WO2013185487A8 - 基于金纳米簇的肿瘤靶向活体多模态成像方法 - Google Patents

基于金纳米簇的肿瘤靶向活体多模态成像方法 Download PDF

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WO2013185487A8
WO2013185487A8 PCT/CN2013/070928 CN2013070928W WO2013185487A8 WO 2013185487 A8 WO2013185487 A8 WO 2013185487A8 CN 2013070928 W CN2013070928 W CN 2013070928W WO 2013185487 A8 WO2013185487 A8 WO 2013185487A8
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imaging
tumor
targeting
living body
gold nanoclusters
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WO2013185487A1 (zh
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王雪梅
王建玲
李奇维
姜晖
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东南大学
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Publication of WO2013185487A8 publication Critical patent/WO2013185487A8/zh

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Abstract

一种基于金纳米簇的肿瘤靶向活体多模态成像分析方法，包括：通过包括不同种类肿瘤细胞及正常细胞的体外细胞实验，将相关细胞与一定浓度的氯金酸及其盐溶液在生理条件下孵育产生金纳米簇，实现了实时非侵入性的高分辨肿瘤细胞荧光成像、拉曼成像及超声成像。在此基础上，进一步采用局部皮下注射方法，在移植肿瘤裸鼠模型上实现了实时原位活体肿瘤靶向荧光、拉曼和超声成像。该功能性纳米探针将肿瘤靶向、荧光成像、拉曼成像以及超声成像多功能融为一体，能够实现多模态的同步监测；同时，这种基于金纳米簇的原位活体成像方法能够进行准确定位与肿瘤靶向成像分析。
PCT/CN2013/070928 2012-06-11 2013-01-24 基于金纳米簇的肿瘤靶向活体多模态成像方法 WO2013185487A1 (zh)

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US14/567,972 US9724431B2 (en) 2012-06-11 2014-12-11 Tumor-targeting multi-mode imaging method for living body based on gold nanoclusters

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CN102735752B (zh) * 2012-06-11 2014-09-10 东南大学 基于金纳米簇的肿瘤靶向活体多模态成像方法
CN103099604B (zh) * 2013-01-15 2015-05-06 东南大学 一种基于锌离子信号增强效应的肿瘤靶向成像方法
CN103083687B (zh) * 2013-01-16 2016-04-13 东南大学 一种银、铂纳米簇在肿瘤靶向成像的应用
CN103143037B (zh) * 2013-03-01 2015-01-28 东南大学 一种基于稀土金属化合物纳米簇的合成方法及应用
CN103196883A (zh) * 2013-04-19 2013-07-10 中国科学院化学研究所 一种利用金纳米团簇测定糜蛋白酶活性的方法
CN103212056B (zh) * 2013-05-07 2015-07-08 东南大学 一种基于金、银及金银混合物与谷胱甘肽/壳聚糖制剂及其应用
CN103820114B (zh) * 2014-03-04 2016-02-03 东南大学 一种基于稀土金属铈的荧光纳米簇的制备方法及其应用
CN104101584B (zh) * 2014-06-12 2017-04-05 东南大学 金纳米簇作为谷胱甘肽荧光探针的应用
CN104807795A (zh) * 2015-05-06 2015-07-29 江南大学 一种亲生物性铜纳米簇的快速制备方法
CN106596494B (zh) * 2016-12-29 2019-05-10 青岛科技大学 一种基于荧光传感阵列的快速筛查早中晚期乳腺癌技术
CN106880338B (zh) * 2017-03-02 2019-11-08 重庆大学 基于表面增强拉曼散射技术的肿瘤原位在线检测系统
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CN108956563A (zh) * 2018-06-21 2018-12-07 东南大学 一种以肿瘤细胞原位生物合成多功能金属纳米探针的方法
CN109047791B (zh) * 2018-08-20 2021-08-06 河南大学 金纳米颗粒及其合成方法
CN109797172A (zh) * 2019-01-24 2019-05-24 东南大学 一种与外源性核酸原位合成三维结构的方法
CN109793515B (zh) * 2019-01-31 2022-08-02 中国科学院电工研究所 一种电性粒子成像方法及信号检测装置
CN111227799B (zh) * 2020-01-21 2021-04-27 中国农业大学 脑组织甲基汞的活体检测的高灵敏度生物探针的制作方法
CN111235216A (zh) * 2020-02-26 2020-06-05 东南大学 一种智能生物探针的致病微生物精准检测及杀灭方法
CN111909900A (zh) * 2020-07-19 2020-11-10 东南大学 一种基于原位自组装智能纳米颗粒增强免疫应答的方法
CN112111552A (zh) * 2020-08-05 2020-12-22 青岛科技大学 一种肿瘤细胞的荧光成像方法
CN112656943B (zh) * 2020-12-30 2022-12-23 临沂大学 一种铜单原子/金团簇多功能诊疗剂的制备方法与应用

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WO2013185487A1 (zh) 2013-12-19
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US9724431B2 (en) 2017-08-08
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