WO2013170221A1 - Use of semaphorin-4d binding molecules to promote neurogenesis following stroke - Google Patents

Use of semaphorin-4d binding molecules to promote neurogenesis following stroke Download PDF

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Publication number
WO2013170221A1
WO2013170221A1 PCT/US2013/040661 US2013040661W WO2013170221A1 WO 2013170221 A1 WO2013170221 A1 WO 2013170221A1 US 2013040661 W US2013040661 W US 2013040661W WO 2013170221 A1 WO2013170221 A1 WO 2013170221A1
Authority
WO
WIPO (PCT)
Prior art keywords
sema4d
antibody
antigen
binding molecule
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2013/040661
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English (en)
French (fr)
Inventor
Ernest S. Smith
Maurice Zauderer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vaccinex Inc
Original Assignee
Vaccinex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES13787931T priority Critical patent/ES2882881T3/es
Priority to AU2013259192A priority patent/AU2013259192B2/en
Priority to EP13787931.8A priority patent/EP2846831B1/en
Priority to EA201492067A priority patent/EA030796B1/ru
Priority to CA2872928A priority patent/CA2872928C/en
Priority to JP2015511789A priority patent/JP6218810B2/ja
Priority to NZ630864A priority patent/NZ630864A/en
Priority to DK13787931.8T priority patent/DK2846831T3/da
Priority to MX2014013676A priority patent/MX358991B/es
Application filed by Vaccinex Inc filed Critical Vaccinex Inc
Priority to SG11201407416XA priority patent/SG11201407416XA/en
Priority to KR1020147034510A priority patent/KR102105436B1/ko
Priority to BR112014028160-2A priority patent/BR112014028160B1/pt
Priority to CN201380037262.9A priority patent/CN104619341A/zh
Publication of WO2013170221A1 publication Critical patent/WO2013170221A1/en
Priority to IL235603A priority patent/IL235603B/en
Anticipated expiration legal-status Critical
Priority to ZA2015/01674A priority patent/ZA201501674B/en
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Definitions

