WO2013061590A1 - Sonde optique et procédé de fabrication de celle-ci - Google Patents

Sonde optique et procédé de fabrication de celle-ci Download PDF

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Publication number
WO2013061590A1
WO2013061590A1 PCT/JP2012/006835 JP2012006835W WO2013061590A1 WO 2013061590 A1 WO2013061590 A1 WO 2013061590A1 JP 2012006835 W JP2012006835 W JP 2012006835W WO 2013061590 A1 WO2013061590 A1 WO 2013061590A1
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WIPO (PCT)
Prior art keywords
optical
fiber
tip
filter
optical fiber
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PCT/JP2012/006835
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English (en)
Japanese (ja)
Inventor
夏野　靖幸
祥一 田尾
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コニカミノルタアドバンストレイヤー株式会社
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Publication of WO2013061590A1 publication Critical patent/WO2013061590A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00165—Optical arrangements with light-conductive means, e.g. fibre optics
    • A61B1/0017—Details of single optical fibres, e.g. material or cladding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/043—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6484—Optical fibres

Definitions

  • the present invention relates to an optical probe, more specifically, a medical optical probe used for measuring optical characteristics inside a body cavity, and a method for manufacturing the same.
  • a long optical probe having flexibility (hereinafter simply referred to as “probe”) is inserted into a body cavity (in the case of digestive system, stomach, esophagus, etc.) by inserting it into a channel of an endoscope, for example. It is conventionally known to measure the optical characteristics of a living tissue inside a body cavity by using a probe using a probe (see, for example, Patent Documents 1, 2, and 3).
  • a near infrared spectroscopic method As a spectroscopic method for measurement using a probe, a near infrared spectroscopic method, a fluorescence method, a Raman spectroscopic method, and the like are known.
  • near-infrared light is irradiated to a site to be observed in the body cavity, for example, a lesion, and the spectrum of reflected light from the lesion is analyzed, so that the living body of the lesion is analyzed. Analyze tissue components.
  • a common point between fluorescence and Raman spectroscopy is that a biological tissue is irradiated with a relatively narrow-band excitation light, and as a result, fluorescence or Raman scattered light (measurement light) that appears in a wavelength region different from the excitation light is included.
  • the reflected light is generated from the living tissue, and the reflected light is received and detected by the spectroscope, thereby analyzing the state of the living tissue of the lesioned part.
  • an optical filter that passes only the wavelength of irradiation light is attached to the tip on the irradiation side, and the tip on the light receiving side. Is equipped with an optical filter for cutting the wavelength of the irradiation light.
  • an optical filter in a probe that uses both an optical fiber for irradiating excitation light (irradiation optical fiber) and an optical fiber for receiving measurement light (light receiving optical fiber).
  • an optical filter that passes only the wavelength of the excitation light is installed near the exit end face of the irradiation optical fiber, and an optical filter that cuts the wavelength of the excitation light is installed near the incident end face of the light receiving optical fiber (for example, patent Reference 3).
  • the probe described in Patent Document 2 uses a quartz fiber having an outer layer with a metal jacket having a thickness of about 10 to 20 ⁇ m as an irradiation optical fiber, and leaks light from the outer peripheral surface thereof. It is preventing.
  • each optical filter it is also required to ensure the light shielding property of the outer peripheral portion of each optical filter so that light does not leak from the outer peripheral portion of the irradiation side optical filter to the outer peripheral portion of the light receiving side optical filter. This is because the above crosstalk can occur between filters or between a filter and an optical fiber.
  • the optical fiber with the metal jacket as described above is a probe due to the fact that there are few suppliers, it is expensive, and the core diameter / cladding diameter / jacket diameter is limited in what is usually available. There is a problem that the optical design is limited.
  • the adhesive is usually a plastic that generates fluorescence and Raman scattered light with respect to the irradiation light, there is a problem that it is not suitable for use in an optical path.
  • An object of the present invention is to provide an optical probe capable of ensuring light-shielding performance without using a special optical fiber such as an optical fiber with a metal jacket in a probe including an optical fiber and a filter, and a method for manufacturing the same. That is.
  • the light shielding property here means, for example, the light shielding property between the irradiation optical fiber and the light receiving optical fiber, between the filters, and between the fiber and the filter.
  • Another object of the present invention is to provide an optical probe capable of improving the accuracy of internal measurement of a body cavity by Raman spectroscopy and a method for manufacturing the same, in which the tightness of the optical path is ensured.
  • the optical probe according to the present invention is: A first optical fiber having a first fiber tip that emits irradiation light to the site to be observed in the body cavity; A second optical fiber having a second fiber tip that receives fluorescence or Raman scattered light from the site to be observed; A first optical filter disposed at the tip of the first fiber; A second optical filter disposed at the tip of the second fiber, At least one of the first optical fiber, the second optical fiber, the first optical filter, and the second optical filter is subjected to a process for forming a metal film.
