WO2014059757A1 - 新型钌络合物及制备甲醇和二醇的方法 - Google Patents
新型钌络合物及制备甲醇和二醇的方法 Download PDFInfo
- Publication number
- WO2014059757A1 WO2014059757A1 PCT/CN2013/073095 CN2013073095W WO2014059757A1 WO 2014059757 A1 WO2014059757 A1 WO 2014059757A1 CN 2013073095 W CN2013073095 W CN 2013073095W WO 2014059757 A1 WO2014059757 A1 WO 2014059757A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- group
- ruthenium complex
- aryl
- independently selected
- methanol
- Prior art date
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 title claims abstract description 285
- 239000012327 Ruthenium complex Substances 0.000 title claims abstract description 104
- 238000000034 method Methods 0.000 title claims abstract description 60
- 150000002009 diols Chemical class 0.000 title claims abstract description 52
- 239000001257 hydrogen Substances 0.000 claims abstract description 76
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 76
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 67
- 238000005984 hydrogenation reaction Methods 0.000 claims abstract description 43
- 150000005676 cyclic carbonates Chemical class 0.000 claims abstract description 33
- -1 amido diphosphine Chemical compound 0.000 claims abstract description 28
- OKKJLVBELUTLKV-MZCSYVLQSA-N Deuterated methanol Chemical compound [2H]OC([2H])([2H])[2H] OKKJLVBELUTLKV-MZCSYVLQSA-N 0.000 claims abstract description 22
- 229920000515 polycarbonate Polymers 0.000 claims abstract description 20
- 239000004417 polycarbonate Substances 0.000 claims abstract description 20
- 239000003446 ligand Substances 0.000 claims abstract description 11
- 239000003960 organic solvent Substances 0.000 claims abstract description 8
- 229910052707 ruthenium Inorganic materials 0.000 claims abstract description 8
- 239000012298 atmosphere Substances 0.000 claims abstract description 6
- 238000006243 chemical reaction Methods 0.000 claims description 135
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical group C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 72
- 125000003118 aryl group Chemical group 0.000 claims description 65
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Chemical group C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 36
- 239000003054 catalyst Substances 0.000 claims description 30
- 239000002585 base Substances 0.000 claims description 27
- 125000002723 alicyclic group Chemical group 0.000 claims description 24
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical group CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 22
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 17
- 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 claims description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 14
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical group C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 claims description 14
- 150000002431 hydrogen Chemical class 0.000 claims description 11
- 150000001875 compounds Chemical class 0.000 claims description 10
- 125000004122 cyclic group Chemical group 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 10
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims description 7
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical group [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 claims description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 7
- 125000004432 carbon atom Chemical group C* 0.000 claims description 7
- 229910002091 carbon monoxide Inorganic materials 0.000 claims description 7
- 239000001307 helium Substances 0.000 claims description 7
- 229910052734 helium Inorganic materials 0.000 claims description 7
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 claims description 7
- 150000004678 hydrides Chemical class 0.000 claims description 7
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims description 7
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Chemical group COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 7
- 230000035484 reaction time Effects 0.000 claims description 7
- 229910052703 rhodium Inorganic materials 0.000 claims description 7
- 125000003277 amino group Chemical group 0.000 claims description 6
- 125000006612 decyloxy group Chemical group 0.000 claims description 6
- 229910052757 nitrogen Inorganic materials 0.000 claims description 6
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 6
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 claims description 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 5
- 125000003107 substituted aryl group Chemical group 0.000 claims description 5
- 229910052783 alkali metal Inorganic materials 0.000 claims description 4
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 4
- 125000001041 indolyl group Chemical group 0.000 claims description 4
- 108010007425 oligomycin sensitivity conferring protein Proteins 0.000 claims description 4
- 230000009467 reduction Effects 0.000 claims description 4
- 230000009471 action Effects 0.000 claims description 3
- 229910000288 alkali metal carbonate Inorganic materials 0.000 claims description 3
- 150000008041 alkali metal carbonates Chemical class 0.000 claims description 3
- 150000008044 alkali metal hydroxides Chemical class 0.000 claims description 3
- 229910052741 iridium Inorganic materials 0.000 claims description 2
- 229910052742 iron Inorganic materials 0.000 claims description 2
- 229910052759 nickel Inorganic materials 0.000 claims description 2
- 229910052762 osmium Inorganic materials 0.000 claims description 2
- 229910052763 palladium Inorganic materials 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
- 229910052697 platinum Inorganic materials 0.000 claims description 2
- 229910052723 transition metal Inorganic materials 0.000 claims description 2
- 150000003623 transition metal compounds Chemical class 0.000 claims description 2
- 150000003624 transition metals Chemical class 0.000 claims description 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 238000002360 preparation method Methods 0.000 abstract description 16
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 abstract description 8
- 238000006722 reduction reaction Methods 0.000 abstract description 7
- 239000003513 alkali Substances 0.000 abstract description 2
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 abstract 1
- VURFVHCLMJOLKN-UHFFFAOYSA-N Diphosphine Natural products PP VURFVHCLMJOLKN-UHFFFAOYSA-N 0.000 abstract 1
- 229910052805 deuterium Inorganic materials 0.000 abstract 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 63
- URLKBWYHVLBVBO-UHFFFAOYSA-N Para-Xylene Chemical group CC1=CC=C(C)C=C1 URLKBWYHVLBVBO-UHFFFAOYSA-N 0.000 description 62
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 40
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 30
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical group [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 28
- 238000004817 gas chromatography Methods 0.000 description 27
- RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 description 25
- 239000005457 ice water Substances 0.000 description 23
- 230000008569 process Effects 0.000 description 22
- 239000001569 carbon dioxide Substances 0.000 description 20
- 229910002092 carbon dioxide Inorganic materials 0.000 description 20
- KMTRUDSVKNLOMY-UHFFFAOYSA-N Ethylene carbonate Chemical compound O=C1OCCO1 KMTRUDSVKNLOMY-UHFFFAOYSA-N 0.000 description 16
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 9
- 238000009903 catalytic hydrogenation reaction Methods 0.000 description 8
- 239000007789 gas Substances 0.000 description 8
- 239000002994 raw material Substances 0.000 description 8
- 230000003197 catalytic effect Effects 0.000 description 7
- 125000001424 substituent group Chemical group 0.000 description 7
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- IEJIGPNLZYLLBP-UHFFFAOYSA-N dimethyl carbonate Chemical compound COC(=O)OC IEJIGPNLZYLLBP-UHFFFAOYSA-N 0.000 description 6
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 6
- 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 description 6
- 239000010948 rhodium Substances 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 5
- 238000005481 NMR spectroscopy Methods 0.000 description 5
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 5
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 description 5