  • a method for alleviating a symptom of a disease or disorder of the central nervous system, such as stroke, in a patient comprising administering to the subject an effective amount of an isolated binding molecule which specifically binds to and/or inhibits to semaphorin-4D (SEMA4D), wherein the binding to SEMA4D acts to alleviate the symptom.
  • SEMA4D semaphorin-4D
  • progenitor cell refers to a cell derived from a stem cell that is not itself a stem cell. Some progenitor cells can produce progeny that are capable of differentiating into more than one cell type. Neural progenitor cells include neuronal progenitor cells, which produce neurons, and glial progenitor cells that produce astroglial and/or oligodendroglial cells.
  • central nervous system disorder or a “CNS disorder” refers to a neurodegenerative disorder, acute brain injury (e.g. stroke, head injury, cerebral palsy, cerebral infarction, spinal cord injury, traumatic injury) and certain central nervous system "CNS" dysfunctions (e.g. depression, epilepsy, and schizophrenia).
  • SEMA4D has been shown to promote T cell stimulation and B cell aggregation and survival in vitro.
  • the addition of SEMA4D-expressing cells or sSEMA4D enhances CD40-induced B cell proliferation and immunoglobulin production in vitro, and accelerates in vivo antibody responses (Ishida et al, Inter. Immunol. 75:1027-1034 (2003); Kumanogoh and H. Kukutani, Trends in Immunol 22:670-676 (2001)).
  • sSEMA4D enhances the CD40 induced maturation of DCs, including up-regulation of costimulatory molecules and increased secretion of IL-12.
  • the constant region of an anti-SEMA4D antibody can be mutated to alter effector function in a number of ways. For example, see U.S. Pat. No. 6,737,056B1 and U.S. Patent Application Publication No. 2004/0132101 Al, which disclose Fc mutations that optimize antibody binding to Fc receptors.
  • the pharmaceutical composition comprising the anti-SEMA4D binding molecule may be delivered in any conventional form, including any form known in the art in which it may pass through the blood brain barrier (i.e., act on the brain side). Due to the interaction of SEMA4D with a receptor on astrocytes, which are brain-resident cells important for the maintenance of blood brain barrier integrity, the application or administration of the anti-SEMA4D binding molecule may occur on the brain side of the blood brain barrier to block the interaction of SEMA4D with its receptor on astrocytes.
  • Methods for allowing factors to pass through the blood-brain barrier include minimizing the size of the factor, providing hydrophobic factors which may pass through more easily, conjugating the modulating agent to a carrier molecule that has a substantial permeability coefficient across the blood brain barrier.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PCT/US2013/040661 2012-05-11 2013-05-10 Use of semaphorin-4d binding molecules to promote neurogenesis following stroke Ceased WO2013170221A1 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
MX2014013676A MX358991B (es) 2012-05-11 2013-05-10 Uso de moleculas de enlace a la semaforina-4d para promover la neurogenesis despues de la apoplejia.
EP13787931.8A EP2846831B1 (en) 2012-05-11 2013-05-10 Use of semaphorin-4d binding molecules to promote neurogenesis following stroke
SG11201407416XA SG11201407416XA (en) 2012-05-11 2013-05-10 Use of semaphorin-4d binding molecules to promote neurogenesis following stroke
CA2872928A CA2872928C (en) 2012-05-11 2013-05-10 Use of semaphorin-4d binding molecules to promote neurogenesis following stroke
JP2015511789A JP6218810B2 (ja) 2012-05-11 2013-05-10 卒中後の神経形成を促進するためのセマフォリン−４ｄ結合分子の使用
NZ630864A NZ630864A (en) 2012-05-11 2013-05-10 Use of semaphorin-4d binding molecules to promote neurogenesis following stroke
DK13787931.8T DK2846831T3 (en) 2012-05-11 2013-05-10 Use of semaphorin-4D binding molecules to promote neurogenesis following stroke
ES13787931T ES2882881T3 (es) 2012-05-11 2013-05-10 Uso de moléculas de unión a semaforina-4D para promover la neurogénesis tras un ictus
EA201492067A EA030796B1 (ru) 2012-05-11 2013-05-10 Применение связывающих семафорин-4d молекул для промотирования нейрогенеза после инсульта
AU2013259192A AU2013259192B2 (en) 2012-05-11 2013-05-10 Use of semaphorin-4D binding molecules to promote neurogenesis following stroke
KR1020147034510A KR102105436B1 (ko) 2012-05-11 2013-05-10 뇌졸중 후 신경발생을 촉진시키는 세마포린-４d 결합 분자의 용도
BR112014028160-2A BR112014028160B1 (pt) 2012-05-11 2013-05-10 uso de anticorpo ou de seu fragmento de ligação a antígeno que se liga especificamente à semaforina-4d no aumento de proliferação, diferenciação ou migração de células progenitoras neurais
CN201380037262.9A CN104619341A (zh) 2012-05-11 2013-05-10 脑信号蛋白-4d结合分子在促进中风后的神经发生中的用途
IL235603A IL235603B (en) 2012-05-11 2014-11-10 Use of binding molecules of the semphorin d4 type - to promote neurogenesis after a stroke
ZA2015/01674A ZA201501674B (en) 2012-05-11 2015-03-11 Use of semaphorin-4d binding molecules to promote neurogenesis following stroke

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261646119P 2012-05-11 2012-05-11
US61/646,119 2012-05-11
US13/842,523 US10494440B2 (en) 2012-05-11 2013-03-15 Use of semaphorin-4D binding molecules to promote neurogenesis following stroke
US13/842,523 2013-03-15

Publications (1)

Publication Number Publication Date
WO2013170221A1 true WO2013170221A1 (en) 2013-11-14

Family

ID=49548777

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2013/040661 Ceased WO2013170221A1 (en) 2012-05-11 2013-05-10 Use of semaphorin-4d binding molecules to promote neurogenesis following stroke

Country Status (18)

