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  • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
  • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
  • C07D487/04—Ortho-condensed systems
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  • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• • A—HUMAN NECESSITIES
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  • A61P25/00—Drugs for disorders of the nervous system
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  • A61P25/00—Drugs for disorders of the nervous system
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• • A—HUMAN NECESSITIES
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  • A61P9/00—Drugs for disorders of the cardiovascular system

Definitions

• the present invention relates to compounds of general formula I
• R 1 is hydrogen, halogen, lower alkyl, lower alkoxy, lower alkoxy substituted by halogen or cyano;
• R 2 is hydrogen, lower alkyl or lower alkyl substituted by halogen
• R 3 is phenyl, benzo[l,3]dioxolyl, 2,3-dihydro-benzofuran-5-yl or a 5- and 6-membered heteroaryl, wherein phenyl and the 5- and 6-membered heteroaryl groups may be substituted by one or more substituents, selected from cyano, nitro, amino and lower di-alkylamino, lower alkyl sulfonyl, lower alkoxy, lower alkoxy substituted by halogen, halogen, lower alkyl, lower alkyl substituted by halogen or lower alkyl substituted by hydroxyl;
• X is -CH(lower alkyl)-, -CH 2 -, -CH 2 CH 2 - or -CH(lower alkyl)CH 2 -;
• R is hydrogen or lower alkyl; n is 1 or 2; or to a pharmaceutically acceptable acid addition salt, to a racemic mixture or to its
• NSCs neural stem cells
• hippocampal adult neurogenesis plays an important role in cognitive and emotional states albeit the precise function remains elusive. It has been argued that the relatively small number of newborn granule neurons can affect global brain function because they innervate many interneurons within the dentate gyrus, each of which inhibits hundreds of mature granule cells leading to a neurogenesis-dependent feedback inhibition. In combination with a low threshold for firing the newborn neurons trigger responses to very subtle changes in context. Disturbances in this process may manifest behaviorally in deficits in pattern separation related to psychiatric diseases. For example, adult hippocampal neurogenesis correlates with cognitive and emotional capacity, e.g. physical exercise, exposure to an enriched environment and typical antidepressants concomitantly promote adult hippocampal
• Neurogenesis and cognition and/or emotional states decrease adult neurogenesis and associate with negative cognitive and/or emotional states (Neuron 70, May 26, 2011, pp 582 -588 and pp 687 - 702; WO 2008/046072).
• antidepressants promote hippocampal adult neurogenesis and their effects on certain behaviors require the stimulation of neurogenesis.
• Neurogenesis in other adult CNS regions is generally believed to be very limited under normal physiological conditions, but could be induced after injury such as stroke, and central and peripheral brain damage.
• stimulation of adult neurogenesis represents a neuro- regenerative therapeutic target for normal aging and in particular for a variety of
• neurodegenerative and neuropsychiatric diseases including schizophrenia, obsessive - compulsive personality disorder, major depression, bipolar disorders, anxiety disorders, epilepsy, retinal degeneration, traumatic brain injury, spinal cord injury, post-traumatic stress disorder, panic disorder, Parkinson's disease, dementia, Alzheimer's disease, mild cognitive impairment, chemotherapy-induced cognitive dysfunction ("chemobrain”), Down syndrome, autism spectrum disorders, hearing loss (N euro science, 167 (2010) 1216-1226; Nature
• the object of the present invention was to identify compounds that modulate neurogenesis. It has been found that the compounds of formula I are active in this area and they may therefore be used for the treatment of schizophrenia, obsessive-compulsive personality disorder, major depression, bipolar disorders, anxiety disorders, normal aging, epilepsy, retinal degeneration, traumatic brain injury, spinal cord injury, post-traumatic stress disorder, panic disorder, Parkinson's disease, dementia, Alzheimer's disease, mild cognitive impairment, chemotherapy- induced cognitive dysfunction ("chemobrain”), Down syndrome, autism spectrum disorders, hearing loss, tinnitus, spinocerebellar ataxia, amyotrophic lateral sclerosis, multiple sclerosis, Huntington's disease, stroke, and disturbances due to radiation therapy, chronic stress, or abuse of neuro-active drugs, such as alcohol, opiates, methamphetamine, phencyclidine and cocaine.
