CN116867474A - 双层化妆品 - Google Patents
双层化妆品 Download PDFInfo
- Publication number
- CN116867474A CN116867474A CN202280015878.5A CN202280015878A CN116867474A CN 116867474 A CN116867474 A CN 116867474A CN 202280015878 A CN202280015878 A CN 202280015878A CN 116867474 A CN116867474 A CN 116867474A
- Authority
- CN
- China
- Prior art keywords
- cosmetic
- oil
- acid
- examples
- resorcinol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000002537 cosmetic Substances 0.000 title claims abstract description 93
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 18
- VNXWANZMRATDQM-UHFFFAOYSA-N 2-(2-phenylethyl)benzene-1,3-diol Chemical compound OC1=CC=CC(O)=C1CCC1=CC=CC=C1 VNXWANZMRATDQM-UHFFFAOYSA-N 0.000 claims abstract description 16
- YRJKYHIIYRGTCC-UHFFFAOYSA-M potassium;2-hydroxy-4-methoxybenzoate Chemical compound [K+].COC1=CC=C(C([O-])=O)C(O)=C1 YRJKYHIIYRGTCC-UHFFFAOYSA-M 0.000 claims abstract description 16
- 229940067599 ascorbyl glucoside Drugs 0.000 claims abstract description 15
- 239000008346 aqueous phase Substances 0.000 claims abstract description 14
- IFVWLEMMYISKHW-UHFFFAOYSA-N 4-(2-methylpropyl)benzene-1,3-diol Chemical compound CC(C)CC1=CC=C(O)C=C1O IFVWLEMMYISKHW-UHFFFAOYSA-N 0.000 claims abstract description 13
- MLSJBGYKDYSOAE-DCWMUDTNSA-N L-Ascorbic acid-2-glucoside Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C1O MLSJBGYKDYSOAE-DCWMUDTNSA-N 0.000 claims abstract description 13
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims abstract description 13
- 239000012071 phase Substances 0.000 claims abstract description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 16
- 239000003814 drug Substances 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 150000005846 sugar alcohols Polymers 0.000 claims description 11
- 239000004094 surface-active agent Substances 0.000 claims description 11
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 10
- 235000011187 glycerol Nutrition 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 6
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 claims description 5
- 235000005152 nicotinamide Nutrition 0.000 claims description 5
- 239000011570 nicotinamide Substances 0.000 claims description 5
- 229960003966 nicotinamide Drugs 0.000 claims description 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 4
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 4
- 229920005862 polyol Polymers 0.000 claims description 4
- 150000003077 polyols Chemical class 0.000 claims description 4
- 239000000600 sorbitol Substances 0.000 claims description 4
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 3
