content of the other components in the transparent gel skin disinfectant is not particularly limited as long as the effects of the present invention are not impaired, and can be appropriately selected according to the purpose.
  • the pH of the transparent gel-like disinfectant for skin is 6.0 to 8.0 from the viewpoints of transparency, disinfecting power, excellent non-stickiness after drying, and less skin irritation, and 6.5 to 7 .5 is preferred. If the pH is less than 6.0, white turbidity may occur, sterilizing power may be insufficient, it may be difficult to extend, and if it exceeds 8.0, drying may be slow and skin irritation may occur. It may occur.
  • the pH of the transparent gel skin disinfectant can be determined by measuring the pH at 25 ° C. using a pH meter (manufactured by Toa DKK Corporation).
  • the viscosity of the transparent gel skin disinfectant is not particularly limited and may be appropriately selected depending on the intended purpose.
  • the viscosity at 25 ° C. is preferably 300 mPa ⁇ s to 5,000 mPa ⁇ s, 000 mPa ⁇ s to 4,000 mPa ⁇ s is more preferable. If the viscosity of the transparent gel-like skin disinfectant is less than 300 mPa ⁇ s, it tends to sag, so it is difficult to stretch and it may be difficult to rub the skin evenly, and 5,000 mPa ⁇ s.
  • the viscosity of the transparent gel-like skin disinfectant is so high that it is difficult to extend when rubbed into the skin, and the usability may be deteriorated. Moreover, the malfunction that the discharge property from a container worsens may arise.
  • the viscosity of the transparent gel-like skin disinfectant can be adjusted by the component (E).
  • the viscosity of the transparent gel skin disinfectant was measured using a BL type viscometer or a BM type viscometer (manufactured by Tokyo Keiki Co., Ltd.). 3 rotor or no. The measurement can be carried out under the conditions of 1 rotor at 30 rpm at 25 ° C. using 4 rotors.
  • the transmittance (% T) of the transparent gel-like skin disinfectant is not particularly limited and may be appropriately selected depending on the intended purpose, but is preferably 80% T or more from the viewpoint of transparency and disinfecting power. 90% T or more is more preferable. If the transmittance is less than 80% T, white turbidity may occur, a good appearance may not be obtained, and sterilizing power may be reduced.
  • the transmittance (% T) of the transparent gel-like skin disinfectant can be determined by measuring the transmittance at 660 nm using an ultraviolet-visible spectrophotometer (manufactured by JASCO Corporation).
  • the said (E) component is stirred at normal temperature (25 degreeC), stirring purified water. After the uniform dispersion, the component (A), the component (B), the component (C), and the component (D), and if necessary, the other components are added and stirred. It is preferable to dissolve the solution while adjusting the pH to a desired value by adding a pH adjuster.
  • the method for using the transparent gel skin disinfectant is not particularly limited and may be appropriately selected depending on the intended purpose. However, an appropriate amount (preferably about 1 g) is taken to a desired site such as a finger and the skin. A method of rubbing until the whole is dry is preferable.
  • the transparent gel skin disinfectant is particularly preferably used for fingers. In the present invention, “finger” means the entire hand including the palm, the back of the hand, and the fingers of the hand.
  • Examples 1-41 and Comparative Examples 1-14 According to the composition and content shown in Tables 1 to 8 below, the component (E) was uniformly dispersed at 25 ° C. while stirring the purified water with a three-one motor (BL-1200, manufactured by HEIDON), and then (C ) Component or (C ′) component and the component (D) are added and dissolved, then the component (A) and the component (B) are added and dissolved with stirring, and triethanol as a pH adjuster A transparent gel skin disinfectant (transparent gel hand disinfectant) was prepared by adjusting the pH to the values shown in Tables 1 to 8 by adding amine.
  • Escherichia coli NBRC 3972 obtained from Independent Administrative Institution Product Evaluation Infrastructure