  • the method for producing an optical probe according to the present invention includes: A first optical fiber having a first fiber tip that emits irradiation light to the site to be observed in the body cavity; A second optical fiber having a second fiber tip that receives fluorescence or Raman scattered light from the site to be observed; A first optical filter disposed at the tip of the first fiber; A second optical filter disposed at the tip of the second fiber, and a method of manufacturing an optical probe comprising: At least one of the first optical fiber, the second optical fiber, the first optical filter, and the second optical filter is subjected to a process of forming a metal film.
  • a probe having an optical fiber and a filter in a probe having an optical fiber and a filter, light shielding properties can be ensured without using a special optical fiber such as an optical fiber having a metal jacket.
  • the accuracy of measurement inside the body cavity by Raman spectroscopy can be improved.
  • FIG. 1 Diagram showing a configuration example of a diagnostic system
  • Sectional drawing which shows the structure of the optical fiber for irradiation in the probe which concerns on Embodiment 1, and the optical fiber for light reception except a front-end
  • FIG. Sectional drawing which shows the 1st modification about the principal part structure of the probe which concerns on Embodiment 1.
  • FIG. 1 Sectional drawing which shows the 3rd modification about the principal part structure of the probe which concerns on Embodiment 1.
  • FIG. Sectional drawing which shows the principal part structure of the probe which concerns on Embodiment 2 of this invention The figure which shows the 1st example of the arrangement
  • FIG. 1 The figure which shows the 1st example of the arrangement
  • FIG. The figure which shows the 2nd example of the arrangement position of the metal material for joining determined by
  • Sectional drawing which shows the principal part structure of the probe which concerns on Embodiment 3 of this invention
  • Sectional drawing which shows the principal part structure of the probe which concerns on Embodiment 4 of this invention
  • Sectional drawing which shows the principal part structure of the probe which concerns on Embodiment 5 of this invention
  • the effect of eliminating or reducing the crosstalk of optical components (optical fibers and optical filters) at the probe tip can be obtained. Can be detected with high efficiency.
  • Embodiments 1, 2, and 5 by applying a surface treatment that forms a metal film on the surface of the tip region of the optical fiber (hereinafter referred to as Embodiments 1, 2, and 5), unnecessary light is incident on the optical fiber that has been subjected to the surface treatment. ⁇ Ejecting can be suppressed.
  • a metal film on both the outgoing (irradiation) and received optical fibers hereinafter, corresponding to the first, second, and fifth embodiments
  • unnecessary light can be reliably blocked, and the outgoing (irradiation), Crosstalk in the direction perpendicular to the optical axis between the received optical fibers can be eliminated.
  • forming a metal film on the outer periphery of the optical filter is very effective in eliminating crosstalk. Since the optical filter has a thickness in the optical axis direction, light may leak from the thickness portion. In the optical probe of the present invention, since the optical filter is provided for both emission (irradiation) and light reception, it is considered that the light leaked from the thickness portion may cause crosstalk. Such a problem can be solved by forming a metal film and shielding light.
  • a metal film may be formed on both the tip region of the optical fiber and the outer periphery of the optical filter (hereinafter, corresponding to Embodiments 2 to 5). Furthermore, a form in which these are joined (hereinafter, corresponding to Embodiments 3 and 4) is also preferable and can be employed. In this case, light shielding is particularly reliably performed.
  • this holding portion can be, for example, an exterior tube that holds a fiber bundle (hereinafter, corresponds to Embodiment 1).
  • the holding unit may be a so-called ferrule (hereinafter, corresponding to Embodiments 1 to 5).
  • ferrule hereinafter, corresponding to Embodiments 1 to 5
  • an embodiment the tip surface of the ferrule and the tip surface of the optical fiber are the same surface.
  • This also has the advantage of easy tip polishing. And especially in this case, the crosstalk between optical fibers can be eliminated.
  • Embodiments 2 to 5 when the tip surface of the ferrule and the tip surface of the optical fiber are not the same surface (hereinafter referred to as Embodiments 2 to 5), a metal film is formed on the surface of the tip region of the optical fiber, thereby crosstalk. Can be reduced.
  • the optical fiber is preferably a plastic fiber in order to achieve flexibility in the optical axis direction of the entire optical probe (hereinafter, corresponding to Embodiments 1 to 5).
  • the plastic jacket for the tip region of the optical fiber, it is preferable to remove the plastic jacket in order to form a metal film (hereinafter, corresponding to Embodiments 1, 2, and 5).
  • the configuration of the optical probe is preferably a configuration in which a metal frame is provided and the outer peripheral portion of the optical filter is joined to the metal frame (hereinafter, corresponding to Embodiments 2 to 5).
  • a metal frame is provided and the outer peripheral portion of the optical filter is joined to the metal frame
  • it is most reliable and preferable in terms of strength if it is bonded over the entire thickness direction of the optical filter (hereinafter, corresponding to Embodiments 2, 3, and 5).
  • metal plating and metallization treatment may be mentioned. Any method means a process of forming (metalizing) a metal film on the surface of an optical fiber or optical filter which is a non-metallic material.
  • FIG. 1 is a diagram illustrating a configuration example of a diagnostic system.
