WO2013094322A1 - 対象成分を操作するためのチップデバイス及びそれを用いた方法 - Google Patents

対象成分を操作するためのチップデバイス及びそれを用いた方法 Download PDF

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Publication number
WO2013094322A1
WO2013094322A1 PCT/JP2012/078587 JP2012078587W WO2013094322A1 WO 2013094322 A1 WO2013094322 A1 WO 2013094322A1 JP 2012078587 W JP2012078587 W JP 2012078587W WO 2013094322 A1 WO2013094322 A1 WO 2013094322A1
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Prior art keywords
groove
aqueous liquid
liquid phase
nucleic acid
magnetic particles
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Ceased
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PCT/JP2012/078587
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English (en)
French (fr)
Japanese (ja)
Inventor
功 片所
鉄雄 大橋
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Shimadzu Corp
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Shimadzu Corp
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Priority to US14/365,104 priority Critical patent/US9714445B2/en
Priority to CN201280062684.7A priority patent/CN103998940B/zh
Publication of WO2013094322A1 publication Critical patent/WO2013094322A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/02—Food
    • G01N33/04—Dairy products
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02K—DYNAMO-ELECTRIC MACHINES
    • H02K44/00—Machines in which the dynamo-electric interaction between a plasma or flow of conductive liquid or of fluid-borne conductive or magnetic particles and a coil system or magnetic field converts energy of mass flow into electrical energy or vice versa
    • H02K44/02—Electrodynamic pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture

Definitions

  • the magnetic particles in the groove give a shearing force to the gel along the conveying surface by moving the magnet from the outside, and the gel in the forward direction of the magnetic particles is sol and fluidized, so that the magnetic particles proceed as they are. be able to.
  • the sol released from the shearing force after the magnetic particles have passed through returns quickly to the gel state, so that the gel does not form through holes due to the passage of the magnetic particles.
  • the nucleic acid amplification reaction according to the present invention is not particularly limited.
  • the PCR method (US Pat. Nos. 4,683,195, 4,683,202, 4,800,159, and 4,965,188), the LCR method (US Pat. No. 5,494,810). No. 4), Q ⁇ method (US Pat. No. 4,786,600), NASBA method (US Pat. No. 5,409,818), LAMP method (US Pat. No. 3,313,358), SDA method (US Pat. No. 5,455,166), RCA method ( U.S. Pat. No. 5,354,688), ICAN method (Japanese Patent No. 3433929), TAS method (Japanese Patent No. 2443586), and the like can be used.
  • RT reaction can also be performed prior to the above reaction.
  • the composition of the reaction solution necessary for these nucleic acid amplification reactions and the reaction temperature can be appropriately selected by those skilled in the art.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Food Science & Technology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Fluid Mechanics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Power Engineering (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
PCT/JP2012/078587 2011-12-22 2012-11-05 対象成分を操作するためのチップデバイス及びそれを用いた方法 Ceased WO2013094322A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US14/365,104 US9714445B2 (en) 2011-12-22 2012-11-05 Chip device for manipulating object component, and method using the same
CN201280062684.7A CN103998940B (zh) 2011-12-22 2012-11-05 芯片装置、操作芯片的制作方法及操作对象成分的方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011282185A JP5807542B2 (ja) 2011-12-22 2011-12-22 対象成分を操作するためのチップデバイス及びそれを用いた方法
JP2011-282185 2011-12-22

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Publication Number Publication Date
WO2013094322A1 true WO2013094322A1 (ja) 2013-06-27

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US (1) US9714445B2 (enExample)
JP (1) JP5807542B2 (enExample)
CN (1) CN103998940B (enExample)
WO (1) WO2013094322A1 (enExample)

Cited By (2)

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US20210046237A1 (en) * 2015-09-14 2021-02-18 Medisieve Ltd Magnetic filter apparatus and method
CN117264750A (zh) * 2023-11-23 2023-12-22 中国科学院空天信息创新研究院 检测卡盒及其使用方法

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JP6353155B2 (ja) * 2014-12-02 2018-07-04 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 微小流体工学システムにおける磁性粒子の分散および蓄積
JP6332012B2 (ja) * 2014-12-22 2018-05-30 株式会社島津製作所 磁性体粒子操作用装置
US10941394B2 (en) * 2015-01-15 2021-03-09 Shimadzu Corporation Device for manipulating magnetic particles and method for manipulating magnetic particles
WO2016121102A1 (ja) * 2015-01-30 2016-08-04 株式会社島津製作所 磁性体粒子操作用デバイスおよび磁性体粒子の操作方法
CN107532990B (zh) 2015-05-12 2021-11-12 芯片生物技术株式会社 单一粒子解析方法及用于该解析的系统
CN118681610A (zh) * 2015-07-24 2024-09-24 新型微装置股份有限公司 微流体样品处理设备和制备生物样品的方法
ES2599056B2 (es) * 2015-07-31 2017-07-07 Pablo ALBERTOS SÁNCHEZ Dispositivo para ensayar una muestra de células
KR101850307B1 (ko) 2016-03-03 2018-04-20 한국과학기술연구원 채널 결합형 스캐폴드의 제조장치 및 제조방법
CN107541462B (zh) * 2017-09-13 2021-02-23 北京理工大学 一种用于核酸纯化，扩增及基因检测的系统及应用方法
WO2019130558A1 (ja) * 2017-12-28 2019-07-04 株式会社ニコン 流体デバイスおよび流路供給システム
CN108801306B (zh) * 2018-06-26 2020-01-24 京东方科技集团股份有限公司 光纤传感器及其制作方法、运动感测装置
TWI688320B (zh) * 2018-10-26 2020-03-11 友達光電股份有限公司 轉置方法及轉置裝置
WO2021047533A1 (en) * 2019-09-10 2021-03-18 Bgi Shenzhen Co., Ltd. Operation of magnetic beads on microfluidics substrates
CN115747037A (zh) * 2023-01-09 2023-03-07 深圳市科瑞达生物技术有限公司 核酸分析卡及其使用方法
CN118017795B (zh) * 2024-04-08 2024-06-25 浙江大学 感应式电磁泵

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210046237A1 (en) * 2015-09-14 2021-02-18 Medisieve Ltd Magnetic filter apparatus and method
US11986585B2 (en) * 2015-09-14 2024-05-21 Medisieve Ltd Magnetic filter apparatus and method
CN117264750A (zh) * 2023-11-23 2023-12-22 中国科学院空天信息创新研究院 检测卡盒及其使用方法
CN117264750B (zh) * 2023-11-23 2024-01-30 中国科学院空天信息创新研究院 检测卡盒及其使用方法

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JP5807542B2 (ja) 2015-11-10
US9714445B2 (en) 2017-07-25
CN103998940B (zh) 2016-07-27
CN103998940A (zh) 2014-08-20
JP2013130548A (ja) 2013-07-04
US20140370511A1 (en) 2014-12-18

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