Country Link
US (1) US10494440B2 (enExample)
EP (1) EP2846831B1 (enExample)
JP (1) JP6218810B2 (enExample)
KR (1) KR102105436B1 (enExample)
CN (2) CN110064054A (enExample)
AU (1) AU2013259192B2 (enExample)
BR (1) BR112014028160B1 (enExample)
CA (1) CA2872928C (enExample)
DK (1) DK2846831T3 (enExample)
EA (1) EA030796B1 (enExample)
ES (1) ES2882881T3 (enExample)
IL (1) IL235603B (enExample)
MX (1) MX358991B (enExample)
NZ (1) NZ630864A (enExample)
PT (1) PT2846831T (enExample)
SG (1) SG11201407416XA (enExample)
WO (1) WO2013170221A1 (enExample)
ZA (1) ZA201501674B (enExample)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9243068B2 (en) 2013-06-25 2016-01-26 Vaccinex, Inc. Combination of SEMA-4D inhibitors and immunomodulators to inhibit tumors and metastases
US9249227B2 (en) 2013-10-21 2016-02-02 Vaccinex, Inc. Use of semaphorin-4D binding molecules for treating neurodegenerative disorders
US9512224B2 (en) 2013-10-10 2016-12-06 Vaccinex, Inc. Use of semaphorin-4D binding molecules for treatment of atherosclerosis
US9605055B2 (en) 2009-05-08 2017-03-28 Vaccinex, Inc. Anti-CD100 antibodies and methods of using the same
CN110325213A (zh) * 2017-02-22 2019-10-11 瓦西尼斯公司 神经退行性或神经炎性疾病中胶质细胞活化的早期检测
US10494440B2 (en) 2012-05-11 2019-12-03 Vaccinex, Inc. Use of semaphorin-4D binding molecules to promote neurogenesis following stroke
US11427634B2 (en) 2017-05-05 2022-08-30 Vaccinex, Inc. Human anti-semaphorin 4D antibody
US11534488B2 (en) 2011-10-11 2022-12-27 Vaccinex, Inc. Use of semaphorin-4D binding molecules for modulation of blood brain barrier permeability

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9090709B2 (en) 2012-03-28 2015-07-28 Vaccinex, Inc. Anti-SEMA4D antibodies and epitopes
US9708601B2 (en) 2012-04-26 2017-07-18 Vaccinex, Inc. Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus
BR112018071686A2 (pt) 2016-04-22 2019-02-19 Vaccinex, Inc. exibição de proteínas integrais de membrana em vírions extracelulares envelopados de poxvírus
WO2018026715A1 (en) 2016-08-02 2018-02-08 Vaccinex, Inc. Improved methods for producing polynucleotide libraries in vaccinia virus/eukaryotic cells
WO2024182357A1 (en) * 2023-02-28 2024-09-06 Brandeis University Compositions and methods for the chronic treatment of epilepsy and epileptogenesis

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5939598A (en) 1990-01-12 1999-08-17 Abgenix, Inc. Method of making transgenic mice lacking endogenous heavy chains
US6635742B1 (en) * 2000-01-25 2003-10-21 Nuvelo, Inc. Antibodies specific for semaphorin-like polypeptides
US20070098707A1 (en) * 2003-12-11 2007-05-03 Genentech, Inc. Methods and Compositions for Inhibiting C-MET Dimerization and Activation
US20080219971A1 (en) * 2007-02-14 2008-09-11 Vaccinex, Inc. Human anti-cd100 antibodies
US20100285036A1 (en) * 2009-05-08 2010-11-11 Vaccinex, Inc. Anti-CD100 Neutralizing Antibodies and Methods of Using the Same
US20120027758A1 (en) * 2003-01-31 2012-02-02 Institut National De La Sante Et De La Recherche Medicale (Inserm) Use of anti-cd100 antibodies