- CCLARULDIPFTCP-BOYHRMMASA-N (2r,3r,4r,5s)-heptane-1,2,3,4,5,6-hexol Chemical compound CC(O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO CCLARULDIPFTCP-BOYHRMMASA-N 0.000 claims description 2
- 229940105990 diglycerin Drugs 0.000 claims description 2
- 238000000926 separation method Methods 0.000 abstract description 6
- -1 amide compound Chemical class 0.000 description 63
- 239000003921 oil Substances 0.000 description 49
- 235000019198 oils Nutrition 0.000 description 49
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 17
- 239000000843 powder Substances 0.000 description 14
- 230000000694 effects Effects 0.000 description 13
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 12
- 229920000642 polymer Polymers 0.000 description 12
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 11
- 239000004166 Lanolin Substances 0.000 description 11
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- 229940039717 lanolin Drugs 0.000 description 11
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 10
- MTHSVFCYNBDYFN-UHFFFAOYSA-N anhydrous diethylene glycol Natural products OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 10
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- 150000001298 alcohols Chemical class 0.000 description 9
- 229940079593 drug Drugs 0.000 description 9
- 239000001993 wax Substances 0.000 description 9
- 235000017788 Cydonia oblonga Nutrition 0.000 description 8
- 239000000284 extract Substances 0.000 description 8
- 229960004050 aminobenzoic acid Drugs 0.000 description 7
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 7
- 238000011156 evaluation Methods 0.000 description 7
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 6
- 239000006096 absorbing agent Substances 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 6
- 239000000839 emulsion Substances 0.000 description 6
- 239000002304 perfume Substances 0.000 description 6
- 239000000049 pigment Substances 0.000 description 6
- 238000010792 warming Methods 0.000 description 6
- 230000002087 whitening effect Effects 0.000 description 6
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 5
- 229920002472 Starch Polymers 0.000 description 5
- 239000008107 starch Substances 0.000 description 5
- 235000019698 starch Nutrition 0.000 description 5
- DSSYKIVIOFKYAU-OIBJUYFYSA-N (S)-camphor Chemical compound C1C[C@]2(C)C(=O)C[C@H]1C2(C)C DSSYKIVIOFKYAU-OIBJUYFYSA-N 0.000 description 4
- ZCTQGTTXIYCGGC-UHFFFAOYSA-N Benzyl salicylate Chemical compound OC1=CC=CC=C1C(=O)OCC1=CC=CC=C1 ZCTQGTTXIYCGGC-UHFFFAOYSA-N 0.000 description 4
