WO2014111990A1 - Sonde, dispositif de spectrométrie et système de diagnostic - Google Patents

Sonde, dispositif de spectrométrie et système de diagnostic Download PDF

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Publication number
WO2014111990A1
WO2014111990A1 PCT/JP2013/006634 JP2013006634W WO2014111990A1 WO 2014111990 A1 WO2014111990 A1 WO 2014111990A1 JP 2013006634 W JP2013006634 W JP 2013006634W WO 2014111990 A1 WO2014111990 A1 WO 2014111990A1
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WO
WIPO (PCT)
Prior art keywords
light
probe
optical fiber
measurement
optical
Prior art date
Application number
PCT/JP2013/006634
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English (en)
Japanese (ja)
Inventor
岩坂　喜久男
夏野　靖幸
Original Assignee
コニカミノルタ株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by コニカミノルタ株式会社 filed Critical コニカミノルタ株式会社
Priority to JP2014557186A priority Critical patent/JP6237648B2/ja
Publication of WO2014111990A1 publication Critical patent/WO2014111990A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/07—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00064—Constructional details of the endoscope body
    • A61B1/00071—Insertion part of the endoscope body
    • A61B1/0008—Insertion part of the endoscope body characterised by distal tip features
    • A61B1/00096—Optical elements

Definitions

  • the present invention relates to a probe used for measuring a region to be measured in a body lumen by spectroscopy, and a spectroscopic measurement device connectable to the probe.
  • a long probe is introduced into the lumen via the endoscope channel, Performing light projection and light reception using a probe is conventionally known.
  • a relatively narrow-band excitation light (hereinafter referred to as “measurement light”) is irradiated to the measurement target region via a probe, and appears from a measurement target region in a wavelength region different from that of the measurement light.
  • Radiation light including fluorescence or Raman scattered light (hereinafter referred to as “measurement target light”) is emitted, and this radiation light is received by the probe.
  • the light received by the probe is detected by a spectroscopic measurement device connected to the probe.
  • Spectral data obtained as a detection result can be used to determine the state of a lesion or the like of a measurement target site.
  • an optical filter may be installed in a probe that uses both an optical fiber for irradiating measurement light (irradiation optical fiber) and an optical fiber for receiving measurement target light (optical fiber for light reception).
  • an optical filter that passes only the wavelength of measurement light is installed near the tip of the optical fiber for irradiation, and an optical filter that cuts only the wavelength of measurement light (optical filter for light reception) is used for light reception.
  • an optical filter that passes only the wavelength of measurement light is installed near the tip of the optical fiber for irradiation
  • an optical filter that cuts only the wavelength of measurement light is used for light reception.
  • Patent Document 1 As a light shielding structure for preventing such crosstalk, for example, there is one proposed in Patent Document 1.
  • a light receiving optical fiber is disposed around an irradiation optical fiber.
  • the tip of the optical fiber for irradiation is covered with a stainless steel pipe for shielding light between the fibers, but a part of this pipe protrudes forward from the tip of the fiber, and an optical filter for irradiation is inserted there.
  • the light receiving optical filter disposed at the tip of the light receiving optical fiber is formed in a donut shape and is disposed so as to surround the outer periphery of the pipe. With this structure, the irradiation side and the light receiving side are completely separated from each other.
  • the NA (Numerical Aperture) of an optical fiber is generally about 0.2 to 0.6 depending on the material. That is, the light (including measurement light) emitted from the irradiation optical fiber is divergent light, and the measurement target light incident on the light receiving optical fiber is convergent light.
  • the pipe is shortened in order to reduce reflection by the pipe, it is necessary to make the glass plate used for the optical filter thinner. However, when the glass plate is thinned, its strength is lowered, and it is difficult to manufacture an optical filter.
  • An object of the present invention is to provide a probe, a spectroscopic measurement device, and a diagnostic system that can easily manufacture a filter and can improve the irradiation efficiency of measurement light and the light reception efficiency of measurement target light.
  • the probe according to the present invention comprises: 1st optics which is arrange
  • a second optical filter that passes through;
  • the spectrometer of the present invention is Spectral processing is performed on the light that can be connected to the probe and that has passed through the second optical filter of the probe.
  • the diagnostic system of the present invention comprises: And a spectroscopic measurement device connected to the probe for performing spectroscopic processing on the light transmitted through the second optical filter of the probe.
  • an optical probe, a spectroscopic measurement apparatus, and a diagnostic system that are easy to manufacture a filter and that can improve the irradiation efficiency of measurement light and the light reception efficiency of measurement target light.
  • a diagnostic system 1 shown in FIG. 1 includes an endoscope 2, an endoscope processor 3, a base unit 4, an input device 5, monitors 6 and 7, and a probe 10.
