WO2013099378A1 - Promoteur de production de collagène - Google Patents

Promoteur de production de collagène Download PDF

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Publication number
WO2013099378A1
WO2013099378A1 PCT/JP2012/074763 JP2012074763W WO2013099378A1 WO 2013099378 A1 WO2013099378 A1 WO 2013099378A1 JP 2012074763 W JP2012074763 W JP 2012074763W WO 2013099378 A1 WO2013099378 A1 WO 2013099378A1
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WIPO (PCT)
Prior art keywords
collagen production
extract
collagen
production promoter
button
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PCT/JP2012/074763
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English (en)
Japanese (ja)
Inventor
時也 横井
伊藤　明
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株式会社資生堂
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Publication of WO2013099378A1 publication Critical patent/WO2013099378A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material

Definitions

  • the present invention relates to a collagen production promoter, and particularly to a collagen production promoter that has an excellent collagen production promotion action, is safe, and is suitable for blending in foods and beverages and cosmetics.
  • the decrease in skin elasticity is affected by the amount of collagen produced by fibroblasts present in the dermis. That is, the skin with a large amount of collagen production is thick and rich in elasticity, but when the collagen production amount is reduced, the skin thickness is reduced and the skin tension is also reduced. In addition, it is said that when the elastin fibers and oxytalan fibers that support the mechanical structure of the skin are deteriorated, the skin tension is remarkably reduced.
  • Patent Document 8 The plant or its extract has an action of inhibiting disaccharide-degrading enzymes and is effective in preventing and treating diabetes and eliminating obesity (Patent Literature) 5) Cell activation, antioxidant, melanin production inhibitory effect (Patent Document 6), heparanase activity inhibitory action, effective in preventing and improving wrinkles (Patent Document 7), ceramide synthesis promotion It is known that there is an action (Patent Document 8).
  • Japanese Patent No. 2732958 Japanese Patent Laid-Open No. 4-346936
  • Japanese Patent No. 25333339 Japanese Patent Laid-Open No. 63-166837
  • Japanese Patent Publication No. 6-102626 JP 7-505378 A Japanese Patent Laid-Open No. 2003-26694 Japanese Patent Laid-Open No. 2004-26697 International Publication No. WO09 / 123215 JP 2005-194239 A
  • the present inventor has intensively studied a substance having an action of strongly promoting the collagen production of dermal fibroblasts, and as a result, has found that button bowfish (Peucedanum japonicum Thunb.) Has an excellent collagen production promoting ability. It was.
  • the present invention is characterized by comprising a plant body of a button bud (Peucedanum japonicum Thunb.) Belonging to the genus Pemedumum (Peucedanum L.) of the family Umbelliferae, or an extract of the organic solvent or a hydrous organic solvent. It is a collagen production promoter.
  • the collagen production promoter of the present invention is excellent in the effect of promoting collagen production and is safe. Therefore, according to the collagen production promoter of the present invention, it is possible to promote collagen production and maintain the amount of collagen, improve the reduction of skin agglomeration, promote skin wound healing, and result from lack of collagen It is effective in improving various symptoms.
  • the collagen production promoter of the present invention has excellent collagen production promotion ability. Therefore, the collagen production promoter of the present invention is blended with pharmaceuticals (for example, external preparations for skin and internal medicines), quasi drugs, cosmetics, and foods and beverages (for example, supplements and beverages) and has a collagen production promoting effect. It is preferable to use food and drinks.
  • pharmaceuticals for example, external preparations for skin and internal medicines
  • quasi drugs for example, cosmetics
  • foods and beverages for example, supplements and beverages
  • the button bow pea Used in the present invention is a plant belonging to the genus Umbelliferae (Peucedanum L.) and is also referred to as “long life grass”. It is an evergreen perennial that grows naturally in harsh natural conditions such as the cliffs on the coast of the Yaeyama Islands in Okinawa and the rocky limestone rocks.
  • the buttonfish used in the present invention is known to have a cell activation effect, an antioxidant effect, a ceramide synthesis promoting effect, etc., but there has never been a report that it has a collagen production promoting effect. This has been found for the first time by the present inventors.
  • the button bow fuu used in the present invention may be derived from any part and is not particularly limited. For example, leaves, stems, roots, whole plants, or a mixture thereof can be used.
  • the button bow fuu to be used in the present invention a plant body or its (water-containing) organic solvent extract is used.
  • the plant body is not particularly limited, but is not particularly limited, for example, as long as the raw material button bow is processed, for example, ground product, dry powder, pulverized product, juice, crushed Product, chemically treated product, enzyme treated product, and particularly preferably dry powder.
  • the extract of the button fountain used in the present invention can be obtained by drying or pulverizing the button fountain, for example, its leaves, stems, roots or whole plants, or a mixture thereof, and then extracting them with a solvent. Particularly preferred is whole grass.