- 229920000161 Locust bean gum Polymers 0.000 description 4
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 235000001014 amino acid Nutrition 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- 229960005070 ascorbic acid Drugs 0.000 description 4
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 4
- 235000010980 cellulose Nutrition 0.000 description 4
- 229920002678 cellulose Polymers 0.000 description 4
- 239000001913 cellulose Substances 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 4
- 235000010420 locust bean gum Nutrition 0.000 description 4
- 239000000711 locust bean gum Substances 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- KVWWIYGFBYDJQC-UHFFFAOYSA-N methyl dihydrojasmonate Chemical compound CCCCCC1C(CC(=O)OC)CCC1=O KVWWIYGFBYDJQC-UHFFFAOYSA-N 0.000 description 4
- 239000008177 pharmaceutical agent Substances 0.000 description 4
- 239000011347 resin Substances 0.000 description 4
- 229920005989 resin Polymers 0.000 description 4
- 239000003760 tallow Substances 0.000 description 4
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 4
- 229960000401 tranexamic acid Drugs 0.000 description 4
- YCVPRTHEGLPYPB-VOTSOKGWSA-N trans-pinosylvin Chemical compound OC1=CC(O)=CC(\C=C\C=2C=CC=CC=2)=C1 YCVPRTHEGLPYPB-VOTSOKGWSA-N 0.000 description 4
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 3
- 244000236931 Cydonia oblonga Species 0.000 description 3
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 3
- 241000402754 Erythranthe moschata Species 0.000 description 3
- 229920002907 Guar gum Polymers 0.000 description 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 240000007472 Leucaena leucocephala Species 0.000 description 3
- 235000010643 Leucaena leucocephala Nutrition 0.000 description 3
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 3
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 3
- 229920001615 Tragacanth Polymers 0.000 description 3
- 229940022663 acetate Drugs 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 150000001299 aldehydes Chemical class 0.000 description 3
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 3
- 235000010323 ascorbic acid Nutrition 0.000 description 3
- 239000011668 ascorbic acid Substances 0.000 description 3
- AEMOLEFTQBMNLQ-UHFFFAOYSA-N beta-D-galactopyranuronic acid Natural products OC1OC(C(O)=O)C(O)C(O)C1O AEMOLEFTQBMNLQ-UHFFFAOYSA-N 0.000 description 3
- 239000010495 camellia oil Substances 0.000 description 3
- 235000014113 dietary fatty acids Nutrition 0.000 description 3
- 239000004205 dimethyl polysiloxane Substances 0.000 description 3
