WO2014073450A1 - 酒酔い軽減剤 - Google Patents

酒酔い軽減剤 Download PDF

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Publication number
WO2014073450A1
WO2014073450A1 PCT/JP2013/079581 JP2013079581W WO2014073450A1 WO 2014073450 A1 WO2014073450 A1 WO 2014073450A1 JP 2013079581 W JP2013079581 W JP 2013079581W WO 2014073450 A1 WO2014073450 A1 WO 2014073450A1
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WO
WIPO (PCT)
Prior art keywords
tomato
alcohol
drunkenness
soluble component
insoluble
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PCT/JP2013/079581
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English (en)
French (fr)
Japanese (ja)
Inventor
大嶋　俊二
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アサヒグループホールディングス株式会社
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Application filed by アサヒグループホールディングス株式会社 filed Critical アサヒグループホールディングス株式会社
Publication of WO2014073450A1 publication Critical patent/WO2014073450A1/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes

Definitions

  • the present invention relates to a drunkenness alleviating agent, and more particularly to a drunky alleviating agent that reduces drought or drunkness due to a large amount of drinking.
  • Alcohol taken into the body by drinking is metabolized by mitochondria in hepatocytes and decomposed into acetaldehyde with strong hepatotoxicity, and then acetaldehyde is rapidly decomposed into acetic acid.
  • Acetic acid is released from the liver into the blood, enters the TCA circuit as a source of energy for peripheral tissues, and is eventually broken down into carbon dioxide and water.
  • a drunk reducing agent An edible composition for reducing the absorption of alcohol by a human or animal body is called a drunk reducing agent.
  • Many drunkenness alleviating agents are effective based on blood alcohol and acetaldehyde concentration data. There are few examples of using drunk reducing agents to examine the reduction of drought or drunkness due to the effect of actually ingesting a large amount of alcohol.
  • Patent Document 1 can help restore the functional structure of the liver, accelerate the elimination of alcohol from the blood and tissues, and prevent neuropsychological disorders associated with chronic alcoholism and related syndromes.
  • a mitigating metadoxine composition is disclosed.
  • Non-patent document 1 states that ethanol was administered to mice at 2 g / kg and the increase in blood acetaldehyde concentration was suppressed, but the blood ethanol concentration was about 1.6 mg / ml, which was mild to moderate. However, the behavior of animals is not examined, and there is no mention of the effect of reducing the effects of alcohol.
  • Non-patent Document 2 the improvement effect on sickness caused by alcohol administration was investigated for the type vulnerable to alcohol, and stomach discomfort and nausea were reduced, but the alcohol dose was about 0.5 g / kg,
  • the blood ethanol concentration is also between 0.4 and 0.8 mg / ml, and the evaluation is based on the amount of alcohol consumed that exhibits mild wrinkles, and the improvement effect over strength wrinkles has not been studied.
  • Non-Patent Document 3 when tomato juice and alcohol are ingested at the same time, there is a possibility that the intoxication will be moderated and the intoxication after drinking may be accelerated, and as a cause thereof, There is a tendency to increase the activity of enzymes that metabolize alcohol and acetaldehyde in vivo, and in particular, it is described that the activity of LDH in the liver is significantly increased.
  • the present invention solves the above-mentioned conventional problems, and an object of the present invention is to provide a drunk reducing agent capable of reducing the degree of drought or drunkness when drinking a large amount of alcohol.
  • the present invention provides the use of an insoluble component of tomato in the preparation of a drunk reducing agent.
  • the insoluble component of the tomato is a residue obtained by removing a water-soluble component from the tomato raw material.
  • the insoluble component of the tomato is a residue obtained by removing a water-soluble component and a fat-soluble component from the tomato raw material.
  • the tomato material is at least one selected from the group consisting of tomato fruit, dried tomato powder and squeezed rice cake after squeezing the tomato fruit.
  • the removal of the fat-soluble component from the tomato raw material is performed by extraction using at least one selected from the group consisting of ethanol and ethyl acetate.
  • the present invention also provides a drunk reducing agent containing an insoluble component of tomato.
  • the drunkenness reducing agent of the present invention can reduce drought or drunkness when drinking a large amount of alcohol. Moreover, the drunkenness reducing agent of the present invention can be easily and safely ingested as an edible composition on a daily basis.
  • the tomato referred to in the present invention is a variety of tomatoes conventionally used for food.
  • Tomatoes include, for example, so-called pink tomatoes and red tomatoes.
  • Tomato is a fruit that can be eaten raw.