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5070192A (en) 1988-03-23 1991-12-03 The Johns Hopkins University Cloned human topoisomerase i: cdna expression, and use for autoantibody detection
US5154924A (en) * 1989-09-07 1992-10-13 Alkermes, Inc. Transferrin receptor specific antibody-neuropharmaceutical agent conjugates
US6497872B1 (en) 1991-07-08 2002-12-24 Neurospheres Holdings Ltd. Neural transplantation using proliferated multipotent neural stem cells and their progeny
FR2686087A1 (fr) 1992-01-13 1993-07-16 Inst Nat Sante Rech Med Nouvel antigene lymphocytaire, anticorps correspondant et leurs applications.
US5639856A (en) 1993-09-13 1997-06-17 The Regents Of The University Of California Semaphorin gene family
US5595756A (en) 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
US6576754B2 (en) 1995-11-09 2003-06-10 Dana-Farber Cancer Institute CD100 antigen and uses therefor
US20020032315A1 (en) 1997-08-06 2002-03-14 Manuel Baca Anti-vegf antibodies
US6884879B1 (en) 1997-04-07 2005-04-26 Genentech, Inc. Anti-VEGF antibodies
ES2236634T3 (es) 1997-04-07 2005-07-16 Genentech, Inc. Anticuerpos anti-vegf.
WO1998046769A1 (en) 1997-04-11 1998-10-22 Dendreon Corporation Composition and method for inducing an immune response against tumour-related antigens
EP0892047A3 (de) 1997-07-09 2000-03-08 Hoechst Marion Roussel Deutschland GmbH Humanes und murines Semaphorin L
US5968829A (en) 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
US6638501B1 (en) 1997-09-29 2003-10-28 Neurospheres Holdings Ltd. Use of multipotent neural stem cell progeny to augment non-neural tissues
US5958767A (en) 1998-08-14 1999-09-28 The Children's Medical Center Corp. Engraftable human neural stem cells
AU776865B2 (en) 1998-11-10 2004-09-23 University Of Rochester T cells specific for target antigens and methods and vaccines based thereon
JP3787473B2 (ja) 1999-11-30 2006-06-21 独立行政法人科学技術振興機構 セマフォリン受容体
WO2001046384A2 (en) 1999-12-23 2001-06-28 Cornell Research Foundation, Inc. A method for isolating and purifying multipotential neural progenitor cells and multipotential neural progenitor cells
IL159177A0 (en) 2001-06-20 2004-06-01 Prochon Biotech Ltd Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof
EP1365018A1 (en) 2002-05-23 2003-11-26 Institut National De La Sante Et De La Recherche Medicale (Inserm) CD100 semaphorin in myelination
JP4524181B2 (ja) 2002-05-30 2010-08-11 マクロジェニクス，インコーポレーテッド Ｃｄ１６ａ結合タンパク質および免疫障害治療のための使用
RS20150135A1 (sr) 2003-05-30 2015-08-31 Genentech Inc. Tretman sa anti-vegf antitelima
AU2005209331A1 (en) * 2004-01-30 2005-08-11 Peplin Biolipids Pty Ltd Therapeutic and carrier molecules
JP2008504821A (ja) * 2004-07-01 2008-02-21 バイレクシス コーポレイション ベクター・パッケージング細胞系列
US7476724B2 (en) 2004-08-05 2009-01-13 Genentech, Inc. Humanized anti-cmet antibodies
US20060147449A1 (en) 2004-11-15 2006-07-06 Brass Lawrence F Method of using CD100 (or Sema4D) to mediate platelet activation and inflammatory responses
EP1871484A2 (en) 2005-04-07 2008-01-02 Chiron Corporation Sema4d in cancer diagnosis, detection and treatment
JP2007308465A (ja) 2006-05-15 2007-11-29 Boehringer Ingelheim Internatl Gmbh 炎症性疾患、自己免疫疾患又は骨吸収異常の治療方法
WO2009089461A1 (en) 2008-01-10 2009-07-16 Genentech, Inc. Plexind1 agonists and their use
CN102421913A (zh) * 2009-03-13 2012-04-18 宾夕法尼亚大学董事会 Ox40/trail融合蛋白
CA3017298C (en) 2009-05-15 2021-09-28 Irx Therapeutics, Inc. Compositions comprising primary cell-derived biologics for enhancing immune responses in patients
US8834883B2 (en) 2010-06-14 2014-09-16 Vaccinex, Inc. Anti-VEGF antibodies and uses thereof
US9447191B2 (en) 2011-05-13 2016-09-20 National University Corporation Tokyo Medical And Dental University Osteogenesis promoter
CN104168956A (zh) 2011-10-11 2014-11-26 瓦西尼斯公司 臂板蛋白-4d结合分子用于调节血脑屏障渗透性的用途
US8790652B2 (en) 2011-12-06 2014-07-29 Vaccinex, Inc. Use of the combination of semaphorin-4D inhibitory molecules and VEGF inhibitory molecules to inhibit angiogenesis
US9090709B2 (en) 2012-03-28 2015-07-28 Vaccinex, Inc. Anti-SEMA4D antibodies and epitopes
US9708601B2 (en) 2012-04-26 2017-07-18 Vaccinex, Inc. Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus
US10494440B2 (en) 2012-05-11 2019-12-03 Vaccinex, Inc. Use of semaphorin-4D binding molecules to promote neurogenesis following stroke
BR112015032690B1 (pt) 2013-06-25 2020-03-10 Vaccinex, Inc. Uso de moléculas inibidoras de semaforina-4d em combinação com uma terapia imunomoduladora para inibir o crescimento tumoral e metástase
NZ630881A (en) 2013-10-10 2016-03-31 Vaccinex Inc Use of semaphorin-4d binding molecules for treatment of atherosclerosis
NZ630892A (en) 2013-10-21 2016-03-31 Vaccinex Inc Use of semaphorin-4d binding molecules for treating neurodegenerative disorders
WO2018156509A1 (en) * 2017-02-22 2018-08-30 Vaccinex, Inc. Early detection of glial cell activation in neurodegenerative or neuroinflammatory diseases