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
- 229930195729 fatty acid Natural products 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- 235000010417 guar gum Nutrition 0.000 description 3
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- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 3
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- 229960003512 nicotinic acid Drugs 0.000 description 3
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- ZQBAKBUEJOMQEX-UHFFFAOYSA-N phenyl salicylate Chemical compound OC1=CC=CC=C1C(=O)OC1=CC=CC=C1 ZQBAKBUEJOMQEX-UHFFFAOYSA-N 0.000 description 3
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Abstract
[课题]提供一种双层化妆品,其具有优异的双层稳定性、分离性良好并且粘腻等使用性良好。[解决方案]使用一种双层化妆品,其含有:(A)选自由4‑甲氧基水杨酸钾盐、烟酰胺、抗坏血酸葡糖甙、苯乙基间苯二酚和4‑异丁基间苯二酚组成的组中的1种以上的药剂;(B)水相;和(C)油相。
Description
技术领域
本发明涉及双层化妆品。
背景技术
温感化妆品能够给使用者带来舒适的温感,是冬季气温低的时期特别受欢迎的化妆品。但是,温感化妆品由于大量配合了具有温感作用的保湿剂种类,因此,用于面部时的粘腻强、另外在不冲洗掉的使用用途中对肌肤的刺激也大。进而,为了确保温感效果而成为在制剂中几乎不含水的配方,因此,可配合的提取物、作为有效成分的药剂等的配合变得困难。
迄今为止,已知含有凝血酸的温感化妆品,该凝血酸大多作为改善皮肤粗糙或美白剂等而被配合(参照专利文献1),但含有除凝血酸以外成为有效成分的药剂的温感化妆品完全不为人所知。另外,关于含有除凝血酸以外成为有效成分的药剂且无粘腻的双层化妆品,迄今为止也完全不为人所知。
现有技术文献
专利文献
专利文献1:国际公开第2019/230579号公报
发明内容
本发明人等令人吃惊地发现,通过使水相与油相的双层化妆品含有特定的药剂,能够实现具有优异的双层稳定性、分离性良好且粘腻等使用性良好的双层化妆品。本发明是基于这些见解而做出的。
根据本发明,提供如下发明。
(1)一种双层化妆品,其含有:
(A)选自由4-甲氧基水杨酸钾盐、烟酰胺、抗坏血酸葡糖甙、苯乙基间苯二酚和4-异丁基间苯二酚组成的组中的1种以上的药剂;
(B)水相;和
(C)油相。
(2)根据(1)所述的化妆品,其中,前述(B)水相中的水的配合量相对于化妆品的总量为10质量%以下。
(3)根据(1)或(2)所述的化妆品,其中,前述(B)水相中包含多元醇。
(4)根据(3)所述的化妆品,其中,前述多元醇包含选自甘油、一缩二丙二醇、一缩二甘油、山梨糖醇、甲基葡糖醇聚醚-10和1,3-丁二醇中的1种以上。
(5)根据(3)或(4)所述的化妆品,其中,前述多元醇的配合量相对于化妆品的总量为40~70质量%。
(6)根据(1)~(5)中任一项所述的化妆品,其中,化妆品为温感化妆品。
(7)根据(1)~(6)中任一项所述的化妆品,其中,前述(A)药剂为4-甲氧基水杨酸钾盐、烟酰胺或苯乙基间苯二酚。
(8)根据(1)~(6)中任一项所述的化妆品,其中,
前述(A)药剂为4-甲氧基水杨酸钾盐、烟酰胺、抗坏血酸葡糖甙或4-异丁基间苯二酚,且
4-甲氧基水杨酸钾盐、烟酰胺、抗坏血酸葡糖甙或4-异丁基间苯二酚的配合量相对于化妆品的总量为0.25~6质量%。
(9)根据(1)~(6)中任一项所述的化妆品,其中,
前述(A)药剂为苯乙基间苯二酚,且
所述苯乙基间苯二酚的配合量相对于化妆品的总量为5质量%以下。
(10)根据(1)~(9)中任一项所述的化妆品,其中,
表面活性剂的配合量相对于化妆品的总量低于0.01质量%。
通过使用本发明的双层化妆品,在能够提供具有优异的双层稳定性、分离性良好且粘腻等使用性良好的双层化妆品的方面是有利的。
具体实施方式
本发明提供一种双层化妆品,其含有:
(A)选自由4-甲氧基水杨酸钾盐、烟酰胺、抗坏血酸葡糖甙、苯乙基间苯二酚和4-异丁基间苯二酚组成的组中的1种以上的药剂;
(B)水相;和
(C)油相。
<药剂>
本发明的双层化妆品中含有的药剂为选自由4-甲氧基水杨酸钾盐、烟酰胺、抗坏血酸葡糖甙、苯乙基间苯二酚和4-异丁基间苯二酚组成的组中的1种以上的药剂。
4-甲氧基水杨酸钾盐为水杨酸衍生物的1种,是具有抑制酪氨酸酶的活性、抑制黑色素生成等作用的化合物。
烟酰胺也被称为尼克酰胺、烟碱酰胺,为烟酸的衍生物,是烟酸(维生素B3/尼克酸)的酰胺化合物。烟酰胺是水溶性维生素,是维生素B族之一的公知物质,可以由天然物(米糠等)中提取,或者也可以通过公知的方法合成。例如,可以使用日本药典第十八修订中所记载的物质。
抗坏血酸葡糖甙没有特别限定,优选为L-抗坏血酸葡糖甙,L-抗坏血酸葡糖甙是抗坏血酸衍生物之一,是将淀粉液化液和L-抗坏血酸通过环糊精葡萄糖基转移酶的糖转移反应而生成的物质。涂布于皮肤后快速地经皮吸收,在生物体内转化为抗坏血酸(维生素C),因此,被广泛用于需要美白效果的皮肤外用剂。
苯乙基间苯二酚是以作为常绿针叶树的欧洲赤松中所含的赤松素(多酚成分)为基础合成的美白成分而被人所知。
4-异丁基间苯二酚具有抑制黑色素生成作用、抗菌作用,特别是为了美白而在化妆品中含有的情况较多,作为美白剂是有用的。