  • a diagnostic system 1 in FIG. 1 includes an endoscope 2, an endoscope processor 3, a base unit 4, an input device 5, monitors 6, 7, and a probe 10 according to Embodiment 1 of the present invention.
  • the endoscope 2 is provided at a long flexible endoscope body 21 formed so as to be capable of being introduced into a body cavity, and a proximal end portion (endoscope proximal end portion) 21a of the endoscope body 21.
  • the cable 23 that connects the endoscope main body 21 and the endoscope processor 3 via the operation unit 22 so as to communicate with each other.
  • the endoscope main body 21 has a flexibility that can be easily bent following the curvature of the body cavity when entering the inside of the body cavity over substantially the entire length thereof. Further, the endoscope body 21 has a mechanism (not shown) capable of bending a predetermined range (operable portion 21c) on the endoscope distal end portion 21b side at an arbitrary angle in accordance with the operation of the knob 22a of the operation portion 22.
  • the endoscope main body 21 has a camera CA, a light guide LG, and a channel CH as shown in a perspective view (FIG. 2) of the endoscope distal end portion 21b.
  • the light guide LG guides light (visible light) emitted from the illumination light source 31 of the endoscope processor 3 to the endoscope distal end portion 21b, and emits the light from the end face of the endoscope distal end portion 21b.
  • the camera CA is an electronic camera equipped with a solid-state imaging device, images an area illuminated by light emitted from the light guide LG, and sends the signal (imaging signal) to the image processing unit 32 of the endoscope processor 3. To transmit. An image (endoscopic image) based on the transmitted imaging signal is displayed on the monitor 6.
  • the channel CH is a lumen having a diameter of, for example, 2.6 mm formed in the endoscope main body 21 so as to communicate with the introduction port 22 b formed in the operation unit 22.
  • the probe main body 11 has an outer diameter (for example, 2.4 mm) that can be inserted into the channel CH of the endoscope 2, and is a long flexible wire that extends from the probe proximal end portion 11a to the probe distal end portion 11b. It is a shaped member and is introduced into the body cavity by insertion through the channel CH.
  • the probe body 11 is connected to the base unit 4 via connectors 11c and 11d provided at the probe base end portion 11a.
  • the probe body 11 guides the excitation light emitted from the laser 41 of the base unit 4 by the irradiation optical fiber 110 (see FIG. 3), and emits the light as irradiation light to the observation target site in the body cavity.
  • the laser 41 is a semiconductor laser, a solid laser, or the like, but it is preferable to use a semiconductor laser from the viewpoint of downsizing the apparatus.
  • the wavelength of the laser light is preferably 400 to 410 nm, 487 nm, 630 to 660 nm, 780 to 790 nm, 830 to 860 nm, 1290 to 1330 nm, or 1520 to 1580 nm.
  • the light source of the excitation light may not be the laser 41 but may be an LED (Light Emitting Diode) or the like.
  • the probe body 11 receives the reflected light from the site to be observed by the light receiving optical fiber 120 (see FIG. 3), and guides the light to the spectroscope 42 of the base unit 4.
  • the fluorescence or Raman scattered light contained in the light guided to the spectroscope 42 is subjected to spectrum analysis by the spectroscope 42.
  • the spectrum analysis result is subjected to image processing and the like by a CPU (Central Processing Unit) 43a of the computer 43 and displayed on the monitor 7 in the form of a graph or the like.
  • the CPU 43a may determine a medical condition and the like, and the determination result may be stored in the memory 43b and displayed on the monitor 7.
  • the execution and setting of various analyzes and determinations in the computer 43 can be performed by operating the input device 5 (for example, a keyboard or a mouse).
  • FIG. 3 is a diagram schematically showing the internal configuration of the probe 10 shown in FIG.
  • the irradiation optical fiber 110 (first optical fiber) and the light receiving optical fiber 120 (second optical fiber) are both long linear members having a total length of several meters and an outer diameter of about 100 to 300 ⁇ m, and are housed in the probe body 11. ing.
  • the irradiation optical fiber 110 is optically connected to the laser 41 of the base unit 4 by the connector 11c of the probe base end portion 11a.
  • the light receiving optical fiber 120 is optically connected to the spectroscope 42 of the base unit 4 by a connector 11d of the probe base end portion 11a.
  • the tip region (fiber tip region) 111 of the irradiation optical fiber 110 and the tip region (fiber tip region) 121 of the light receiving optical fiber 120 are held by the holding unit 130. Accordingly, the irradiation optical fiber 110 and the light receiving optical fiber 120 form a bundle, and the emission end face (that is, the emission surface of the irradiation light to the observation target part) and the incident end face (that is, the light reception surface of the reflected light from the observation target part). It is positioned.
  • the lengths of the fiber tip regions 111 and 121 held by the holding unit 130 are about 5 to 10 mm.
  • the main configuration of the probe 10 including the holding unit 130 that holds the fiber tip regions 111 and 121 will be described later.
  • the optical filter 141 (first optical filter) is located in the irradiation optical system including the irradiation optical fiber 110, and one end surface thereof is close to the emission end surface of the fiber tip region 111.