  • the base unit 4 functions as a spectroscopic measurement device.
  • the endoscope 2 is provided at a long flexible endoscope body 21 formed so as to be capable of being introduced into a lumen, and a proximal end portion (endoscope proximal end portion) 21a of the endoscope body 21.
  • the cable 23 that connects the endoscope main body 21 and the endoscope processor 3 via the operation unit 22 in a communicable manner.
  • the endoscope main body 21 has flexibility over the substantially entire length of the endoscope main body 21 so that it can be easily bent following the curvature of the lumen when entering the inside of the lumen. Further, the endoscope body 21 has a mechanism (not shown) capable of bending a predetermined range (operable portion 21c) on the endoscope distal end portion 21b side at an arbitrary angle in accordance with the operation of the knob 22a of the operation portion 22.
  • the endoscope body 21 includes a camera CA, a light guide LG, and a channel CH as shown in a perspective view (FIG. 2) of the endoscope distal end portion 21b.
  • the light guide LG guides light (visible light) emitted from the illumination light source 31 of the endoscope processor 3 to the endoscope distal end portion 21b, and emits the light from the end face of the endoscope distal end portion 21b.
  • the camera CA is an electronic camera equipped with a solid-state imaging device, images an area illuminated by light emitted from the light guide LG, and sends the signal (imaging signal) to the image processing unit 32 of the endoscope processor 3. To transmit. An image (endoscopic image) based on the transmitted imaging signal is displayed on the monitor 6.
  • the channel CH is a lumen having a diameter of, for example, 2.6 [mm] formed in the endoscope main body 21 so as to communicate with the introduction port 22b formed in the operation unit 22.
  • Various devices for observing, diagnosing, and operating a lesion can be inserted into the channel CH.
  • a lesion such as cancer is obtained by irradiating measurement light (excitation light) on a measurement target site in a lumen and acquiring radiation emitted from the measurement target site. It is possible to insert a probe main body 11 capable of inspecting the status of a lesioned part such as the presence / absence of a part, its type, and the degree of lesion progression.
  • the probe main body 11 has an outer diameter (for example, 2.4 [mm]) that can be inserted into the channel CH of the endoscope 2, and is a long and flexible piece that extends from the probe proximal end portion 11a to the probe distal end portion 11b. It is a flexible linear member and is introduced into the lumen by insertion into the channel CH.
  • the probe body 11 is connected to the base unit 4 via connectors 11c and 11d provided on the probe base end portion 11a.
  • the probe body 11 guides the measurement light emitted from the laser 41 of the base unit 4 by the irradiation optical fiber 110 (see FIG. 3), and uses the measurement light as the irradiation light to the measurement target site in the lumen. Exit.
  • the laser 41 is a semiconductor laser, a solid laser, or the like, but it is preferable to use a semiconductor laser from the viewpoint of downsizing the apparatus.
  • the wavelength of the laser light is 400 to 410 [nm], 487 [nm], 630 to 660 [nm], 780 to 790 [nm], 830 to 860 [nm], 1290 to 1330 [nm] or 1520.
  • a wavelength of ⁇ 1580 [nm] is preferred.
  • the light source of the measurement light may not be the laser 41, but may be an LED (Light Emitting Diode), a light bulb (for example, a xenon lamp or a halogen lamp), or the like.
  • the probe body 11 receives the measurement target light (that is, fluorescence or Raman scattered light) included in the radiated light emitted from the measurement target site when the measurement target site is irradiated with the measurement light, and receives the optical fiber 120 for receiving light (FIG. 3).
  • the measurement target light is guided to the spectroscope 42 of the base unit 4.
  • the measurement target light guided to the spectroscope 42 is subjected to spectrum analysis processing (spectral processing) by the spectroscope 42.
  • the spectrum analysis result is subjected to image processing or the like by a CPU (Central Processing Unit) 43a of the computer 43 and displayed on the monitor 7 in the form of a graph or the like.
  • a CPU Central Processing Unit
  • the CPU 43a may determine a medical condition and the like, and the determination result may be stored in the memory 43b and displayed on the monitor 7.
  • the execution and setting of various analyzes and determinations in the computer 43 can be performed by operating the input device 5 (for example, a keyboard or a mouse).
  • FIG. 3A is a diagram schematically showing the internal configuration of the probe 10 shown in FIG.
  • FIG. 4 is an exploded perspective view schematically showing the internal configuration of the probe 10.
  • the irradiation optical fiber 110 (first optical fiber) and the light receiving optical fiber 120 (second optical fiber) are both long linear members having a total length of several meters and an outer diameter of about 100 to 300 [ ⁇ m]. It is stored in.
  • the irradiation optical fiber 110 is optically connected to the laser 41 of the base unit 4 by the connector 11c of the probe base end portion 11a.
  • the light receiving optical fiber 120 is optically connected to the spectroscope 42 of the base unit 4 by a connector 11d of the probe base end portion 11a.
  • the tip region (fiber tip region) 111 of the irradiation optical fiber 110 and the tip region (fiber tip region) 121 of the light receiving optical fiber 120 are held by a ferrule 130 (holding unit) disposed behind the optical filters 141 and 142. Yes.