根据本发明的双层化妆品的优选方式,该双层化妆品中,作为药剂包含4-甲氧基水杨酸钾盐、烟酰胺或苯乙基间苯二酚。通过在本发明的双层化妆品中包含这些药剂,能够进一步提高温感效果、使用性,在这方面优选。
根据本发明的双层化妆品的更优选方式,提供如下双层化妆品:(A)药剂为4-甲氧基水杨酸钾盐、烟酰胺、抗坏血酸葡糖甙或4-异丁基间苯二酚,且4-甲氧基水杨酸钾盐、烟酰胺、抗坏血酸葡糖甙或4-异丁基间苯二酚的配合量相对于化妆品的总量为0.25~6质量%。
根据本发明的双层化妆品的更优选的又一方式,提供如下双层化妆品:(A)药剂为苯乙基间苯二酚,且该苯乙基间苯二酚的配合量相对于化妆品的总量为5质量%以下。
<水相>
双层化妆品中含有的水相中,可以配合通常用于化妆品、准药物等的水、水溶性醇、增稠剂等,进而根据期望也可以适宜配合保湿剂、螯合剂、防腐剂、色素等。
本发明的双层化妆品中所含的水没有特别限定,例如可列举出纯化水、离子交换水、自来水等。
本发明的双层化妆品的水相中的水的配合量没有特别限定,优选相对于化妆品的总量为10质量%以下,更优选相对于化妆品的总量为8质量%以下,进一步优选相对于化妆品的总量为7质量%以下。
作为水溶性醇,例如可列举出低级醇、多元醇、多元醇聚合物、二元醇烷基醚类、二甘醇烷基醚类、二元醇醚酯、甘油单烷基醚、糖醇、单糖、低聚糖、多糖及它们的衍生物等,优选为多元醇。
本发明的双层化妆品的水相中的多元醇的配合量没有特别限定,优选相对于化妆品的总量为40~70质量%。
作为低级醇,例如可列举出乙醇、1-丙醇、异丙醇、异丁醇、叔丁醇等。
作为多元醇,例如可列举出二元醇(例如,一缩二丙二醇、1,3-丁二醇、乙二醇、三亚甲基二醇、1,2-丁二醇、四亚甲基二醇、2,3-丁二醇、五亚甲基二醇、2-丁烯-1,4-二醇、己二醇、辛二醇等)、三元醇(例如,甘油、三羟甲基丙烷等)、四元醇(例如,一缩二甘油、1,2,6-己三醇等季戊四醇等)、五元醇(例如,木糖醇、三聚甘油等)、六元醇(例如,山梨糖醇、甘露糖醇等)、多元醇聚合物(例如,二甘醇、一缩二丙二醇-三甘醇、聚丙二醇、四甘醇、一缩二甘油-三聚甘油、四聚甘油、聚甘油等)、二元醇烷基醚类(例如,乙二醇单甲醚、乙二醇单乙醚、乙二醇单丁醚、乙二醇单苯基醚、乙二醇单己醚、乙二醇单2-甲基己醚、乙二醇异戊基醚、乙二醇苄基醚、乙二醇异丙醚、乙二醇二甲醚、乙二醇二乙醚、乙二醇二丁醚等)、二甘醇烷基醚类(例如,二甘醇单甲醚、二甘醇单乙醚、二甘醇单丁醚、二甘醇二甲醚、二甘醇二乙醚、二甘醇丁醚、二甘醇甲基乙醚、三甘醇单甲醚、三甘醇单乙醚、丙二醇单甲醚、丙二醇单乙醚、丙二醇单丁醚、丙二醇异丙醚、一缩二丙二醇甲醚、一缩二丙二醇乙醚、一缩二丙二醇丁醚等)、二元醇醚酯(例如,乙二醇单甲醚乙酸酯、乙二醇单乙醚乙酸酯、乙二醇单丁醚乙酸酯、乙二醇单苯基醚乙酸酯、乙二醇二己二酸酯、乙二醇二琥珀酸酯、二甘醇单乙醚乙酸酯、二甘醇单丁醚乙酸酯、丙二醇单甲醚乙酸酯、丙二醇单乙醚乙酸酯、丙二醇单丙醚乙酸酯、丙二醇单苯基醚乙酸酯等)、甘油单烷基醚(例如,鲛肝醇、鲨油醇、鲨肝醇等)、糖醇(例如,麦芽三糖、甘露糖醇、蔗糖、赤藓醇、葡萄糖、果糖、淀粉分解糖、麦芽糖、淀粉分解糖还原醇等)、glysolid、四氢糠醇、POE-四氢糠醇、POP-丁醚、POP·POE-丁醚三聚氧丙烯甘油醚、POP-甘油醚、POP-甘油醚磷酸、POP·POE-季戊四醇醚、聚甘油等,优选包含选自甘油、一缩二丙二醇、一缩二甘油、山梨糖醇、甲基葡糖醇聚醚-10和1,3-丁二醇中的1种以上。
作为单糖,例如可列举出三碳糖(例如,D-甘油醛、二羟丙酮等)、四碳糖(例如,D-赤藓糖、D-赤藓酮糖、D-苏糖、赤藓醇等)、五碳糖(例如,L-阿拉伯糖、D-木糖、L-来苏糖、D-阿拉伯糖、D-核糖、D-核酮糖、D-木酮糖、L-木酮糖等)、六碳糖(例如,D-葡萄糖、D-塔罗糖、D-阿洛酮糖、D-半乳糖、D-果糖、L-半乳糖、L-甘露糖、D-塔格糖等)、七碳糖(例如,庚醛糖、庚糖等)、八碳糖(例如,辛酮糖等)、脱氧糖(例如,2-脱氧-D-核糖、6-脱氧-L-半乳糖、6-脱氧-L-甘露糖等)、氨基糖(例如,D-葡糖胺、D-半乳糖胺、唾液酸、氨基糖醛酸、胞壁酸等)、糖醛酸(例如,D-葡萄糖醛酸、D-甘露糖醛酸、L-葡萄糖醛酸、D-半乳糖醛酸、L-艾杜糖醛酸等)等。
作为低聚糖,例如可列举出蔗糖、龙胆三糖、伞形花内酯、半乳糖、车前糖、异剪秋罗糖类、α,α-海藻糖、棉子糖、剪秋罗糖类、石耳素(umbilicine)、水苏糖毛蕊花糖类等。
作为多糖,例如可列举出纤维素、榅桲(PYRUS CYDONIA)籽、淀粉、半乳聚糖、硫酸皮肤素、糖原、阿拉伯胶、硫酸乙酰肝素-黄蓍胶、硫酸角质素、软骨素、黄原胶、瓜尔豆胶、葡聚糖、硫酸角质、刺槐豆胶、琥珀酰葡聚糖等。
作为其他多元醇,例如可列举出甲基葡糖苷聚氧乙烯醚(GLUCAM E-10)、甲基葡糖苷聚氧丙烯醚(GLUCAM P-10)等。
作为天然的水溶性高分子,例如可列举出植物系高分子(例如,阿拉伯胶、黄耆胶、半乳聚糖、瓜尔豆胶、角豆树胶、卡拉牙胶、角叉菜胶、果胶、琼脂、榅桲(PYRUS CYDONIA)籽(榅桲)、藻酸钠(褐藻提取物)、淀粉(大米、玉米、马铃薯、小麦)、甘草酸)、微生物系高分子(例如,黄原胶、葡聚糖、琥珀酰葡聚糖、出芽短梗酶多糖等)、动物系高分子(例如,骨胶原、酪朊、白蛋白、明胶等)等。
作为半合成的水溶性高分子,例如可列举出淀粉系高分子(例如,羧甲基淀粉、甲基羟丙基淀粉等)、纤维素系高分子(甲基纤维素、乙基纤维素、甲基羟丙基纤维素、羟乙基纤维素、纤维素硫酸钠、羟丙基纤维素、羧甲基纤维素、羧甲基纤维素钠、微晶纤维素、纤维素粉等)、藻酸系高分子(例如,藻酸钠、丙二醇藻酸酯等)等。
作为合成的水溶性高分子,例如可列举出乙烯系高分子(例如,聚乙烯醇、聚乙烯甲基醚、聚乙烯吡咯烷酮、羧基乙烯基聚合物等)、聚氧乙烯系高分子(例如,聚乙二醇20000、40000、60000等)、丙烯酸系高分子(例如,聚丙烯酸钠、聚丙烯酸乙酯、聚丙烯酰胺等)、聚乙烯亚胺、阳离子聚合物等。