  • the optical filter 141 has a configuration in which a light absorbing material (or a light reflecting material) is dispersed in a transparent base material such as quartz glass, or a configuration in which a dielectric multilayer film is formed on a transparent substrate. Only the wavelength can be transmitted.
  • the optical filter 142 (second optical filter) is located in the light receiving optical system including the light receiving optical fiber 120, and one end surface thereof is close to the incident end surface of the fiber tip region 121.
  • the optical filter 142 has a configuration in which a light absorbing material (or light reflecting material) is dispersed in a transparent base material such as quartz glass, or a configuration in which a dielectric multilayer film is formed on a transparent substrate. Only the wavelength cannot be transmitted.
  • a lens 150 made of, for example, quartz glass or sapphire is disposed at the probe tip 11b in front of the optical filters 141 and 142.
  • the lens 150 is equipped for the purpose of improving the air tightness of the optical path, the external light reception, the external light reception, and the optical path.
  • the lens 150 may be a plurality of lens groups.
  • the fiber tip regions 111 and 121, the holding unit 130, the optical filters 141 and 142, and the lens 150 are housed in a cylindrical metal frame (not shown) having a length of about 10 to 15 mm.
  • the configuration of the irradiation optical fiber 110 and the light receiving optical fiber 120 excluding the fiber tip regions 111 and 121 has a three-layer structure including a core, a clad, and a plastic jacket, as shown in the sectional view of FIG.
  • the core and the clad are made of a transparent material such as quartz glass, and the core has a higher refractive index than that of the clad, so that light is confined in the core and propagates.
  • the core and clad of the irradiation optical fiber 110 and the light receiving optical fiber 120 are made of a plastic that is resistant to bending (that is, the irradiation optical fiber 110 and the light receiving optical fiber). 120 is preferably configured as a plastic fiber).
  • the plastic jacket covers the outer periphery of the clad for reinforcement of the irradiation optical fiber 110 and the light receiving optical fiber 120, improvement of mechanical characteristics, and the like.
  • FIG. 5 is a cross-sectional view showing the main configuration of the probe 10 including the holding portion 130 that holds the fiber tip regions 111 and 121.
  • the holding unit 130 includes a ferrule 132 and an outer skin 134.
  • the ferrule 132 is a member made of, for example, metal, quartz glass, zirconia, or the like.
  • the ferrule 132 is formed with a hole into which the irradiation optical fiber 110 and each light receiving optical fiber 120 can be inserted.
  • the irradiation optical fiber 110 and the light receiving optical fiber 120 are held by the ferrule 132 by being inserted into this hole.
  • the outer skin 134 is a thin tube made of vinyl, for example, and covers the outer periphery of the ferrule 132.
  • the irradiation optical fiber 110 and the light receiving optical fiber 120 held by the holding unit 130 are arranged so as to form a bundle in contact with each other or close to each other for the purpose of improving the light receiving efficiency and reducing the probe diameter.
  • the light receiving optical fiber 120 disposed so as to surround the irradiation optical fiber 110 has the three-layer structure shown in FIG. 4 in the fiber tip region 121 as well as the region other than the fiber tip region 121.
  • the plastic jacket corresponding to the outer layer of the three-layer structure is removed in the fiber tip region 111, and the portion (jacket removing portion) is made of metal.
  • Plating is applied.
  • the thickness of the metal plating layer 112 is about several ⁇ m to 100 ⁇ m, and can be adjusted by the length of the metal plating process, the number of times the metal plating process is repeated, or the method of the metal plating process. Therefore, the fiber outer diameter can be set to an arbitrary diameter.
  • examples of the metal material used in the plating process and constituting the metal plating layer 112 include Ni, Ti, Au, and the like.
  • optical fibers having a plastic jacket are used as the irradiation optical fiber 110 and the light receiving optical fiber 120.
  • a plastic jacket type optical fiber is advantageous in comparison with a metal jacket type optical fiber in that it is not only inexpensive but also has a low possibility of deterioration or peeling when repeatedly bent.
  • the use of a plastic jacket type optical fiber can ensure the flexibility of the probe 10 and facilitate the handling of the probe 10 during production, packaging, and treatment.
  • the usable fiber outer diameter is limited by the connector.
  • plastic jacket type optical fibers have a wide variety of fiber outer diameters, it is easy to obtain optical fibers suitable for the connectors used.
  • the plastic jacket type optical fiber to be used is plated with metal.
  • Metal plating can be applied to a desired location. Therefore, as in the present embodiment, the metal plating layer 112 can be formed only in the fiber tip region 111 of the irradiation optical fiber 110. Therefore, the metal plating layer 112 does not become an obstacle to the above effect due to the use of a plastic jacket type optical fiber. Further, since the metal plating layer 112 is formed in the fiber tip region 111, it is possible to prevent light from leaking out of the fiber tip region 111 by the metal plating layer 112.