  • the irradiation optical fiber 110 and the light receiving optical fiber 120 form a bundle, and the emission end face (that is, the emission surface of the measurement light to the measurement target part) and the incident end face (that is, reception of the measurement target light from the measurement target part). Surface) is accurately positioned relative to the ferrule 130.
  • the lengths of the fiber tip regions 111 and 121 held by the ferrule 130 are about 5 to 10 [mm].
  • the ferrule 130 is a member made of an inorganic material such as metal, quartz glass or zirconia.
  • the ferrule 130 is formed with holes 130c and 130d into which the irradiation optical fiber 110 and the light receiving optical fiber 120 can be inserted.
  • the irradiation optical fiber 110 and the light receiving optical fiber 120 are held by the ferrule 130 by being inserted into the holes 130c and 130d.
  • the irradiation optical fiber 110 and the light receiving optical fiber 120 held by the ferrule 130 are arranged so as to form a bundle in contact with or close to each other for the purpose of improving the light receiving efficiency and reducing the diameter of the probe 11.
  • the optical filter 141 (first optical filter) is located in the irradiation optical system including the irradiation optical fiber 110, and one end surface thereof is disposed in front of the emission end surface of the fiber tip region 111.
  • the optical filter 141 has a configuration in which a light absorbing material (or light reflecting material) is dispersed in a transparent base material such as quartz glass, or a configuration in which a dielectric multilayer film is formed on a transparent substrate. Only wavelength components can be transmitted.
  • the optical filter 142 (second optical filter) is located in the light receiving optical system including the light receiving optical fiber 120, and one end surface thereof is disposed in front of the incident end surface of the fiber tip region 121.
  • the optical filter 142 has a configuration in which a light absorbing material (or a light reflecting material) is dispersed in a transparent base material such as quartz glass, or a configuration in which a dielectric multilayer film is formed on a transparent substrate. Wavelength components outside the wavelength range corresponding to the wavelength can be transmitted.
  • the outer periphery of the optical filters 141 and 142 has a circular part cut off in a straight line, that is, a flat portion. It is formed in a D-cut shape having 141a, 142a and circular portions 141b, 142b.
  • a lens 150 made of, for example, quartz glass or sapphire is disposed at the probe tip 11b in front of the optical filters 141 and 142.
  • the lens 150 is equipped for the purpose of irradiating the measurement light to the outside, receiving the radiated light from the outside, and improving the air tightness and water tightness of the optical path.
  • the lens 150 may be a plurality of lens groups.
  • a flat plate-shaped light shielding member 143 made of metal (for example, stainless steel) is disposed between the optical filter 141 and the optical filter 142. More specifically, the light shielding member 143 is disposed so as to be sandwiched between the flat portion 141 a of the optical filter 141 and the flat portion 142 a of the optical filter 142.
  • the light shielding member 143 has a light shielding property with respect to the measurement light irradiated to the measurement target part and the radiated light (including the measurement target light) emitted from the measurement target part.
  • the thickness d of the light shielding member 143 is, for example, 0.01 to 0.1 [mm].
  • the front end surfaces of the optical filters 141 and 142 and the front end surface of the light shielding member 143 are arranged so that the positions in the probe longitudinal direction are aligned.
  • these members are arranged on the same surface so that these members are arranged closer to the lens 150. This contributes to making the probe 10 compact.
  • the lens 150, the optical filters 141 and 142, and the ferrule 130 are accommodated in a metal holder 151 as shown in FIG. 3B.
  • the holder 151 has a through hole of the same diameter inside, and a flange portion 151a that forms an opening having a smaller diameter than the through hole on the tip side.
  • a connecting portion 151 b having a reduced outer diameter is provided on the rear end side of the holder 151.
  • a lens 150, interval tubes 152 and 153 for adjusting the interval, optical filters 141 and 142, and a ferrule 130 are sequentially inserted into the through hole of the holder 151 from the rear end side, and the fixing member 154 is inserted into the connection portion 151b of the holder 151.
  • Each member is fixed to the holder 151 by fitting into the holder 151. Then, the holder 151 and the tube member 155 are covered with a flexible resin tube member 155 so as to cover the optical fibers 110 and 120 and the fixing member 154 on the connection portion 151b at the rear end of the holder 151. Connecting. Thus, the probe 10 is assembled.
  • the probe 10 according to the present embodiment is disposed in front of the emission end face of the irradiation optical fiber 110 and irradiates the measurement target site in the lumen out of the light output from the irradiation optical fiber 110.
  • the optical filter 141 that transmits the wavelength component of the measurement light and the radiation light that is disposed in front of the incident end face of the light receiving optical fiber 120 and is emitted from the measurement target portion when the measurement target portion is irradiated with the measurement light