  • the extraction may be performed at room temperature, but the extraction can be promoted by heating, stirring and heating under reflux as necessary.
  • the obtained extract can be used as it is or after being appropriately subjected to treatment such as filtration, concentration, and decolorization. It is also possible to remove the solvent once and redissolve it in a solvent different from the solvent used for extraction.
  • the obtained extract can be further purified by activated carbon, column chromatography, or the like.
  • alcohols such as ethanol, 1,3-butanediol, propylene glycol and dipropylene glycol or hydrated products thereof can be used. It is preferred to select butanediol.
  • the water content is, for example, 20 to 80% by mass.
  • the obtained extract can be used as it is or after being appropriately subjected to treatment such as filtration, concentration and decolorization. It is also possible to remove the solvent once and redissolve it in a solvent different from the solvent used for extraction.
  • the obtained extract can be further purified by activated carbon, column chromatography, or the like. In addition to using whole grass as an extraction site, specific sites (leaves, stems, roots, etc.) may be collected and extracted.
  • the collagen production promoter of the present invention is characterized in that it contains a button bud plant or its (water-containing) organic solvent extract, but may contain other various components within a range not impairing the effects of the present invention. I can do it.
  • the collagen production promoter of the present invention is used as a skin external preparation having a collagen production promoting action by blending with a skin external base, or as a functional food having a collagen production promoting action by blending with food or drink. Used as an improvement agent for beam reduction.
  • external preparations for skin can be suitably used particularly in the fields of cosmetics, pharmaceuticals, quasi drugs and the like.
  • a plant extract is preferable, and the blending amount of the plant extract is usually 0.00001% by mass or more, preferably 0 as the dry residue of the button bud extract component. 0.0001% by mass or more. If the blending amount is too small, the effect is not sufficiently exhibited.
  • the upper limit is not particularly limited as long as the effect of the present invention is not impaired. However, even if it is excessively mixed, a remarkable effect commensurate with the increase in amount cannot be obtained, and there are cases where adverse effects are exerted on the formulation design and usability. For this reason, it is usually preferable to blend at 10% by mass or less, more preferably 1% by mass or less.
  • the blending amount of the plant extract is particularly preferably 0.0001 to 0.001% by mass.
  • the skin external preparation containing the collagen production promoter of the present invention is produced by blending the collagen production promoter according to the present invention with a skin external base.
  • the external preparation for skin is a component that is usually used for external preparations for skin such as cosmetics and pharmaceuticals, for example, moisturizer, antioxidant, oily component, ultraviolet ray, as long as the effects of the present invention are not impaired.
  • Absorbers, surfactants, thickeners, alcohols, powder components, colorants, aqueous components, water, plant extracts, various skin nutrients, and the like can be appropriately blended as necessary.
  • the external preparation for skin containing the collagen production promoter of the present invention may be any ophthalmic ointment, cream, emulsion, lotion, pack, bath preparation, etc. as long as it is used for conventional external preparations for skin, and the dosage form is not particularly limited.
  • the functional food which has the improvement effect of the reduction
  • the blending amount (dry mass) of the plant body or its extract can be appropriately determined according to the type, purpose, form, usage method, and the like. For example, in the case of tablets or capsules in the total amount of food and drink, 1 to 90% by mass is preferable.
  • a form of food and drink for example, it can be arbitrarily formed into a granular shape, a granular shape, a paste shape, a gel shape, a solid shape, or a liquid shape.
  • These include various known substances that are recognized to be contained in foods and drinks, such as binders, disintegrants, thickeners, dispersants, reabsorption accelerators, flavoring agents, buffers, and surfactants. Excipients such as solubilizers, preservatives, emulsifiers, tonicity agents, stabilizers and pH adjusters can be included as appropriate.
  • the present invention will be described in more detail with reference to the following examples, but the present invention is not limited thereto. Unless otherwise specified, the amount is shown in mass%. Initially, the preparation method of the plant extract used in the present Example, the test method regarding a collagen production promotion effect, and its result are demonstrated.
  • test sample 1 10% of 50% ethanol was added to 18.5g of dried pulverized leaves and stems of button pea (Peucedanum japonicum), extracted at room temperature for 1 week, left at 4 ° C overnight, filtered and insoluble. Removed. The obtained filtrate is called 50% ethanol extract. Furthermore, the solid obtained by freeze-drying will be referred to as 50% ethanol-extracted dry product. The yield of the obtained 50% ethanol-extracted dried product was 5.08 g (yield: 27.5%).