  • the tomato fruit in a ready-to-eat state is preferably a ripe fruit.
  • tomato varieties include “Momotaro” (trade name), First Tomato, Mini Tomato, Plum Tomato, “Kinko Hime” (trade name), Cindy Sweet, Cindy Orange, Reward, Sunroad, Shurei, Palto, Raw tomatoes such as My Rock, Rinka 409, Renaissance, Reika, Reiko and Rokusanmaru, San Marzano, Chico No. 3, Kurikoma, Furikoma, High Peel, Kagome 77, KGM952, and KGM993 etc.
  • Processing tomatoes, Aichi Examples include raw food processing tomatoes such as tomatoes, June pink and Ponterosa.
  • Insoluble means insoluble in liquid.
  • the liquid includes water and an organic solvent.
  • An organic solvent here means the organic solvent which can melt
  • Specific examples of organic solvents include alcohol solvents, ethanol, propanol, isopropanol, butanol, isobutanol, etc., ester solvents, ethyl acetate, ethyl acetoacetate, isoamyl formate, methyl cinnamate, etc., ketone solvents
  • ether solvents such as acetophenone, ionone, methyl- ⁇ -naphthyl ketone, and ketones include 1,8-cineol, ethyl panillin, vanillin, ethers, phenol ethers, and the like.
  • Preferred organic solvents are ethanol and ethyl acetate.
  • Insoluble ingredients include water-insoluble dietary fiber.
  • Dietary fiber refers to indigestible components that are not digested by digestive enzymes in the human body among the components of food.
  • the insoluble component of tomato is a residue obtained by removing the water-soluble component from the tomato raw material. It is preferable that the insoluble component of tomato is obtained by removing the fat-soluble component.
  • tomato materials include tomato fruit, dried tomato powder, and tomato squeezed strawberries. The tomato fruit may be after heating.
  • tomato raw material is preferably tomato pomace.
  • Tomato squeezed rice cake is a by-product in the production process of juice and the like, and is a residue obtained by squeezing tomato and then filtering and removing liquid components such as fruit juice.
  • Tomato raw materials are washed, crushed and squeezed as necessary to remove as much liquid components as possible. However, it is not necessary to completely remove the liquid component. Thereafter, the tomato material from which the liquid component has been removed is subjected to a step of removing the water-soluble component and, if necessary, a step of removing the fat-soluble component. Either the step of removing the water-soluble component or the step of removing the fat-soluble component may be performed first. However, from the viewpoint of work efficiency, it is preferable to perform the step of removing the water-soluble component first.
  • the step of removing the water-soluble component from the tomato raw material is, for example, putting the tomato raw material from which liquid components such as tomato pomace or dried tomato are removed as much as possible into water and stirring, and then the liquid part containing the water-soluble component By separating from the solid part. Separation of the liquid part and the solid part is performed by a commonly used method such as filtration and centrifugation.
  • the step of removing the fat-soluble component from the tomato raw material is, for example, putting the tomato raw material from which liquid components such as tomato squeezed rice cake or dried tomato are removed as much as possible into the above organic solvent and stirring, and the liquid part containing the fat-soluble component By separating from the solid part. Separation of the liquid part and the solid part is performed by a commonly used method such as filtration and centrifugation.
  • the insoluble component of the tomato obtained can be used as an anti-drunk agent.
  • Tomato is a food and the insoluble components of tomato are harmless. Therefore, when the insoluble component of tomato is to be ingested by humans as an anti-drunk agent, the intake amount may be determined appropriately according to the purpose.
  • the insoluble component of tomato is ingested in an amount of about 0.1 g / kg or more based on body weight. If the intake of insoluble components in tomato is less than 0.1 g / kg based on body weight, the effect of reducing drought or drunkness when drinking a large amount of alcohol is low. Note that 0.1 g / kg, which is a lower limit example of the intake, is 6 g when converted to the intake of a human body weight of 60 kg.
  • the anti-drunk agent of the present invention may be taken before, during or after drinking.
  • the anti-drunk agent of the present invention is excellent in effect and is characterized by exhibiting the effect of reducing drought or drunkenness even when ingested after drinking.
  • an additive such as saccharides and excipients, or a liquid component may be used in combination with the insoluble component of tomato as long as the effects of the present invention are not impaired.
  • the anti-drunk agent of the present invention may be prepared in the form of food or beverage.
  • a form called a supplement is preferable, and a form such as a tablet or granule is preferable.
  • As a beverage it is common to adjust to a form such as a drink. You may mix with alcoholic beverages.