  • the light shielding property capable of preventing crosstalk between the irradiation optical fiber 110 and the light receiving optical fiber 120 is formed so that the irradiation optical fiber 110 and the light receiving optical fiber 120 form a bundle (that is, in contact with or close to each other). This can be ensured in the fiber tip region 111, which is a held region.
  • the fiber outer diameter does not become a problem in the process of metal plating, it is possible to use optical fibers of various sizes.
  • the bundle of the irradiation optical fiber 110 and the light receiving optical fiber 120 is not necessarily within the tube. It may not be kept in close contact.
  • the filling rate of the irradiation optical fiber 110 and the light receiving optical fiber 120 within the inner diameter of the tube is increased by thickening the diameter of the irradiation optical fiber 110 by performing metal plating on the fiber tip region 111 of the irradiation optical fiber 110.
  • the stability of the bundle of the irradiation optical fiber 110 and the light receiving optical fiber 120 in the tube can be improved.
  • the plastic jacket is removed from the fiber tip region 111, and the jacket removing portion is subjected to metal plating.
  • metal plating may be applied to the outer peripheral portion without removing the plastic jacket, but removing the plastic jacket is advantageous in terms of reducing the probe diameter.
  • the ferrule 132 used in the example shown in FIG. 5 is not used. Accordingly, the light receiving optical fiber 120 surrounding the irradiation optical fiber 110 is bonded to the irradiation optical fiber 110 with an adhesive, for example, in contact with the metal plating layer 112 on the outer periphery of the irradiation optical fiber 110 and inserted into the outer skin 134. ing. In this configuration, a positioning member such as the ferrule 132 is not required, and the irradiation optical fiber 110 can be easily arranged at the center of the probe 10. In addition, since the ferrule 132 is not used, the probe diameter can be reduced, and the probe outer diameter can be adjusted by adjusting the thickness of the metal plating layer 112.
  • the second modification shown in FIG. 7 is similar to the example shown in FIG. 6, but the plastic jacket is removed from the fiber tip region 121 of the light receiving optical fiber 120, and a metal plating layer 122 is formed on the jacket removal portion by metal plating. This is different from the example shown in FIG. In this configuration, since the metal plating is applied to both the irradiation optical fiber 110 and the light receiving optical fiber 120, the light shielding property between the irradiation optical fiber 110 and the light receiving optical fiber 120 can be further improved.
  • the third modification shown in FIG. 8 is similar to the example shown in FIG. 7, but the plastic jacket is not removed in the fiber tip region 111 of the irradiation optical fiber 110, leaving the three-layer structure shown in FIG. This is different from the example shown in FIG. In this configuration, even if light leaks from the fiber tip region 111 of the irradiation optical fiber 110, the metal plating layer 122 can prevent this light from entering the fiber tip region 121 of the light receiving optical fiber 120.
  • the number of irradiation optical fibers 110 and light receiving optical fibers 120 can be changed as appropriate.
  • FIG. 9 is a cross-sectional view showing the main configuration of the probe 15 according to the present embodiment that can be used in the above-described diagnostic system 1.
  • the probe 15 has a probe main body 11 that extends from the probe proximal end portion 11 a to the probe distal end portion 11 b, can be inserted into the channel CH of the endoscope 2, and can be connected to the base unit 4, similarly to the probe 10 described above.
  • the irradiation optical fiber 211 (first optical fiber) is a long and narrow optical fiber having the three-layer structure shown in FIG. In the tip region of the irradiation optical fiber 211, the plastic jacket corresponding to the outer layer of the three-layer structure is removed, and the metal plating layer 112 is formed in that portion.
  • the irradiation optical fiber 211 emits the irradiation light to the site to be observed from the fiber tip portion 211a (first fiber tip portion).
  • the light receiving optical fiber 212 (second optical fiber) is a long and narrow optical fiber having the three-layer structure of FIG.
  • the metal plating layer 112 is also formed in the tip region of the light receiving optical fiber 212 as in the case of the irradiation optical fiber 211.
  • the optical fiber for light reception 212 receives reflected light from the observation target part including Raman scattered light generated with respect to the irradiation light by the living tissue of the observation target part at the fiber tip part 212a (second fiber tip part). .
  • the irradiation optical fiber 211 and the light receiving optical fiber 212 are held by a ferrule 213 (holding unit) made of, for example, metal, quartz glass, zirconia, or the like.
  • the ferrule 213 is fitted into a cylindrical metal frame 214 (for example, made of stainless steel) having a length of about 5 to 10 mm.
  • a lens 215 having a circular cross section (not shown) is disposed at the probe tip 11b and is held in the metal frame 214.
  • the lens 215 is equipped for the purpose of improving the light irradiation to the outside, the reception of the light from the outside, and the air tightness of the optical path, and is made of, for example, quartz glass or sapphire.
  • a method for holding the lens 215 a conventionally known method can be employed.
  • the lens 215 has a convex surface on the probe base end 11a side as shown in FIG. 9, but it may be a flat surface. Although the surface on the tip 11b side is formed in a flat shape, it may be convex.
  • the lens 215 may be a plurality of lens groups.