  • an optical filter 142 that transmits a wavelength component other than the measurement light
  • a flat plate-shaped light shielding member 143 that is disposed between the optical filter 141 and the optical filter 142 and has a light shielding property with respect to the measurement light and the emitted light.
  • the outer peripheral portions of the optical filters 141 and 142 are covered only by a very small part (flat portions 141a and 142a) in contact with the light shielding member 143, and almost all the circumferences. It is kept exposed to the outside. Therefore, when the measurement light that diverges in the centrifugal direction of the irradiation optical fiber 110 passes through the optical filter 141, the measurement light reflected by the light shielding member 143 is minimized, and most of the measurement light is directed toward the measurement target region. Will go straight ahead. Therefore, a sufficient amount of measurement light is irradiated to the measurement target part, and the irradiation efficiency of the measurement light can be improved.
  • the optical filter 142 when the measurement target light included in the radiated light emitted from the measurement target region passes through the optical filter 142, the measurement target light reflected by the light shielding member 143 is minimized, and most of the measurement target light is The light travels straight toward the incident end face of the light receiving optical fiber 120. Accordingly, a sufficient amount of measurement target light is incident on the incident end face of the light receiving optical fiber 120, and the light receiving efficiency of the measurement target light can be improved.
  • the optical filters 141 and 142 are arranged in a part of a circle.
  • An optical filter can be easily produced as compared with a donut shape as described in the above-mentioned prior art document if it is a relatively simple shape that can be cut in such a straight line.
  • the tip surface of the light shielding member 143 and the tip surfaces of the optical filters 141 and 142 are arranged so as to be aligned in the probe longitudinal direction. It is not limited to.
  • the front end surface of the light shielding member 143 may be disposed so as to protrude from the front end surfaces of the optical filters 141 and 142. With this configuration, it is possible to prevent part of the measurement light that has passed through the optical filter 141 from being diffracted and incident on the optical filter 142 and conducted through the light receiving optical fiber 120.
  • the distal end surface of the light shielding member 143 is not excessively projected from the distal end surfaces of the optical filters 141 and 142, for example, 0 at the maximum. It is preferable to make it project by 1 [mm].
  • FIG. 5A is a front view of the fixed frame member 160 (a view of the fixed frame member 160 viewed from behind).
  • the fixed frame member 160 includes a cylindrical outer wall portion 160b that covers the circular portions 141b and 142b of the optical filters 141 and 142, flange portions 160a and 160c that face the distal end surface of the ferrule 130 and have openings 160d and 160e, respectively.
  • Have The light shielding member 143 is erected near the center in the fixed frame member 160.
  • the light shielding member 143 and the fixed frame member 160 may be formed integrally or separately.
  • the flange portions 160 a and 160 c of the fixed frame member 160 have an area larger than the optical path of the optical filters 141 and 142.
  • a transmissive member that transmits light over all wavelengths may be disposed between the flange portion 160a and the optical filter 141 and between the flange portion 160c and the optical filter 142.
  • the optical filters 141 and 142 are fixed to the fixed frame member 160.
  • the fixing frame member may be caulked and fixed by caulking portions 163 and 164 provided on the fixing frame member.
  • the optical filters 141 and 142 are fitted into the inner peripheral portion of the fixed frame member 160, and the convex portions 165 a, 165 b, By engaging 166a, 166b with concave portions 141c, 141d, 142c, 142d formed in the circular portions 141b, 142b of the optical filters 141, 142, respectively, the circular portions 141b, 142b of the optical filters 141, 142 are engaged. May be fixed to the fixed frame member 160.
  • the concave portions formed on the inner peripheral portion of the fixed frame member 160 and the convex portions formed on the circular shaped portions 141b and 142b of the optical filters 141 and 142 are engaged with each other, whereby the circles of the optical filters 141 and 142 are obtained.
  • the shape parts 141b and 142b may be fixed to the fixed frame member 160. From the viewpoint of improving the productivity of the optical filters 141 and 142 and the fixed frame member 160, the configuration shown in FIG. This is because no additional processing (concave portions 141c, 141d, 142c, 142d) is required for the optical filters 141, 142, and the manufacturing becomes easy.
  • the rear end portion of the light shielding member 143 is located at a position that does not overlap the exit end surface of the irradiation optical fiber 110 and the incident end surface of the light receiving optical fiber 120 on the front end surface of the ferrule 130.
  • An attachment groove 148 that can be attached to the ferrule 130 by inserting 143a may be formed.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Optics & Photonics (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Endoscopes (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