• neuro-active drugs such as alcohol, opiates, methamphetamine, phencyclidine and cocaine.
• the most preferred indications for compounds of formula I are Alzheimer's disease, depression, anxiety disorders and stroke.
• the present invention relates to compounds of formula I and to their pharmaceutically acceptable salts, to these compounds as pharmaceutically active substances, to the processes for their production, as well as to the use in the treatment or prevention of disorders, relating to neurogenesis, schizophrenia, obsessive-compulsive personality disorder, major depression, bipolar disorders, anxiety disorders, normal aging, epilepsy, retinal degeneration, traumatic brain injury, spinal cord injury, post-traumatic stress disorder, Parkinson's disease, dementia, Alzheimer's disease, mild cognitive impairment, chemotherapy-induced cognitive dysfunction, Down syndrome, autism spectrum disorders, hearing loss, tinnitus, spinocerebellar ataxia, amyotrophic lateral sclerosis, multiple sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of neuro-active drugs, such as alcohol, opiates,
• lower alkyl denotes a saturated, i.e. aliphatic hydrocarbon group including a straight or branched carbon chain with 1 - 7 carbon atoms.
• alkyl examples are methyl, ethyl, n-propyl, isopropyl, n- butyl, i-butyl, 2-butyl, t-butyl and the like. Preferred alkyl groups with 1 - 4 carbon atoms.
• alkoxy denotes a group -O-R' wherein R' is lower alkyl as defined above.
• lower alkyl sulfonyl denotes a group -S(0) 2 R' wherein R' is lower alkyl as defined above.
• halogen denotes chlorine, bromine, fluorine or iodine.
• lower alkyl substituted by halogen denotes an alkyl group as defined above, wherein at least one hydrogen atoms is replaced by halogen, for example CF 3 , CH 2 F, CH 2 CF 3 , CH 2 CH 2 CF 3 , CH 2 CF 2 CF 3 and the like.
• lower alkyl substituted by hydroxy denotes an alkyl group as defined above, wherein at least one hydrogen atom is replaced by hydroxy, for example CH 2 OH, CH 2 CH 2 OH, C(CH 3 ) 2 OH and the like.
• 5- and 6-membered heteroaryl denotes aromatic rings with 5 or 6 ring atoms, containing at least one N, S or O atom, for example pyridinyl, 1,3,4-thiadiazolyl, thiazolyl, thiophenyl, furanyl or pyrimidinyl.
• pharmaceutically acceptable salt or “pharmaceutically acceptable acid addition salt” embraces salts with inorganic and organic acids, such as hydrochloric acid, nitric acid, sulfuric acid, phosphoric acid, citric acid, formic acid, fumaric acid, maleic acid, acetic acid, succinic acid, tartaric acid, methane-sulfonic acid, p-toluenesulfonic acid and the like
• R 1 is hydrogen, halogen, lower alkyl, lower alkoxy, lower alkoxy substituted by halogen or cyano; is hydrogen, lower alkyl or lower alkyl substituted by halogen;
• R 3 is phenyl, which may be substituted by one or more substituents, selected from cyano, nitro, amino and lower di-alkylamino, lower alkyl sulfonyl, lower alkoxy, lower alkoxy substituted by halogen, halogen, lower alkyl, lower alkyl substituted by halogen or lower alkyl substituted by hydroxyl;
• X is -CH(lower alkyl)-, -CH 2 -, -CH 2 CH 2 - or -CH(lower alkyl)CH 2 -;
• R is hydrogen or lower alkyl; n is 1 or 2; or a pharmaceutically acceptable acid addition salt, a racemic mixture or to its corresponding enantiomer and/or optical isomers thereof.