作为保湿剂,例如可列举出硫酸软骨素、透明质酸、硫酸粘多糖、卡洛宁酸、去端肽胶原、12-羟基硬脂酸胆甾醇酯、乳酸钠、胆汁酸盐、DL-吡咯烷酮羧酸盐、短链可溶性骨胶原、一缩二甘油(EO)PO加成物、刺梨(ROSA ROXBURGHII)果提取物、欧蓍草(ACHILLEAMILLEFOLIUM)提取物、草木犀(MELILOTUS OFFICINALIS)提取物等。
作为掩蔽剂,例如可列举出1-羟基乙烷-1,1-二膦酸、1-羟基乙烷-1,1-二膦酸四钠盐、依地酸二钠、依地酸三钠、依地酸四钠、柠檬酸钠、多磷酸钠、偏磷酸钠、葡糖酸、磷酸、柠檬酸、抗坏血酸、琥珀酸、依地酸、HEDTA三钠等。
作为氨基酸,例如可列举出中性氨基酸(例如,苏氨酸、半胱氨酸等)、碱性氨基酸(例如,羟基赖氨酸等)等。另外,作为氨基酸衍生物,例如可列举出酰基肌氨酸钠(月桂酰肌氨酸钠)、酰基谷氨酸盐、酰基β-丙氨酸钠、谷胱甘肽等。
作为pH调节剂,例如可列举出乳酸-乳酸钠、柠檬酸-柠檬酸钠、琥珀酸-琥珀酸钠等缓冲剂等。
作为增稠剂,例如可列举出黄原胶、阿拉伯胶、角叉菜胶、卡拉牙胶、黄耆胶、角豆树胶、榅桲(PYRUS CYDONIA)籽(榅桲)、酪朊、糊精、明胶、果胶酸钠、藻酸钠、甲基纤维素、乙基纤维素、CMC、羟乙基纤维素、羟丙基纤维素、PVA、PVM、PVP、聚丙烯酸钠、羧基乙烯基聚合物、刺槐豆胶、瓜尔豆胶、酸豆(TAMARINDUS INDICA)籽胶、二烷基二甲基铵纤维素硫酸酯盐、硅酸铝镁盐、澎润土、水辉石、硅酸AlMg(VEEGUM)、合成锂皂石、无水硅酸等。
<油相>
作为本发明的双层化妆品中含有的油相中的油相成分,没有特别限定,可列举出通常用于化妆品、准药物等的烃油、高级脂肪酸、高级醇、合成酯油、硅油、液体油脂、固体油脂、蜡、香料等。
作为烃油,例如可列举出异十二烷、异十六烷、异链烷烃、液体石蜡、地蜡、角鲨烷、姥鲛烷、石蜡、纯地蜡、角鲨烯、矿脂、微晶蜡等。
作为高级脂肪酸,例如可列举出月桂酸、肉豆蔻酸、棕榈酸、硬脂酸、二十二烷酸、油酸、十一烯酸、妥尔油酸、异硬脂酸、亚油酸、亚麻酸、二十碳五烯酸(EPA)、二十二碳六烯酸(DHA)等。
作为高级醇,例如可列举出直链醇(例如,月桂醇、鲸蜡醇、硬脂醇、二十二烷醇、肉豆蔻醇、油醇、鲸蜡硬脂醇等)、支链醇(例如,单硬脂基甘油醚(鲨肝醇)-2-癸基十四烷醇、羊毛脂醇、胆甾醇、植物甾醇、己基十二烷醇、异硬脂醇、辛基十二烷醇等)等。
作为合成酯油,例如可列举出辛酸辛酯、壬酸壬酯、辛酸十六烷基酯、肉豆蔻酸异丙酯、肉豆蔻酸辛基十二烷基酯、棕榈酸异丙酯、硬脂酸丁酯、月桂酸己酯、肉豆蔻酸肉豆蔻酯、油酸癸酯、己基癸醇辛酸二甲酯、鲸蜡醇乳酸酯、肉豆蔻醇乳酸酯、乙酰化羊毛脂、异鲸蜡醇硬脂酸酯、异鲸蜡醇异硬脂酸酯、胆甾醇12-羟基硬脂酸酯、乙二醇二(2-乙基己酸)酯、二季戊四醇脂肪酸酯、N-烷基二醇单异硬脂酸酯、新戊二醇二癸酸酯、三丙二醇新戊酸酯、二异硬脂醇苹果酸酯、二-2-庚基十一烷酸甘油酯、甘油二异硬脂酸酯、三羟甲基丙烷三(2-乙基己酸)酯、三羟甲基丙烷三异硬脂酸酯、季戊四醇四(2-乙基己酸)酯、2-乙基己酸三甘油酯、三辛酸甘油酯、甘油三异棕榈酸酯、三羟甲基丙烷三异硬脂酸酯、鲸蜡醇2-乙基己酸酯、棕榈酸2-乙基己酯、甘油三肉豆蔻酸酯、甘油三(2-庚基十一烷酸)酯、蓖麻油脂肪酸甲酯、油醇油酸酯、乙酰甘油酯、二(庚基十一烷醇)棕榈酸酯、己二酸二异丁酯、N-月桂酰基-L-谷氨酸-2-辛基十二烷基酯、二(2-庚基十一烷醇)己二酸酯、月桂酸乙酯、癸二酸二(2-乙基己基)酯、肉豆蔻酸2-己基癸酯、棕榈酸2-己基癸酯、己二酸2-己基癸酯、癸二酸二异丙酯、琥珀酸2-乙基己酯、柠檬酸三乙酯等,这些之中,优选为肉豆蔻酸异丙酯。
作为硅油,例如可列举出链状聚硅氧烷(例如,二甲基聚硅氧烷(聚二甲基硅氧烷)、甲基苯基聚硅氧烷、二苯基聚硅氧烷等)、环状聚硅氧烷(例如,八甲基环四硅氧烷、十甲基环五硅氧烷、十二甲基环己硅氧烷等)、形成三维网眼结构的有机硅树脂、硅橡胶、各种改性聚硅氧烷(氨基改性聚硅氧烷、聚醚改性聚硅氧烷、烷基改性聚硅氧烷、氟改性聚硅氧烷等)、丙烯酸有机硅类等,这些之中优选为二甲基聚硅氧烷。
作为液体油脂,例如可列举出鳄梨油、山茶油、海龟油、澳洲坚果籽油、玉米油、貂油、橄榄油、菜籽油、蛋黄油、芝麻油、桃仁油、小麦胚芽油、山茶花油、蓖麻油、亚麻籽油、红花油、棉籽油、紫苏油、大豆油、花生油、茶籽油、榧子油、米糠油、泡桐油、日本桐油、霍霍巴油、胚芽油、三聚甘油等,这些之中优选为霍霍巴油。
作为固体油脂,例如可列举出可可脂、椰子油、马脂、氢化椰子油、棕榈油、牛脂、羊脂、氢化牛脂、棕榈仁油、猪脂、牛骨脂、日本蜡仁油、氢化油、牛蹄油、野漆果蜡、氢化蓖麻油等。
作为蜡类,例如可列举出蜜蜡、小烛树蜡、棉蜡、巴西棕榈蜡、杨梅蜡、虫蜡、鲸蜡、褐煤蜡、糠蜡、羊毛脂、木棉蜡、乙酰化羊毛脂、羊毛脂油、甘蔗蜡、羊毛脂酸异丙酯、月桂酸己酯、氢化羊毛脂、霍霍巴蜡、硬质羊毛脂、虫胶蜡、羊毛脂醇POE醚、羊毛脂醇POE乙酸酯、胆甾醇POE醚、聚乙二醇羊毛脂酸酯、氢化羊毛脂醇POE醚等。
作为香料,可列举出由动物或植物得到的天然香料以及通过化学合成手段制造的合成香料及作为这些的混合物的调合香料,没有特别限定。通过配合香料,能够得到香味的持续性优异的化妆品。
作为香料,具体而言,可列举出acetivenol、茴香醛、茴香脑、乙酸戊酯、水杨酸戊酯、格蓬酯、己酸烯丙酯、醛C6~20、黄葵内酯、麝子内酯、降龙涎醚、紫罗兰酮、龙涎酮、丁子香酚、橙花素、佳乐麝香、西瓜酮、香豆素、香叶醇、乙酸香叶酯、檀香仲醇、檀香伯醇、sandela、仙客来醛、顺式-3-己烯基乙酸酯、顺式-3-己烯醇、柠檬醛、香茅醇乙酸酯、香茅醇、桉树脑、二氢月桂烯醇、茉莉内酯、肉桂醇、肉桂醛、乙酸苏合香酯、乙酸柏木酯、雪松醇、突厥酮、突厥烯酮、癸内酯、乙酸松油酯、萜品醇、吐纳麝香、女贞醛、橙花醇、白檀醇、香草醛、羟基香茅醛、乙酸苯乙酯、苯乙醇、水杨酸己酯、乙酰化岩兰油、二氢茉莉酮酸甲酯、胡椒醛、新洋茉莉醛、vertofix、乙酸苄酯、水杨酸苄酯、苯甲酸苄酯、环十五内酯(pentalide)、乙酸冰片酯、myol、酮麝香、邻氨基苯甲酸甲酯、二氢茉莉酮酸甲酯、乙位萘甲醚、limeoxide、乙酸芳樟酯、芳樟醇、柠檬烯、新铃兰醛、铃兰醛、玫瑰氧化物、玫瑰醇、白芷油、大茴香油、艾蒿油、罗勒油、月桂油、佛手油、白菖蒲油、樟脑油、卡南迦油、小豆蔻油、肉桂油(cassia