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683195B1 (enExample) 1986-01-30 1990-11-27 Cetus Corp
US5939598A (en) 1990-01-12 1999-08-17 Abgenix, Inc. Method of making transgenic mice lacking endogenous heavy chains
US6635742B1 (en) * 2000-01-25 2003-10-21 Nuvelo, Inc. Antibodies specific for semaphorin-like polypeptides
US20120027758A1 (en) * 2003-01-31 2012-02-02 Institut National De La Sante Et De La Recherche Medicale (Inserm) Use of anti-cd100 antibodies
US20070098707A1 (en) * 2003-12-11 2007-05-03 Genentech, Inc. Methods and Compositions for Inhibiting C-MET Dimerization and Activation
US20080219971A1 (en) * 2007-02-14 2008-09-11 Vaccinex, Inc. Human anti-cd100 antibodies
US20100285036A1 (en) * 2009-05-08 2010-11-11 Vaccinex, Inc. Anti-CD100 Neutralizing Antibodies and Methods of Using the Same

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
"DNA Cloning", vol. I,II, 1985
"Immobilized Cells And Enzymes", 1986, IRL PRESS
DIEFFENBACHDVEKSLER: "PCR Primer", 2003, COLD SPRING HARBOR PRESS
FRESHNEY: "Culture Of Animal Cells", 1987, ALAN R. LISS, INC.
GAIT: "Transcription And Translation", 1984
HAMERS-CASTERMAN ET AL., NATURE, vol. 363, 1993, pages 446 - 448
HARLOW ET AL.: "Antibodies: A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY PRESS, pages: 27 - 28
SAMBROOK ET AL.: "Molecular Cloning A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 1992, COLD SPRINGS HARBOR LABORATORY
See also references of EP2846831A4