  • Optical filters 221 and 222 are disposed between the fiber tip portions 211 a and 212 a and the lens 215, and are housed in the metal frame 214.
  • Each of the optical filters 221 and 222 has a semicircular cross section (not shown) so as to form a circular cross section by combination.
  • the optical filter 221 (first optical filter) is located in the irradiation optical system including the irradiation optical fiber 211, and one end face thereof is close to the fiber tip 211 a of the irradiation optical fiber 211.
  • the internal configuration and wavelength transmission characteristics of the optical filter 221 are the same as those of the optical filter 141 described above.
  • the optical filter 222 (second optical filter) is located in the light receiving optical system including the light receiving optical fiber 212, and one end face thereof is close to the fiber tip 212 a of the light receiving optical fiber 212.
  • the internal configuration and wavelength transmission characteristics of the optical filter 222 are the same as those of the optical filter 142 described above.
  • the filter outer peripheral part 221a which is the outer peripheral part of the semicircular cross section of the optical filter 221 is subjected to metallization processing on the whole. Therefore, a metallized film 231 is formed on the filter outer peripheral part 221a.
  • the metallized film thickness can be adjusted by the number of times the metallization process is repeated.
  • the metal material used in the metallization process and constituting the metallization film 231 is preferably Ni, Ti or Au.
  • the metal material is preferably a single material, but may be an alloy composed of a plurality of materials. However, when an alloy is used, the composition is preferably known.
  • Various methods can be adopted as the metallization process. For example, techniques by vapor deposition such as physical vapor deposition and chemical vapor deposition can be used. Further, a method of bringing a molten metal into contact, a method of electroless plating, a method of combining these, a method of further combining electrolytic plating with the method of combining them, or
  • the optical filters 221 and 222 are joined to each other by the joining metal material 241 that is the brazing material or solder used for brazing or soldering.
  • an airtight joint is formed between the optical filter 221 of the irradiation optical system and the optical filter 222 of the light receiving optical system by metallization processing and brazing or soldering. Therefore, airtightness between the optical filter 221 of the irradiation optical system and the optical filter 222 of the light receiving optical system can be ensured without using an adhesive.
  • Adhesion with an adhesive is conventionally known as a general adhesion method for ensuring airtightness, but an adhesive is usually a plastic that generates fluorescence and Raman scattered light with respect to irradiation light. It is not necessarily suitable for use in the optical path.
  • an adhesive mainly made of plastic is not used at the joint between the optical filters 221 and 222.
  • production of the Raman scattered light and fluorescence resulting from use of an adhesive agent can be prevented reliably.
  • the filter outer peripheral part 221a of the irradiation optical system and the filter outer peripheral part 222a of the light receiving optical system are both subjected to metallization processing. Therefore, leakage of light from the filter outer peripheral portion 221a of the irradiation optical system to the filter outer peripheral portion 222a of the light receiving optical system is caused by the metallized film 231 interposed between the optical filter 221 of the irradiation optical system and the optical filter 222 of the light receiving optical system.
  • the optical filters 221 and 222 and the metal frame 214 are also joined by the joining metal material 241.
  • an airtight joint is formed between the optical filters 221 and 222 and the metal frame 214 by metallization and brazing or soldering. Therefore, airtightness can be ensured between the optical filters 221 and 222 and the metal frame 214 without using an adhesive mainly made of plastic. Thereby, it can prevent reliably that a Raman scattered light and fluorescence generate
  • the joining metal material 241 is preferably a single material such as Ag or Cu, but may be an alloy composed of a plurality of materials. However, when an alloy is used, the composition is preferably known.
  • the metallized film thickness can be adjusted by the number of times the metallization process is repeated. That is, the metallized film thickness can be arbitrarily set.
  • the bonding metal material 241 interposed between the optical filters 221 and 222 and the metal frame 214 does not wrap around the entire thickness direction of the optical filters 221 and 222. You may arrange
  • the joining metal material 241 shown in FIG. 10A can be formed by the following method, for example. First, before attaching the optical filters 221 and 222 to the metal frame 214, a metal paste is disposed in the vicinity of the ferrule 213. After the optical filters 221 and 222 are attached to the metal frame 214, the metal paste is melted by heating, and the metal paste is infiltrated into the gap between the metallized film 231 and the metal frame 214 using a capillary phenomenon. Then, after the metal paste penetrates into the gap, the metal paste is cooled.
  • the bonding metal member 241 that covers the filter outer peripheral portions 221a and 222a only in a part of the thickness direction of the optical filters 221 and 222 is on the lens 215 side (in other words, the probe tip portion 11b) as shown in FIG. 10B. It may be.
  • the metallized film thickness is set to, for example, less than 100 ⁇ m, particularly about 10 ⁇ m, the metallization processing cost can be suppressed at a low cost.
  • the bonding metal material 241 interposed between the optical filters 221 and 222 and the metal frame 214 wraps around the entire area in the thickness direction of the optical filters 221 and 222. It is preferable that the filter is disposed so as to cover the filter outer peripheral portions 221a and 222a.