  • Test sample 2 10 times the amount of distilled water was added to 21.1 g of dry ground pulverized roots of Peucedanum japonicum, extracted at room temperature for 1 week, left at 4 ° C. overnight, and filtered to remove insolubles. .
  • the obtained filtrate is called a water extract.
  • the solid obtained by freeze-drying will be referred to as a water-extracted dried product.
  • the yield of the obtained water-extracted dried product was 5.02 g (yield; 23.8%).
  • the amount of type I collagen secreted into the culture supernatant was measured using enzyme immunosorbent assay (ELISA). That is, 100 ⁇ l of the standard antibody solution was added to the anti-PIP monoclonal antibody plate, and 20 ⁇ l of the standard solution prepared in advance was added to the culture supernatant and reacted at 37 ° C. for 3 hours. Discard the reaction solution, wash 4 times with PBS, add 100 ⁇ l each of substrate solution (3,3 ', 5,5' tetramethylbenzidine solution) and react at room temperature for 15 minutes to obtain antibody plate / PIP antigen / standard antibody. I made a conjugate.
  • ELISA enzyme immunosorbent assay
  • Collagen production promotion rate was computed using the following formula
  • Collagen production acceleration rate (%) (total collagen amount produced by cells added with test sample / number of cells in group added test sample) ⁇ (total collagen amount produced by cells not added with test sample / test) Number of cells in the group to which no sample was added) ⁇ 100 The test used Paired-t-test.
  • FIG. 1 shows the result of comparison of the total amount of collagen produced when the dried solids prepared in Test Samples 1 and 2 were added so that the final concentration was 0.001%.
  • the total amount of collagen production is shown as a value when the control is 100.
  • 50% ethanol-extracted dried product and water-extracted dried product of button bowfish 50% ethanol-dried product produced the highest amount of total collagen, whereas 139% compared to the control. The water-extracted dried product has no effect.
  • the amount of collagen produced per fibroblast was compared for the amount of collagen produced by 0.001% of the dried solid prepared in test samples 1 and 2.
  • the 50% ethanol-extracted dried product had a significant collagen production promoting action of 158.4%, but the water-extracted dried product had no effect.
  • collagen production promotion rate As a result of investigating the concentration dependency of 50% ethanol-extracted dried product corresponding to the test sample 1 with respect to the amount of collagen produced per fibroblast (collagen production promotion rate), as shown in FIG.
  • the collagen production promotion rates of 0.0001%, 0.001%, and 0.01% were significantly increased by 173.8%, 158.4%, and 137%, respectively.
  • formulation examples of collagen production promoters according to the present invention in various dosage forms will be described as formulation examples. Needless to say, the present invention is not limited by these formulation examples and is specified by the scope of claims.
  • Formulation Formula 1 (Lotion) Mass% Trimethylglycine 1.0 Collagen production promoter 0.01 (0.0001 mass% as dry solid content) (Button Bow / 50% ethanol extract) Glycerin 1.0 1,3-butylene glycol 5.0 Sodium alginate 0.1 Ethyl alcohol 5.0 Polyoxyethylene polyoxypropylene decyl tetradecyl ether 0.2 Sodium hexametaphosphate Appropriate amount Citric acid Appropriate amount Sodium citrate Appropriate amount Phenoxyethanol Appropriate perfume Appropriate amount Purified water Residue
  • Formulation Example 4 (milky lotion) Dipotassium glycyrrhizinate 0.05 Tocopherol acetate 0.5 Collagen production promoter 0.1 (dry solid content) (Button Bow / 50% ethanol extract) Sodium L-glutamate 0.05 Fennel extract 0.1 Yeast extract 0.1 Giant extract 0.1 Hydroxypropyl- ⁇ -cyclodextrin 0.1 Glycerin 6.0 1,3-butylene glycol 5.0 Polyoxyethylene methyl glucoside 3.0 Sunflower oil 1.0 Squalane 2.0 Isododecane 4.0 Dimethylpolysiloxane 3.0 Xanthan gum 0.1 Carboxyvinyl polymer 0.1 Acrylic acid / alkyl methacrylate copolymer 0.1 Ethyl alcohol 5.0 Potassium hydroxide Appropriate amount Sodium hexametaphosphate Appropriate amount Bengala Appropriate amount Yellow iron oxide Appropriate amount Ethylparaben Appropriate perfume Appropri
  • Formulation Example 5 (Daytime emulsion) Dipotassium glycyrrhizinate 0.1 Collagen production promoter 0.1 (0.001% by mass as dry solid content) (Button Bow Fufu / 50% -1,3 butanediol extract) Tocopherol acetate 0.1 1,3-butylene glycol 5.0 Squalane 0.5 Isododecane 10.0 Isohexadecane 25.0 Dimethylpolysiloxane 2.0 Polyoxyethylene / methylpolysiloxane copolymer 1.5 Trimethylsiloxysilicic acid 1.0 4-t-Butyl-4'-methoxydibenzoylmethane 1.0 2-Ethylhexyl paramethoxycinnamate 5.0 Di-2-methoxycinnamic acid mono-2-ethylglyceryl glyceryl 1.0 Silicone coated fine particle titanium oxide 4.0 Dimethyl distearyl ammonium hectorite 0.5 Spherical poly
  • Formulation Example 6 (milky lotion) L-Arginine 0.1 Royal Jelly Extract 0.1 Yeast extract 0.1 Collagen production promoter 0.1 (0.001% by mass as dry solid content) (Button Bow / 50% ethanol extract / 50% -1,3 butanediol replacement solution) Stearyl glycyrrhetinate 0.05 Tocopherol acetate 0.1 Acetylated sodium hyaluronate 0.1 Glycerin 5.0 Dipropylene glycol 7.0 Polyethylene glycol 1500 2.0 Liquid paraffin 7.0 Vaseline 3.0 Behenyl alcohol 1.0 Batyl alcohol 2.0 Jojoba oil 1.0 Stearic acid 0.5 Isostearic acid 0.5 Behenic acid 0.5 Tetra-2-ethylhexanoic acid pentaerythritol 3.0 Cetyl 2-ethylhexanoate 3.0 Glycerol monostearate 1.0 Polyoxyethylene glycerol monostearate 1.0 Carboxyvinyl polymer