- 150000003303 ruthenium Chemical class 0.000 description 5
- 125000003396 thiol group Chemical group [H]S* 0.000 description 5
- 229910052727 yttrium Inorganic materials 0.000 description 5
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 4
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 4
- 150000001298 alcohols Chemical class 0.000 description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 4
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- 239000000446 fuel Substances 0.000 description 4
- 150000002334 glycols Chemical class 0.000 description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 4
- QPJVMBTYPHYUOC-UHFFFAOYSA-N methyl benzoate Chemical compound COC(=O)C1=CC=CC=C1 QPJVMBTYPHYUOC-UHFFFAOYSA-N 0.000 description 4
- 230000007935 neutral effect Effects 0.000 description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 4
- 239000000376 reactant Substances 0.000 description 4
- MFRIHAYPQRLWNB-UHFFFAOYSA-N sodium tert-butoxide Chemical compound [Na+].CC(C)(C)[O-] MFRIHAYPQRLWNB-UHFFFAOYSA-N 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 3
- 239000004593 Epoxy Substances 0.000 description 3
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 150000004696 coordination complex Chemical class 0.000 description 3
- ROORDVPLFPIABK-UHFFFAOYSA-N diphenyl carbonate Chemical compound C=1C=CC=CC=1OC(=O)OC1=CC=CC=C1 ROORDVPLFPIABK-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000007062 hydrolysis Effects 0.000 description 3
- 238000006460 hydrolysis reaction Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 238000005160 1H NMR spectroscopy Methods 0.000 description 2
- JWUJQDFVADABEY-UHFFFAOYSA-N 2-methyltetrahydrofuran Chemical compound CC1CCCO1 JWUJQDFVADABEY-UHFFFAOYSA-N 0.000 description 2
- MHAHSWCGEPZNLA-UHFFFAOYSA-N 4,4,5,5-tetramethyl-1,3-dioxan-2-one Chemical compound CC1(OC(OCC1(C)C)=O)C MHAHSWCGEPZNLA-UHFFFAOYSA-N 0.000 description 2
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- 0 CP1(C2c3ccccc3)*2(*(CC=*)c2ccccc2)NCC1 Chemical compound CP1(C2c3ccccc3)*2(*(CC=*)c2ccccc2)NCC1 0.000 description 2
- 239000005977 Ethylene Substances 0.000 description 2
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000006555 catalytic reaction Methods 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 239000012043 crude product Substances 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 239000002815 homogeneous catalyst Substances 0.000 description 2
- 239000011261 inert gas Substances 0.000 description 2
- 229940095102 methyl benzoate Drugs 0.000 description 2
- 239000003345 natural gas Substances 0.000 description 2
- 239000012074 organic phase Substances 0.000 description 2
- 239000003208 petroleum Substances 0.000 description 2
- 150000002989 phenols Chemical class 0.000 description 2
- 229920000379 polypropylene carbonate Polymers 0.000 description 2
- 229910000027 potassium carbonate Inorganic materials 0.000 description 2
- WQKGAJDYBZOFSR-UHFFFAOYSA-N potassium;propan-2-olate Chemical compound [K+].CC(C)[O-] WQKGAJDYBZOFSR-UHFFFAOYSA-N 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- JJKUOVDAMCXQFK-UHFFFAOYSA-H ruthenium(3+);tricarbonate Chemical compound [Ru+3].[Ru+3].[O-]C([O-])=O.[O-]C([O-])=O.[O-]C([O-])=O JJKUOVDAMCXQFK-UHFFFAOYSA-H 0.000 description 2
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 2
- WBQTXTBONIWRGK-UHFFFAOYSA-N sodium;propan-2-olate Chemical compound [Na+].CC(C)[O-] WBQTXTBONIWRGK-UHFFFAOYSA-N 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000008096 xylene Substances 0.000 description 2
- VDFVNEFVBPFDSB-UHFFFAOYSA-N 1,3-dioxane Chemical compound C1COCOC1 VDFVNEFVBPFDSB-UHFFFAOYSA-N 0.000 description 1
- VYXHVRARDIDEHS-UHFFFAOYSA-N 1,5-cyclooctadiene Chemical compound C1CC=CCCC=C1 VYXHVRARDIDEHS-UHFFFAOYSA-N 0.000 description 1
- 239000004912 1,5-cyclooctadiene Substances 0.000 description 1
- XFDQLDNQZFOAFK-UHFFFAOYSA-N 2-benzoyloxyethyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCCOC(=O)C1=CC=CC=C1 XFDQLDNQZFOAFK-UHFFFAOYSA-N 0.000 description 1
- 125000003229 2-methylhexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- DYPGZYRIXGVXRD-UHFFFAOYSA-N 4,4,5,5-tetramethyl-1,3-dioxolan-2-one Chemical compound CC1(C)OC(=O)OC1(C)C DYPGZYRIXGVXRD-UHFFFAOYSA-N 0.000 description 1
- CBMUUDZXMOBDFC-UHFFFAOYSA-N 4,4-dimethyl-1,3-dioxan-2-one Chemical compound CC1(C)CCOC(=O)O1 CBMUUDZXMOBDFC-UHFFFAOYSA-N 0.000 description 1
- ZUBVBRAWCGZYMQ-UHFFFAOYSA-N 4,5-dimethyl-1,3-dioxan-2-one Chemical compound CC1COC(=O)OC1C ZUBVBRAWCGZYMQ-UHFFFAOYSA-N 0.000 description 1
- KMNNJQRGOSPCPB-UHFFFAOYSA-N 4-benzyl-1,3-dioxan-2-one Chemical compound C(C1=CC=CC=C1)C1OC(OCC1)=O KMNNJQRGOSPCPB-UHFFFAOYSA-N 0.000 description 1
- OFGBTQWRUSFGQQ-UHFFFAOYSA-N 4-butyl-1,3-dioxan-2-one Chemical compound CCCCC1CCOC(=O)O1 OFGBTQWRUSFGQQ-UHFFFAOYSA-N 0.000 description 1
- UYACRRWRRSZGFO-UHFFFAOYSA-N 4-ethyl-4h-1,3-dioxin-2-one Chemical compound CCC1OC(=O)OC=C1 UYACRRWRRSZGFO-UHFFFAOYSA-N 0.000 description 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 description 1
- HVLXXXCDBMIEPZ-UHFFFAOYSA-N 5-(phenylmethoxymethyl)-1,3-dioxan-2-one Chemical compound C1OC(=O)OCC1COCC1=CC=CC=C1 HVLXXXCDBMIEPZ-UHFFFAOYSA-N 0.000 description 1
- TYLLPALZFPIYFL-UHFFFAOYSA-N 5-phenyl-1,3-dioxan-2-one Chemical compound C1(=CC=CC=C1)C1COC(OC1)=O TYLLPALZFPIYFL-UHFFFAOYSA-N 0.000 description 1
- BISUFDNSWDVFNB-UHFFFAOYSA-K C(C=C)(=O)[O-].[Ru+3].C(C=C)(=O)[O-].C(C=C)(=O)[O-] Chemical compound C(C=C)(=O)[O-].[Ru+3].C(C=C)(=O)[O-].C(C=C)(=O)[O-] BISUFDNSWDVFNB-UHFFFAOYSA-K 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 125000002015 acyclic group Chemical group 0.000 description 1
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- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 150000001721 carbon Chemical group 0.000 description 1
- ZVENKBGRIGHMRG-UHFFFAOYSA-M carbon monoxide chloro(hydrido)ruthenium triphenylphosphane Chemical compound [C-]#[O+].[H][Ru]Cl.c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1 ZVENKBGRIGHMRG-UHFFFAOYSA-M 0.000 description 1
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- 125000005843 halogen group Chemical group 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000002638 heterogeneous catalyst Substances 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 239000012442 inert solvent Substances 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 238000010667 large scale reaction Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- SJYNFBVQFBRSIB-UHFFFAOYSA-N norbornadiene Chemical compound C1=CC2C=CC1C2 SJYNFBVQFBRSIB-UHFFFAOYSA-N 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
- 150000002923 oximes Chemical class 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 1
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004344 phenylpropyl group Chemical group 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 125000005493 quinolyl group Chemical group 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 238000005809 transesterification reaction Methods 0.000 description 1
- VWQVUPCCIRVNHF-UHFFFAOYSA-N yttrium atom Chemical compound [Y] VWQVUPCCIRVNHF-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
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- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/18—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms
- B01J31/189—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms containing both nitrogen and phosphorus as complexing atoms, including e.g. phosphino moieties, in one at least bidentate or bridging ligand
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- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
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- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
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- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
- B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
- B01J31/2409—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring with more than one complexing phosphine-P atom
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- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
- B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
- B01J31/2442—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring comprising condensed ring systems