• formula IA The following examples are encompassed by formula IA:
• R is hydrogen, halogen, lower alkyl, lower alkoxy, lower alkoxy substituted by halogen or cyano; is hydrogen, lower alkyl or lower alkyl substituted by halogen; is pyridinyl or pyrimidinyl, which may be substituted by one or more substituents, selected from cyano, nitro, amino and lower di-alkylamino, lower alkyl sulfonyl, lower alkoxy, lower alkoxy substituted by halogen, halogen, lower alkyl, lower alkyl substituted by halogen or lower alkyl substituted by hydroxyl;
• X is -CH(lower alkyl)-, -CH 2 -, -CH 2 CH 2 - or -CH(lower alkyl)CH 2 -;
• R is hydrogen or lower alkyl; n is 1 or 2; or a pharmaceutically acceptable acid addition salt, a racemic mixture or to its corresponding enantiomer and/or optical isomers thereof.
• a further object of the present invention are compounds of formula
• R 1 is hydrogen, halogen, lower alkyl, lower alkoxy, lower alkoxy substituted by halogen or cyano
• R 2 is hydrogen, lower alkyl or lower alkyl substituted by halogen
• R 3 is benzo[ l ,3]dioxolyl or 2,3-dihydro-benzofuranyl;
• X is -CH(lower alkyl)-, -CH 2 -, -CH 2 CH 2 - or -CH(lower alkyl)CH 2 -,
• R is hydrogen
• n 1 ;
• R 1 is hydrogen, halogen, lower alkyl, lower alkoxy, lower alkoxy substituted by halogen or cyano;
• R 2 is hydrogen, lower alkyl or lower alkyl substituted by halogen
• R 3 is a 5- membered heteroaryl, which may be substituted by one or more substituents, selected from cyano, nitro, amino and lower di-alkylamino, lower alkyl sulfonyl, lower alkoxy, lower alkoxy substituted by halogen, halogen, lower alkyl, lower alkyl substituted by halogen or lower alkyl substituted by hydro xyl;
• X is -CH(lower alkyl)-, -CH 2 -, -CH 2 CH 2 - or -CH(lower alkyl)CH 2 -;
• R is hydrogen or lower alkyl; n is 1 or 2; or a pharmaceutically acceptable acid addition salt, a racemic mixture or to its corresponding enantiomer and/or optical isomers thereof, for example the following compounds
• a further embodiment of the invention are compounds of formula I, wherein X is
• a further embodiment of the invention are compounds of formula I, wherein X is -CH 2 -.
• a further embodiment of the invention are compounds of formula I, wherein X is -CH 2 CH 2 -.
• a further embodiment of the invention are compounds of formula I, wherein X is -CH(lower alkyl)CH 2 -.
• the compounds of formula I can be manufactured by the methods given below, by the methods given in the examples or by analogous methods. Appropriate reaction conditions for the individual reaction steps are known to a person skilled in the art.
• the reaction sequence is not limited to the one displayed in scheme 1, however, depending on the starting materials and their respective reactivity the sequence of reaction steps can be freely altered.
• Isolation and purification of the compounds and intermediates described herein can be effected, if desired, by any suitable separation or purification procedure such as, for example, filtration, extraction, crystallization, column chromatography, thin- layer chromatography, thick- layer chromatography, preparative low or high-pressure liquid chromatography or a combination of these procedures.
• suitable separation and isolation procedures can be had by reference to the preparations and examples herein below. However, other equivalent separation or isolation procedures could, of course, also be used.
• the compounds of formula I are basic and may be converted to a corresponding acid addition salt.
• the conversion is accomplished by treatment with at least a stoichiometric amount of an appropriate acid, such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid and the like, and organic acids such as acetic acid, propionic acid, glycolic acid, pyruvic acid, oxalic acid, malic acid, malonic acid, succinic acid, maleic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, salicylic acid and the like.