oil)、柏木油、洋芹油、甘菊油、肉桂油(cinnamon oil)、丁香油、芫荽油、枯茗油、莳萝油、榄香油、龙蒿油、桉树油、茴香油、葫芦巴油、格蓬油、天竺葵油、姜油、葡萄柚油、愈创木油、桧木油、丝柏油、杜松子油、杂薰衣草油、薰衣草油、柠檬油、梨莓油、桔油、giraffeoil、银白金合欢油、椒样薄荷油、留兰香油、mill oil、桃金娘油、肉豆蔻油、橡苔树脂油、乳香精油、防风根油、甜橙油、欧芹油、广藿香油、黑胡椒油、荏油、橙叶油、橙花油、酸橙油、多香果油、玉桂油、松木油、玫瑰油、迷迭香油、香鼠尾草油、鼠尾草油、檀香木油、苏合香油、万寿菊油、麝香草油、晚香玉油、缬草油、香根油、香堇菜油、冬绿油、艾蒿油、伊朗油、香橙果油、合欢金净油、金雀花净油、风信子净油、蜡菊净油(immortelle absolute)、茉莉净油、长寿花净油、水仙净油、玫瑰净油、香堇菜净油、benzoin等。
<表面活性剂>
本发明的双层化妆品通过配合4-甲氧基水杨酸钾盐等药剂,能够尽可能不使用通常的双层化妆品中为了分离性、表面稳定性而配合的表面活性剂来确保制剂稳定性。因此,本发明的双层化妆品中配合的表面活性剂的配合量优选相对于化妆品的总量低于0.01质量%。
本说明书中,表面活性剂是指:离子性表面活性剂(阴离子性表面活性剂、阳离子性表面活性剂和两性表面活性剂)以及非离子性表面活性剂,进而除了这4种表面活性剂以外,高分子表面活性剂、有机硅系表面活性剂和天然表面活性剂等也包括在本说明书的表面活性剂的范围内。
<其他成分>
本发明的双层化妆品中,在不有损本发明的效果的范围内,可以适宜配合通常化妆品、准药物等中使用的其他成分、例如紫外线吸收剂、粉末、有机胺、高分子乳液、维生素类、抗氧化剂等。
作为水溶性紫外线吸收剂,例如可列举出2,4-二羟基二苯甲酮、2,2’-二羟基-4-甲氧基二苯甲酮、2,2’-二羟基-4,4’-二甲氧基二苯甲酮、2,2’,4,4’-四羟基二苯甲酮、2-羟基-4-甲氧基二苯甲酮、2-羟基-4-甲氧基-4’-甲基二苯甲酮、2-羟基-4-甲氧基二苯甲酮-5-磺酸盐、4-苯基二苯甲酮、2-乙基己基-4’-苯基-二苯甲酮-2-羧酸盐、2-羟基-4-正辛氧基二苯甲酮、4-羟基-3-羧基二苯甲酮等二苯甲酮系紫外线吸收剂、苯基苯并咪唑-5-磺酸及其盐、亚苯基-双-苯并咪唑-四磺酸及其盐等苯并咪唑系紫外线吸收剂、3-(4’-甲基亚苄基)-d,l-樟脑、3-亚苄基-d,l-樟脑、尿刊酸、尿刊酸乙酯等。
作为油溶性紫外线吸收剂,例如可列举出对氨基苯甲酸(PABA)、单甘油PABA酯、N,N-二丙氧基PABA乙酯、N,N-二乙氧基PABA乙酯、N,N-二甲基PABA乙酯、N,N-二甲基PABA丁酯等苯甲酸系紫外线吸收剂;高孟基-N-乙酰邻氨基苯甲酸酯等邻氨基苯甲酸系紫外线吸收剂;水杨酸戊酯、水杨酸甲酯、水杨酸高孟酯、水杨酸辛酯、水杨酸苯酯、水杨酸苄酯、水杨酸对异丙醇苯酯等水杨酸系紫外线吸收剂;肉桂酸辛酯、乙基-4-异丙基肉桂酸酯、甲基-2,5-二异丙基肉桂酸酯、乙基-2,4-二异丙基肉桂酸酯、甲基-2,4-二异丙基肉桂酸酯、对甲氧基肉桂酸丙酯、对甲氧基肉桂酸异丙酯、对甲氧基肉桂酸异戊酯、对甲氧基肉桂酸辛酯、2-乙基己基-对甲氧基肉桂酸酯、2-乙氧基乙基-对甲氧基肉桂酸酯、对甲氧基肉桂酸环己酯、α-氰基-β-苯基肉桂酸乙酯、2-乙基己基-α-氰基-β-苯基肉桂酸酯、甘油单-2-乙基己酰基-二对甲氧基肉桂酸酯、3,4,5-三甲氧基肉桂酸3-甲基-4-[甲基双(三甲基甲硅烷氧基)甲硅烷基]丁酯等肉桂酸系紫外线吸收剂;2-苯基-5-甲基苯并噁唑、2,2’-羟基-5-甲基苯基苯并三唑、2-(2’-羟基-5’-叔辛基苯基)苯并三唑、2-(2’-羟基-5’-甲基苯基苯并三唑、二苯扎嗪、二苯胺基甲烷、4-甲氧基-4’-叔丁基二苯甲酰甲烷、5-(3,3-二甲基-2-降冰片烯)-3-戊-2-酮、奥克立林等。
作为粉末成分,例如可列举出无机粉末(例如,滑石粉、高岭土、云母、绢云母(sericite)、白云母、金云母、合成云母、红云母、黑云母、蛭石、碳酸镁、碳酸钙、硅酸铝、硅酸钡、硅酸钙、硅酸镁、硅酸锶、钨酸金属盐、镁、二氧化硅、沸石、硫酸钡、煅烧硫酸钙(exsiccated gypsum)、磷酸钙、氟磷灰石、羟基磷灰石、陶瓷粉、金属皂(例如,肉豆蔻酸锌、棕榈酸钙、硬脂酸铝)、氮化硼等)、有机粉末(例如,聚酰胺树脂粉末(尼龙粉末)、聚乙烯粉末、聚甲基丙烯酸甲酯粉末、聚苯乙烯粉末、苯乙烯和丙烯酸共聚物树脂粉末、苯并胍胺树脂粉末、聚四氟乙烯粉末、纤维素粉末等)、无机白色颜料(例如,二氧化钛、氧化锌等)、无机红色系颜料(例如,氧化铁(铁丹)、钛酸铁等)、无机褐色系颜料(例如,γ-氧化铁等)、无机黄色系颜料(例如,氧化铁黄、黄土等)、无机黑色系颜料(例如,氧化铁黑、低价氧化钛等)、无机紫色系颜料(例如,芒果紫、钴紫等)、无机绿色系颜料(例如,氧化铬、氢氧化铬、钛酸钴等)、无机蓝色系颜料(例如,群青、普鲁士蓝等)、珠光颜料(例如,氧化钛钴云母、氧化钛钴氧氯化铋、氧化钛涂层滑石、着色氧化钛涂层云母、氧氯铋、鱼鳞箔等)、金属粉末颜料(例如,铝粉、铜粉等)、锆、钡或铝色淀等有机颜料(例如,红色201号、红色202号、红色204号、红色205号、红色220号、红色226号、红色228号、红色405号、橙色203号、橙色204号、黄色205号、黄色401号、及蓝色404号等の有机颜料、红色3号、红色104号、红色106号、红色227号、红色230号、红色401号、红色505号、橙色205号、黄色4号、黄色5号、黄色202号、黄色203号、绿色3号及蓝色1号等)、天然色素(例如,叶绿素、β-胡萝卜素等)等。
作为有机胺,例如可列举出单乙醇胺、二乙醇胺、三乙醇胺、吗啉、四(2-羟丙基)乙二胺、三异丙醇胺、2-氨基-2-甲基-1,3-丙二醇、2-氨基-2-甲基-1-丙醇等。