  • FIG. 11 is a cross-sectional view showing the main configuration of the probe according to Embodiment 3 of the present invention.
  • the main configuration of the probe 20 of the present embodiment shown in FIG. 11 is similar to the main configuration of the probe 15 of the second embodiment shown in FIG. Therefore, in the present embodiment, the same or corresponding components as those described in the second embodiment are denoted by the same reference numerals, and detailed description thereof is omitted, and the difference from the second embodiment. The explanation will be focused on.
  • the irradiation optical fiber 211 and the light receiving optical fiber 212 protrude from the ferrule 213 toward the probe tip 11b. Therefore, protrusions 211 b and 212 b extending from the ferrule 213 to the optical filters 221 and 222 are formed in the irradiation optical fiber 211 and the light receiving optical fiber 212.
  • an epoxy-based adhesive can be used for bonding between the ferrule 213 and the irradiation optical fiber 211 and the light-receiving optical fiber 212, but there is a possibility that the adhesive protrudes to the protruding portions 211b and 212b.
  • the fiber outer peripheral portions 211c and 212c which are the outer peripheral portions of the protruding portions 211b and 212b, are subjected to the same metallization processing as the optical filters 221 and 222, respectively. Therefore, a metallized film 232 is formed on the fiber outer peripheral portions 211c and 212c.
  • the metallized film 232 can reliably prevent the optical path from being affected by the adhesive protruding from the ferrule 213.
  • FIG. 12 is a cross-sectional view showing the main configuration of the probe according to Embodiment 4 of the present invention.
  • the main configuration of the probe 30 of the present embodiment shown in FIG. 12 is similar to the main configuration of the probes 15 and 20 of the second and third embodiments shown in FIGS. Therefore, in this embodiment, the same or corresponding components as those described in Embodiments 2 and 3 are denoted by the same reference numerals, and detailed description thereof is omitted, and Embodiments 2 and 3 are omitted. The difference will be mainly described.
  • the optical filters 221 and 222 are equivalent to the irradiation optical fiber 211 and the light receiving optical fiber 212 so that the filter outer peripheral parts 221a and 222a are flush with the fiber outer peripheral parts 211c and 212c. Is processed into a size (cross section).
  • the filter outer peripheral portions 221a and 222a and the fiber outer peripheral portions 211c and 212c having the metallized films 231 and 232 are brazed or soldered, respectively. Therefore, the bonding between the optical filter 221 and the irradiation optical fiber 211 and the bonding between the optical filter 222 and the light receiving optical fiber 212 are formed by the bonding metal materials 241 and 242.
  • an airtight joint by metallization processing and brazing or soldering is formed between the optical filters 221 and 222, the irradiation optical fiber 211, and the light receiving optical fiber 212. Therefore, the optical filters 221 and 222 are directly connected to the irradiation optical fiber 211 and the light receiving optical fiber 212. Therefore, it is possible to prevent a gap in which noise light may circulate between the optical filters 221 and 222, the irradiation optical fiber 211, and the light receiving optical fiber 212.
  • the irradiation optical fiber 211 and the light receiving optical fiber 212 have the metallized film 232, it is not necessary to form a metal plating layer.
  • FIG. 13 is a cross-sectional view showing the main configuration of the probe according to Embodiment 5 of the present invention.
  • the main configuration of the probe 40 of the present embodiment shown in FIG. 13 is similar to the main configuration of the probes 15, 20, 30 of the second to fourth embodiments shown in FIGS. Therefore, in the present embodiment, the same or corresponding components as those described in Embodiments 2 to 4 are denoted by the same reference numerals, and detailed description thereof is omitted, and Embodiments 2 to 4 are omitted. The difference will be mainly described.
  • the fiber tip portion 212a is disposed closer to the probe tip portion 11b than the fiber tip portion 211a, so that the length of the light receiving optical fiber 212 is the length of the irradiation optical fiber 211. It is longer than that.
  • vignetting can be prevented from occurring in the light emitted from the irradiation optical fiber 211 and the light incident on the light receiving optical fiber 212.
  • light emitted from an optical fiber or light incident on an optical fiber is divergent light or convergent light.
  • NA numerical aperture
  • NA is about 0.2.
  • vignetting may occur due to the optical filter 221 disposed in front of the irradiation optical fiber 211 and the metallized film 231 and the like around the optical filter 221 to hinder improvement in light receiving efficiency.
  • the occurrence of vignetting can be prevented by separating the irradiation optical fiber 211 and the light receiving optical fiber 212 from each other.
  • the irradiation optical fiber 211 can be relatively distant from the observation target part, and the light receiving optical fiber 212 can be relatively close. Therefore, the emitted light from the irradiating optical fiber 211 can be applied to the observation target area in a wide area, and the light can be condensed on the light receiving optical fiber 212.
  • a ferrule 213 may be interposed between the irradiation optical fiber 211 and the light receiving optical fiber 212 so that they are separated from each other.
  • both the irradiation with the irradiation optical fiber 211 and the light reception with the light receiving optical fiber 212 can be performed with the full NA of the fiber, and the efficiency of both irradiation and light reception can be improved.