  • These foods or beverages may be produced by a conventional method. For example, it can be produced by the following method.
  • additives such as excipients and sweeteners.
  • additives such as excipients, sweeteners, lubricants are added and mixed, and then compressed into tablets using a rotary tableting machine, single-punch tableting machine, etc. Can be manufactured.
  • excipients include starch (corn starch, potato starch, wheat starch, rice starch, etc.), lactose colloidal silica, crystalline cellulose, anhydrous silicic acid, anhydrous calcium phosphate, precipitated calcium carbonate, calcium silicate, light anhydrous silicic acid. Hydrous silicon dioxide, silicon dioxide, aluminum oxide, magnesium carbonate, precipitated calcium carbonate, crystalline cellulose, synthetic aluminum silicate, magnesium silicate, magnesium metasilicate aluminate, dextrin, carmellose calcium and the like. These carriers may be used alone or in combination of two or more.
  • the crystalline cellulose includes microcrystalline cellulose.
  • sweetener examples include sugar, sugar alcohol, glucose, fructose, galactose, mannose, lactose, maltose, sucrose, sucrose (including purified sucrose), trehalose, mannitol, sorbitol, maltitol, aspartame, erythritol. Xylitol and the like, and these may be used alone or in combination of two or more.
  • the lubricant examples include magnesium stearate, calcium stearate, sodium stearyl fumarate, stearic acid, talc, sucrose fatty acid ester, glycerin fatty acid ester, polyethylene glycol, vegetable oil and the like.
  • the lubricant may be added by any of the method of adding to the granule before tableting and mixing, or the method of adhering directly to the punch or die during tableting.
  • Rats were forcibly intragastricly administered with 4 g / kg of ethanol, a dose that reached the blood ethanol concentration (Tsukamoto et al., Medicina, 2005), which is from the high-strength period in humans to the drunk period. Thirty minutes later, the test substance was dissolved or suspended in water and administered into the forced stomach, and the subsequent locomotor activity was examined over time. As a test object, the material shown below was employ
  • Example 1 Tomato dry powder (variety: Renaissance, manufactured by Ishikawa Farm Co., Ltd.) 2.367g of whole raw tomato powder is added to 40ml of distilled water, vortexed vigorously for 2 minutes, centrifuged (3000rpm, 10 minutes), The clear aqueous fraction and residue were separated. 10 ml of distilled water was added to the obtained tomato residue to make a suspension. A suspension of 16.9 ml / kg was administered by gavage. The weight of the residue obtained by this treatment is 15.7%, which is equal to the dietary fiber content in the tomato dry powder, and its dosage is 0.63 g / kg corresponding to 4 g / kg of tomato dry powder. It was.
  • Example 1 The aqueous fraction separated from the tomato residue by the operation of Example 1 was concentrated by distillation under reduced pressure until the volume reached 10 ml. A concentrated solution of 16.9 ml / kg was administered by gavage.
  • Example 2 The same operation as in Example 1 was performed to obtain a tomato residue.
  • the obtained tomato residue was put in 500 ml of ethanol and stirred for 1 hour, and then the filtered residue was next put in 500 ml of ethyl acetate, stirred for 5 hours and then filtered again to dry the residue overnight.
  • tomato residue obtained by extraction was obtained.
  • 10 ml of distilled water was added to the obtained tomato residue to make a suspension.
  • a suspension of 16.9 ml / kg was administered by gavage. The dosage was 0.63 g / kg corresponding to 4 g / kg of tomato dry powder.
  • FIG. 1 shows the results of Example 1, Comparative Example 1 and Example 2. From this result, it was confirmed that the tomato residue has an effect of reducing the degree of drought or drunkness, the effect is enhanced by the extracted tomato residue, and is hardly observed in the aqueous fraction of tomato. .
  • Pectin and cellulose were forcibly administered intragastrically at 16.9 ml / kg to a solution suspended in distilled water to 3.74% to 0.63 g / kg.
  • Example 3 In order to examine the effective amount of tomato residue, the extraction-treated tomato residue was produced in the same manner as in Example 2, and the dosage was 0.3 g / kg, 0.1 g / kg, 0.05 g / kg, and 0. Spontaneous momentum of the rat at 025 g / kg was examined.
  • Example 3 The results of Example 3 are shown in FIG. It was confirmed that the effect of reducing the degree of drunkenness or drunkness by the tomato residue subjected to the extraction treatment is exhibited at a dose of 0.1 g / kg or more.
  • the ethanol concentration in blood by administration of 4 g / kg of alcohol is around 3 mg / ml, which is the result of drinking about 5 large beer bottles in terms of humans.
  • a human with a body weight of 60 kg it is considered that if 6 g or more of the extracted tomato residue is ingested, the effect of reducing drought or drunkness can be obtained.
  • the drunk prevention agent of the present invention can be used as food or beverage.