• an appropriate acid such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid and the like
• organic acids such as acetic acid, propionic acid, glycolic acid,
• the free base is dissolved in an inert organic solvent such as diethyl ether, ethyl acetate, chloroform, ethanol or methanol and the like, and the acid added in a similar solvent.
• an inert organic solvent such as diethyl ether, ethyl acetate, chloroform, ethanol or methanol and the like.
• the temperature is maintained between 0 °C and 50 °C.
• the resulting salt precipitates spontaneously or may be brought out of solution with a less polar solvent.
• the acid addition salts of the basic compounds of formula I may be converted to the corresponding free bases by treatment with at least a stoichiometric equivalent of a suitable base such as sodium or potassium hydroxide, potassium carbonate, sodium bicarbonate, ammonia, and the like.
• a suitable base such as sodium or potassium hydroxide, potassium carbonate, sodium bicarbonate, ammonia, and the like.
• compounds of the present invention have an activity as neurogenic agents.
• Neurogenic properties of small molecules are determined based on the proliferation of human embryonic stem cell derived neural stem cells (NSCs) which were derived via a dual smad inhibition as previously described (Chambers, S.M., et al, Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling, Nature biotechnology, 2009. 27(3): p. 275-80.)
• NSCs human embryonic stem cell derived neural stem cells
• Compounds respond is measured by the increase in cells based on ATP levels (Promega:CellTiterGlo®) after an incubation period of 4 days.
• NSCs are thawed and expanded over 3 passages. On the 14 th day, NSCs are seeded in
• Negative (neutral) control is cell culture Media (final DMSO concentration: 0.25 %).
• ATP is quantified.
• the ATP concentration is proportional to the cell number.
• ATP is quantified by using the Promega CellTiterGlo® kit.
• the CellTiterGlo® reagents contain a cell lysis buffer, a thermo stable luciferase (UltraGloTM recombinant luciferase), magnesium and luciferin. Luciferin reacts with ATP producing oxyluciferin, AMP and light. The luminescence signal is proportional to the ATP content.
• the value of negative (neutral) control is determined for each assay plate by taking the average of 16 negative control wells.
• the neurogenic compound response is calculated for each compound as (compound/Negative Control)* 100.
• the values of EC150 from the dose response curve are determined for each test compound.
• the EC150 is the compound concentration at which 150 % activity of control (100 %) is reached.
• the preferred compounds show a EC150 ( ⁇ ) in the range of ⁇ 4.0 ⁇ as shown in the table below.
• the 299 compounds of formula (I) and pharmaceutically acceptable salts thereof can be used as medicaments, e.g. in the form of pharmaceutical preparations.
• the pharmaceutical preparations can be administered orally, e.g. in the form of tablets, coated tablets, dragees, hard and soft gelatine capsules, solutions, emulsions or suspensions.
• the administration can also be effected rectally, e.g. in the form of suppositories, or parenterally, e.g. in the form of injection solutions.
• the compounds of formula (I) and pharmaceutically acceptable salts thereof can be processed with pharmaceutically inert, inorganic or organic carriers for the production of pharmaceutical preparations.
• Lactose, corn starch or derivatives thereof, talc, stearic acid or its salts and the like can be used, for example, as such carriers for tablets, coated tablets, dragees and hard gelatine capsules.
• Suitable carriers for soft gelatine capsules are, for example, vegetable oils, waxes, fats, semi-solid and liquid polyols and the like; depending on the nature of the active substance no carriers are, however, usually required in the case of soft gelatine capsules.
• Suitable carriers for the production of solutions and syrups are, for example, water, polyols, sucrose, invert sugar, glucose and the like.
• Adjuvants such as alcohols, polyols, glycerol, vegetable oils and the like, can be used for aqueous injection solutions of water-soluble salts of compounds of formula (I), but as a rule are not necessary.