Une sonde (10) comprend : un filtre (141) optique qui est disposé devant une face d'extrémité d'émission de lumière d'une fibre optique pour irradiation (110) et émet des composantes de longueur d'onde d'une lumière de mesure pour irradiation d'un site à mesurer dans une lumière hors d'une lumière délivrée en sortie par la fibre optique pour irradiation (110) ; un filtre (142) optique qui est disposé devant une face d'extrémité d'entrée de lumière d'une fibre optique pour réception d'une lumière (120) et émet des composantes de longueur d'onde autres que la longueur d'onde de la lumière de mesure hors d'une lumière rayonnée, rayonnée depuis le site à mesurer en raison du site à mesurer qui est irradié avec la lumière de mesure ; et un élément (143) de blocage de lumière plat qui est disposé entre le filtre (141) optique et le filtre (142) optique et a des propriétés de blocage de lumière vis-à-vis de la lumière de mesure et de la lumière rayonnée.
PCT/JP2013/006634 2013-01-21 2013-11-11 Sonde, dispositif de spectrométrie et système de diagnostic WO2014111990A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2014557186A JP6237648B2 (ja) 2013-01-21 2013-11-11 プローブ、分光測定装置、および、診断システム

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JP2013-008397 2013-01-21
JP2013008397 2013-01-21