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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US9605055B2 (en) 2009-05-08 2017-03-28 Vaccinex, Inc. Anti-CD100 antibodies and methods of using the same
US9676840B2 (en) 2009-05-08 2017-06-13 Vaccinex, Inc. Anti-CD100 neutralizing antibodies and methods of using the same
US11534488B2 (en) 2011-10-11 2022-12-27 Vaccinex, Inc. Use of semaphorin-4D binding molecules for modulation of blood brain barrier permeability
US10494440B2 (en) 2012-05-11 2019-12-03 Vaccinex, Inc. Use of semaphorin-4D binding molecules to promote neurogenesis following stroke
US10526414B2 (en) 2013-06-25 2020-01-07 Vaccinex, Inc. Use of anti-semaphorin-4D antibodies in combination with an immune modulating therapy to inhibit tumor growth and metastases
US9828435B2 (en) 2013-06-25 2017-11-28 Vaccinex, Inc. Use of antibodies or antigen-binding fragments thereof that specifically bind semaphorin-4D to increase tumor infiltrating leukocyte frequency
US9243068B2 (en) 2013-06-25 2016-01-26 Vaccinex, Inc. Combination of SEMA-4D inhibitors and immunomodulators to inhibit tumors and metastases
US11078295B2 (en) 2013-06-25 2021-08-03 Vaccinex, Inc. Use of semaphorin-4D inhibitory molecules with an immune modulating therapy to inhibit tumor growth and metastases
US9512224B2 (en) 2013-10-10 2016-12-06 Vaccinex, Inc. Use of semaphorin-4D binding molecules for treatment of atherosclerosis
US9249227B2 (en) 2013-10-21 2016-02-02 Vaccinex, Inc. Use of semaphorin-4D binding molecules for treating neurodegenerative disorders
US9598495B2 (en) 2013-10-21 2017-03-21 Vaccinex, Inc. Use of semaphorin-4D binding molecules for treating neurodegenerative disorders
US10800853B2 (en) 2013-10-21 2020-10-13 Vaccinex, Inc. Use of semaphorin-4D binding molecules for treating neurodegenerative disorders
US10385136B2 (en) 2013-10-21 2019-08-20 Vaccinex, Inc. Use of semaphorin-4D binding molecules for treating neurodegenerative disorders
CN106029093A (zh) * 2013-10-21 2016-10-12 瓦西尼斯公司 脑信号蛋白-4d结合分子治疗神经变性疾病的用途
CN106029093B (zh) * 2013-10-21 2023-03-28 瓦西尼斯公司 脑信号蛋白-4d结合分子治疗神经变性疾病的用途
CN110325213A (zh) * 2017-02-22 2019-10-11 瓦西尼斯公司 神经退行性或神经炎性疾病中胶质细胞活化的早期检测
EP3585435A4 (en) * 2017-02-22 2020-12-16 Vaccinex, Inc. EARLY DETECTION OF GLIAL CELL ACTIVATION IN NEURODEGENERATIVE OR NEURO-INFLAMMATORY DISEASES
AU2018225493B2 (en) * 2017-02-22 2025-03-06 Vaccinex, Inc. Early detection of glial cell activation in neurodegenerative or neuroinflammatory diseases
IL267940B2 (en) * 2017-02-22 2025-04-01 Vaccinex Inc Early detection of glial cell activation in neurodegenerative or neuroinflammatory diseases
US11427634B2 (en) 2017-05-05 2022-08-30 Vaccinex, Inc. Human anti-semaphorin 4D antibody
US12006365B2 (en) 2017-05-05 2024-06-11 Vaccinex, Inc. Human anti-semaphorin 4D antibody

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CN110064054A (zh) 2019-07-30
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CA2872928C (en) 2021-02-16
BR112014028160B1 (pt) 2021-01-12
KR102105436B1 (ko) 2020-04-29
EA201492067A1 (ru) 2015-05-29
JP2015517502A (ja) 2015-06-22
ZA201501674B (en) 2021-06-30
DK2846831T3 (en) 2021-10-11
CN104619341A (zh) 2015-05-13
EA030796B1 (ru) 2018-09-28
IL235603B (en) 2020-01-30
US10494440B2 (en) 2019-12-03
ES2882881T3 (es) 2021-12-03
AU2013259192A1 (en) 2014-11-27
MX358991B (es) 2018-08-31
EP2846831A4 (en) 2015-11-18
IL235603A0 (en) 2015-01-29
EP2846831A1 (en) 2015-03-18
NZ630864A (en) 2017-03-31
EP2846831B1 (en) 2021-07-07
MX2014013676A (es) 2015-02-05
AU2013259192B2 (en) 2018-02-22
PT2846831T (pt) 2021-08-19
US20130302320A1 (en) 2013-11-14
CA2872928A1 (en) 2013-11-14
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