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Abstract

La présente invention porte sur une sonde optique qui comporte : une première fibre optique qui a une première partie d'extrémité avant de fibre qui émet une lumière d'irradiation ; une seconde fibre optique qui a une seconde partie d'extrémité avant de fibre qui reçoit une lumière fluorescente ou une lumière de diffusion Raman ; un premier filtre optique qui est agencé sur la première partie d'extrémité avant de fibre ; et un second filtre optique qui est agencé sur la seconde partie d'extrémité avant de fibre. Au moins l'un de la première fibre optique, de la seconde fibre optique, du premier filtre optique et du second filtre optique est soumis à un processus de formation d'un film métallique.
PCT/JP2012/006835 2011-10-25 2012-10-25 Sonde optique et procédé de fabrication de celle-ci WO2013061590A1 (fr)

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Cited By (11)

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CN104013377A (zh) * 2014-06-10 2014-09-03 上海大学 可弯折变形光纤束内窥镜管线
JP2015056278A (ja) * 2013-09-12 2015-03-23 中村　正一 医療用照明装置
KR101790561B1 (ko) 2016-08-10 2017-10-26 경희대학교 산학협력단 라만 광섬유 탐침 장치
KR101806745B1 (ko) * 2016-11-04 2017-12-07 경희대학교 산학협력단 라만 프로브장치
KR101872127B1 (ko) * 2016-12-14 2018-07-02 한국광기술원 라만 신호를 제거한 광섬유 모듈
KR20180073060A (ko) * 2016-12-22 2018-07-02 테라셈 주식회사 프로브 유닛, 이것을 포함하는 광학 영상 장치, 및 광학 영상 장치의 제어 방법
KR101942911B1 (ko) 2017-07-24 2019-01-28 주식회사 에스에스솔루션 표면증강 라만산란에 의한 기체 검출 광센서
CN110235036A (zh) * 2017-01-27 2019-09-13 瑞尼斯豪公司 激光直写与化学刻蚀和光学器件
EP3553502A4 (fr) * 2016-12-08 2020-07-22 Nuctech Company Limited Système et procédé d'inspection de sécurité de type sans contact
JPWO2021215433A1 (fr) * 2020-04-24 2021-10-28
US11860508B2 (en) 2020-04-24 2024-01-02 Panasonic Intellectual Property Management Co., Ltd. Light-emitting system

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CN107870399A (zh) * 2016-09-27 2018-04-03 福州高意光学有限公司 一种特殊光接受结构

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WO2011062087A1 (fr) * 2009-11-17 2011-05-26 コニカミノルタオプト株式会社 Sonde pour dispositif optique de mesure d'image tomographique et procédé d'ajustement de sonde

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015056278A (ja) * 2013-09-12 2015-03-23 中村　正一 医療用照明装置
CN104013377A (zh) * 2014-06-10 2014-09-03 上海大学 可弯折变形光纤束内窥镜管线
KR101790561B1 (ko) 2016-08-10 2017-10-26 경희대학교 산학협력단 라만 광섬유 탐침 장치
KR101806745B1 (ko) * 2016-11-04 2017-12-07 경희대학교 산학협력단 라만 프로브장치
EP3553502A4 (fr) * 2016-12-08 2020-07-22 Nuctech Company Limited Système et procédé d'inspection de sécurité de type sans contact
US10823676B2 (en) 2016-12-08 2020-11-03 Nuctech Company Limited Non-contact type security inspection system and method
KR101872127B1 (ko) * 2016-12-14 2018-07-02 한국광기술원 라만 신호를 제거한 광섬유 모듈
KR20180073060A (ko) * 2016-12-22 2018-07-02 테라셈 주식회사 프로브 유닛, 이것을 포함하는 광학 영상 장치, 및 광학 영상 장치의 제어 방법
KR101944760B1 (ko) 2016-12-22 2019-04-17 주식회사 모멘텀컨설팅 프로브 유닛, 이것을 포함하는 광학 영상 장치, 및 광학 영상 장치의 제어 방법
CN110235036A (zh) * 2017-01-27 2019-09-13 瑞尼斯豪公司 激光直写与化学刻蚀和光学器件
CN110235036B (zh) * 2017-01-27 2021-02-26 瑞尼斯豪公司 激光直写与化学刻蚀和光学器件
KR101942911B1 (ko) 2017-07-24 2019-01-28 주식회사 에스에스솔루션 표면증강 라만산란에 의한 기체 검출 광센서
JPWO2021215433A1 (fr) * 2020-04-24 2021-10-28
WO2021215433A1 (fr) * 2020-04-24 2021-10-28 パナソニックＩｐマネジメント株式会社 Système d'éclairage
US11860508B2 (en) 2020-04-24 2024-01-02 Panasonic Intellectual Property Management Co., Ltd. Light-emitting system
JP7411941B2 (ja) 2020-04-24 2024-01-12 パナソニックＩｐマネジメント株式会社 照明システム

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