- B01J31/2461—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring comprising condensed ring systems and phosphine-P atoms as ring members in the condensed ring system or in a further ring
- B01J31/2471—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring comprising condensed ring systems and phosphine-P atoms as ring members in the condensed ring system or in a further ring with more than one complexing phosphine-P atom
- B01J31/2476—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring comprising condensed ring systems and phosphine-P atoms as ring members in the condensed ring system or in a further ring with more than one complexing phosphine-P atom comprising aliphatic or saturated rings
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- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
- C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
- C07C37/0555—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group being esterified hydroxy groups
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- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
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- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0046—Ruthenium compounds
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- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0046—Ruthenium compounds
- C07F15/0053—Ruthenium compounds without a metal-carbon linkage
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- C07F19/00—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00
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- B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
- B01J2231/60—Reduction reactions, e.g. hydrogenation
- B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
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- B01J2231/60—Reduction reactions, e.g. hydrogenation
- B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
- B01J2231/641—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
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- B01J2231/60—Reduction reactions, e.g. hydrogenation
- B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
- B01J2231/641—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
- B01J2231/643—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes of R2C=O or R2C=NR (R= C, H)
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- B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
- B01J2531/02—Compositional aspects of complexes used, e.g. polynuclearity
- B01J2531/0238—Complexes comprising multidentate ligands, i.e. more than 2 ionic or coordinative bonds from the central metal to the ligand, the latter having at least two donor atoms, e.g. N, O, S, P
- B01J2531/0241—Rigid ligands, e.g. extended sp2-carbon frameworks or geminal di- or trisubstitution
- B01J2531/0247—Tripodal ligands, e.g. comprising the tris(pyrazolyl)borate skeleton, "tpz", neutral analogues thereof by CH/BH exchange or anionic analogues of the latter by exchange of one of the pyrazolyl groups for an anionic complexing group such as carboxylate or -R-Cp
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- B01J2531/02—Compositional aspects of complexes used, e.g. polynuclearity
- B01J2531/0238—Complexes comprising multidentate ligands, i.e. more than 2 ionic or coordinative bonds from the central metal to the ligand, the latter having at least two donor atoms, e.g. N, O, S, P
- B01J2531/0258—Flexible ligands, e.g. mainly sp3-carbon framework as exemplified by the "tedicyp" ligand, i.e. cis-cis-cis-1,2,3,4-tetrakis(diphenylphosphinomethyl)cyclopentane
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- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Definitions
- This invention relates to the field of organic synthesis. More specifically, the present invention relates to a process for preparing methanol and a diol using a ruthenium complex as a catalyst. Background technique
- Methanol is the simplest, safest and most easily stored liquid oxygenated hydrocarbon fuel. It is also an important chemical substitute for petroleum. It can be used to synthesize various products such as methanol to olefin (MTO) and methanol to propylene. (MTP), methanol to aromatic hydrocarbons (MTA), and the like.
- MTO methanol to olefin
- MTP methanol to propylene.
- MTA methanol to aromatic hydrocarbons
- methanol is an effective solution to the energy problems caused by the decreasing oil, coal and natural gas resources in the post-oil and gas era [Olah, GA, Geoppert, A. & Surya Prakash, GK Beyond Oil and Gas : The Methanol Economy, Wiley-VCH, 2006.].
- the production scale of methanol has grown rapidly (in 2010, only 38 million tons of methanol was produced in China), but these production processes use coal, natural gas or petroleum as raw materials, facing the problem that fossil fuel resources are depleted and
- glycol compounds are also important fuels and industrial raw materials.
- 1,2-ethanediol is an extremely important chemical raw material and solvent, in polyester fiber, film, resin and engine coolant.
- Conventional processes produce 1,2-ethanediol by hydrolysis of ethylene oxime, but the production of various by-products directly affects the quality of the product.
- Shell Oil Company of the United Kingdom has developed a new process called OMEGA, which first forms a cyclic ethylene carbonate by the action of epoxy oxime and carbon dioxide, which is hydrolyzed by the catalyst to obtain 1,2- Ethylene glycol and emits carbon dioxide [http: ⁇ en.wikipedia.org/wiki/OMEGA- process#cite-note-0.].
- OMEGA a new process
- 1,2-ethanediol is 99% selective through the OMEGA process, one drawback of this process is that carbon dioxide is not effectively utilized and is returned to the environment after the reaction is complete.
- Carbon dioxide is both an environmentally friendly greenhouse gas and an inexhaustible, inexpensive, safe and renewable carbon resource [Carbon Dioxide as Chemical Feedstock, (Ed. : M. Aresta), Wiley-VCH, Weinheim, 2010)].
- the production of methanol by catalytic hydrogenation of carbon dioxide is an important path to achieve methanol economy.
- this reaction is thermodynamically feasible, direct reduction of carbon dioxide is often very difficult due to the high degree of inertness of the carbon-oxygen double bonds, which is a major challenge in industry and academia.
- a small amount of heterogeneous catalyst system has been reported for this reaction, but the common drawback is that the reaction needs not only under the harsh high temperature and high pressure (250 ° C, 50 atm) conditions, but also the efficiency and selectivity.
- the present invention provides a process for the preparation of methanol and a diol, which comprises: reacting a cyclic carbonate or polycarbonate under the action of a catalyst under a hydrogen atmosphere to obtain methanol and Glycol,
- R 1 , R 2 , R 3 , R 4 , R 5 , R 6 may be independently selected from hydrogen, a thiol group of Ci C ⁇ , an aryl group of C 4 to C 24 , an arylsulfonyl group of C 5 to C 25 , (C Guang C 8 )-OR 7 , -(C Guang C 8 )-SR 8 or -( C ⁇ -NR 9 ! ⁇ ;
- R 5 and R 6 may also be independently selected from cycloalkyl groups of 4 to 10 carbon atoms;
- R 7 , R 8 , R 9 and R 1Q are independently selected from the group consisting of a fluorenyl group of a do, a C 4 ⁇ C 24 aryl group or a C 5 ⁇ C 25 aryl fluorenyl group, and R 9 and R 1Q may also be linked to each other.
- the nitrogen atoms together form a cyclic amine group;
- R 1 and R 3 may be bonded to an alicyclic group or to an aromatic ring;
- R 1 and R 5 , R 3 and R 6 may be bonded to an alicyclic group or an aromatic ring;
- R r , R 2 , R 3 , R 4 , R 5 , and R 6 ' may be independently selected from the group consisting of hydrogen, C ⁇ thiol, C 4 to C 24 aryl, C 5 to C 25 aryl Base group, -(C widely C 8 )-OR 7 ', -(C ⁇ C ⁇ -SR 8 ' or -( C ⁇ -NWR 10 ';
- R 5 ', R 6 ' may also be independently selected from cycloalkyl groups of 4 to 10 carbon atoms;
- R 7 ', R 8 ', R 9 ', R 1Q ' are independently selected from the group consisting of CH), a C 4 to C 24 aryl group or a C 5 to C 25 aryl fluorenyl group, R 9 ', R 1Q ' may also be bonded to form a cyclic amine group together with a nitrogen atom;
- R 1 'and R 3 ' may be linked to an alicyclic group or to an aromatic ring;
- R 1 'and R 5 ', R 3 ' and R 6 ' may be bonded to an alicyclic group or an aromatic ring.
- the catalyst is a Group VIIIB transition metal compound.