  • Escherichia coli NBRC3972 obtained from Independent Administrative Institution Product Evaluation Infrastructure
  • SCD agar medium manufactured by Nippon Pharmaceutical Co., Ltd.
  • the inactivated solution (hereinafter sometimes referred to as “inactivation solution”) was further diluted 100-fold, 1,000-fold, 10,000-fold, and 10-fold serial dilution with SCDLP medium.
  • the measured number of remaining viable bacteria was determined according to the following score, and evaluated based on the following evaluation criteria based on the average value of the scores.
  • cfu is a colony forming unit.
  • Example 42 According to the composition and blending amount shown below, (E) component was uniformly dispersed at 25 ° C. while stirring purified water with a three-one motor (BL-1200, manufactured by HEIDON). Add component (D) and dissolve, add component (A), component (B), and other additional components to dissolve with stirring, add pH adjuster to adjust pH to 7. By adjusting to 5, the transparent gel-like hand disinfectant of Example 42 was prepared. With respect to the transparent gel-like hand germicide of Example 42, “transparency”, “bactericidal power”, “easiness to stretch”, “speed of drying” were performed in the same manner as in Examples 1-41 and Comparative Examples 1-14. ”,“ No stickiness after drying ”, and“ skin irritation ”.
  • composition and blending amount Benzalkonium chloride [component (A)] ⁇ ⁇ ⁇ 0.05% N-coconut oil fatty acid acyl L-arginine ethyl DL-pyrrolidone carboxylate [component (B)] 0.1% Hexylene glycol [component (C)] ...
  • Example 43 In Example 42, the transparent gel-like hand germicide of Example 43 was prepared in the same manner as in Example 42, except that the composition and blending amount were changed to the composition and blending amount shown below. With respect to the transparent gel-like hand germicide of Example 43, “transparency”, “bactericidal power”, “easiness to stretch”, “speed of drying” were performed in the same manner as in Examples 1-41 and Comparative Examples 1-14. And “no stickiness after drying”. [Composition and blending amount] Benzethonium chloride [component (A)] ...
  • Examples of the aspect of the present invention include the following. ⁇ 1> (A) at least one quaternary ammonium salt fungicide selected from benzalkonium chloride, benzethonium chloride, and cetylpyridinium chloride; (B) N-coconut oil fatty acid acyl L-arginine ethyl DL-pyrrolidone carboxylate; (C) at least one polyhydric alcohol selected from hexylene glycol, 1,2-pentanediol, 1,6-hexanediol, propylene glycol, sorbitol, and xylitol; (D) ethanol, (E) a carboxyvinyl polymer; Containing The content of the component (B) is 0.01% by mass to 0.3% by mass, the content of the component (D) is 15% by mass to 35% by mass, The mass ratio [(C + D) / (A + B)] of the total content of the component (A) and the component
  • the transparent gel-like skin disinfectant characterized by having a pH of 6.0 to 8.0 and a transparent appearance.
  • the content of component (A) is 0.01% by mass to 0.3% by mass
  • the content of component (C) is 5% by mass to 15% by mass
  • the content of component (E) Is the transparent gel-like skin disinfectant according to ⁇ 1>, in which is 0.1% by mass to 0.5% by mass.
  • the mass ratio [(C + D) / (A + B)] of the total content of the components (A) and (B) and the total content of the components (C) and (D) is 150 to 300.
  • ⁇ 4> The transparent gel-like skin disinfectant according to any one of ⁇ 1> to ⁇ 3>, wherein the component (C) is at least one of hexylene glycol and 1,2-pentanediol.
  • ⁇ 5> The transparent gel-like skin disinfectant according to any one of ⁇ 1> to ⁇ 4>, wherein the pH is 6.5 to 7.5.
  • the transparent gel-like skin disinfectant of the present invention has an excellent use in that the appearance is transparent, the skin irritation is excellent, the disinfecting power is excellent, it is easy to stretch, it has a quick drying property, and there is no stickiness after drying.
  • employees in food-related industries such as meat and seafood processing, restaurant kitchens, doctors, nurses and caregivers in hospitals, health centers, etc. It can be suitably used for sterilization of skin such as a finger of a patient.