• Suitable carriers for suppositories are, for example, natural or hardened oils, waxes, fats, semi-liquid or liquid polyols and the like.
• the pharmaceutical preparations can contain preservatives, solubilizers, stabilizers, wetting agents, emulsifiers, sweeteners, colorants, flavorants, salts for varying the osmotic pressure, buffers, masking agents or antioxidants. They can also contain still other therapeutically valuable substances.
• pharmaceutically acceptable salts thereof and a therapeutically inert excipient are also an object of the present invention, as is a process for the production of such medicaments which comprises bringing one or more compounds of formula (I) or pharmaceutically acceptable salts thereof and, if desired, one or more other therapeutically valuable substances into a galenical dosage form together with one or more therapeutically inert carriers.
• the dosage can vary within wide limits and will, of course, be fitted to the individual requirements in each particular case.
• the effective dosage for oral or parenteral administration is between 0.01-20 mg/kg/day, with a dosage of 0.1-10 mg/ kg/day being preferred for all of the indications described.
• compositions comprising compounds of the invention:
• step A To a stirred solution of ethyl 7-bromo-l-(2-(tert-butoxycarbonylamino)ethyl)-5-fluoro-lH- indole-2-carboxylate (step A) (1.43 g, 3.33 mmol) in dichloromethane (15.2 ml) was added drop wise at 0°C trifluoro acetic acid (4.79 g, 3.23 ml, 42.0 mmol). Afterwards the solution was allowed to stir for 15min at 0°C, and for 30 min at room temperature. The reaction mixture was evaporated and the remaining material was solved in methanol (15.2 ml).
• step A A stirred solution of (2-bromo-4,5-difluoro-phenyl)-hydrazine (step A) (4.29 g, 19.2 mmol) in ethanol (13.8 ml) was cooled to 0°C and a solution of ethyl pyruvate (2.39 g, 2.3 ml, 20.0 mmol) in ethanol (4 ml) was added drop wise at 0°C for 15 min.
• step A A stirred solution of (2-bromo-4-chloro-phenyl)-hydrazine (step A) (1.98 g, 8.94 mmol) in ethanol (6.5 ml) was cooled to 0°C and a solution of commercially available methyl 2- ketobutyrate (1.08 g, 1.04 ml, 9.3 mmol) in ethanol (2 ml) was added drop wise at 0°C for 15 min. After the mixture was allowed to stir at room temperature for 3h it was evaporated.
• step B To a stirred solution of (Z)-2-[(2-bromo-4-chloro-phenyl)-hydrazono]-butyric acid methyl ester (step B) (2.67 g, 8.35 mmol) in acetic acid (30 ml) was added at room temperature zinc chloride (6.26 g, 46.0 mmol) and the mixture was allowed to stir for lh under reflux conditions.
• reaction mixture was poured into ice/water (50 ml) and extracted with ethyl acetate (2 x 50 ml). The combined organic layers were washed with brine (50 ml), dried (MgS04) and evaporated.
• step A A mixture of (2-bromo-4-cyano-6-iodo-phenyl)-carbamic acid tert-butyl ester (step A) (413 mg, 0.98 mmol), 3,3-diethoxyprop-l-yne (125 mg, 140 ⁇ , 0.98 mmol), triethylamine (395 mg, 544 ⁇ , 3.9 mmol), copper(I)iodide (5.58 mg, 29.3 ⁇ ) and bis(triphenylphosphine)- palladium(II)chloride (34.3 mg, 48.8 ⁇ ) was allowed to stir for 3h at room temperature.
• 263.5°C was prepared in accordance with the general method of example 1 from 7-bromo-9- fluoro-2,3,4,5-tetrahydro-[l,4]diazepino[l,2-a]indol-l-one (intermediate 2) (74.3 mg, 0.25 mmol) and commercially available 4-chloro-phenylboronic acid (50.8 mg, 0.325 mmol).

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