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WO2014111990A1 true WO2014111990A1 (fr) 2014-07-24

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180073060A (ko) * 2016-12-22 2018-07-02 테라셈 주식회사 프로브 유닛, 이것을 포함하는 광학 영상 장치, 및 광학 영상 장치의 제어 방법
KR20180073059A (ko) * 2016-12-22 2018-07-02 테라셈 주식회사 내시경 장치 및 이것의 제어 방법
EP3546929A1 (fr) * 2018-03-30 2019-10-02 Shimadzu Corporation Sonde de mesure optique et son procédé de production
EP3960063A1 (fr) * 2020-09-01 2022-03-02 Karl Storz SE & Co. KG Instrument optique et procédé de fabrication d'un instrument optique

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS597424U (ja) * 1982-07-05 1984-01-18 オリンパス光学工業株式会社 内視鏡
JP2004089236A (ja) * 2002-08-29 2004-03-25 Matsushita Electric Ind Co Ltd 歯観察装置
JP2004294109A (ja) * 2003-03-25 2004-10-21 Institute Of Physical & Chemical Research ラマンプローブ及びそれを用いたラマン散乱計測装置
JP2006212244A (ja) * 2005-02-04 2006-08-17 Matsushita Electric Ind Co Ltd う蝕歯検出装置
JP2009513249A (ja) * 2005-10-31 2009-04-02 ケアストリーム ヘルス インク う蝕検知の方法およびシステム

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS597424U (ja) * 1982-07-05 1984-01-18 オリンパス光学工業株式会社 内視鏡
JP2004089236A (ja) * 2002-08-29 2004-03-25 Matsushita Electric Ind Co Ltd 歯観察装置
JP2004294109A (ja) * 2003-03-25 2004-10-21 Institute Of Physical & Chemical Research ラマンプローブ及びそれを用いたラマン散乱計測装置
JP2006212244A (ja) * 2005-02-04 2006-08-17 Matsushita Electric Ind Co Ltd う蝕歯検出装置
JP2009513249A (ja) * 2005-10-31 2009-04-02 ケアストリーム ヘルス インク う蝕検知の方法およびシステム

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180073060A (ko) * 2016-12-22 2018-07-02 테라셈 주식회사 프로브 유닛, 이것을 포함하는 광학 영상 장치, 및 광학 영상 장치의 제어 방법
KR20180073059A (ko) * 2016-12-22 2018-07-02 테라셈 주식회사 내시경 장치 및 이것의 제어 방법
KR101940046B1 (ko) 2016-12-22 2019-01-18 주식회사 모멘텀컨설팅 내시경 장치 및 이것의 제어 방법
KR101944760B1 (ko) 2016-12-22 2019-04-17 주식회사 모멘텀컨설팅 프로브 유닛, 이것을 포함하는 광학 영상 장치, 및 광학 영상 장치의 제어 방법
EP3546929A1 (fr) * 2018-03-30 2019-10-02 Shimadzu Corporation Sonde de mesure optique et son procédé de production
EP3960063A1 (fr) * 2020-09-01 2022-03-02 Karl Storz SE & Co. KG Instrument optique et procédé de fabrication d'un instrument optique

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JP6237648B2 (ja) 2017-11-29

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