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
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  • Public Health (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract

L'invention concerne un nouveau promoteur de production de collagène d'origine végétale ayant une excellente action de promotion de la production de collagène. L'invention comprend un extrait de la plante Peucedanum japonicum Thunb appartenant au genre Peucedanum L. de la famille des Umbelliferae, ou d'un solvant organique ou d'un solvant organique à teneur en eau de celui-ci.
PCT/JP2012/074763 2011-12-27 2012-09-26 Promoteur de production de collagène WO2013099378A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011-285155 2011-12-27
JP2011285155A JP2013133317A (ja) 2011-12-27 2011-12-27 コラーゲン産生促進剤

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WO2013099378A1 true WO2013099378A1 (fr) 2013-07-04

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TW (1) TW201328719A (fr)
WO (1) WO2013099378A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103610630A (zh) * 2013-12-13 2014-03-05 扈嘉正 一种具有祛皱修复功能的化妆用膏剂

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6045164B2 (ja) * 2012-03-27 2016-12-14 小林製薬株式会社 長命草ポリフェノール並びにビタミンｅ及び／又はビタミンｃを含む組成物
JP6211558B2 (ja) * 2015-05-14 2017-10-11 株式会社東洋新薬 美容組成物
CN116867474A (zh) * 2021-03-19 2023-10-10 株式会社资生堂 双层化妆品

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002539229A (ja) * 1999-03-18 2002-11-19 ユニリーバー・ナームローゼ・ベンノートシヤープ 皮膚化粧品組成物
JP2004026697A (ja) * 2002-06-25 2004-01-29 Noevir Co Ltd 細胞賦活剤、抗酸化剤、メラニン産生抑制剤及び皮膚外用剤
JP2004075627A (ja) * 2002-08-21 2004-03-11 Maruzen Pharmaceut Co Ltd コラーゲン産生促進剤、ホスホリパーゼａ２活性阻害剤、及び血小板凝集抑制剤、並びに皮膚外用剤及び美容飲食品
JP2011213699A (ja) * 2010-04-02 2011-10-27 Kinki Univ デイジー花部から得られるコラーゲン産生促進作用を有する皮膚外用剤

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002539229A (ja) * 1999-03-18 2002-11-19 ユニリーバー・ナームローゼ・ベンノートシヤープ 皮膚化粧品組成物
JP2004026697A (ja) * 2002-06-25 2004-01-29 Noevir Co Ltd 細胞賦活剤、抗酸化剤、メラニン産生抑制剤及び皮膚外用剤
JP2004075627A (ja) * 2002-08-21 2004-03-11 Maruzen Pharmaceut Co Ltd コラーゲン産生促進剤、ホスホリパーゼａ２活性阻害剤、及び血小板凝集抑制剤、並びに皮膚外用剤及び美容飲食品
JP2011213699A (ja) * 2010-04-02 2011-10-27 Kinki Univ デイジー花部から得られるコラーゲン産生促進作用を有する皮膚外用剤

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
OKINAWA INDUSTRIAL TECHNOLOGY CENTER KENKYU HOKOKU, no. 8, September 2006 (2006-09-01), pages 65 - 70 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103610630A (zh) * 2013-12-13 2014-03-05 扈嘉正 一种具有祛皱修复功能的化妆用膏剂

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