- the Group VIIIB transition metal is selected from the group consisting of Fe, Co, Ni, Ru, Rh,
- the method comprises the following reaction in the presence of an organic solvent and a base:
- X is carbon monoxide, triphenylphosphine, pyridine, tetrahydrofuran or dimethyl sulfoxide;
- Y, ⁇ independently selected from: hydride, hydroxide, chloride, bromide, iodide, and ⁇ 4 _, BH 3 CN ⁇ BH (EtV, BH( ⁇ ec-Bu) 3 ", A1H 4 - or AlH 2 (OCH 2 CH 2 CH 3 ) 2 - ;
- R 0 is H
- R r , R 2 "indolyl group independently selected from do, C 3 -C 1Q cyclodecyl, C 4 -C 24 aryl or adamantyl, wherein the aryl includes unsubstituted or substituted Aryl;
- R 3 ", R 4 “, R 5 “, R 6 “, R 7 “, 8” independently selected from the group consisting of hydrogen, Cn), a C 3 -C 1Q cyclodecyl group, CH) alkoxy or An aryl group of C 4 to C 36 ;
- R 3 "and R 7 “ and R 4 “and R 8 " may be bonded to an alicyclic group or to an aromatic ring; when n ⁇ 1, R 3 "and R 5 “, R 4 “ and R 6 “, R 5 “ and R 7 “ and R 6 “and R 8 " may be bonded to an alicyclic group or an aromatic ring.
- the ruthenium complex V is as shown in structural formula la: In other words,
- the molar ratio of the cyclic carbonate or polycarbonate to the ruthenium complex is from 100 to 1,000,000:1.
- the molar ratio of the cyclic carbonate or polycarbonate to the ruthenium complex is
- the base is an alkali metal salt of an alcohol, an alkali metal carbonate, or an alkali metal hydroxide.
- the base is potassium t-butoxide, sodium t-butoxide, potassium isopropoxide, sodium isopropoxide, sodium ethoxide, or potassium carbonate, sodium carbonate, sodium hydroxide or potassium hydroxide.
- the base is potassium t-butoxide.
- the rhodium complex catalyzes the hydrogenation of a cyclic carbonate under neutral conditions to provide methanol and the corresponding diol.
- the molar ratio of the base to the ruthenium complex is from 1 to 100:1.
- the molar ratio of the base to the ruthenium complex is from 1 to 20: 1, more preferably from 1 to 5:1. In a further preferred embodiment, the molar ratio of the base to the ruthenium complex is 1:1.
- the temperature of the reaction is from 60 to 180 °C.
- the temperature of the reaction is from 80 to 150 ° C, more preferably from 80 to 140 ° C.
- reaction time of the reaction is from 0.1 to 1000 hours.
- reaction time is from 0.5 to 100 hours, more preferably from 1 to 72 hours.
- hydrogen pressure in the reaction is from 1 to 100 atmospheres.
- the hydrogen pressure in the reaction is from 5 to 60 atmospheres, more preferably from 50 atmospheres.
- the inert solvent is tetrahydrofuran, 2-methyltetrahydrofuran, dioxane, ethylene glycol dimethyl ether, tert-butyl methyl ether, benzene, toluene, xylene, methanol, ethanol, isopropyl alcohol, Tert-butanol.
- the organic solvent is tetrahydrofuran, dioxane or toluene.
- the present invention provides a ruthenium complex of the formula V,
- X is carbon monoxide, triphenylphosphine, pyridine, tetrahydrofuran or dimethyl sulfoxide;
- Y, ⁇ independently selected from: hydride, hydroxide, chloride, bromide, iodide and ⁇ 4 _ BH 3 CN ⁇ BH(Et) 3 -, BH( ⁇ ec-Bu) 3 ", A1H 4 ⁇ AlH 2 (OCH 2 CH 2 CH 3 ) 2 -;
- the ruthenium complex is used to hydrogenate a reduced carbonate.
- the ruthenium complex is used to hydrogenate a reduced cyclic or polymeric carbonate to produce Methanol and diol are obtained.
- the present invention provides a process for the preparation of deuterated methanol and deuterated diol, which process uses the helium D 2 instead of hydrogen to effect the process of the second aspect of the invention, thereby obtaining deuterated methanol and Modern generation
- the present invention provides a process for producing an alcohol, which comprises subjecting a carbonate to hydrogenation reduction in an organic solvent in the presence of a ruthenium complex (V) and a base to obtain an alcohol, wherein
- the ruthenium complex is as shown in formula V
- X is carbon monoxide, triphenylphosphine, pyridine, tetrahydrofuran or dimethyl sulfoxide;
- Y, ⁇ independently selected from: hydride, hydroxide, chloride, bromide, iodide and ⁇ 4 _, BH 3 CN ⁇ BH(Et) 3 -, BH( ⁇ ec-Bu) 3 ", A1H 4 ⁇ AlH 2 (OCH 2 CH 2 CH 3 ) 2 -;
- n 0 ⁇ 3;
- R 0 is H
- R v R 2 "independently selected from CH", fluorenyl, C 3 -C 1Q cyclodecyl, C 4 -C 24 aryl, adamantyl, wherein the aryl is unsubstituted or substituted base;
- R 3 ,,, R 4 ,,,, R 5 ,,, R 6 ,,, R 7 ,, R 8 is independently selected from hydrogen, decyl of do, C 3 -C 1Q cyclodecyl, do of a decyloxy group, an aryl group of C 4 to C 36 ;
- R 3 "and R 7 " and R 4 "and R 8 " may be bonded to an alicyclic group or an aromatic ring;
- the inventors unexpectedly discovered that a complex formed by ruthenium and a tridentate aminobisphosphorus PNP clamp ligand was used as a catalyst, and hydrogenation was used as a hydrogen source to hydrogenate a cyclic carbonate. Methanol and 1,2-ethanediol and derivatives thereof can be obtained with high efficiency and high selectivity, thereby indirectly achieving chemical conversion of carbon dioxide to methanol.
- the inventors have also for the first time discovered that the use of the catalyst of the present invention enables efficient catalytic hydrogenation of polycarbonates to methanol and glycols, thereby recovering diols and methanol from spent polycarbonate materials.
- the catalyst of the present invention can efficiently catalyze the deuteration of a cyclic carbonate, thereby enabling the preparation of deuterated methanol and deuterated diol.
- the present invention has been completed on this basis.
- decyl of "do” means a straight or branched fluorenyl group containing up to 10 carbon atoms, such as methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl Base, pentyl, isopentyl, neopentyl, hexyl, tert-hexyl, heptyl, isoheptyl, octyl and isooctyl.
- "dooxy” of do denotes a thiol group, as defined above, attached through an oxygen atom, such as methoxy, ethoxy, propoxy, butoxy, and the like.
- aryl means a substituent having a property of an aromatic ring structure such as a phenyl group, a furyl group, a thienyl group, a pyridyl group, a quinolyl group or a fluorenyl group.
- the aryl group includes an unsubstituted or substituted aryl group, wherein the substituent means having one or more substituents, and representative substituents include, but are not limited to, the above-mentioned mercapto group, decyloxy group and halogen atom. And nitro and so on.
- aryl groups include aryl groups with electron donating and/or electron withdrawing substituents such as p-tolyl, p-methoxyphenyl, p-chlorophenyl and the like.
- aryl fluorenyl means a substituent in which an aryl group and a fluorenyl group are bonded, such as a phenylmethyl group, a phenylethyl group, a phenylpropyl group or the like.