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
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PCT/JP2013/079581 2012-11-09 2013-10-31 酒酔い軽減剤 WO2014073450A1 (ja)

Applications Claiming Priority (2)

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JP2012-247246 2012-11-09
JP2012247246A JP6012415B2 (ja) 2012-11-09 2012-11-09 酒酔い軽減剤

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Publication number Priority date Publication date Assignee Title
JP6573756B2 (ja) * 2014-08-22 2019-09-11 アサヒグループホールディングス株式会社 トマト含有飲食品
JP2016086715A (ja) * 2014-10-31 2016-05-23 アサヒグループホールディングス株式会社 ニンジン由来成分含有飲食品

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JP2007246478A (ja) * 2006-03-17 2007-09-27 Kagome Co Ltd アセトアルデヒド代謝促進剤

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JPS5424940A (en) * 1977-07-26 1979-02-24 Kagome Kk Production of carotinoid containing substance for coloring food
IL146496A0 (en) * 2001-11-14 2002-07-25 Lycored Natural Prod Ind Ltd Carotenoid composition and method for protecting skin
ES2322757T3 (es) * 2003-08-21 2009-06-26 Nestec S.A. Concentrado natural de licopeno y procedimiento de obtencion.
KR101092197B1 (ko) * 2009-11-11 2011-12-13 남종현 토마토 전초 추출물을 유효성분으로 하는 지방간 개선용 식품조성물

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Publication number Priority date Publication date Assignee Title
JP2007246478A (ja) * 2006-03-17 2007-09-27 Kagome Co Ltd アセトアルデヒド代謝促進剤

Non-Patent Citations (3)

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Title
ASAHI GROUP: "Kagome Kyodo Kenkyu Tomato ga Inshugo no Kecchu Alcohol Nodo o Teika saseru Koto o Hito de Kakunin -Yoi no Mawari ga Yuruyaka ni nari, Inshugo no Yoizame mo Hayamaru Kanosei ga Shisa", NEWS RELEASE, KAGOME CO., LTD., 25 May 2012 (2012-05-25), KAGOME CO., LTD, Retrieved from the Internet <URL:http://www.kagome.co.jp/Co./news/2012/05/001371.html> [retrieved on 20131206] *
EVANS, RANDOLPH W. ET AL.: "Alcohol hangover headache.", HEADACHE, vol. 47, 2007, pages 277 - 279 *
KURCER MEHMET ALI ET AL.: "Effect of lycopene on caspase-3 enzyme activation in liver of methanol-intoxicated rats: comparison with fomepizole", JOURNAL OF MEDICINAL FOOD, vol. 13, no. 4, 2010, pages 985 - 991 *

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