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne un agent de stérilisation de la peau de type gel transparent comprenant (A) un agent stérilisant sel d'ammonium quaternaire spécifique, (B) un DL-pyrrolidone-carboxylate de N-acyle d'acide gras d'huile de palme de L-arginine-éthyle, (C) un alcool polyhydrique spécifique, (D) de l'éthanol, et (E) un polymère carboxy-vinylique ; la teneur en constituant (B) étant de 0,01 à 0,3 % en masse, la teneur en constituant (D) étant de 15 à 35 % en masse, le rapport massique de la teneur totale en constituants (C) et (D) sur la teneur totale en constituants (A) et (B) [c'est-à-dire (C+D)/(A+B)] étant de 100 à 400, la valeur du pH étant située dans la plage allant de 6,0 à 8,0, et l'agent de stérilisation étant d'apparence transparente.
PCT/JP2013/077645 2012-11-16 2013-10-10 Agent de stérilisation de la peau de type gel transparent WO2014077062A1 (fr)

Priority Applications (3)

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KR1020157006454A KR102022747B1 (ko) 2012-11-16 2013-10-10 투명 겔형상 피부용 살균제
JP2014546908A JP6120872B2 (ja) 2012-11-16 2013-10-10 透明ゲル状皮膚用殺菌剤
PH12015500865A PH12015500865A1 (en) 2012-11-16 2015-04-17 Transparent gel-like skin-sterilizing agent

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JP2012252401 2012-11-16
JP2012-252401 2012-11-16

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WO2014077062A1 true WO2014077062A1 (fr) 2014-05-22

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JP (1) JP6120872B2 (fr)
KR (1) KR102022747B1 (fr)
MY (1) MY171722A (fr)
PH (1) PH12015500865A1 (fr)
WO (1) WO2014077062A1 (fr)

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JPH08157322A (ja) * 1994-12-06 1996-06-18 Rashiinu Kagaku Kk 薬事法指定の酸化防止剤ないしは防腐剤を含まない化粧品
JP2003079530A (ja) * 2001-09-12 2003-03-18 Uni Charm Corp ウエットティッシュ
JP2011153089A (ja) * 2010-01-27 2011-08-11 Lion Corp ゲル状手指殺菌剤

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JP4034016B2 (ja) * 1999-09-06 2008-01-16 株式会社ナリス化粧品 化粧料
JP4247597B2 (ja) * 2002-08-29 2009-04-02 ライオン株式会社 外用剤
JP4072458B2 (ja) * 2003-05-14 2008-04-09 日本エヌエスシー株式会社 化粧料用水性組成物及びそれを含んで成る化粧料
JP4091498B2 (ja) * 2003-08-26 2008-05-28 株式会社マンダム 防腐殺菌剤並びに該防腐殺菌剤を配合した化粧料、医薬品及び食品
JP2006070025A (ja) * 2004-08-06 2006-03-16 Eisai Co Ltd 防腐防黴剤含有組成物
JP5557991B2 (ja) * 2008-08-13 2014-07-23 ライオン株式会社 液体口腔用組成物
KR20110087663A (ko) * 2010-01-27 2011-08-03 라이온 가부시키가이샤 겔상 수지 살균제

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08157322A (ja) * 1994-12-06 1996-06-18 Rashiinu Kagaku Kk 薬事法指定の酸化防止剤ないしは防腐剤を含まない化粧品
JP2003079530A (ja) * 2001-09-12 2003-03-18 Uni Charm Corp ウエットティッシュ
JP2011153089A (ja) * 2010-01-27 2011-08-11 Lion Corp ゲル状手指殺菌剤

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JP6120872B2 (ja) 2017-04-26
MY171722A (en) 2019-10-24
PH12015500865A1 (en) 2015-06-22
KR102022747B1 (ko) 2019-09-18
KR20150085807A (ko) 2015-07-24
JPWO2014077062A1 (ja) 2017-01-05

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