- diol is used interchangeably with “dihydroxy compound” and refers to a compound having two hydroxyl groups at the end. It will be understood by one of ordinary skill in the art that in particular embodiments, the term may include compounds such as alcohols, phenols, and the like, depending on the particular group attached to the hydroxyl group.
- the "diol" of the present invention may optionally contain hydroxyl groups at other positions in addition to the two hydroxyl groups at the terminus which may be formed by catalytic cracking by the process of the invention. Conversion efficiency
- conversion efficiency refers to the percentage of the amount of reactant that has been consumed in a chemical reaction to the total amount of the reactant initially added.
- conversion efficiency or efficiency rate as used herein refers to the percentage of the amount of reactant that has been consumed in a chemical reaction to the total amount of the reactant initially added.
- the hydrogenation reaction of a cyclic carbonate is exemplified, and the conversion is expressed by the number of moles of the cyclic carbonate consumed and the initial percentage under a certain reaction time under a specific condition.
- conversion number refers to the ratio of the number of moles of reactants that have been converted to the number of moles of catalyst over a period of time.
- the hydrogenation reaction of a cyclic carbonate is exemplified, and the number of conversions is a ratio of the number of moles of the cyclic carbonate consumed to the number of moles of the catalyst in a certain reaction time under a specific condition.
- the conversion and the number of conversions are calculated by gas chromatography using para-xylene as an internal standard by measuring the carbonate using a standard curve method; that is, using p-xylene as an internal standard, for carbonic acid
- the ester, methanol and diol were plotted on the gas chromatogram as the ratio of the peak area to the peak area ratio of p-xylene.
- the content of carbonate, methanol and diol in the reaction system is determined by measuring the ratio of the peak area in the reaction system.
- carbonate as used herein includes linear carbonates (i.e., acyclic, non-polymeric carbonates such as dimethyl carbonate), cyclic carbonates, polycarbonates.
- linear carbonates i.e., acyclic, non-polymeric carbonates such as dimethyl carbonate
- cyclic carbonates i.e., acyclic, non-polymeric carbonates such as dimethyl carbonate
- polycarbonates i.e., polycarbonates.
- the cyclic carbonates and polycarbonates of the present invention are as shown in Formulas I and II, respectively:
- RR 2 , R 3 , R 4 , R 5 and R 6 are independently hydrogen, a sulfhydryl group of CC ⁇ , an aryl group of C 4 to C 24 , an arylsulfonyl group of C 5 to C 25 , -(C ⁇ C ⁇ -OR 7 -(C Guang C 8 )-SR 8 or -(C Guang C 8 )-NR 9 R 10 ;
- R 5 and R 6 may also independently be a cyclic substituent of 4 to 10 carbon atoms
- R 7 , R 8 , R 9 , R 1Q are independently selected from the group consisting of CH), an aryl group of C 4 to C 24 , or an aryl group of C 5 to C 25 Hospital base
- R 9 , R 1Q may also be bonded to form a cyclic amine group together with a nitrogen atom;
- R 1 and R 3 may be bonded to an alicyclic group or to an aromatic ring;
- R 1 and R 5 , R 3 and R 6 may be bonded to an alicyclic group or an aromatic ring;
- R, R 2 , R 3 , R 4 , R 5 , and R 6 ' may be independently selected from the group consisting of hydrogen, C! C ⁇ fluorenyl, C 4 to C 24 aryl, C 5 to C 25 Aryl fluorenyl, -(CrC ⁇ -OR 7 ⁇ -(C ⁇ C ⁇ -SR 8 ' or -(CrC ⁇ -NR 9 '! ⁇ ';
- R 5 ', R 6 ' may also be independently selected from cycloalkyl groups of 4 to 10 carbon atoms;
- R 7 , R 8 , R 9 , R 1Q ' are independently selected from CH) fluorenyl, C 4 to C 24 aryl, or C 5 to C 25 aryl fluorenyl, R 9 ' , R 1Q ' may also be linked to form a cyclic amine group together with a nitrogen atom;
- R 1 'and R 3 ' may be linked to an alicyclic group or an aromatic ring;
- R 1 'and R 5 ', R 3 ' and R 6 ' may be bonded to an alicyclic group or an aromatic ring.
- cyclic carbonates are an important class of chemical raw materials and solvents which can be produced by large-scale reaction of carbon dioxide and epoxy compounds.
- the process for preparing ethylene carbonate from carbon dioxide and ethylene oxime has been industrialized.
- Catalytic hydrogenation of cyclic carbonates can achieve indirect efficient use of carbon dioxide, as well as important fuels and industrial raw materials such as methanol and 1,2-ethanediol, which have great application value.
- the catalyst of the present invention is a ruthenium complex having the general structure V.
- the ruthenium complex comprises a tridentate aminobisphosphorus ligand L of the general structure VI.
- X is independently selected from the group consisting of carbon monoxide, triphenylphosphine, pyridine, tetrahydrofuran, and dimethyl sulfoxide.
- Y, Y independently selected from hydride, hydroxide, chloride, bromide, iodide, and BH 4 _, BH 3 CN_, BH(Et) 3 -, BH( ⁇ ec-Bu) 3 A1H 4 ⁇ or AlH 2 (OCH 2 CH 2 CH 3 ) 2 -.
- Y and Y can be the same or different.
- n 0 ⁇ 3;
- R 0 is H
- R v R 2 "indolyl group independently selected from do, C 3 -C 1Q cyclodecyl group, C 4 -C 24 aryl group, or adamantyl group;
- R 3 ,,, R 4 ,,,, R 5 ,,, R 6 ,,, R 7 ,, R 8 is independently selected from hydrogen, decyl of do, C 3 -C 1Q cyclodecyl, do of a decyloxy group, or an aryl group of C 4 to C 36 ;
- R 3 "and R 7 " and R 4 "and R 8 " may be bonded to an alicyclic group or an aromatic ring;
- the catalyst of the present invention i.e., the ruthenium complex
- the catalyst of the present invention is as shown in the following structural formula la-le:
- the rhodium catalyst of the present invention can be prepared by the following method:
- a ruthenium metal precursor such as [RuHCi(C())(PPh 3 ) 3 ], [RuH 2 (CO), under an inert gas such as a nitrogen or argon atmosphere at 60 to 120 ° C PP 3 ) 3 ], RsiCi 2 (PPh 3 ) 3 , [RuCl 2 (C 6 H 6 )] 2 , [RuHCi(PPh 3 ) 3 ], Ru(DMSO) 4 Cl 2 , [Ru(cod)Cl 2 ], [Ru(nM)Ci 2 ] is prepared by reacting 2 equivalents of tridentate aminobisphosphorus ligand in a solvent for 0, 5 20 h.
- DMSO represents dimethyl sulfoxide
- cod represents 1,5-cyclooctadiene
- nbd represents norbornadiene.
- the catalyst of the present invention that is, a ruthenium complex
- the ester, polymeric carbonate and linear carbonate are hydrogenated to methanol and the corresponding other alcohol or diol to indirectly convert carbon dioxide to methanol and provide the corresponding diol.
- the hydrogenation-reduction carbonate of the ruthenium complex of the present invention not only has high conversion efficiency, but also has excellent economy and ease of handling. Preparation of methanol by the invention
- the present invention provides an original process for the catalytic hydrogenation of methanol and 1,2-ethanediol and other glycol derivatives.
- the method of the invention adopts a complex formed by ruthenium and a ligand as a catalyst, and hydrogenation-reduction reaction of a cyclic carbonate or polycarbonate with hydrogen as a hydrogen source, and methanol and 1,2-B are obtained with high efficiency and high selectivity. Glycols and their derivatives.
- the process of the invention is: a cyclic carbonate (formula I) or polycarbonate in the presence of a ruthenium complex (V) and a base in an organic solvent under a hydrogen atmosphere.