作为高分子乳液,例如可列举出丙烯酸树脂乳液、聚丙烯酸乙酯乳液、丙烯酸树脂液、聚丙烯酸烷基酯乳液、聚醋酸乙烯酯树脂乳液、天然橡胶胶乳等。
作为维生素类,例如可列举出维生素A、B1、B2、B6、C、E及其衍生物、泛酸及其衍生物、生物素等。
作为其他可配合成分,例如可列举出防腐剂(对羟基苯甲酸甲酯、对羟基苯甲酸乙酯、对羟基苯甲酸丁酯、苯氧乙醇等)、消炎剂(例如,甘草酸衍生物、甘草亭酸衍生物、水杨酸衍生物、桧木醇、氧化锌、尿囊素等)、美白剂(例如,胎盘提取物、草莓虎耳草提取物、熊果苷等)、各种提取物(例如,黄檗树皮、日本黄连、紫草根、芍药、日本獐牙菜、桦木、药鼠尾草、枇杷、人参、芦荟、欧锦葵、香根鸢尾、葡萄、薏苡、丝瓜、白花百合、番红花、日本川芎、姜根、贯叶连翘、红芒柄花根、大蒜、辣椒果、温州蜜桔果皮、海藻等)、活化剂(例如,蜂王浆、感光素、胆甾醇衍生物等)、血液循环促进剂(例如,壬酸香草酰胺、烟酸苄酯、烟酸β-丁氧基乙酯、辣椒素、姜油酮、姜黄素、鱼石脂、丹宁酸、α-莰醇、生育酚烟酸酯、肌醇烟酸酯、环扁桃酯、桂利嗪、妥拉唑林、乙酰胆碱、维拉帕米、千金藤素、γ-谷维素等)、抗皮脂溢剂(例如,硫、二甲噻蒽等)、抗炎症剂(例如,凝血酸、硫代牛磺酸、亚牛磺酸等)等。
作为抗氧化剂,例如可列举出生育酚类、二丁基羟基甲苯、丁羟基茴香醚、没食子酸酯类等。
作为酸化防止助剤,例如可列举出磷酸、柠檬酸、抗坏血酸、马来酸、丙二酸、琥珀酸、富马酸、脑磷脂、hexameta phosphate、植酸、乙二胺四乙酸等。
根据本发明的优选的方式,可提供双层温感化妆品(优选为双层温感美白化妆水),其含有:(A)选自由4-甲氧基水杨酸钾盐、烟酰胺、抗坏血酸葡糖甙、苯乙基间苯二酚和4-异丁基间苯二酚组成的组中的1种以上的药剂;(B)水相;和(C)油相。作为具有赋予温感效果的发热性物质,可列举出上述多元醇、沸石、金属盐或金属氧化物等。这些都是吸湿性的,在与皮肤上的水分接触时会发热,从而能够给皮肤带来温感。
实施例
基于下述例子对本发明进行具体说明,但本发明不限定于这些例子。含量在没有特别记载的情况下表示质量%。
试验例1
关于下述的实施例1~11以及比较例1~6的双层化妆品(参照表1以及2),针对“双层稳定性”、“温感效果”、“分离性”以及“使用性(无粘腻感)”进行评价。各评价的评价方法如下述那样进行。另外,将各评价结果示于下述表3及4。
(1)双层稳定性
关于下述的实施例1~11以及比较例1~6的双层化妆品,在水相中能够均匀地溶解药剂等,添加油相,然后确认是否具有均匀的双层的外观(双层稳定性),基于下述基准进行评价。
<评价基准>
A:能够调制,未见异常,稳定
B:调制时观察到异常,不稳定
(2)温感效果
关于下述的实施例1~11以及比较例1~6的双层化妆品,由专业小组成员10名实施实际使用试验。具体而言,将基于下述表1以及2调制的双层化妆品涂布到各小组成员的面部,基于下述基准对温感进行评价。
<评价基准>
A:专业小组成员8名以上确认到有温感效果
B:专业小组成员5名以上且低于8名确认到有温感效果
C:专业小组成员3名以上且低于5名确认到有温感效果
D:专业小组成员低于3名确认到有温感效果
(3)分离性
调制下述的实施例1~11以及比较例1~6的双层化妆品并搅拌后,测定化妆品的分离相表示出一成左右为止的均匀一层的时间。
<评价基准>
A:20秒以上且低于30分钟发生分离
B:10秒以上且低于20秒发生分离
C:低于10秒发生分离或30分钟以上未分离
(4)使用性(无粘腻感)
将下述的实施例1~11以及比较例1~6的双层化妆品涂布于肌肤,针对粘腻的有无,基于下述基准进行评价。
<评价基准>
A:无粘腻、良好的使用性
B:粘腻少的使用性
C:粘腻强、无良好的使用性
[表1]
[表2]
[表3]
[表4]
由上述表3及4的结果可知,本发明的范围内的双层化妆品(实施例1~11)与不在本发明的范围内的双层化妆品(比较例1~6)相比,具有优异的双层稳定性、分离性良好且使用性良好。
由上述表3及4的结果,双层化妆品的水相中的水的配合量相对于化妆品的总量为10质量%以下的情况下,包含在本发明的范围内的双层化妆品(实施例1~4及6~11)在温感效果方面也良好。
Claims (10)
1.一种双层化妆品,其含有:
(A)选自由4-甲氧基水杨酸钾盐、烟酰胺、抗坏血酸葡糖甙、苯乙基间苯二酚和4-异丁基间苯二酚组成的组中的1种以上的药剂;
(B)水相;和
(C)油相。
2.根据权利要求1所述的化妆品,其中,所述(B)水相中的水的配合量相对于化妆品的总量为10质量%以下。
3.根据权利要求1或2所述的化妆品,其中,所述(B)水相中包含多元醇。
4.根据权利要求3所述的化妆品,其中,所述多元醇包含选自甘油、一缩二丙二醇、一缩二甘油、山梨糖醇、甲基葡糖醇聚醚-10和1,3-丁二醇中的1种以上。
5.根据权利要求3或4所述的化妆品,其中,所述多元醇的配合量相对于化妆品的总量为40~70质量%。
6.根据权利要求1~5中任一项所述的化妆品,其中,化妆品为温感化妆品。
7.根据权利要求1~6中任一项所述的化妆品,其中,所述(A)药剂为4-甲氧基水杨酸钾盐、烟酰胺或苯乙基间苯二酚。
8.根据权利要求1~6中任一项所述的化妆品,其中,
所述(A)药剂为4-甲氧基水杨酸钾盐、烟酰胺、抗坏血酸葡糖甙或4-异丁基间苯二酚,且
4-甲氧基水杨酸钾盐、烟酰胺、抗坏血酸葡糖甙或4-异丁基间苯二酚的配合量相对于化妆品的总量为0.25~6质量%。
9.根据权利要求1~6中任一项所述的化妆品,其中,
所述(A)药剂为苯乙基间苯二酚,且
所述苯乙基间苯二酚的配合量相对于化妆品的总量为5质量%以下。
10.根据权利要求1~9中任一项所述的化妆品,其中,
表面活性剂的配合量相对于化妆品的总量低于0.01质量%。
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PCT/JP2022/010207 WO2022196480A1 (ja) | 2021-03-19 | 2022-03-09 | 2層化粧料 |
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