- Formula II The following hydrogenation reduction reaction is carried out to obtain methanol and the corresponding diol III or IV,
- the ruthenium complex represented by the following structural formula la-le is used in the above reaction:
- the base which can be used in the process of the present invention includes alkali metal salts of alcohols such as potassium t-butoxide, sodium t-butoxide, potassium isopropoxide, sodium isopropoxide, sodium ethoxide, alkali metal carbonates such as potassium carbonate and carbonic acid.
- alkali metal salts of alcohols such as potassium t-butoxide, sodium t-butoxide, potassium isopropoxide, sodium isopropoxide, sodium ethoxide, alkali metal carbonates such as potassium carbonate and carbonic acid.
- Sodium an alkali metal hydroxide such as sodium hydroxide or potassium hydroxide.
- an alkali metal salt of an alcohol is used as a base, and more preferably potassium t-butoxide is a base.
- the molar ratio of the cyclic carbonate or polycarbonate to the ruthenium complex is 100-1000000: 1. In a preferred embodiment, the molar ratio of the cyclic carbonate or polycarbonate to the ruthenium complex is from 1000 to 100,000, more preferably from 10,000 to 100,000 to 100,000.
- the molar ratio of the base to the ruthenium complex is from 1 to 100:1. In a preferred embodiment, the molar ratio of the base to the ruthenium complex is from 1 to 20: 1, more preferably from 1 to 5:1. In a further preferred embodiment, the molar ratio of the base to the ruthenium complex is 1:1.
- the temperature of the reaction may be from 60 to 180 °C. In a preferred embodiment, the temperature of the reaction is from 80 to 150 ° C, more preferably from 80 to 140 ° C.
- the reaction time of the reaction is from 0.1 to 1000 h. In a preferred embodiment, the reaction is carried out for a period of from 0.5 to 100 hours, more preferably from 1 to 72 hours.
- the hydrogen pressure in the reaction is from 1 to 100 atmospheres. In a preferred embodiment, the hydrogen pressure in the reaction is from 5 to 60 atmospheres, more preferably from 10 to 50 atmospheres.
- Organic solvents usable in the process of the invention include tetrahydrofuran, 2-methyltetrahydrofuran, dioxane, ethylene glycol dimethyl ether, tert-butyl methyl ether, benzene, toluene, xylene, methanol, ethanol, isopropanol, tert-butyl Alcohol, etc.
- the process of the present invention utilizes ethers such as tetrahydrofuran and dioxane, and solvents such as toluene.
- the hydrogenation reaction can be carried out by using a linear carbonate, that is, a non-cyclic, non-polymeric carbonate as a raw material.
- a linear carbonate that is, a non-cyclic, non-polymeric carbonate
- Methanol and other monohydric alcohols are prepared.
- the inventors According to the process for producing methanol and diol according to the present invention, the inventors also reduced the cyclic carbonate to form deuterated methanol and deuterated diol by using helium instead of hydrogen.
- the method of the present invention can catalytically hydrogenate a cyclic carbonate to form methanol and a diol, thereby achieving an indirect conversion of carbon dioxide to methanol.
- the resulting diol is also an extremely valuable fuel and chemical industry raw material;
- the process of the invention can catalytically hydrogenate polycarbonate materials to methanol and diol from waste polycarbonate materials with high efficiency and high selectivity. , with higher atomicity than polycarbonate hydrolysis Economical
- the method of the invention does not generate waste materials and meets the technical requirements for sustainable development of economic and environmental protection
- the method of the invention is simple and convenient to operate, can be carried out under mild conditions, and has low cost;
- the reaction kettle was heated and stirred in an oil bath at 140 ° C for 0.5 hour. After the reactor was cooled in an ice water bath for 1.5 hours, excess hydrogen was slowly released.
- gas chromatography using the standard curve method, that is, using p-xylene as an internal standard, the ratio of the peak area ratio of the peak area to the paraxylene on the gas chromatograph of carbonate, methanol and diol is made, The ratio of the peak area in the reaction system was measured to determine the mass of the carbonate, methanol and glycol contained in the reaction mixture after the end of the reaction. The conversion of the reaction was determined to be >99%. Methanol and ethylene glycol The yield was 99%.
- Example 7 Hydrogenation of ethylene carbonate catalyzed by ruthenium complex la.
- a ruthenium complex la (1.7 mg, 0.00286) was added to a 125 mL autoclave.
- Methyl), potassium tert-butoxide (0.32 mg, 0.00286 mmol) in tetrahydrofuran (5 mL), tetrahydrofuran (15 mL), ethylene carbonate (2.52 g, 28.6 mmol).
- the autoclave was sealed and removed from the glove box.
- the hydrogen gas was charged at 50 atm.
- the reaction kettle was heated and stirred in an oil bath at 140 ° C for 48 hours.
- Example 8 Hydrogenation of ethylene carbonate catalyzed by ruthenium complex la to prepare methanol and ethylene glycol in gloves
- ruthenium complex la (0.17 mg, 0.000286 mmol), potassium tert-butoxide (0.032 mg, 0.000286 mmol) in tetrahydrofuran (2 mL), tetrahydrofuran (18 mL), Ethylene carbonate (2.52 g, 28.6 mmol).
- the autoclave was sealed, it was taken out from the glove box and filled with hydrogen at 60 atm.
- the reaction kettle was heated and stirred in an oil bath at 140 ° C for 72 hours.
- Example 9 ruthenium complex lb catalyzed Hydrogenation of ethylene carbonate to prepare methanol and ethylene glycol
- a ruthenium complex lb (13.5 mg, 0.0286 mmol), potassium t-butoxide (3.2 mg, 0.0286 mmol) was added to a 125 mL autoclave.
- Example 10 Hydrogenation of ethylene carbonate catalyzed by ruthenium complex Id
- ruthenium complex Id (18.0 mg) was added to a 125 mL autoclave. , 0.0286 mmol), potassium tert-butoxide (3.2 mg, 0.0286 mmol), tetrahydrofuran (20 m L), ethylene carbonate (2.52 g, 28.6 mmol)
- the autoclave was sealed and taken out of the glove box, and charged with hydrogen at 50 atm.
- the reaction kettle was heated and stirred in an oil bath at 140 ° C for 0.5 hour. After the reactor was cooled in an ice water bath for 1.5 hours, excess hydrogen was slowly released. Using p-xylene as an internal standard, the conversion of the reaction was determined by gas chromatography to be 76%. The yields of methanol and ethylene glycol were 48% and 76%, respectively.
- Example 11 Hydrogenation of propylene carbonate catalyzed by ruthenium complex la
- a ruthenium complex la (3.5 mg, 0.057 mmol), potassium t-butoxide (0.5 mg, 0.057 mmol), tetrahydrofuran (20 mL), propylene carbonate (2.92 g) was added to a 125 mL autoclave. , 28.6 mmol).
- the autoclave was sealed and taken out of the glove box and filled with hydrogen at 50 atm.
- the reaction kettle was stirred and heated in an oil bath at 140 ° C for 10 hours. After the reactor was cooled in an ice water bath for 1.5 hours, excess hydrogen was slowly released.
- a ruthenium complex la (8.7 mg, 0.0143 mmol), potassium t-butoxide (1.6 mg, 0.0143 mmol), tetrahydrofuran (20 mL), 4-ethyl-1 was added to a 125 mL autoclave. , 3-dioxin-2-one (3.32 g, 28.6 mmol).
- the autoclave was sealed and taken out of the glove box and filled with hydrogen at 50 atm.
- the reaction kettle was stirred and heated in an oil bath at 140 ° C for 10 hours. After the reaction vessel was cooled in an ice water bath for 1.5 hours, excess hydrogen was slowly allowed to be discharged.
- Example 13 Hydrogenation reaction of ruthenium complex catalyzed la-catalyzed 4-butyl-1,3-dioxan-2-one
- a ruthenium complex la (8.7 mg, 0.0143 mmol), potassium t-butoxide (1.6 mg, 0.0143 mmol), tetrahydrofuran (20 mL), 4-butyl-1 was added to a 125 mL autoclave. , 3-dioxin-2-one (4.12 g, 28.6 mmol).
- the autoclave was sealed and taken out of the glove box and filled with hydrogen at 50 atm.
- the reaction kettle was stirred and heated in an oil bath at 140 ° C for 4 hours. After the reaction vessel was cooled in an ice water bath for 1.5 hours, excess hydrogen was slowly allowed to be discharged.
- Example 14 Hydrogenation reaction of a ruthenium complex catalyzed by a ruthenium complex of 5-phenyl-1,3-dioxan-2-one
- a ruthenium complex la (8.7 mg, 0.0143 mmol), potassium t-butoxide (1.6 mg, 0.0143 mmol), tetrahydrofuran (20 mL), 4-phenyl-1 was added to a 125 mL autoclave.
- 3-dioxin-2-one (4.69 g, 28.6 mmol) o
- the reaction kettle was stirred and heated in an oil bath at 140 ° C for 4 hours. After cooling the reaction kettle in an ice water bath for 1.5 hours, slowly put it Excess hydrogen is lost.
- Example 15 Hydrogenation of a cyclic carbonate, 4-benzyl-1,3-dioxan-2-one catalyzed by ruthenium complex la
- a ruthenium complex la (8.7 mg, 0.0143 mmol), potassium t-butoxide (1.6 mg, 0.0143 mmol), tetrahydrofuran (20 mL), 4-benzyl-1 was added to a 125 mL autoclave. , 3-dioxin-2-one (5.09 g, 28.6 mmol).
- the autoclave was sealed and taken out of the glove box and filled with hydrogen at 50 atm.
- the reaction kettle was stirred and heated in an oil bath at 140 ° C for 4 hours. After the reaction vessel was cooled in an ice water bath for 1.5 hours, excess hydrogen was slowly allowed to be discharged.
- a ruthenium complex la (8.7 mg, 0.0143 mmol), potassium t-butoxide (1.6 mg, 0.0143 mmol), tetrahydrofuran (20 mL), 4-methoxyl was added to a 125 mL autoclave.
- Base-1,3-dioxan-2-one (3.78 g, 28.6 mmol) o
- the autoclave was sealed and removed from the glove box and filled with hydrogen at 50 atm.
- the reaction kettle was stirred and heated in an oil bath at 140 ° C for 4 hours. After the reaction vessel was cooled in an ice water bath for 1.5 hours, excess hydrogen was slowly allowed to be discharged.
- Example 17 Rhodium complex catalyzed hydrogenation of cyclic catalyzed 5-benzyloxymethyl-1,3-dioxan-2-one
- a ruthenium complex la (8.7 mg, 0.0143 mmol), potassium t-butoxide (1.6 mg, 0.0143 mmol), tetrahydrofuran (20 mL), 4-benzyloxymethyl was added to a 125 mL autoclave.
- Base-1,3-dioxan-2-one (5.94 g, 28.6 mmol) o
- the autoclave was sealed and removed from the glove box and filled with hydrogen at 50 atm.
- the reaction kettle was stirred and heated in an oil bath at 140 ° C for 4 hours. After the reactor was cooled in an ice water bath for 1.5 hours, excess hydrogen was slowly released.
- Example 18 Hydrogen of a cyclic carbonate, 4,5-dimethyl-1,3-dioxan-2-one catalyzed by ruthenium complex la Chemical reaction
- a ruthenium complex la (8.7 mg, 0.0143 mmol), potassium t-butoxide (1.6 mg, 0.0143 mmol), tetrahydrofuran (20 mL), 4,5-dimethyl was added to a 125 mL autoclave.
- Base-1,3-dioxan-2-one (3.32 g, 28.6 mmol) o
- the autoclave was sealed and removed from the glove box and filled with hydrogen at 50 atm.
- the reaction vessel was stirred and heated in an oil bath at 140 ° C for 10 hours. After the reaction vessel was cooled in an ice water bath for 1.5 hours, excess hydrogen was slowly allowed to be discharged.
- a ruthenium complex la (8.7 mg, 0.0143 mmol), potassium t-butoxide (1.6 mg, 0.0143 mmol), tetrahydrofuran (20 mL), 4,4-dimethyl was added to a 125 mL autoclave.
- Base-1,3-dioxan-2-one (3.32 g, 28.6 mmol) o
- the autoclave was sealed and removed from the glove box and filled with hydrogen at 50 atm.
- the reaction vessel was stirred and heated in an oil bath at 140 ° C for 12 hours. After the reaction vessel was cooled in an ice water bath for 1.5 hours, excess hydrogen was slowly allowed to be discharged.
- a ruthenium complex la 17.4 mg, 0.0286 mmol
- potassium t-butoxide 3.2 mg, 0.0286 mmol
- tetrahydrofuran (20 mL)
- 4, 4, 5 were added to a 125 mL autoclave.
- 5-Tetramethyl- 1 ,3-dioxan-2-one (4.12 g, 28.6 mmol) o
- the autoclave was sealed and removed from the glove box and filled with hydrogen at 50 atm.
- the reaction kettle was stirred and heated in an oil bath at 140 ° C for 20 hours. After the reaction vessel was cooled in an ice water bath for 1.5 hours, excess hydrogen was slowly allowed to be discharged.
- Example 21 Rhodium complex catalyzed hydrogenation of a cyclic carbonate 1,3-dioxan-2-one
- a ruthenium complex la (8.7 mg, 0.0143 mmol), potassium t-butoxide (1.6 mg, 0.0143 mmol), tetrahydrofuran (20 mL), 1,3-dioxane were added to a 125 mL autoclave.
- Heterocyclohexan-2-one (2.92 g, 28.6 mmol).
- the autoclave was sealed and taken out of the glove box and filled with hydrogen at 50 atm.
- Reaction kettle at 140 ° C The reaction was stirred with heating in an oil bath for 2 hours. After the reactor was cooled in an ice water bath for 1.5 hours, excess hydrogen was slowly released.
- Example 22 Degradation hydrogenation of poly(propylene carbonate) catalyzed by ruthenium complex la
- a ruthenium complex la (15.8 mg, 0.0260 mmol), potassium t-butoxide (2.9 mg, 0.0260 mmol), tetrahydrofuran (25 mL), polypropylene carbonate [M) was added to a 125 mL autoclave.
- the autoclave was sealed and taken out of the glove box and filled with hydrogen at 50 atm.
- the reaction kettle was stirred and heated in an oil bath at 140 ° C for 24 hours. After the reactor was cooled in an ice water bath for 1.5 hours, excess hydrogen was slowly released.
- Example 23 Deuteration of ethylene carbonate catalyzed by ruthenium complex la to prepare deuterated methanol and deuterated ethylene glycol
- a ruthenium complex la 17.4 mg, 0.0286 mmol
- potassium t-butoxide 3.2 mg, 0.0286 mmol
- tetrahydrofuran 20 mL
- ethylene carbonate 2.52 g
- the reaction kettle was stirred and heated in an oil bath at 140 ° C for 0.5 hour. After the reaction vessel was cooled in an ice water bath for 1.5 hours, excess helium gas was slowly allowed to escape.
- Example 25 Hydrogenation of ruthenium carbonate catalyzed by ruthenium complexes lc and le to prepare methanol and ethylene glycol
- Example 26 Hydrazine complex catalyzed hydrogenation of dimethyl carbonate to produce methanol
- a ruthenium complex la (17.4 mg, 0.0286 mmol), potassium t-butoxide (3.2 mg, 0.0286 mmol), tetrahydrofuran (10 mL), dimethyl carbonate (2.57) were added to a 125 mL autoclave. g, 28.6 mmol) o After the autoclave was sealed, it was taken out of the glove box and filled with hydrogen at 50 atm. The reaction kettle was stirred and heated in an oil bath at 140 ° C for 10 hours. After the reaction vessel was cooled in an ice water bath for 1.5 hours, excess hydrogen was slowly allowed to be discharged.
- Example 27 Complex of [P(N-Me)P]-clamped ligand with ruthenium hydrogenation of propylene carbonate catalyzed by la'
- Example 28 Effect of different amounts of alkali on the hydrogenation of propylene carbonate catalyzed by ruthenium complex la.
- a procedure similar to that of Example 11 was carried out using ruthenium complex la as a catalyst in different bases and ruthenium complexes.
- the molar ratio of the molar ratio and the reaction conditions shown below, the catalytic hydrogenation of propylene carbonate, the reaction at 100 ° C for 2 hours, the reaction results are shown in the following table:
- Example 29 Hydrogenation of propylene carbonate in toluene catalyzed by ruthenium complex la
- a ruthenium complex la (1.8 mg, 0.028 mmol), potassium t-butoxide (0.25 mg, 0.028 mmol), toluene (20 mL), propylene carbonate (2.92 g) was added to a 125 mL autoclave.
- a ruthenium complex la (1.8 mg, 0.028 mmol), potassium t-butoxide (0.25 mg, 0.028 mmol), dioxane (20 mL), propylene carbonate were added to a 125 mL autoclave. (2.92 g, 28.6 mmol) o After the autoclave was sealed, it was taken out of the glove box and filled with hydrogen at 50 atm. The reaction kettle was stirred and heated in an oil bath at 100 ° C for 10 hours. After the reaction vessel was cooled in an ice water bath for 1.5 hours, excess hydrogen was slowly released. Using p-xylene as an internal standard, the conversion of the raw material was determined by gas chromatography to be 99%. Both methanol and diol yields were 99%.
- Example 31 Ruthenium acrylate catalyzed hydrogenation of propylene carbonate at different temperatures
- Example 32 Hydrogenation of propylene carbonate catalyzed by ruthenium complex la under different hydrogen pressures A similar procedure as in Example 11 was carried out, using ruthenium complex la as a catalyst to carry out catalysis of propylene carbonate under different hydrogen pressures. Hydrogenation, reaction at 100 ° C for 2 hours, the reaction results shown in the following table were obtained.
- Example 33 Hydrogenation of diphenyl carbonate catalyzed by ruthenium complex la. Preparation of methanol and phenol In a glove box, a ruthenium complex la (17.4 mg, 0.0286 mmol), tert-butyl was added to a 125 mL autoclave. Potassium alkoxide (3.2 mg, 0.0286 mmol), tetrahydrofuran (10 mL), diphenyl carbonate (0.61 g, 2.86 mmol).
- the autoclave was sealed and removed from the glove box and filled with hydrogen at 50 atm.
- the reactor was at 140 ° C.
- the reaction was heated and stirred for 10 hours in an oil bath. After cooling the reaction vessel in an ice water bath for 1.5 hours, excess hydrogen was slowly released.
- the conversion of diphenyl carbonate was determined by gas chromatography using p-xylene as an internal standard. 100%, the yield of methanol was 95%, and the yield of phenol was 99%.
- the ruthenium complex la (17.4 mg, 0.0286 mmol) was mixed with potassium t-butoxide (3.2 mg, 0.0286 mmol) in tetrahydrofuran (10 mL) under an inert atmosphere, stirred at room temperature for 30 min and then dried. The solvent was further added with benzene (20 mL), stirred at room temperature for 10 min and then filtered, and the filtrate was evaporated to dryness. In hand In a box, this neutral ruthenium complex, tetrahydrofuran (20 mL), propylene carbonate (2.92 g, 28.6 mmol) was added to a 125 mL autoclave.
- the autoclave was sealed and taken out of the glove box and filled with hydrogen at 50 atm.
- the reaction kettle was stirred and heated in an oil bath at 140 ° C for 10 hours. After the reactor was cooled in an ice water bath for 1.5 hours, excess hydrogen was slowly released.
- p-xylene as an internal standard, the conversion of the reaction was determined by gas chromatography to be 99%. The yields of both methanol and diol were 99%.
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US14/436,842 US9434665B2 (en) | 2012-10-19 | 2013-03-22 | Ruthenium complex and method for preparing methanol and diol |
EP13847202.2A EP2910540B1 (en) | 2012-10-19 | 2013-03-22 | Novel ruthenium complex and method for preparing methanol and diol |
JP2015537109A JP6190886B2 (ja) | 2012-10-19 | 2013-03-22 | 新規なルテニウム錯体ならびにメタノールおよびジオールの製造方法 |
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EP3135681A4 (en) * | 2014-04-25 | 2017-09-20 | Takasago International Corporation | Ruthenium complex, method for producing same, and use of same |
CN115920973A (zh) * | 2023-03-10 | 2023-04-07 | 泽升科技(广州)有限公司 | 一种全氘代甲醇的制备方法 |
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CN108137637B (zh) * | 2015-09-30 | 2020-05-08 | 高砂香料工业株式会社 | 钌配合物的制造方法 |
CN105597829B (zh) * | 2016-01-07 | 2018-11-06 | 神华集团有限责任公司 | 催化剂、其制备方法及其在甲醇和二醇合成中的应用 |
CN105541548B (zh) * | 2016-01-07 | 2018-05-25 | 神华集团有限责任公司 | 甲醇和二醇的制备方法 |
EP3615205A4 (en) * | 2017-04-27 | 2020-12-09 | Deuteria Beverages LLC | PROCESS FOR PREPARING DEUTERATED ETHANOL FROM D2 |
CN107973695A (zh) * | 2017-11-20 | 2018-05-01 | 中国科学院过程工程研究所 | 非取代氨基甲酸酯加氢合成甲醇的方法及应用 |
DE102018133689A1 (de) * | 2018-12-28 | 2020-07-02 | CreativeQuantum GmbH | Verfahren zur Herstellung von Methanol |
CN110975939A (zh) * | 2019-12-19 | 2020-04-10 | 华东师范大学 | 一种碳酸乙烯酯加氢多相催化剂及其制备方法和应用 |
CN114768803B (zh) * | 2022-05-07 | 2023-11-10 | 南京凝氘生物科技有限公司 | 一种合成全氘代甲醇的催化剂、其制备方法及其应用 |
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CN115920973A (zh) * | 2023-03-10 | 2023-04-07 | 泽升科技(广州)有限公司 | 一种全氘代甲醇的制备方法 |
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CN103772142A (zh) | 2014-05-07 |
JP2015536922A (ja) | 2015-12-24 |
CN103772142B (zh) | 2018-04-27 |
US20160060195A1 (en) | 2016-03-03 |
EP2910540A1 (en) | 2015-08-26 |
EP2910540B1 (en) | 2021-09-15 |
EP2910540A4 (en) | 2016-06-22 |
JP6190886B2 (ja) | 2017-08-30 |
US9434665B2 (en) | 2016-09-06 |
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